SRPK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07814 S886 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAKVLFD
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P10636 S214 PSP MAPT MAPTL MTBT1 TAU GDLHQEGPPLKGAGGKERPGsKEEVDEDRDVDESsPQDsPP
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 S603 Sugiyama FXR2 FMR1L2 QRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsR
P61978 S284 Sugiyama HNRNPK HNRPK MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P67809 Y208 Sugiyama YBX1 NSEP1 YB1 yRRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGE
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78362 S114 Sugiyama SRPK2 TVWLCWDMQGKRFVAMKVVKsAQHyTETALDEIKLLKCVRE
P78362 S248 Sugiyama SRPK2 YVRRMAAEATEWQKAGAPPPsGsAVsTAPQQKPIGKISKNK
P78362 S253 Sugiyama SRPK2 AAEATEWQKAGAPPPsGsAVsTAPQQKPIGKISKNKKKKLK
P78362 S380 Sugiyama SRPK2 EKDEDDVDQELANIDPtWIEsPKTNGHIENGPFSLEQQLDD
P78362 S494 PSP SRPK2 GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN
P78362 T307 Sugiyama SRPK2 LQEIEELEREAERKIIEENItSAAPsNDQDGEYCPEVKLKT
P78362 T328 Sugiyama SRPK2 SAAPsNDQDGEYCPEVKLKTtGLEEAAEAETAKDNGEAEDQ
P78362 T547 Sugiyama SRPK2 KIADLGNACWVHKHFTEDIQtRQYRSIEVLIGAGYSTPADI
P78362 Y118 Sugiyama SRPK2 CWDMQGKRFVAMKVVKsAQHyTETALDEIKLLKCVRESDPS
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8NAF0 S455 Sugiyama ZNF579 AGGPAPHPCPRCPRRFSRAYsLLRHQRCHRAELERAAALQA
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96MU7 S308 Sugiyama YTHDC1 KIAA1966 YT521 GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q96SB4 T514 Sugiyama SRPK1 KIADLGNACWVHKHFTEDIQtRQYRSLEVLIGSGYNTPADI
Q96T37 S670 Sugiyama RBM15 OTT OTT1 GRHLDRsPEsDRPRKRHCAPsPDRsPELsssRDRYNsDNDR
Q99538 S226 SIGNOR|EPSD|PSP LGMN PRSC1 ATTAANPRESSYACYYDEKRsTYLGDWYSVNWMEDSDVEDL
Q9NY27 S311 Sugiyama PPP4R2 SBBI57 CTRQHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDD
Q9NY27 S315 Sugiyama PPP4R2 SBBI57 HCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALTV
Q9NY27 T297 Sugiyama PPP4R2 SBBI57 EAssssQDKDKDSRCTRQHCtEEDEEEDEEEEEEsFMtsRE
Q9NY27 T314 Sugiyama PPP4R2 SBBI57 QHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALT
Q9NYV4 S249 Sugiyama CDK12 CRK7 CRKRS KIAA0904 DSSKQDDsPsGAsYGQDyDLsPsRsHtssNYDsYKKsPGsT
Q9UKV3 S1180 GPS6|SIGNOR|EPSD|PSP ACIN1 ACINUS KIAA0670 RsEREWDRDKVREGPRSRSRsRDRRRKERAKSKEKKSEKKE
Q9UQ35 S1101 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEF
Q9UQ35 S1102 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 EsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFs
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35 S2694 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 RSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQSSs
Q9UQ35 S876 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9UQ35 T328 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.694797e-07 6.771 0 0
mRNA 3'-end processing R-HSA-72187 3.995781e-07 6.398 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.434905e-07 6.191 0 0
RNA Polymerase II Transcription R-HSA-73857 9.119706e-07 6.040 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.092670e-06 5.962 0 0
Gene expression (Transcription) R-HSA-74160 1.528832e-06 5.816 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.995671e-06 5.524 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.672420e-06 5.330 0 0
mRNA Splicing R-HSA-72172 8.054400e-06 5.094 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.090312e-05 4.962 0 0
Chromatin organization R-HSA-4839726 4.256918e-05 4.371 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.148500e-05 4.146 0 0
Chromatin modifying enzymes R-HSA-3247509 7.883466e-05 4.103 0 0
Generic Transcription Pathway R-HSA-212436 9.517452e-05 4.021 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.229084e-04 3.652 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.273717e-04 3.643 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.521338e-04 3.453 0 0
NRAGE signals death through JNK R-HSA-193648 3.748478e-04 3.426 0 0
Apoptotic execution phase R-HSA-75153 5.150418e-04 3.288 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.608690e-04 3.180 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.369144e-04 3.196 0 0
Cell Cycle R-HSA-1640170 6.757602e-04 3.170 0 0
Regulation of TP53 Activity R-HSA-5633007 8.228474e-04 3.085 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 9.917373e-04 3.004 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.230603e-03 2.910 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.469005e-03 2.833 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.536873e-03 2.813 0 0
Cell Cycle, Mitotic R-HSA-69278 1.554087e-03 2.809 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.969953e-03 2.706 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.142232e-03 2.669 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.284543e-03 2.641 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.421048e-03 2.466 0 0
G alpha (12/13) signalling events R-HSA-416482 3.500800e-03 2.456 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.750352e-03 2.426 0 0
Neurexins and neuroligins R-HSA-6794361 3.750352e-03 2.426 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.556423e-03 2.449 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.319683e-03 2.365 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.338764e-03 2.363 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.560518e-03 2.341 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.817796e-03 2.317 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.817796e-03 2.317 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.863980e-03 2.232 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.107827e-03 2.148 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.107827e-03 2.148 0 0
Nuclear RNA decay R-HSA-9930044 7.093708e-03 2.149 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.170603e-03 2.144 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.623641e-03 2.118 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.014503e-03 2.096 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.907958e-03 2.102 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.184725e-03 2.087 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.348161e-03 2.078 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.371750e-03 2.077 0 0
HIV elongation arrest and recovery R-HSA-167287 8.526320e-03 2.069 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.526320e-03 2.069 0 0
HIV Transcription Elongation R-HSA-167169 9.297061e-03 2.032 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.297061e-03 2.032 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.297061e-03 2.032 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.297061e-03 2.032 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.242011e-03 2.034 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.487896e-03 2.023 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.061571e-02 1.974 0 0
Mitotic Prometaphase R-HSA-68877 1.088797e-02 1.963 0 0
Deadenylation of mRNA R-HSA-429947 1.221762e-02 1.913 0 0
Transcription of the HIV genome R-HSA-167172 1.182399e-02 1.927 0 0
Centrosome maturation R-HSA-380287 1.170194e-02 1.932 0 0
Specification of the neural plate border R-HSA-9834899 1.188026e-02 1.925 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.145076e-02 1.941 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.201474e-02 1.920 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.351843e-02 1.869 0 0
Formation of the anterior neural plate R-HSA-9823739 1.351843e-02 1.869 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.351843e-02 1.869 0 0
HIV Life Cycle R-HSA-162587 1.296433e-02 1.887 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.360176e-02 1.866 0 0
Formation of the posterior neural plate R-HSA-9832991 1.454362e-02 1.837 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.453404e-02 1.838 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.676304e-02 1.776 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.676304e-02 1.776 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.607422e-02 1.794 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.680996e-02 1.774 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.642183e-02 1.785 0 0
Cardiogenesis R-HSA-9733709 1.903591e-02 1.720 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.903591e-02 1.720 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.902184e-02 1.721 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.845280e-02 1.734 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.903591e-02 1.720 0 0
Metabolism of RNA R-HSA-8953854 1.817397e-02 1.741 0 0
Signal Transduction R-HSA-162582 1.983812e-02 1.702 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.985955e-02 1.702 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.008067e-02 1.697 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.008067e-02 1.697 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.090106e-02 1.680 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.098767e-02 1.678 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.106193e-02 1.677 0 0
M Phase R-HSA-68886 2.328676e-02 1.633 0 0
Regulation of gap junction activity R-HSA-191650 2.344791e-02 1.630 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.415105e-02 1.617 0 0
Type I hemidesmosome assembly R-HSA-446107 2.618559e-02 1.582 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.465491e-02 1.608 0 0
Nuclear import of Rev protein R-HSA-180746 2.514614e-02 1.600 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.451267e-02 1.611 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.584384e-02 1.588 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.618559e-02 1.582 0 0
Mitotic Anaphase R-HSA-68882 2.668014e-02 1.574 0 0
Cell Cycle Checkpoints R-HSA-69620 2.677676e-02 1.572 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.693393e-02 1.570 0 0
Heme signaling R-HSA-9707616 2.783511e-02 1.555 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.807300e-02 1.552 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.903770e-02 1.537 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.155624e-02 1.501 0 0
Polo-like kinase mediated events R-HSA-156711 3.062192e-02 1.514 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.019242e-02 1.520 0 0
G2/M Transition R-HSA-69275 2.991073e-02 1.524 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.327548e-02 1.478 0 0
HATs acetylate histones R-HSA-3214847 3.329305e-02 1.478 0 0
Signaling by NTRKs R-HSA-166520 3.351150e-02 1.475 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.643173e-02 1.439 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.643173e-02 1.439 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.428513e-02 1.465 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.673549e-02 1.435 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.525399e-02 1.453 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.626776e-02 1.440 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.488265e-02 1.457 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.710613e-02 1.431 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.732426e-02 1.428 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.174004e-02 1.379 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.290373e-02 1.368 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.290373e-02 1.368 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.290373e-02 1.368 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.290373e-02 1.368 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.213411e-02 1.375 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.562985e-02 1.341 0 0
DNA Double Strand Break Response R-HSA-5693606 4.395060e-02 1.357 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.427871e-02 1.354 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.381202e-02 1.358 0 0
Signaling by ALK R-HSA-201556 4.622517e-02 1.335 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.622517e-02 1.335 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.622517e-02 1.335 0 0
Death Receptor Signaling R-HSA-73887 4.704569e-02 1.327 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 4.807498e-02 1.318 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.983279e-02 1.302 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.005552e-02 1.301 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.031391e-02 1.298 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.152993e-02 1.288 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.152993e-02 1.288 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.210666e-02 1.283 0 0
FOXO-mediated transcription R-HSA-9614085 5.775345e-02 1.238 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.866876e-02 1.232 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.866876e-02 1.232 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.487881e-02 1.261 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.775345e-02 1.238 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.913298e-02 1.228 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.913298e-02 1.228 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.217917e-02 1.206 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.217917e-02 1.206 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.217917e-02 1.206 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.217917e-02 1.206 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.217917e-02 1.206 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.217917e-02 1.206 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.669364e-02 1.176 0 0
Activation of RAC1 R-HSA-428540 6.669364e-02 1.176 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.964738e-02 1.224 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.964738e-02 1.224 0 0
Regulation of TP53 Expression R-HSA-6804754 6.217917e-02 1.206 0 0
Disorders of Developmental Biology R-HSA-9675151 6.326494e-02 1.199 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.671475e-02 1.176 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.987483e-02 1.156 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.088012e-02 1.149 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.098505e-02 1.149 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 8.135559e-02 1.090 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.135559e-02 1.090 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.380377e-02 1.132 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.485470e-02 1.126 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.557308e-02 1.122 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.451462e-02 1.128 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.485470e-02 1.126 0 0
Homology Directed Repair R-HSA-5693538 8.067765e-02 1.093 0 0
Signaling by Hippo R-HSA-2028269 7.380377e-02 1.132 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.069009e-02 1.093 0 0
Specification of primordial germ cells R-HSA-9827857 7.380377e-02 1.132 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.005139e-02 1.097 0 0
Disorders of Nervous System Development R-HSA-9697154 8.005139e-02 1.097 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.005139e-02 1.097 0 0
Pervasive developmental disorders R-HSA-9005895 8.005139e-02 1.097 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.005139e-02 1.097 0 0
RUNX2 regulates bone development R-HSA-8941326 7.267672e-02 1.139 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.159886e-02 1.088 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.355236e-02 1.078 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.355236e-02 1.078 0 0
Ephrin signaling R-HSA-3928664 8.523628e-02 1.069 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.523628e-02 1.069 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.685020e-02 1.061 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.787295e-02 1.056 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.571029e-02 1.019 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 9.109530e-02 1.041 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.008599e-01 0.996 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.008599e-01 0.996 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.615517e-02 1.017 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.026034e-01 0.989 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.348028e-02 1.029 0 0
Nucleotide Excision Repair R-HSA-5696398 8.853278e-02 1.053 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.754057e-02 1.011 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.008599e-01 0.996 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.615517e-02 1.017 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.462966e-02 1.024 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.026034e-01 0.989 0 0
Frs2-mediated activation R-HSA-170968 9.462452e-02 1.024 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.026034e-01 0.989 0 0
Deubiquitination R-HSA-5688426 9.814810e-02 1.008 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 9.462452e-02 1.024 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.854654e-02 1.053 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.020595e-01 0.991 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.026034e-01 0.989 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.008599e-01 0.996 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.854654e-02 1.053 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.047385e-01 0.980 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.062672e-01 0.974 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.074129e-01 0.969 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.822652e-01 0.739 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.822652e-01 0.739 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 1.822652e-01 0.739 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.230685e-01 0.910 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.230685e-01 0.910 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.230685e-01 0.910 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.230685e-01 0.910 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.230685e-01 0.910 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.230685e-01 0.910 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.605401e-01 0.584 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.605401e-01 0.584 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.605401e-01 0.584 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.605401e-01 0.584 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.605401e-01 0.584 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.605401e-01 0.584 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.605401e-01 0.584 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.605401e-01 0.584 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.605401e-01 0.584 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.605401e-01 0.584 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.572496e-01 0.803 0 0
IRS activation R-HSA-74713 1.572496e-01 0.803 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.572496e-01 0.803 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.929237e-01 0.715 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 1.929237e-01 0.715 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.929237e-01 0.715 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.313266e-01 0.480 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.313266e-01 0.480 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.313266e-01 0.480 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.313266e-01 0.480 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.313266e-01 0.480 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.313266e-01 0.480 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.446300e-01 0.840 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.446300e-01 0.840 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.103491e-01 0.957 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.294923e-01 0.639 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.684815e-01 0.773 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.684815e-01 0.773 0 0
Translesion synthesis by REV1 R-HSA-110312 1.271505e-01 0.896 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.271505e-01 0.896 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.449455e-01 0.839 0 0
Differentiation of T cells R-HSA-9945266 1.449455e-01 0.839 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.449455e-01 0.839 0 0
Translesion synthesis by POLI R-HSA-5656121 1.449455e-01 0.839 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.449455e-01 0.839 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.933671e-01 0.714 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.933671e-01 0.714 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.664578e-01 0.574 0 0
PTK6 Expression R-HSA-8849473 2.664578e-01 0.574 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.664578e-01 0.574 0 0
SOS-mediated signalling R-HSA-112412 2.664578e-01 0.574 0 0
DAG1 core M1 glycosylations R-HSA-8932506 2.664578e-01 0.574 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.953406e-01 0.403 0 0
MET activates PTPN11 R-HSA-8865999 3.953406e-01 0.403 0 0
Invadopodia formation R-HSA-8941237 3.953406e-01 0.403 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.953406e-01 0.403 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.953406e-01 0.403 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 3.953406e-01 0.403 0 0
Translesion synthesis by POLK R-HSA-5655862 1.636445e-01 0.786 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.190849e-01 0.659 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.190849e-01 0.659 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.831534e-01 0.737 0 0
DAG1 core M2 glycosylations R-HSA-8932504 3.034095e-01 0.518 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.034095e-01 0.518 0 0
MET receptor recycling R-HSA-8875656 3.034095e-01 0.518 0 0
Formation of annular gap junctions R-HSA-196025 3.034095e-01 0.518 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.034095e-01 0.518 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.454419e-01 0.610 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.129404e-01 0.947 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.033754e-01 0.692 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.449708e-01 0.839 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.158090e-01 0.936 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.351760e-01 0.869 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.586654e-01 0.800 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.876275e-01 0.727 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.400116e-01 0.469 0 0
Gap junction degradation R-HSA-190873 3.400116e-01 0.469 0 0
ALK mutants bind TKIs R-HSA-9700645 3.400116e-01 0.469 0 0
MTF1 activates gene expression R-HSA-5660489 4.532298e-01 0.344 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.532298e-01 0.344 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.532298e-01 0.344 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.532298e-01 0.344 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.532298e-01 0.344 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.532298e-01 0.344 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.455669e-01 0.610 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.876300e-01 0.727 0 0
Erythropoietin activates RAS R-HSA-9027284 2.993562e-01 0.524 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 2.673421e-01 0.573 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.673421e-01 0.573 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.759927e-01 0.425 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.894440e-01 0.538 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.894440e-01 0.538 0 0
Dual Incision in GG-NER R-HSA-5696400 2.344704e-01 0.630 0 0
Late endosomal microautophagy R-HSA-9615710 2.784429e-01 0.555 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.117817e-01 0.506 0 0
Notch-HLH transcription pathway R-HSA-350054 3.117817e-01 0.506 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.538030e-01 0.451 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.538030e-01 0.451 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.538030e-01 0.451 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.111364e-01 0.386 0 0
DAG1 core M3 glycosylations R-HSA-8932505 4.111364e-01 0.386 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.111364e-01 0.386 0 0
Signaling by APC mutants R-HSA-4839744 4.111364e-01 0.386 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.111364e-01 0.386 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.111364e-01 0.386 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.111364e-01 0.386 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.111364e-01 0.386 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.055799e-01 0.296 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.055799e-01 0.296 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.055799e-01 0.296 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.055799e-01 0.296 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.055799e-01 0.296 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.452733e-01 0.351 0 0
ERKs are inactivated R-HSA-202670 4.452733e-01 0.351 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.452733e-01 0.351 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.876119e-01 0.541 0 0
Nucleosome assembly R-HSA-774815 2.876119e-01 0.541 0 0
GAB1 signalosome R-HSA-180292 4.076912e-01 0.390 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.076912e-01 0.390 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.364179e-01 0.473 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.782743e-01 0.320 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.782743e-01 0.320 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.782743e-01 0.320 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.782743e-01 0.320 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.782743e-01 0.320 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.782743e-01 0.320 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.782743e-01 0.320 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.782743e-01 0.320 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.529206e-01 0.257 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.529206e-01 0.257 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.529206e-01 0.257 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.529206e-01 0.257 0 0
PDE3B signalling R-HSA-165160 5.529206e-01 0.257 0 0
PKB-mediated events R-HSA-109703 5.529206e-01 0.257 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.529206e-01 0.257 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.529206e-01 0.257 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.529206e-01 0.257 0 0
Phosphorylation of Emi1 R-HSA-176417 5.529206e-01 0.257 0 0
Signaling by MAPK mutants R-HSA-9652817 5.529206e-01 0.257 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.716548e-01 0.430 0 0
HIV Transcription Initiation R-HSA-167161 3.716548e-01 0.430 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.716548e-01 0.430 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.241214e-01 0.373 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.893321e-01 0.410 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.775531e-01 0.423 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.069999e-01 0.390 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.100440e-01 0.292 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.346477e-01 0.362 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.615864e-01 0.442 0 0
Signaling by Erythropoietin R-HSA-9006335 4.680318e-01 0.330 0 0
mRNA Capping R-HSA-72086 4.680318e-01 0.330 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.680318e-01 0.330 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.421700e-01 0.354 0 0
Translation initiation complex formation R-HSA-72649 4.318353e-01 0.365 0 0
HDACs deacetylate histones R-HSA-3214815 4.479180e-01 0.349 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.104978e-01 0.292 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.104978e-01 0.292 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.957309e-01 0.225 0 0
STAT5 Activation R-HSA-9645135 5.957309e-01 0.225 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.957309e-01 0.225 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.957309e-01 0.225 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.639154e-01 0.334 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.563109e-01 0.341 0 0
Dual incision in TC-NER R-HSA-6782135 4.955622e-01 0.305 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.696467e-01 0.244 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.696467e-01 0.244 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.696467e-01 0.244 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.696467e-01 0.244 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.696467e-01 0.244 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.582579e-01 0.253 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.582579e-01 0.253 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.582579e-01 0.253 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.257764e-01 0.279 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.516647e-01 0.258 0 0
Striated Muscle Contraction R-HSA-390522 5.714703e-01 0.243 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.810578e-01 0.236 0 0
Phosphorylation of the APC/C R-HSA-176412 5.974144e-01 0.224 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.974144e-01 0.224 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.974144e-01 0.224 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.344442e-01 0.198 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.344442e-01 0.198 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.344442e-01 0.198 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.344442e-01 0.198 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.344442e-01 0.198 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.344442e-01 0.198 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.344442e-01 0.198 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.344442e-01 0.198 0 0
Recycling of eIF2:GDP R-HSA-72731 6.344442e-01 0.198 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.921066e-01 0.228 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.921066e-01 0.228 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.006171e-01 0.221 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.387695e-01 0.195 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.223861e-01 0.206 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.322542e-01 0.199 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.322542e-01 0.199 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.322542e-01 0.199 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 6.469063e-01 0.189 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.454899e-01 0.190 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.488494e-01 0.188 0 0
Cellular response to heat stress R-HSA-3371556 3.850950e-01 0.414 0 0
RNA Polymerase III Transcription R-HSA-74158 4.346477e-01 0.362 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.488494e-01 0.188 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.488494e-01 0.188 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.473052e-01 0.262 0 0
Signaling by EGFR R-HSA-177929 2.008138e-01 0.697 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.323364e-01 0.634 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.076912e-01 0.390 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.647375e-01 0.333 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.976319e-01 0.526 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.100440e-01 0.292 0 0
EGFR downregulation R-HSA-182971 5.106614e-01 0.292 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.292158e-01 0.276 0 0
Signaling by ERBB2 R-HSA-1227986 1.533079e-01 0.814 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.220198e-01 0.914 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.636445e-01 0.786 0 0
G0 and Early G1 R-HSA-1538133 1.876300e-01 0.727 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.319348e-01 0.880 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.200310e-01 0.658 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.680318e-01 0.330 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.033754e-01 0.692 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.907755e-01 0.229 0 0
ESR-mediated signaling R-HSA-8939211 1.770036e-01 0.752 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.664578e-01 0.574 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.601463e-01 0.337 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.150106e-01 0.668 0 0
Adipogenesis R-HSA-9843745 5.129182e-01 0.290 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.400116e-01 0.469 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.955622e-01 0.305 0 0
Integrin signaling R-HSA-354192 5.516647e-01 0.258 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.810578e-01 0.236 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.810578e-01 0.236 0 0
Interleukin-15 signaling R-HSA-8983432 4.782743e-01 0.320 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.071710e-01 0.513 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.538030e-01 0.451 0 0
Developmental Cell Lineages R-HSA-9734767 2.765040e-01 0.558 0 0
Formation of lateral plate mesoderm R-HSA-9758920 1.929237e-01 0.715 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.664578e-01 0.574 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.400116e-01 0.469 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.721713e-01 0.764 0 0
PI3K/AKT activation R-HSA-198203 3.759927e-01 0.425 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.111364e-01 0.386 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.890763e-01 0.539 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.529206e-01 0.257 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.347258e-01 0.272 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.108116e-01 0.292 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.853840e-01 0.545 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.141955e-01 0.383 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.160580e-01 0.210 0 0
Signaling by RAS mutants R-HSA-6802949 6.322542e-01 0.199 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.129404e-01 0.947 0 0
Formation of definitive endoderm R-HSA-9823730 4.601463e-01 0.337 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.605401e-01 0.584 0 0
Reelin signalling pathway R-HSA-8866376 1.572496e-01 0.803 0 0
Polymerase switching R-HSA-69091 2.190849e-01 0.659 0 0
Leading Strand Synthesis R-HSA-69109 2.190849e-01 0.659 0 0
RAF activation R-HSA-5673000 1.238030e-01 0.907 0 0
TGFBR3 expression R-HSA-9839394 2.049082e-01 0.688 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.538030e-01 0.451 0 0
Translesion Synthesis by POLH R-HSA-110320 4.341443e-01 0.362 0 0
Signaling by MST1 R-HSA-8852405 5.529206e-01 0.257 0 0
Separation of Sister Chromatids R-HSA-2467813 2.936008e-01 0.532 0 0
MET promotes cell motility R-HSA-8875878 4.731732e-01 0.325 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.418497e-01 0.266 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.412280e-01 0.850 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.018172e-01 0.396 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.862003e-01 0.413 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.862003e-01 0.413 0 0
Integration of provirus R-HSA-162592 4.452733e-01 0.351 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.400269e-01 0.268 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.448198e-01 0.191 0 0
TNF signaling R-HSA-75893 3.181155e-01 0.497 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.532613e-01 0.257 0 0
Activation of BH3-only proteins R-HSA-114452 1.586654e-01 0.800 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.076912e-01 0.390 0 0
Signal amplification R-HSA-392518 3.955401e-01 0.403 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.837985e-01 0.234 0 0
Hedgehog 'on' state R-HSA-5632684 2.765746e-01 0.558 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.572496e-01 0.803 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.929237e-01 0.715 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.449455e-01 0.839 0 0
Calcineurin activates NFAT R-HSA-2025928 3.400116e-01 0.469 0 0
DCC mediated attractive signaling R-HSA-418885 2.993562e-01 0.524 0 0
Activation of SMO R-HSA-5635838 3.265864e-01 0.486 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.055799e-01 0.296 0 0
PTK6 Down-Regulation R-HSA-8849472 5.055799e-01 0.296 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.976319e-01 0.526 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.600563e-01 0.796 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.529206e-01 0.257 0 0
Chylomicron remodeling R-HSA-8963901 5.100440e-01 0.292 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.075822e-01 0.390 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.895302e-01 0.310 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.405157e-01 0.267 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.957309e-01 0.225 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.779517e-01 0.238 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.030973e-01 0.220 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.269536e-01 0.203 0 0
IRS-mediated signalling R-HSA-112399 6.370738e-01 0.196 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.819438e-01 0.740 0 0
G1 Phase R-HSA-69236 5.994495e-01 0.222 0 0
Cyclin D associated events in G1 R-HSA-69231 5.994495e-01 0.222 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.028291e-01 0.693 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.714703e-01 0.243 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.120212e-01 0.291 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.933671e-01 0.714 0 0
mTORC1-mediated signalling R-HSA-166208 3.117817e-01 0.506 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.283930e-01 0.641 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.100440e-01 0.292 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.516647e-01 0.258 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.446300e-01 0.840 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.929237e-01 0.715 0 0
Inhibition of nitric oxide production R-HSA-9636249 3.953406e-01 0.403 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.034095e-01 0.518 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.532298e-01 0.344 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.055799e-01 0.296 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.344442e-01 0.198 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.488494e-01 0.188 0 0
DNA Repair R-HSA-73894 1.187582e-01 0.925 0 0
Mitotic Prophase R-HSA-68875 2.797862e-01 0.553 0 0
Prolonged ERK activation events R-HSA-169893 1.449455e-01 0.839 0 0
Signaling by ERBB4 R-HSA-1236394 1.302088e-01 0.885 0 0
Neurofascin interactions R-HSA-447043 2.294923e-01 0.639 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.106874e-01 0.956 0 0
Vasopressin-like receptors R-HSA-388479 4.532298e-01 0.344 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.844354e-01 0.546 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.247403e-01 0.648 0 0
Myogenesis R-HSA-525793 4.018172e-01 0.396 0 0
Signaling by ROBO receptors R-HSA-376176 3.125442e-01 0.505 0 0
Circadian clock R-HSA-9909396 1.717954e-01 0.765 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.452733e-01 0.351 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.562015e-01 0.448 0 0
Mitochondrial biogenesis R-HSA-1592230 5.569445e-01 0.254 0 0
Chromosome Maintenance R-HSA-73886 5.998490e-01 0.222 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.562015e-01 0.448 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.567287e-01 0.805 0 0
Signaling by SCF-KIT R-HSA-1433557 5.824428e-01 0.235 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.680318e-01 0.330 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.919691e-01 0.717 0 0
IGF1R signaling cascade R-HSA-2428924 5.862864e-01 0.232 0 0
S Phase R-HSA-69242 4.069663e-01 0.390 0 0
Ub-specific processing proteases R-HSA-5689880 3.799916e-01 0.420 0 0
Calmodulin induced events R-HSA-111933 1.470419e-01 0.833 0 0
Signaling by ALK in cancer R-HSA-9700206 2.247403e-01 0.648 0 0
MTOR signalling R-HSA-165159 3.893321e-01 0.410 0 0
Signaling by NOTCH1 R-HSA-1980143 4.702548e-01 0.328 0 0
G-protein mediated events R-HSA-112040 6.284827e-01 0.202 0 0
Axon guidance R-HSA-422475 1.252981e-01 0.902 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.230685e-01 0.910 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.605401e-01 0.584 0 0
NrCAM interactions R-HSA-447038 1.572496e-01 0.803 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.313266e-01 0.480 0 0
Interleukin-33 signaling R-HSA-9014843 3.313266e-01 0.480 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.313266e-01 0.480 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.271505e-01 0.896 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.449455e-01 0.839 0 0
Regulation of PTEN localization R-HSA-8948747 2.664578e-01 0.574 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.953406e-01 0.403 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.953406e-01 0.403 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.033754e-01 0.692 0 0
Regulation of KIT signaling R-HSA-1433559 2.722557e-01 0.565 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.400116e-01 0.469 0 0
CaM pathway R-HSA-111997 1.470419e-01 0.833 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.894440e-01 0.538 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.090827e-01 0.962 0 0
Signalling to ERKs R-HSA-187687 2.508326e-01 0.601 0 0
Bicarbonate transporters R-HSA-425381 4.111364e-01 0.386 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.055799e-01 0.296 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.055799e-01 0.296 0 0
snRNP Assembly R-HSA-191859 2.374104e-01 0.625 0 0
Metabolism of non-coding RNA R-HSA-194441 2.374104e-01 0.625 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 3.568204e-01 0.448 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.452733e-01 0.351 0 0
Signaling by AXIN mutants R-HSA-4839735 4.452733e-01 0.351 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.452733e-01 0.351 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.876119e-01 0.541 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.076912e-01 0.390 0 0
PKA activation R-HSA-163615 4.076912e-01 0.390 0 0
G2/M Checkpoints R-HSA-69481 1.928545e-01 0.715 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.758760e-01 0.425 0 0
NGF-independant TRKA activation R-HSA-187024 5.529206e-01 0.257 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.529206e-01 0.257 0 0
Sensory perception of salty taste R-HSA-9730628 5.529206e-01 0.257 0 0
Synthesis of PS R-HSA-1483101 5.529206e-01 0.257 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.925608e-01 0.406 0 0
Gastrulation R-HSA-9758941 3.264587e-01 0.486 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.957309e-01 0.225 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.957309e-01 0.225 0 0
PI3K Cascade R-HSA-109704 5.277050e-01 0.278 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.974144e-01 0.224 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.907755e-01 0.229 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.238128e-01 0.205 0 0
Metalloprotease DUBs R-HSA-5689901 6.243559e-01 0.205 0 0
Recycling pathway of L1 R-HSA-437239 6.480260e-01 0.188 0 0
Developmental Biology R-HSA-1266738 3.914873e-01 0.407 0 0
Membrane Trafficking R-HSA-199991 6.301092e-01 0.201 0 0
NGF-stimulated transcription R-HSA-9031628 2.070127e-01 0.684 0 0
Nervous system development R-HSA-9675108 1.843031e-01 0.734 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.006171e-01 0.221 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.349901e-01 0.475 0 0
Macroautophagy R-HSA-1632852 6.235402e-01 0.205 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.582579e-01 0.253 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.104978e-01 0.292 0 0
Post NMDA receptor activation events R-HSA-438064 4.988519e-01 0.302 0 0
Neurodegenerative Diseases R-HSA-8863678 1.876275e-01 0.727 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.876275e-01 0.727 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.649864e-01 0.248 0 0
Signaling by MET R-HSA-6806834 5.251412e-01 0.280 0 0
Ca-dependent events R-HSA-111996 2.420116e-01 0.616 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.639154e-01 0.334 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.714703e-01 0.243 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.344442e-01 0.198 0 0
HIV Infection R-HSA-162906 2.256119e-01 0.647 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.884374e-01 0.725 0 0
Long-term potentiation R-HSA-9620244 2.049082e-01 0.688 0 0
TRP channels R-HSA-3295583 2.226895e-01 0.652 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.759927e-01 0.425 0 0
Signal attenuation R-HSA-74749 3.759927e-01 0.425 0 0
DAG and IP3 signaling R-HSA-1489509 2.876119e-01 0.541 0 0
TBC/RABGAPs R-HSA-8854214 4.069999e-01 0.390 0 0
ERK/MAPK targets R-HSA-198753 4.856195e-01 0.314 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.409122e-01 0.618 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.582579e-01 0.253 0 0
Regulated Necrosis R-HSA-5218859 6.419976e-01 0.192 0 0
Cell junction organization R-HSA-446728 5.967808e-01 0.224 0 0
RMTs methylate histone arginines R-HSA-3214858 2.721733e-01 0.565 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.664578e-01 0.574 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.034095e-01 0.518 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.129404e-01 0.947 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.117817e-01 0.506 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.055799e-01 0.296 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.365670e-01 0.473 0 0
Signaling by LTK R-HSA-9842663 4.782743e-01 0.320 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.529206e-01 0.257 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.529206e-01 0.257 0 0
Programmed Cell Death R-HSA-5357801 1.516212e-01 0.819 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.894511e-01 0.538 0 0
Signaling by PTK6 R-HSA-8848021 2.894511e-01 0.538 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.540042e-01 0.451 0 0
L1CAM interactions R-HSA-373760 1.693190e-01 0.771 0 0
Apoptosis R-HSA-109581 1.497961e-01 0.824 0 0
Interleukin-7 signaling R-HSA-1266695 6.030973e-01 0.220 0 0
Cell-Cell communication R-HSA-1500931 6.467562e-01 0.189 0 0
Netrin-1 signaling R-HSA-373752 4.246236e-01 0.372 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.318449e-01 0.880 0 0
Downstream signal transduction R-HSA-186763 3.170255e-01 0.499 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.100440e-01 0.292 0 0
PLC beta mediated events R-HSA-112043 5.418497e-01 0.266 0 0
Regulation of BACH1 activity R-HSA-9708530 5.974144e-01 0.224 0 0
FLT3 Signaling R-HSA-9607240 3.540042e-01 0.451 0 0
Formation of the nephric duct R-HSA-9830364 3.793611e-01 0.421 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.104978e-01 0.292 0 0
Co-stimulation by CD28 R-HSA-389356 4.940400e-01 0.306 0 0
Cellular Senescence R-HSA-2559583 5.320705e-01 0.274 0 0
Inositol phosphate metabolism R-HSA-1483249 1.911386e-01 0.719 0 0
UCH proteinases R-HSA-5689603 6.084772e-01 0.216 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.238128e-01 0.205 0 0
Kinesins R-HSA-983189 1.533079e-01 0.814 0 0
Semaphorin interactions R-HSA-373755 4.225956e-01 0.374 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.605401e-01 0.584 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.929237e-01 0.715 0 0
Sensory perception of sour taste R-HSA-9729555 4.532298e-01 0.344 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.759927e-01 0.425 0 0
Interleukin-36 pathway R-HSA-9014826 5.055799e-01 0.296 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.055799e-01 0.296 0 0
Negative regulation of MET activity R-HSA-6807004 4.601463e-01 0.337 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.856195e-01 0.314 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.856195e-01 0.314 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.405157e-01 0.267 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.405157e-01 0.267 0 0
Abacavir transmembrane transport R-HSA-2161517 5.957309e-01 0.225 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.957309e-01 0.225 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.106614e-01 0.292 0 0
DNA strand elongation R-HSA-69190 5.313848e-01 0.275 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.810578e-01 0.236 0 0
VLDL clearance R-HSA-8964046 6.344442e-01 0.198 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.344442e-01 0.198 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.238128e-01 0.205 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.448198e-01 0.191 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.409122e-01 0.618 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.243559e-01 0.205 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.226895e-01 0.652 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.699331e-01 0.770 0 0
Signaling by TGFBR3 R-HSA-9839373 4.596077e-01 0.338 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.420904e-01 0.616 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.220198e-01 0.914 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.393603e-01 0.856 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.761484e-01 0.559 0 0
RET signaling R-HSA-8853659 2.675014e-01 0.573 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.294923e-01 0.639 0 0
Histamine receptors R-HSA-390650 3.953406e-01 0.403 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.351760e-01 0.869 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.401342e-01 0.620 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.856195e-01 0.314 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.405157e-01 0.267 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.516647e-01 0.258 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.488494e-01 0.188 0 0
Lagging Strand Synthesis R-HSA-69186 4.856195e-01 0.314 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.696467e-01 0.244 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.810578e-01 0.236 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.688412e-01 0.329 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.587961e-01 0.253 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.775531e-01 0.423 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.255673e-01 0.901 0 0
Glycolysis R-HSA-70171 5.603475e-01 0.252 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.853893e-01 0.732 0 0
NADPH regeneration R-HSA-389542 2.294923e-01 0.639 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.664578e-01 0.574 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.664578e-01 0.574 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.953406e-01 0.403 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.190849e-01 0.659 0 0
Interleukin-18 signaling R-HSA-9012546 3.034095e-01 0.518 0 0
Sodium/Proton exchangers R-HSA-425986 3.034095e-01 0.518 0 0
Dopamine receptors R-HSA-390651 4.532298e-01 0.344 0 0
Passive transport by Aquaporins R-HSA-432047 3.538030e-01 0.451 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.055799e-01 0.296 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.782743e-01 0.320 0 0
Relaxin receptors R-HSA-444821 5.529206e-01 0.257 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.799189e-01 0.420 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.540034e-01 0.343 0 0
Negative regulation of FLT3 R-HSA-9706369 5.974144e-01 0.224 0 0
Activation of TRKA receptors R-HSA-187015 6.344442e-01 0.198 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.344442e-01 0.198 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.344442e-01 0.198 0 0
Netrin mediated repulsion signals R-HSA-418886 6.344442e-01 0.198 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.243559e-01 0.205 0 0
PI Metabolism R-HSA-1483255 1.733094e-01 0.761 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.265864e-01 0.486 0 0
HDMs demethylate histones R-HSA-3214842 3.793611e-01 0.421 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.181155e-01 0.497 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.856195e-01 0.314 0 0
Sensory processing of sound R-HSA-9659379 3.799189e-01 0.420 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.292158e-01 0.276 0 0
Gene Silencing by RNA R-HSA-211000 5.355735e-01 0.271 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.313848e-01 0.275 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.318906e-01 0.880 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.057203e-01 0.687 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.242328e-01 0.489 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.547986e-01 0.810 0 0
G1/S-Specific Transcription R-HSA-69205 4.346477e-01 0.362 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 6.243559e-01 0.205 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.650549e-01 0.248 0 0
Diseases of DNA repair R-HSA-9675135 1.819438e-01 0.740 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.572496e-01 0.803 0 0
LGI-ADAM interactions R-HSA-5682910 1.684815e-01 0.773 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.101190e-01 0.958 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.452733e-01 0.351 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.032480e-01 0.518 0 0
OAS antiviral response R-HSA-8983711 4.782743e-01 0.320 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.529206e-01 0.257 0 0
Lipid particle organization R-HSA-8964572 5.957309e-01 0.225 0 0
Syndecan interactions R-HSA-3000170 5.582579e-01 0.253 0 0
CHL1 interactions R-HSA-447041 6.344442e-01 0.198 0 0
Synthesis of PG R-HSA-1483148 6.238128e-01 0.205 0 0
Signaling by TGFB family members R-HSA-9006936 4.290226e-01 0.368 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.894511e-01 0.538 0 0
CREB3 factors activate genes R-HSA-8874211 5.957309e-01 0.225 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.488494e-01 0.188 0 0
Physiological factors R-HSA-5578768 2.722557e-01 0.565 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.562015e-01 0.448 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.955401e-01 0.403 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.346477e-01 0.362 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.104978e-01 0.292 0 0
Zinc transporters R-HSA-435354 5.405157e-01 0.267 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.117817e-01 0.506 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.055799e-01 0.296 0 0
Growth hormone receptor signaling R-HSA-982772 5.582579e-01 0.253 0 0
tRNA processing in the nucleus R-HSA-6784531 5.568890e-01 0.254 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.725248e-01 0.429 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.055799e-01 0.296 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.181155e-01 0.497 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.974144e-01 0.224 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.722557e-01 0.565 0 0
Signaling by Leptin R-HSA-2586552 3.759927e-01 0.425 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.100440e-01 0.292 0 0
Interleukin-37 signaling R-HSA-9008059 1.586654e-01 0.800 0 0
Maturation of hRSV A proteins R-HSA-9828806 6.448198e-01 0.191 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.033754e-01 0.692 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.117817e-01 0.506 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.506765e-01 0.187 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.506765e-01 0.187 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.506765e-01 0.187 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.592233e-01 0.181 0 0
Stimuli-sensing channels R-HSA-2672351 6.611059e-01 0.180 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.626140e-01 0.179 0 0
Metal ion SLC transporters R-HSA-425410 6.633639e-01 0.178 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.644813e-01 0.178 0 0
Pyroptosis R-HSA-5620971 6.644813e-01 0.178 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.654086e-01 0.177 0 0
Regulation of beta-cell development R-HSA-186712 6.654086e-01 0.177 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.681503e-01 0.175 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.681503e-01 0.175 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.681503e-01 0.175 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.694523e-01 0.174 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.694523e-01 0.174 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.694523e-01 0.174 0 0
Interleukin-9 signaling R-HSA-8985947 6.694523e-01 0.174 0 0
Adrenoceptors R-HSA-390696 6.694523e-01 0.174 0 0
Regulation by c-FLIP R-HSA-3371378 6.694523e-01 0.174 0 0
Co-stimulation by ICOS R-HSA-9927354 6.694523e-01 0.174 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.694523e-01 0.174 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.694523e-01 0.174 0 0
Dimerization of procaspase-8 R-HSA-69416 6.694523e-01 0.174 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.694523e-01 0.174 0 0
Alpha-defensins R-HSA-1462054 6.694523e-01 0.174 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.694523e-01 0.174 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.720532e-01 0.173 0 0
PKA activation in glucagon signalling R-HSA-164378 6.725429e-01 0.172 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.725429e-01 0.172 0 0
Autophagy R-HSA-9612973 6.740216e-01 0.171 0 0
DNA Damage Bypass R-HSA-73893 6.782602e-01 0.169 0 0
DARPP-32 events R-HSA-180024 6.833380e-01 0.165 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.833380e-01 0.165 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.833380e-01 0.165 0 0
Signaling by Hedgehog R-HSA-5358351 6.922465e-01 0.160 0 0
Aquaporin-mediated transport R-HSA-445717 6.923076e-01 0.160 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.949210e-01 0.158 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.949210e-01 0.158 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.949210e-01 0.158 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.949210e-01 0.158 0 0
Regulation of signaling by CBL R-HSA-912631 6.949210e-01 0.158 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.949210e-01 0.158 0 0
Attenuation phase R-HSA-3371568 6.951428e-01 0.158 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.951428e-01 0.158 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.951428e-01 0.158 0 0
Aggrephagy R-HSA-9646399 6.951428e-01 0.158 0 0
EPH-Ephrin signaling R-HSA-2682334 6.966026e-01 0.157 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.989067e-01 0.156 0 0
CASP8 activity is inhibited R-HSA-5218900 7.011097e-01 0.154 0 0
Interleukin-21 signaling R-HSA-9020958 7.011097e-01 0.154 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.011097e-01 0.154 0 0
Unwinding of DNA R-HSA-176974 7.011097e-01 0.154 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.011097e-01 0.154 0 0
ARMS-mediated activation R-HSA-170984 7.011097e-01 0.154 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.011097e-01 0.154 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.011097e-01 0.154 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.011097e-01 0.154 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.011097e-01 0.154 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.011097e-01 0.154 0 0
Activation of the pre-replicative complex R-HSA-68962 7.013924e-01 0.154 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.013924e-01 0.154 0 0
Cilium Assembly R-HSA-5617833 7.017239e-01 0.154 0 0
HSF1-dependent transactivation R-HSA-3371571 7.067084e-01 0.151 0 0
MAPK family signaling cascades R-HSA-5683057 7.093423e-01 0.149 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.105419e-01 0.148 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.160183e-01 0.145 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.160183e-01 0.145 0 0
Nephrin family interactions R-HSA-373753 7.160183e-01 0.145 0 0
Signal transduction by L1 R-HSA-445144 7.160183e-01 0.145 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.165492e-01 0.145 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.186512e-01 0.143 0 0
Budding and maturation of HIV virion R-HSA-162588 7.186512e-01 0.143 0 0
Cargo concentration in the ER R-HSA-5694530 7.186512e-01 0.143 0 0
Trafficking of AMPA receptors R-HSA-399719 7.186512e-01 0.143 0 0
Opioid Signalling R-HSA-111885 7.188478e-01 0.143 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.188478e-01 0.143 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.202547e-01 0.143 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.253646e-01 0.139 0 0
MAP2K and MAPK activation R-HSA-5674135 7.253646e-01 0.139 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.253646e-01 0.139 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.253646e-01 0.139 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.253646e-01 0.139 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.253646e-01 0.139 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.281577e-01 0.138 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.285742e-01 0.138 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.297368e-01 0.137 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.297368e-01 0.137 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.297368e-01 0.137 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.297368e-01 0.137 0 0
Regulation of CDH11 function R-HSA-9762292 7.297368e-01 0.137 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.297368e-01 0.137 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.297368e-01 0.137 0 0
Arachidonate production from DAG R-HSA-426048 7.297368e-01 0.137 0 0
2-LTR circle formation R-HSA-164843 7.297368e-01 0.137 0 0
Maturation of spike protein R-HSA-9683686 7.297368e-01 0.137 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.297368e-01 0.137 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.297368e-01 0.137 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.297368e-01 0.137 0 0
Formation of apoptosome R-HSA-111458 7.297368e-01 0.137 0 0
Insulin receptor signalling cascade R-HSA-74751 7.298861e-01 0.137 0 0
Host Interactions of HIV factors R-HSA-162909 7.310508e-01 0.136 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.331916e-01 0.135 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.331916e-01 0.135 0 0
Meiotic synapsis R-HSA-1221632 7.333482e-01 0.135 0 0
Smooth Muscle Contraction R-HSA-445355 7.333482e-01 0.135 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.358746e-01 0.133 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.358746e-01 0.133 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.358746e-01 0.133 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.358746e-01 0.133 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.358746e-01 0.133 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.471156e-01 0.127 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.508255e-01 0.124 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.508255e-01 0.124 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.530725e-01 0.123 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.532962e-01 0.123 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.545343e-01 0.122 0 0
Interleukin-2 signaling R-HSA-9020558 7.556236e-01 0.122 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.556236e-01 0.122 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 7.556236e-01 0.122 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.556236e-01 0.122 0 0
Synthesis of PI R-HSA-1483226 7.556236e-01 0.122 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.556236e-01 0.122 0 0
Chylomicron assembly R-HSA-8963888 7.556236e-01 0.122 0 0
PECAM1 interactions R-HSA-210990 7.556236e-01 0.122 0 0
Prostanoid ligand receptors R-HSA-391908 7.556236e-01 0.122 0 0
Diseases of programmed cell death R-HSA-9645723 7.580322e-01 0.120 0 0
Rab regulation of trafficking R-HSA-9007101 7.644323e-01 0.117 0 0
Glucose metabolism R-HSA-70326 7.644323e-01 0.117 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.654857e-01 0.116 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.657703e-01 0.116 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.657703e-01 0.116 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.663534e-01 0.116 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.664174e-01 0.116 0 0
Amine ligand-binding receptors R-HSA-375280 7.664174e-01 0.116 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.720443e-01 0.112 0 0
FGFR2 alternative splicing R-HSA-6803529 7.720443e-01 0.112 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.720443e-01 0.112 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.720443e-01 0.112 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.789867e-01 0.108 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.790323e-01 0.108 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.790323e-01 0.108 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.790323e-01 0.108 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.790323e-01 0.108 0 0
Anchoring fibril formation R-HSA-2214320 7.790323e-01 0.108 0 0
Sodium/Calcium exchangers R-HSA-425561 7.790323e-01 0.108 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.799769e-01 0.108 0 0
Mitophagy R-HSA-5205647 7.799769e-01 0.108 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.799769e-01 0.108 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.799769e-01 0.108 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.799769e-01 0.108 0 0
Hedgehog 'off' state R-HSA-5610787 7.834230e-01 0.106 0 0
PTEN Regulation R-HSA-6807070 7.871430e-01 0.104 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.884535e-01 0.103 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.884535e-01 0.103 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.910140e-01 0.102 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.944538e-01 0.100 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.947719e-01 0.100 0 0
Reproduction R-HSA-1474165 7.949022e-01 0.100 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.001999e-01 0.097 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.001999e-01 0.097 0 0
Repression of WNT target genes R-HSA-4641265 8.001999e-01 0.097 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.001999e-01 0.097 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.001999e-01 0.097 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.001999e-01 0.097 0 0
Regulation of IFNG signaling R-HSA-877312 8.001999e-01 0.097 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.001999e-01 0.097 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.001999e-01 0.097 0 0
MET activates RAS signaling R-HSA-8851805 8.001999e-01 0.097 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.001999e-01 0.097 0 0
Estrogen biosynthesis R-HSA-193144 8.001999e-01 0.097 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.025106e-01 0.096 0 0
Extension of Telomeres R-HSA-180786 8.025589e-01 0.096 0 0
Signaling by Insulin receptor R-HSA-74752 8.032731e-01 0.095 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.038122e-01 0.095 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.038122e-01 0.095 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.038122e-01 0.095 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.038122e-01 0.095 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.062566e-01 0.094 0 0
GPVI-mediated activation cascade R-HSA-114604 8.062566e-01 0.094 0 0
Triglyceride catabolism R-HSA-163560 8.062566e-01 0.094 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.125855e-01 0.090 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.125855e-01 0.090 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.125855e-01 0.090 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.125855e-01 0.090 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.125855e-01 0.090 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.126909e-01 0.090 0 0
Plasma lipoprotein remodeling R-HSA-8963899 8.134887e-01 0.090 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.138210e-01 0.089 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.144945e-01 0.089 0 0
Tight junction interactions R-HSA-420029 8.181710e-01 0.087 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.181710e-01 0.087 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.181710e-01 0.087 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.181710e-01 0.087 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.183736e-01 0.087 0 0
Collagen chain trimerization R-HSA-8948216 8.183736e-01 0.087 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.185911e-01 0.087 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.193409e-01 0.087 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.193409e-01 0.087 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.193409e-01 0.087 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.193409e-01 0.087 0 0
Processing of SMDT1 R-HSA-8949664 8.193409e-01 0.087 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.193409e-01 0.087 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.193409e-01 0.087 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.193409e-01 0.087 0 0
Maturation of nucleoprotein R-HSA-9683610 8.193409e-01 0.087 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.222008e-01 0.085 0 0
Collagen degradation R-HSA-1442490 8.222008e-01 0.085 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.227036e-01 0.085 0 0
Gap junction trafficking and regulation R-HSA-157858 8.239615e-01 0.084 0 0
Meiosis R-HSA-1500620 8.245355e-01 0.084 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.245355e-01 0.084 0 0
PPARA activates gene expression R-HSA-1989781 8.259049e-01 0.083 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.278381e-01 0.082 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.298395e-01 0.081 0 0
G1/S Transition R-HSA-69206 8.309939e-01 0.080 0 0
Signaling by FGFR in disease R-HSA-1226099 8.312465e-01 0.080 0 0
Signaling by PDGF R-HSA-186797 8.314137e-01 0.080 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.315805e-01 0.080 0 0
MET activates PTK2 signaling R-HSA-8874081 8.315805e-01 0.080 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.315805e-01 0.080 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.315805e-01 0.080 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.337734e-01 0.079 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.339427e-01 0.079 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.344314e-01 0.079 0 0
Interferon Signaling R-HSA-913531 8.353707e-01 0.078 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.366492e-01 0.077 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.366492e-01 0.077 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.366492e-01 0.077 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.366492e-01 0.077 0 0
HDL assembly R-HSA-8963896 8.366492e-01 0.077 0 0
Signal regulatory protein family interactions R-HSA-391160 8.366492e-01 0.077 0 0
P2Y receptors R-HSA-417957 8.366492e-01 0.077 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.402337e-01 0.076 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.406784e-01 0.075 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.418165e-01 0.075 0 0
Meiotic recombination R-HSA-912446 8.434468e-01 0.074 0 0
Synthesis of DNA R-HSA-69239 8.440813e-01 0.074 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.440906e-01 0.074 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.440906e-01 0.074 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.440906e-01 0.074 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.440906e-01 0.074 0 0
Muscle contraction R-HSA-397014 8.441150e-01 0.074 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.449270e-01 0.073 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.470456e-01 0.072 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.506247e-01 0.070 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.509145e-01 0.070 0 0
Interleukin-2 family signaling R-HSA-451927 8.509145e-01 0.070 0 0
Generation of second messenger molecules R-HSA-202433 8.509145e-01 0.070 0 0
Glycogen metabolism R-HSA-8982491 8.509145e-01 0.070 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.523002e-01 0.069 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.523002e-01 0.069 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.523002e-01 0.069 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.523002e-01 0.069 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.523002e-01 0.069 0 0
Protein lipoylation R-HSA-9857492 8.523002e-01 0.069 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.523002e-01 0.069 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.523002e-01 0.069 0 0
p38MAPK events R-HSA-171007 8.523002e-01 0.069 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.523002e-01 0.069 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.523002e-01 0.069 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.523002e-01 0.069 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.523002e-01 0.069 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.523002e-01 0.069 0 0
Protein methylation R-HSA-8876725 8.523002e-01 0.069 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.524885e-01 0.069 0 0
Selective autophagy R-HSA-9663891 8.546621e-01 0.068 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.557507e-01 0.068 0 0
Insulin receptor recycling R-HSA-77387 8.557507e-01 0.068 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.605723e-01 0.065 0 0
Maturation of spike protein R-HSA-9694548 8.605723e-01 0.065 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.607843e-01 0.065 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.610830e-01 0.065 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.610830e-01 0.065 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.644372e-01 0.063 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.664525e-01 0.062 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.664525e-01 0.062 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.664525e-01 0.062 0 0
Killing mechanisms R-HSA-9664420 8.664525e-01 0.062 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.664525e-01 0.062 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.664525e-01 0.062 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.664525e-01 0.062 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.664525e-01 0.062 0 0
Atorvastatin ADME R-HSA-9754706 8.664525e-01 0.062 0 0
DNA methylation R-HSA-5334118 8.666087e-01 0.062 0 0
Platelet calcium homeostasis R-HSA-418360 8.666087e-01 0.062 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.666087e-01 0.062 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.666087e-01 0.062 0 0
Base Excision Repair R-HSA-73884 8.680741e-01 0.061 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.696765e-01 0.061 0 0
Intra-Golgi traffic R-HSA-6811438 8.696765e-01 0.061 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.696765e-01 0.061 0 0
Adherens junctions interactions R-HSA-418990 8.712164e-01 0.060 0 0
Kidney development R-HSA-9830369 8.717879e-01 0.060 0 0
Cardiac conduction R-HSA-5576891 8.720317e-01 0.059 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.741259e-01 0.058 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.743886e-01 0.058 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.757703e-01 0.058 0 0
DNA Replication R-HSA-69306 8.762098e-01 0.057 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.767112e-01 0.057 0 0
DAP12 signaling R-HSA-2424491 8.767112e-01 0.057 0 0
Signaling by NOTCH3 R-HSA-9012852 8.769921e-01 0.057 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.782513e-01 0.056 0 0
Depyrimidination R-HSA-73928 8.782513e-01 0.056 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.792495e-01 0.056 0 0
Glycine degradation R-HSA-6783984 8.792495e-01 0.056 0 0
Phase 2 - plateau phase R-HSA-5576893 8.792495e-01 0.056 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.792495e-01 0.056 0 0
Fibronectin matrix formation R-HSA-1566977 8.792495e-01 0.056 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.792495e-01 0.056 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.792495e-01 0.056 0 0
Response to metal ions R-HSA-5660526 8.792495e-01 0.056 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.792495e-01 0.056 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.792495e-01 0.056 0 0
Signaling by WNT R-HSA-195721 8.792953e-01 0.056 0 0
IRE1alpha activates chaperones R-HSA-381070 8.804508e-01 0.055 0 0
MHC class II antigen presentation R-HSA-2132295 8.809404e-01 0.055 0 0
Ion homeostasis R-HSA-5578775 8.843378e-01 0.053 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.843378e-01 0.053 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.854185e-01 0.053 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.854433e-01 0.053 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.862671e-01 0.052 0 0
Signaling by FGFR4 R-HSA-5654743 8.863209e-01 0.052 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.908209e-01 0.050 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.908209e-01 0.050 0 0
Glycogen storage diseases R-HSA-3229121 8.908209e-01 0.050 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.908209e-01 0.050 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.908209e-01 0.050 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.908209e-01 0.050 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.908209e-01 0.050 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.908209e-01 0.050 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.908209e-01 0.050 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.918444e-01 0.050 0 0
Influenza Infection R-HSA-168255 8.934192e-01 0.049 0 0
DAG1 glycosylations R-HSA-8931838 8.948283e-01 0.048 0 0
Signaling by WNT in cancer R-HSA-4791275 8.948283e-01 0.048 0 0
Signaling by VEGF R-HSA-194138 8.955508e-01 0.048 0 0
RSV-host interactions R-HSA-9833110 8.958926e-01 0.048 0 0
Collagen formation R-HSA-1474290 8.971892e-01 0.047 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.978886e-01 0.047 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.978969e-01 0.047 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.978969e-01 0.047 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 8.978969e-01 0.047 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.978969e-01 0.047 0 0
Interferon alpha/beta signaling R-HSA-909733 9.001394e-01 0.046 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.010391e-01 0.045 0 0
Signaling by FGFR3 R-HSA-5654741 9.010391e-01 0.045 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.012840e-01 0.045 0 0
Nephron development R-HSA-9831926 9.012840e-01 0.045 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.012840e-01 0.045 0 0
Apoptotic factor-mediated response R-HSA-111471 9.012840e-01 0.045 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.012840e-01 0.045 0 0
Mismatch Repair R-HSA-5358508 9.012840e-01 0.045 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.012840e-01 0.045 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.012840e-01 0.045 0 0
Platelet sensitization by LDL R-HSA-432142 9.012840e-01 0.045 0 0
Tie2 Signaling R-HSA-210993 9.012840e-01 0.045 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.012840e-01 0.045 0 0
Interferon gamma signaling R-HSA-877300 9.022397e-01 0.045 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.023085e-01 0.045 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.029278e-01 0.044 0 0
G-protein beta:gamma signalling R-HSA-397795 9.029278e-01 0.044 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.029278e-01 0.044 0 0
Triglyceride metabolism R-HSA-8979227 9.041245e-01 0.044 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.046805e-01 0.044 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.046805e-01 0.044 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.077338e-01 0.042 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.077338e-01 0.042 0 0
Cell-cell junction organization R-HSA-421270 9.087372e-01 0.042 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.091299e-01 0.041 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.099977e-01 0.041 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.100208e-01 0.041 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.104415e-01 0.041 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.104415e-01 0.041 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.107450e-01 0.041 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.107450e-01 0.041 0 0
Pyrimidine biosynthesis R-HSA-500753 9.107450e-01 0.041 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.107450e-01 0.041 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.107450e-01 0.041 0 0
Diseases of hemostasis R-HSA-9671793 9.107450e-01 0.041 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.107450e-01 0.041 0 0
Rap1 signalling R-HSA-392517 9.107450e-01 0.041 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.107450e-01 0.041 0 0
HDL remodeling R-HSA-8964058 9.107450e-01 0.041 0 0
Maturation of nucleoprotein R-HSA-9694631 9.107450e-01 0.041 1 1
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.107450e-01 0.041 0 0
The NLRP3 inflammasome R-HSA-844456 9.107450e-01 0.041 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.126084e-01 0.040 0 0
HCMV Early Events R-HSA-9609690 9.130903e-01 0.039 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.144078e-01 0.039 0 0
MAP kinase activation R-HSA-450294 9.155924e-01 0.038 0 0
Telomere Maintenance R-HSA-157579 9.163807e-01 0.038 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.174072e-01 0.037 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.174072e-01 0.037 0 0
Hyaluronan metabolism R-HSA-2142845 9.174072e-01 0.037 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.174072e-01 0.037 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.185705e-01 0.037 0 0
Protein ubiquitination R-HSA-8852135 9.192655e-01 0.037 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.192998e-01 0.037 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.192998e-01 0.037 0 0
Glycogen synthesis R-HSA-3322077 9.192998e-01 0.037 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.192998e-01 0.037 0 0
Protein hydroxylation R-HSA-9629569 9.192998e-01 0.037 0 0
Signaling by NODAL R-HSA-1181150 9.192998e-01 0.037 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.192998e-01 0.037 0 0
Intraflagellar transport R-HSA-5620924 9.199050e-01 0.036 0 0
GPER1 signaling R-HSA-9634597 9.199050e-01 0.036 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.208536e-01 0.036 0 0
PERK regulates gene expression R-HSA-381042 9.238610e-01 0.034 0 0
Oncogene Induced Senescence R-HSA-2559585 9.238610e-01 0.034 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.238610e-01 0.034 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.254239e-01 0.034 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.254239e-01 0.034 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.258187e-01 0.033 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.270350e-01 0.033 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.270350e-01 0.033 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.270350e-01 0.033 0 0
Signalling to RAS R-HSA-167044 9.270350e-01 0.033 0 0
Basigin interactions R-HSA-210991 9.270350e-01 0.033 0 0
HSF1 activation R-HSA-3371511 9.298370e-01 0.032 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.298370e-01 0.032 0 0
FLT3 signaling in disease R-HSA-9682385 9.298370e-01 0.032 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.298370e-01 0.032 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.305919e-01 0.031 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.340292e-01 0.030 0 0
Glutathione synthesis and recycling R-HSA-174403 9.340292e-01 0.030 0 0
Cellular response to hypoxia R-HSA-1234174 9.349155e-01 0.029 0 0
HCMV Late Events R-HSA-9610379 9.356890e-01 0.029 0 0
HCMV Infection R-HSA-9609646 9.367161e-01 0.028 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.397808e-01 0.027 0 0
Orc1 removal from chromatin R-HSA-68949 9.399520e-01 0.027 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.399520e-01 0.027 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.403534e-01 0.027 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.403534e-01 0.027 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.403534e-01 0.027 0 0
Signaling by KIT in disease R-HSA-9669938 9.403534e-01 0.027 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.403534e-01 0.027 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.403534e-01 0.027 0 0
Ethanol oxidation R-HSA-71384 9.403534e-01 0.027 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.403534e-01 0.027 0 0
LDL clearance R-HSA-8964038 9.403534e-01 0.027 0 0
Signaling by FGFR2 R-HSA-5654738 9.403554e-01 0.027 0 0
tRNA processing R-HSA-72306 9.408571e-01 0.026 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.425738e-01 0.026 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.431093e-01 0.025 0 0
Neuronal System R-HSA-112316 9.434887e-01 0.025 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.441805e-01 0.025 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.444329e-01 0.025 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.452116e-01 0.024 0 0
Stabilization of p53 R-HSA-69541 9.452116e-01 0.024 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.452116e-01 0.024 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.460717e-01 0.024 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.460717e-01 0.024 0 0
Carnitine shuttle R-HSA-200425 9.460717e-01 0.024 0 0
Interleukin-20 family signaling R-HSA-8854691 9.460717e-01 0.024 0 0
Biosynthesis of maresins R-HSA-9018682 9.460717e-01 0.024 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.466723e-01 0.024 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.473003e-01 0.024 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.481311e-01 0.023 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.481311e-01 0.023 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.481311e-01 0.023 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.495812e-01 0.022 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.495812e-01 0.022 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.512420e-01 0.022 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.512420e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.513579e-01 0.022 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.518199e-01 0.021 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.533937e-01 0.021 0 0
COPII-mediated vesicle transport R-HSA-204005 9.533937e-01 0.021 0 0
Interleukin-17 signaling R-HSA-448424 9.533937e-01 0.021 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.536169e-01 0.021 0 0
Interleukin-1 family signaling R-HSA-446652 9.540080e-01 0.020 0 0
Signaling by FGFR1 R-HSA-5654736 9.552626e-01 0.020 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.559169e-01 0.020 0 0
Hyaluronan degradation R-HSA-2160916 9.559169e-01 0.020 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.559169e-01 0.020 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.559169e-01 0.020 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.559169e-01 0.020 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.559169e-01 0.020 0 0
Laminin interactions R-HSA-3000157 9.559169e-01 0.020 0 0
Phospholipid metabolism R-HSA-1483257 9.561406e-01 0.019 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.564535e-01 0.019 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.573426e-01 0.019 0 0
Translation of Structural Proteins R-HSA-9683701 9.573426e-01 0.019 0 0
Regulation of CDH1 Function R-HSA-9764561 9.584739e-01 0.018 0 0
SLC transporter disorders R-HSA-5619102 9.592697e-01 0.018 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.598157e-01 0.018 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.599744e-01 0.018 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.601439e-01 0.018 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.601439e-01 0.018 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.601439e-01 0.018 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.601439e-01 0.018 0 0
Abacavir ADME R-HSA-2161522 9.601439e-01 0.018 0 0
Activation of GABAB receptors R-HSA-991365 9.607806e-01 0.017 0 0
GABA B receptor activation R-HSA-977444 9.607806e-01 0.017 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.607806e-01 0.017 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.615697e-01 0.017 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.621639e-01 0.017 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.621639e-01 0.017 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.621639e-01 0.017 0 0
Defective pyroptosis R-HSA-9710421 9.639517e-01 0.016 0 0
Packaging Of Telomere Ends R-HSA-171306 9.639657e-01 0.016 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.639657e-01 0.016 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.639657e-01 0.016 0 0
Cristae formation R-HSA-8949613 9.639657e-01 0.016 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.639657e-01 0.016 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.639657e-01 0.016 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.639657e-01 0.016 0 0
Triglyceride biosynthesis R-HSA-75109 9.639657e-01 0.016 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.639657e-01 0.016 0 0
Synthesis of PE R-HSA-1483213 9.639657e-01 0.016 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.639657e-01 0.016 0 0
Peptide chain elongation R-HSA-156902 9.662103e-01 0.015 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.668755e-01 0.015 0 0
Gap junction trafficking R-HSA-190828 9.668755e-01 0.015 0 0
DAP12 interactions R-HSA-2172127 9.668755e-01 0.015 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.669269e-01 0.015 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.673744e-01 0.014 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.673744e-01 0.014 0 0
Telomere Extension By Telomerase R-HSA-171319 9.674213e-01 0.014 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.674213e-01 0.014 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.674213e-01 0.014 0 0
Prednisone ADME R-HSA-9757110 9.674213e-01 0.014 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.674213e-01 0.014 0 0
Pyrimidine salvage R-HSA-73614 9.674213e-01 0.014 0 0
Inflammasomes R-HSA-622312 9.674213e-01 0.014 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.695704e-01 0.013 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.695704e-01 0.013 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.695704e-01 0.013 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.695704e-01 0.013 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.705457e-01 0.013 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.705457e-01 0.013 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.705457e-01 0.013 0 0
Glucagon-type ligand receptors R-HSA-420092 9.705457e-01 0.013 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.705457e-01 0.013 0 0
Translation of Structural Proteins R-HSA-9694635 9.712346e-01 0.013 1 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.715292e-01 0.013 0 0
Mitochondrial protein import R-HSA-1268020 9.715292e-01 0.013 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.720532e-01 0.012 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.722092e-01 0.012 0 0
Potential therapeutics for SARS R-HSA-9679191 9.730898e-01 0.012 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.733706e-01 0.012 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.733706e-01 0.012 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.733706e-01 0.012 0 0
Neurotransmitter clearance R-HSA-112311 9.733706e-01 0.012 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.738098e-01 0.012 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.740648e-01 0.011 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.743399e-01 0.011 0 0
Synthesis of PC R-HSA-1483191 9.743399e-01 0.011 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.756422e-01 0.011 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.756422e-01 0.011 1 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.759247e-01 0.011 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.759247e-01 0.011 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.759247e-01 0.011 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.759247e-01 0.011 0 0
PKR-mediated signaling R-HSA-9833482 9.767222e-01 0.010 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.768881e-01 0.010 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.772066e-01 0.010 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.773832e-01 0.010 0 0
Toll-like Receptor Cascades R-HSA-168898 9.775385e-01 0.010 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.780787e-01 0.010 1 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.782340e-01 0.010 0 0
Degradation of CDH1 R-HSA-9766229 9.783829e-01 0.009 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.783829e-01 0.009 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.796920e-01 0.009 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.796920e-01 0.009 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.800578e-01 0.009 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.803219e-01 0.009 0 0
Recycling of bile acids and salts R-HSA-159418 9.803219e-01 0.009 0 0
Nicotinate metabolism R-HSA-196807 9.806285e-01 0.008 0 0
Cellular response to chemical stress R-HSA-9711123 9.807318e-01 0.008 0 0
Vesicle-mediated transport R-HSA-5653656 9.807744e-01 0.008 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.808818e-01 0.008 0 0
Cellular responses to stress R-HSA-2262752 9.810338e-01 0.008 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.813547e-01 0.008 0 0
Eukaryotic Translation Termination R-HSA-72764 9.813547e-01 0.008 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.818056e-01 0.008 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.820633e-01 0.008 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.820795e-01 0.008 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.822097e-01 0.008 0 0
Heme degradation R-HSA-189483 9.822097e-01 0.008 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.823041e-01 0.008 0 0
Cellular response to starvation R-HSA-9711097 9.824399e-01 0.008 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.830771e-01 0.007 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.830771e-01 0.007 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.831764e-01 0.007 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.831764e-01 0.007 0 0
G alpha (s) signalling events R-HSA-418555 9.832125e-01 0.007 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.833135e-01 0.007 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.833135e-01 0.007 0 0
Gap junction assembly R-HSA-190861 9.839164e-01 0.007 0 0
Signaling by NOTCH2 R-HSA-1980145 9.839164e-01 0.007 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.839164e-01 0.007 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.846758e-01 0.007 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.846758e-01 0.007 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.846996e-01 0.007 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.846996e-01 0.007 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.846996e-01 0.007 0 0
Signaling by FGFR R-HSA-190236 9.847865e-01 0.007 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.854595e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.854595e-01 0.006 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.854595e-01 0.006 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.858347e-01 0.006 0 0
ECM proteoglycans R-HSA-3000178 9.858347e-01 0.006 0 0
Integration of energy metabolism R-HSA-163685 9.859980e-01 0.006 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.863327e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.868547e-01 0.006 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.870089e-01 0.006 0 0
Ion channel transport R-HSA-983712 9.870284e-01 0.006 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.871439e-01 0.006 0 0
G alpha (z) signalling events R-HSA-418597 9.871439e-01 0.006 0 0
Signaling by NOTCH R-HSA-157118 9.873712e-01 0.006 0 0
Cellular responses to stimuli R-HSA-8953897 9.875552e-01 0.005 0 0
Selenocysteine synthesis R-HSA-2408557 9.876165e-01 0.005 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.877536e-01 0.005 0 0
Ca2+ pathway R-HSA-4086398 9.879053e-01 0.005 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.881160e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.881160e-01 0.005 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.881160e-01 0.005 0 0
Cleavage of the damaged purine R-HSA-110331 9.881160e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.881160e-01 0.005 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.881160e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.881160e-01 0.005 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.882189e-01 0.005 0 0
Platelet degranulation R-HSA-114608 9.883305e-01 0.005 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.886085e-01 0.005 0 0
Dectin-2 family R-HSA-5621480 9.892060e-01 0.005 0 0
Synthesis of PA R-HSA-1483166 9.892060e-01 0.005 0 0
Viral mRNA Translation R-HSA-192823 9.892182e-01 0.005 0 0
Depurination R-HSA-73927 9.892564e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.892564e-01 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 9.895201e-01 0.005 0 0
Pentose phosphate pathway R-HSA-71336 9.902874e-01 0.004 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.904748e-01 0.004 0 0
Interleukin-12 signaling R-HSA-9020591 9.904748e-01 0.004 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.912195e-01 0.004 0 0
Diseases of Immune System R-HSA-5260271 9.912195e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.912195e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.912195e-01 0.004 0 0
Protein folding R-HSA-391251 9.916154e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.917074e-01 0.004 0 0
tRNA Aminoacylation R-HSA-379724 9.917074e-01 0.004 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.917074e-01 0.004 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.917074e-01 0.004 0 0
RNA Polymerase I Transcription R-HSA-73864 9.918860e-01 0.004 0 0
Cholesterol biosynthesis R-HSA-191273 9.918860e-01 0.004 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.920622e-01 0.003 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.924064e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.924076e-01 0.003 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.924245e-01 0.003 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.925196e-01 0.003 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.928241e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.928241e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.928241e-01 0.003 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.935129e-01 0.003 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.935129e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.935129e-01 0.003 0 0
Defensins R-HSA-1461973 9.941356e-01 0.003 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.941356e-01 0.003 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.941789e-01 0.003 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.942331e-01 0.003 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.942453e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.946986e-01 0.002 0 0
Transmission across Chemical Synapses R-HSA-112315 9.949897e-01 0.002 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.952076e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.956677e-01 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.956677e-01 0.002 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.956677e-01 0.002 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.956677e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.957581e-01 0.002 0 0
O-linked glycosylation of mucins R-HSA-913709 9.959239e-01 0.002 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.960837e-01 0.002 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.964053e-01 0.002 0 0
Interleukin-12 family signaling R-HSA-447115 9.964053e-01 0.002 0 0
Gluconeogenesis R-HSA-70263 9.964597e-01 0.002 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.965312e-01 0.002 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.966390e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.967997e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.967997e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.968004e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.968846e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.968846e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.968846e-01 0.001 0 0
SARS-CoV Infections R-HSA-9679506 9.969651e-01 0.001 1 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.971523e-01 0.001 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.973849e-01 0.001 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.973849e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.973849e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.973849e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.973974e-01 0.001 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.976170e-01 0.001 0 0
Signaling by NOTCH4 R-HSA-9013694 9.976217e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.976217e-01 0.001 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.976360e-01 0.001 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.976360e-01 0.001 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.977005e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.977334e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.978269e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.978269e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.978631e-01 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.978889e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.981226e-01 0.001 0 0
TCR signaling R-HSA-202403 9.981958e-01 0.001 0 0
Protein localization R-HSA-9609507 9.982731e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.983435e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.983435e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.983435e-01 0.001 0 0
Co-inhibition by PD-1 R-HSA-389948 9.986038e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.987386e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.988343e-01 0.001 0 0
rRNA processing R-HSA-72312 9.989236e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.989463e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.989487e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.989644e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.990476e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.990476e-01 0.000 0 0
Interleukin-1 signaling R-HSA-9020702 9.990577e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.991034e-01 0.000 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.992007e-01 0.000 0 0
Signaling by Interleukins R-HSA-449147 9.992047e-01 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 9.992966e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.992966e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.993929e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.994344e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.994352e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.994461e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.994764e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.994806e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.994806e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.995516e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.995516e-01 0.000 0 0
Leishmania phagocytosis R-HSA-9664417 9.995516e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.995733e-01 0.000 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.996346e-01 0.000 0 0
Neddylation R-HSA-8951664 9.996633e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.996814e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.997352e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.997567e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.997586e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.997995e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998292e-01 0.000 0 0
PCP/CE pathway R-HSA-4086400 9.998292e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998456e-01 0.000 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.998538e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.998552e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998552e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998739e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.998739e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999005e-01 0.000 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.999036e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999069e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.999223e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999236e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999313e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999379e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999379e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999457e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999506e-01 0.000 0 0
Downstream TCR signaling R-HSA-202424 9.999542e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999542e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999551e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999627e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999629e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999691e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999694e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999784e-01 0.000 1 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999796e-01 0.000 0 0
Regulation of insulin secretion R-HSA-422356 9.999833e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999850e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999872e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999890e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999910e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999918e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999955e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999976e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999983e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999984e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999985e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999986e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999986e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999987e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999988e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999990e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999990e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999990e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999992e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999992e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999992e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999994e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999996e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999998e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999998e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Immune System R-HSA-168256 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 1 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.317047e-08 7.880 0 0
Cell Cycle, Mitotic R-HSA-69278 1.078014e-07 6.967 0 0
Attenuation phase R-HSA-3371568 2.056153e-07 6.687 0 0
HSF1-dependent transactivation R-HSA-3371571 3.770630e-07 6.424 0 0
Cellular response to heat stress R-HSA-3371556 3.202871e-06 5.494 0 0
HSF1 activation R-HSA-3371511 5.119925e-06 5.291 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.810628e-06 5.167 0 0
M Phase R-HSA-68886 1.522469e-05 4.817 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.099309e-05 4.678 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.113049e-05 4.507 0 0
Cell Cycle Checkpoints R-HSA-69620 3.243117e-05 4.489 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.571289e-05 4.340 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.571289e-05 4.340 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.157705e-05 4.381 0 0
Mitotic Prometaphase R-HSA-68877 4.037366e-05 4.394 0 0
mRNA Splicing R-HSA-72172 6.255500e-05 4.204 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.967394e-05 4.001 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.636842e-04 3.786 0 0
Chromatin organization R-HSA-4839726 2.085032e-04 3.681 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.279284e-04 3.642 0 0
Signaling by ALK in cancer R-HSA-9700206 2.279284e-04 3.642 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.500744e-04 3.602 0 0
Mitotic Anaphase R-HSA-68882 3.541741e-04 3.451 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.840588e-04 3.416 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.135233e-04 3.383 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.223861e-04 3.206 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.643578e-04 3.178 0 0
Separation of Sister Chromatids R-HSA-2467813 7.300848e-04 3.137 0 0
Apoptotic execution phase R-HSA-75153 7.623734e-04 3.118 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.561633e-04 3.067 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.561633e-04 3.067 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.057633e-03 2.976 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.146869e-03 2.940 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.142742e-03 2.942 0 0
MTOR signalling R-HSA-165159 1.127078e-03 2.948 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.148049e-03 2.940 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.250155e-03 2.903 0 0
Chromatin modifying enzymes R-HSA-3247509 1.373981e-03 2.862 0 0
mTORC1-mediated signalling R-HSA-166208 1.562205e-03 2.806 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.781128e-03 2.749 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.781128e-03 2.749 0 0
Polo-like kinase mediated events R-HSA-156711 1.727039e-03 2.763 0 0
Metabolism of RNA R-HSA-8953854 1.895332e-03 2.722 0 0
mRNA 3'-end processing R-HSA-72187 2.009105e-03 2.697 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.478093e-03 2.606 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.659601e-03 2.575 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.753389e-03 2.560 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.850538e-03 2.545 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.137164e-03 2.383 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.221374e-03 2.375 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.406183e-03 2.356 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.515387e-03 2.345 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.028546e-03 2.299 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.634592e-03 2.178 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.634592e-03 2.178 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.634592e-03 2.178 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.634592e-03 2.178 0 0
ALK mutants bind TKIs R-HSA-9700645 5.926114e-03 2.227 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.887471e-03 2.230 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.921107e-03 2.228 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.740389e-03 2.241 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.920587e-03 2.160 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.920587e-03 2.160 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.862626e-03 2.232 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.667013e-03 2.176 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.367845e-03 2.133 0 0
G2/M Transition R-HSA-69275 7.696786e-03 2.114 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.950659e-03 2.100 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.041977e-03 2.044 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.754761e-03 2.011 0 0
G2/M Checkpoints R-HSA-69481 9.522125e-03 2.021 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.830899e-03 2.007 0 0
Formation of definitive endoderm R-HSA-9823730 1.021087e-02 1.991 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.084721e-02 1.965 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.094933e-02 1.961 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.112725e-02 1.954 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.125129e-02 1.949 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.209871e-02 1.917 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.225446e-02 1.912 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.295446e-02 1.888 0 0
Apoptosis R-HSA-109581 1.341081e-02 1.873 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.442884e-02 1.841 0 0
Centrosome maturation R-HSA-380287 1.357217e-02 1.867 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.473161e-02 1.832 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.550741e-02 1.809 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.533661e-02 1.814 0 0
Translation initiation complex formation R-HSA-72649 1.594887e-02 1.797 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.536469e-02 1.813 0 0
Cellular Senescence R-HSA-2559583 1.517130e-02 1.819 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.848685e-02 1.733 0 0
HDACs deacetylate histones R-HSA-3214815 1.780101e-02 1.750 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.870817e-02 1.728 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.870817e-02 1.728 0 0
Mitotic Prophase R-HSA-68875 1.765429e-02 1.753 0 0
Signaling by Hippo R-HSA-2028269 1.881168e-02 1.726 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.858127e-02 1.731 0 0
NGF-stimulated transcription R-HSA-9031628 1.858127e-02 1.731 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.903169e-02 1.721 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.980993e-02 1.703 0 0
Formation of axial mesoderm R-HSA-9796292 2.323218e-02 1.634 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.323218e-02 1.634 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.323218e-02 1.634 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.202922e-02 1.657 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.310166e-02 1.636 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.275204e-02 1.643 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.161544e-02 1.665 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.198298e-02 1.658 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.346661e-02 1.630 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.475010e-02 1.606 0 0
Neurodegenerative Diseases R-HSA-8863678 2.475010e-02 1.606 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.502108e-02 1.602 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.539415e-02 1.595 0 0
DNA Double Strand Break Response R-HSA-5693606 2.743894e-02 1.562 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.753635e-02 1.560 0 0
Protein ubiquitination R-HSA-8852135 2.770308e-02 1.557 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.899465e-02 1.538 0 0
Deubiquitination R-HSA-5688426 3.146396e-02 1.502 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.190897e-02 1.496 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.221492e-02 1.492 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.221492e-02 1.492 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.278030e-02 1.484 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.282159e-02 1.484 0 0
G-protein beta:gamma signalling R-HSA-397795 3.299068e-02 1.482 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.299068e-02 1.482 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.299068e-02 1.482 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.734573e-02 1.428 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.576327e-02 1.447 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.571491e-02 1.447 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.777994e-02 1.423 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.821961e-02 1.418 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.821961e-02 1.418 0 0
Semaphorin interactions R-HSA-373755 3.885624e-02 1.411 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.042088e-02 1.393 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.042088e-02 1.393 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.042088e-02 1.393 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.144072e-02 1.383 0 0
Phosphorylation of the APC/C R-HSA-176412 4.191046e-02 1.378 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.213803e-02 1.375 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.392290e-02 1.357 0 0
Signaling by APC mutants R-HSA-4839744 4.422080e-02 1.354 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.422080e-02 1.354 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.422080e-02 1.354 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.422080e-02 1.354 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.060438e-02 1.296 0 0
Signaling by ROBO receptors R-HSA-376176 5.017559e-02 1.300 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.245083e-02 1.280 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.266776e-02 1.278 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.427888e-02 1.265 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.427888e-02 1.265 0 0
Signaling by AXIN mutants R-HSA-4839735 5.427888e-02 1.265 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.427888e-02 1.265 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 5.491522e-02 1.260 0 0
Cellular responses to stimuli R-HSA-8953897 5.572046e-02 1.254 0 0
Programmed Cell Death R-HSA-5357801 5.731023e-02 1.242 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.785859e-02 1.238 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.798624e-02 1.237 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.798624e-02 1.237 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.855434e-02 1.232 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.540621e-02 1.184 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.540621e-02 1.184 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.855434e-02 1.232 0 0
Kinesins R-HSA-983189 5.955746e-02 1.225 0 0
Cellular responses to stress R-HSA-2262752 5.880887e-02 1.231 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.955746e-02 1.225 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.546707e-02 1.184 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.546707e-02 1.184 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.546707e-02 1.184 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.546707e-02 1.184 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.546707e-02 1.184 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.546707e-02 1.184 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.546707e-02 1.184 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.761455e-02 1.170 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.775717e-02 1.109 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.762757e-02 1.110 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.176721e-02 1.144 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.583703e-02 1.120 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.160685e-02 1.145 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.978798e-02 1.156 0 0
S Phase R-HSA-69242 7.056460e-02 1.151 0 0
DNA Repair R-HSA-73894 6.969089e-02 1.157 0 0
Signaling by TGFBR3 R-HSA-9839373 7.176721e-02 1.144 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.152848e-02 1.146 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.862113e-02 1.104 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.854104e-02 1.105 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.311110e-02 1.136 0 0
G0 and Early G1 R-HSA-1538133 6.985787e-02 1.156 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.445309e-02 1.128 0 0
Nervous system development R-HSA-9675108 7.107013e-02 1.148 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.934477e-02 1.100 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 8.079576e-02 1.093 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.079576e-02 1.093 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.412200e-02 1.075 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.412200e-02 1.075 0 0
Striated Muscle Contraction R-HSA-390522 8.588054e-02 1.066 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.588054e-02 1.066 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.599063e-02 1.066 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.611815e-02 1.065 0 0
Cellular response to hypoxia R-HSA-1234174 8.713025e-02 1.060 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.866937e-02 1.052 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.912569e-02 1.050 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.945518e-02 1.048 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 8.945518e-02 1.048 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.709130e-01 0.767 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.709130e-01 0.767 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.709130e-01 0.767 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.709130e-01 0.767 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.709130e-01 0.767 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.709130e-01 0.767 0 0
Hereditary fructose intolerance R-HSA-5657560 1.709130e-01 0.767 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.709130e-01 0.767 0 0
Regulation of gap junction activity R-HSA-191650 1.096098e-01 0.960 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.096098e-01 0.960 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.096098e-01 0.960 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.096098e-01 0.960 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.096098e-01 0.960 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.450879e-01 0.611 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.450879e-01 0.611 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.450879e-01 0.611 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.450879e-01 0.611 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.450879e-01 0.611 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.450879e-01 0.611 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.450879e-01 0.611 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.450879e-01 0.611 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.450879e-01 0.611 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.450879e-01 0.611 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.406262e-01 0.852 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.406262e-01 0.852 0 0
IRS activation R-HSA-74713 1.406262e-01 0.852 0 0
G2 Phase R-HSA-68911 1.406262e-01 0.852 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.406262e-01 0.852 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.406262e-01 0.852 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.406262e-01 0.852 0 0
Lipophagy R-HSA-9613354 1.045019e-01 0.981 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.045019e-01 0.981 0 0
Phosphorylation of Emi1 R-HSA-176417 1.732210e-01 0.761 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.126307e-01 0.505 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.126307e-01 0.505 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.126307e-01 0.505 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.126307e-01 0.505 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.126307e-01 0.505 0 0
2-LTR circle formation R-HSA-164843 1.244186e-01 0.905 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.068640e-01 0.684 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.068640e-01 0.684 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.068640e-01 0.684 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.068640e-01 0.684 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.054777e-01 0.977 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.207992e-01 0.918 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.677994e-01 0.775 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.411073e-01 0.618 0 0
PTK6 Expression R-HSA-8849473 2.411073e-01 0.618 0 0
SOS-mediated signalling R-HSA-112412 2.411073e-01 0.618 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.411073e-01 0.618 0 0
Recycling of eIF2:GDP R-HSA-72731 2.411073e-01 0.618 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.741340e-01 0.427 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.741340e-01 0.427 0 0
Classical Kir channels R-HSA-1296053 3.741340e-01 0.427 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.741340e-01 0.427 0 0
MET activates PTPN11 R-HSA-8865999 3.741340e-01 0.427 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.741340e-01 0.427 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.741340e-01 0.427 0 0
Invadopodia formation R-HSA-8941237 3.741340e-01 0.427 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 3.741340e-01 0.427 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 3.741340e-01 0.427 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 3.741340e-01 0.427 0 0
Disorders of Developmental Biology R-HSA-9675151 1.370105e-01 0.863 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.370105e-01 0.863 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.909270e-01 0.719 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.909270e-01 0.719 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.909270e-01 0.719 0 0
Pervasive developmental disorders R-HSA-9005895 1.909270e-01 0.719 0 0
Disorders of Nervous System Development R-HSA-9697154 1.909270e-01 0.719 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.755745e-01 0.560 0 0
Formation of annular gap junctions R-HSA-196025 2.755745e-01 0.560 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.147934e-01 0.668 0 0
Late endosomal microautophagy R-HSA-9615710 1.144860e-01 0.941 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.038195e-01 0.984 0 0
Activation of the pre-replicative complex R-HSA-68962 1.259069e-01 0.900 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.259069e-01 0.900 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.902591e-01 0.721 0 0
ARMS-mediated activation R-HSA-170984 3.099518e-01 0.509 0 0
Gap junction degradation R-HSA-190873 3.099518e-01 0.509 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.301375e-01 0.366 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 4.301375e-01 0.366 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.301375e-01 0.366 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.301375e-01 0.366 0 0
Nucleotide catabolism defects R-HSA-9735786 4.301375e-01 0.366 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.301375e-01 0.366 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.301375e-01 0.366 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.301375e-01 0.366 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.378576e-01 0.861 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.378576e-01 0.861 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.641218e-01 0.578 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.641218e-01 0.578 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.843503e-01 0.734 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.632568e-01 0.787 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.439796e-01 0.463 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.439796e-01 0.463 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.003343e-01 0.698 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.003343e-01 0.698 0 0
Orc1 removal from chromatin R-HSA-68949 1.159352e-01 0.936 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.159352e-01 0.936 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.892944e-01 0.539 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.566023e-01 0.805 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.488029e-01 0.604 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.244869e-01 0.905 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.244869e-01 0.905 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.335981e-01 0.632 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.146285e-01 0.502 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.811328e-01 0.318 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.811328e-01 0.318 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.811328e-01 0.318 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.811328e-01 0.318 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.811328e-01 0.318 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.811328e-01 0.318 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.811328e-01 0.318 0 0
Defective F9 activation R-HSA-9673221 4.811328e-01 0.318 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.520816e-01 0.818 0 0
G1/S-Specific Transcription R-HSA-69205 2.192922e-01 0.659 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.507820e-01 0.601 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.369475e-01 0.863 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.720125e-01 0.764 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.400040e-01 0.469 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.400040e-01 0.469 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.400040e-01 0.469 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.105333e-01 0.508 0 0
Deadenylation of mRNA R-HSA-429947 3.105333e-01 0.508 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.101775e-01 0.387 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.101775e-01 0.387 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.101775e-01 0.387 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.327000e-01 0.633 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.327000e-01 0.633 0 0
Nucleosome assembly R-HSA-774815 2.327000e-01 0.633 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.816112e-01 0.741 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.649408e-01 0.577 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.653108e-01 0.437 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.653108e-01 0.437 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.653108e-01 0.437 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.653108e-01 0.437 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.464520e-01 0.608 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.604470e-01 0.584 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.425781e-01 0.615 0 0
Repression of WNT target genes R-HSA-4641265 4.420394e-01 0.355 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.275674e-01 0.278 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.275674e-01 0.278 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.275674e-01 0.278 0 0
PKB-mediated events R-HSA-109703 5.275674e-01 0.278 0 0
PDE3B signalling R-HSA-165160 5.275674e-01 0.278 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.275674e-01 0.278 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.275674e-01 0.278 0 0
Signaling by MAPK mutants R-HSA-9652817 5.275674e-01 0.278 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.500624e-01 0.602 0 0
Cristae formation R-HSA-8949613 3.734822e-01 0.428 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.289505e-01 0.483 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.437355e-01 0.613 0 0
HIV elongation arrest and recovery R-HSA-167287 3.944316e-01 0.404 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.944316e-01 0.404 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.332056e-01 0.477 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.332056e-01 0.477 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.769333e-01 0.424 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.398739e-01 0.357 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.398739e-01 0.357 0 0
Lagging Strand Synthesis R-HSA-69186 4.398739e-01 0.357 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.398739e-01 0.357 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.481407e-01 0.458 0 0
Meiotic synapsis R-HSA-1221632 3.481407e-01 0.458 0 0
DNA methylation R-HSA-5334118 4.152679e-01 0.382 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.152679e-01 0.382 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.785136e-01 0.555 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.785136e-01 0.555 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.946363e-01 0.404 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.946363e-01 0.404 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.027534e-01 0.299 0 0
Removal of the Flap Intermediate R-HSA-69166 5.027534e-01 0.299 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.027534e-01 0.299 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.698490e-01 0.244 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.698490e-01 0.244 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.698490e-01 0.244 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.698490e-01 0.244 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.698490e-01 0.244 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.385485e-01 0.470 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.876790e-01 0.312 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.314670e-01 0.275 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.314670e-01 0.275 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.314670e-01 0.275 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.314670e-01 0.275 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.968190e-01 0.401 0 0
snRNP Assembly R-HSA-191859 4.384324e-01 0.358 0 0
Metabolism of non-coding RNA R-HSA-194441 4.384324e-01 0.358 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.853879e-01 0.314 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.388674e-01 0.358 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.160880e-01 0.287 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.590263e-01 0.253 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.590263e-01 0.253 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.083488e-01 0.216 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.083488e-01 0.216 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.083488e-01 0.216 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.083488e-01 0.216 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.083488e-01 0.216 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.083488e-01 0.216 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.083488e-01 0.216 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.083488e-01 0.216 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.353031e-01 0.271 0 0
Dual Incision in GG-NER R-HSA-5696400 5.353031e-01 0.271 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.553911e-01 0.255 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.553911e-01 0.255 0 0
G protein gated Potassium channels R-HSA-1296059 5.553911e-01 0.255 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.553911e-01 0.255 0 0
Viral mRNA Translation R-HSA-192823 5.020511e-01 0.299 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.854080e-01 0.233 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.268443e-01 0.278 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.542205e-01 0.256 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.767403e-01 0.239 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.725383e-01 0.242 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.839082e-01 0.234 0 0
Dual incision in TC-NER R-HSA-6782135 5.839082e-01 0.234 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.905132e-01 0.229 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.974339e-01 0.224 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.974339e-01 0.224 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.974339e-01 0.224 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.974339e-01 0.224 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.106020e-01 0.214 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.957409e-01 0.225 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.385485e-01 0.470 0 0
Integrin signaling R-HSA-354192 3.039634e-01 0.517 0 0
Chromosome Maintenance R-HSA-73886 2.891854e-01 0.539 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.853879e-01 0.314 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.684116e-01 0.774 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.497603e-01 0.347 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.497603e-01 0.347 0 0
Extension of Telomeres R-HSA-180786 4.384324e-01 0.358 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.327000e-01 0.633 0 0
Signaling by EGFR R-HSA-177929 3.932772e-01 0.405 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.017512e-01 0.695 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.749847e-01 0.426 0 0
EGFR downregulation R-HSA-182971 2.682695e-01 0.571 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.539064e-01 0.257 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.539064e-01 0.257 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.664014e-01 0.331 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.539109e-01 0.813 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.566023e-01 0.805 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.612609e-01 0.792 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.275674e-01 0.278 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.153302e-01 0.382 0 0
Ribosome-associated quality control R-HSA-9948299 2.904296e-01 0.537 0 0
Telomere Extension By Telomerase R-HSA-171319 6.174537e-01 0.209 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.666621e-01 0.574 0 0
Nucleotide Excision Repair R-HSA-5696398 8.992021e-02 1.046 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.843503e-01 0.734 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.734822e-01 0.428 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.187528e-01 0.660 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.763980e-01 0.424 0 0
RNA Polymerase III Transcription R-HSA-74158 3.769333e-01 0.424 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.083488e-01 0.216 0 0
DNA strand elongation R-HSA-69190 1.503158e-01 0.823 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.612609e-01 0.792 0 0
Aggrephagy R-HSA-9646399 2.806728e-01 0.552 0 0
Developmental Cell Lineages R-HSA-9734767 4.120211e-01 0.385 0 0
Integration of provirus R-HSA-162592 1.677994e-01 0.775 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.290439e-01 0.889 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.781674e-01 0.422 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.359396e-01 0.361 0 0
Synthesis of DNA R-HSA-69239 1.563955e-01 0.806 0 0
Signaling by ERBB2 R-HSA-1227986 1.930779e-01 0.714 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.299888e-01 0.886 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.147934e-01 0.668 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.632568e-01 0.787 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.937533e-01 0.713 0 0
RET signaling R-HSA-8853659 3.769333e-01 0.424 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.334100e-01 0.273 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.767403e-01 0.239 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.905132e-01 0.229 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.121637e-01 0.673 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.121637e-01 0.673 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.406262e-01 0.852 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.411073e-01 0.618 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.147934e-01 0.668 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.641218e-01 0.578 0 0
PI3K/AKT activation R-HSA-198203 3.439796e-01 0.463 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.691271e-01 0.570 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.101775e-01 0.387 0 0
Peptide chain elongation R-HSA-156902 3.043813e-01 0.517 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.106020e-01 0.214 0 0
G1/S Transition R-HSA-69206 1.152472e-01 0.938 0 0
RNA Polymerase I Transcription R-HSA-73864 1.156486e-01 0.937 0 0
Homology Directed Repair R-HSA-5693538 1.826950e-01 0.738 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.176320e-01 0.209 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.640645e-01 0.439 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.359396e-01 0.361 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.633464e-01 0.440 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.244186e-01 0.905 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.370105e-01 0.863 0 0
TGFBR3 expression R-HSA-9839394 1.688608e-01 0.772 0 0
DARPP-32 events R-HSA-180024 2.335981e-01 0.632 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.055628e-01 0.687 0 0
PKA activation R-HSA-163615 3.653108e-01 0.437 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.420394e-01 0.355 0 0
Signaling by MST1 R-HSA-8852405 5.275674e-01 0.278 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.275674e-01 0.278 0 0
RAF activation R-HSA-5673000 3.403039e-01 0.468 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.503870e-01 0.601 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.380839e-01 0.471 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.314670e-01 0.275 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.978142e-01 0.526 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.856850e-01 0.731 0 0
Nuclear RNA decay R-HSA-9930044 1.632568e-01 0.787 0 0
G alpha (12/13) signalling events R-HSA-416482 2.904066e-01 0.537 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.902591e-01 0.721 0 0
UCH proteinases R-HSA-5689603 2.672141e-01 0.573 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.068640e-01 0.684 0 0
Nuclear import of Rev protein R-HSA-180746 9.461315e-02 1.024 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.003343e-01 0.698 0 0
Degradation of DVL R-HSA-4641258 3.952514e-01 0.403 0 0
Cyclin D associated events in G1 R-HSA-69231 3.617100e-01 0.442 0 0
G1 Phase R-HSA-69236 3.617100e-01 0.442 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.758804e-01 0.755 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.245614e-01 0.489 0 0
ESR-mediated signaling R-HSA-8939211 5.346019e-01 0.272 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.710396e-01 0.767 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.005803e-01 0.221 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.369475e-01 0.863 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.709130e-01 0.767 0 0
Sensory perception of sour taste R-HSA-9729555 1.096098e-01 0.960 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.732210e-01 0.761 0 0
Adrenoceptors R-HSA-390696 2.755745e-01 0.560 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.811328e-01 0.318 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.811328e-01 0.318 0 0
Activation of AKT2 R-HSA-165158 4.811328e-01 0.318 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.400040e-01 0.469 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.087972e-01 0.680 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.966072e-01 0.528 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.420394e-01 0.355 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.620904e-01 0.582 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.537676e-01 0.596 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.027534e-01 0.299 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.353031e-01 0.271 0 0
Tight junction interactions R-HSA-420029 5.553911e-01 0.255 0 0
Circadian clock R-HSA-9909396 1.625887e-01 0.789 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.760012e-01 0.754 0 0
DNA Replication R-HSA-69306 4.364586e-01 0.360 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.259069e-01 0.900 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.679644e-01 0.572 0 0
Activation of BH3-only proteins R-HSA-114452 1.259069e-01 0.900 0 0
Prolonged ERK activation events R-HSA-169893 2.892944e-01 0.539 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.683011e-01 0.245 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.101775e-01 0.387 0 0
PTEN Regulation R-HSA-6807070 1.535788e-01 0.814 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.359396e-01 0.361 0 0
Signaling by NOTCH1 R-HSA-1980143 3.894855e-01 0.410 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.755745e-01 0.560 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.641218e-01 0.578 0 0
Activation of C3 and C5 R-HSA-174577 4.811328e-01 0.318 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.451041e-01 0.838 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.169961e-01 0.932 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.524756e-01 0.453 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.275674e-01 0.278 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.876790e-01 0.312 0 0
Eukaryotic Translation Termination R-HSA-72764 4.085729e-01 0.389 0 0
HATs acetylate histones R-HSA-3214847 4.555676e-01 0.341 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.083488e-01 0.216 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.106020e-01 0.214 0 0
GPER1 signaling R-HSA-9634597 6.022084e-01 0.220 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.220757e-01 0.492 0 0
HIV Life Cycle R-HSA-162587 4.737872e-01 0.324 0 0
HDMs demethylate histones R-HSA-3214842 1.688608e-01 0.772 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.805981e-01 0.743 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.676662e-01 0.330 0 0
Co-stimulation by CD28 R-HSA-389356 1.601427e-01 0.795 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.657200e-01 0.781 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.151838e-01 0.667 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.966072e-01 0.528 0 0
Myogenesis R-HSA-525793 3.524756e-01 0.453 0 0
Rap1 signalling R-HSA-392517 3.904493e-01 0.408 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.452941e-01 0.462 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.169379e-01 0.210 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.079542e-01 0.512 0 0
Signaling by WNT in cancer R-HSA-4791275 4.766024e-01 0.322 0 0
Cilium Assembly R-HSA-5617833 2.470268e-01 0.607 0 0
Gene expression (Transcription) R-HSA-74160 1.732607e-01 0.761 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.932772e-01 0.405 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.853879e-01 0.314 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.353031e-01 0.271 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.676921e-01 0.572 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.676921e-01 0.572 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.141181e-01 0.503 0 0
Membrane Trafficking R-HSA-199991 1.885744e-01 0.725 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.400040e-01 0.469 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.367749e-01 0.864 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.524756e-01 0.453 0 0
Autophagy R-HSA-9612973 2.086146e-01 0.681 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.781674e-01 0.422 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.866492e-01 0.543 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.156486e-01 0.937 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.950269e-01 0.225 0 0
Neurexins and neuroligins R-HSA-6794361 2.055628e-01 0.687 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.114694e-01 0.953 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.898390e-01 0.538 0 0
HIV Infection R-HSA-162906 4.570569e-01 0.340 0 0
EPH-Ephrin signaling R-HSA-2682334 1.678686e-01 0.775 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.104303e-01 0.508 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.709130e-01 0.767 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.096098e-01 0.960 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.450879e-01 0.611 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.450879e-01 0.611 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.450879e-01 0.611 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.450879e-01 0.611 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.406262e-01 0.852 0 0
Unwinding of DNA R-HSA-176974 1.045019e-01 0.981 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.068640e-01 0.684 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.411073e-01 0.618 0 0
MET interacts with TNS proteins R-HSA-8875513 3.741340e-01 0.427 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.755745e-01 0.560 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.301375e-01 0.366 0 0
GABA synthesis R-HSA-888568 4.301375e-01 0.366 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.301375e-01 0.366 0 0
Smooth Muscle Contraction R-HSA-445355 1.244869e-01 0.905 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.146285e-01 0.502 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 3.774454e-01 0.423 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.653108e-01 0.437 0 0
PKA activation in glucagon signalling R-HSA-164378 3.653108e-01 0.437 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.806728e-01 0.552 0 0
Metalloprotease DUBs R-HSA-5689901 3.524756e-01 0.453 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.275674e-01 0.278 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.275674e-01 0.278 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.275674e-01 0.278 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.275674e-01 0.278 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.358426e-01 0.474 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.152679e-01 0.382 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.781674e-01 0.422 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.631467e-01 0.440 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.563989e-01 0.341 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.682632e-01 0.330 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.083488e-01 0.216 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.353031e-01 0.271 0 0
Cellular response to starvation R-HSA-9711097 4.830796e-01 0.316 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.983655e-01 0.223 0 0
Cell junction organization R-HSA-446728 4.443010e-01 0.352 0 0
Adherens junctions interactions R-HSA-418990 3.868404e-01 0.412 0 0
Cell-Cell communication R-HSA-1500931 4.875001e-01 0.312 0 0
Cell-cell junction organization R-HSA-421270 4.006397e-01 0.397 0 0
Macroautophagy R-HSA-1632852 1.660329e-01 0.780 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.524756e-01 0.453 0 0
Oncogene Induced Senescence R-HSA-2559585 3.586039e-01 0.445 0 0
Hedgehog 'off' state R-HSA-5610787 4.672603e-01 0.330 0 0
Selective autophagy R-HSA-9663891 3.043813e-01 0.517 0 0
Frs2-mediated activation R-HSA-170968 4.729248e-01 0.325 0 0
p75NTR signals via NF-kB R-HSA-193639 5.314670e-01 0.275 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.978142e-01 0.526 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.174537e-01 0.209 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.054777e-01 0.977 0 0
Ephrin signaling R-HSA-3928664 3.653108e-01 0.437 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.696439e-01 0.770 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.864371e-01 0.232 0 0
Platelet sensitization by LDL R-HSA-432142 1.718163e-01 0.765 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.099518e-01 0.509 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.273260e-01 0.895 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.420394e-01 0.355 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.156132e-01 0.381 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.160880e-01 0.287 0 0
Mitochondrial biogenesis R-HSA-1592230 5.701496e-01 0.244 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.566023e-01 0.805 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.763439e-01 0.239 0 0
Signal Transduction R-HSA-162582 1.999520e-01 0.699 0 0
Hedgehog 'on' state R-HSA-5632684 4.612597e-01 0.336 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.244186e-01 0.905 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.331009e-02 1.030 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.392414e-01 0.621 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.641218e-01 0.578 0 0
Signal attenuation R-HSA-74749 3.439796e-01 0.463 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.811328e-01 0.318 0 0
NRAGE signals death through JNK R-HSA-193648 1.520816e-01 0.818 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.039634e-01 0.517 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.398739e-01 0.357 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.746236e-01 0.561 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.854080e-01 0.233 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.965106e-01 0.304 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.028975e-01 0.299 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.539064e-01 0.257 0 0
Signaling by Hedgehog R-HSA-5358351 5.907451e-01 0.229 0 0
Signaling by NOTCH R-HSA-157118 3.962602e-01 0.402 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.939841e-01 0.405 0 0
rRNA processing R-HSA-72312 2.676340e-01 0.572 0 0
ABC-family proteins mediated transport R-HSA-382556 4.672603e-01 0.330 0 0
RUNX2 regulates bone development R-HSA-8941326 3.769333e-01 0.424 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.939199e-01 0.226 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.936777e-01 0.713 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.258007e-01 0.900 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.301375e-01 0.366 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.766540e-01 0.753 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.774454e-01 0.423 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.464520e-01 0.608 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.275674e-01 0.278 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.275674e-01 0.278 0 0
Ub-specific processing proteases R-HSA-5689880 3.478518e-01 0.459 0 0
Fructose catabolism R-HSA-70350 5.590263e-01 0.253 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.083488e-01 0.216 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.080351e-01 0.216 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.219095e-01 0.206 0 0
Muscle contraction R-HSA-397014 5.929129e-01 0.227 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.420394e-01 0.355 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.977448e-01 0.704 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.590263e-01 0.253 0 0
TBC/RABGAPs R-HSA-8854214 5.201691e-01 0.284 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.905132e-01 0.229 0 0
Axon guidance R-HSA-422475 9.539655e-02 1.020 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.118083e-01 0.506 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.192154e-01 0.659 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.976967e-01 0.303 0 0
Signaling by PTK6 R-HSA-8848021 4.976967e-01 0.303 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.450879e-01 0.611 0 0
Josephin domain DUBs R-HSA-5689877 1.244186e-01 0.905 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.068640e-01 0.684 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.741340e-01 0.427 0 0
TGFBR3 PTM regulation R-HSA-9839383 2.755745e-01 0.560 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.147934e-01 0.668 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.451892e-01 0.838 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.146285e-01 0.502 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.101775e-01 0.387 0 0
Cardiogenesis R-HSA-9733709 3.039634e-01 0.517 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.220757e-01 0.492 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.275674e-01 0.278 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.275674e-01 0.278 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.890683e-01 0.539 0 0
Abacavir transmembrane transport R-HSA-2161517 5.698490e-01 0.244 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.766024e-01 0.322 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.108269e-01 0.292 0 0
VLDL clearance R-HSA-8964046 6.083488e-01 0.216 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.083488e-01 0.216 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.541280e-01 0.256 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.541280e-01 0.256 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.582799e-01 0.801 0 0
PI Metabolism R-HSA-1483255 6.139444e-01 0.212 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.558445e-01 0.592 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.707935e-01 0.567 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.079686e-01 0.294 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.553911e-01 0.255 0 0
Protein hydroxylation R-HSA-9629569 4.153302e-01 0.382 0 0
Degradation of CDH1 R-HSA-9766229 6.176320e-01 0.209 0 0
Signaling by NOTCH3 R-HSA-9012852 2.425781e-01 0.615 0 0
Host Interactions of HIV factors R-HSA-162909 3.174642e-01 0.498 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.172714e-01 0.931 0 0
Regulation of TP53 Activity R-HSA-5633007 1.200675e-01 0.921 0 0
Gastrulation R-HSA-9758941 3.991193e-01 0.399 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.411073e-01 0.618 0 0
Suppression of apoptosis R-HSA-9635465 3.774454e-01 0.423 0 0
tRNA processing in the nucleus R-HSA-6784531 3.358426e-01 0.474 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.698490e-01 0.244 0 0
Selenocysteine synthesis R-HSA-2408557 4.789113e-01 0.320 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.541280e-01 0.256 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.250894e-01 0.204 0 0
Signaling by NTRKs R-HSA-166520 2.991533e-01 0.524 0 0
Signal transduction by L1 R-HSA-445144 4.153302e-01 0.382 0 0
PERK regulates gene expression R-HSA-381042 5.541280e-01 0.256 0 0
Diseases of programmed cell death R-HSA-9645723 3.043813e-01 0.517 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.761848e-01 0.322 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.374126e-01 0.472 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.411073e-01 0.618 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.301375e-01 0.366 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.439796e-01 0.463 0 0
Activation of RAC1 R-HSA-428540 4.101775e-01 0.387 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.966072e-01 0.528 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.275674e-01 0.278 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.275674e-01 0.278 0 0
Relaxin receptors R-HSA-444821 5.275674e-01 0.278 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.496730e-01 0.456 0 0
NADPH regeneration R-HSA-389542 5.698490e-01 0.244 0 0
Signaling by NOTCH4 R-HSA-9013694 3.633464e-01 0.440 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.336577e-01 0.477 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.965106e-01 0.304 0 0
Regulation of PTEN localization R-HSA-8948747 6.083488e-01 0.216 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.725383e-01 0.242 0 0
Degradation of AXIN R-HSA-4641257 5.905132e-01 0.229 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.905132e-01 0.229 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.974339e-01 0.224 0 0
Signaling by ALK R-HSA-201556 1.451892e-01 0.838 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.207992e-01 0.918 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.370105e-01 0.863 0 0
Maturation of nucleoprotein R-HSA-9683610 4.729248e-01 0.325 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.497603e-01 0.347 0 0
Protein methylation R-HSA-8876725 5.314670e-01 0.275 0 0
Activation of SMO R-HSA-5635838 5.590263e-01 0.253 0 0
Potential therapeutics for SARS R-HSA-9679191 5.079748e-01 0.294 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.957409e-01 0.225 0 0
Maturation of nucleoprotein R-HSA-9694631 1.902591e-01 0.721 1 1
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.876790e-01 0.312 0 0
Inositol phosphate metabolism R-HSA-1483249 6.124050e-01 0.213 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.876790e-01 0.312 0 0
Diseases of DNA repair R-HSA-9675135 5.703314e-01 0.244 0 0
Influenza Infection R-HSA-168255 2.393487e-01 0.621 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.411073e-01 0.618 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.099518e-01 0.509 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.099518e-01 0.509 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.099518e-01 0.509 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.494444e-01 0.603 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.653108e-01 0.437 0 0
PKR-mediated signaling R-HSA-9833482 2.087972e-01 0.680 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.275674e-01 0.278 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.729248e-01 0.325 0 0
Nef and signal transduction R-HSA-164944 5.698490e-01 0.244 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.314670e-01 0.275 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.160880e-01 0.287 0 0
CHL1 interactions R-HSA-447041 6.083488e-01 0.216 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.353031e-01 0.271 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.353031e-01 0.271 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.065234e-01 0.295 0 0
Regulation of Apoptosis R-HSA-169911 5.541280e-01 0.256 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.725383e-01 0.242 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.373260e-01 0.862 0 0
RMTs methylate histone arginines R-HSA-3214858 3.617100e-01 0.442 0 0
DAG and IP3 signaling R-HSA-1489509 5.539064e-01 0.257 0 0
Gene Silencing by RNA R-HSA-211000 5.585584e-01 0.253 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.250894e-01 0.204 0 0
Death Receptor Signaling R-HSA-73887 5.455087e-01 0.263 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.099518e-01 0.509 0 0
DCC mediated attractive signaling R-HSA-418885 2.641218e-01 0.578 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.488029e-01 0.604 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.590263e-01 0.253 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.474421e-01 0.262 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.174537e-01 0.209 0 0
Sensory processing of sound R-HSA-9659379 5.685709e-01 0.245 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.400040e-01 0.469 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.275674e-01 0.278 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.686785e-01 0.245 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.250894e-01 0.204 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.500624e-01 0.602 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.553860e-01 0.593 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.996934e-01 0.398 0 0
Signaling by Leptin R-HSA-2586552 3.439796e-01 0.463 0 0
Specification of primordial germ cells R-HSA-9827857 6.106020e-01 0.214 0 0
IRE1alpha activates chaperones R-HSA-381070 4.737624e-01 0.324 0 0
FLT3 Signaling R-HSA-9607240 4.676662e-01 0.330 0 0
Interleukin-12 signaling R-HSA-9020591 3.894855e-01 0.410 0 0
Interleukin-12 family signaling R-HSA-447115 4.120744e-01 0.385 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.002225e-01 0.222 0 0
Interleukin-7 signaling R-HSA-1266695 5.553911e-01 0.255 0 0
Stabilization of p53 R-HSA-69541 6.250894e-01 0.204 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.811328e-01 0.318 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.264496e-01 0.203 0 0
Aquaporin-mediated transport R-HSA-445717 6.264496e-01 0.203 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.264496e-01 0.203 0 0
PI3K Cascade R-HSA-109704 6.326966e-01 0.199 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.326966e-01 0.199 0 0
RNA Polymerase II Transcription R-HSA-73857 6.337459e-01 0.198 0 0
GAB1 signalosome R-HSA-180292 6.346097e-01 0.197 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.346097e-01 0.197 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.346097e-01 0.197 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.346097e-01 0.197 0 0
Mismatch Repair R-HSA-5358508 6.346097e-01 0.197 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 6.346097e-01 0.197 0 0
Signaling by Erythropoietin R-HSA-9006335 6.367873e-01 0.196 0 0
Heme signaling R-HSA-9707616 6.400573e-01 0.194 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.400573e-01 0.194 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.416645e-01 0.193 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.416645e-01 0.193 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.418090e-01 0.193 0 0
Meiosis R-HSA-1500620 6.422996e-01 0.192 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.434048e-01 0.192 0 0
Type I hemidesmosome assembly R-HSA-446107 6.434048e-01 0.192 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.434048e-01 0.192 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.434048e-01 0.192 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.434048e-01 0.192 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.434048e-01 0.192 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.434048e-01 0.192 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.434048e-01 0.192 0 0
MET receptor recycling R-HSA-8875656 6.434048e-01 0.192 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.434048e-01 0.192 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.434048e-01 0.192 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.434048e-01 0.192 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.434048e-01 0.192 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.434048e-01 0.192 0 0
Co-stimulation by ICOS R-HSA-9927354 6.434048e-01 0.192 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.434048e-01 0.192 0 0
RSK activation R-HSA-444257 6.434048e-01 0.192 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.434048e-01 0.192 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.435424e-01 0.191 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.473928e-01 0.189 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.554266e-01 0.183 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.554266e-01 0.183 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.554266e-01 0.183 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.554266e-01 0.183 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.574415e-01 0.182 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.574415e-01 0.182 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.574415e-01 0.182 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.574415e-01 0.182 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.574415e-01 0.182 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.577514e-01 0.182 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.577514e-01 0.182 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.577514e-01 0.182 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.617126e-01 0.179 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.617126e-01 0.179 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.628470e-01 0.179 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.652202e-01 0.177 0 0
IGF1R signaling cascade R-HSA-2428924 6.663654e-01 0.176 0 0
MAP2K and MAPK activation R-HSA-5674135 6.733437e-01 0.172 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.733437e-01 0.172 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.733437e-01 0.172 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.733437e-01 0.172 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.733437e-01 0.172 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.753249e-01 0.170 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.753249e-01 0.170 0 0
WNT mediated activation of DVL R-HSA-201688 6.753249e-01 0.170 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.753249e-01 0.170 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.753249e-01 0.170 0 0
Calcineurin activates NFAT R-HSA-2025928 6.753249e-01 0.170 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.753249e-01 0.170 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.753249e-01 0.170 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.753249e-01 0.170 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.753249e-01 0.170 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.753249e-01 0.170 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.753249e-01 0.170 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.753249e-01 0.170 0 0
Post NMDA receptor activation events R-HSA-438064 6.763444e-01 0.170 0 0
Platelet degranulation R-HSA-114608 6.781946e-01 0.169 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.790539e-01 0.168 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.791156e-01 0.168 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.791156e-01 0.168 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.791156e-01 0.168 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.791156e-01 0.168 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.791156e-01 0.168 0 0
Nephrin family interactions R-HSA-373753 6.791156e-01 0.168 0 0
Telomere Maintenance R-HSA-157579 6.813787e-01 0.167 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.868493e-01 0.163 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.906114e-01 0.161 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.906114e-01 0.161 0 0
Regulation of insulin secretion R-HSA-422356 6.915972e-01 0.160 0 0
Signaling by TGFB family members R-HSA-9006936 6.941450e-01 0.159 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.944415e-01 0.158 0 0
ABC transporter disorders R-HSA-5619084 6.944415e-01 0.158 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.996562e-01 0.155 0 0
G-protein activation R-HSA-202040 6.996562e-01 0.155 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.996562e-01 0.155 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.996562e-01 0.155 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.996562e-01 0.155 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.996562e-01 0.155 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.996562e-01 0.155 0 0
Defective pyroptosis R-HSA-9710421 7.030297e-01 0.153 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.043894e-01 0.152 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.043894e-01 0.152 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.043894e-01 0.152 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.043894e-01 0.152 0 0
DNA replication initiation R-HSA-68952 7.043894e-01 0.152 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.043894e-01 0.152 0 0
Binding and entry of HIV virion R-HSA-173107 7.043894e-01 0.152 0 0
Regulation of CDH11 function R-HSA-9762292 7.043894e-01 0.152 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.043894e-01 0.152 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.043894e-01 0.152 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.043894e-01 0.152 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.043894e-01 0.152 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.043894e-01 0.152 0 0
Pexophagy R-HSA-9664873 7.043894e-01 0.152 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.043894e-01 0.152 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.043894e-01 0.152 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.043894e-01 0.152 0 0
Interleukin-27 signaling R-HSA-9020956 7.043894e-01 0.152 0 0
Maturation of spike protein R-HSA-9683686 7.043894e-01 0.152 0 0
Formation of apoptosome R-HSA-111458 7.043894e-01 0.152 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.071605e-01 0.150 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.071605e-01 0.150 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.087539e-01 0.150 0 0
Glycolysis R-HSA-70171 7.114131e-01 0.148 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.151270e-01 0.146 0 0
Ion homeostasis R-HSA-5578775 7.151270e-01 0.146 0 0
Proteasome assembly R-HSA-9907900 7.171214e-01 0.144 0 0
Surfactant metabolism R-HSA-5683826 7.171214e-01 0.144 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.171214e-01 0.144 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.171214e-01 0.144 0 0
Netrin-1 signaling R-HSA-373752 7.171214e-01 0.144 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.190925e-01 0.143 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.210060e-01 0.142 0 0
Adipogenesis R-HSA-9843745 7.216720e-01 0.142 0 0
Signaling by WNT R-HSA-195721 7.229810e-01 0.141 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.230217e-01 0.141 0 0
IRS-mediated signalling R-HSA-112399 7.275014e-01 0.138 0 0
Regulation of CDH1 Function R-HSA-9764561 7.275014e-01 0.138 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.303867e-01 0.136 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.307139e-01 0.136 0 0
Somitogenesis R-HSA-9824272 7.307139e-01 0.136 0 0
PECAM1 interactions R-HSA-210990 7.308537e-01 0.136 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.308537e-01 0.136 0 0
vRNP Assembly R-HSA-192905 7.308537e-01 0.136 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.308537e-01 0.136 0 0
Synthesis of PI R-HSA-1483226 7.308537e-01 0.136 0 0
Bicarbonate transporters R-HSA-425381 7.308537e-01 0.136 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.308537e-01 0.136 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.308537e-01 0.136 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.308537e-01 0.136 0 0
Interleukin-2 signaling R-HSA-9020558 7.308537e-01 0.136 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.352425e-01 0.134 0 0
MHC class II antigen presentation R-HSA-2132295 7.352425e-01 0.134 0 0
FGFR2 alternative splicing R-HSA-6803529 7.374577e-01 0.132 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.374577e-01 0.132 0 0
Notch-HLH transcription pathway R-HSA-350054 7.374577e-01 0.132 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.374577e-01 0.132 0 0
Fructose metabolism R-HSA-5652084 7.374577e-01 0.132 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.376954e-01 0.132 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.379703e-01 0.132 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.382039e-01 0.132 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.382039e-01 0.132 0 0
Signaling by NOTCH2 R-HSA-1980145 7.382039e-01 0.132 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.382039e-01 0.132 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.382039e-01 0.132 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.438107e-01 0.129 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.438107e-01 0.129 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.438107e-01 0.129 0 0
Signaling by RAS mutants R-HSA-6802949 7.438107e-01 0.129 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.438107e-01 0.129 0 0
Opioid Signalling R-HSA-111885 7.485072e-01 0.126 0 0
Regulation of beta-cell development R-HSA-186712 7.510740e-01 0.124 0 0
Signalling to ERKs R-HSA-187687 7.527185e-01 0.123 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.527185e-01 0.123 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.547876e-01 0.122 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.547876e-01 0.122 0 0
Growth hormone receptor signaling R-HSA-982772 7.547876e-01 0.122 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.549502e-01 0.122 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.549502e-01 0.122 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.549502e-01 0.122 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.549502e-01 0.122 0 0
NF-kB is activated and signals survival R-HSA-209560 7.549502e-01 0.122 0 0
Plasmalogen biosynthesis R-HSA-75896 7.549502e-01 0.122 0 0
ERKs are inactivated R-HSA-202670 7.549502e-01 0.122 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.549502e-01 0.122 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.549502e-01 0.122 0 0
Developmental Biology R-HSA-1266738 7.567914e-01 0.121 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.595580e-01 0.119 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.595580e-01 0.119 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.595580e-01 0.119 0 0
Signaling by VEGF R-HSA-194138 7.595580e-01 0.119 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.622765e-01 0.118 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.622765e-01 0.118 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.622765e-01 0.118 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.622765e-01 0.118 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.622765e-01 0.118 0 0
GPVI-mediated activation cascade R-HSA-114604 7.665787e-01 0.115 0 0
Calmodulin induced events R-HSA-111933 7.665787e-01 0.115 0 0
CaM pathway R-HSA-111997 7.665787e-01 0.115 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.711204e-01 0.113 0 0
Complex III assembly R-HSA-9865881 7.711204e-01 0.113 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.711204e-01 0.113 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.711204e-01 0.113 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.711204e-01 0.113 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.711204e-01 0.113 0 0
PLC beta mediated events R-HSA-112043 7.730940e-01 0.112 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.730940e-01 0.112 0 0
Platelet homeostasis R-HSA-418346 7.740798e-01 0.111 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.760283e-01 0.110 0 0
Polymerase switching R-HSA-69091 7.768907e-01 0.110 0 0
Leading Strand Synthesis R-HSA-69109 7.768907e-01 0.110 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.768907e-01 0.110 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.768907e-01 0.110 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.768907e-01 0.110 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.768907e-01 0.110 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.768907e-01 0.110 0 0
Signaling by LTK R-HSA-9842663 7.768907e-01 0.110 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.768907e-01 0.110 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.768907e-01 0.110 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.768907e-01 0.110 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.768907e-01 0.110 0 0
Interleukin-35 Signalling R-HSA-8984722 7.768907e-01 0.110 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.768907e-01 0.110 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.797991e-01 0.108 0 0
Cleavage of the damaged purine R-HSA-110331 7.797991e-01 0.108 0 0
DNA Damage Bypass R-HSA-73893 7.801802e-01 0.108 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.801802e-01 0.108 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.801802e-01 0.108 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.830931e-01 0.106 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.864957e-01 0.104 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.864957e-01 0.104 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.864957e-01 0.104 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.864957e-01 0.104 0 0
Depurination R-HSA-73927 7.923960e-01 0.101 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.923960e-01 0.101 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.923960e-01 0.101 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.935920e-01 0.100 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.936792e-01 0.100 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.968679e-01 0.099 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.968679e-01 0.099 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.968679e-01 0.099 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.968679e-01 0.099 0 0
Diseases of nucleotide metabolism R-HSA-9735804 7.968679e-01 0.099 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.968679e-01 0.099 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.968679e-01 0.099 0 0
Processing of SMDT1 R-HSA-8949664 7.968679e-01 0.099 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.968679e-01 0.099 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.968679e-01 0.099 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.968679e-01 0.099 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.968679e-01 0.099 0 0
Vesicle-mediated transport R-HSA-5653656 7.972840e-01 0.098 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.009539e-01 0.096 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.009539e-01 0.096 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.009539e-01 0.096 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.009539e-01 0.096 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.009539e-01 0.096 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.009539e-01 0.096 0 0
TRP channels R-HSA-3295583 8.009539e-01 0.096 0 0
Insulin receptor signalling cascade R-HSA-74751 8.032831e-01 0.095 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.033664e-01 0.095 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.043865e-01 0.095 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.043865e-01 0.095 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.062911e-01 0.094 0 0
Translation of Structural Proteins R-HSA-9694635 8.062911e-01 0.094 1 0
SARS-CoV-2 Infection R-HSA-9694516 8.072487e-01 0.093 1 0
ER-Phagosome pathway R-HSA-1236974 8.102584e-01 0.091 0 0
Co-inhibition by PD-1 R-HSA-389948 8.126801e-01 0.090 0 0
SARS-CoV Infections R-HSA-9679506 8.143295e-01 0.089 1 0
Packaging Of Telomere Ends R-HSA-171306 8.145360e-01 0.089 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.145360e-01 0.089 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.145360e-01 0.089 0 0
PCP/CE pathway R-HSA-4086400 8.148419e-01 0.089 0 0
Signal regulatory protein family interactions R-HSA-391160 8.150574e-01 0.089 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.150574e-01 0.089 0 0
cGMP effects R-HSA-418457 8.150574e-01 0.089 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.150574e-01 0.089 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.150574e-01 0.089 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.150574e-01 0.089 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.150574e-01 0.089 0 0
Malate-aspartate shuttle R-HSA-9856872 8.150574e-01 0.089 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.150574e-01 0.089 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.150574e-01 0.089 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.157887e-01 0.088 0 0
HIV Transcription Elongation R-HSA-167169 8.157887e-01 0.088 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.157887e-01 0.088 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.161387e-01 0.088 0 0
Base Excision Repair R-HSA-73884 8.181536e-01 0.087 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.257907e-01 0.083 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.266214e-01 0.083 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.266214e-01 0.083 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.272830e-01 0.082 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.272830e-01 0.082 0 0
Pyrimidine salvage R-HSA-73614 8.272830e-01 0.082 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.272830e-01 0.082 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.302015e-01 0.081 0 0
G-protein mediated events R-HSA-112040 8.302015e-01 0.081 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.315474e-01 0.080 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.315474e-01 0.080 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.316192e-01 0.080 0 0
Erythropoietin activates RAS R-HSA-9027284 8.316192e-01 0.080 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.316192e-01 0.080 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.316192e-01 0.080 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.316192e-01 0.080 0 0
Signaling by Activin R-HSA-1502540 8.316192e-01 0.080 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.316192e-01 0.080 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.316192e-01 0.080 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.316192e-01 0.080 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.316192e-01 0.080 0 0
DNA Damage Reversal R-HSA-73942 8.316192e-01 0.080 0 0
Translation of Structural Proteins R-HSA-9683701 8.369039e-01 0.077 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.384800e-01 0.077 0 0
Platelet calcium homeostasis R-HSA-418360 8.392353e-01 0.076 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.392353e-01 0.076 0 0
Glucagon-type ligand receptors R-HSA-420092 8.392353e-01 0.076 0 0
Protein folding R-HSA-391251 8.403064e-01 0.076 0 0
G alpha (z) signalling events R-HSA-418597 8.405244e-01 0.075 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.456752e-01 0.073 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.466558e-01 0.072 0 0
Activation of GABAB receptors R-HSA-991365 8.466558e-01 0.072 0 0
GABA B receptor activation R-HSA-977444 8.466558e-01 0.072 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.466558e-01 0.072 0 0
Depyrimidination R-HSA-73928 8.466558e-01 0.072 0 0
Ca-dependent events R-HSA-111996 8.466558e-01 0.072 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.466987e-01 0.072 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.466987e-01 0.072 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.466987e-01 0.072 0 0
Killing mechanisms R-HSA-9664420 8.466987e-01 0.072 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.466987e-01 0.072 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.466987e-01 0.072 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.466987e-01 0.072 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.466987e-01 0.072 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.466987e-01 0.072 0 0
Attachment and Entry R-HSA-9678110 8.466987e-01 0.072 0 0
Atorvastatin ADME R-HSA-9754706 8.466987e-01 0.072 0 0
Negative regulation of FLT3 R-HSA-9706369 8.466987e-01 0.072 0 0
Differentiation of T cells R-HSA-9945266 8.466987e-01 0.072 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.466987e-01 0.072 0 0
Virus Assembly and Release R-HSA-168268 8.466987e-01 0.072 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.468663e-01 0.072 0 0
Integration of energy metabolism R-HSA-163685 8.468663e-01 0.072 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.491773e-01 0.071 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.491773e-01 0.071 0 0
Generic Transcription Pathway R-HSA-212436 8.492546e-01 0.071 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.504331e-01 0.070 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.532058e-01 0.069 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.538398e-01 0.069 0 0
Interleukin-17 signaling R-HSA-448424 8.540426e-01 0.069 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.558968e-01 0.068 0 0
L1CAM interactions R-HSA-373760 8.575947e-01 0.067 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.604285e-01 0.065 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.604285e-01 0.065 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.604285e-01 0.065 0 0
Passive transport by Aquaporins R-HSA-432047 8.604285e-01 0.065 0 0
Coenzyme A biosynthesis R-HSA-196783 8.604285e-01 0.065 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.604285e-01 0.065 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.604285e-01 0.065 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.609156e-01 0.065 0 0
Cargo concentration in the ER R-HSA-5694530 8.609156e-01 0.065 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.609156e-01 0.065 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.613434e-01 0.065 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.632459e-01 0.064 0 0
Rab regulation of trafficking R-HSA-9007101 8.632727e-01 0.064 0 0
Glucose metabolism R-HSA-70326 8.632727e-01 0.064 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.660366e-01 0.062 0 0
Neutrophil degranulation R-HSA-6798695 8.671285e-01 0.062 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.707211e-01 0.060 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.723812e-01 0.059 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.729255e-01 0.059 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.729295e-01 0.059 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.729295e-01 0.059 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.729295e-01 0.059 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.729295e-01 0.059 0 0
Glycogen storage diseases R-HSA-3229121 8.729295e-01 0.059 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.729295e-01 0.059 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.729295e-01 0.059 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.729295e-01 0.059 0 0
Ca2+ pathway R-HSA-4086398 8.750274e-01 0.058 0 0
Reproduction R-HSA-1474165 8.757721e-01 0.058 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.781129e-01 0.056 0 0
Metabolism of polyamines R-HSA-351202 8.795753e-01 0.056 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.798867e-01 0.056 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.798867e-01 0.056 0 0
Signaling by FGFR in disease R-HSA-1226099 8.814282e-01 0.055 0 0
Signaling by ERBB4 R-HSA-1236394 8.814282e-01 0.055 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.824302e-01 0.054 0 0
TCR signaling R-HSA-202403 8.835337e-01 0.054 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.843114e-01 0.053 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.843114e-01 0.053 0 0
Apoptotic factor-mediated response R-HSA-111471 8.843114e-01 0.053 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.843114e-01 0.053 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.843114e-01 0.053 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.843114e-01 0.053 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.843114e-01 0.053 0 0
Tie2 Signaling R-HSA-210993 8.843114e-01 0.053 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.843114e-01 0.053 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.843114e-01 0.053 0 0
MAPK family signaling cascades R-HSA-5683057 8.854247e-01 0.053 0 0
MAP kinase activation R-HSA-450294 8.863058e-01 0.052 0 0
Translation R-HSA-72766 8.869741e-01 0.052 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.875467e-01 0.052 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.881477e-01 0.052 0 0
Synthesis of PC R-HSA-1483191 8.881477e-01 0.052 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.884484e-01 0.051 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.884484e-01 0.051 0 0
FOXO-mediated transcription R-HSA-9614085 8.889347e-01 0.051 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.904227e-01 0.050 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.927055e-01 0.049 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.946745e-01 0.048 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.946745e-01 0.048 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.946745e-01 0.048 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.946745e-01 0.048 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.946745e-01 0.048 0 0
Regulation of signaling by CBL R-HSA-912631 8.946745e-01 0.048 0 0
Translesion Synthesis by POLH R-HSA-110320 8.946745e-01 0.048 0 0
The NLRP3 inflammasome R-HSA-844456 8.946745e-01 0.048 0 0
Other interleukin signaling R-HSA-449836 8.946745e-01 0.048 0 0
Specification of the neural plate border R-HSA-9834899 8.946745e-01 0.048 0 0
Diseases of hemostasis R-HSA-9671793 8.946745e-01 0.048 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.946745e-01 0.048 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.946745e-01 0.048 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.946745e-01 0.048 0 0
Intraflagellar transport R-HSA-5620924 8.951297e-01 0.048 0 0
Signal amplification R-HSA-392518 8.964407e-01 0.047 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.964407e-01 0.047 0 0
eNOS activation R-HSA-203615 8.964407e-01 0.047 0 0
Mitophagy R-HSA-5205647 8.964407e-01 0.047 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.973281e-01 0.047 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.981200e-01 0.047 0 0
Interleukin-1 signaling R-HSA-9020702 8.989373e-01 0.046 0 0
Downstream TCR signaling R-HSA-202424 9.008413e-01 0.045 0 0
Gap junction trafficking and regulation R-HSA-157858 9.017174e-01 0.045 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.041098e-01 0.044 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.041098e-01 0.044 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.041098e-01 0.044 0 0
Glycogen synthesis R-HSA-3322077 9.041098e-01 0.044 0 0
Signaling by NODAL R-HSA-1181150 9.041098e-01 0.044 0 0
Negative regulation of MET activity R-HSA-6807004 9.041098e-01 0.044 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.041098e-01 0.044 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.041098e-01 0.044 0 0
Pregnenolone biosynthesis R-HSA-196108 9.041098e-01 0.044 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.057429e-01 0.043 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.093780e-01 0.041 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.105482e-01 0.041 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.108491e-01 0.041 0 0
FLT3 signaling in disease R-HSA-9682385 9.108491e-01 0.041 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.109309e-01 0.041 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.127004e-01 0.040 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.127004e-01 0.040 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.127004e-01 0.040 0 0
ERK/MAPK targets R-HSA-198753 9.127004e-01 0.040 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.127004e-01 0.040 0 0
Basigin interactions R-HSA-210991 9.127004e-01 0.040 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.127004e-01 0.040 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.149273e-01 0.039 1 0
Voltage gated Potassium channels R-HSA-1296072 9.173274e-01 0.037 0 0
NCAM1 interactions R-HSA-419037 9.173274e-01 0.037 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.173274e-01 0.037 0 0
Collagen chain trimerization R-HSA-8948216 9.173274e-01 0.037 0 0
Selenoamino acid metabolism R-HSA-2408522 9.184649e-01 0.037 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.192958e-01 0.037 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.192958e-01 0.037 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.205219e-01 0.036 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.205219e-01 0.036 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.205219e-01 0.036 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.205219e-01 0.036 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.205219e-01 0.036 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.205219e-01 0.036 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.205219e-01 0.036 0 0
Serine metabolism R-HSA-977347 9.205219e-01 0.036 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.205219e-01 0.036 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.205219e-01 0.036 0 0
Attachment and Entry R-HSA-9694614 9.205219e-01 0.036 0 0
Ribavirin ADME R-HSA-9755088 9.205219e-01 0.036 0 0
MET promotes cell motility R-HSA-8875878 9.233611e-01 0.035 0 0
Purine salvage R-HSA-74217 9.233611e-01 0.035 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.233611e-01 0.035 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.244849e-01 0.034 0 0
Transcription of the HIV genome R-HSA-167172 9.248450e-01 0.034 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.274042e-01 0.033 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.276430e-01 0.033 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.276430e-01 0.033 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.276430e-01 0.033 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.276430e-01 0.033 0 0
Ethanol oxidation R-HSA-71384 9.276430e-01 0.033 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.276430e-01 0.033 0 0
LDL clearance R-HSA-8964038 9.276430e-01 0.033 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.276430e-01 0.033 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.289777e-01 0.032 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.289777e-01 0.032 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.316307e-01 0.031 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.341264e-01 0.030 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.341264e-01 0.030 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.341264e-01 0.030 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.341264e-01 0.030 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.341264e-01 0.030 0 0
Carnitine shuttle R-HSA-200425 9.341264e-01 0.030 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.341264e-01 0.030 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.341264e-01 0.030 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.341264e-01 0.030 0 0
Formation of the ureteric bud R-HSA-9830674 9.341264e-01 0.030 0 0
Interleukin-20 family signaling R-HSA-8854691 9.341264e-01 0.030 0 0
Diseases of Immune System R-HSA-5260271 9.342036e-01 0.030 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.342036e-01 0.030 0 0
Glycogen metabolism R-HSA-8982491 9.342036e-01 0.030 0 0
Generation of second messenger molecules R-HSA-202433 9.342036e-01 0.030 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.345482e-01 0.029 0 0
Potassium Channels R-HSA-1296071 9.345482e-01 0.029 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.360979e-01 0.029 0 0
Signaling by FGFR1 R-HSA-5654736 9.382698e-01 0.028 0 0
Maturation of spike protein R-HSA-9694548 9.390637e-01 0.027 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.390637e-01 0.027 0 0
Neddylation R-HSA-8951664 9.400127e-01 0.027 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.400293e-01 0.027 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.400293e-01 0.027 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.400293e-01 0.027 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.400293e-01 0.027 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.400293e-01 0.027 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.411991e-01 0.026 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.435815e-01 0.025 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.446872e-01 0.025 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.454036e-01 0.024 0 0
Long-term potentiation R-HSA-9620244 9.454036e-01 0.024 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.454036e-01 0.024 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.454036e-01 0.024 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.454036e-01 0.024 0 0
Laminin interactions R-HSA-3000157 9.454036e-01 0.024 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.461248e-01 0.024 0 0
Peroxisomal protein import R-HSA-9033241 9.496940e-01 0.022 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.496940e-01 0.022 0 0
Urea cycle R-HSA-70635 9.502965e-01 0.022 0 0
Abacavir ADME R-HSA-2161522 9.502965e-01 0.022 0 0
Sphingolipid catabolism R-HSA-9845614 9.502965e-01 0.022 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.502965e-01 0.022 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.516781e-01 0.022 0 0
Signaling by FGFR4 R-HSA-5654743 9.516781e-01 0.022 0 0
tRNA Aminoacylation R-HSA-379724 9.530418e-01 0.021 0 0
GABA receptor activation R-HSA-977443 9.530418e-01 0.021 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.530418e-01 0.021 0 0
Neurotransmitter release cycle R-HSA-112310 9.541672e-01 0.020 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.546530e-01 0.020 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.547512e-01 0.020 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.547512e-01 0.020 0 0
Triglyceride biosynthesis R-HSA-75109 9.547512e-01 0.020 0 0
Synthesis of PE R-HSA-1483213 9.547512e-01 0.020 0 0
Insulin processing R-HSA-264876 9.547512e-01 0.020 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.547512e-01 0.020 0 0
Gap junction trafficking R-HSA-190828 9.552979e-01 0.020 0 0
Amine ligand-binding receptors R-HSA-375280 9.552979e-01 0.020 0 0
Nucleotide salvage R-HSA-8956321 9.561804e-01 0.019 0 0
Signaling by FGFR3 R-HSA-5654741 9.586574e-01 0.018 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.588068e-01 0.018 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.588068e-01 0.018 0 0
Prednisone ADME R-HSA-9757110 9.588068e-01 0.018 0 0
Inflammasomes R-HSA-622312 9.588068e-01 0.018 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.588068e-01 0.018 0 0
Pyroptosis R-HSA-5620971 9.588068e-01 0.018 0 0
Mitochondrial protein import R-HSA-1268020 9.591217e-01 0.018 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.596504e-01 0.018 0 0
Integrin cell surface interactions R-HSA-216083 9.596504e-01 0.018 0 0
Signaling by Insulin receptor R-HSA-74752 9.616266e-01 0.017 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.617740e-01 0.017 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.621501e-01 0.017 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.621597e-01 0.017 0 0
mRNA Capping R-HSA-72086 9.624992e-01 0.017 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.624992e-01 0.017 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.624992e-01 0.017 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.624992e-01 0.017 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.624992e-01 0.017 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.624992e-01 0.017 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.624992e-01 0.017 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.624992e-01 0.017 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.624992e-01 0.017 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.624992e-01 0.017 0 0
HCMV Early Events R-HSA-9609690 9.644140e-01 0.016 0 0
Signaling by FGFR2 R-HSA-5654738 9.645055e-01 0.016 0 0
Hemostasis R-HSA-109582 9.645572e-01 0.016 0 0
tRNA processing R-HSA-72306 9.657842e-01 0.015 0 0
DAP12 signaling R-HSA-2424491 9.658608e-01 0.015 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.658608e-01 0.015 0 0
Neurotransmitter clearance R-HSA-112311 9.658608e-01 0.015 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.680761e-01 0.014 0 0
Stimuli-sensing channels R-HSA-2672351 9.680761e-01 0.014 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.688127e-01 0.014 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.689213e-01 0.014 0 0
Trafficking of AMPA receptors R-HSA-399719 9.689213e-01 0.014 0 0
Budding and maturation of HIV virion R-HSA-162588 9.689213e-01 0.014 0 0
Downstream signal transduction R-HSA-186763 9.689213e-01 0.014 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.691306e-01 0.014 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.696324e-01 0.013 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.698513e-01 0.013 0 0
Signaling by Interleukins R-HSA-449147 9.710244e-01 0.013 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.715354e-01 0.013 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.715354e-01 0.013 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.721278e-01 0.012 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.732190e-01 0.012 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.742186e-01 0.011 0 0
Interferon Signaling R-HSA-913531 9.742186e-01 0.011 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.742441e-01 0.011 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.742441e-01 0.011 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.742441e-01 0.011 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.742441e-01 0.011 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.742441e-01 0.011 0 0
Meiotic recombination R-HSA-912446 9.742587e-01 0.011 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.742587e-01 0.011 0 0
Complex IV assembly R-HSA-9864848 9.742587e-01 0.011 0 0
Signaling by FGFR R-HSA-190236 9.748993e-01 0.011 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.748993e-01 0.011 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.748993e-01 0.011 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.748993e-01 0.011 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.760025e-01 0.011 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.760813e-01 0.011 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.765535e-01 0.010 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.765535e-01 0.010 0 0
Heme degradation R-HSA-189483 9.765535e-01 0.010 0 0
COPII-mediated vesicle transport R-HSA-204005 9.767901e-01 0.010 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.775392e-01 0.010 0 0
Metabolism of cofactors R-HSA-8978934 9.784010e-01 0.009 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.786559e-01 0.009 0 0
Gap junction assembly R-HSA-190861 9.786559e-01 0.009 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.786559e-01 0.009 0 0
RA biosynthesis pathway R-HSA-5365859 9.786559e-01 0.009 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.786559e-01 0.009 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.786559e-01 0.009 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.787279e-01 0.009 0 0
Protein localization R-HSA-9609507 9.788050e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.799051e-01 0.009 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.805699e-01 0.009 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.805699e-01 0.009 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.813088e-01 0.008 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.823123e-01 0.008 0 0
Triglyceride catabolism R-HSA-163560 9.823123e-01 0.008 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.823123e-01 0.008 0 0
TNF signaling R-HSA-75893 9.827577e-01 0.008 0 0
HCMV Late Events R-HSA-9610379 9.827918e-01 0.008 0 0
G alpha (s) signalling events R-HSA-418555 9.833861e-01 0.007 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.833861e-01 0.007 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.836741e-01 0.007 0 0
RSV-host interactions R-HSA-9833110 9.837906e-01 0.007 0 0
Iron uptake and transport R-HSA-917937 9.838403e-01 0.007 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.838986e-01 0.007 0 0
Cardiac conduction R-HSA-5576891 9.840366e-01 0.007 0 0
Cellular response to chemical stress R-HSA-9711123 9.846087e-01 0.007 0 0
Viral Infection Pathways R-HSA-9824446 9.847453e-01 0.007 1 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.851233e-01 0.007 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.851233e-01 0.007 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.853427e-01 0.006 0 0
Triglyceride metabolism R-HSA-8979227 9.864733e-01 0.006 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.866574e-01 0.006 0 0
Pentose phosphate pathway R-HSA-71336 9.866574e-01 0.006 0 0
Cholesterol biosynthesis R-HSA-191273 9.870313e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.875289e-01 0.005 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.875977e-01 0.005 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.875977e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.877553e-01 0.005 0 0
Neuronal System R-HSA-112316 9.877606e-01 0.005 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.878542e-01 0.005 0 0
Interleukin-2 family signaling R-HSA-451927 9.878542e-01 0.005 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.882511e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.885040e-01 0.005 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.885667e-01 0.005 0 0
Signaling by MET R-HSA-6806834 9.888122e-01 0.005 0 0
Signaling by PDGF R-HSA-186797 9.894047e-01 0.005 0 0
HCMV Infection R-HSA-9609646 9.897603e-01 0.004 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.899356e-01 0.004 0 0
HIV Transcription Initiation R-HSA-167161 9.899356e-01 0.004 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.899356e-01 0.004 0 0
Intra-Golgi traffic R-HSA-6811438 9.899356e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.899356e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.899356e-01 0.004 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.899356e-01 0.004 0 0
Complex I biogenesis R-HSA-6799198 9.902363e-01 0.004 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.902363e-01 0.004 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.908386e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.908386e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.910918e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.910918e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.910918e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.914169e-01 0.004 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.916605e-01 0.004 0 0
Signaling by SCF-KIT R-HSA-1433557 9.916605e-01 0.004 0 0
DAP12 interactions R-HSA-2172127 9.924088e-01 0.003 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.930900e-01 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.933124e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.933703e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.933966e-01 0.003 0 0
Regulated Necrosis R-HSA-5218859 9.935266e-01 0.003 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.937101e-01 0.003 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.937101e-01 0.003 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.937101e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.937101e-01 0.003 0 0
Recycling pathway of L1 R-HSA-437239 9.942745e-01 0.002 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.942745e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.947884e-01 0.002 0 0
Gluconeogenesis R-HSA-70263 9.947884e-01 0.002 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.948210e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.952561e-01 0.002 0 0
Purine catabolism R-HSA-74259 9.953521e-01 0.002 0 0
Transmission across Chemical Synapses R-HSA-112315 9.954602e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.957571e-01 0.002 0 0
Interleukin-1 family signaling R-HSA-446652 9.959501e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.960695e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.961058e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.963932e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.966385e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.966599e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.968658e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.968853e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.970337e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.971830e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.972124e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.972124e-01 0.001 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.972212e-01 0.001 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.973020e-01 0.001 0 0
Toll-like Receptor Cascades R-HSA-168898 9.975686e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.977223e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.977223e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.977648e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.977648e-01 0.001 0 0
Amyloid fiber formation R-HSA-977225 9.978103e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.988151e-01 0.001 0 0
Ion transport by P-type ATPases R-HSA-936837 9.988433e-01 0.001 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.988433e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.989285e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.990607e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.991184e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.991279e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.991279e-01 0.000 0 0
Kidney development R-HSA-9830369 9.991279e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.992445e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.992813e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.993023e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.993037e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.993425e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.994016e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994016e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.994940e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.995043e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.995258e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.995258e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.995319e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.995782e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.995894e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996006e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.996553e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.997111e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997404e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.997587e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998081e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998242e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998583e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998794e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999294e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999377e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999407e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999484e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999723e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999810e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999817e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999854e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999854e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999881e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999928e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999935e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999946e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999971e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999977e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999979e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999983e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999985e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999988e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999989e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999990e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999990e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999995e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999996e-01 0.000 1 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999996e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999998e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999998e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Immune System R-HSA-168256 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways