DCAMKL1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0MZ66 S473 Sugiyama SHTN1 KIAA1598 LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
O15075 S151 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 CGSIEPFKKLEYTKNVNPNWsVNVKTTSAsRAVssLATAKG
O15075 S160 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 LEYTKNVNPNWsVNVKTTSAsRAVssLATAKGsPsEVRENK
O15075 S164 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 KNVNPNWsVNVKTTSAsRAVssLATAKGsPsEVRENKDFIR
O15075 S165 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 NVNPNWsVNVKTTSAsRAVssLATAKGsPsEVRENKDFIRP
O15075 S172 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 VNVKTTSAsRAVssLATAKGsPsEVRENKDFIRPKLVTIIR
O15075 S174 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 VKTTSAsRAVssLATAKGsPsEVRENKDFIRPKLVTIIRSG
O15075 S274 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 IFIACGPEKFRYQDDFLLDEsECRVVKSTSYTKIASSSRRS
O15075 S438 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 LKIIKKSKCRGKEHMIQNEVsILRRVKHPNIVLLIEEMDVP
O15075 S51 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 PsPtHsAHCSFYRTRtLQtLsSEKKAKKVRFYRNGDRYFKG
O15075 S96 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 ISPDRFRSFEALLADLTRTLsDNVNLPQGVRTIYTIDGLKK
O15075 T395 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 VSEEGFQIPATITERYKVGRtIGDGNFAVVKECVERSTARE
O15075 T46 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 RVNGLPsPtHsAHCSFYRTRtLQtLsSEKKAKKVRFYRNGD
O15075 T49 Sugiyama DCLK1 DCAMKL1 DCDC3A KIAA0369 GLPsPtHsAHCSFYRTRtLQtLsSEKKAKKVRFYRNGDRYF
O15078 S1159 Sugiyama CEP290 BBS14 KIAA0373 NPHP6 LELEKNEMELKVEVSKLREIsDIARRQVEILNAQQQSRDKE
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43615 S193 Sugiyama TIMM44 MIMT44 TIM44 TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O43707 T69 Sugiyama ACTN4 EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O60343 S486 Sugiyama TBC1D4 AS160 KIAA0603 ERIEGLYPPRAKLVIQRHLssLtDNEQADIFERVQKMKPVS
O60664 T216 Sugiyama PLIN3 M6PRBP1 TIP47 sEEWADNHLPLTDAELARIAtsLDGFDVAsVQQQRQEQSyF
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75391 S57 Sugiyama SPAG7 LQEQEKQQKVEFRKRMEKEVsDFIQDsGQIKKKFQPMNKIE
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O96019 S233 Sugiyama ACTL6A BAF53 BAF53A INO80K MNIELVPPYMIASKEAVREGsPANWKRKEKLPQVTRSWHNY
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00441 S108 Sugiyama SOD1 VtADKDGVADVsIEDsVIsLsGDHCIIGRTLVVHEKADDLG
P00441 S99 Sugiyama SOD1 ERHVGDLGNVtADKDGVADVsIEDsVIsLsGDHCIIGRTLV
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04040 S515 Sugiyama CAT ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040 T511 Sugiyama CAT SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075 S17 Sugiyama ALDOA ALDA ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07384 S474 Sugiyama CAPN1 CANPL1 PIG30 GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07737 S85 Sugiyama PFN1 tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T467 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKEN
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972 S17 Sugiyama ALDOC ALDC ____MPHSYPALSAEQKKELsDIALRIVAPGKGILAADEsV
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 Y579 Sugiyama EEF2 EF2 KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20290 S126 Sugiyama BTF3 NACB OK/SW-cl.8 VNMFTNQGTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEM
P20290 T131 Sugiyama BTF3 NACB OK/SW-cl.8 NQGTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsIL
P20290 T140 Sugiyama BTF3 NACB OK/SW-cl.8 NPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQLGADsLt
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P22059 S240 Sugiyama OSBP OSBP1 DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P35579 S1915 Sugiyama MYH9 KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P40926 T179 Sugiyama MDH2 GVYNPNKIFGVTTLDIVRANtFVAELKGLDPARVNVPVIGG
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46940 S343 Sugiyama IQGAP1 KIAA0051 ALFRALQsPALGLRGLQQQNsDWYLKQLLSDKQQKRQsGQT
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P50454 S138 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 LSNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEH
P50454 S141 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52789 S889 Sugiyama HK2 PHFAKVMHETVKDLAPKCDVsFLQsEDGSGKGAALITAVAC
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 T304 Sugiyama ACTB KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60842 S394 Sugiyama EIF4A1 DDX2A EIF4A NMVTEEDKRTLRDIEtFyNtsIEEMPLNVADLI________
P60842 T393 Sugiyama EIF4A1 DDX2A EIF4A INMVTEEDKRTLRDIEtFyNtsIEEMPLNVADLI_______
P60842 Y391 Sugiyama EIF4A1 DDX2A EIF4A VAINMVTEEDKRTLRDIEtFyNtsIEEMPLNVADLI_____
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61081 T176 Sugiyama UBE2M UBC12 NRRLFEQNVQRSMRGGyIGstyFERCLK_____________
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62316 T40 Sugiyama SNRPD2 SNRPD1 EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62753 T34 Sugiyama RPS6 OK/SW-cl.2 KLIEVDDERKLRtFyEKRMAtEVAADALGEEWKGYVVRIsG
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 T304 Sugiyama ACTG1 ACTG KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02790 T42 Sugiyama FKBP4 FKBP52 GVDIsPKQDEGVLKVIKREGtGTEMPMIGDRVFVHYTGWLL
Q04917 T31 Sugiyama YWHAH YWHA1 ARLAEQAERyDDMAsAMKAVtELNEPLsNEDRNLLsVAyKN
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06210 T262 Sugiyama GFPT1 GFAT GFPT sQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDAS
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14677 S210 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 KNKSAFPFSDKLGELsDKIGstIDDtIsKFRRKDREDsPER
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15121 S116 Sugiyama PEA15 DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q16531 T1125 Sugiyama DDB1 XAP1 MQEVVANLQYDDGSGMKREAtADDLIKVVEELtRIH_____
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q2TAA2 S241 Sugiyama IAH1 SSLPLLLPYWRDVAEAKPELsLLGDGDH_____________
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5SSJ5 S227 Sugiyama HP1BP3 LKRELNRGVIKQVKGKGAsGsFVVVQKSRKTPQKSRNRKNR
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX12 S343 PSP CCAR1 CARP1 DIS ERERRRSRERSPQRKRSRERsPRRERERSPRRVRRVVPRYT
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8WVC0 T477 Sugiyama LEO1 RDL FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q99426 T120 Sugiyama TBCB CG22 CKAP1 DVSRVEKytIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQ
Q99613 S754 Sugiyama EIF3C EIF3S8 REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NZL9 S9 Sugiyama MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 ____________MVGREKELsIHFVPGsCRLVEEEVNIPNR
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5B9 S650 Sugiyama SUPT16H FACT140 FACTP140 KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 1.609192e-10 9.793 0 0
Nervous system development R-HSA-9675108 2.507339e-09 8.601 0 0
Cell Cycle R-HSA-1640170 2.446294e-08 7.611 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.291544e-08 7.640 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.602076e-08 7.585 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.213406e-08 7.207 0 0
Signal Transduction R-HSA-162582 2.255373e-07 6.647 0 0
Cell Cycle, Mitotic R-HSA-69278 4.359127e-07 6.361 0 0
Apoptotic execution phase R-HSA-75153 4.248462e-07 6.372 0 0
NRAGE signals death through JNK R-HSA-193648 1.289517e-06 5.890 0 0
Gene expression (Transcription) R-HSA-74160 2.503118e-06 5.602 0 0
RNA Polymerase II Transcription R-HSA-73857 4.819550e-06 5.317 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.765150e-06 5.239 0 0
Chromatin modifying enzymes R-HSA-3247509 6.029098e-06 5.220 0 0
Chromatin organization R-HSA-4839726 7.429329e-06 5.129 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.865291e-06 5.052 0 0
G alpha (12/13) signalling events R-HSA-416482 2.349738e-05 4.629 0 0
Signaling by ROBO receptors R-HSA-376176 3.091501e-05 4.510 0 0
mRNA 3'-end processing R-HSA-72187 6.188640e-05 4.208 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.735548e-05 4.172 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.417276e-05 4.075 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.884378e-05 4.005 0 0
Regulation of TP53 Activity R-HSA-5633007 1.054528e-04 3.977 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.200341e-04 3.921 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.227112e-04 3.911 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.224316e-04 3.912 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.224316e-04 3.912 0 0
M Phase R-HSA-68886 1.179978e-04 3.928 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.362214e-04 3.866 0 0
Cellular Senescence R-HSA-2559583 1.585684e-04 3.800 0 0
Generic Transcription Pathway R-HSA-212436 1.806603e-04 3.743 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.133428e-04 3.671 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.171085e-04 3.663 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.216608e-04 3.654 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.346631e-04 3.630 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.501956e-04 3.602 0 0
Striated Muscle Contraction R-HSA-390522 2.542825e-04 3.595 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.768318e-04 3.558 0 0
Cell Cycle Checkpoints R-HSA-69620 2.763787e-04 3.558 0 0
Death Receptor Signaling R-HSA-73887 2.782164e-04 3.556 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.028708e-04 3.519 0 0
Semaphorin interactions R-HSA-373755 3.263599e-04 3.486 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.430753e-04 3.465 0 0
Post NMDA receptor activation events R-HSA-438064 3.710996e-04 3.431 0 0
HDMs demethylate histones R-HSA-3214842 3.848963e-04 3.415 0 0
Signaling by VEGF R-HSA-194138 4.441999e-04 3.352 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.819405e-04 3.317 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.278008e-04 3.278 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.532246e-04 3.257 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.532246e-04 3.257 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.532246e-04 3.257 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.240736e-04 3.281 0 0
EPH-Ephrin signaling R-HSA-2682334 5.036052e-04 3.298 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.333286e-04 3.273 0 0
Signaling by RAS mutants R-HSA-6802949 5.532246e-04 3.257 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.539676e-04 3.257 0 0
Ephrin signaling R-HSA-3928664 7.503084e-04 3.125 0 0
Apoptosis R-HSA-109581 7.414443e-04 3.130 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.906646e-04 3.102 0 0
MAPK family signaling cascades R-HSA-5683057 7.802150e-04 3.108 0 0
Co-stimulation by CD28 R-HSA-389356 8.671319e-04 3.062 0 0
CREB phosphorylation R-HSA-199920 1.035151e-03 2.985 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.019543e-03 2.992 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.059883e-03 2.975 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.083991e-03 2.965 0 0
Rap1 signalling R-HSA-392517 1.073884e-03 2.969 0 0
Programmed Cell Death R-HSA-5357801 1.032244e-03 2.986 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.125403e-03 2.949 0 0
Mitotic Anaphase R-HSA-68882 1.197308e-03 2.922 0 0
L1CAM interactions R-HSA-373760 1.264575e-03 2.898 0 0
Activation of RAC1 R-HSA-428540 1.300367e-03 2.886 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.317914e-03 2.880 0 0
Integrin signaling R-HSA-354192 1.400230e-03 2.854 0 0
Calmodulin induced events R-HSA-111933 1.490574e-03 2.827 0 0
CaM pathway R-HSA-111997 1.490574e-03 2.827 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.505632e-03 2.822 0 0
Cell-Cell communication R-HSA-1500931 1.525609e-03 2.817 0 0
Mitotic Prometaphase R-HSA-68877 1.864451e-03 2.729 0 0
FLT3 Signaling R-HSA-9607240 1.944032e-03 2.711 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.021498e-03 2.694 0 0
Trafficking of AMPA receptors R-HSA-399719 2.167109e-03 2.664 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.313383e-03 2.636 0 0
G2/M Transition R-HSA-69275 2.383820e-03 2.623 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.384317e-03 2.623 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.799898e-03 2.553 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.120922e-03 2.506 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.947705e-03 2.531 0 0
FOXO-mediated transcription R-HSA-9614085 3.105875e-03 2.508 0 0
Long-term potentiation R-HSA-9620244 3.120922e-03 2.506 0 0
Muscle contraction R-HSA-397014 3.138791e-03 2.503 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.158707e-03 2.500 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.284032e-03 2.484 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.510959e-03 2.455 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.602542e-03 2.443 0 0
RET signaling R-HSA-8853659 3.602542e-03 2.443 0 0
Recycling pathway of L1 R-HSA-437239 3.593793e-03 2.444 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.510959e-03 2.455 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.788277e-03 2.422 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.975710e-03 2.401 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.985371e-03 2.400 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.096205e-03 2.388 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.415482e-03 2.355 0 0
Netrin-1 signaling R-HSA-373752 4.415482e-03 2.355 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.563002e-03 2.341 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.878827e-03 2.312 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.892533e-03 2.310 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.996952e-03 2.301 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.029806e-03 2.298 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.192222e-03 2.285 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.329565e-03 2.273 0 0
Signaling by Hippo R-HSA-2028269 5.198185e-03 2.284 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.192222e-03 2.285 0 0
DAG and IP3 signaling R-HSA-1489509 5.329565e-03 2.273 0 0
Cell junction organization R-HSA-446728 5.420777e-03 2.266 0 0
RAF activation R-HSA-5673000 5.472043e-03 2.262 0 0
Signaling by NTRKs R-HSA-166520 5.547233e-03 2.256 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.808956e-03 2.236 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.042896e-03 2.219 0 0
Neurodegenerative Diseases R-HSA-8863678 6.302902e-03 2.200 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.302902e-03 2.200 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.302902e-03 2.200 0 0
Separation of Sister Chromatids R-HSA-2467813 6.482858e-03 2.188 0 0
Metabolism of RNA R-HSA-8953854 6.513622e-03 2.186 0 0
Ca-dependent events R-HSA-111996 6.562020e-03 2.183 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.741053e-03 2.171 0 0
Rab regulation of trafficking R-HSA-9007101 7.396673e-03 2.131 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.631526e-03 2.117 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.631526e-03 2.117 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.636023e-03 2.117 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.636023e-03 2.117 0 0
Kinesins R-HSA-983189 7.839047e-03 2.106 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.277847e-03 2.082 0 0
mRNA Splicing R-HSA-72172 8.343213e-03 2.079 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.235274e-03 2.035 0 0
Signaling by ALK in cancer R-HSA-9700206 9.235274e-03 2.035 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.982506e-03 2.001 0 0
TRP channels R-HSA-3295583 1.012324e-02 1.995 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.390130e-03 2.027 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.111318e-02 1.954 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.196706e-02 1.922 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.225760e-02 1.912 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.260610e-02 1.899 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.273554e-02 1.895 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.273554e-02 1.895 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.335068e-02 1.874 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.395977e-02 1.855 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.413329e-02 1.850 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.562173e-02 1.806 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.562173e-02 1.806 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.456477e-02 1.837 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.527231e-02 1.816 0 0
Signaling by ERBB2 R-HSA-1227986 1.492673e-02 1.826 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.533049e-02 1.814 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.564952e-02 1.805 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.564952e-02 1.805 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.601262e-02 1.796 0 0
TBC/RABGAPs R-HSA-8854214 1.621643e-02 1.790 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.676254e-02 1.776 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.691024e-02 1.772 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.025091e-02 1.694 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.025091e-02 1.694 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.025091e-02 1.694 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.025091e-02 1.694 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.003048e-02 1.698 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.129602e-02 1.672 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.129602e-02 1.672 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.129602e-02 1.672 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.129602e-02 1.672 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.129602e-02 1.672 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.129602e-02 1.672 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.129602e-02 1.672 0 0
DCC mediated attractive signaling R-HSA-418885 1.766501e-02 1.753 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.766501e-02 1.753 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.766501e-02 1.753 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.794710e-02 1.746 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.953322e-02 1.709 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.097761e-02 1.678 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.825436e-02 1.739 0 0
Centrosome maturation R-HSA-380287 1.792557e-02 1.747 0 0
ESR-mediated signaling R-HSA-8939211 2.122893e-02 1.673 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.878128e-02 1.726 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.894010e-02 1.723 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.020961e-02 1.694 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.842033e-02 1.735 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.107340e-02 1.676 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.805114e-02 1.743 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.842033e-02 1.735 0 0
Signaling by Interleukins R-HSA-449147 1.977402e-02 1.704 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.213350e-02 1.655 0 0
MAP2K and MAPK activation R-HSA-5674135 2.347967e-02 1.629 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.381895e-02 1.623 0 0
The NLRP3 inflammasome R-HSA-844456 2.381895e-02 1.623 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.433026e-02 1.614 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.539233e-02 1.595 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.539233e-02 1.595 0 0
Mitotic Prophase R-HSA-68875 2.550327e-02 1.593 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.752456e-02 1.560 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.826146e-02 1.549 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.826146e-02 1.549 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.177776e-02 1.498 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.177776e-02 1.498 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.177776e-02 1.498 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.177776e-02 1.498 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.177776e-02 1.498 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.975116e-02 1.526 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.975116e-02 1.526 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.074320e-02 1.512 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.974800e-02 1.527 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.238732e-02 1.490 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.238732e-02 1.490 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.222453e-02 1.492 0 0
G0 and Early G1 R-HSA-1538133 3.252019e-02 1.488 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.259979e-02 1.487 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.259979e-02 1.487 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.292976e-02 1.482 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.292976e-02 1.482 0 0
NrCAM interactions R-HSA-447038 3.292976e-02 1.482 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.324684e-02 1.478 0 0
Signaling by APC mutants R-HSA-4839744 3.449080e-02 1.462 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.449080e-02 1.462 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.449080e-02 1.462 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.449080e-02 1.462 0 0
PECAM1 interactions R-HSA-210990 3.449080e-02 1.462 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.600358e-02 1.444 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.662558e-02 1.436 0 0
Regulation of KIT signaling R-HSA-1433559 3.662558e-02 1.436 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.665634e-02 1.436 0 0
Specification of primordial germ cells R-HSA-9827857 3.712754e-02 1.430 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.170805e-02 1.380 0 0
Type I hemidesmosome assembly R-HSA-446107 4.170805e-02 1.380 0 0
RSK activation R-HSA-444257 4.170805e-02 1.380 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.267660e-02 1.370 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.267660e-02 1.370 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.906918e-02 1.408 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.906382e-02 1.408 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.906382e-02 1.408 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.143848e-02 1.383 0 0
Cellular response to heat stress R-HSA-3371556 4.217095e-02 1.375 0 0
DARPP-32 events R-HSA-180024 4.054343e-02 1.392 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.170805e-02 1.380 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.766876e-02 1.424 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.766876e-02 1.424 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.766876e-02 1.424 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.387687e-02 1.358 0 0
Cellular responses to stress R-HSA-2262752 4.017723e-02 1.396 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.170805e-02 1.380 0 0
Cellular responses to stimuli R-HSA-8953897 3.914659e-02 1.407 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.054343e-02 1.392 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.036248e-02 1.394 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.455603e-02 1.351 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.476408e-02 1.349 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.490101e-02 1.348 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.546215e-02 1.342 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.546215e-02 1.342 0 0
Signaling by AXIN mutants R-HSA-4839735 4.546215e-02 1.342 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.595044e-02 1.338 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.595044e-02 1.338 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.595044e-02 1.338 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.595044e-02 1.338 0 0
Polo-like kinase mediated events R-HSA-156711 4.595044e-02 1.338 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.595044e-02 1.338 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 4.626264e-02 1.335 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.626264e-02 1.335 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.626264e-02 1.335 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.626264e-02 1.335 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.626264e-02 1.335 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.626264e-02 1.335 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.745132e-02 1.324 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.756410e-02 1.323 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.773235e-02 1.321 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.859521e-02 1.313 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.935335e-02 1.307 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.935335e-02 1.307 0 0
HSF1-dependent transactivation R-HSA-3371571 4.966078e-02 1.304 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.253101e-02 1.280 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.636978e-02 1.249 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.636978e-02 1.249 0 0
ALK mutants bind TKIs R-HSA-9700645 5.636978e-02 1.249 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.838097e-02 1.234 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.787007e-02 1.238 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.966007e-02 1.224 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.324478e-02 1.199 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.339832e-02 1.272 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.353404e-02 1.271 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.636978e-02 1.249 0 0
Neurexins and neuroligins R-HSA-6794361 5.590537e-02 1.253 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.339832e-02 1.272 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.141478e-02 1.212 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.297446e-02 1.201 0 0
Membrane Trafficking R-HSA-199991 5.718633e-02 1.243 0 0
Signaling by LTK R-HSA-9842663 5.838097e-02 1.234 0 0
Regulation of CDH1 Function R-HSA-9764561 5.762938e-02 1.239 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.110380e-02 1.214 0 0
Developmental Biology R-HSA-1266738 6.046032e-02 1.219 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.341740e-02 1.272 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.966007e-02 1.224 0 0
PLC beta mediated events R-HSA-112043 5.302522e-02 1.276 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.904323e-02 1.229 0 0
Interleukin-12 signaling R-HSA-9020591 5.617352e-02 1.250 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.459540e-02 1.190 0 0
Signaling by WNT in cancer R-HSA-4791275 6.459540e-02 1.190 0 0
Formation of definitive endoderm R-HSA-9823730 6.744277e-02 1.171 0 0
Nephrin family interactions R-HSA-373753 6.744277e-02 1.171 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.804715e-02 1.167 0 0
Nef and signal transduction R-HSA-164944 6.951861e-02 1.158 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.084895e-02 1.150 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.187043e-02 1.143 0 0
Homology Directed Repair R-HSA-5693538 7.242802e-02 1.140 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.327957e-02 1.135 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.327957e-02 1.135 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.327957e-02 1.135 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.327957e-02 1.135 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.327957e-02 1.135 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.412384e-02 1.130 0 0
G-protein beta:gamma signalling R-HSA-397795 7.431615e-02 1.129 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.431615e-02 1.129 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.431615e-02 1.129 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.431615e-02 1.129 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.456695e-02 1.127 0 0
Peptide chain elongation R-HSA-156902 7.456695e-02 1.127 0 0
Diseases of programmed cell death R-HSA-9645723 7.456695e-02 1.127 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 8.408664e-02 1.075 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 8.408664e-02 1.075 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 8.408664e-02 1.075 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.326748e-02 1.030 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.326748e-02 1.030 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.542142e-02 1.068 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.542142e-02 1.068 0 0
Deadenylation of mRNA R-HSA-429947 7.482267e-02 1.126 0 0
TGFBR3 expression R-HSA-9839394 8.716967e-02 1.060 0 0
Regulation of endogenous retroelements R-HSA-9842860 8.006540e-02 1.097 0 0
Signaling by EGFR R-HSA-177929 8.622484e-02 1.064 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.706970e-02 1.113 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.802063e-02 1.108 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.622484e-02 1.064 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.016941e-02 1.096 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.777884e-02 1.109 0 0
S Phase R-HSA-69242 8.831678e-02 1.054 0 0
Activation of BH3-only proteins R-HSA-114452 9.244032e-02 1.034 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.111366e-02 1.091 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.831678e-02 1.054 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.777884e-02 1.109 0 0
Ion homeostasis R-HSA-5578775 8.622484e-02 1.064 0 0
Dopamine receptors R-HSA-390651 8.408664e-02 1.075 0 0
PTEN Regulation R-HSA-6807070 9.072274e-02 1.042 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.843024e-02 1.106 0 0
MAP kinase activation R-HSA-450294 8.715336e-02 1.060 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.117237e-02 1.040 0 0
MTOR signalling R-HSA-165159 9.086787e-02 1.042 0 0
Signaling by WNT R-HSA-195721 7.935880e-02 1.100 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.289556e-02 1.032 0 0
Cell-cell junction organization R-HSA-421270 8.423372e-02 1.075 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.111366e-02 1.091 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.048871e-02 1.094 0 0
MECP2 regulates transcription factors R-HSA-9022707 9.326748e-02 1.030 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.048871e-02 1.094 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.198479e-02 1.086 0 0
Manipulation of host energy metabolism R-HSA-9636667 9.332272e-02 1.030 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 9.332272e-02 1.030 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 9.332272e-02 1.030 0 0
Breakdown of the nuclear lamina R-HSA-352238 9.332272e-02 1.030 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 9.345034e-02 1.029 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 9.345034e-02 1.029 0 0
HATs acetylate histones R-HSA-3214847 9.367220e-02 1.028 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.420505e-02 1.026 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.543722e-02 1.020 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.543722e-02 1.020 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.582348e-02 1.019 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.592199e-02 1.018 0 0
G-protein mediated events R-HSA-112040 9.616994e-02 1.017 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.640027e-02 1.016 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 9.935064e-02 1.003 0 0
Glycolysis R-HSA-70171 1.007742e-01 0.997 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.012732e-01 0.995 0 0
Deubiquitination R-HSA-5688426 1.014643e-01 0.994 0 0
PKA activation in glucagon signalling R-HSA-164378 1.015721e-01 0.993 0 0
PKA activation R-HSA-163615 1.015721e-01 0.993 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.040842e-01 0.983 0 0
Smooth Muscle Contraction R-HSA-445355 1.040842e-01 0.983 0 0
Adherens junctions interactions R-HSA-418990 1.045089e-01 0.981 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.050186e-01 0.979 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.050512e-01 0.979 0 0
Signalling to ERKs R-HSA-187687 1.087673e-01 0.964 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.089390e-01 0.963 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.089390e-01 0.963 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.095951e-01 0.960 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.097236e-01 0.960 0 0
IGF1R signaling cascade R-HSA-2428924 1.147390e-01 0.940 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.152651e-01 0.938 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.184532e-01 0.926 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.184532e-01 0.926 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.184532e-01 0.926 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.564177e-01 0.806 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.564177e-01 0.806 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.564177e-01 0.806 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.564177e-01 0.806 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.564177e-01 0.806 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.489973e-01 0.827 0 0
Regulation of TP53 Expression R-HSA-6804754 1.489973e-01 0.827 0 0
C6 deamination of adenosine R-HSA-75102 1.489973e-01 0.827 0 0
Potassium transport channels R-HSA-1296067 1.489973e-01 0.827 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.570587e-01 0.804 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.570587e-01 0.804 0 0
Lipophagy R-HSA-9613354 1.503042e-01 0.823 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.402096e-01 0.853 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.402096e-01 0.853 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.295659e-01 0.888 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.192607e-01 0.924 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.192607e-01 0.924 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.384244e-01 0.859 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.384244e-01 0.859 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.384244e-01 0.859 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.384244e-01 0.859 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.262467e-01 0.899 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.589794e-01 0.799 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.589794e-01 0.799 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.589794e-01 0.799 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.589794e-01 0.799 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.441321e-01 0.841 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.441321e-01 0.841 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.309744e-01 0.883 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.192537e-01 0.924 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.372417e-01 0.863 0 0
HDACs deacetylate histones R-HSA-3214815 1.256619e-01 0.901 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.249826e-01 0.903 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.366649e-01 0.864 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.346375e-01 0.871 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.383545e-01 0.859 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.364470e-01 0.865 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.458446e-01 0.836 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.306117e-01 0.884 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.306117e-01 0.884 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.510341e-01 0.821 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.499081e-01 0.824 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.341145e-01 0.873 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.242876e-01 0.906 0 0
ERK/MAPK targets R-HSA-198753 1.589794e-01 0.799 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.454678e-01 0.837 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.503042e-01 0.823 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.519129e-01 0.818 0 0
Eukaryotic Translation Termination R-HSA-72764 1.458446e-01 0.836 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.377346e-01 0.861 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.192607e-01 0.924 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.295659e-01 0.888 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.325672e-01 0.878 0 0
Cardiogenesis R-HSA-9733709 1.341145e-01 0.873 0 0
Opioid Signalling R-HSA-111885 1.325672e-01 0.878 0 0
HIV Life Cycle R-HSA-162587 1.457518e-01 0.836 0 0
HIV Infection R-HSA-162906 1.564582e-01 0.806 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.238349e-01 0.907 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.570587e-01 0.804 0 0
Inflammasomes R-HSA-622312 1.309744e-01 0.883 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.341145e-01 0.873 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.203194e-01 0.920 0 0
Interleukin-1 processing R-HSA-448706 1.503042e-01 0.823 0 0
RAB geranylgeranylation R-HSA-8873719 1.254586e-01 0.901 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.589794e-01 0.799 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.192607e-01 0.924 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.343641e-01 0.872 0 0
Interleukin-12 family signaling R-HSA-447115 1.503089e-01 0.823 0 0
Formation of the nephric duct R-HSA-9830364 1.631885e-01 0.787 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.655298e-01 0.781 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.655298e-01 0.781 0 0
Interleukin-37 signaling R-HSA-9008059 1.655298e-01 0.781 0 0
Signaling by FGFR4 R-HSA-5654743 1.662886e-01 0.779 0 0
Signaling by SCF-KIT R-HSA-1433557 1.662886e-01 0.779 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.665965e-01 0.778 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.665965e-01 0.778 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.667640e-01 0.778 0 0
Maturation of nucleoprotein R-HSA-9683610 1.667640e-01 0.778 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.667659e-01 0.778 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.667659e-01 0.778 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.685347e-01 0.773 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.697114e-01 0.770 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.883764e-01 0.540 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.883764e-01 0.540 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.883764e-01 0.540 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.883764e-01 0.540 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.883764e-01 0.540 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.883764e-01 0.540 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.883764e-01 0.540 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.883764e-01 0.540 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.883764e-01 0.540 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.883764e-01 0.540 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.883764e-01 0.540 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.094420e-01 0.679 0 0
MET activates PTPN11 R-HSA-8865999 2.094420e-01 0.679 0 0
Regulation of gap junction activity R-HSA-191650 2.718038e-01 0.566 0 0
HCN channels R-HSA-1296061 2.718038e-01 0.566 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.718038e-01 0.566 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.718038e-01 0.566 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.718038e-01 0.566 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.718038e-01 0.566 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.996996e-01 0.398 0 0
Mitochondrial transcription initiation R-HSA-163282 3.996996e-01 0.398 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.996996e-01 0.398 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.996996e-01 0.398 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.996996e-01 0.398 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.996996e-01 0.398 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.996996e-01 0.398 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.996996e-01 0.398 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.996996e-01 0.398 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.996996e-01 0.398 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.996996e-01 0.398 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.996996e-01 0.398 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.996996e-01 0.398 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.996996e-01 0.398 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.996996e-01 0.398 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.996996e-01 0.398 0 0
Intestinal infectious diseases R-HSA-8942233 3.996996e-01 0.398 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.996996e-01 0.398 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.996996e-01 0.398 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.996996e-01 0.398 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.996996e-01 0.398 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.996996e-01 0.398 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.996996e-01 0.398 0 0
2-LTR circle formation R-HSA-164843 1.827920e-01 0.738 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.429965e-01 0.614 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.429965e-01 0.614 0 0
Disinhibition of SNARE formation R-HSA-114516 2.429965e-01 0.614 0 0
SOS-mediated signalling R-HSA-112412 2.429965e-01 0.614 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.429965e-01 0.614 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.429965e-01 0.614 0 0
Activation of AKT2 R-HSA-165158 3.340049e-01 0.476 0 0
IRS activation R-HSA-74713 3.340049e-01 0.476 0 0
G2 Phase R-HSA-68911 3.340049e-01 0.476 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.340049e-01 0.476 0 0
Defective F9 activation R-HSA-9673221 3.340049e-01 0.476 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.340049e-01 0.476 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.951128e-01 0.710 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.884500e-01 0.540 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.884500e-01 0.540 0 0
Regulation by c-FLIP R-HSA-3371378 2.884500e-01 0.540 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.884500e-01 0.540 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 2.884500e-01 0.540 0 0
Dimerization of procaspase-8 R-HSA-69416 2.884500e-01 0.540 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.884500e-01 0.540 0 0
MET receptor recycling R-HSA-8875656 2.884500e-01 0.540 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.884500e-01 0.540 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.534179e-01 0.596 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.534179e-01 0.596 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.249841e-01 0.648 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.249841e-01 0.648 0 0
GAB1 signalosome R-HSA-180292 2.011723e-01 0.696 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.011723e-01 0.696 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.906185e-01 0.537 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.906185e-01 0.537 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.906185e-01 0.537 0 0
ARMS-mediated activation R-HSA-170984 3.344535e-01 0.476 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.344535e-01 0.476 0 0
CASP8 activity is inhibited R-HSA-5218900 3.344535e-01 0.476 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.945702e-01 0.404 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.945702e-01 0.404 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.945702e-01 0.404 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.945702e-01 0.404 0 0
PKB-mediated events R-HSA-109703 3.945702e-01 0.404 0 0
PDE3B signalling R-HSA-165160 3.945702e-01 0.404 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.945702e-01 0.404 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.945702e-01 0.404 0 0
Phosphorylation of Emi1 R-HSA-176417 3.945702e-01 0.404 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.945702e-01 0.404 0 0
Signaling by MAPK mutants R-HSA-9652817 3.945702e-01 0.404 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.936133e-01 0.307 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.936133e-01 0.307 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.936133e-01 0.307 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.936133e-01 0.307 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.936133e-01 0.307 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.936133e-01 0.307 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.936133e-01 0.307 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.936133e-01 0.307 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.936133e-01 0.307 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.936133e-01 0.307 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.045005e-01 0.689 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.045005e-01 0.689 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.045005e-01 0.689 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.881517e-01 0.540 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.881517e-01 0.540 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.881517e-01 0.540 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.265725e-01 0.645 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.265725e-01 0.645 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.265725e-01 0.645 0 0
HIV elongation arrest and recovery R-HSA-167287 2.265725e-01 0.645 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.265725e-01 0.645 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.284793e-01 0.483 0 0
Formation of axial mesoderm R-HSA-9796292 3.284793e-01 0.483 0 0
HIV Transcription Elongation R-HSA-167169 1.832629e-01 0.737 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.832629e-01 0.737 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.832629e-01 0.737 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.832629e-01 0.737 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.528690e-01 0.597 0 0
PI3K/AKT activation R-HSA-198203 3.803115e-01 0.420 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.803115e-01 0.420 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.803115e-01 0.420 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.803115e-01 0.420 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.803115e-01 0.420 0 0
Signaling by Erythropoietin R-HSA-9006335 2.494521e-01 0.603 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.494521e-01 0.603 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.494521e-01 0.603 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.494521e-01 0.603 0 0
Late endosomal microautophagy R-HSA-9615710 2.494521e-01 0.603 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.494521e-01 0.603 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.494521e-01 0.603 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.208752e-01 0.494 0 0
Tight junction interactions R-HSA-420029 2.785974e-01 0.555 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.785974e-01 0.555 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.455098e-01 0.610 0 0
Metabolism of non-coding RNA R-HSA-194441 1.758664e-01 0.755 0 0
snRNP Assembly R-HSA-191859 1.758664e-01 0.755 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.149921e-01 0.668 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.730296e-01 0.564 0 0
DAP12 signaling R-HSA-2424491 2.730296e-01 0.564 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.730296e-01 0.564 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.665886e-01 0.436 0 0
Removal of the Flap Intermediate R-HSA-69166 3.665886e-01 0.436 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.524898e-01 0.344 0 0
STAT5 Activation R-HSA-9645135 4.524898e-01 0.344 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.524898e-01 0.344 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.524898e-01 0.344 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.673284e-01 0.573 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.673284e-01 0.573 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.049397e-01 0.516 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.049397e-01 0.516 0 0
EGFR downregulation R-HSA-182971 2.971915e-01 0.527 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.971915e-01 0.527 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.971915e-01 0.527 0 0
Notch-HLH transcription pathway R-HSA-350054 3.424257e-01 0.465 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.254403e-01 0.371 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.254403e-01 0.371 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.254403e-01 0.371 0 0
Meiotic synapsis R-HSA-1221632 2.450019e-01 0.611 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.824924e-01 0.549 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.045731e-01 0.393 0 0
G1/S-Specific Transcription R-HSA-69205 3.125413e-01 0.505 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.872337e-01 0.412 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.872337e-01 0.412 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.872337e-01 0.412 0 0
PI3K Cascade R-HSA-109704 2.877890e-01 0.541 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.877890e-01 0.541 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.722186e-01 0.429 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.733166e-01 0.563 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.468059e-01 0.460 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.357496e-01 0.474 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.255236e-01 0.487 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.906870e-01 0.537 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.704974e-01 0.568 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.203682e-01 0.376 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.203682e-01 0.376 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.421020e-01 0.354 0 0
Differentiation of T cells R-HSA-9945266 4.421020e-01 0.354 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.421020e-01 0.354 0 0
Regulation of BACH1 activity R-HSA-9708530 4.421020e-01 0.354 0 0
Phosphorylation of the APC/C R-HSA-176412 4.421020e-01 0.354 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.693646e-01 0.328 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.693646e-01 0.328 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.693646e-01 0.328 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.693646e-01 0.328 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.693646e-01 0.328 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.071094e-01 0.295 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 5.071094e-01 0.295 0 0
Netrin mediated repulsion signals R-HSA-418886 5.071094e-01 0.295 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.071094e-01 0.295 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.071094e-01 0.295 0 0
Recycling of eIF2:GDP R-HSA-72731 5.071094e-01 0.295 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 5.071094e-01 0.295 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.071094e-01 0.295 0 0
Transcription of the HIV genome R-HSA-167172 3.171827e-01 0.499 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.465104e-01 0.460 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.973764e-01 0.401 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.345965e-01 0.475 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.135208e-01 0.384 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.135208e-01 0.384 0 0
Translation initiation complex formation R-HSA-72649 3.665730e-01 0.436 0 0
Viral mRNA Translation R-HSA-192823 3.052175e-01 0.515 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.522179e-01 0.453 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.531730e-01 0.344 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.531730e-01 0.344 0 0
Attenuation phase R-HSA-3371568 4.066626e-01 0.391 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.697831e-01 0.569 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.227430e-01 0.374 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.227430e-01 0.374 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.227430e-01 0.374 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.788885e-01 0.320 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.145586e-01 0.382 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.145586e-01 0.382 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.070902e-01 0.390 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.117101e-01 0.291 0 0
Polymerase switching R-HSA-69091 5.117101e-01 0.291 0 0
Leading Strand Synthesis R-HSA-69109 5.117101e-01 0.291 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.117101e-01 0.291 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.117101e-01 0.291 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.369916e-01 0.360 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.854518e-01 0.314 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.854518e-01 0.314 0 0
IRS-mediated signalling R-HSA-112399 4.274332e-01 0.369 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.945206e-01 0.306 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.595431e-01 0.338 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.030416e-01 0.692 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.417276e-01 0.355 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.758664e-01 0.755 0 0
Insulin receptor signalling cascade R-HSA-74751 4.522843e-01 0.345 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.135208e-01 0.384 0 0
Signaling by FGFR3 R-HSA-5654741 1.981212e-01 0.703 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.729496e-01 0.762 0 0
G1/S Transition R-HSA-69206 2.195739e-01 0.658 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.759413e-01 0.559 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.759413e-01 0.559 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.191729e-01 0.659 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.729496e-01 0.762 0 0
Generation of second messenger molecules R-HSA-202433 1.832629e-01 0.737 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.367144e-01 0.473 0 0
Specification of the neural plate border R-HSA-9834899 3.872337e-01 0.412 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.468059e-01 0.460 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.455098e-01 0.610 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.363666e-01 0.473 0 0
DNA Double Strand Break Response R-HSA-5693606 3.000153e-01 0.523 0 0
MET promotes cell motility R-HSA-8875878 3.592341e-01 0.445 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.731240e-01 0.325 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.560932e-01 0.592 0 0
TCR signaling R-HSA-202403 2.647748e-01 0.577 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.827920e-01 0.738 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.553464e-01 0.593 0 0
Signalling to RAS R-HSA-167044 4.531730e-01 0.344 0 0
Ribosome-associated quality control R-HSA-9948299 3.284359e-01 0.484 0 0
Signaling by FGFR1 R-HSA-5654736 4.070902e-01 0.390 0 0
Prolonged ERK activation events R-HSA-169893 2.560932e-01 0.592 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.429965e-01 0.614 0 0
mRNA Editing R-HSA-75072 3.344535e-01 0.476 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.788885e-01 0.320 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.117101e-01 0.291 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.625147e-01 0.581 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.116282e-01 0.674 0 0
Meiosis R-HSA-1500620 1.746680e-01 0.758 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.000153e-01 0.523 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.935897e-01 0.307 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.693646e-01 0.328 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.788885e-01 0.320 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.563777e-01 0.341 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.801133e-01 0.744 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.801133e-01 0.744 0 0
RMTs methylate histone arginines R-HSA-3214858 2.755586e-01 0.560 0 0
Signal attenuation R-HSA-74749 1.827920e-01 0.738 0 0
Integration of provirus R-HSA-162592 2.534179e-01 0.596 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.897031e-01 0.538 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.045731e-01 0.393 0 0
Myogenesis R-HSA-525793 4.613561e-01 0.336 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.864029e-01 0.730 0 0
Interleukin-1 signaling R-HSA-9020702 3.569026e-01 0.447 0 0
Frs2-mediated activation R-HSA-170968 3.284793e-01 0.483 0 0
p75NTR signals via NF-kB R-HSA-193639 4.045731e-01 0.393 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.514438e-01 0.454 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.731240e-01 0.325 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.565204e-01 0.341 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.803115e-01 0.420 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.479771e-01 0.606 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.255236e-01 0.487 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.477600e-01 0.349 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.592341e-01 0.445 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.475270e-01 0.459 0 0
Regulated Necrosis R-HSA-5218859 3.171827e-01 0.499 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.718038e-01 0.566 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.429965e-01 0.614 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.945702e-01 0.404 0 0
Regulation of CDH11 function R-HSA-9762292 3.803115e-01 0.420 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.412764e-01 0.617 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.071094e-01 0.295 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.071094e-01 0.295 0 0
Stabilization of p53 R-HSA-69541 3.829020e-01 0.417 0 0
TNF signaling R-HSA-75893 2.078752e-01 0.682 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.066626e-01 0.391 0 0
Diseases of Immune System R-HSA-5260271 4.066626e-01 0.391 0 0
Triglyceride catabolism R-HSA-163560 3.125413e-01 0.505 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.045005e-01 0.689 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.243371e-01 0.649 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.718038e-01 0.566 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.340049e-01 0.476 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.884500e-01 0.540 0 0
Sodium/Proton exchangers R-HSA-425986 2.884500e-01 0.540 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.344535e-01 0.476 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.424257e-01 0.465 0 0
G2/M Checkpoints R-HSA-69481 1.850061e-01 0.733 0 0
Platelet calcium homeostasis R-HSA-418360 3.861785e-01 0.413 0 0
Sodium/Calcium exchangers R-HSA-425561 4.693646e-01 0.328 0 0
Passive transport by Aquaporins R-HSA-432047 4.788885e-01 0.320 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.117101e-01 0.291 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.480248e-01 0.349 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.207849e-01 0.494 0 0
Nuclear RNA decay R-HSA-9930044 3.468059e-01 0.460 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.078836e-01 0.512 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.842692e-01 0.735 0 0
Signal transduction by L1 R-HSA-445144 4.203682e-01 0.376 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.049397e-01 0.516 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.006076e-01 0.698 0 0
Toll-like Receptor Cascades R-HSA-168898 3.122196e-01 0.506 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.827920e-01 0.738 0 0
Repression of WNT target genes R-HSA-4641265 5.117101e-01 0.291 0 0
Gastrulation R-HSA-9758941 4.805726e-01 0.318 0 0
Autophagy R-HSA-9612973 4.221781e-01 0.375 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.310680e-01 0.480 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.049397e-01 0.516 0 0
G1 Phase R-HSA-69236 3.921208e-01 0.407 0 0
Cyclin D associated events in G1 R-HSA-69231 3.921208e-01 0.407 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.009293e-01 0.300 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.722186e-01 0.429 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.592341e-01 0.445 0 0
GPER1 signaling R-HSA-9634597 3.576811e-01 0.447 0 0
Ub-specific processing proteases R-HSA-5689880 2.444459e-01 0.612 0 0
Signaling by NOTCH4 R-HSA-9013694 4.239939e-01 0.373 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.149921e-01 0.668 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.149921e-01 0.668 0 0
Hedgehog 'off' state R-HSA-5610787 3.421611e-01 0.466 0 0
Downstream signal transduction R-HSA-186763 4.407718e-01 0.356 0 0
Cellular response to chemical stress R-HSA-9711123 4.613363e-01 0.336 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.008150e-01 0.397 0 0
GPVI-mediated activation cascade R-HSA-114604 2.024665e-01 0.694 0 0
DNA Repair R-HSA-73894 2.660257e-01 0.575 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.468662e-01 0.608 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.094420e-01 0.679 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.340049e-01 0.476 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.340049e-01 0.476 0 0
Calcineurin activates NFAT R-HSA-2025928 3.344535e-01 0.476 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.936133e-01 0.307 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.665886e-01 0.436 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.673284e-01 0.573 0 0
Signaling by FGFR in disease R-HSA-1226099 2.391120e-01 0.621 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.468059e-01 0.460 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.693646e-01 0.328 0 0
Ca2+ activated K+ channels R-HSA-1296052 5.071094e-01 0.295 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.318492e-01 0.365 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.788885e-01 0.320 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.776389e-01 0.321 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.945206e-01 0.306 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.031827e-01 0.394 0 0
Interleukin-17 signaling R-HSA-448424 1.837922e-01 0.736 0 0
Signaling by TGFB family members R-HSA-9006936 2.714035e-01 0.566 0 0
Host Interactions of HIV factors R-HSA-162909 4.841402e-01 0.315 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.255236e-01 0.487 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.894020e-01 0.538 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.777025e-01 0.750 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.494521e-01 0.603 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.730296e-01 0.564 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.745227e-01 0.324 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.138865e-01 0.670 0 0
Neuronal System R-HSA-112316 3.103310e-01 0.508 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.243371e-01 0.649 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.788885e-01 0.320 0 0
Interleukin-2 signaling R-HSA-9020558 4.254403e-01 0.371 0 0
mTORC1-mediated signalling R-HSA-166208 3.424257e-01 0.465 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.613561e-01 0.336 0 0
Selective autophagy R-HSA-9663891 4.835669e-01 0.316 0 0
Interleukin-1 family signaling R-HSA-446652 2.460212e-01 0.609 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.904594e-01 0.309 0 0
Transmission across Chemical Synapses R-HSA-112315 4.309810e-01 0.366 0 0
Interleukin-2 family signaling R-HSA-451927 1.832629e-01 0.737 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.227430e-01 0.374 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.249841e-01 0.648 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.945702e-01 0.404 0 0
Heme signaling R-HSA-9707616 3.083809e-01 0.511 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.421020e-01 0.354 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.541133e-01 0.343 0 0
Negative regulation of FLT3 R-HSA-9706369 2.560932e-01 0.592 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.128877e-01 0.505 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.421005e-01 0.466 0 0
Cardiac conduction R-HSA-5576891 3.705389e-01 0.431 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.864029e-01 0.730 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.534179e-01 0.596 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.249841e-01 0.648 0 0
Neurofascin interactions R-HSA-447043 4.524898e-01 0.344 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.038194e-01 0.517 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.731240e-01 0.325 0 0
NGF-stimulated transcription R-HSA-9031628 2.504262e-01 0.601 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.066626e-01 0.391 0 0
Aquaporin-mediated transport R-HSA-445717 3.938502e-01 0.405 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.304278e-01 0.366 0 0
Protein methylation R-HSA-8876725 4.045731e-01 0.393 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.115879e-01 0.506 0 0
Signaling by PTK6 R-HSA-8848021 4.328103e-01 0.364 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.328103e-01 0.364 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.141144e-01 0.669 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.078752e-01 0.682 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.465104e-01 0.460 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.744597e-01 0.427 0 0
Reproduction R-HSA-1474165 2.252864e-01 0.647 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.718038e-01 0.566 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.996996e-01 0.398 0 0
Regulation of PTEN localization R-HSA-8948747 2.429965e-01 0.614 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.340049e-01 0.476 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.884500e-01 0.540 0 0
Co-stimulation by ICOS R-HSA-9927354 2.884500e-01 0.540 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.344535e-01 0.476 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.945702e-01 0.404 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.945702e-01 0.404 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.936133e-01 0.307 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.936133e-01 0.307 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.539891e-01 0.451 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.254403e-01 0.371 0 0
FLT3 signaling in disease R-HSA-9682385 3.125413e-01 0.505 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.443805e-01 0.612 0 0
Protein hydroxylation R-HSA-9629569 4.203682e-01 0.376 0 0
Degradation of CDH1 R-HSA-9766229 3.788284e-01 0.422 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.066626e-01 0.391 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.775415e-01 0.557 0 0
Disorders of Developmental Biology R-HSA-9675151 4.788885e-01 0.320 0 0
Metalloprotease DUBs R-HSA-5689901 4.613561e-01 0.336 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.837956e-01 0.547 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.750348e-01 0.323 0 0
Signaling by TGFBR3 R-HSA-9839373 3.159945e-01 0.500 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.735091e-01 0.761 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.808239e-01 0.743 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.421005e-01 0.466 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.904594e-01 0.309 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.344535e-01 0.476 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.171827e-01 0.499 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.788885e-01 0.320 0 0
Oncogene Induced Senescence R-HSA-2559585 4.227430e-01 0.374 0 0
Stimuli-sensing channels R-HSA-2672351 2.401350e-01 0.620 0 0
LGI-ADAM interactions R-HSA-5682910 2.173208e-01 0.663 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.945702e-01 0.404 0 0
Signal regulatory protein family interactions R-HSA-391160 3.665886e-01 0.436 0 0
Syndecan interactions R-HSA-3000170 3.722186e-01 0.429 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.720279e-01 0.429 0 0
CHL1 interactions R-HSA-447041 5.071094e-01 0.295 0 0
Pervasive developmental disorders R-HSA-9005895 5.117101e-01 0.291 0 0
Disorders of Nervous System Development R-HSA-9697154 5.117101e-01 0.291 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.117101e-01 0.291 0 0
Kidney development R-HSA-9830369 4.001913e-01 0.398 0 0
PI Metabolism R-HSA-1483255 2.213426e-01 0.655 0 0
Sensory processing of sound R-HSA-9659379 3.163135e-01 0.500 0 0
Diseases of DNA repair R-HSA-9675135 3.159945e-01 0.500 0 0
Signaling by ALK R-HSA-201556 3.829020e-01 0.417 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.429965e-01 0.614 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.906185e-01 0.537 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.344535e-01 0.476 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.986465e-01 0.525 0 0
Glucose metabolism R-HSA-70326 2.409381e-01 0.618 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.328103e-01 0.364 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.011723e-01 0.696 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.843117e-01 0.546 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.627153e-01 0.581 0 0
Interleukin-15 signaling R-HSA-8983432 2.906185e-01 0.537 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.292240e-01 0.483 0 0
DSCAM interactions R-HSA-376172 4.936133e-01 0.307 0 0
Synthesis of PI R-HSA-1483226 4.254403e-01 0.371 0 0
Formation of the anterior neural plate R-HSA-9823739 4.045731e-01 0.393 0 0
OAS antiviral response R-HSA-8983711 5.117101e-01 0.291 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.854518e-01 0.314 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.850387e-01 0.314 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.259349e-01 0.646 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.049397e-01 0.516 0 0
Maturation of nucleoprotein R-HSA-9694631 2.277395e-01 0.643 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.945702e-01 0.404 0 0
Selenocysteine synthesis R-HSA-2408557 2.779213e-01 0.556 0 0
Nuclear import of Rev protein R-HSA-180746 3.973764e-01 0.401 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 2.718038e-01 0.566 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.936133e-01 0.307 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.421020e-01 0.354 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 5.071094e-01 0.295 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.071094e-01 0.295 0 0
Regulation of beta-cell development R-HSA-186712 1.758664e-01 0.755 0 0
Interleukin-7 signaling R-HSA-1266695 4.318492e-01 0.365 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.340049e-01 0.476 0 0
Leukotriene receptors R-HSA-391906 4.524898e-01 0.344 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.071094e-01 0.295 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.553189e-01 0.449 0 0
Influenza Infection R-HSA-168255 5.010502e-01 0.300 0 0
IRE1alpha activates chaperones R-HSA-381070 4.532939e-01 0.344 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.537371e-01 0.343 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.146901e-01 0.288 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.146901e-01 0.288 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.146901e-01 0.288 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.146901e-01 0.288 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.146901e-01 0.288 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.170322e-01 0.286 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.170322e-01 0.286 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.170322e-01 0.286 0 0
Pyroptosis R-HSA-5620971 5.190285e-01 0.285 0 0
Cellular response to starvation R-HSA-9711097 5.200250e-01 0.284 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.208025e-01 0.283 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.208025e-01 0.283 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.208025e-01 0.283 0 0
Nucleotide Excision Repair R-HSA-5696398 5.212047e-01 0.283 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.224185e-01 0.282 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.266372e-01 0.278 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.278936e-01 0.277 0 0
Signaling by ERBB4 R-HSA-1236394 5.302444e-01 0.276 0 0
Signaling by FGFR2 R-HSA-5654738 5.313519e-01 0.275 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.322978e-01 0.274 0 0
Inositol phosphate metabolism R-HSA-1483249 5.373041e-01 0.270 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.462732e-01 0.263 0 0
Aggrephagy R-HSA-9646399 5.464531e-01 0.262 0 0
Nucleosome assembly R-HSA-774815 5.465296e-01 0.262 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.465296e-01 0.262 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.465296e-01 0.262 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.465296e-01 0.262 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.465625e-01 0.262 0 0
Meiotic recombination R-HSA-912446 5.467356e-01 0.262 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.487588e-01 0.261 0 0
Mismatch Repair R-HSA-5358508 5.493070e-01 0.260 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.493070e-01 0.260 0 0
Nephron development R-HSA-9831926 5.493070e-01 0.260 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.493070e-01 0.260 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.503226e-01 0.259 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.521937e-01 0.258 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.521937e-01 0.258 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.521937e-01 0.258 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.521937e-01 0.258 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.521937e-01 0.258 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.553468e-01 0.255 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.580441e-01 0.253 0 0
Activation of RAS in B cells R-HSA-1169092 5.580441e-01 0.253 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 5.580441e-01 0.253 0 0
Formation of annular gap junctions R-HSA-196025 5.580441e-01 0.253 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.580441e-01 0.253 0 0
FGFR1b ligand binding and activation R-HSA-190370 5.580441e-01 0.253 0 0
Adrenoceptors R-HSA-390696 5.580441e-01 0.253 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.580441e-01 0.253 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.580441e-01 0.253 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 5.580441e-01 0.253 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 5.580441e-01 0.253 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.580441e-01 0.253 0 0
Interleukin-18 signaling R-HSA-9012546 5.580441e-01 0.253 0 0
Cilium Assembly R-HSA-5617833 5.597665e-01 0.252 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.660636e-01 0.247 0 0
UCH proteinases R-HSA-5689603 5.660636e-01 0.247 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.687161e-01 0.245 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.687161e-01 0.245 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.699851e-01 0.244 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.699851e-01 0.244 0 0
PLC-gamma1 signalling R-HSA-167021 5.728392e-01 0.242 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.728392e-01 0.242 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.728392e-01 0.242 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.728392e-01 0.242 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.728392e-01 0.242 0 0
Axonal growth stimulation R-HSA-209563 5.728392e-01 0.242 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.728392e-01 0.242 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.728392e-01 0.242 0 0
Invadopodia formation R-HSA-8941237 5.728392e-01 0.242 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.728392e-01 0.242 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.728392e-01 0.242 0 0
MET interacts with TNS proteins R-HSA-8875513 5.728392e-01 0.242 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.728392e-01 0.242 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.728392e-01 0.242 0 0
Histamine receptors R-HSA-390650 5.728392e-01 0.242 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.728392e-01 0.242 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.728392e-01 0.242 0 0
FasL/ CD95L signaling R-HSA-75157 5.728392e-01 0.242 0 0
Neutrophil degranulation R-HSA-6798695 5.738245e-01 0.241 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.775281e-01 0.238 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.815512e-01 0.235 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.818605e-01 0.235 0 0
Regulation of signaling by CBL R-HSA-912631 5.825802e-01 0.235 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.825802e-01 0.235 0 0
Other interleukin signaling R-HSA-449836 5.825802e-01 0.235 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.835817e-01 0.234 0 0
Hedgehog 'on' state R-HSA-5632684 5.844426e-01 0.233 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.868028e-01 0.232 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.904211e-01 0.229 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.904211e-01 0.229 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.906129e-01 0.229 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.906129e-01 0.229 0 0
cGMP effects R-HSA-418457 5.906129e-01 0.229 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.906129e-01 0.229 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.906129e-01 0.229 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.906129e-01 0.229 0 0
HDL assembly R-HSA-8963896 5.906129e-01 0.229 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.929531e-01 0.227 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.960996e-01 0.225 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.960996e-01 0.225 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.961989e-01 0.225 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.961989e-01 0.225 0 0
RUNX2 regulates bone development R-HSA-8941326 5.961989e-01 0.225 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.995458e-01 0.222 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.004551e-01 0.222 0 0
Budding and maturation of HIV virion R-HSA-162588 6.004551e-01 0.222 0 0
RNA Polymerase I Transcription R-HSA-73864 6.008015e-01 0.221 0 0
Gap junction degradation R-HSA-190873 6.051100e-01 0.218 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.051100e-01 0.218 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.051100e-01 0.218 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.051100e-01 0.218 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.051100e-01 0.218 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.051100e-01 0.218 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.051100e-01 0.218 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.051100e-01 0.218 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 6.051100e-01 0.218 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.062171e-01 0.217 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.062171e-01 0.217 0 0
Chromosome Maintenance R-HSA-73886 6.082980e-01 0.216 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.142940e-01 0.212 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.153040e-01 0.211 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.197575e-01 0.208 0 0
Degradation of AXIN R-HSA-4641257 6.199426e-01 0.208 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.199426e-01 0.208 0 0
Platelet degranulation R-HSA-114608 6.208667e-01 0.207 0 0
Erythropoietin activates RAS R-HSA-9027284 6.268347e-01 0.203 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.268347e-01 0.203 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.268347e-01 0.203 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.268347e-01 0.203 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.268347e-01 0.203 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.268347e-01 0.203 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.268347e-01 0.203 0 0
p38MAPK events R-HSA-171007 6.268347e-01 0.203 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.268347e-01 0.203 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.282548e-01 0.202 0 0
Signaling by NOTCH3 R-HSA-9012852 6.282548e-01 0.202 0 0
Signaling by Hedgehog R-HSA-5358351 6.318278e-01 0.199 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.322049e-01 0.199 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.337525e-01 0.198 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.337525e-01 0.198 0 0
PKR-mediated signaling R-HSA-9833482 6.342480e-01 0.198 0 0
MHC class II antigen presentation R-HSA-2132295 6.350471e-01 0.197 0 0
Mitochondrial biogenesis R-HSA-1592230 6.363417e-01 0.196 0 0
MTF1 activates gene expression R-HSA-5660489 6.396737e-01 0.194 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.396737e-01 0.194 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.396737e-01 0.194 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.396737e-01 0.194 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.396737e-01 0.194 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 6.396737e-01 0.194 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.396737e-01 0.194 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 6.396737e-01 0.194 0 0
Transmission across Electrical Synapses R-HSA-112307 6.396737e-01 0.194 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.396737e-01 0.194 0 0
Sensory perception of sour taste R-HSA-9729555 6.396737e-01 0.194 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.398567e-01 0.194 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.428986e-01 0.192 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.433323e-01 0.192 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.441571e-01 0.191 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.446426e-01 0.191 0 0
Lagging Strand Synthesis R-HSA-69186 6.446426e-01 0.191 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.446426e-01 0.191 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 6.446426e-01 0.191 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.473977e-01 0.189 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.482709e-01 0.188 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.482709e-01 0.188 0 0
Arachidonate production from DAG R-HSA-426048 6.482709e-01 0.188 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.482709e-01 0.188 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 6.482709e-01 0.188 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.482709e-01 0.188 0 0
Tandem pore domain potassium channels R-HSA-1296346 6.482709e-01 0.188 0 0
Signaling by Leptin R-HSA-2586552 6.482709e-01 0.188 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.522077e-01 0.186 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.579788e-01 0.182 0 0
DAP12 interactions R-HSA-2172127 6.579788e-01 0.182 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.600740e-01 0.180 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.600740e-01 0.180 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.600740e-01 0.180 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.607849e-01 0.180 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.607849e-01 0.180 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.607849e-01 0.180 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.612214e-01 0.180 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.668821e-01 0.176 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.682078e-01 0.175 0 0
Macroautophagy R-HSA-1632852 6.682078e-01 0.175 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.715765e-01 0.173 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.732873e-01 0.172 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.732873e-01 0.172 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.732873e-01 0.172 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.738245e-01 0.171 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 6.738245e-01 0.171 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.782334e-01 0.169 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.782334e-01 0.169 0 0
Ion channel transport R-HSA-983712 6.793932e-01 0.168 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.817298e-01 0.166 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.839906e-01 0.165 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.851398e-01 0.164 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.851398e-01 0.164 0 0
Telomere Extension By Telomerase R-HSA-171319 6.851398e-01 0.164 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.862916e-01 0.163 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.862916e-01 0.163 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.875965e-01 0.163 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.875965e-01 0.163 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.875965e-01 0.163 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.875965e-01 0.163 0 0
Formation of the posterior neural plate R-HSA-9832991 6.875965e-01 0.163 0 0
Bicarbonate transporters R-HSA-425381 6.875965e-01 0.163 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 6.875965e-01 0.163 0 0
Suppression of apoptosis R-HSA-9635465 6.875965e-01 0.163 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.902340e-01 0.161 0 0
Orc1 removal from chromatin R-HSA-68949 6.902877e-01 0.161 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.902877e-01 0.161 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.902877e-01 0.161 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.924383e-01 0.160 0 0
Phase 2 - plateau phase R-HSA-5576893 6.924383e-01 0.160 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.924383e-01 0.160 0 0
ER-Phagosome pathway R-HSA-1236974 6.926318e-01 0.159 0 0
Activation of AMPA receptors R-HSA-399710 6.960544e-01 0.157 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.960544e-01 0.157 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.960544e-01 0.157 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.960544e-01 0.157 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.960544e-01 0.157 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.960544e-01 0.157 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.960544e-01 0.157 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.960544e-01 0.157 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.960544e-01 0.157 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.960544e-01 0.157 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.960544e-01 0.157 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.960544e-01 0.157 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.960544e-01 0.157 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.960544e-01 0.157 0 0
Co-inhibition by BTLA R-HSA-9927353 6.960544e-01 0.157 0 0
Reelin signalling pathway R-HSA-8866376 6.960544e-01 0.157 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.960544e-01 0.157 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.960544e-01 0.157 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.962560e-01 0.157 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.962560e-01 0.157 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.962560e-01 0.157 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.977315e-01 0.156 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.002916e-01 0.155 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.002916e-01 0.155 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.002916e-01 0.155 0 0
Signaling by KIT in disease R-HSA-9669938 7.002916e-01 0.155 0 0
PCP/CE pathway R-HSA-4086400 7.010524e-01 0.154 0 0
Triglyceride metabolism R-HSA-8979227 7.013989e-01 0.154 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.060529e-01 0.151 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.066732e-01 0.151 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.066732e-01 0.151 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.083223e-01 0.150 0 0
mRNA Capping R-HSA-72086 7.089244e-01 0.149 0 0
DNA methylation R-HSA-5334118 7.089244e-01 0.149 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.089244e-01 0.149 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.164553e-01 0.145 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.176324e-01 0.144 0 0
Regulation of Apoptosis R-HSA-169911 7.176324e-01 0.144 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.176324e-01 0.144 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.181942e-01 0.144 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.181942e-01 0.144 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.181942e-01 0.144 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.181942e-01 0.144 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.181942e-01 0.144 0 0
Ca2+ pathway R-HSA-4086398 7.213631e-01 0.142 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.218098e-01 0.142 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.218098e-01 0.142 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.218098e-01 0.142 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.218098e-01 0.142 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.218098e-01 0.142 0 0
ERKs are inactivated R-HSA-202670 7.232301e-01 0.141 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.232301e-01 0.141 0 0
NF-kB is activated and signals survival R-HSA-209560 7.232301e-01 0.141 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.232301e-01 0.141 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.232301e-01 0.141 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 7.232301e-01 0.141 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.232301e-01 0.141 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.256482e-01 0.139 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.256669e-01 0.139 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.304192e-01 0.136 0 0
Activation of the pre-replicative complex R-HSA-68962 7.314175e-01 0.136 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.314175e-01 0.136 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.341262e-01 0.134 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.343662e-01 0.134 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.343930e-01 0.134 0 0
HSF1 activation R-HSA-3371511 7.379440e-01 0.132 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 7.379440e-01 0.132 0 0
Vesicle-mediated transport R-HSA-5653656 7.394317e-01 0.131 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 7.436158e-01 0.129 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.436158e-01 0.129 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.436158e-01 0.129 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.436158e-01 0.129 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.436158e-01 0.129 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.436158e-01 0.129 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.436158e-01 0.129 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.436158e-01 0.129 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.436158e-01 0.129 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.436158e-01 0.129 0 0
NGF-independant TRKA activation R-HSA-187024 7.436158e-01 0.129 0 0
Formation of the Editosome R-HSA-75094 7.436158e-01 0.129 0 0
Synthesis of PS R-HSA-1483101 7.436158e-01 0.129 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 7.436158e-01 0.129 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 7.436158e-01 0.129 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.436158e-01 0.129 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.436158e-01 0.129 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 7.436158e-01 0.129 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 7.436158e-01 0.129 0 0
TRAIL signaling R-HSA-75158 7.436158e-01 0.129 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 7.436158e-01 0.129 0 0
rRNA processing R-HSA-72312 7.447526e-01 0.128 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.465835e-01 0.127 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.465835e-01 0.127 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.465835e-01 0.127 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.489455e-01 0.126 0 0
Apoptotic factor-mediated response R-HSA-111471 7.489455e-01 0.126 0 0
Tie2 Signaling R-HSA-210993 7.489455e-01 0.126 0 0
Platelet sensitization by LDL R-HSA-432142 7.489455e-01 0.126 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.493696e-01 0.125 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.493696e-01 0.125 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.493696e-01 0.125 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.504245e-01 0.125 0 0
Integration of energy metabolism R-HSA-163685 7.509321e-01 0.124 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.526213e-01 0.123 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.526213e-01 0.123 0 0
Adipogenesis R-HSA-9843745 7.540581e-01 0.123 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.553642e-01 0.122 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.553642e-01 0.122 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.553642e-01 0.122 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.553642e-01 0.122 0 0
MET activates RAS signaling R-HSA-8851805 7.553642e-01 0.122 0 0
Estrogen biosynthesis R-HSA-193144 7.553642e-01 0.122 0 0
Degradation of DVL R-HSA-4641258 7.571904e-01 0.121 0 0
Signaling by NOTCH1 R-HSA-1980143 7.641654e-01 0.117 0 0
Hemostasis R-HSA-109582 7.681293e-01 0.115 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.714846e-01 0.113 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.714846e-01 0.113 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.714846e-01 0.113 0 0
DNA strand elongation R-HSA-69190 7.725498e-01 0.112 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.725498e-01 0.112 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.725498e-01 0.112 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.739164e-01 0.111 0 0
Ion transport by P-type ATPases R-HSA-936837 7.790898e-01 0.108 0 0
Proteasome assembly R-HSA-9907900 7.791562e-01 0.108 0 0
Amine ligand-binding receptors R-HSA-375280 7.791562e-01 0.108 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.837372e-01 0.106 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.837372e-01 0.106 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.837372e-01 0.106 0 0
Hydrolysis of LPE R-HSA-1483152 7.837372e-01 0.106 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.837372e-01 0.106 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.837372e-01 0.106 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.837372e-01 0.106 0 0
Abacavir transmembrane transport R-HSA-2161517 7.837372e-01 0.106 0 0
NADPH regeneration R-HSA-389542 7.837372e-01 0.106 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.837372e-01 0.106 0 0
Lipid particle organization R-HSA-8964572 7.837372e-01 0.106 0 0
CREB3 factors activate genes R-HSA-8874211 7.837372e-01 0.106 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.842213e-01 0.106 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.842213e-01 0.106 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.842213e-01 0.106 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.842213e-01 0.106 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.842213e-01 0.106 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.842213e-01 0.106 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.842213e-01 0.106 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.842213e-01 0.106 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.842213e-01 0.106 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.842213e-01 0.106 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.842213e-01 0.106 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.860394e-01 0.105 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.912260e-01 0.102 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.920353e-01 0.101 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.920353e-01 0.101 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.925244e-01 0.101 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.925244e-01 0.101 0 0
Cellular response to hypoxia R-HSA-1234174 7.927327e-01 0.101 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.950237e-01 0.100 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.950237e-01 0.100 0 0
Somitogenesis R-HSA-9824272 7.950237e-01 0.100 0 0
Synthesis of DNA R-HSA-69239 7.950773e-01 0.100 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.968118e-01 0.099 0 0
Signaling by NODAL R-HSA-1181150 7.968118e-01 0.099 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.968118e-01 0.099 0 0
Creatine metabolism R-HSA-71288 7.968118e-01 0.099 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.968118e-01 0.099 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.982332e-01 0.098 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.982332e-01 0.098 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.005557e-01 0.097 0 0
DNA Replication R-HSA-69306 8.015710e-01 0.096 0 0
Extension of Telomeres R-HSA-180786 8.018670e-01 0.096 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.022179e-01 0.096 0 0
Potassium Channels R-HSA-1296071 8.055978e-01 0.094 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.086473e-01 0.092 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.086473e-01 0.092 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.086473e-01 0.092 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.086814e-01 0.092 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.090656e-01 0.092 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.100122e-01 0.092 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.100400e-01 0.091 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.100400e-01 0.091 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.100400e-01 0.091 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.100400e-01 0.091 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.100400e-01 0.091 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.110744e-01 0.091 0 0
Packaging Of Telomere Ends R-HSA-171306 8.110744e-01 0.091 0 0
Cristae formation R-HSA-8949613 8.110744e-01 0.091 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.122428e-01 0.090 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.169214e-01 0.088 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.175818e-01 0.087 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.175818e-01 0.087 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.175818e-01 0.087 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 8.175818e-01 0.087 0 0
IFNG signaling activates MAPKs R-HSA-9732724 8.175818e-01 0.087 0 0
DAG1 core M1 glycosylations R-HSA-8932506 8.175818e-01 0.087 0 0
FGFR3b ligand binding and activation R-HSA-190371 8.175818e-01 0.087 0 0
PTK6 Expression R-HSA-8849473 8.175818e-01 0.087 0 0
mRNA Editing: C to U Conversion R-HSA-72200 8.175818e-01 0.087 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.175818e-01 0.087 0 0
VLDL clearance R-HSA-8964046 8.175818e-01 0.087 0 0
Activation of TRKA receptors R-HSA-187015 8.175818e-01 0.087 0 0
Glycoprotein hormones R-HSA-209822 8.175818e-01 0.087 0 0
Biosynthesis of maresin conjugates in tissue regeneration (MCTR) R-HSA-9026762 8.175818e-01 0.087 0 0
Maturation of replicase proteins R-HSA-9694301 8.175818e-01 0.087 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.177340e-01 0.087 0 0
Signaling by Insulin receptor R-HSA-74752 8.220322e-01 0.085 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.237735e-01 0.084 0 0
Circadian clock R-HSA-9909396 8.245657e-01 0.084 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.249538e-01 0.084 0 0
Signaling by NOTCH2 R-HSA-1980145 8.249538e-01 0.084 0 0
Mitophagy R-HSA-5205647 8.249538e-01 0.084 0 0
Signaling by FGFR R-HSA-190236 8.260700e-01 0.083 0 0
Leishmania infection R-HSA-9658195 8.271873e-01 0.082 0 0
Parasitic Infection Pathways R-HSA-9824443 8.271873e-01 0.082 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.275022e-01 0.082 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.286629e-01 0.082 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.286629e-01 0.082 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.330644e-01 0.079 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.330644e-01 0.079 0 0
Translesion synthesis by REV1 R-HSA-110312 8.330644e-01 0.079 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.330644e-01 0.079 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.330644e-01 0.079 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.330644e-01 0.079 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.330644e-01 0.079 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.331222e-01 0.079 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.367941e-01 0.077 0 0
Assembly Of The HIV Virion R-HSA-175474 8.367941e-01 0.077 0 0
Metal ion SLC transporters R-HSA-425410 8.374309e-01 0.077 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.379331e-01 0.077 0 0
HIV Transcription Initiation R-HSA-167161 8.379331e-01 0.077 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.379331e-01 0.077 0 0
Intra-Golgi traffic R-HSA-6811438 8.379331e-01 0.077 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.379331e-01 0.077 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.379331e-01 0.077 0 0
Translation of Structural Proteins R-HSA-9683701 8.379331e-01 0.077 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.448677e-01 0.073 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.448677e-01 0.073 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.457048e-01 0.073 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.461315e-01 0.073 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.461315e-01 0.073 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.461315e-01 0.073 0 0
Interleukin-9 signaling R-HSA-8985947 8.461315e-01 0.073 0 0
Fructose biosynthesis R-HSA-5652227 8.461315e-01 0.073 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.461315e-01 0.073 0 0
Alpha-defensins R-HSA-1462054 8.461315e-01 0.073 0 0
Signaling by NOTCH R-HSA-157118 8.464525e-01 0.072 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.511594e-01 0.070 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.511594e-01 0.070 0 0
Depyrimidination R-HSA-73928 8.511594e-01 0.070 0 0
Translation of Structural Proteins R-HSA-9694635 8.533994e-01 0.069 0 0
Translesion synthesis by POLI R-HSA-5656121 8.535365e-01 0.069 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.535365e-01 0.069 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.535365e-01 0.069 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.535365e-01 0.069 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.535365e-01 0.069 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.541081e-01 0.068 0 0
FGFR2 alternative splicing R-HSA-6803529 8.541081e-01 0.068 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.541081e-01 0.068 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.541081e-01 0.068 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.541257e-01 0.068 0 0
RNA Polymerase III Transcription R-HSA-74158 8.541257e-01 0.068 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.541257e-01 0.068 0 0
Downstream TCR signaling R-HSA-202424 8.574702e-01 0.067 0 0
Base Excision Repair R-HSA-73884 8.574702e-01 0.067 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.597598e-01 0.066 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.597598e-01 0.066 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.617979e-01 0.065 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.634887e-01 0.064 0 0
Defective pyroptosis R-HSA-9710421 8.634887e-01 0.064 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.634887e-01 0.064 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.645838e-01 0.063 0 0
Voltage gated Potassium channels R-HSA-1296072 8.671223e-01 0.062 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.671223e-01 0.062 0 0
Cleavage of the damaged purine R-HSA-110331 8.671223e-01 0.062 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.697942e-01 0.061 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.697942e-01 0.061 0 0
Formation of the ureteric bud R-HSA-9830674 8.697942e-01 0.061 0 0
Growth hormone receptor signaling R-HSA-982772 8.697942e-01 0.061 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.702144e-01 0.060 0 0
Interleukin-21 signaling R-HSA-9020958 8.702144e-01 0.060 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.702144e-01 0.060 0 0
Unwinding of DNA R-HSA-176974 8.702144e-01 0.060 0 0
WNT mediated activation of DVL R-HSA-201688 8.702144e-01 0.060 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 8.702144e-01 0.060 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.702144e-01 0.060 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.702144e-01 0.060 0 0
Degradation of GABA R-HSA-916853 8.702144e-01 0.060 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.702144e-01 0.060 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.702144e-01 0.060 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.702144e-01 0.060 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.702144e-01 0.060 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.712940e-01 0.060 0 0
Dual incision in TC-NER R-HSA-6782135 8.713340e-01 0.060 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.716913e-01 0.060 0 0
Translesion synthesis by POLK R-HSA-5655862 8.716913e-01 0.060 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.716913e-01 0.060 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.716913e-01 0.060 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.716913e-01 0.060 0 0
Synthesis of PG R-HSA-1483148 8.716913e-01 0.060 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.716913e-01 0.060 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.725387e-01 0.059 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.734130e-01 0.059 0 0
Cargo concentration in the ER R-HSA-5694530 8.734130e-01 0.059 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.734130e-01 0.059 0 0
Potential therapeutics for SARS R-HSA-9679191 8.758598e-01 0.058 0 0
Telomere Maintenance R-HSA-157579 8.761207e-01 0.057 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.778417e-01 0.057 0 0
Depurination R-HSA-73927 8.791278e-01 0.056 0 0
Signaling by MET R-HSA-6806834 8.806467e-01 0.055 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.827510e-01 0.054 0 0
Regulation of insulin secretion R-HSA-422356 8.837158e-01 0.054 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.839704e-01 0.054 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.839704e-01 0.054 0 0
Complex III assembly R-HSA-9865881 8.839704e-01 0.054 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.839704e-01 0.054 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.844821e-01 0.053 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.856105e-01 0.053 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.856105e-01 0.053 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.859019e-01 0.053 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.877525e-01 0.052 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.877525e-01 0.052 0 0
Parasite infection R-HSA-9664407 8.896364e-01 0.051 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.896364e-01 0.051 0 0
Leishmania phagocytosis R-HSA-9664417 8.896364e-01 0.051 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.901954e-01 0.051 0 0
Interferon gamma signaling R-HSA-877300 8.902366e-01 0.050 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.905290e-01 0.050 0 0
DNA replication initiation R-HSA-68952 8.905290e-01 0.050 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.905290e-01 0.050 0 0
Formation of apoptosome R-HSA-111458 8.905290e-01 0.050 0 0
Binding and entry of HIV virion R-HSA-173107 8.905290e-01 0.050 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.905290e-01 0.050 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.905290e-01 0.050 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.905290e-01 0.050 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.905290e-01 0.050 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.905290e-01 0.050 0 0
Maturation of spike protein R-HSA-9683686 8.905290e-01 0.050 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.905290e-01 0.050 0 0
Sperm Motility And Taxes R-HSA-1300642 8.905290e-01 0.050 0 0
Pexophagy R-HSA-9664873 8.905290e-01 0.050 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.905290e-01 0.050 0 0
Peptide hormone biosynthesis R-HSA-209952 8.905290e-01 0.050 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.962696e-01 0.048 0 0
Protein ubiquitination R-HSA-8852135 8.966553e-01 0.047 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.967525e-01 0.047 0 0
Hyaluronan degradation R-HSA-2160916 8.967525e-01 0.047 0 0
Developmental Cell Lineages R-HSA-9734767 8.982349e-01 0.047 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.003785e-01 0.046 0 0
Glycogen metabolism R-HSA-8982491 9.003785e-01 0.046 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.003785e-01 0.046 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.011289e-01 0.045 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.019305e-01 0.045 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.019305e-01 0.045 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.019305e-01 0.045 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.019305e-01 0.045 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.036371e-01 0.044 0 0
Gene Silencing by RNA R-HSA-211000 9.049707e-01 0.043 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.068145e-01 0.042 0 0
Signaling by PDGF R-HSA-186797 9.068145e-01 0.042 0 0
tRNA processing in the nucleus R-HSA-6784531 9.068145e-01 0.042 0 0
DAG1 core M3 glycosylations R-HSA-8932505 9.076649e-01 0.042 0 0
Conjugation of benzoate with glycine R-HSA-177135 9.076649e-01 0.042 0 0
vRNA Synthesis R-HSA-192814 9.076649e-01 0.042 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 9.076649e-01 0.042 0 0
vRNP Assembly R-HSA-192905 9.076649e-01 0.042 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 9.076649e-01 0.042 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 9.076649e-01 0.042 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 9.076649e-01 0.042 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 9.076649e-01 0.042 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 9.076649e-01 0.042 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 9.076649e-01 0.042 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.076854e-01 0.042 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.076854e-01 0.042 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.076854e-01 0.042 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.082525e-01 0.042 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.082525e-01 0.042 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.093595e-01 0.041 0 0
G alpha (z) signalling events R-HSA-418597 9.093595e-01 0.041 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.097303e-01 0.041 0 0
Maturation of spike protein R-HSA-9694548 9.097303e-01 0.041 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.097303e-01 0.041 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.144213e-01 0.039 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.144213e-01 0.039 0 0
Diseases of hemostasis R-HSA-9671793 9.144213e-01 0.039 0 0
Selenoamino acid metabolism R-HSA-2408522 9.156856e-01 0.038 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.161459e-01 0.038 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.170462e-01 0.038 0 0
Dual Incision in GG-NER R-HSA-5696400 9.171260e-01 0.038 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.171260e-01 0.038 0 0
Hyaluronan metabolism R-HSA-2142845 9.171260e-01 0.038 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.185782e-01 0.037 0 0
Insulin processing R-HSA-264876 9.185782e-01 0.037 0 0
DNA Damage Bypass R-HSA-73893 9.208362e-01 0.036 0 0
Gap junction trafficking and regulation R-HSA-157858 9.208362e-01 0.036 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 9.221193e-01 0.035 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 9.221193e-01 0.035 0 0
Plasmalogen biosynthesis R-HSA-75896 9.221193e-01 0.035 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.221193e-01 0.035 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.222245e-01 0.035 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.254057e-01 0.034 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.254057e-01 0.034 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.254057e-01 0.034 0 0
Negative regulation of MET activity R-HSA-6807004 9.254057e-01 0.034 0 0
Pregnenolone biosynthesis R-HSA-196108 9.254057e-01 0.034 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.254057e-01 0.034 0 0
PERK regulates gene expression R-HSA-381042 9.256931e-01 0.034 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.276384e-01 0.033 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.278318e-01 0.033 0 0
Pyrimidine salvage R-HSA-73614 9.278318e-01 0.033 0 0
Co-inhibition by PD-1 R-HSA-389948 9.302318e-01 0.031 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.333178e-01 0.030 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.343116e-01 0.030 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.343116e-01 0.030 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.343116e-01 0.030 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.343116e-01 0.030 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.343116e-01 0.030 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.343116e-01 0.030 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.343116e-01 0.030 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.343116e-01 0.030 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.343116e-01 0.030 0 0
SARS-CoV Infections R-HSA-9679506 9.345286e-01 0.029 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.345867e-01 0.029 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.350490e-01 0.029 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.350490e-01 0.029 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.350490e-01 0.029 0 0
Basigin interactions R-HSA-210991 9.350490e-01 0.029 0 0
Interferon Signaling R-HSA-913531 9.356547e-01 0.029 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.361097e-01 0.029 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.362198e-01 0.029 0 0
Platelet homeostasis R-HSA-418346 9.364573e-01 0.029 0 0
Adaptive Immune System R-HSA-1280218 9.396236e-01 0.027 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.406742e-01 0.027 0 0
GABA receptor activation R-HSA-977443 9.422243e-01 0.026 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.422243e-01 0.026 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.435019e-01 0.025 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.435019e-01 0.025 0 0
Processing of SMDT1 R-HSA-8949664 9.445958e-01 0.025 0 0
Chylomicron remodeling R-HSA-8963901 9.445958e-01 0.025 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.445958e-01 0.025 0 0
Interconversion of polyamines R-HSA-351200 9.445958e-01 0.025 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.445958e-01 0.025 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.445958e-01 0.025 0 0
Interleukin-6 signaling R-HSA-1059683 9.445958e-01 0.025 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.445958e-01 0.025 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.500938e-01 0.022 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.503699e-01 0.022 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.509007e-01 0.022 0 0
Fructose metabolism R-HSA-5652084 9.509007e-01 0.022 0 0
LDL clearance R-HSA-8964038 9.509007e-01 0.022 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.509007e-01 0.022 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.509007e-01 0.022 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.512304e-01 0.022 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.525236e-01 0.021 0 0
Prolactin receptor signaling R-HSA-1170546 9.532704e-01 0.021 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.532704e-01 0.021 0 0
Hydrolysis of LPC R-HSA-1483115 9.532704e-01 0.021 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.532704e-01 0.021 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.532704e-01 0.021 0 0
Physiological factors R-HSA-5578768 9.532704e-01 0.021 0 0
Malate-aspartate shuttle R-HSA-9856872 9.532704e-01 0.021 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.532704e-01 0.021 0 0
Ciprofloxacin ADME R-HSA-9793528 9.532704e-01 0.021 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.532704e-01 0.021 0 0
Zinc transporters R-HSA-435354 9.532704e-01 0.021 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.532704e-01 0.021 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.568969e-01 0.019 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.573682e-01 0.019 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.573682e-01 0.019 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.573682e-01 0.019 0 0
Carnitine shuttle R-HSA-200425 9.573682e-01 0.019 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.588287e-01 0.018 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.605873e-01 0.017 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.605873e-01 0.017 0 0
Signaling by Activin R-HSA-1502540 9.605873e-01 0.017 0 0
Biotin transport and metabolism R-HSA-196780 9.605873e-01 0.017 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.605873e-01 0.017 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.605873e-01 0.017 0 0
Protein repair R-HSA-5676934 9.605873e-01 0.017 0 0
Transport and metabolism of PAPS R-HSA-174362 9.605873e-01 0.017 0 0
Other semaphorin interactions R-HSA-416700 9.605873e-01 0.017 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.605873e-01 0.017 0 0
DNA Damage Reversal R-HSA-73942 9.605873e-01 0.017 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.630146e-01 0.016 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.630146e-01 0.016 0 0
G alpha (s) signalling events R-HSA-418555 9.646034e-01 0.016 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.667588e-01 0.015 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.667588e-01 0.015 0 0
Activation of SMO R-HSA-5635838 9.667588e-01 0.015 0 0
Fructose catabolism R-HSA-70350 9.667588e-01 0.015 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.667588e-01 0.015 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.667588e-01 0.015 0 0
Killing mechanisms R-HSA-9664420 9.667588e-01 0.015 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.667588e-01 0.015 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.674991e-01 0.014 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.679384e-01 0.014 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.679384e-01 0.014 0 0
G protein gated Potassium channels R-HSA-1296059 9.679384e-01 0.014 0 0
Phospholipid metabolism R-HSA-1483257 9.686863e-01 0.014 0 0
eNOS activation R-HSA-203615 9.699169e-01 0.013 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.699169e-01 0.013 0 0
Activation of GABAB receptors R-HSA-991365 9.701645e-01 0.013 0 0
GABA B receptor activation R-HSA-977444 9.701645e-01 0.013 0 0
Peroxisomal protein import R-HSA-9033241 9.706983e-01 0.013 0 0
The phototransduction cascade R-HSA-2514856 9.716156e-01 0.013 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.719642e-01 0.012 0 0
Galactose catabolism R-HSA-70370 9.719642e-01 0.012 0 0
Coenzyme A biosynthesis R-HSA-196783 9.719642e-01 0.012 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.719642e-01 0.012 0 0
Response to metal ions R-HSA-5660526 9.719642e-01 0.012 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.719642e-01 0.012 0 0
MET activates PTK2 signaling R-HSA-8874081 9.722275e-01 0.012 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.722275e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.735534e-01 0.012 0 0
Metabolism of polyamines R-HSA-351202 9.736053e-01 0.012 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.759598e-01 0.011 0 0
Signaling by BMP R-HSA-201451 9.759598e-01 0.011 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.759598e-01 0.011 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.763548e-01 0.010 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.763548e-01 0.010 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.763548e-01 0.010 0 0
Glycogen storage diseases R-HSA-3229121 9.763548e-01 0.010 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.763548e-01 0.010 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.763548e-01 0.010 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.763548e-01 0.010 0 0
Gap junction trafficking R-HSA-190828 9.764790e-01 0.010 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.767700e-01 0.010 0 0
Glycosphingolipid transport R-HSA-9845576 9.767700e-01 0.010 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.772855e-01 0.010 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.792045e-01 0.009 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.796119e-01 0.009 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.800579e-01 0.009 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.800579e-01 0.009 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.800579e-01 0.009 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.800579e-01 0.009 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.800579e-01 0.009 0 0
Biosynthesis of DHA-derived sulfido conjugates R-HSA-9026395 9.800579e-01 0.009 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.803896e-01 0.009 0 0
Immune System R-HSA-168256 9.805678e-01 0.009 0 0
Glucagon-type ligand receptors R-HSA-420092 9.820227e-01 0.008 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.821201e-01 0.008 0 0
Elastic fibre formation R-HSA-1566948 9.821201e-01 0.008 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.821528e-01 0.008 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.830163e-01 0.007 0 0
Conjugation of carboxylic acids R-HSA-159424 9.831813e-01 0.007 0 0
Amino Acid conjugation R-HSA-156587 9.831813e-01 0.007 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.831813e-01 0.007 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.831813e-01 0.007 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.831813e-01 0.007 0 0
Amyloid fiber formation R-HSA-977225 9.835957e-01 0.007 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.838396e-01 0.007 0 0
GPCR downstream signalling R-HSA-388396 9.838815e-01 0.007 0 0
Pentose phosphate pathway R-HSA-71336 9.843315e-01 0.007 0 0
RAS processing R-HSA-9648002 9.843315e-01 0.007 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.844685e-01 0.007 0 0
Intraflagellar transport R-HSA-5620924 9.855265e-01 0.006 0 0
Gluconeogenesis R-HSA-70263 9.855265e-01 0.006 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.858157e-01 0.006 0 0
Glycogen synthesis R-HSA-3322077 9.858157e-01 0.006 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.858157e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.861356e-01 0.006 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.862794e-01 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 9.864134e-01 0.006 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.865894e-01 0.006 0 0
G-protein activation R-HSA-202040 9.880375e-01 0.005 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.880375e-01 0.005 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.880375e-01 0.005 0 0
Phenylalanine metabolism R-HSA-8964208 9.880375e-01 0.005 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.880375e-01 0.005 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.880375e-01 0.005 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.880375e-01 0.005 0 0
DAG1 glycosylations R-HSA-8931838 9.884270e-01 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.885819e-01 0.005 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.887580e-01 0.005 0 0
HCMV Early Events R-HSA-9609690 9.892359e-01 0.005 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.895006e-01 0.005 0 0
Glutathione conjugation R-HSA-156590 9.898450e-01 0.004 0 0
Serine metabolism R-HSA-977347 9.899114e-01 0.004 0 0
Glutathione synthesis and recycling R-HSA-174403 9.899114e-01 0.004 0 0
Ribavirin ADME R-HSA-9755088 9.899114e-01 0.004 0 0
Viral Infection Pathways R-HSA-9824446 9.901800e-01 0.004 0 0
ABC transporter disorders R-HSA-5619084 9.904908e-01 0.004 0 0
Integrin cell surface interactions R-HSA-216083 9.904908e-01 0.004 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.908245e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.911071e-01 0.004 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.912000e-01 0.004 0 0
Heme degradation R-HSA-189483 9.913949e-01 0.004 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.914919e-01 0.004 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.914919e-01 0.004 0 0
Ethanol oxidation R-HSA-71384 9.914919e-01 0.004 0 0
Cellular hexose transport R-HSA-189200 9.914919e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.916885e-01 0.004 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.919368e-01 0.004 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.925853e-01 0.003 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.925853e-01 0.003 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.925853e-01 0.003 0 0
Gap junction assembly R-HSA-190861 9.925853e-01 0.003 0 0
Signal amplification R-HSA-392518 9.925853e-01 0.003 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.928248e-01 0.003 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.928248e-01 0.003 0 0
Biosynthesis of maresins R-HSA-9018682 9.928248e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.930057e-01 0.003 0 0
Innate Immune System R-HSA-168249 9.932806e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.936141e-01 0.003 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.939490e-01 0.003 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.939490e-01 0.003 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.939490e-01 0.003 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.939490e-01 0.003 0 0
Interleukin-6 family signaling R-HSA-6783589 9.939490e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.942903e-01 0.002 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.948971e-01 0.002 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.948971e-01 0.002 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.948971e-01 0.002 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.948971e-01 0.002 0 0
Fertilization R-HSA-1187000 9.948971e-01 0.002 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.948971e-01 0.002 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.948971e-01 0.002 0 0
Laminin interactions R-HSA-3000157 9.948971e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.949712e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.952694e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.952694e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.953451e-01 0.002 0 0
Urea cycle R-HSA-70635 9.956967e-01 0.002 0 0
Abacavir ADME R-HSA-2161522 9.956967e-01 0.002 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.956967e-01 0.002 0 0
Protein folding R-HSA-391251 9.957205e-01 0.002 0 0
HCMV Late Events R-HSA-9610379 9.958107e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.959283e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.959310e-01 0.002 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.963711e-01 0.002 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.963711e-01 0.002 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.963711e-01 0.002 0 0
Triglyceride biosynthesis R-HSA-75109 9.963711e-01 0.002 0 0
Synthesis of PE R-HSA-1483213 9.963711e-01 0.002 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.963711e-01 0.002 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.965015e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.965512e-01 0.002 0 0
Insulin receptor recycling R-HSA-77387 9.969398e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.969436e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.969931e-01 0.001 0 0
HCMV Infection R-HSA-9609646 9.971190e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.972327e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.973197e-01 0.001 0 0
Thyroxine biosynthesis R-HSA-209968 9.974194e-01 0.001 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.974194e-01 0.001 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.974194e-01 0.001 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.974194e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.974551e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.974751e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.975332e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.975734e-01 0.001 0 0
Neurotransmitter clearance R-HSA-112311 9.978238e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.978893e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.980950e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.981363e-01 0.001 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.981649e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.983767e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.984109e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.984172e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.984876e-01 0.001 0 0
Protein localization R-HSA-9609507 9.985416e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.985972e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.986878e-01 0.001 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.986951e-01 0.001 0 0
Recycling of bile acids and salts R-HSA-159418 9.986951e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.987511e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.987511e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.987929e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.988117e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.988620e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.988913e-01 0.000 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.988997e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.989080e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.989857e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.991155e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.991600e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.991662e-01 0.000 0 0
Neddylation R-HSA-8951664 9.991909e-01 0.000 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.992177e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.992420e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.992595e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.992719e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.992719e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.993506e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.993506e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993588e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.994224e-01 0.000 0 0
tRNA processing R-HSA-72306 9.994254e-01 0.000 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.994438e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.994438e-01 0.000 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.994438e-01 0.000 0 0
Metabolism of folate and pterines R-HSA-196757 9.994438e-01 0.000 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.995310e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.996045e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.997212e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997317e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997411e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.997630e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.997630e-01 0.000 0 0
Defensins R-HSA-1461973 9.998315e-01 0.000 0 0
Translation R-HSA-72766 9.998384e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.998579e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.998708e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.998802e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.998833e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.998970e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.998990e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999042e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.999149e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.999149e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999185e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999272e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999308e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999340e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999472e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999543e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999552e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.999570e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.999613e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999670e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999713e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999713e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999785e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999795e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999795e-01 0.000 0 0
Digestion R-HSA-8935690 9.999817e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999848e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999851e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999858e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999890e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999890e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999894e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999908e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999922e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999933e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999933e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999945e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999949e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999950e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999953e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999959e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999959e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999961e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999967e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999982e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999983e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999984e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999987e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999988e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999990e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999993e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999995e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999995e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999996e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999996e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999996e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999997e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999997e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999998e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999998e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 7.771561e-16 15.109 0 0
Cell Cycle, Mitotic R-HSA-69278 1.265654e-14 13.898 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.555178e-12 11.593 0 0
M Phase R-HSA-68886 1.104916e-11 10.957 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.110245e-11 10.507 0 0
Cell-Cell communication R-HSA-1500931 5.558864e-11 10.255 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.007721e-10 9.997 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.269854e-10 9.896 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.269854e-10 9.896 0 0
Axon guidance R-HSA-422475 2.948959e-10 9.530 0 0
Apoptotic execution phase R-HSA-75153 3.890114e-10 9.410 0 0
Cellular responses to stimuli R-HSA-8953897 4.684101e-10 9.329 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.089300e-10 9.092 0 0
Nervous system development R-HSA-9675108 1.034191e-09 8.985 0 0
Metabolism of RNA R-HSA-8953854 2.523303e-09 8.598 0 0
Cellular responses to stress R-HSA-2262752 3.385456e-09 8.470 0 0
Mitotic Prometaphase R-HSA-68877 1.027634e-08 7.988 0 0
Cell Cycle Checkpoints R-HSA-69620 1.060239e-08 7.975 0 0
Mitotic Anaphase R-HSA-68882 1.489203e-08 7.827 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.730978e-08 7.762 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.758134e-08 7.755 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.445332e-08 7.612 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.709354e-08 7.567 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.460795e-08 7.351 0 0
Cell junction organization R-HSA-446728 7.037542e-08 7.153 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.460762e-08 7.024 0 0
Translation initiation complex formation R-HSA-72649 1.038730e-07 6.983 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.382398e-07 6.859 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.761447e-07 6.754 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.887111e-07 6.724 0 0
Separation of Sister Chromatids R-HSA-2467813 1.927768e-07 6.715 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.202327e-07 6.657 0 0
Peptide chain elongation R-HSA-156902 2.615438e-07 6.582 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.342746e-07 6.476 0 0
Interleukin-12 signaling R-HSA-9020591 3.356738e-07 6.474 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.381717e-07 6.358 0 0
Signaling by ALK in cancer R-HSA-9700206 4.381717e-07 6.358 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.054028e-07 6.296 0 0
Cellular response to heat stress R-HSA-3371556 5.054028e-07 6.296 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.209588e-07 6.283 0 0
Interleukin-12 family signaling R-HSA-447115 6.056837e-07 6.218 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.282419e-07 6.138 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.800061e-07 6.056 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.800061e-07 6.056 0 0
Ribosome-associated quality control R-HSA-9948299 1.046522e-06 5.980 0 0
Chromatin organization R-HSA-4839726 1.238769e-06 5.907 0 0
Signaling by RAS mutants R-HSA-6802949 1.520337e-06 5.818 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.520337e-06 5.818 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.520337e-06 5.818 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.520337e-06 5.818 0 0
Eukaryotic Translation Termination R-HSA-72764 1.740253e-06 5.759 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.068541e-06 5.684 0 0
Signaling by ROBO receptors R-HSA-376176 2.403294e-06 5.619 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.857418e-06 5.544 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.857418e-06 5.544 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.955491e-06 5.529 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.120819e-06 5.506 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.120819e-06 5.506 0 0
mRNA Splicing R-HSA-72172 3.095438e-06 5.509 0 0
Chromatin modifying enzymes R-HSA-3247509 3.393593e-06 5.469 0 0
Adherens junctions interactions R-HSA-418990 4.127651e-06 5.384 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.330834e-06 5.363 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.490135e-06 5.348 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.232000e-06 5.281 0 0
Selenocysteine synthesis R-HSA-2408557 5.383167e-06 5.269 0 0
Cell-cell junction organization R-HSA-421270 6.023282e-06 5.220 0 0
HSF1-dependent transactivation R-HSA-3371571 6.054165e-06 5.218 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.934395e-06 5.159 0 0
Apoptosis R-HSA-109581 8.266581e-06 5.083 0 0
Regulation of CDH1 Function R-HSA-9764561 8.632479e-06 5.064 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.780080e-06 5.057 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.916785e-06 5.050 0 0
Influenza Infection R-HSA-168255 9.234641e-06 5.035 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.032596e-05 4.986 0 0
Striated Muscle Contraction R-HSA-390522 1.325401e-05 4.878 0 0
Viral mRNA Translation R-HSA-192823 1.885121e-05 4.725 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.920900e-05 4.716 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.960052e-05 4.708 0 0
rRNA processing R-HSA-72312 2.009459e-05 4.697 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.120015e-05 4.674 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.753024e-05 4.560 0 0
Attenuation phase R-HSA-3371568 2.898875e-05 4.538 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.130595e-05 4.504 0 0
Membrane Trafficking R-HSA-199991 3.371465e-05 4.472 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.552385e-05 4.449 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.794649e-05 4.421 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.832429e-05 4.417 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.023676e-05 4.395 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.572765e-05 4.340 0 0
Signaling by ERBB2 R-HSA-1227986 4.975368e-05 4.303 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.182401e-05 4.285 0 0
Programmed Cell Death R-HSA-5357801 5.426003e-05 4.266 0 0
Metalloprotease DUBs R-HSA-5689901 5.470512e-05 4.262 0 0
ESR-mediated signaling R-HSA-8939211 6.285652e-05 4.202 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.996703e-05 4.155 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.004022e-05 4.155 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.625175e-05 4.118 0 0
Nephrin family interactions R-HSA-373753 7.766688e-05 4.110 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.580151e-05 4.067 0 0
Cellular response to starvation R-HSA-9711097 9.268814e-05 4.033 0 0
RMTs methylate histone arginines R-HSA-3214858 1.022479e-04 3.990 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.025654e-04 3.989 0 0
S Phase R-HSA-69242 1.143195e-04 3.942 0 0
Nucleosome assembly R-HSA-774815 1.288429e-04 3.890 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.288429e-04 3.890 0 0
MAPK family signaling cascades R-HSA-5683057 1.288745e-04 3.890 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.404037e-04 3.853 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.413852e-04 3.850 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.447305e-04 3.839 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.447305e-04 3.839 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.625917e-04 3.789 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.814358e-04 3.741 0 0
EPH-Ephrin signaling R-HSA-2682334 2.042427e-04 3.690 0 0
Josephin domain DUBs R-HSA-5689877 2.349430e-04 3.629 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.349430e-04 3.629 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.799743e-04 3.553 0 0
HATs acetylate histones R-HSA-3214847 2.921008e-04 3.534 0 0
Cellular Senescence R-HSA-2559583 3.079014e-04 3.512 0 0
Signal Transduction R-HSA-162582 2.989200e-04 3.524 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.125652e-04 3.505 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.301621e-04 3.481 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.593991e-04 3.444 0 0
HDACs deacetylate histones R-HSA-3214815 3.690845e-04 3.433 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.037010e-04 3.394 0 0
Post NMDA receptor activation events R-HSA-438064 4.334352e-04 3.363 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.133010e-04 3.384 0 0
G2/M Checkpoints R-HSA-69481 4.407573e-04 3.356 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.414829e-04 3.355 0 0
MAP2K and MAPK activation R-HSA-5674135 4.515270e-04 3.345 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.679582e-04 3.330 0 0
Long-term potentiation R-HSA-9620244 5.338004e-04 3.273 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.443787e-04 3.264 0 0
G2/M Transition R-HSA-69275 5.552819e-04 3.255 0 0
RAF activation R-HSA-5673000 6.528569e-04 3.185 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.364552e-04 3.196 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.528569e-04 3.185 0 0
Signaling by PTK6 R-HSA-8848021 6.093970e-04 3.215 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.093970e-04 3.215 0 0
Selenoamino acid metabolism R-HSA-2408522 6.631481e-04 3.178 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.704199e-04 3.174 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.804597e-04 3.167 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.566922e-04 3.121 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.757827e-04 3.110 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.430129e-04 3.074 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.284894e-04 3.032 0 0
UCH proteinases R-HSA-5689603 8.598017e-04 3.066 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.021330e-04 3.045 0 0
Deubiquitination R-HSA-5688426 9.346975e-04 3.029 0 0
HSF1 activation R-HSA-3371511 1.021527e-03 2.991 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.081316e-03 2.966 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.182986e-03 2.927 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.213662e-03 2.916 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.225129e-03 2.912 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.255244e-03 2.901 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.319917e-03 2.879 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.368881e-03 2.864 0 0
Late endosomal microautophagy R-HSA-9615710 1.484289e-03 2.828 0 0
Semaphorin interactions R-HSA-373755 1.467596e-03 2.833 0 0
Mitotic Prophase R-HSA-68875 1.368976e-03 2.864 0 0
G1/S Transition R-HSA-69206 1.362607e-03 2.866 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.569834e-03 2.804 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.569834e-03 2.804 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.569834e-03 2.804 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.569834e-03 2.804 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.578307e-03 2.802 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.540831e-03 2.812 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.540831e-03 2.812 0 0
Ub-specific processing proteases R-HSA-5689880 1.705909e-03 2.768 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.664270e-03 2.779 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.629524e-03 2.788 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.550042e-03 2.810 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.763320e-03 2.754 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.763320e-03 2.754 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.763320e-03 2.754 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.822792e-03 2.739 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.846453e-03 2.734 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.856423e-03 2.731 0 0
PECAM1 interactions R-HSA-210990 1.856423e-03 2.731 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.905271e-03 2.720 0 0
Muscle contraction R-HSA-397014 1.921131e-03 2.716 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.004567e-03 2.698 0 0
DNA Repair R-HSA-73894 2.019845e-03 2.695 0 0
HIV Life Cycle R-HSA-162587 2.041650e-03 2.690 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.063469e-03 2.685 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.065957e-03 2.685 0 0
Degradation of CDH1 R-HSA-9766229 2.100527e-03 2.678 0 0
Translation R-HSA-72766 2.134651e-03 2.671 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.208728e-03 2.656 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.292199e-03 2.640 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.527104e-03 2.597 0 0
DNA Replication R-HSA-69306 2.523865e-03 2.598 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.527104e-03 2.597 0 0
DNA Double Strand Break Response R-HSA-5693606 2.667246e-03 2.574 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.673562e-03 2.573 0 0
TCR signaling R-HSA-202403 2.683363e-03 2.571 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.714685e-03 2.566 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.760034e-03 2.559 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.848269e-03 2.545 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.848269e-03 2.545 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.848269e-03 2.545 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.915013e-03 2.535 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.954530e-03 2.530 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.070667e-03 2.513 0 0
Regulation of signaling by CBL R-HSA-912631 3.115983e-03 2.506 0 0
L1CAM interactions R-HSA-373760 3.277068e-03 2.485 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.531439e-03 2.452 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.432708e-03 2.464 0 0
Orc1 removal from chromatin R-HSA-68949 3.432708e-03 2.464 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.774921e-03 2.423 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.569804e-03 2.447 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.774921e-03 2.423 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.531240e-03 2.452 0 0
Recycling pathway of L1 R-HSA-437239 3.689727e-03 2.433 0 0
HIV Infection R-HSA-162906 3.634856e-03 2.440 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.774921e-03 2.423 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.733379e-03 2.428 0 0
Signaling by Interleukins R-HSA-449147 3.735125e-03 2.428 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.848750e-03 2.415 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.850773e-03 2.414 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.007427e-03 2.397 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.007427e-03 2.397 0 0
Homology Directed Repair R-HSA-5693538 4.012267e-03 2.397 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.031030e-03 2.395 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.049929e-03 2.393 0 0
Protein folding R-HSA-391251 4.255459e-03 2.371 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.301559e-03 2.366 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.364773e-03 2.360 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.656230e-03 2.332 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.946455e-03 2.306 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.097461e-03 2.293 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.189399e-03 2.285 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.189399e-03 2.285 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.189399e-03 2.285 0 0
Dual Incision in GG-NER R-HSA-5696400 5.189684e-03 2.285 0 0
Mitophagy R-HSA-5205647 5.189684e-03 2.285 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.190690e-03 2.285 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.227564e-03 2.282 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.310342e-03 2.275 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.629039e-03 2.250 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.629039e-03 2.250 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.347558e-03 2.272 0 0
Nucleotide Excision Repair R-HSA-5696398 5.756417e-03 2.240 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.372623e-03 2.270 0 0
Chromosome Maintenance R-HSA-73886 5.372623e-03 2.270 0 0
Meiosis R-HSA-1500620 6.004772e-03 2.222 0 0
Signaling by Hippo R-HSA-2028269 6.167588e-03 2.210 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.872167e-03 2.231 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.004772e-03 2.222 0 0
Signaling by NOTCH R-HSA-157118 5.622407e-03 2.250 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.220398e-03 2.206 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.216242e-03 2.206 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.897687e-03 2.229 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.224271e-03 2.206 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.562630e-03 2.183 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.562630e-03 2.183 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.562630e-03 2.183 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.574185e-03 2.182 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.737593e-03 2.171 0 0
FLT3 Signaling R-HSA-9607240 6.931031e-03 2.159 0 0
Synthesis of DNA R-HSA-69239 7.032351e-03 2.153 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.359996e-03 2.133 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.359996e-03 2.133 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.788920e-03 2.109 0 0
Regulation of PTEN localization R-HSA-8948747 8.077791e-03 2.093 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.120549e-03 2.090 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.135768e-03 2.090 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.467369e-03 2.072 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.467369e-03 2.072 0 0
Signaling by VEGF R-HSA-194138 8.486094e-03 2.071 0 0
Co-inhibition by PD-1 R-HSA-389948 8.542131e-03 2.068 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.664372e-03 2.062 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.778594e-03 2.057 0 0
Cellular response to chemical stress R-HSA-9711123 9.022035e-03 2.045 0 0
Meiotic synapsis R-HSA-1221632 9.069198e-03 2.042 0 0
Smooth Muscle Contraction R-HSA-445355 9.069198e-03 2.042 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.087224e-02 1.964 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.087224e-02 1.964 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.431197e-03 2.025 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.072297e-02 1.970 0 0
PTEN Regulation R-HSA-6807070 1.095960e-02 1.960 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.084340e-02 1.965 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.087224e-02 1.964 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.072297e-02 1.970 0 0
DCC mediated attractive signaling R-HSA-418885 9.431197e-03 2.025 0 0
NF-kB is activated and signals survival R-HSA-209560 1.087224e-02 1.964 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.012788e-02 1.994 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.689470e-03 2.014 0 0
Interferon Signaling R-HSA-913531 1.099359e-02 1.959 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.053692e-02 1.977 0 0
Selective autophagy R-HSA-9663891 9.334158e-03 2.030 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.370403e-03 2.028 0 0
Defective pyroptosis R-HSA-9710421 1.103564e-02 1.957 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.012788e-02 1.994 0 0
p75NTR signals via NF-kB R-HSA-193639 9.431197e-03 2.025 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.038318e-02 1.984 0 0
Diseases of programmed cell death R-HSA-9645723 9.334158e-03 2.030 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.152787e-02 1.938 0 0
Signaling by NOTCH3 R-HSA-9012852 1.184250e-02 1.927 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.184743e-02 1.926 0 0
Sensory processing of sound R-HSA-9659379 1.189616e-02 1.925 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.201730e-02 1.920 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.201730e-02 1.920 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.208417e-02 1.918 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.208417e-02 1.918 0 0
Neutrophil degranulation R-HSA-6798695 1.219247e-02 1.914 0 0
Negative regulation of FLT3 R-HSA-9706369 1.219879e-02 1.914 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.237987e-02 1.907 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.257721e-02 1.900 0 0
Negative regulation of MET activity R-HSA-6807004 1.257721e-02 1.900 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.270074e-02 1.896 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.275787e-02 1.894 0 0
G1 Phase R-HSA-69236 1.275787e-02 1.894 0 0
Cyclin D associated events in G1 R-HSA-69231 1.275787e-02 1.894 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.313630e-02 1.882 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.313630e-02 1.882 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.313630e-02 1.882 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.320144e-02 1.879 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.344923e-02 1.871 0 0
Signaling by EGFR R-HSA-177929 1.345742e-02 1.871 0 0
Heme signaling R-HSA-9707616 1.356199e-02 1.868 0 0
Activation of the pre-replicative complex R-HSA-68962 1.413485e-02 1.850 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.413485e-02 1.850 0 0
Vesicle-mediated transport R-HSA-5653656 1.438167e-02 1.842 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.449373e-02 1.839 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.470752e-02 1.832 0 0
Protein ubiquitination R-HSA-8852135 1.497477e-02 1.825 0 0
Centrosome maturation R-HSA-380287 1.497477e-02 1.825 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.505695e-02 1.822 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.540261e-02 1.812 0 0
Oncogene Induced Senescence R-HSA-2559585 1.540261e-02 1.812 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.550837e-02 1.809 0 0
Autophagy R-HSA-9612973 1.571285e-02 1.804 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.582909e-02 1.801 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.721787e-02 1.764 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.721787e-02 1.764 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.721787e-02 1.764 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.721787e-02 1.764 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.721787e-02 1.764 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.895244e-02 1.722 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.895244e-02 1.722 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.797222e-02 1.745 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.710639e-02 1.767 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.936170e-02 1.713 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.719568e-02 1.765 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.750971e-02 1.757 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.721787e-02 1.764 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.654438e-02 1.781 0 0
RNA Polymerase I Transcription R-HSA-73864 2.044281e-02 1.689 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.887870e-02 1.724 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.721787e-02 1.764 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.886224e-02 1.724 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.967769e-02 1.706 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.895244e-02 1.722 0 0
FLT3 signaling in disease R-HSA-9682385 1.795044e-02 1.746 0 0
Maturation of protein E R-HSA-9694493 1.721787e-02 1.764 0 0
Maturation of protein E R-HSA-9683683 1.721787e-02 1.764 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.721787e-02 1.764 0 0
Signaling by TGFB family members R-HSA-9006936 2.075845e-02 1.683 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.079892e-02 1.682 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.095111e-02 1.679 0 0
Macroautophagy R-HSA-1632852 2.109238e-02 1.676 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.137073e-02 1.670 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.168148e-02 1.664 0 0
Kinesins R-HSA-983189 2.168148e-02 1.664 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.178427e-02 1.662 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.187979e-02 1.660 0 0
Regulation of CDH11 function R-HSA-9762292 2.240899e-02 1.650 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.240899e-02 1.650 0 0
Viral Infection Pathways R-HSA-9824446 2.259934e-02 1.646 0 0
mTORC1-mediated signalling R-HSA-166208 2.288289e-02 1.640 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.288289e-02 1.640 0 0
Signaling by KIT in disease R-HSA-9669938 2.288289e-02 1.640 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.297925e-02 1.639 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.314799e-02 1.635 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.395021e-02 1.621 0 0
Ephrin signaling R-HSA-3928664 2.395021e-02 1.621 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.409153e-02 1.618 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.409153e-02 1.618 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.409153e-02 1.618 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.409153e-02 1.618 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.409153e-02 1.618 0 0
Regulation of KIT signaling R-HSA-1433559 2.409153e-02 1.618 0 0
Signaling by FGFR4 R-HSA-5654743 2.448309e-02 1.611 0 0
PKR-mediated signaling R-HSA-9833482 2.486207e-02 1.604 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.486207e-02 1.604 0 0
Signaling by FGFR2 R-HSA-5654738 2.486207e-02 1.604 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.508206e-02 1.601 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.508206e-02 1.601 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.508206e-02 1.601 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.508206e-02 1.601 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.508206e-02 1.601 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.508206e-02 1.601 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.508206e-02 1.601 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.512321e-02 1.600 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.512321e-02 1.600 0 0
Nef and signal transduction R-HSA-164944 2.512321e-02 1.600 0 0
HIV elongation arrest and recovery R-HSA-167287 2.520774e-02 1.598 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.520774e-02 1.598 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.520774e-02 1.598 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.565277e-02 1.591 0 0
Signaling by NOTCH4 R-HSA-9013694 2.565277e-02 1.591 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.748062e-02 1.561 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.828164e-02 1.548 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.917135e-02 1.535 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.917135e-02 1.535 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.947595e-02 1.531 0 0
DNA methylation R-HSA-5334118 2.950902e-02 1.530 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.950902e-02 1.530 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.018815e-02 1.520 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.018815e-02 1.520 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.018815e-02 1.520 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.018815e-02 1.520 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.018815e-02 1.520 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.110635e-02 1.507 0 0
Meiotic recombination R-HSA-912446 3.117931e-02 1.506 0 0
Aggrephagy R-HSA-9646399 3.133166e-02 1.504 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.133166e-02 1.504 0 0
Signaling by FGFR3 R-HSA-5654741 3.143014e-02 1.503 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.239672e-02 1.489 0 0
Neurodegenerative Diseases R-HSA-8863678 3.239672e-02 1.489 0 0
Regulation of gap junction activity R-HSA-191650 3.761418e-02 1.425 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 3.761418e-02 1.425 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.761418e-02 1.425 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.489733e-02 1.457 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.489733e-02 1.457 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.489733e-02 1.457 0 0
Prolonged ERK activation events R-HSA-169893 3.721498e-02 1.429 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.968903e-02 1.401 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.888494e-02 1.410 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.888494e-02 1.410 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.727724e-02 1.429 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.556224e-02 1.449 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.556224e-02 1.449 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.544535e-02 1.450 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.544535e-02 1.450 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.169068e-02 1.380 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.761418e-02 1.425 0 0
Budding and maturation of HIV virion R-HSA-162588 3.959763e-02 1.402 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.320487e-02 1.364 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.544535e-02 1.450 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.046913e-02 1.393 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.780684e-02 1.422 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.721498e-02 1.429 0 0
Host Interactions of HIV factors R-HSA-162909 3.454510e-02 1.462 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.644001e-02 1.438 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.959763e-02 1.402 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.179957e-02 1.379 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.430257e-02 1.354 0 0
Co-stimulation by CD28 R-HSA-389356 4.434247e-02 1.353 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.509560e-02 1.346 0 0
Ca-dependent events R-HSA-111996 4.519491e-02 1.345 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.520812e-02 1.345 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.542569e-02 1.343 0 0
G0 and Early G1 R-HSA-1538133 4.542569e-02 1.343 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.562329e-02 1.341 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.562329e-02 1.341 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.563783e-02 1.341 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.601504e-02 1.337 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.610205e-02 1.336 0 0
MAP kinase activation R-HSA-450294 4.618509e-02 1.335 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.658598e-02 1.332 0 0
RSK activation R-HSA-444257 4.658598e-02 1.332 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.658598e-02 1.332 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.658598e-02 1.332 0 0
Modulation by Mtb of host immune system R-HSA-9637628 4.658598e-02 1.332 0 0
Signaling by ERBB4 R-HSA-1236394 4.659698e-02 1.332 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.659698e-02 1.332 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.744250e-02 1.324 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.744250e-02 1.324 0 0
Disorders of Nervous System Development R-HSA-9697154 4.744250e-02 1.324 0 0
Pervasive developmental disorders R-HSA-9005895 4.744250e-02 1.324 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.744250e-02 1.324 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.744250e-02 1.324 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.744250e-02 1.324 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.744250e-02 1.324 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.784979e-02 1.320 0 0
Regulation of TP53 Activity R-HSA-5633007 4.915832e-02 1.308 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.926362e-02 1.307 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.936033e-02 1.307 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.936033e-02 1.307 0 0
Signaling by SCF-KIT R-HSA-1433557 5.062319e-02 1.296 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.079107e-02 1.294 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.120937e-02 1.291 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.120937e-02 1.291 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.120937e-02 1.291 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.120937e-02 1.291 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.179904e-02 1.286 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 5.216140e-02 1.283 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.216140e-02 1.283 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.216140e-02 1.283 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.257386e-02 1.279 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.282879e-02 1.277 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.474860e-02 1.262 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.474860e-02 1.262 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.474860e-02 1.262 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.474860e-02 1.262 0 0
Signaling by NOTCH1 R-HSA-1980143 5.528513e-02 1.257 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.570494e-02 1.254 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.570494e-02 1.254 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.626501e-02 1.250 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.647438e-02 1.248 0 0
Netrin-1 signaling R-HSA-373752 5.647438e-02 1.248 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.018814e-02 1.220 0 0
Gap junction degradation R-HSA-190873 6.018814e-02 1.220 0 0
Frs2-mediated activation R-HSA-170968 5.840316e-02 1.234 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.428144e-02 1.074 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.418354e-02 1.193 0 0
Notch-HLH transcription pathway R-HSA-350054 5.752168e-02 1.240 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.752168e-02 1.240 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.518349e-02 1.124 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.518349e-02 1.124 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.700834e-02 1.174 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.700834e-02 1.174 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.623231e-02 1.179 0 0
EGFR downregulation R-HSA-182971 8.550592e-02 1.068 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.550592e-02 1.068 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.472014e-02 1.189 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.472014e-02 1.189 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.948042e-02 1.158 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.948042e-02 1.158 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.669301e-02 1.176 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.669301e-02 1.176 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.664832e-02 1.115 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.325456e-02 1.135 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.807826e-02 1.236 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.433950e-02 1.129 0 0
Transcription of the HIV genome R-HSA-167172 8.510134e-02 1.070 0 0
Signaling by NOTCH2 R-HSA-1980145 6.623231e-02 1.179 0 0
Translesion Synthesis by POLH R-HSA-110320 7.518349e-02 1.124 0 0
CaM pathway R-HSA-111997 8.296748e-02 1.081 0 0
Calmodulin induced events R-HSA-111933 8.296748e-02 1.081 0 0
Circadian clock R-HSA-9909396 6.601696e-02 1.180 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.207512e-02 1.142 0 0
Downstream TCR signaling R-HSA-202424 6.287561e-02 1.202 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.700834e-02 1.174 0 0
Translesion synthesis by REV1 R-HSA-110312 8.428144e-02 1.074 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.472014e-02 1.189 0 0
Unwinding of DNA R-HSA-176974 6.018814e-02 1.220 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.428144e-02 1.074 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.522554e-02 1.186 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.426884e-02 1.129 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.426884e-02 1.129 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.408179e-02 1.075 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.646189e-02 1.117 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.623258e-02 1.118 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.623258e-02 1.118 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.623258e-02 1.118 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.623258e-02 1.118 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.510134e-02 1.070 0 0
Stabilization of p53 R-HSA-69541 5.786518e-02 1.238 0 0
G alpha (12/13) signalling events R-HSA-416482 6.503343e-02 1.187 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.442810e-02 1.128 0 0
Protein methylation R-HSA-8876725 8.428144e-02 1.074 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.591823e-02 1.120 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.068902e-02 1.151 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.623258e-02 1.118 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.433950e-02 1.129 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.752168e-02 1.240 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.840316e-02 1.234 0 0
Signal regulatory protein family interactions R-HSA-391160 7.068902e-02 1.151 0 0
Glycogen metabolism R-HSA-8982491 6.472014e-02 1.189 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.815003e-02 1.235 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.385771e-02 1.076 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.275764e-02 1.202 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.018814e-02 1.220 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.418354e-02 1.193 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.993510e-02 1.097 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.428144e-02 1.074 0 0
Pexophagy R-HSA-9664873 7.566132e-02 1.121 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 8.578268e-02 1.067 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 8.578268e-02 1.067 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.669377e-02 1.062 0 0
Signal transduction by L1 R-HSA-445144 8.718545e-02 1.060 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.718545e-02 1.060 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.830265e-02 1.054 0 0
MTOR signalling R-HSA-165159 8.830265e-02 1.054 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.830265e-02 1.054 0 0
Glycolysis R-HSA-70171 8.942837e-02 1.049 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.009891e-02 1.045 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.220598e-02 1.035 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 9.292749e-02 1.032 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.535319e-02 1.021 0 0
Signaling by FGFR1 R-HSA-5654736 9.535319e-02 1.021 0 0
DNA strand elongation R-HSA-69190 9.576885e-02 1.019 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.717780e-02 1.012 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.717780e-02 1.012 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 9.794606e-02 1.009 0 0
Signaling by LTK in cancer R-HSA-9842640 9.794606e-02 1.009 0 0
CREB phosphorylation R-HSA-199920 9.794606e-02 1.009 0 0
Translesion synthesis by POLI R-HSA-5656121 9.914448e-02 1.004 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.914448e-02 1.004 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.918455e-02 1.004 0 0
Interleukin-17 signaling R-HSA-448424 9.918455e-02 1.004 0 0
SARS-CoV Infections R-HSA-9679506 1.001469e-01 0.999 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.001720e-01 0.999 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.001720e-01 0.999 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.020226e-01 0.991 0 0
Protein localization R-HSA-9609507 1.053622e-01 0.977 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.067000e-01 0.972 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.067000e-01 0.972 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.067000e-01 0.972 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.109136e-01 0.955 0 0
Packaging Of Telomere Ends R-HSA-171306 1.109136e-01 0.955 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.109136e-01 0.955 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.109136e-01 0.955 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.118793e-01 0.951 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.118793e-01 0.951 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.118793e-01 0.951 0 0
Dual incision in TC-NER R-HSA-6782135 1.121076e-01 0.950 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.124114e-01 0.949 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.124114e-01 0.949 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.124114e-01 0.949 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.124114e-01 0.949 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.141160e-01 0.943 0 0
Assembly Of The HIV Virion R-HSA-175474 1.141160e-01 0.943 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.141160e-01 0.943 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.141757e-01 0.942 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.142740e-01 0.942 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.142740e-01 0.942 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.152266e-01 0.938 0 0
Translesion synthesis by POLK R-HSA-5655862 1.152266e-01 0.938 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.152266e-01 0.938 0 0
Disorders of Developmental Biology R-HSA-9675151 1.152266e-01 0.938 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.152266e-01 0.938 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.152266e-01 0.938 0 0
DAG and IP3 signaling R-HSA-1489509 1.164387e-01 0.934 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.164387e-01 0.934 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.164387e-01 0.934 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.164387e-01 0.934 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.182878e-01 0.927 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.182878e-01 0.927 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.182878e-01 0.927 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.192278e-01 0.924 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.192278e-01 0.924 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.210864e-01 0.917 0 0
Gene expression (Transcription) R-HSA-74160 1.215282e-01 0.915 0 0
Signaling by FGFR R-HSA-190236 1.216642e-01 0.915 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.216642e-01 0.915 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.216642e-01 0.915 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.216642e-01 0.915 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.233632e-01 0.909 0 0
HIV Transcription Elongation R-HSA-167169 1.233632e-01 0.909 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.233632e-01 0.909 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.233632e-01 0.909 0 0
Generation of second messenger molecules R-HSA-202433 1.233632e-01 0.909 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.233632e-01 0.909 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.233867e-01 0.909 0 0
Recycling of eIF2:GDP R-HSA-72731 1.233867e-01 0.909 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.233867e-01 0.909 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.233867e-01 0.909 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.240987e-01 0.906 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.240987e-01 0.906 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.240987e-01 0.906 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.240987e-01 0.906 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.249835e-01 0.903 0 0
Rab regulation of trafficking R-HSA-9007101 1.251812e-01 0.902 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.258699e-01 0.900 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.154953e-01 0.667 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.154953e-01 0.667 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.154953e-01 0.667 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.154953e-01 0.667 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.154953e-01 0.667 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.154953e-01 0.667 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.655985e-01 0.781 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.655985e-01 0.781 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.655985e-01 0.781 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.655985e-01 0.781 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.655985e-01 0.781 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.090550e-01 0.680 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.090550e-01 0.680 0 0
Type I hemidesmosome assembly R-HSA-446107 1.509178e-01 0.821 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.509178e-01 0.821 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.509178e-01 0.821 0 0
Formation of annular gap junctions R-HSA-196025 1.509178e-01 0.821 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.509178e-01 0.821 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.323859e-01 0.878 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.323859e-01 0.878 0 0
Regulation of IFNG signaling R-HSA-877312 1.323859e-01 0.878 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.323859e-01 0.878 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.323859e-01 0.878 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.323859e-01 0.878 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.323859e-01 0.878 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.801731e-01 0.744 0 0
ARMS-mediated activation R-HSA-170984 1.801731e-01 0.744 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.801731e-01 0.744 0 0
Calcineurin activates NFAT R-HSA-2025928 1.801731e-01 0.744 0 0
ALK mutants bind TKIs R-HSA-9700645 1.801731e-01 0.744 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.542992e-01 0.812 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.542992e-01 0.812 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.542992e-01 0.812 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.542992e-01 0.812 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.107920e-01 0.676 0 0
2-LTR circle formation R-HSA-164843 2.107920e-01 0.676 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.107920e-01 0.676 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.324629e-01 0.878 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.324629e-01 0.878 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.324629e-01 0.878 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.324629e-01 0.878 0 0
FGFR2 alternative splicing R-HSA-6803529 1.289820e-01 0.889 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.424291e-01 0.615 0 0
Signaling by APC mutants R-HSA-4839744 2.424291e-01 0.615 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.424291e-01 0.615 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.424291e-01 0.615 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.424291e-01 0.615 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.016953e-01 0.695 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.016953e-01 0.695 0 0
Deadenylation of mRNA R-HSA-429947 1.612979e-01 0.792 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.902856e-01 0.721 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.268383e-01 0.644 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 2.268383e-01 0.644 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.268383e-01 0.644 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 1.305167e-01 0.884 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.522414e-01 0.817 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.527160e-01 0.597 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.527160e-01 0.597 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.527160e-01 0.597 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.268123e-01 0.897 0 0
Cristae formation R-HSA-8949613 2.153895e-01 0.667 0 0
mRNA 3'-end processing R-HSA-72187 1.987115e-01 0.702 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.356215e-01 0.628 0 0
HCMV Early Events R-HSA-9609690 2.450868e-01 0.611 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.927909e-01 0.715 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.927909e-01 0.715 0 0
DNA Damage Bypass R-HSA-73893 1.607828e-01 0.794 0 0
Polo-like kinase mediated events R-HSA-156711 1.507767e-01 0.822 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.348658e-01 0.870 0 0
Integrin signaling R-HSA-354192 1.996164e-01 0.700 0 0
PERK regulates gene expression R-HSA-381042 1.433672e-01 0.844 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.927909e-01 0.715 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.966932e-01 0.706 0 0
Telomere Maintenance R-HSA-157579 1.714379e-01 0.766 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.542992e-01 0.812 0 0
TGFBR3 expression R-HSA-9839394 1.786408e-01 0.748 0 0
Nuclear import of Rev protein R-HSA-180746 1.305167e-01 0.884 0 0
PLC beta mediated events R-HSA-112043 1.402233e-01 0.853 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.107920e-01 0.676 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.324629e-01 0.878 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.996164e-01 0.700 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.348658e-01 0.870 0 0
Formation of apoptosome R-HSA-111458 2.107920e-01 0.676 0 0
Cellular response to hypoxia R-HSA-1234174 1.829882e-01 0.738 0 0
Signalling to ERKs R-HSA-187687 1.433672e-01 0.844 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.323859e-01 0.878 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.153895e-01 0.667 0 0
Dopamine receptors R-HSA-390651 1.655985e-01 0.781 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.522414e-01 0.817 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.786408e-01 0.748 0 0
ER-Phagosome pathway R-HSA-1236974 1.471824e-01 0.832 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.500763e-01 0.602 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.500763e-01 0.602 0 0
ERK/MAPK targets R-HSA-198753 2.112885e-01 0.675 0 0
Myogenesis R-HSA-525793 1.966932e-01 0.706 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.064381e-01 0.685 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.376692e-01 0.861 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.301471e-01 0.638 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.334847e-01 0.875 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.368906e-01 0.625 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.469042e-01 0.833 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.090550e-01 0.680 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.433672e-01 0.844 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.433672e-01 0.844 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.527160e-01 0.597 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.348658e-01 0.870 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.348658e-01 0.870 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.000185e-01 0.699 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.483797e-01 0.605 0 0
G-protein mediated events R-HSA-112040 2.064381e-01 0.685 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.441491e-01 0.841 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.090550e-01 0.680 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.501173e-01 0.824 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.016953e-01 0.695 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.376692e-01 0.861 0 0
Opioid Signalling R-HSA-111885 1.688036e-01 0.773 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.144177e-01 0.669 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.674130e-01 0.776 0 0
Cilium Assembly R-HSA-5617833 1.521906e-01 0.818 0 0
Signaling by WNT R-HSA-195721 2.093874e-01 0.679 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.409928e-01 0.618 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.107920e-01 0.676 0 0
Signal attenuation R-HSA-74749 2.107920e-01 0.676 0 0
Degradation of DVL R-HSA-4641258 1.708363e-01 0.767 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.725137e-01 0.763 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.000185e-01 0.699 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.996164e-01 0.700 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.339941e-01 0.631 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.892724e-01 0.723 0 0
Platelet degranulation R-HSA-114608 2.099192e-01 0.678 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.556379e-01 0.808 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.684773e-01 0.773 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.580151e-01 0.801 0 0
Inhibition of PKR R-HSA-169131 2.154953e-01 0.667 0 0
MTF1 activates gene expression R-HSA-5660489 1.655985e-01 0.781 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.655985e-01 0.781 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.090550e-01 0.680 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.801731e-01 0.744 0 0
Bicarbonate transporters R-HSA-425381 2.424291e-01 0.615 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.568160e-01 0.805 0 0
Degradation of AXIN R-HSA-4641257 1.708363e-01 0.767 0 0
TBC/RABGAPs R-HSA-8854214 1.725137e-01 0.763 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.346611e-01 0.630 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.000185e-01 0.699 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.483797e-01 0.605 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.054587e-01 0.687 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.996164e-01 0.700 0 0
Gene Silencing by RNA R-HSA-211000 1.424448e-01 0.846 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.451950e-01 0.610 0 0
OAS antiviral response R-HSA-8983711 1.323859e-01 0.878 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.284450e-01 0.891 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.348658e-01 0.870 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.917807e-01 0.717 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.192499e-01 0.659 0 0
Interleukin-6 signaling R-HSA-1059683 1.542992e-01 0.812 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.519165e-01 0.818 0 0
Downstream signal transduction R-HSA-186763 1.674130e-01 0.776 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.801731e-01 0.744 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.107920e-01 0.676 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.289820e-01 0.889 0 0
Suppression of apoptosis R-HSA-9635465 2.424291e-01 0.615 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.966932e-01 0.706 0 0
Amyloid fiber formation R-HSA-977225 1.999562e-01 0.699 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.090550e-01 0.680 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.305167e-01 0.884 0 0
Regulation of Apoptosis R-HSA-169911 1.433672e-01 0.844 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.483797e-01 0.605 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.483797e-01 0.605 0 0
Death Receptor Signaling R-HSA-73887 2.083107e-01 0.681 0 0
Signaling by MET R-HSA-6806834 1.892724e-01 0.723 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.346611e-01 0.630 0 0
Glucose metabolism R-HSA-70326 2.483735e-01 0.605 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.343666e-01 0.630 0 0
Other interleukin signaling R-HSA-449836 1.700821e-01 0.769 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.323859e-01 0.878 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.323859e-01 0.878 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.329881e-01 0.633 0 0
G1/S-Specific Transcription R-HSA-69205 1.568160e-01 0.805 0 0
Reproduction R-HSA-1474165 2.461993e-01 0.609 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.329881e-01 0.633 0 0
CASP4 inflammasome assembly R-HSA-9948001 2.107920e-01 0.676 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.507767e-01 0.822 0 0
Hedgehog 'on' state R-HSA-5632684 1.704149e-01 0.768 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.323859e-01 0.878 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.801731e-01 0.744 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.503674e-01 0.823 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.700821e-01 0.769 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.380610e-01 0.623 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.090550e-01 0.680 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.305167e-01 0.884 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.527160e-01 0.597 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.832192e-01 0.737 0 0
Glycogen synthesis R-HSA-3322077 1.902856e-01 0.721 0 0
Regulation of BACH1 activity R-HSA-9708530 2.268383e-01 0.644 0 0
Translation of Structural Proteins R-HSA-9683701 2.483797e-01 0.605 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.507767e-01 0.822 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.339941e-01 0.631 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.534798e-01 0.596 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.534798e-01 0.596 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.534798e-01 0.596 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.534798e-01 0.596 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.534798e-01 0.596 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.544372e-01 0.594 0 0
Ion homeostasis R-HSA-5578775 2.545046e-01 0.594 0 0
TNF signaling R-HSA-75893 2.545046e-01 0.594 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.545046e-01 0.594 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.552802e-01 0.593 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.565392e-01 0.591 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.571795e-01 0.590 0 0
Gap junction trafficking and regulation R-HSA-157858 2.598541e-01 0.585 0 0
Ion transport by P-type ATPases R-HSA-936837 2.629675e-01 0.580 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.629675e-01 0.580 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 2.651196e-01 0.577 0 0
RNA Polymerase II Transcription R-HSA-73857 2.670926e-01 0.573 0 0
RET signaling R-HSA-8853659 2.701454e-01 0.568 0 0
RUNX2 regulates bone development R-HSA-8941326 2.701454e-01 0.568 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.746459e-01 0.561 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.746459e-01 0.561 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.747601e-01 0.561 0 0
Activation of RAC1 R-HSA-428540 2.747601e-01 0.561 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.747601e-01 0.561 0 0
ERKs are inactivated R-HSA-202670 2.747601e-01 0.561 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.747601e-01 0.561 0 0
Integration of provirus R-HSA-162592 2.747601e-01 0.561 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.747601e-01 0.561 0 0
Signaling by AXIN mutants R-HSA-4839735 2.747601e-01 0.561 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.747601e-01 0.561 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 2.780597e-01 0.556 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.780597e-01 0.556 0 0
Syndecan interactions R-HSA-3000170 2.780597e-01 0.556 0 0
Growth hormone receptor signaling R-HSA-982772 2.780597e-01 0.556 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.791599e-01 0.554 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.791599e-01 0.554 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.791599e-01 0.554 0 0
Glycogen storage diseases R-HSA-3229121 2.791599e-01 0.554 0 0
Ca2+ pathway R-HSA-4086398 2.836038e-01 0.547 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.842018e-01 0.546 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.887542e-01 0.539 0 0
Cleavage of the damaged purine R-HSA-110331 2.887542e-01 0.539 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.892294e-01 0.539 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.916941e-01 0.535 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.916941e-01 0.535 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.952146e-01 0.530 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.952146e-01 0.530 0 0
Trafficking of AMPA receptors R-HSA-399719 2.952146e-01 0.530 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.980845e-01 0.526 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.980845e-01 0.526 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.980845e-01 0.526 0 0
Metabolism of non-coding RNA R-HSA-194441 2.994070e-01 0.524 0 0
snRNP Assembly R-HSA-191859 2.994070e-01 0.524 0 0
Peroxisomal protein import R-HSA-9033241 2.994070e-01 0.524 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.012229e-01 0.521 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.012229e-01 0.521 0 0
Generic Transcription Pathway R-HSA-212436 3.041550e-01 0.517 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.051543e-01 0.515 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.051543e-01 0.515 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.051543e-01 0.515 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.051543e-01 0.515 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.051543e-01 0.515 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.051543e-01 0.515 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.051543e-01 0.515 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.051543e-01 0.515 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.051543e-01 0.515 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 3.051543e-01 0.515 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.051543e-01 0.515 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.051543e-01 0.515 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.051543e-01 0.515 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.051543e-01 0.515 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 3.051543e-01 0.515 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.051543e-01 0.515 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.051543e-01 0.515 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.051543e-01 0.515 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.051543e-01 0.515 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.051543e-01 0.515 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.060073e-01 0.514 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.060073e-01 0.514 0 0
Mismatch Repair R-HSA-5358508 3.060073e-01 0.514 0 0
GAB1 signalosome R-HSA-180292 3.060073e-01 0.514 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.060073e-01 0.514 0 0
Apoptotic factor-mediated response R-HSA-111471 3.060073e-01 0.514 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.060073e-01 0.514 0 0
Platelet sensitization by LDL R-HSA-432142 3.060073e-01 0.514 0 0
HCMV Infection R-HSA-9609646 3.071451e-01 0.513 0 0
Polymerase switching R-HSA-69091 3.074865e-01 0.512 0 0
Leading Strand Synthesis R-HSA-69109 3.074865e-01 0.512 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.074865e-01 0.512 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.074865e-01 0.512 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.076468e-01 0.512 0 0
Depurination R-HSA-73927 3.076468e-01 0.512 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.079795e-01 0.511 0 0
Neurexins and neuroligins R-HSA-6794361 3.079795e-01 0.511 0 0
Interferon alpha/beta signaling R-HSA-909733 3.081830e-01 0.511 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.107625e-01 0.508 0 0
tRNA Aminoacylation R-HSA-379724 3.148128e-01 0.502 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.151352e-01 0.502 0 0
Cytoprotection by HMOX1 R-HSA-9707564 3.156411e-01 0.501 0 0
Developmental Biology R-HSA-1266738 3.194455e-01 0.496 0 0
Base Excision Repair R-HSA-73884 3.195194e-01 0.496 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.204296e-01 0.494 0 0
Interleukin-7 signaling R-HSA-1266695 3.246680e-01 0.489 0 0
Tight junction interactions R-HSA-420029 3.246680e-01 0.489 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.303909e-01 0.481 0 0
Mitochondrial biogenesis R-HSA-1592230 3.305620e-01 0.481 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.331028e-01 0.477 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.331028e-01 0.477 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.331028e-01 0.477 0 0
Rap1 signalling R-HSA-392517 3.331028e-01 0.477 0 0
The NLRP3 inflammasome R-HSA-844456 3.331028e-01 0.477 0 0
Adipogenesis R-HSA-9843745 3.342777e-01 0.476 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.348339e-01 0.475 0 0
Signaling by TGFBR3 R-HSA-9839373 3.348339e-01 0.475 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.348339e-01 0.475 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.371443e-01 0.472 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.371443e-01 0.472 0 0
G-protein beta:gamma signalling R-HSA-397795 3.371443e-01 0.472 0 0
Nuclear RNA decay R-HSA-9930044 3.371443e-01 0.472 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.371443e-01 0.472 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.371443e-01 0.472 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.371443e-01 0.472 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.403374e-01 0.468 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.403374e-01 0.468 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.403374e-01 0.468 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 3.403374e-01 0.468 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.403374e-01 0.468 0 0
Maturation of nucleoprotein R-HSA-9683610 3.403374e-01 0.468 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.422482e-01 0.466 0 0
SOS-mediated signalling R-HSA-112412 3.422482e-01 0.466 0 0
Netrin mediated repulsion signals R-HSA-418886 3.422482e-01 0.466 0 0
CHL1 interactions R-HSA-447041 3.422482e-01 0.466 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.450160e-01 0.462 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.460681e-01 0.461 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.461128e-01 0.461 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.462953e-01 0.461 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.482962e-01 0.458 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.482962e-01 0.458 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.482962e-01 0.458 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.482962e-01 0.458 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.533274e-01 0.452 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.533274e-01 0.452 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.533274e-01 0.452 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.583645e-01 0.446 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.603004e-01 0.443 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 3.603004e-01 0.443 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.603004e-01 0.443 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.603004e-01 0.443 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.603004e-01 0.443 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.603004e-01 0.443 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.652091e-01 0.437 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.654910e-01 0.437 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.654910e-01 0.437 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.654910e-01 0.437 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.680689e-01 0.434 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.720131e-01 0.429 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.730714e-01 0.428 0 0
Malate-aspartate shuttle R-HSA-9856872 3.730714e-01 0.428 0 0
Zinc transporters R-HSA-435354 3.730714e-01 0.428 0 0
Non-canonical inflammasome activation R-HSA-9686114 3.730714e-01 0.428 0 0
Hedgehog 'off' state R-HSA-5610787 3.732992e-01 0.428 0 0
ABC-family proteins mediated transport R-HSA-382556 3.732992e-01 0.428 0 0
NRAGE signals death through JNK R-HSA-193648 3.747630e-01 0.426 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 3.796642e-01 0.421 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.796642e-01 0.421 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.803283e-01 0.420 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.845710e-01 0.415 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.845710e-01 0.415 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.845710e-01 0.415 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.845710e-01 0.415 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.845710e-01 0.415 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.845710e-01 0.415 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.845710e-01 0.415 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.845710e-01 0.415 0 0
Intra-Golgi traffic R-HSA-6811438 3.849866e-01 0.415 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.850952e-01 0.414 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.854894e-01 0.414 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.854894e-01 0.414 0 0
phospho-PLA2 pathway R-HSA-111995 3.854894e-01 0.414 0 0
Interleukin-9 signaling R-HSA-8985947 3.854894e-01 0.414 0 0
Sodium/Proton exchangers R-HSA-425986 3.854894e-01 0.414 0 0
Adrenoceptors R-HSA-390696 3.854894e-01 0.414 0 0
Interleukin-1 signaling R-HSA-9020702 3.860984e-01 0.413 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.868975e-01 0.412 0 0
Lagging Strand Synthesis R-HSA-69186 3.874640e-01 0.412 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.874640e-01 0.412 0 0
Basigin interactions R-HSA-210991 3.874640e-01 0.412 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.874640e-01 0.412 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.874640e-01 0.412 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.880158e-01 0.411 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.880158e-01 0.411 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.888391e-01 0.410 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.917004e-01 0.407 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.957288e-01 0.403 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.957288e-01 0.403 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.957288e-01 0.403 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.957288e-01 0.403 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.987067e-01 0.399 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.009785e-01 0.397 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.045052e-01 0.393 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.045052e-01 0.393 0 0
Depyrimidination R-HSA-73928 4.045052e-01 0.393 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.054757e-01 0.392 0 0
Erythropoietin activates RAS R-HSA-9027284 4.054757e-01 0.392 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.054757e-01 0.392 0 0
G beta:gamma signalling through BTK R-HSA-8964315 4.054757e-01 0.392 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.054757e-01 0.392 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.054757e-01 0.392 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.054757e-01 0.392 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.054757e-01 0.392 0 0
Signaling by FGFR in disease R-HSA-1226099 4.107133e-01 0.386 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.107537e-01 0.386 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.193587e-01 0.377 0 0
Platelet calcium homeostasis R-HSA-418360 4.193587e-01 0.377 0 0
DARPP-32 events R-HSA-180024 4.193587e-01 0.377 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.251672e-01 0.371 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.251672e-01 0.371 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.274422e-01 0.369 0 0
Lipophagy R-HSA-9613354 4.274422e-01 0.369 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.274422e-01 0.369 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.274422e-01 0.369 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.274422e-01 0.369 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.274422e-01 0.369 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.274422e-01 0.369 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.274422e-01 0.369 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.274422e-01 0.369 0 0
Interleukin-1 processing R-HSA-448706 4.274422e-01 0.369 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.373663e-01 0.359 0 0
Phosphorylation of the APC/C R-HSA-176412 4.373663e-01 0.359 0 0
Activation of SMO R-HSA-5635838 4.373663e-01 0.359 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.411999e-01 0.355 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.431017e-01 0.353 0 0
Proteasome assembly R-HSA-9907900 4.434218e-01 0.353 0 0
Gap junction trafficking R-HSA-190828 4.434218e-01 0.353 0 0
Signaling by NTRKs R-HSA-166520 4.536809e-01 0.343 0 0
Axonal growth stimulation R-HSA-209563 4.549150e-01 0.342 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.549150e-01 0.342 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.549150e-01 0.342 0 0
MET activates PTPN11 R-HSA-8865999 4.549150e-01 0.342 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.549150e-01 0.342 0 0
MET interacts with TNS proteins R-HSA-8875513 4.549150e-01 0.342 0 0
Histamine receptors R-HSA-390650 4.549150e-01 0.342 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.594440e-01 0.338 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.594440e-01 0.338 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.627303e-01 0.335 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.627303e-01 0.335 0 0
Somitogenesis R-HSA-9824272 4.627303e-01 0.335 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.660516e-01 0.332 0 0
Ion channel transport R-HSA-983712 4.662417e-01 0.331 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.675562e-01 0.330 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.675562e-01 0.330 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.675562e-01 0.330 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.675562e-01 0.330 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.678365e-01 0.330 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.678365e-01 0.330 0 0
Interleukin-27 signaling R-HSA-9020956 4.678365e-01 0.330 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.678365e-01 0.330 0 0
Signaling by Leptin R-HSA-2586552 4.678365e-01 0.330 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.678365e-01 0.330 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.685862e-01 0.329 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.685862e-01 0.329 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.692611e-01 0.329 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.699953e-01 0.328 0 0
Mitochondrial protein import R-HSA-1268020 4.762273e-01 0.322 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.818832e-01 0.317 0 0
Diseases of DNA repair R-HSA-9675135 4.818832e-01 0.317 0 0
RAS processing R-HSA-9648002 4.851917e-01 0.314 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.851917e-01 0.314 0 0
Signaling by WNT in cancer R-HSA-4791275 4.889749e-01 0.311 0 0
Stimuli-sensing channels R-HSA-2672351 4.890529e-01 0.311 0 0
Interleukin-6 family signaling R-HSA-6783589 4.934464e-01 0.307 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.990038e-01 0.302 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.990038e-01 0.302 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.990038e-01 0.302 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.057177e-01 0.296 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.057177e-01 0.296 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.057177e-01 0.296 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.064805e-01 0.295 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.064805e-01 0.295 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.064805e-01 0.295 0 0
Interleukin-2 signaling R-HSA-9020558 5.064805e-01 0.295 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.064805e-01 0.295 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.115334e-01 0.291 0 0
Signaling by Hedgehog R-HSA-5358351 5.133237e-01 0.290 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.141468e-01 0.289 0 0
Alternative complement activation R-HSA-173736 5.172222e-01 0.286 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.172222e-01 0.286 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.172222e-01 0.286 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.172222e-01 0.286 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.172222e-01 0.286 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 5.172222e-01 0.286 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.187911e-01 0.285 0 0
HDMs demethylate histones R-HSA-3214842 5.187911e-01 0.285 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.187911e-01 0.285 0 0
Gluconeogenesis R-HSA-70263 5.195700e-01 0.284 0 0
Metal ion SLC transporters R-HSA-425410 5.195700e-01 0.284 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.285114e-01 0.277 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.285114e-01 0.277 0 0
Tie2 Signaling R-HSA-210993 5.285114e-01 0.277 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.285114e-01 0.277 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.321398e-01 0.274 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.336730e-01 0.273 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.336730e-01 0.273 0 0
Leishmania phagocytosis R-HSA-9664417 5.356235e-01 0.271 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.356235e-01 0.271 0 0
Parasite infection R-HSA-9664407 5.356235e-01 0.271 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.432466e-01 0.265 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.432466e-01 0.265 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.432466e-01 0.265 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.435216e-01 0.265 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.435216e-01 0.265 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.458172e-01 0.263 0 0
HIV Transcription Initiation R-HSA-167161 5.458172e-01 0.263 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.458172e-01 0.263 0 0
HCMV Late Events R-HSA-9610379 5.498743e-01 0.260 0 0
Iron uptake and transport R-HSA-917937 5.513319e-01 0.259 0 0
Signal amplification R-HSA-392518 5.553456e-01 0.255 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.553456e-01 0.255 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.553456e-01 0.255 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.570231e-01 0.254 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.570231e-01 0.254 0 0
Maturation of nucleoprotein R-HSA-9694631 5.570231e-01 0.254 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.620134e-01 0.250 0 0
Potential therapeutics for SARS R-HSA-9679191 5.642764e-01 0.249 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.675797e-01 0.246 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.675797e-01 0.246 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.675797e-01 0.246 0 0
Interferon gamma signaling R-HSA-877300 5.706140e-01 0.244 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.724105e-01 0.242 0 0
IRS activation R-HSA-74713 5.724105e-01 0.242 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.724105e-01 0.242 0 0
G2 Phase R-HSA-68911 5.724105e-01 0.242 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.724105e-01 0.242 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.724105e-01 0.242 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.724105e-01 0.242 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.724105e-01 0.242 0 0
Activation of C3 and C5 R-HSA-174577 5.724105e-01 0.242 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.724105e-01 0.242 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.724105e-01 0.242 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.724105e-01 0.242 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.724105e-01 0.242 0 0
Co-inhibition by BTLA R-HSA-9927353 5.724105e-01 0.242 0 0
Reelin signalling pathway R-HSA-8866376 5.724105e-01 0.242 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.724105e-01 0.242 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.724105e-01 0.242 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.724105e-01 0.242 0 0
Regulated Necrosis R-HSA-5218859 5.736042e-01 0.241 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.740894e-01 0.241 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.765091e-01 0.239 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.780592e-01 0.238 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.780592e-01 0.238 0 0
Repression of WNT target genes R-HSA-4641265 5.780592e-01 0.238 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.780592e-01 0.238 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.780592e-01 0.238 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.780592e-01 0.238 0 0
Interleukin-35 Signalling R-HSA-8984722 5.780592e-01 0.238 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.780592e-01 0.238 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.780592e-01 0.238 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.811361e-01 0.236 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.844016e-01 0.233 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.844725e-01 0.233 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.844725e-01 0.233 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.844725e-01 0.233 0 0
Creatine metabolism R-HSA-71288 5.844725e-01 0.233 0 0
Inflammasomes R-HSA-622312 5.909172e-01 0.228 0 0
ABC transporter disorders R-HSA-5619084 5.957051e-01 0.225 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.971275e-01 0.224 0 0
GPVI-mediated activation cascade R-HSA-114604 5.971275e-01 0.224 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.981391e-01 0.223 0 0
Amine ligand-binding receptors R-HSA-375280 6.030483e-01 0.220 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.100325e-01 0.215 0 0
G-protein activation R-HSA-202040 6.108109e-01 0.214 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.108109e-01 0.214 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.108109e-01 0.214 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.108109e-01 0.214 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.108109e-01 0.214 0 0
Processing of SMDT1 R-HSA-8949664 6.108845e-01 0.214 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.108845e-01 0.214 0 0
PI Metabolism R-HSA-1483255 6.132330e-01 0.212 0 0
Signaling by Erythropoietin R-HSA-9006335 6.134949e-01 0.212 0 0
mRNA Capping R-HSA-72086 6.134949e-01 0.212 0 0
Glucagon-type ligand receptors R-HSA-420092 6.134949e-01 0.212 0 0
tRNA processing in the nucleus R-HSA-6784531 6.140567e-01 0.212 0 0
Signaling by PDGF R-HSA-186797 6.140567e-01 0.212 0 0
Pyruvate metabolism R-HSA-70268 6.154776e-01 0.211 0 0
Infectious disease R-HSA-5663205 6.188613e-01 0.208 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.206517e-01 0.207 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.212310e-01 0.207 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.212928e-01 0.207 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.212928e-01 0.207 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.212928e-01 0.207 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.212928e-01 0.207 0 0
Signaling by MAPK mutants R-HSA-9652817 6.212928e-01 0.207 0 0
Cam-PDE 1 activation R-HSA-111957 6.212928e-01 0.207 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.212928e-01 0.207 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.212928e-01 0.207 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.212928e-01 0.207 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.212928e-01 0.207 0 0
Signaling by MST1 R-HSA-8852405 6.212928e-01 0.207 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.212928e-01 0.207 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.212928e-01 0.207 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.212928e-01 0.207 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.212928e-01 0.207 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.212928e-01 0.207 0 0
Transmission across Chemical Synapses R-HSA-112315 6.216547e-01 0.206 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.254259e-01 0.204 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.296378e-01 0.201 0 0
DAP12 signaling R-HSA-2424491 6.352824e-01 0.197 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.352824e-01 0.197 0 0
Activation of BH3-only proteins R-HSA-114452 6.352824e-01 0.197 0 0
Interleukin-37 signaling R-HSA-9008059 6.352824e-01 0.197 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.360055e-01 0.197 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.360055e-01 0.197 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.366118e-01 0.196 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.366118e-01 0.196 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.389290e-01 0.195 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.389290e-01 0.195 0 0
Removal of the Flap Intermediate R-HSA-69166 6.417219e-01 0.193 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.417219e-01 0.193 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 6.417219e-01 0.193 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 6.417219e-01 0.193 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 6.417219e-01 0.193 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.417219e-01 0.193 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.417219e-01 0.193 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.417219e-01 0.193 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.417606e-01 0.193 0 0
RSV-host interactions R-HSA-9833110 6.497004e-01 0.187 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.522510e-01 0.186 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.554323e-01 0.183 0 0
Signaling by ALK R-HSA-201556 6.554323e-01 0.183 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.554323e-01 0.183 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.600371e-01 0.180 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.600371e-01 0.180 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.600371e-01 0.180 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.600371e-01 0.180 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.600371e-01 0.180 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.645894e-01 0.177 0 0
STAT5 Activation R-HSA-9645135 6.645894e-01 0.177 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.645894e-01 0.177 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.645894e-01 0.177 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.645894e-01 0.177 0 0
Lactose synthesis R-HSA-5653890 6.645894e-01 0.177 0 0
Abacavir transmembrane transport R-HSA-2161517 6.645894e-01 0.177 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.645894e-01 0.177 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 6.645894e-01 0.177 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.645894e-01 0.177 0 0
HDL clearance R-HSA-8964011 6.645894e-01 0.177 0 0
MET Receptor Activation R-HSA-6806942 6.645894e-01 0.177 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.645894e-01 0.177 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.645894e-01 0.177 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.705969e-01 0.174 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.705969e-01 0.174 0 0
p38MAPK events R-HSA-171007 6.705969e-01 0.174 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.705969e-01 0.174 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.705969e-01 0.174 0 0
Signaling by Activin R-HSA-1502540 6.705969e-01 0.174 0 0
DNA Damage Reversal R-HSA-73942 6.705969e-01 0.174 0 0
Adaptive Immune System R-HSA-1280218 6.706983e-01 0.173 0 0
Interleukin-1 family signaling R-HSA-446652 6.709332e-01 0.173 0 0
Intraflagellar transport R-HSA-5620924 6.728048e-01 0.172 0 0
GPER1 signaling R-HSA-9634597 6.728048e-01 0.172 0 0
NGF-stimulated transcription R-HSA-9031628 6.728048e-01 0.172 0 0
Platelet homeostasis R-HSA-418346 6.729613e-01 0.172 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.730227e-01 0.172 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.736162e-01 0.172 0 0
Diseases of Immune System R-HSA-5260271 6.736162e-01 0.172 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.757893e-01 0.170 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.764039e-01 0.170 0 0
IRE1alpha activates chaperones R-HSA-381070 6.797094e-01 0.168 0 0
FOXO-mediated transcription R-HSA-9614085 6.819330e-01 0.166 0 0
Leishmania infection R-HSA-9658195 6.861573e-01 0.164 0 0
Parasitic Infection Pathways R-HSA-9824443 6.861573e-01 0.164 0 0
MHC class II antigen presentation R-HSA-2132295 6.890833e-01 0.162 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.975550e-01 0.156 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.975550e-01 0.156 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.975550e-01 0.156 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.975550e-01 0.156 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.975550e-01 0.156 0 0
Translation of Structural Proteins R-HSA-9694635 7.020746e-01 0.154 0 0
Extension of Telomeres R-HSA-180786 7.027735e-01 0.153 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.029383e-01 0.153 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.029383e-01 0.153 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.029383e-01 0.153 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.029383e-01 0.153 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.029383e-01 0.153 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.029383e-01 0.153 0 0
PTK6 Expression R-HSA-8849473 7.029383e-01 0.153 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.029383e-01 0.153 0 0
Disinhibition of SNARE formation R-HSA-114516 7.029383e-01 0.153 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.029383e-01 0.153 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.029383e-01 0.153 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.029383e-01 0.153 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.029383e-01 0.153 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.029383e-01 0.153 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.045934e-01 0.152 0 0
Complex III assembly R-HSA-9865881 7.045934e-01 0.152 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.045934e-01 0.152 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.080338e-01 0.150 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.141846e-01 0.146 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.141846e-01 0.146 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.141846e-01 0.146 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.146443e-01 0.146 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.146443e-01 0.146 0 0
PCP/CE pathway R-HSA-4086400 7.147043e-01 0.146 0 0
Toll-like Receptor Cascades R-HSA-168898 7.168397e-01 0.145 0 0
RAB geranylgeranylation R-HSA-8873719 7.169005e-01 0.145 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.222699e-01 0.141 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.226570e-01 0.141 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 7.226570e-01 0.141 0 0
Galactose catabolism R-HSA-70370 7.226570e-01 0.141 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.226570e-01 0.141 0 0
Response to metal ions R-HSA-5660526 7.226570e-01 0.141 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.242573e-01 0.140 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.251334e-01 0.140 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.251334e-01 0.140 0 0
G protein gated Potassium channels R-HSA-1296059 7.251334e-01 0.140 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.251334e-01 0.140 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.251334e-01 0.140 0 0
Immune System R-HSA-168256 7.317675e-01 0.136 0 0
Gap junction assembly R-HSA-190861 7.318179e-01 0.136 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.369046e-01 0.133 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.369046e-01 0.133 0 0
Activation of RAS in B cells R-HSA-1169092 7.369046e-01 0.133 0 0
Fructose biosynthesis R-HSA-5652227 7.369046e-01 0.133 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.369046e-01 0.133 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.369046e-01 0.133 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.369046e-01 0.133 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.369046e-01 0.133 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.369046e-01 0.133 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.369046e-01 0.133 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.369046e-01 0.133 0 0
Inositol phosphate metabolism R-HSA-1483249 7.372021e-01 0.132 0 0
MET activates PTK2 signaling R-HSA-8874081 7.445382e-01 0.128 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.445382e-01 0.128 0 0
TRP channels R-HSA-3295583 7.445382e-01 0.128 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.445382e-01 0.128 0 0
Urea cycle R-HSA-70635 7.445382e-01 0.128 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.445382e-01 0.128 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.459749e-01 0.127 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.459749e-01 0.127 0 0
Sulfide oxidation to sulfate R-HSA-1614517 7.459749e-01 0.127 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.459749e-01 0.127 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.628335e-01 0.118 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.628335e-01 0.118 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.669889e-01 0.115 0 0
Interleukin-21 signaling R-HSA-9020958 7.669889e-01 0.115 0 0
WNT mediated activation of DVL R-HSA-201688 7.669889e-01 0.115 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.669889e-01 0.115 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.669889e-01 0.115 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.669889e-01 0.115 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.669889e-01 0.115 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.669889e-01 0.115 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.669889e-01 0.115 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.675884e-01 0.115 0 0
PKA activation R-HSA-163615 7.675884e-01 0.115 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.689954e-01 0.114 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.689954e-01 0.114 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.725049e-01 0.112 0 0
Neuronal System R-HSA-112316 7.767421e-01 0.110 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.800498e-01 0.108 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.800498e-01 0.108 0 0
Cardiac conduction R-HSA-5576891 7.822867e-01 0.107 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.875824e-01 0.104 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.875824e-01 0.104 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.875824e-01 0.104 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.875824e-01 0.104 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.875824e-01 0.104 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.898499e-01 0.102 0 0
DNA replication initiation R-HSA-68952 7.936346e-01 0.100 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.936346e-01 0.100 0 0
PI3K/AKT activation R-HSA-198203 7.936346e-01 0.100 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.936346e-01 0.100 0 0
Maturation of spike protein R-HSA-9683686 7.936346e-01 0.100 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.941782e-01 0.100 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.962219e-01 0.099 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.060445e-01 0.094 0 0
Protein hydroxylation R-HSA-9629569 8.060445e-01 0.094 0 0
Signaling by NODAL R-HSA-1181150 8.060445e-01 0.094 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.078042e-01 0.093 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.101229e-01 0.091 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.113875e-01 0.091 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.113875e-01 0.091 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.113875e-01 0.091 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.172348e-01 0.088 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.172348e-01 0.088 0 0
vRNP Assembly R-HSA-192905 8.172348e-01 0.088 0 0
vRNA Synthesis R-HSA-192814 8.172348e-01 0.088 0 0
Propionyl-CoA catabolism R-HSA-71032 8.172348e-01 0.088 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.172348e-01 0.088 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.172348e-01 0.088 0 0
LGI-ADAM interactions R-HSA-5682910 8.172348e-01 0.088 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.172348e-01 0.088 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.172348e-01 0.088 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.172348e-01 0.088 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.172348e-01 0.088 0 0
Interleukin-2 family signaling R-HSA-451927 8.206853e-01 0.086 0 0
Signalling to RAS R-HSA-167044 8.230635e-01 0.085 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.255864e-01 0.083 0 0
Cargo concentration in the ER R-HSA-5694530 8.255864e-01 0.083 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.263640e-01 0.083 0 0
Hemostasis R-HSA-109582 8.294522e-01 0.081 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.381372e-01 0.077 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.381372e-01 0.077 0 0
Plasmalogen biosynthesis R-HSA-75896 8.381372e-01 0.077 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.381372e-01 0.077 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.381372e-01 0.077 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.381372e-01 0.077 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.381372e-01 0.077 0 0
Sodium/Calcium exchangers R-HSA-425561 8.381372e-01 0.077 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.381372e-01 0.077 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.381372e-01 0.077 0 0
Attachment and Entry R-HSA-9694614 8.387281e-01 0.076 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.387281e-01 0.076 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.387281e-01 0.076 0 0
Serine metabolism R-HSA-977347 8.387281e-01 0.076 0 0
Ribavirin ADME R-HSA-9755088 8.387281e-01 0.076 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.388603e-01 0.076 0 0
Disease R-HSA-1643685 8.404178e-01 0.076 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.443094e-01 0.073 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.503332e-01 0.070 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.531252e-01 0.069 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.531252e-01 0.069 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.531252e-01 0.069 0 0
Fructose metabolism R-HSA-5652084 8.531252e-01 0.069 0 0
Ethanol oxidation R-HSA-71384 8.531252e-01 0.069 0 0
Cellular hexose transport R-HSA-189200 8.531252e-01 0.069 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.566501e-01 0.067 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.566501e-01 0.067 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.566501e-01 0.067 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.566501e-01 0.067 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.566501e-01 0.067 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.566501e-01 0.067 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.566501e-01 0.067 0 0
MET activates RAS signaling R-HSA-8851805 8.566501e-01 0.067 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.566501e-01 0.067 0 0
Synthesis of GDP-mannose R-HSA-446205 8.566501e-01 0.067 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.566501e-01 0.067 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.566501e-01 0.067 0 0
Heme degradation R-HSA-189483 8.628036e-01 0.064 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.628036e-01 0.064 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.663400e-01 0.062 0 0
Interleukin-20 family signaling R-HSA-8854691 8.663400e-01 0.062 0 0
Insulin receptor signalling cascade R-HSA-74751 8.679332e-01 0.062 0 0
Formation of axial mesoderm R-HSA-9796292 8.730466e-01 0.059 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.730466e-01 0.059 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.735589e-01 0.059 0 0
DAP12 interactions R-HSA-2172127 8.747878e-01 0.058 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.784543e-01 0.056 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.784543e-01 0.056 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.784543e-01 0.056 0 0
G alpha (z) signalling events R-HSA-418597 8.786218e-01 0.056 0 0
Developmental Cell Lineages R-HSA-9734767 8.831365e-01 0.054 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.835603e-01 0.054 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.835603e-01 0.054 0 0
Integration of energy metabolism R-HSA-163685 8.851519e-01 0.053 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.875685e-01 0.052 0 0
Transport of fatty acids R-HSA-804914 8.875685e-01 0.052 0 0
Hydrolysis of LPC R-HSA-1483115 8.875685e-01 0.052 0 0
Prolactin receptor signaling R-HSA-1170546 8.875685e-01 0.052 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.875685e-01 0.052 0 0
Ciprofloxacin ADME R-HSA-9793528 8.875685e-01 0.052 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.875685e-01 0.052 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.895471e-01 0.051 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.895471e-01 0.051 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.895471e-01 0.051 0 0
Laminin interactions R-HSA-3000157 8.895471e-01 0.051 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.895471e-01 0.051 0 0
PPARA activates gene expression R-HSA-1989781 8.899064e-01 0.051 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.928497e-01 0.049 0 0
RNA Polymerase III Transcription R-HSA-74158 8.928497e-01 0.049 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.996934e-01 0.046 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.004300e-01 0.046 0 0
Protein lipoylation R-HSA-9857492 9.004300e-01 0.046 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 9.004300e-01 0.046 0 0
Biotin transport and metabolism R-HSA-196780 9.004300e-01 0.046 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.004300e-01 0.046 0 0
Transport and metabolism of PAPS R-HSA-174362 9.004300e-01 0.046 0 0
Other semaphorin interactions R-HSA-416700 9.004300e-01 0.046 0 0
Voltage gated Potassium channels R-HSA-1296072 9.014683e-01 0.045 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.041714e-01 0.044 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.080355e-01 0.042 0 0
Signaling by BMP R-HSA-201451 9.089646e-01 0.041 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.089646e-01 0.041 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.089646e-01 0.041 0 0
Insulin processing R-HSA-264876 9.089646e-01 0.041 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.089646e-01 0.041 0 0
MET promotes cell motility R-HSA-8875878 9.094560e-01 0.041 0 0
COPII-mediated vesicle transport R-HSA-204005 9.102905e-01 0.041 0 0
Regulation of insulin secretion R-HSA-422356 9.108982e-01 0.041 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.118209e-01 0.040 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.118209e-01 0.040 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.118209e-01 0.040 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.118209e-01 0.040 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.118209e-01 0.040 0 0
Fructose catabolism R-HSA-70350 9.118209e-01 0.040 0 0
Differentiation of T cells R-HSA-9945266 9.118209e-01 0.040 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.118209e-01 0.040 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.118209e-01 0.040 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.118209e-01 0.040 0 0
Killing mechanisms R-HSA-9664420 9.118209e-01 0.040 0 0
Attachment and Entry R-HSA-9678110 9.118209e-01 0.040 0 0
Atorvastatin ADME R-HSA-9754706 9.118209e-01 0.040 0 0
Virus Assembly and Release R-HSA-168268 9.118209e-01 0.040 0 0
Pentose phosphate pathway R-HSA-71336 9.168513e-01 0.038 0 0
Telomere Extension By Telomerase R-HSA-171319 9.174281e-01 0.037 0 0
Pyroptosis R-HSA-5620971 9.174281e-01 0.037 0 0
Aquaporin-mediated transport R-HSA-445717 9.202538e-01 0.036 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.205623e-01 0.036 0 0
Azathioprine ADME R-HSA-9748787 9.205623e-01 0.036 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.215182e-01 0.035 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.219093e-01 0.035 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.219093e-01 0.035 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.219093e-01 0.035 0 0
Glycine degradation R-HSA-6783984 9.219093e-01 0.035 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.219093e-01 0.035 0 0
Fibronectin matrix formation R-HSA-1566977 9.219093e-01 0.035 0 0
Heme assimilation R-HSA-9927020 9.219093e-01 0.035 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.219093e-01 0.035 0 0
Phase 2 - plateau phase R-HSA-5576893 9.219093e-01 0.035 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.219093e-01 0.035 0 0
Passive transport by Aquaporins R-HSA-432047 9.219093e-01 0.035 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.219093e-01 0.035 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.219093e-01 0.035 0 0
Innate Immune System R-HSA-168249 9.229849e-01 0.035 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.236917e-01 0.034 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.251472e-01 0.034 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.266559e-01 0.033 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.280950e-01 0.032 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.300127e-01 0.032 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.307395e-01 0.031 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.308440e-01 0.031 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.308440e-01 0.031 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.308440e-01 0.031 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.308440e-01 0.031 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.308440e-01 0.031 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.308440e-01 0.031 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.321816e-01 0.030 0 0
Neurotransmitter clearance R-HSA-112311 9.321816e-01 0.030 0 0
Mitochondrial protein degradation R-HSA-9837999 9.348944e-01 0.029 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.358487e-01 0.029 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.385867e-01 0.028 0 0
PKA activation in glucagon signalling R-HSA-164378 9.387569e-01 0.027 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.387569e-01 0.027 0 0
Activation of GABAB receptors R-HSA-991365 9.412322e-01 0.026 0 0
GABA B receptor activation R-HSA-977444 9.412322e-01 0.026 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.457648e-01 0.024 0 0
Specification of the neural plate border R-HSA-9834899 9.457648e-01 0.024 0 0
Amino Acid conjugation R-HSA-156587 9.457648e-01 0.024 0 0
Conjugation of carboxylic acids R-HSA-159424 9.457648e-01 0.024 0 0
Diseases of hemostasis R-HSA-9671793 9.457648e-01 0.024 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.457648e-01 0.024 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.457648e-01 0.024 0 0
Potassium Channels R-HSA-1296071 9.460776e-01 0.024 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.487217e-01 0.023 0 0
Recycling of bile acids and salts R-HSA-159418 9.497132e-01 0.022 0 0
Cardiogenesis R-HSA-9733709 9.497132e-01 0.022 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.497132e-01 0.022 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.519712e-01 0.021 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.519712e-01 0.021 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.519712e-01 0.021 0 0
Formation of definitive endoderm R-HSA-9823730 9.519712e-01 0.021 0 0
Pregnenolone biosynthesis R-HSA-196108 9.519712e-01 0.021 0 0
Metabolism of proteins R-HSA-392499 9.535245e-01 0.021 0 0
Neddylation R-HSA-8951664 9.543941e-01 0.020 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.545275e-01 0.020 0 0
IRS-mediated signalling R-HSA-112399 9.545820e-01 0.020 0 0
Dectin-2 family R-HSA-5621480 9.545820e-01 0.020 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.549698e-01 0.020 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.574676e-01 0.019 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.574676e-01 0.019 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.574676e-01 0.019 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.574676e-01 0.019 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.574676e-01 0.019 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.574676e-01 0.019 0 0
eNOS activation R-HSA-203615 9.588988e-01 0.018 0 0
RA biosynthesis pathway R-HSA-5365859 9.588988e-01 0.018 0 0
Regulation of beta-cell development R-HSA-186712 9.614761e-01 0.017 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.623354e-01 0.017 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.623913e-01 0.017 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.628656e-01 0.016 0 0
Signaling by Insulin receptor R-HSA-74752 9.633511e-01 0.016 0 0
Metabolism of polyamines R-HSA-351202 9.645467e-01 0.016 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.647381e-01 0.016 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.659689e-01 0.015 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.664630e-01 0.015 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.666463e-01 0.015 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.666463e-01 0.015 0 0
LDL clearance R-HSA-8964038 9.666463e-01 0.015 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.673885e-01 0.014 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.697237e-01 0.013 0 0
Metabolism of folate and pterines R-HSA-196757 9.697237e-01 0.013 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.704640e-01 0.013 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.704640e-01 0.013 0 0
Formation of the ureteric bud R-HSA-9830674 9.704640e-01 0.013 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.704640e-01 0.013 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.704640e-01 0.013 0 0
Formation of the cornified envelope R-HSA-6809371 9.707228e-01 0.013 0 0
PI3K Cascade R-HSA-109704 9.713973e-01 0.013 0 0
Elastic fibre formation R-HSA-1566948 9.726776e-01 0.012 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.726776e-01 0.012 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.734334e-01 0.012 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.734334e-01 0.012 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.738449e-01 0.012 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.738449e-01 0.012 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.738449e-01 0.012 0 0
IGF1R signaling cascade R-HSA-2428924 9.746894e-01 0.011 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.757740e-01 0.011 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.767607e-01 0.010 0 0
Hyaluronan degradation R-HSA-2160916 9.768390e-01 0.010 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.768390e-01 0.010 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.768390e-01 0.010 0 0
Formation of the nephric duct R-HSA-9830364 9.768390e-01 0.010 0 0
Tryptophan catabolism R-HSA-71240 9.777727e-01 0.010 0 0
Nucleotide biosynthesis R-HSA-8956320 9.783332e-01 0.010 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.788963e-01 0.009 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.794905e-01 0.009 0 0
Sphingolipid catabolism R-HSA-9845614 9.794905e-01 0.009 0 0
Abacavir ADME R-HSA-2161522 9.794905e-01 0.009 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.794905e-01 0.009 0 0
Maturation of spike protein R-HSA-9694548 9.799622e-01 0.009 0 0
Nicotinate metabolism R-HSA-196807 9.804339e-01 0.009 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.818386e-01 0.008 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.818386e-01 0.008 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.819419e-01 0.008 0 0
Paracetamol ADME R-HSA-9753281 9.820323e-01 0.008 0 0
Insulin receptor recycling R-HSA-77387 9.839180e-01 0.007 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.842059e-01 0.007 0 0
FCGR activation R-HSA-2029481 9.853890e-01 0.006 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.857594e-01 0.006 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.857594e-01 0.006 0 0
Methylation R-HSA-156581 9.868070e-01 0.006 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.876998e-01 0.005 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.881246e-01 0.005 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.881246e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.882830e-01 0.005 0 0
GABA receptor activation R-HSA-977443 9.888217e-01 0.005 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.888341e-01 0.005 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.897266e-01 0.004 0 0
HS-GAG degradation R-HSA-2024096 9.901128e-01 0.004 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.903227e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.903860e-01 0.004 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.920580e-01 0.003 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.922247e-01 0.003 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.922479e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.925976e-01 0.003 0 0
Integrin cell surface interactions R-HSA-216083 9.926124e-01 0.003 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.931358e-01 0.003 0 0
Hyaluronan metabolism R-HSA-2142845 9.931358e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.937179e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.937454e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.939221e-01 0.003 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.939221e-01 0.003 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.939221e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.939221e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.946184e-01 0.002 0 0
Triglyceride catabolism R-HSA-163560 9.946184e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.946184e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.948217e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.949290e-01 0.002 0 0
NCAM1 interactions R-HSA-419037 9.952349e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.952349e-01 0.002 0 0
tRNA processing R-HSA-72306 9.955842e-01 0.002 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.957808e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.957808e-01 0.002 0 0
Gastrulation R-HSA-9758941 9.958655e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.961762e-01 0.002 0 0
Metabolism of porphyrins R-HSA-189445 9.961762e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.961762e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.962642e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.963067e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.966923e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.966923e-01 0.001 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.967690e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.968653e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.973685e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.974069e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.976192e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.976192e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.977041e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.977794e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.979158e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.979672e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.979672e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.985892e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.986184e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.987174e-01 0.001 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.987445e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.987509e-01 0.001 0 0
Kidney development R-HSA-9830369 9.988920e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.988920e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.989668e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.990209e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.990375e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.990387e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.991332e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.992036e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.992244e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.992325e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.992325e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.992401e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.992618e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.992825e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.992868e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.992868e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.994882e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.994963e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.995419e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.996305e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996718e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.996718e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.997104e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.997104e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.997421e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997651e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.997730e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.997730e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998060e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998221e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998425e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.998469e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998497e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998812e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998908e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999033e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.999033e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999174e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999329e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999353e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999535e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999554e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999604e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999633e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999690e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999690e-01 0.000 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.999714e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999714e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999747e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999747e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999753e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999830e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999860e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999885e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999913e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999937e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999939e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999965e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999970e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999971e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999975e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999983e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999989e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999992e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999993e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999995e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999996e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999997e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999997e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999998e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways