SGK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A4FU28	S140	Sugiyama	CTAGE9	AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
O00141	S252	Sugiyama	SGK1 SGK	SQGHIVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQ
O00141	S255	Sugiyama	SGK1 SGK	HIVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPYD
O00141	S397	Sugiyama	SGK1 SGK	sGPNDLRHFDPEFTEEPVPNsIGKsPDsVLVTAsVKEAAEA
O00141	S404	Sugiyama	SGK1 SGK	HFDPEFTEEPVPNsIGKsPDsVLVTAsVKEAAEAFLGFsYA
O00141	S410	Sugiyama	SGK1 SGK	TEEPVPNsIGKsPDsVLVTAsVKEAAEAFLGFsYAPPTDSF
O00141	S422	PSP	SGK1 SGK	PDsVLVTAsVKEAAEAFLGFsYAPPTDSFL___________
O00141	T254	Sugiyama	SGK1 SGK	GHIVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPY
O00141	T256	Sugiyama	SGK1 SGK	IVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPYDR
O00141	T260	Sugiyama	SGK1 SGK	DFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPYDRTVDW
O00141	Y263	Sugiyama	SGK1 SGK	LCKENIEHNsTtstFCGtPEyLAPEVLHKQPYDRTVDWWCL
O00213	S610	EPSD\|PSP	APBB1 FE65 RIR	LTILHQQTEAVLGECRVRFLsFLAVGRDVHTFAFIMAAGPA
O00468	S738	Sugiyama	AGRN AGRIN	CGSDGVTYSTECELKKARCEsQRGLYVAAQGACRGPTFAPL
O00512	S104	Sugiyama	BCL9	GLKNGAGNGAKGKGKRERsIsADsFDQRDPGtPNDDsDIKE
O14617	S658	Sugiyama	AP3D1 PRO0039	DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14618	S267	Sugiyama	CCS	DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14639	S452	Sugiyama	ABLIM1 ABLIM KIAA0059 LIMAB1	PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14686	S1331	SIGNOR\|PSP	KMT2D ALR MLL2 MLL4	RRRPRGGAHGGRGRGRARLKsTASSIETLVVADIDSSPSKE
O14920	S181	EPSD\|PSP	IKBKB IKKB	IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15111	S180	GPS6\|EPSD	CHUK IKKA TCF16	IHKIIDLGYAKDVDQGsLCTsFVGTLQYLAPELFENKPYTA
O15111	T23	GPS6	CHUK IKKA TCF16	RPPGLRPGAGGPWEMRERLGtGGFGNVCLYQHRELDLKIAI
O15530	S176	Sugiyama	PDPK1 PDK1	YFGLSYAKNGELLKYIRKIGsFDETCTRFYTAEIVSALEYL
O43175	T78	Sugiyama	PHGDH PGDH3	KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43318	S439	Sugiyama	MAP3K7 TAK1	GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss
O43524	S253	SIGNOR\|ELM\|iPTMNet\|EPSD	FOXO3 FKHRL1 FOXO3A	WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA
O43524	S315	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	PtSRssDELDAWTDFRsRTNsNAsTVsGRLSPIMAsTELDE
O43524	T32	SIGNOR\|ELM\|iPTMNet\|EPSD	FOXO3 FKHRL1 FOXO3A	sPLEVELDPEFEPQSRPRsCtWPLQRPELQAsPAKPSGETA
O43707	T69	Sugiyama	ACTN4	EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60271	T595	Sugiyama	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	NLKYNAPTSHVtPsVKKRsstLsQLPGDKSKAFDFLSEETE
O60343	S318	GPS6\|PSP	TBC1D4 AS160 KIAA0603	ERILEDsGFDEQQEFRsRCssVTGVQRRVHEGSQKSQPRRR
O60343	S341	PSP	TBC1D4 AS160 KIAA0603	GVQRRVHEGSQKSQPRRRHAsAPsHVQPSDSEKNRTMLFQV
O60343	S570	PSP	TBC1D4 AS160 KIAA0603	ssGRFKLDILKNKAKRsLtssLENIFSRGANRMRGRLGsVD
O60343	S588	GPS6\|PSP\|Sugiyama	TBC1D4 AS160 KIAA0603	tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60343	S666	PSP	TBC1D4 AS160 KIAA0603	PPsstKRKLNLQDGRAQGVRsPLLRQSssEQCSNLSSVRRM
O60343	S751	GPS6\|PSP	TBC1D4 AS160 KIAA0603	EIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRIS
O60343	T568	GPS6\|PSP	TBC1D4 AS160 KIAA0603	AtssGRFKLDILKNKAKRsLtssLENIFSRGANRMRGRLGs
O60343	T642	GPS6\|PSP	TBC1D4 AS160 KIAA0603	AWQTFPEEDSDSPQFRRRAHtFsHPPsstKRKLNLQDGRAQ
O60716	Y865	Sugiyama	CTNND1 KIAA0384	KKsDFQVNLNNAsRsQssHsyDDstLPLIDRNQKsDKKPDR
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841	S178	Sugiyama	EIF5B IF2 KIAA0741	NKKWDGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRK
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75534	S584	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O75665	S899	Sugiyama	OFD1 CXorf5	EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75717	S374	Sugiyama	WDHD1 AND1	INDDEDDEDLMMAsGRPRQRsHILEDDENsVDIsMLKtGss
O75937	S81	Sugiyama	DNAJC8 SPF31 HSPC315 HSPC331	VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O94763	S372	Sugiyama	URI1 C19orf2 NNX3 PPP1R19 RMP URI	KNTTLKFSEKKEEAKRKRKNstGsGHsAQELPTIRTPADIY
O95239	S801	Sugiyama	KIF4A KIF4	LKEKKESGENPPPKLRRRtFsLtEVRGQVsEsEDsItKQIE
O95243	S318	Sugiyama	MBD4 MED1	ETLSVTSEENSLVKKKERsLssGsNFCSEQKTSGIINKFCS
O95243	S319	Sugiyama	MBD4 MED1	TLSVTSEENSLVKKKERsLssGsNFCSEQKTSGIINKFCSA
O95602	T1373	Sugiyama	POLR1A	SIKKKNNKASAFRNVNTRRAtQRDLDNAGELGRSRGEQEGD
O95757	T637	Sugiyama	HSPA4L APG1 HSPH3 OSP94	RNDAKNAVEEyVyDFRDRLGtVYEKFITPEDLSKLSAVLED
O95785	S1094	Sugiyama	WIZ ZNF803	WYVNGsPIDTLREILKRRTQsRPGGPPNPPGPsPKALAKMM
O95835	S464	Sugiyama	LATS1 WARTS	SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491	S163	Sugiyama	PNP NP	GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04150	S203	SIGNOR	NR3C1 GRL	LYTTDQSTFDILQDLEFssGsPGKETNEsPWRSDLLIDENC
P04150	S211	SIGNOR	NR3C1 GRL	FDILQDLEFssGsPGKETNEsPWRSDLLIDENCLLsPLAGE
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S83	Sugiyama	HSPB1 HSP27 HSP28	IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05023	S519	Sugiyama	ATP1A1	sEPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQ
P05023	S520	Sugiyama	ATP1A1	EPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQN
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05787	S280	Sugiyama	KRT8 CYK8	IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07339	S37	Sugiyama	CTSD CPSD	PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07355	S184	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S315	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQL
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238	S307	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQL
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238	T85	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08758	T8	Sugiyama	ANXA5 ANX5 ENX2 PP4	_____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CAP2	T184	Sugiyama	POLR2M GRINL1A	PSSEASEHHPRHRVssQAEDtSssFDNLFIDRLQRITIADQ
P0CG41	S140	Sugiyama	CTAGE8	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P10412	S36	Sugiyama	H1-4 H1F4 HIST1H1E	EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10636	S214	GPS6\|SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	GDLHQEGPPLKGAGGKERPGsKEEVDEDRDVDESsPQDsPP
P11142	S340	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11274	S371	Sugiyama	BCR BCR1 D22S11	SRVsPsPTTyRMFRDKsRsPsQNsQQsFDSssPPtPQCHKR
P11717	S1951	Sugiyama	IGF2R MPRI	ADYDRDHEWGFCRHSNSYRTssIIFKCDEDEDIGRPQVFSE
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13798	S175	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	WSHSETHLLYVAEKKRPKAEsFFQTKALDVsAsDDEIARLK
P13798	S27	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	LsEPEEAAALyRGLSRQPALsAACLGPEVtTQyGGQyRTVH
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P14625	T519	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P14672	S274	GPS6\|SIGNOR\|EPSD\|PSP	SLC2A4 GLUT4	SGVLAELKDEKRKLERERPLsLLQLLGSRTHRQPLIIAVVL
P14866	S544	Sugiyama	HNRNPL HNRPL P/OKcl.14	LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15056	S365	GPS6\|ELM\|iPTMNet\|EPSD	BRAF BRAF1 RAFB1	PFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIRD
P16220	S119	PSP	CREB1	EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16402	S37	Sugiyama	H1-3 H1F3 HIST1H1D	KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403	S36	Sugiyama	H1-2 H1F2 HIST1H1C	EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544	S44	Sugiyama	ATF7 ATFA	LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17655	T464	Sugiyama	CAPN2 CANPL2	TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL
P17812	S573	Sugiyama	CTPS1 CTPS	HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17987	S374	Sugiyama	TCP1 CCT1 CCTA	ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18858	S901	Sugiyama	LIG1	DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20810	S366	Sugiyama	CAST	DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS
P21333	S2152	Sugiyama	FLNA FLN FLN1	VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21731	S331	Sugiyama	TBXA2R	FRRAVLRRLQPRLsTRPRsLsLQPQLtQRSGLQ________
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588	S311	Sugiyama	EIF4B	YRGGGDRYEDRYDRRDDRsWssRDDysRDDYRRDDRGPPQR
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25789	S7	Sugiyama	PSMA4 HC9 PSC9	______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P25963	S32	EPSD\|PSP	NFKBIA IKBA MAD3 NFKBI	AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27816	T828	Sugiyama	MAP4	AKtttAAAVAstGPssRsPstLLPKKPTAIKTEGKPAEVKK
P28482	S29	GPS6\|SIGNOR\|EPSD\|PSP	MAPK1 ERK2 PRKM1 PRKM2	AGPEMVRGQVFDVGPRYTNLsYIGEGAYGMVCSAYDNVNKV
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30044	S182	Sugiyama	PRDX5 ACR1 SBBI10	DLLLDDsLVsIFGNRRLKRFsMVVQDGIVKALNVEPDGTGL
P30086	S54	Sugiyama	PEBP1 PBP PEBP	VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30086	T51	Sugiyama	PEBP1 PBP PEBP	GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30626	T170	Sugiyama	SRI	tNGKItFDDyIACCVKLRALtDSFRRRDTAQQGVVNFPYDD
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35269	T154	Sugiyama	GTF2F1 RAP74	AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269	T156	Sugiyama	GTF2F1 RAP74	EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42858	S419	SIGNOR\|EPSD\|PSP	HTT HD IT15	GGIGQLtAAKEEsGGRsRsGsIVELIAGGGssCsPVLsRKQ
P43003	T482	SIGNOR\|iPTMNet\|EPSD	SLC1A3 EAAT1 GLAST GLAST1	TDDITLIIAVDWFLDRLRTTtNVLGDSLGAGIVEHLSRHEL
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S234	Sugiyama	MATR3 KIAA0723	yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P45974	S783	Sugiyama	USP5 ISOT	IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P45985	S80	EPSD\|PSP	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	tLNPNPtGVQNPHIERLRTHsIEsSGKLKIsPEQHWDFtAE
P46527	T157	SIGNOR\|EPSD\|PSP	CDKN1B KIP1 p27	PsDsQTGLAEQCAGIRKRPAtDDSSTQNKRANRTEENVsDG
P46527	T198	SIGNOR\|EPSD\|PSP	CDKN1B KIP1 p27	sPNAGSVEQtPKKPGLRRRQt____________________
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P48048	S44	GPS6\|ELM\|EPSD	KCNJ1 ROMK1	LRKWVVTRFFGHSRQRARLVsKDGRCNIEFGNVEAQSRFIF
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48764	S663	GPS6\|EPSD	SLC9A3 NHE3	TEDEKQDREIFHRTMRKRLEsFKSTKLGLNQNKKAAKLYKR
P49327	T1999	Sugiyama	FASN FAS	LLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFVVF
P49419	S84	Sugiyama	ALDH7A1 ATQ1	EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49753	T118	Sugiyama	ACOT2 PTE2 PTE2A	ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
P49753	Y114	Sugiyama	ACOT2 PTE2 PTE2A	VTLRASLRDEKGALFQAHARyRADtLGELDLERAPALGGSF
P49792	T3217	Sugiyama	RANBP2 NUP358	DTVKKIESFGsPKGSVCRRItITECGQI_____________
P49815	S1130	SIGNOR\|PSP	TSC2 TSC4	AKLESQAGQQVSRGARDRVRsMsGGHGLRVGALDVPASQFL
P49815	S1132	SIGNOR\|PSP	TSC2 TSC4	LESQAGQQVSRGARDRVRsMsGGHGLRVGALDVPASQFLGs
P49815	S1798	PSP	TSC2 TSC4	AQTPAEPTPGyEVGQRKRLIssVEDFTEFV___________
P49815	S939	PSP	TSC2 TSC4	NVLLsFDDtPEKDsFRARsTsLNERPKSLRIARPPKQGLNN
P49815	S981	PSP	TSC2 TSC4	PPVKEFKESSAAEAFRCRsIsVsEHVVRSRIQTSLTsAsLG
P49815	T1462	PSP	TSC2 TSC4	EGPLPsssPRsPsGLRPRGYtIsDsAPsRRGKRVERDALKS
P49840	S21	iPTMNet\|EPSD	GSK3A	MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841	S21	ELM	GSK3B	MSGRPRttsFAEsCKPVQQPsAFGsMKVSRDKDGSKVTTVV
P49841	S9	PSP	GSK3B	____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P49841	Y216	PSP	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50395	S427	Sugiyama	GDI2 RABGDIB	ttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED__
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51946	T12	Sugiyama	CCNH	_________MYHNsSQKRHWtFSsEEQLARLRADANRKFRC
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P53365	S260	Sugiyama	ARFIP2 POR1	TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53602	S231	Sugiyama	MVD MPD	stVGMRASVETsPLLRFRAEsVVPARMAEMARCIRERDFPS
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55884	S119	Sugiyama	EIF3B EIF3S9	PPVPAQGEAPGEQARDERsDsRAQAVsEDAGGNEGRAAEAE
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942	T28	Sugiyama	FKBP1A FKBP1 FKBP12	IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363	Y451	Sugiyama	TUBA1B	DyEEVGVDsVEGEGEEEGEEy____________________
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00587	S192	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q00987	S166	GPS6\|EPSD\|PSP	MDM2	KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02952	S627	Sugiyama	AKAP12 AKAP250	VtPWAsFKKMVtPKKRVRRPsEsDKEDELDKVKsAtLsstE
Q04917	S145	Sugiyama	YWHAH YWHA1	KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q05682	T546	Sugiyama	CALD1 CAD CDM	GAPQVEAGKRLEELRRRRGEtESEEFEKLKQKQQEAALELE
Q06124	S134	Sugiyama	PTPN11 PTP2C SHPTP2	HGHLSGKEAEKLLTEKGKHGsFLVREsQsHPGDFVLSVRTG
Q07866	S524	Sugiyama	KLC1 KLC KNS2	QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q09161	S22	Sugiyama	NCBP1 CBP80 NCBP	SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q12778	S256	GPS6\|ELM	FOXO1 FKHR FOXO1A	WWMLNPEGGKSGKsPRRRAAsMDNNSKFAKSRSRAAKKKAs
Q12778	S319	ELM	FOXO1 FKHR FOXO1A	PGsHsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLG
Q12778	S322	GPS6	FOXO1 FKHR FOXO1A	HsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGD
Q12778	T24	GPS6\|SIGNOR\|ELM\|EPSD	FOXO1 FKHR FOXO1A	APQVVEIDPDFEPLPRPRsCtWPLPRPEFSQSNSATSSPAP
Q12931	T494	Sugiyama	TRAP1 HSP75 HSPC5	ALPsGQLtsLsEyASRMRAGtRNIyyLCAPNRHLAEHsPyy
Q12965	T936	Sugiyama	MYO1E MYO1C	LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q12965	Y941	Sugiyama	MYO1E MYO1C	GPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPPGy
Q12982	S114	Sugiyama	BNIP2 NIP2	EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13206	S831	Sugiyama	DDX10	DMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWDTL
Q13439	S41	Sugiyama	GOLGA4	APAQAssNsstPtRMRsRtssFtEQLDEGtPNRESGDTQSF
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13501	S28	Sugiyama	SQSTM1 ORCA OSIL	AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q13586	S620	Sugiyama	STIM1 GOK	sPsAPPGGsPHLDssRsHsPssPDPDtPsPVGDSRALQASR
Q14152	S1028	Sugiyama	EIF3A EIF3S10 KIAA0139	NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14204	S3082	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	LHVVFTMNPSSEGLKDRAAtsPALFNRCVLNWFGDWSTEAL
Q14204	S4368	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	MLEDEDDLAyAETEKKTRtDstsDGRPAWMRTLHTTASNWL
Q14432	S312	Sugiyama	PDE3A	sssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKRG
Q14671	S709	Sugiyama	PUM1 KIAA0099 PUMH1	LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14847	S99	Sugiyama	LASP1 MLN50	ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14978	S686	Sugiyama	NOLC1 KIAA0035 NS5ATP13	KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q15149	S4386	Sugiyama	PLEC PLEC1	ItEFADMLsGNAGGFRsRsssVGssssyPIsPAVsRtQLAs
Q15428	S153	Sugiyama	SF3A2 SAP62	LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA
Q15599	T102	Sugiyama	NHERF2 SLC9A3R2	QTRLLVVDQETDEELRRRQLtCTEEMAQRGLPPAHDPWEPK
Q15811	S315	Sugiyama	ITSN1 ITSN SH3D1A	LPPVLPPEYIPPSFRRVRsGsGIsVIsSTSVDQRLPEEPVL
Q15811	S318	Sugiyama	ITSN1 ITSN SH3D1A	VLPPEYIPPSFRRVRsGsGIsVIsSTSVDQRLPEEPVLEDE
Q15818	S91	Sugiyama	NPTX1	TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16637	S28	Sugiyama	SMN1 SMN SMNT; SMN2 SMNC	sGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVA
Q3KQU3	S112	Sugiyama	MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464	KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q53EL6	S71	Sugiyama	PDCD4 H731	NEARINAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtV
Q53EL6	S76	Sugiyama	PDCD4 H731	NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5JTD0	S545	Sugiyama	TJAP1 PILT TJP4	ssRPQRsPKRMGVHHLHRKDsLtQAQEQGNLLN________
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5SW79	S881	Sugiyama	CEP170 FAM68A KAB KIAA0470	sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5VT52	S1180	Sugiyama	RPRD2 KIAA0460 HSPC099	TGFKTAPYKERAPQFQEsVGsFRsNsFNstFEHHLPPsPLE
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5VV41	S208	Sugiyama	ARHGEF16 EPHEXIN4 NBR	HtRsPAKNKKTLGRKRGHKGsFKDDPQLyQEIQERGLNtsQ
Q6A1A2	S149	Sugiyama	PDPK2P PDPK2	YFGLSYAKNGELLKYIRKIGsFDETCTRFYTAEIVSALEYL
Q6R327	T1135	EPSD\|PSP	RICTOR KIAA1999	PKGGKLSSESKTSNRRIRtLtEPsVDFNHsDDFtPISTVQK
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18	S206	Sugiyama	AEBP2	DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q71RC2	S597	Sugiyama	LARP4 PP13296	QttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEPRKL
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36	Y451	Sugiyama	TUBA1A TUBA3	DyEEVGVDsVEGEGEEEGEEy____________________
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z4V5	S454	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q86T24	T606	PSP	ZBTB33 KAISO ZNF348	LHPCRSLQIRQYAYLSDRSStIPAMKDDGIGYKVDTGKEPP
Q86TX2	T56	Sugiyama	ACOT1 CTE1	ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
Q86TX2	Y52	Sugiyama	ACOT1 CTE1	VTLRASLRDEKGALFQAHARyRADtLGELDLERAPALGGSF
Q86UF2	S140	Sugiyama	CTAGE6 CTAGE6P	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86V48	S996	Sugiyama	LUZP1	RRVGPSSGDAPEPSSRRtQssLtVSEVLTRRNRVGDTITVA
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IX94	S140	Sugiyama	CTAGE4	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBJ7	T273	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	RGAsWIDtADGsANHRARVttRMGNtPDsAsDNLGFRCAAD
Q8ND56	T384	Sugiyama	LSM14A C19orf13 FAM61A RAP55 RAP55A	DKTKsFFDNIsCDDNRERRPtWAEERRLNAETFGIPLRPNR
Q8TD19	T333	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q92542	S437	SIGNOR\|EPSD\|PSP	NCSTN KIAA0253 UNQ1874/PRO4317	NQSQPLPPSSLQRFLRARNIsGVVLADHSGAFHNKYYQSIY
Q92558	T105	Sugiyama	WASF1 KIAA0269 SCAR1 WAVE1	PKEEELSLQDITMRKAFRsstIQDQQLFDRKTLPIPLQETy
Q92597	S330	GPS6\|SIGNOR\|ELM\|EPSD\|PSP\|Sugiyama	NDRG1 CAP43 DRG1 RTP	QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92597	S332	GPS6\|EPSD	NDRG1 CAP43 DRG1 RTP	MGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGTRs
Q92597	S364	GPS6\|EPSD\|Sugiyama	NDRG1 CAP43 DRG1 RTP	sHtSEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNs
Q92597	T328	GPS6\|ELM\|EPSD\|PSP	NDRG1 CAP43 DRG1 RTP	FVQGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSE
Q92597	T346	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NDRG1 CAP43 DRG1 RTP	sRtAsGssVtsLDGtRsRsHtSEGTRsRsHtsEGtRsRsHt
Q92597	T356	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NDRG1 CAP43 DRG1 RTP	sLDGtRsRsHtSEGTRsRsHtsEGtRsRsHtsEGAHLDItP
Q92597	T366	GPS6\|SIGNOR\|EPSD\|PSP\|Sugiyama	NDRG1 CAP43 DRG1 RTP	tSEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNsAG
Q92766	S1167	Sugiyama	RREB1 FINB	AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q969H0	S227	GPS6\|SIGNOR\|EPSD\|PSP	FBXW7 FBW7 FBX30 SEL10	TTFGDLRAANGQGQQRRRITsVQPPTGLQEWLKMFQSWSGP
Q96B36	T246	Sugiyama	AKT1S1 PRAS40	VLREAEDtQVFGDLPRPRLNtsDFQKLKRKY__________
Q96G46	T240	Sugiyama	DUS3L	KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96J92	S1190	EPSD\|PSP	WNK4 PRKWNK4	QPPPGIVAPAAMLSSRQRRLsKGSFPTSRRNsLQRSEPPGP
Q96J92	S1201	SIGNOR\|EPSD\|PSP	WNK4 PRKWNK4	MLSSRQRRLsKGSFPTSRRNsLQRSEPPGPGIMRRNsLsGs
Q96J92	S1217	EPSD\|PSP	WNK4 PRKWNK4	SRRNsLQRSEPPGPGIMRRNsLsGsSTGSQEQRASKGVTFA
Q96JJ3	S503	Sugiyama	ELMO2 CED12A KIAA1834	RALPSKPNSLDQFKSKLRsLsYsEILRLRQSERMSQDDFQS
Q96N67	S182	Sugiyama	DOCK7 KIAA1771	EAPDGNSyQDDQDDLKRRsMsIDDTPRGsWACSIFDLKNSL
Q96PU5	S342	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NEDD4L KIAA0439 NEDL3	NGEQFsSLIQREPssRLRsCsVtDAVAEQGHLPPPSAPAGR
Q96PU5	S428	iPTMNet\|EPSD	NEDD4L KIAA0439 NEDL3	NRTTTWTRPIMQLAEDGASGsATNSNNHLIEPQIRRPRsLs
Q96PU5	S448	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NEDD4L KIAA0439 NEDL3	sATNSNNHLIEPQIRRPRsLssPtVTLSAPLEGAKDsPVRR
Q96PU5	T367	ELM\|EPSD\|PSP	NEDD4L KIAA0439 NEDL3	VAEQGHLPPPSAPAGRARsstVtGGEEPTPsVAYVHttPGL
Q96PU5	T383	SIGNOR	NEDD4L KIAA0439 NEDL3	ARsstVtGGEEPTPsVAYVHttPGLPSGWEERKDAKGRTYY
Q96QF0	S165	Sugiyama	RAB3IP RABIN8	DGSDDIFGLsTDSLSRLRsPsVLEVREKGYERLKEELAKAQ
Q96RU3	S497	Sugiyama	FNBP1 FBP17 KIAA0554	AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q96RU3	Y500	Sugiyama	FNBP1 FBP17 KIAA0554	AEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREsPDG
Q96T58	S1268	Sugiyama	SPEN KIAA0929 MINT SHARP	SRQISEDsERtGGsPsVRHGsFHEDEDPIGsPRLLSVKGsP
Q99584	S32	Sugiyama	S100A13	SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99613	T880	Sugiyama	EIF3C EIF3S8	AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q99759	S166	GPS6\|SIGNOR\|ELM\|EPSD	MAP3K3 MAPKKK3 MEKK3	QsAGDINtIyQPPEPRsRHLsVssQNPGRssPPPGYVPERQ
Q99759	S337	GPS6\|SIGNOR\|ELM\|EPSD	MAP3K3 MAPKKK3 MEKK3	tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BPZ7	S510	Sugiyama	MAPKAP1 MIP1 SIN1	ASTARADYFAQKQRKLNRRtsFsFQKEKKSGQQ________
Q9BRF8	T17	Sugiyama	CPPED1 CSTP1	____MSAAEAGGVFHRARGRtLAAFPAEKESEWKGPFYFIL
Q9BUB5	S352	SIGNOR	MKNK1 MNK1	KYEFPDKDWAHISSEAKDLIsKLLVRDAKQRLSAAQVLQHP
Q9BW19	T157	Sugiyama	KIFC1 HSET KNSL2	WDLKGQLCDLNAELKRCRERtQtLDQENQQLQDQLRDAQQQ
Q9BXF6	S395	Sugiyama	RAB11FIP5 GAF1 KIAA0857 RIP11	FsEEGPRSTDDTWPRGsRsNsssEAVLGQEELSAQAKVLAP
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9H2C0	S272	Sugiyama	GAN GAN1 KLHL16	PLSQPQQGEAMLANFKPRGysECIVTVGGEERVSRKPTAAM
Q9H2G2	S344	Sugiyama	SLK KIAA0204 STK2	EEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACILEsVS
Q9H3H1	S431	Sugiyama	TRIT1 IPT MOD5	AAHIKSKSHLNQLKKRRRLDsDAVNTIEsQsVsPDHNKEPK
Q9H4A3	T2245	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	TVNSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLS
Q9H4A3	T60	EPSD\|PSP	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GAAAADAVtGRtEEyRRRRHtMDKDSRGAAAtTtTTEHRFF
Q9H6H4	S152	Sugiyama	REEP4 C8orf20 PP432	AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H7D7	S123	Sugiyama	WDR26 CDW2 MIP2 PRO0852	SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9H7E2	S365	Sugiyama	TDRD3	sVLEGSGLPRNRGsERPSTssVsEVWAEDRIKCDRPYSRYD
Q9HA77	S548	Sugiyama	CARS2 OK/SW-cl.10	TLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG____
Q9NPD8	S184	Sugiyama	UBE2T HSPC150 PIG50	DNLPEAGDsRVHNstQKRKAsQLVGIEKKFHPDV_______
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQY0	S248	Sugiyama	BIN3	HSDEQRERENEAKLSELRALsIVADD_______________
Q9NRA8	S353	Sugiyama	EIF4ENIF1	SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL
Q9NUU7	T467	Sugiyama	DDX19A DDX19L	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NVN8	S513	Sugiyama	GNL3L	PNRHQMGWAKRNVDHRPKsNsMVDVCsVDRRSVLQRIMETD
Q9NZN5	T1293	Sugiyama	ARHGEF12 KIAA0382 LARG	sVQEDWQHFPRyRtAsQGPQtDSVIQNSENIKAyHsGEGHM
Q9NZQ3	T251	Sugiyama	NCKIPSD AF3P21 SPIN90	SPSEPGSSCSPtPPPVPRRGtHTTVsQVQPPPSKASAPEPP
Q9P265	S203	Sugiyama	DIP2B KIAA1463	stsssASSTLSHGEVKGtsGsLADVFANtRIENFSAPPDVT
Q9UBP6	S27	Sugiyama	METTL1 C12orf1	NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2	S327	Sugiyama	NDRG3	KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2	S331	Sugiyama	NDRG3	QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2	S333	Sugiyama	NDRG3	MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S39	Sugiyama	ATP5IF1 ATPI ATPIF1	TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9ULD2	S199	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	GKsQsFHtAGSLPPTGRRsGstsSLSySTWTSSHSDKTHAR
Q9ULF5	T44	Sugiyama	SLC39A10 KIAA1265 ZIP10	HCHEEHDHGPEALHRQHRGMtELEPSKFSKQAAENEKKYYI
Q9ULL1	S615	Sugiyama	PLEKHG1 KIAA1209	STETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTRELQNSP
Q9UMR2	T468	Sugiyama	DDX19B DBP5 DDX19 TDBP	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UN36	S332	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NDRG2 KIAA1248 SYLD	QGMGYMASSCMTRLsRsRtAsLtsAAsVDGNRsRsRtLsQs
Q9UN36	S346	EPSD\|PSP	NDRG2 KIAA1248 SYLD	sRsRtAsLtsAAsVDGNRsRsRtLsQssEsGtLsSGPPGHT
Q9UN36	T330	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NDRG2 KIAA1248 SYLD	FLQGMGYMASSCMTRLsRsRtAsLtsAAsVDGNRsRsRtLs
Q9UN36	T348	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NDRG2 KIAA1248 SYLD	sRtAsLtsAAsVDGNRsRsRtLsQssEsGtLsSGPPGHTME
Q9UNH7	S316	Sugiyama	SNX6	LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35	S1539	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S992	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLsGs
Q9Y230	T419	Sugiyama	RUVBL2 INO80J TIP48 TIP49B CGI-46	LRYAIQLITAASLVCRKRKGtEVQVDDIKRVysLFLDEsRS
Q9Y266	T145	Sugiyama	NUDC	AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y2B0	S55	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2I7	S307	Sugiyama	PIKFYVE KIAA0981 PIP5K3	TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2I7	S318	EPSD\|PSP	PIKFYVE KIAA0981 PIP5K3	KsPARNRsAsItNLsLDRsGsPMVPSYEtsVsPQANRTYVR
Q9Y2V2	S52	GPS6\|ELM\|EPSD\|PSP\|Sugiyama	CARHSP1	sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y3S1	T2157	Sugiyama	WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13	GPQPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAA
Q9Y534	S58	GPS6	CSDC2 PIPPIN	GGVPPRDLPsPLPTKRTRTYsATARASAGPVFKGVCKQFSR
Q9Y6D5	S276	Sugiyama	ARFGEF2 ARFGEP2 BIG2	ARSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDV
Q9Y6D5	S277	Sugiyama	ARFGEF2 ARFGEP2 BIG2	RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle	R-HSA-1640170	2.102000e-09	8.677	0	0
Chromatin organization	R-HSA-4839726	2.655269e-09	8.576	0	0
Chromatin modifying enzymes	R-HSA-3247509	7.488057e-09	8.126	0	0
Signal Transduction	R-HSA-162582	8.028848e-09	8.095	1	0
Cell Cycle, Mitotic	R-HSA-69278	3.024482e-08	7.519	0	0
Cellular Senescence	R-HSA-2559583	6.006145e-08	7.221	0	0
NRAGE signals death through JNK	R-HSA-193648	2.853861e-07	6.545	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.403088e-07	6.267	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.700452e-07	6.244	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.220314e-07	6.085	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	8.875002e-07	6.052	0	0
Apoptotic execution phase	R-HSA-75153	8.977776e-07	6.047	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.082451e-06	5.966	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.843414e-06	5.734	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.781909e-06	5.749	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.200267e-06	5.658	0	0
Axon guidance	R-HSA-422475	2.771050e-06	5.557	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.419866e-06	5.466	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	9.756969e-06	5.011	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.081724e-05	4.966	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.286055e-05	4.891	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.281385e-05	4.892	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.563269e-05	4.806	0	0
Nervous system development	R-HSA-9675108	1.749576e-05	4.757	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.222941e-05	4.653	0	0
Regulation of TP53 Activity	R-HSA-5633007	3.357975e-05	4.474	1	0
HATs acetylate histones	R-HSA-3214847	3.576080e-05	4.447	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	3.576080e-05	4.447	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.733869e-05	4.428	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.959435e-05	4.402	0	0
Intracellular signaling by second messengers	R-HSA-9006925	4.555474e-05	4.341	1	0
Transcriptional Regulation by E2F6	R-HSA-8953750	5.035266e-05	4.298	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.051993e-05	4.297	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	6.192249e-05	4.208	0	0
G2/M DNA damage checkpoint	R-HSA-69473	8.500799e-05	4.071	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.093388e-04	3.961	0	0
Meiotic synapsis	R-HSA-1221632	1.460858e-04	3.835	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.460858e-04	3.835	0	0
Meiosis	R-HSA-1500620	1.508439e-04	3.821	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.681106e-04	3.774	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.733722e-04	3.761	0	0
Death Receptor Signaling	R-HSA-73887	1.731646e-04	3.762	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.834945e-04	3.736	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.896848e-04	3.722	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.941905e-04	3.712	0	0
Reproduction	R-HSA-1474165	1.946079e-04	3.711	0	0
G2/M Checkpoints	R-HSA-69481	2.068654e-04	3.684	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.207380e-04	3.656	0	0
Mitotic Prophase	R-HSA-68875	2.329909e-04	3.633	0	0
DNA Double Strand Break Response	R-HSA-5693606	2.387469e-04	3.622	0	0
Cell-Cell communication	R-HSA-1500931	2.411689e-04	3.618	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.459877e-04	3.609	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.837096e-04	3.547	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.775147e-04	3.557	0	0
M Phase	R-HSA-68886	3.014909e-04	3.521	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.317000e-04	3.479	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	3.319569e-04	3.479	0	0
DNA methylation	R-HSA-5334118	3.683737e-04	3.434	0	0
Signaling by Hippo	R-HSA-2028269	4.269550e-04	3.370	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.004045e-04	3.398	1	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.076421e-04	3.390	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.187261e-04	3.378	0	0
Cell junction organization	R-HSA-446728	4.179898e-04	3.379	0	0
Gene expression (Transcription)	R-HSA-74160	4.276616e-04	3.369	1	0
PRC2 methylates histones and DNA	R-HSA-212300	4.603901e-04	3.337	0	0
Generic Transcription Pathway	R-HSA-212436	5.408483e-04	3.267	1	0
Meiotic recombination	R-HSA-912446	5.446659e-04	3.264	0	0
Packaging Of Telomere Ends	R-HSA-171306	5.851319e-04	3.233	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.851319e-04	3.233	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.313411e-04	3.200	0	0
Epigenetic regulation of gene expression	R-HSA-212165	6.767366e-04	3.170	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	6.891380e-04	3.162	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.223680e-04	3.141	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	8.485819e-04	3.071	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.705711e-04	3.060	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.179595e-04	3.037	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	9.380133e-04	3.028	0	0
Signaling by VEGF	R-HSA-194138	9.914022e-04	3.004	0	0
Regulation of endogenous retroelements	R-HSA-9842860	9.914621e-04	3.004	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.038921e-03	2.983	1	0
Post NMDA receptor activation events	R-HSA-438064	1.079482e-03	2.967	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.086139e-03	2.964	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.086139e-03	2.964	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.106268e-03	2.956	0	0
Activation of RAC1	R-HSA-428540	1.127042e-03	2.948	0	0
Homology Directed Repair	R-HSA-5693538	1.143868e-03	2.942	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.239321e-03	2.907	0	0
PIP3 activates AKT signaling	R-HSA-1257604	1.195803e-03	2.922	1	1
HDACs deacetylate histones	R-HSA-3214815	1.245119e-03	2.905	0	0
Diseases of programmed cell death	R-HSA-9645723	1.260644e-03	2.899	0	0
Specification of primordial germ cells	R-HSA-9827857	1.444997e-03	2.840	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.554501e-03	2.808	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.613314e-03	2.792	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.742133e-03	2.759	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.752504e-03	2.756	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.508461e-03	2.601	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.390007e-03	2.622	1	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.559359e-03	2.592	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.600529e-03	2.585	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.693015e-03	2.570	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.900047e-03	2.538	0	0
Rap1 signalling	R-HSA-392517	2.801803e-03	2.553	0	0
L1CAM interactions	R-HSA-373760	2.823263e-03	2.549	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.960677e-03	2.529	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.993069e-03	2.524	0	0
Amplification of signal from the kinetochores	R-HSA-141424	2.993069e-03	2.524	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.100085e-03	2.509	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.159159e-03	2.500	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.447940e-03	2.462	0	0
Co-stimulation by CD28	R-HSA-389356	3.481055e-03	2.458	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	3.424637e-03	2.465	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.640839e-03	2.439	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	3.640839e-03	2.439	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.668293e-03	2.436	0	0
Cleavage of the damaged purine	R-HSA-110331	3.668293e-03	2.436	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	4.383095e-03	2.358	0	0
Nucleosome assembly	R-HSA-774815	4.327816e-03	2.364	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.327816e-03	2.364	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	4.484539e-03	2.348	0	0
DAG and IP3 signaling	R-HSA-1489509	4.327816e-03	2.364	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.499519e-03	2.347	0	0
Depurination	R-HSA-73927	4.520630e-03	2.345	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	4.688911e-03	2.329	0	0
Regulation of TP53 Expression	R-HSA-6804754	4.839304e-03	2.315	0	0
Oncogenic MAPK signaling	R-HSA-6802957	4.872580e-03	2.312	0	0
Protein-protein interactions at synapses	R-HSA-6794362	4.872580e-03	2.312	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.299933e-03	2.276	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.545768e-03	2.256	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	5.385974e-03	2.269	0	0
Depyrimidination	R-HSA-73928	5.385974e-03	2.269	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	5.640401e-03	2.249	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.981282e-03	2.223	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	6.877738e-03	2.163	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	6.877738e-03	2.163	0	0
HDMs demethylate histones	R-HSA-3214842	6.879432e-03	2.162	0	0
Sema4D in semaphorin signaling	R-HSA-400685	6.879432e-03	2.162	0	0
RET signaling	R-HSA-8853659	6.885574e-03	2.162	0	0
NrCAM interactions	R-HSA-447038	6.877738e-03	2.163	0	0
Calmodulin induced events	R-HSA-111933	6.885574e-03	2.162	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.846557e-03	2.165	0	0
CaM pathway	R-HSA-111997	6.885574e-03	2.162	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.588839e-03	2.181	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.990765e-03	2.155	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	7.033292e-03	2.153	0	0
ESR-mediated signaling	R-HSA-8939211	7.070591e-03	2.151	0	0
Muscle contraction	R-HSA-397014	7.226939e-03	2.141	0	0
Signaling by ROBO receptors	R-HSA-376176	7.257920e-03	2.139	0	0
Mitotic Prometaphase	R-HSA-68877	7.266766e-03	2.139	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.425702e-03	2.129	0	0
AURKA Activation by TPX2	R-HSA-8854518	7.956015e-03	2.099	0	0
EPH-Ephrin signaling	R-HSA-2682334	8.561281e-03	2.067	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.423851e-03	2.074	0	0
Rab regulation of trafficking	R-HSA-9007101	9.131999e-03	2.039	0	0
Assembly of the pre-replicative complex	R-HSA-68867	9.644078e-03	2.016	0	0
Semaphorin interactions	R-HSA-373755	9.847168e-03	2.007	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.029923e-02	1.987	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.047098e-02	1.980	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.047098e-02	1.980	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.085460e-02	1.964	0	0
Mitotic G2-G2/M phases	R-HSA-453274	1.096221e-02	1.960	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.172738e-02	1.931	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.172738e-02	1.931	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.120732e-02	1.950	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	1.120732e-02	1.950	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	1.120732e-02	1.950	0	0
Type I hemidesmosome assembly	R-HSA-446107	1.120732e-02	1.950	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.209973e-02	1.917	0	0
MTOR signalling	R-HSA-165159	1.151791e-02	1.939	0	0
Adherens junctions interactions	R-HSA-418990	1.144815e-02	1.941	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.263315e-02	1.898	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.302329e-02	1.885	0	0
G0 and Early G1	R-HSA-1538133	1.308549e-02	1.883	0	0
Cell-cell junction organization	R-HSA-421270	1.333773e-02	1.875	0	0
Signaling by WNT	R-HSA-195721	1.347554e-02	1.870	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.354927e-02	1.868	0	0
Defective pyroptosis	R-HSA-9710421	1.361544e-02	1.866	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.386815e-02	1.858	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.386815e-02	1.858	0	0
Neurexins and neuroligins	R-HSA-6794361	1.402504e-02	1.853	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.446803e-02	1.840	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.599937e-02	1.796	0	0
Netrin-1 signaling	R-HSA-373752	1.599937e-02	1.796	0	0
DNA Replication Pre-Initiation	R-HSA-69002	1.446803e-02	1.840	0	0
Regulation of TP53 Degradation	R-HSA-6804757	1.514400e-02	1.820	1	1
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.511112e-02	1.821	0	0
Activation of ATR in response to replication stress	R-HSA-176187	1.582905e-02	1.801	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.608911e-02	1.793	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.849491e-02	1.733	0	0
CREB phosphorylation	R-HSA-199920	1.849491e-02	1.733	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.647408e-02	1.783	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.666381e-02	1.778	0	0
Ephrin signaling	R-HSA-3928664	1.666381e-02	1.778	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.693449e-02	1.771	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.680372e-02	1.775	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.680372e-02	1.775	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.802104e-02	1.744	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.701396e-02	1.769	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.837083e-02	1.736	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.837083e-02	1.736	0	0
Polo-like kinase mediated events	R-HSA-156711	1.666381e-02	1.778	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.748908e-02	1.757	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.774228e-02	1.751	1	0
FLT3 Signaling	R-HSA-9607240	1.701396e-02	1.769	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.774228e-02	1.751	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.873743e-02	1.727	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.892348e-02	1.723	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.892348e-02	1.723	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.987424e-02	1.702	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.003625e-02	1.698	0	0
G2/M Transition	R-HSA-69275	2.046981e-02	1.689	0	0
TRP channels	R-HSA-3295583	2.060878e-02	1.686	0	0
Specification of the neural plate border	R-HSA-9834899	2.119366e-02	1.674	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.170466e-02	1.663	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.170466e-02	1.663	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.170466e-02	1.663	0	0
Kinesins	R-HSA-983189	2.267011e-02	1.645	0	0
RAB geranylgeranylation	R-HSA-8873719	2.267011e-02	1.645	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.564101e-02	1.591	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.564101e-02	1.591	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.654679e-02	1.576	0	0
Centrosome maturation	R-HSA-380287	2.530971e-02	1.597	0	0
Ion homeostasis	R-HSA-5578775	2.458606e-02	1.609	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.323754e-02	1.634	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.564101e-02	1.591	0	0
PLC beta mediated events	R-HSA-112043	2.574424e-02	1.589	0	0
Ca-dependent events	R-HSA-111996	2.332875e-02	1.632	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.501301e-02	1.602	0	0
Regulation of PTEN localization	R-HSA-8948747	2.743023e-02	1.562	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.979940e-02	1.526	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.982122e-02	1.525	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.014129e-02	1.521	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.014129e-02	1.521	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.014129e-02	1.521	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.014129e-02	1.521	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.014129e-02	1.521	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.085123e-02	1.511	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.085123e-02	1.511	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.156947e-02	1.501	0	0
Neurodegenerative Diseases	R-HSA-8863678	3.156947e-02	1.501	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.164968e-02	1.500	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.274619e-02	1.485	1	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.278910e-02	1.484	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.310326e-02	1.480	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.332091e-02	1.477	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.340241e-02	1.476	0	0
Chromosome Maintenance	R-HSA-73886	3.340241e-02	1.476	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.450985e-02	1.462	0	0
S Phase	R-HSA-69242	3.466815e-02	1.460	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.997928e-02	1.398	0	0
Striated Muscle Contraction	R-HSA-390522	3.932942e-02	1.405	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.099653e-02	1.387	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	4.099653e-02	1.387	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.099653e-02	1.387	0	0
DARPP-32 events	R-HSA-180024	3.580106e-02	1.446	0	0
Signaling by RAS mutants	R-HSA-6802949	4.099653e-02	1.387	0	0
Long-term potentiation	R-HSA-9620244	3.798557e-02	1.420	0	0
DNA Repair	R-HSA-73894	3.864237e-02	1.413	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.588807e-02	1.445	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.125888e-02	1.384	0	0
Signaling by Interleukins	R-HSA-449147	4.155692e-02	1.381	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	4.156948e-02	1.381	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.182933e-02	1.379	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.182933e-02	1.379	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.203401e-02	1.376	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.224425e-02	1.374	1	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.224913e-02	1.374	0	0
Activation of the pre-replicative complex	R-HSA-68962	4.226742e-02	1.374	0	0
Interleukin-37 signaling	R-HSA-9008059	4.226742e-02	1.374	0	0
DCC mediated attractive signaling	R-HSA-418885	4.239615e-02	1.373	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.239615e-02	1.373	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.239615e-02	1.373	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.373324e-02	1.359	0	0
Telomere Maintenance	R-HSA-157579	4.376417e-02	1.359	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	4.456066e-02	1.351	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	4.456066e-02	1.351	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	4.456066e-02	1.351	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	4.456066e-02	1.351	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	4.456066e-02	1.351	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	4.456066e-02	1.351	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	5.222126e-02	1.282	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.635641e-02	1.334	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	4.635641e-02	1.334	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	4.635641e-02	1.334	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	5.246262e-02	1.280	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	5.246262e-02	1.280	0	0
Germ layer formation at gastrulation	R-HSA-9754189	5.083807e-02	1.294	0	0
RAF activation	R-HSA-5673000	4.576813e-02	1.339	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	4.818065e-02	1.317	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	4.948211e-02	1.306	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.404749e-02	1.356	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.635641e-02	1.334	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.222126e-02	1.282	0	0
G-protein mediated events	R-HSA-112040	5.116300e-02	1.291	0	0
Apoptosis	R-HSA-109581	4.494045e-02	1.347	0	0
Recycling pathway of L1	R-HSA-437239	4.660320e-02	1.332	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.237760e-02	1.281	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	4.718868e-02	1.326	0	0
Ub-specific processing proteases	R-HSA-5689880	4.972716e-02	1.303	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.635641e-02	1.334	0	0
NGF-stimulated transcription	R-HSA-9031628	5.272767e-02	1.278	1	1
Unwinding of DNA	R-HSA-176974	5.246262e-02	1.280	0	0
TBC/RABGAPs	R-HSA-8854214	5.090084e-02	1.293	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.741229e-02	1.324	0	0
Signaling by ALK in cancer	R-HSA-9700206	4.741229e-02	1.324	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.293390e-02	1.276	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.385840e-02	1.269	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.416491e-02	1.266	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	5.527947e-02	1.257	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.669997e-02	1.246	0	0
RNA Polymerase I Transcription	R-HSA-73864	5.731870e-02	1.242	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.739394e-02	1.241	0	0
Neuronal System	R-HSA-112316	5.965717e-02	1.224	0	0
Nephrin family interactions	R-HSA-373753	6.134411e-02	1.212	0	0
Membrane Trafficking	R-HSA-199991	6.223250e-02	1.206	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.286373e-02	1.202	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	6.635506e-02	1.178	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.636839e-02	1.178	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	6.778005e-02	1.169	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	6.778005e-02	1.169	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	6.834772e-02	1.165	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	6.870708e-02	1.163	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.870708e-02	1.163	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	6.870708e-02	1.163	0	0
mRNA Splicing	R-HSA-72172	6.870755e-02	1.163	0	0
DNA Replication	R-HSA-69306	6.980229e-02	1.156	0	0
Signaling by NTRKs	R-HSA-166520	7.105486e-02	1.148	1	0
Signaling by RAF1 mutants	R-HSA-9656223	7.155969e-02	1.145	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	7.246020e-02	1.140	0	0
Base Excision Repair	R-HSA-73884	7.417706e-02	1.130	0	0
Opioid Signalling	R-HSA-111885	7.767646e-02	1.110	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	7.767646e-02	1.110	0	0
FOXO-mediated transcription	R-HSA-9614085	7.866026e-02	1.104	0	0
TGFBR3 expression	R-HSA-9839394	7.906960e-02	1.102	0	0
MTF1 activates gene expression	R-HSA-5660489	8.014151e-02	1.096	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	8.014151e-02	1.096	0	0
HCN channels	R-HSA-1296061	8.014151e-02	1.096	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	8.014151e-02	1.096	0	0
Dopamine receptors	R-HSA-390651	8.014151e-02	1.096	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	9.008631e-02	1.045	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	9.008631e-02	1.045	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	8.804094e-02	1.055	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	8.804094e-02	1.055	0	0
PKA activation	R-HSA-163615	9.364368e-02	1.029	0	0
PKA activation in glucagon signalling	R-HSA-164378	9.364368e-02	1.029	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.154408e-02	1.038	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.299594e-02	1.081	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	9.064617e-02	1.043	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.195852e-02	1.086	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	8.992107e-02	1.046	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	9.536484e-02	1.021	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.423576e-02	1.075	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	9.364368e-02	1.029	0	0
Cyclin D associated events in G1	R-HSA-69231	1.006030e-01	0.997	0	0
G1 Phase	R-HSA-69236	1.006030e-01	0.997	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.275245e-02	1.033	0	0
mTORC1-mediated signalling	R-HSA-166208	1.004771e-01	0.998	0	0
Programmed Cell Death	R-HSA-5357801	9.622445e-02	1.017	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.367701e-02	1.077	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	8.367701e-02	1.077	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	8.123291e-02	1.090	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.359874e-02	1.078	0	0
Regulation of KIT signaling	R-HSA-1433559	8.359874e-02	1.078	0	0
MECP2 regulates transcription factors	R-HSA-9022707	8.804094e-02	1.055	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	8.616081e-02	1.065	0	0
Sensory processing of sound	R-HSA-9659379	9.771097e-02	1.010	0	0
PI Metabolism	R-HSA-1483255	9.822270e-02	1.008	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	9.364368e-02	1.029	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.012817e-01	0.994	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.012817e-01	0.994	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.051071e-01	0.978	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.059181e-01	0.975	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.085005e-01	0.965	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.085005e-01	0.965	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.109515e-01	0.955	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.112066e-01	0.954	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.131586e-01	0.946	0	0
IRS activation	R-HSA-74713	1.131586e-01	0.946	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.131586e-01	0.946	0	0
G2 Phase	R-HSA-68911	1.131586e-01	0.946	0	0
Cellular responses to stimuli	R-HSA-8953897	1.131874e-01	0.946	0	0
Cardiac conduction	R-HSA-5576891	1.134142e-01	0.945	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.138521e-01	0.944	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.138521e-01	0.944	0	0
Co-stimulation by ICOS	R-HSA-9927354	1.138521e-01	0.944	0	0
Interleukin-12 signaling	R-HSA-9020591	1.162478e-01	0.935	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.203045e-01	0.920	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.207618e-01	0.918	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.207618e-01	0.918	0	0
G-protein beta:gamma signalling	R-HSA-397795	1.219751e-01	0.914	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.219751e-01	0.914	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.219751e-01	0.914	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.224015e-01	0.912	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.228232e-01	0.911	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.231576e-01	0.910	0	0
Mitotic Anaphase	R-HSA-68882	1.253038e-01	0.902	0	0
Deubiquitination	R-HSA-5688426	1.269057e-01	0.897	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.276910e-01	0.894	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.305016e-01	0.884	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.310706e-01	0.882	0	0
Heme signaling	R-HSA-9707616	1.314682e-01	0.881	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.318080e-01	0.880	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.318080e-01	0.880	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.318080e-01	0.880	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.318080e-01	0.880	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.318080e-01	0.880	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.318080e-01	0.880	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.318080e-01	0.880	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.331505e-01	0.876	0	0
mRNA 3'-end processing	R-HSA-72187	1.346295e-01	0.871	0	0
Developmental Biology	R-HSA-1266738	1.351493e-01	0.869	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.366915e-01	0.864	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.366915e-01	0.864	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.534263e-01	0.814	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.534263e-01	0.814	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.534263e-01	0.814	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.534263e-01	0.814	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	1.441348e-01	0.841	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.441348e-01	0.841	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.441348e-01	0.841	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	1.441348e-01	0.841	0	0
C6 deamination of adenosine	R-HSA-75102	1.441348e-01	0.841	0	0
Potassium transport channels	R-HSA-1296067	1.441348e-01	0.841	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.503792e-01	0.823	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.503792e-01	0.823	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	1.503792e-01	0.823	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.503792e-01	0.823	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.503792e-01	0.823	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	1.425628e-01	0.846	0	0
WNT mediated activation of DVL	R-HSA-201688	1.425628e-01	0.846	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.425628e-01	0.846	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.419411e-01	0.848	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.419411e-01	0.848	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.419411e-01	0.848	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.521082e-01	0.818	0	0
Trafficking of AMPA receptors	R-HSA-399719	1.697530e-01	0.770	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.671130e-01	0.777	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.633447e-01	0.787	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.836524e-01	0.736	0	0
G1/S Transition	R-HSA-69206	1.412584e-01	0.850	0	0
Signaling by ERBB2	R-HSA-1227986	1.702287e-01	0.769	0	0
RMTs methylate histone arginines	R-HSA-3214858	1.650318e-01	0.782	0	0
Signal attenuation	R-HSA-74749	1.737805e-01	0.760	0	0
ERK/MAPK targets	R-HSA-198753	1.476872e-01	0.831	0	0
Frs2-mediated activation	R-HSA-170968	1.571490e-01	0.804	0	0
Regulation of CDH11 function	R-HSA-9762292	1.737805e-01	0.760	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	1.646952e-01	0.783	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.529340e-01	0.815	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.529340e-01	0.815	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.529340e-01	0.815	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.425628e-01	0.846	0	0
Generation of second messenger molecules	R-HSA-202433	1.671130e-01	0.777	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.703142e-01	0.769	0	0
MAP kinase activation	R-HSA-450294	1.836524e-01	0.736	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.787586e-01	0.748	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.425628e-01	0.846	0	0
MAPK family signaling cascades	R-HSA-5683057	1.693822e-01	0.771	0	0
Protein ubiquitination	R-HSA-8852135	1.599218e-01	0.796	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.755246e-01	0.756	0	0
Amyloid fiber formation	R-HSA-977225	1.676674e-01	0.776	0	0
Glycolysis	R-HSA-70171	1.728869e-01	0.762	0	0
Interleukin-1 processing	R-HSA-448706	1.425628e-01	0.846	0	0
Gene Silencing by RNA	R-HSA-211000	1.460772e-01	0.835	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.842984e-01	0.734	0	0
Signaling by EGFR	R-HSA-177929	1.877861e-01	0.726	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.877861e-01	0.726	0	0
Potassium Channels	R-HSA-1296071	1.881235e-01	0.726	0	0
DNA strand elongation	R-HSA-69190	1.882995e-01	0.725	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.882995e-01	0.725	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.888778e-01	0.724	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.888778e-01	0.724	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.888778e-01	0.724	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.888778e-01	0.724	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.888778e-01	0.724	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	1.891539e-01	0.723	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.898608e-01	0.722	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.902905e-01	0.721	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.908608e-01	0.719	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.908608e-01	0.719	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.833203e-01	0.548	0	0
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.833203e-01	0.548	0	0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	2.833203e-01	0.548	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.833203e-01	0.548	0	0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	2.833203e-01	0.548	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.833203e-01	0.548	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.833203e-01	0.548	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.833203e-01	0.548	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.833203e-01	0.548	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.833203e-01	0.548	0	0
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	2.833203e-01	0.548	0	0
MET interacts with TNS proteins	R-HSA-8875513	2.030211e-01	0.692	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	2.030211e-01	0.692	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	2.030211e-01	0.692	0	0
MET activates PTPN11	R-HSA-8865999	2.030211e-01	0.692	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	2.639898e-01	0.578	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.639898e-01	0.578	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.639898e-01	0.578	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.639898e-01	0.578	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.639898e-01	0.578	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.639898e-01	0.578	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	2.639898e-01	0.578	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	2.639898e-01	0.578	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	3.932904e-01	0.405	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.932904e-01	0.405	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	3.932904e-01	0.405	0	0
XAV939 stabilizes AXIN	R-HSA-5545619	3.932904e-01	0.405	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.932904e-01	0.405	0	0
Intestinal infectious diseases	R-HSA-8942233	3.932904e-01	0.405	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.932904e-01	0.405	0	0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.932904e-01	0.405	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.932904e-01	0.405	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.932904e-01	0.405	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.932904e-01	0.405	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.932904e-01	0.405	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.932904e-01	0.405	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.932904e-01	0.405	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.932904e-01	0.405	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.932904e-01	0.405	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.932904e-01	0.405	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.932904e-01	0.405	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	3.932904e-01	0.405	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.932904e-01	0.405	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	3.932904e-01	0.405	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.932904e-01	0.405	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.932904e-01	0.405	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.932904e-01	0.405	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	2.336786e-01	0.631	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.336786e-01	0.631	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	2.336786e-01	0.631	0	0
Ca2+ activated K+ channels	R-HSA-1296052	2.336786e-01	0.631	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.336786e-01	0.631	0	0
SOS-mediated signalling	R-HSA-112412	2.336786e-01	0.631	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.070768e-01	0.684	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.070768e-01	0.684	0	0
Signaling by APC mutants	R-HSA-4839744	2.070768e-01	0.684	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.070768e-01	0.684	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.070768e-01	0.684	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.070768e-01	0.684	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.250166e-01	0.488	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.250166e-01	0.488	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	3.250166e-01	0.488	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	3.250166e-01	0.488	0	0
Defective F9 activation	R-HSA-9673221	3.250166e-01	0.488	0	0
RSK activation	R-HSA-444257	2.779687e-01	0.556	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.420089e-01	0.616	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.143258e-01	0.669	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	2.430118e-01	0.614	0	0
Differentiation of T cells	R-HSA-9945266	2.430118e-01	0.614	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	2.781365e-01	0.556	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.229536e-01	0.491	0	0
Lipophagy	R-HSA-9613354	3.229536e-01	0.491	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.229536e-01	0.491	0	0
Phosphorylation of Emi1	R-HSA-176417	3.846489e-01	0.415	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.846489e-01	0.415	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.846489e-01	0.415	0	0
Signaling by MAPK mutants	R-HSA-9652817	3.846489e-01	0.415	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.863915e-01	0.313	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	4.863915e-01	0.313	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.863915e-01	0.313	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.863915e-01	0.313	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	4.863915e-01	0.313	0	0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.863915e-01	0.313	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.863915e-01	0.313	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.863915e-01	0.313	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.863915e-01	0.313	0	0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.863915e-01	0.313	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.408637e-01	0.618	0	0
Co-inhibition by CTLA4	R-HSA-389513	2.408637e-01	0.618	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.408637e-01	0.618	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.408637e-01	0.618	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.408637e-01	0.618	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.408637e-01	0.618	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.740418e-01	0.562	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.740418e-01	0.562	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.150356e-01	0.502	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.150356e-01	0.502	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	3.150356e-01	0.502	0	0
Formation of axial mesoderm	R-HSA-9796292	3.150356e-01	0.502	0	0
Integrin signaling	R-HSA-354192	2.076830e-01	0.683	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.076830e-01	0.683	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.076830e-01	0.683	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.683081e-01	0.571	0	0
Formation of apoptosome	R-HSA-111458	3.679552e-01	0.434	0	0
Regulation of the apoptosome activity	R-HSA-9627069	3.679552e-01	0.434	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.679552e-01	0.434	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	3.679552e-01	0.434	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	3.679552e-01	0.434	0	0
Folding of actin by CCT/TriC	R-HSA-390450	3.679552e-01	0.434	0	0
Signaling by Erythropoietin	R-HSA-9006335	2.327084e-01	0.633	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.327084e-01	0.633	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.327084e-01	0.633	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.058278e-01	0.515	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.058278e-01	0.515	0	0
MAP2K and MAPK activation	R-HSA-5674135	2.001301e-01	0.699	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.964724e-01	0.528	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	4.418783e-01	0.355	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	4.418783e-01	0.355	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	4.418783e-01	0.355	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.421289e-01	0.616	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.421289e-01	0.616	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	4.123981e-01	0.385	0	0
Formation of the posterior neural plate	R-HSA-9832991	4.123981e-01	0.385	0	0
HIV Transcription Elongation	R-HSA-167169	2.620671e-01	0.582	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.620671e-01	0.582	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.620671e-01	0.582	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.132926e-01	0.504	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.132926e-01	0.504	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.132926e-01	0.504	0	0
Spry regulation of FGF signaling	R-HSA-1295596	3.895916e-01	0.409	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.895916e-01	0.409	0	0
G1/S-Specific Transcription	R-HSA-69205	2.920811e-01	0.534	0	0
Metabolism of non-coding RNA	R-HSA-194441	2.332774e-01	0.632	0	0
snRNP Assembly	R-HSA-191859	2.332774e-01	0.632	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.706288e-01	0.431	0	0
Interleukin receptor SHC signaling	R-HSA-912526	3.542178e-01	0.451	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.396532e-01	0.469	0	0
HIV elongation arrest and recovery	R-HSA-167287	3.396532e-01	0.469	0	0
Formation of the Early Elongation Complex	R-HSA-113418	3.396532e-01	0.469	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	3.396532e-01	0.469	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	3.396532e-01	0.469	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.033917e-01	0.518	0	0
Cellular response to heat stress	R-HSA-3371556	1.946573e-01	0.711	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.246349e-01	0.489	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.510177e-01	0.455	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	3.834394e-01	0.416	0	0
Deadenylation of mRNA	R-HSA-429947	3.834394e-01	0.416	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.265578e-01	0.370	0	0
Phosphorylation of the APC/C	R-HSA-176412	4.265578e-01	0.370	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.558083e-01	0.341	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.558083e-01	0.341	0	0
ERKs are inactivated	R-HSA-202670	4.558083e-01	0.341	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.960384e-01	0.304	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	4.960384e-01	0.304	0	0
Netrin mediated repulsion signals	R-HSA-418886	4.960384e-01	0.304	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.960384e-01	0.304	0	0
PTK6 Expression	R-HSA-8849473	4.960384e-01	0.304	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.960384e-01	0.304	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.960384e-01	0.304	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.960384e-01	0.304	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.652106e-01	0.248	0	0
Defective ABCA1 causes TGD	R-HSA-5682113	5.652106e-01	0.248	0	0
Invadopodia formation	R-HSA-8941237	5.652106e-01	0.248	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	5.652106e-01	0.248	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.652106e-01	0.248	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.652106e-01	0.248	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.757423e-01	0.425	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.757423e-01	0.425	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.068030e-01	0.513	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.930381e-01	0.406	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.930381e-01	0.406	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.930381e-01	0.406	0	0
Tight junction interactions	R-HSA-420029	4.126671e-01	0.384	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.126671e-01	0.384	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.354776e-01	0.361	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.354776e-01	0.361	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.354776e-01	0.361	0	0
Attenuation phase	R-HSA-3371568	3.834211e-01	0.416	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.005727e-01	0.397	0	0
Phase 2 - plateau phase	R-HSA-5576893	4.629214e-01	0.334	0	0
EGFR downregulation	R-HSA-182971	4.198022e-01	0.377	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.198022e-01	0.377	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.198022e-01	0.377	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.978066e-01	0.303	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.978066e-01	0.303	0	0
Polymerase switching	R-HSA-69091	4.978066e-01	0.303	0	0
Leading Strand Synthesis	R-HSA-69109	4.978066e-01	0.303	0	0
Scavenging by Class F Receptors	R-HSA-3000484	4.978066e-01	0.303	0	0
Transcription of the HIV genome	R-HSA-167172	3.893258e-01	0.410	0	0
Orc1 removal from chromatin	R-HSA-68949	4.161039e-01	0.381	0	0
Voltage gated Potassium channels	R-HSA-1296072	4.501513e-01	0.347	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.984370e-01	0.302	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.984370e-01	0.302	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	5.467236e-01	0.262	0	0
Regulation by c-FLIP	R-HSA-3371378	5.467236e-01	0.262	0	0
Dimerization of procaspase-8	R-HSA-69416	5.467236e-01	0.262	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	5.467236e-01	0.262	0	0
MET receptor recycling	R-HSA-8875656	5.467236e-01	0.262	0	0
FGFR1b ligand binding and activation	R-HSA-190370	5.467236e-01	0.262	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	5.467236e-01	0.262	0	0
Activation of RAS in B cells	R-HSA-1169092	5.467236e-01	0.262	0	0
Formation of annular gap junctions	R-HSA-196025	5.467236e-01	0.262	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	5.467236e-01	0.262	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.369724e-01	0.360	0	0
PTEN Regulation	R-HSA-6807070	3.712893e-01	0.430	0	0
Regulation of necroptotic cell death	R-HSA-5675482	4.728716e-01	0.325	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	4.728716e-01	0.325	0	0
FGFR2 alternative splicing	R-HSA-6803529	4.987267e-01	0.302	0	0
Notch-HLH transcription pathway	R-HSA-350054	4.987267e-01	0.302	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.187735e-01	0.378	0	0
MET promotes cell motility	R-HSA-8875878	4.747123e-01	0.324	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.120983e-01	0.385	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.120983e-01	0.385	0	0
Translation initiation complex formation	R-HSA-72649	4.577876e-01	0.339	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.988774e-01	0.302	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.988774e-01	0.302	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.381007e-01	0.269	0	0
GAB1 signalosome	R-HSA-180292	5.328992e-01	0.273	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.328992e-01	0.273	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.328992e-01	0.273	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	4.990410e-01	0.302	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.990410e-01	0.302	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.266842e-01	0.278	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.266842e-01	0.278	0	0
Late endosomal microautophagy	R-HSA-9615710	5.266842e-01	0.278	0	0
Dual Incision in GG-NER	R-HSA-5696400	5.246214e-01	0.280	0	0
COPI-mediated anterograde transport	R-HSA-6807878	5.147925e-01	0.288	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.538410e-01	0.257	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.590704e-01	0.253	0	0
Regulation of signaling by CBL	R-HSA-912631	5.661413e-01	0.247	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.743302e-01	0.241	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	2.677586e-01	0.572	0	0
Regulation of mitotic cell cycle	R-HSA-453276	4.443269e-01	0.352	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.443269e-01	0.352	0	0
RNA Polymerase III Transcription	R-HSA-74158	5.743302e-01	0.241	0	0
Nucleotide Excision Repair	R-HSA-5696398	3.952418e-01	0.403	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.655423e-01	0.248	0	0
Hedgehog 'off' state	R-HSA-5610787	3.926273e-01	0.406	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.735158e-01	0.563	0	0
Formation of definitive endoderm	R-HSA-9823730	4.031579e-01	0.395	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.366398e-01	0.270	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.040419e-01	0.690	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	4.265578e-01	0.370	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	4.031579e-01	0.395	0	0
Switching of origins to a post-replicative state	R-HSA-69052	3.756253e-01	0.425	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.669895e-01	0.435	0	0
Telomere Extension By Telomerase	R-HSA-171319	4.988774e-01	0.302	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.209640e-01	0.376	0	0
mRNA Editing	R-HSA-75072	3.229536e-01	0.491	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	4.629214e-01	0.334	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.329631e-01	0.478	0	0
Signaling by PTK6	R-HSA-8848021	2.998879e-01	0.523	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.998879e-01	0.523	0	0
MHC class II antigen presentation	R-HSA-2132295	5.128629e-01	0.290	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	4.040132e-01	0.394	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	2.930824e-01	0.533	0	0
Aggrephagy	R-HSA-9646399	5.229535e-01	0.282	0	0
TNF signaling	R-HSA-75893	3.800624e-01	0.420	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.250166e-01	0.488	0	0
Myogenesis	R-HSA-525793	2.873343e-01	0.542	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.701144e-01	0.568	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.987267e-01	0.302	0	0
Ca2+ pathway	R-HSA-4086398	4.808832e-01	0.318	0	0
p75NTR signals via NF-kB	R-HSA-193639	3.895916e-01	0.409	0	0
Resolution of D-Loop Structures	R-HSA-5693537	3.510177e-01	0.455	0	0
TCR signaling	R-HSA-202403	3.832990e-01	0.416	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.229536e-01	0.491	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.679552e-01	0.434	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.265035e-01	0.486	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.834394e-01	0.416	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.777588e-01	0.556	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.711058e-01	0.431	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.381007e-01	0.269	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.394575e-01	0.268	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.629214e-01	0.334	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.639898e-01	0.578	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.679552e-01	0.434	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.372322e-01	0.472	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	4.960384e-01	0.304	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.960384e-01	0.304	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	3.757423e-01	0.425	0	0
Nuclear RNA decay	R-HSA-9930044	4.728716e-01	0.325	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.246349e-01	0.489	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.746086e-01	0.426	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.906909e-01	0.537	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.553014e-01	0.593	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.486698e-01	0.604	0	0
Apoptotic factor-mediated response	R-HSA-111471	3.381071e-01	0.471	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	2.336786e-01	0.631	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.143258e-01	0.669	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.774439e-01	0.321	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.746086e-01	0.426	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.158412e-01	0.381	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.777588e-01	0.556	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	3.250166e-01	0.488	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.229536e-01	0.491	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	3.229536e-01	0.491	0	0
cGMP effects	R-HSA-418457	3.523087e-01	0.453	0	0
Signaling by WNT in cancer	R-HSA-4791275	3.023069e-01	0.520	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	3.542178e-01	0.451	0	0
NF-kB is activated and signals survival	R-HSA-209560	4.558083e-01	0.341	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.978066e-01	0.303	0	0
Adrenoceptors	R-HSA-390696	5.467236e-01	0.262	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	5.467236e-01	0.262	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.158412e-01	0.381	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	5.661413e-01	0.247	0	0
HIV Life Cycle	R-HSA-162587	5.359702e-01	0.271	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.417438e-01	0.355	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.993434e-01	0.700	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	2.278321e-01	0.642	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.964724e-01	0.528	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.033917e-01	0.518	0	0
Repression of WNT target genes	R-HSA-4641265	4.978066e-01	0.303	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.386509e-01	0.622	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.442609e-01	0.463	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	4.987841e-01	0.302	0	0
Autophagy	R-HSA-9612973	3.105655e-01	0.508	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.984370e-01	0.302	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	4.397512e-01	0.357	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.336563e-01	0.631	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.414475e-01	0.266	0	0
Integration of energy metabolism	R-HSA-163685	3.340584e-01	0.476	0	0
Signaling by SCF-KIT	R-HSA-1433557	2.357337e-01	0.628	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.705245e-01	0.327	0	0
Prolonged ERK activation events	R-HSA-169893	2.430118e-01	0.614	0	0
Activation of BH3-only proteins	R-HSA-114452	3.930381e-01	0.406	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	2.336563e-01	0.631	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.989117e-01	0.701	0	0
Selective autophagy	R-HSA-9663891	5.489602e-01	0.260	0	0
Co-inhibition by PD-1	R-HSA-389948	4.218829e-01	0.375	0	0
Formation of the anterior neural plate	R-HSA-9823739	2.130072e-01	0.672	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.846489e-01	0.415	0	0
HDL assembly	R-HSA-8963896	3.523087e-01	0.453	0	0
Abacavir transmembrane transport	R-HSA-2161517	4.418783e-01	0.355	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.558083e-01	0.341	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.757423e-01	0.425	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	3.898125e-01	0.409	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.984370e-01	0.302	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	5.467236e-01	0.262	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	5.467236e-01	0.262	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	5.467236e-01	0.262	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.728716e-01	0.325	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	4.989601e-01	0.302	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.215677e-01	0.283	0	0
Eukaryotic Translation Elongation	R-HSA-156842	5.314459e-01	0.275	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.987654e-01	0.302	0	0
Cilium Assembly	R-HSA-5617833	4.423124e-01	0.354	0	0
Interleukin-17 signaling	R-HSA-448424	3.237118e-01	0.490	0	0
Macroautophagy	R-HSA-1632852	3.965495e-01	0.402	0	0
Signaling by TGFB family members	R-HSA-9006936	3.561421e-01	0.448	0	0
Mismatch Repair	R-HSA-5358508	5.328992e-01	0.273	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.327084e-01	0.633	0	0
Transmission across Chemical Synapses	R-HSA-112315	4.716554e-01	0.326	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.076830e-01	0.683	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.629214e-01	0.334	0	0
Interleukin-1 family signaling	R-HSA-446652	4.736790e-01	0.325	0	0
Platelet calcium homeostasis	R-HSA-418360	3.662793e-01	0.436	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.978066e-01	0.303	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.743894e-01	0.562	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	2.639898e-01	0.578	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.895916e-01	0.409	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	5.467236e-01	0.262	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	4.728716e-01	0.325	0	0
Processing of SMDT1	R-HSA-8949664	5.381007e-01	0.269	0	0
Metabolism of RNA	R-HSA-8953854	4.972574e-01	0.303	0	0
Signalling to ERKs	R-HSA-187687	4.005727e-01	0.397	0	0
Cardiogenesis	R-HSA-9733709	2.076830e-01	0.683	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	3.033917e-01	0.518	0	0
Cellular responses to stress	R-HSA-2262752	2.272290e-01	0.644	0	0
Negative regulation of FLT3	R-HSA-9706369	2.430118e-01	0.614	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.619172e-01	0.582	0	0
RAF/MAP kinase cascade	R-HSA-5673001	3.279544e-01	0.484	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.893735e-01	0.410	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.420089e-01	0.616	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	3.679552e-01	0.434	0	0
Neurofascin interactions	R-HSA-447043	4.418783e-01	0.355	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.464835e-01	0.262	0	0
Signaling by TGFBR3	R-HSA-9839373	1.960688e-01	0.708	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.497700e-01	0.260	0	0
Interleukin-2 family signaling	R-HSA-451927	3.834211e-01	0.416	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	3.510177e-01	0.455	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.697890e-01	0.569	0	0
Inhibition of PKR	R-HSA-169131	2.833203e-01	0.548	0	0
Signaling by AMER1 mutants	R-HSA-4839748	2.420089e-01	0.616	0	0
Signaling by AXIN mutants	R-HSA-4839735	2.420089e-01	0.616	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.430118e-01	0.614	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	3.846489e-01	0.415	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.863915e-01	0.313	0	0
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	4.863915e-01	0.313	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	2.964724e-01	0.528	0	0
Bicarbonate transporters	R-HSA-425381	4.123981e-01	0.385	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	4.123981e-01	0.385	0	0
Smooth Muscle Contraction	R-HSA-445355	2.234770e-01	0.651	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	4.265578e-01	0.370	0	0
MET activates STAT3	R-HSA-8875791	5.652106e-01	0.248	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.898479e-01	0.538	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.354776e-01	0.361	0	0
Disorders of Developmental Biology	R-HSA-9675151	4.629214e-01	0.334	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	4.417438e-01	0.355	0	0
Signaling by LTK	R-HSA-9842663	4.978066e-01	0.303	0	0
Regulation of insulin secretion	R-HSA-422356	3.625601e-01	0.441	0	0
FLT3 signaling in disease	R-HSA-9682385	5.743302e-01	0.241	0	0
Oncogene Induced Senescence	R-HSA-2559585	4.005727e-01	0.397	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	5.394575e-01	0.268	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.781365e-01	0.556	0	0
The NLRP3 inflammasome	R-HSA-844456	3.706288e-01	0.431	0	0
GPVI-mediated activation cascade	R-HSA-114604	5.743302e-01	0.241	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.462414e-01	0.350	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	3.229536e-01	0.491	0	0
Formation of the nephric duct	R-HSA-9830364	4.126671e-01	0.384	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.176328e-01	0.662	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.265035e-01	0.486	0	0
RUNX2 regulates bone development	R-HSA-8941326	5.743302e-01	0.241	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	3.250166e-01	0.488	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.846489e-01	0.415	0	0
Nef and signal transduction	R-HSA-164944	4.418783e-01	0.355	0	0
CHL1 interactions	R-HSA-447041	4.960384e-01	0.304	0	0
Pervasive developmental disorders	R-HSA-9005895	4.978066e-01	0.303	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.978066e-01	0.303	0	0
Disorders of Nervous System Development	R-HSA-9697154	4.978066e-01	0.303	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	4.984370e-01	0.302	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.381007e-01	0.269	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.989601e-01	0.302	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.464835e-01	0.262	0	0
Signaling by NOTCH	R-HSA-157118	4.781469e-01	0.320	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.336786e-01	0.631	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.022333e-01	0.520	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.381007e-01	0.269	0	0
ISG15 antiviral mechanism	R-HSA-1169408	5.170029e-01	0.287	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	3.437019e-01	0.464	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	2.356585e-01	0.628	1	1
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.661413e-01	0.247	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.932904e-01	0.405	0	0
DSCAM interactions	R-HSA-376172	4.863915e-01	0.313	0	0
Maturation of nucleoprotein	R-HSA-9683610	3.150356e-01	0.502	0	0
Tandem pore domain potassium channels	R-HSA-1296346	3.679552e-01	0.434	0	0
Synthesis of PI	R-HSA-1483226	4.123981e-01	0.385	0	0
Syndecan interactions	R-HSA-3000170	3.542178e-01	0.451	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.652106e-01	0.248	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	5.652106e-01	0.248	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.990058e-01	0.302	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.437572e-01	0.265	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.590704e-01	0.253	0	0
Glucose metabolism	R-HSA-70326	3.475342e-01	0.459	0	0
Diseases of DNA repair	R-HSA-9675135	5.437572e-01	0.265	0	0
STING mediated induction of host immune responses	R-HSA-1834941	2.143258e-01	0.669	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.295122e-01	0.639	0	0
Stimuli-sensing channels	R-HSA-2672351	5.288568e-01	0.277	1	1
Zygotic genome activation (ZGA)	R-HSA-9819196	2.683081e-01	0.571	0	0
PECAM1 interactions	R-HSA-210990	4.123981e-01	0.385	0	0
Maturation of nucleoprotein	R-HSA-9694631	3.706288e-01	0.431	0	0
Histamine receptors	R-HSA-390650	5.652106e-01	0.248	0	0
Nuclear import of Rev protein	R-HSA-180746	5.246214e-01	0.280	0	0
Sodium/Proton exchangers	R-HSA-425986	2.779687e-01	0.556	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.863915e-01	0.313	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	4.960384e-01	0.304	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	5.652106e-01	0.248	0	0
Interleukin-18 signaling	R-HSA-9012546	5.467236e-01	0.262	0	0
Other interleukin signaling	R-HSA-449836	5.661413e-01	0.247	0	0
Interleukin-7 signaling	R-HSA-1266695	2.619172e-01	0.582	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.130072e-01	0.672	0	0
Leukotriene receptors	R-HSA-391906	4.418783e-01	0.355	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	4.960384e-01	0.304	0	0
FasL/ CD95L signaling	R-HSA-75157	5.652106e-01	0.248	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	5.328992e-01	0.273	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	5.157972e-01	0.288	0	0
SARS-CoV-1 Infection	R-HSA-9678108	5.458417e-01	0.263	0	0
Interleukin-12 family signaling	R-HSA-447115	2.562450e-01	0.591	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.764758e-01	0.239	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.764758e-01	0.239	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	5.764758e-01	0.239	0	0
HCMV Early Events	R-HSA-9609690	5.769054e-01	0.239	0	0
Budding and maturation of HIV virion	R-HSA-162588	5.802574e-01	0.236	0	0
Downstream signal transduction	R-HSA-186763	5.802574e-01	0.236	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	5.824777e-01	0.235	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	5.839761e-01	0.234	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.878405e-01	0.231	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	5.917563e-01	0.228	0	0
Gap junction degradation	R-HSA-190873	5.937251e-01	0.226	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.937251e-01	0.226	0	0
CASP8 activity is inhibited	R-HSA-5218900	5.937251e-01	0.226	0	0
ARMS-mediated activation	R-HSA-170984	5.937251e-01	0.226	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	5.937251e-01	0.226	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	5.937251e-01	0.226	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	5.943555e-01	0.226	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	5.977451e-01	0.223	0	0
Aquaporin-mediated transport	R-HSA-445717	5.977451e-01	0.223	0	0
Negative regulation of MET activity	R-HSA-6807004	5.980321e-01	0.223	0	0
Protein hydroxylation	R-HSA-9629569	5.980321e-01	0.223	0	0
Signal transduction by L1	R-HSA-445144	5.980321e-01	0.223	0	0
Ovarian tumor domain proteases	R-HSA-5689896	5.982360e-01	0.223	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.982360e-01	0.223	0	0
Synthesis of DNA	R-HSA-69239	6.038150e-01	0.219	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.065610e-01	0.217	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.077034e-01	0.216	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.077034e-01	0.216	0	0
IRE1alpha activates chaperones	R-HSA-381070	6.127653e-01	0.213	0	0
Erythropoietin activates RAS	R-HSA-9027284	6.127842e-01	0.213	0	0
Processive synthesis on the lagging strand	R-HSA-69183	6.127842e-01	0.213	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.127842e-01	0.213	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.127842e-01	0.213	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.127842e-01	0.213	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.127842e-01	0.213	0	0
Protein methylation	R-HSA-8876725	6.127842e-01	0.213	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.127842e-01	0.213	0	0
Signaling by FGFR4	R-HSA-5654743	6.139582e-01	0.212	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	6.155519e-01	0.211	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.155519e-01	0.211	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.155519e-01	0.211	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.155519e-01	0.211	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.155519e-01	0.211	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	6.164025e-01	0.210	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.180526e-01	0.209	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.180526e-01	0.209	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.214308e-01	0.207	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.214308e-01	0.207	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.236678e-01	0.205	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.244696e-01	0.204	0	0
PI3K Cascade	R-HSA-109704	6.279950e-01	0.202	0	0
Lagging Strand Synthesis	R-HSA-69186	6.284735e-01	0.202	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.305774e-01	0.200	0	0
ATP sensitive Potassium channels	R-HSA-1296025	6.319377e-01	0.199	0	0
Signaling by MAP2K mutants	R-HSA-9652169	6.319377e-01	0.199	0	0
Defective MAT1A causes MATD	R-HSA-5579024	6.319377e-01	0.199	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	6.319377e-01	0.199	0	0
Regulation of gap junction activity	R-HSA-191650	6.319377e-01	0.199	0	0
Vasopressin-like receptors	R-HSA-388479	6.319377e-01	0.199	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	6.319377e-01	0.199	0	0
NADE modulates death signalling	R-HSA-205025	6.319377e-01	0.199	0	0
Sensory perception of sour taste	R-HSA-9729555	6.319377e-01	0.199	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	6.319377e-01	0.199	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	6.319377e-01	0.199	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	6.319377e-01	0.199	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.369797e-01	0.196	0	0
PI3K/AKT activation	R-HSA-198203	6.369797e-01	0.196	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.369797e-01	0.196	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	6.369797e-01	0.196	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.369797e-01	0.196	0	0
Signaling by Leptin	R-HSA-2586552	6.369797e-01	0.196	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	6.399866e-01	0.194	0	0
IRS-mediated signalling	R-HSA-112399	6.407172e-01	0.193	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.421357e-01	0.192	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	6.421357e-01	0.192	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.421357e-01	0.192	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.438675e-01	0.191	0	0
Signaling by ALK	R-HSA-201556	6.438675e-01	0.191	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.464247e-01	0.189	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.469364e-01	0.189	0	0
Killing mechanisms	R-HSA-9664420	6.469364e-01	0.189	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.469364e-01	0.189	0	0
Peptide chain elongation	R-HSA-156902	6.473992e-01	0.189	0	0
Insulin receptor signalling cascade	R-HSA-74751	6.523793e-01	0.185	0	0
IGF1R signaling cascade	R-HSA-2428924	6.523793e-01	0.185	0	0
Adaptive Immune System	R-HSA-1280218	6.536376e-01	0.185	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.543674e-01	0.184	0	0
Signaling by FGFR3	R-HSA-5654741	6.558591e-01	0.183	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.573973e-01	0.182	0	0
Dual incision in TC-NER	R-HSA-6782135	6.591181e-01	0.181	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.655078e-01	0.177	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	6.655078e-01	0.177	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	6.655078e-01	0.177	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	6.655078e-01	0.177	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.668302e-01	0.176	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	6.668302e-01	0.176	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.675411e-01	0.176	0	0
Inflammasomes	R-HSA-622312	6.675411e-01	0.176	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.696507e-01	0.174	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.723705e-01	0.172	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.757753e-01	0.170	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	6.765305e-01	0.170	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	6.765305e-01	0.170	0	0
Interleukin-2 signaling	R-HSA-9020558	6.765305e-01	0.170	0	0
LGI-ADAM interactions	R-HSA-5682910	6.765305e-01	0.170	0	0
Suppression of apoptosis	R-HSA-9635465	6.765305e-01	0.170	0	0
Extension of Telomeres	R-HSA-180786	6.769709e-01	0.169	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.771887e-01	0.169	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.771887e-01	0.169	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.771887e-01	0.169	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.788913e-01	0.168	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.788913e-01	0.168	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.788913e-01	0.168	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.788913e-01	0.168	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.788913e-01	0.168	0	0
Response to metal ions	R-HSA-5660526	6.788913e-01	0.168	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.794527e-01	0.168	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.847615e-01	0.164	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.847615e-01	0.164	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.863220e-01	0.163	0	0
Activation of AMPA receptors	R-HSA-399710	6.884275e-01	0.162	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.884275e-01	0.162	0	0
PTK6 Down-Regulation	R-HSA-8849472	6.884275e-01	0.162	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	6.884275e-01	0.162	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.884275e-01	0.162	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	6.884275e-01	0.162	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.884275e-01	0.162	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.884275e-01	0.162	0	0
Activation of AKT2	R-HSA-165158	6.884275e-01	0.162	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	6.884275e-01	0.162	0	0
PTK6 Activates STAT3	R-HSA-8849474	6.884275e-01	0.162	0	0
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.884275e-01	0.162	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.884275e-01	0.162	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	6.884275e-01	0.162	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.884275e-01	0.162	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.886309e-01	0.162	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	6.899161e-01	0.161	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.914770e-01	0.160	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	6.917338e-01	0.160	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	6.917338e-01	0.160	0	0
Regulation of gene expression in beta cells	R-HSA-210745	6.917338e-01	0.160	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.942566e-01	0.158	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.942566e-01	0.158	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.942566e-01	0.158	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.942566e-01	0.158	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.942566e-01	0.158	0	0
Signaling by FGFR2	R-HSA-5654738	7.036154e-01	0.153	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.036154e-01	0.153	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	7.052180e-01	0.152	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.062880e-01	0.151	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.062880e-01	0.151	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.062880e-01	0.151	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.062880e-01	0.151	0	0
HIV Transcription Initiation	R-HSA-167161	7.062880e-01	0.151	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.062880e-01	0.151	0	0
Intra-Golgi traffic	R-HSA-6811438	7.062880e-01	0.151	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	7.086476e-01	0.150	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.086476e-01	0.150	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.086476e-01	0.150	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.086476e-01	0.150	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.086476e-01	0.150	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	7.089369e-01	0.149	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	7.105473e-01	0.148	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.105473e-01	0.148	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.105473e-01	0.148	0	0
Signaling by FGFR in disease	R-HSA-1226099	7.106130e-01	0.148	0	0
Signaling by ERBB4	R-HSA-1236394	7.106130e-01	0.148	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.115071e-01	0.148	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.124953e-01	0.147	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.124953e-01	0.147	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.124953e-01	0.147	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.124953e-01	0.147	0	0
Sodium/Calcium exchangers	R-HSA-425561	7.124953e-01	0.147	0	0
Integration of provirus	R-HSA-162592	7.124953e-01	0.147	0	0
GPER1 signaling	R-HSA-9634597	7.134218e-01	0.147	0	0
DAP12 signaling	R-HSA-2424491	7.146939e-01	0.146	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.146939e-01	0.146	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.146939e-01	0.146	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.146939e-01	0.146	0	0
Regulated Necrosis	R-HSA-5218859	7.183804e-01	0.144	0	0
Triglyceride catabolism	R-HSA-163560	7.198256e-01	0.143	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.205354e-01	0.142	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.254625e-01	0.139	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.294094e-01	0.137	0	0
DNA Damage Bypass	R-HSA-73893	7.311225e-01	0.136	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.347560e-01	0.134	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.347560e-01	0.134	0	0
Plasma lipoprotein assembly	R-HSA-8963898	7.347560e-01	0.134	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	7.362365e-01	0.133	0	0
Plus-strand DNA synthesis	R-HSA-164525	7.362500e-01	0.133	0	0
PDE3B signalling	R-HSA-165160	7.362500e-01	0.133	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	7.362500e-01	0.133	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	7.362500e-01	0.133	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	7.362500e-01	0.133	0	0
PKB-mediated events	R-HSA-109703	7.362500e-01	0.133	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	7.362500e-01	0.133	0	0
Signaling by RNF43 mutants	R-HSA-5340588	7.362500e-01	0.133	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	7.362500e-01	0.133	0	0
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	7.362500e-01	0.133	0	0
Terminal pathway of complement	R-HSA-166665	7.362500e-01	0.133	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	7.362500e-01	0.133	0	0
NGF-independant TRKA activation	R-HSA-187024	7.362500e-01	0.133	0	0
Pentose phosphate pathway disease	R-HSA-6791465	7.362500e-01	0.133	0	0
Formation of the Editosome	R-HSA-75094	7.362500e-01	0.133	0	0
Synthesis of PS	R-HSA-1483101	7.362500e-01	0.133	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	7.362500e-01	0.133	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	7.362500e-01	0.133	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	7.362500e-01	0.133	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	7.362500e-01	0.133	0	0
TRAIL signaling	R-HSA-75158	7.362500e-01	0.133	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	7.362500e-01	0.133	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.364150e-01	0.133	0	0
Cargo concentration in the ER	R-HSA-5694530	7.364150e-01	0.133	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	7.364150e-01	0.133	0	0
Signaling by FGFR1	R-HSA-5654736	7.368767e-01	0.133	0	0
Signaling by Hedgehog	R-HSA-5358351	7.380001e-01	0.132	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.425768e-01	0.129	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.425768e-01	0.129	0	0
Vesicle-mediated transport	R-HSA-5653656	7.435495e-01	0.129	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.436251e-01	0.129	0	0
MET activates RAS signaling	R-HSA-8851805	7.450431e-01	0.128	0	0
IRAK1 recruits IKK complex	R-HSA-937039	7.450431e-01	0.128	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.450431e-01	0.128	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.450431e-01	0.128	0	0
p75NTR recruits signalling complexes	R-HSA-209543	7.450431e-01	0.128	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.450431e-01	0.128	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.450431e-01	0.128	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	7.450431e-01	0.128	0	0
Estrogen biosynthesis	R-HSA-193144	7.450431e-01	0.128	0	0
Interleukin-15 signaling	R-HSA-8983432	7.450431e-01	0.128	0	0
OAS antiviral response	R-HSA-8983711	7.450431e-01	0.128	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.450431e-01	0.128	0	0
Cap-dependent Translation Initiation	R-HSA-72737	7.456968e-01	0.127	0	0
Eukaryotic Translation Initiation	R-HSA-72613	7.456968e-01	0.127	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.481795e-01	0.126	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.488592e-01	0.126	0	0
Regulation of CDH1 Function	R-HSA-9764561	7.527231e-01	0.123	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.558884e-01	0.122	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.569021e-01	0.121	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	7.569021e-01	0.121	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.573210e-01	0.121	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.573210e-01	0.121	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.574053e-01	0.121	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.574778e-01	0.121	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	7.617146e-01	0.118	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.617146e-01	0.118	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.617146e-01	0.118	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.617146e-01	0.118	0	0
Hedgehog 'on' state	R-HSA-5632684	7.622532e-01	0.118	0	0
Interleukin-1 signaling	R-HSA-9020702	7.627648e-01	0.118	0	0
Eukaryotic Translation Termination	R-HSA-72764	7.692871e-01	0.114	0	0
Adenylate cyclase activating pathway	R-HSA-170660	7.743755e-01	0.111	0	0
FGFR1c ligand binding and activation	R-HSA-190373	7.743755e-01	0.111	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.743755e-01	0.111	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	7.743755e-01	0.111	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.743755e-01	0.111	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	7.743755e-01	0.111	0	0
STAT5 Activation	R-HSA-9645135	7.767347e-01	0.110	0	0
Erythropoietin activates STAT5	R-HSA-9027283	7.767347e-01	0.110	0	0
Uncoating of the HIV Virion	R-HSA-162585	7.767347e-01	0.110	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	7.767347e-01	0.110	0	0
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	7.767347e-01	0.110	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.767347e-01	0.110	0	0
MET Receptor Activation	R-HSA-6806942	7.767347e-01	0.110	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.767347e-01	0.110	0	0
G2/M DNA replication checkpoint	R-HSA-69478	7.767347e-01	0.110	0	0
Lactose synthesis	R-HSA-5653890	7.767347e-01	0.110	0	0
Hydrolysis of LPE	R-HSA-1483152	7.767347e-01	0.110	0	0
NADPH regeneration	R-HSA-389542	7.767347e-01	0.110	0	0
Lipid particle organization	R-HSA-8964572	7.767347e-01	0.110	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.774814e-01	0.109	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.774814e-01	0.109	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	7.780544e-01	0.109	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.785216e-01	0.109	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	7.785273e-01	0.109	0	0
Metalloprotease DUBs	R-HSA-5689901	7.785273e-01	0.109	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.785273e-01	0.109	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.851579e-01	0.105	0	0
Signaling by NODAL	R-HSA-1181150	7.851579e-01	0.105	0	0
Creatine metabolism	R-HSA-71288	7.851579e-01	0.105	0	0
Adipogenesis	R-HSA-9843745	7.874648e-01	0.104	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.874854e-01	0.104	0	0
Gastrulation	R-HSA-9758941	7.918037e-01	0.101	0	0
Signaling by MET	R-HSA-6806834	7.921630e-01	0.101	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.928969e-01	0.101	0	0
Diseases of Immune System	R-HSA-5260271	7.928969e-01	0.101	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	7.931174e-01	0.101	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.931174e-01	0.101	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.938682e-01	0.100	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	7.943379e-01	0.100	0	0
Circadian clock	R-HSA-9909396	7.968807e-01	0.099	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.981653e-01	0.098	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	7.981653e-01	0.098	0	0
Cristae formation	R-HSA-8949613	7.981653e-01	0.098	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	8.007125e-01	0.097	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.007125e-01	0.097	0	0
Removal of the Flap Intermediate	R-HSA-69166	8.007125e-01	0.097	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.007125e-01	0.097	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.007125e-01	0.097	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.007125e-01	0.097	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	8.066568e-01	0.093	0	0
Signalling to RAS	R-HSA-167044	8.066568e-01	0.093	0	0
Basigin interactions	R-HSA-210991	8.066568e-01	0.093	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.066568e-01	0.093	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.066568e-01	0.093	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.079086e-01	0.093	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.079086e-01	0.093	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.099895e-01	0.092	0	0
HIV Infection	R-HSA-162906	8.108356e-01	0.091	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	8.110070e-01	0.091	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	8.110070e-01	0.091	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	8.110070e-01	0.091	0	0
Disinhibition of SNARE formation	R-HSA-114516	8.110070e-01	0.091	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	8.110070e-01	0.091	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	8.110070e-01	0.091	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	8.110070e-01	0.091	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	8.110070e-01	0.091	0	0
VLDL clearance	R-HSA-8964046	8.110070e-01	0.091	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	8.110070e-01	0.091	0	0
Activation of TRKA receptors	R-HSA-187015	8.110070e-01	0.091	0	0
Glycoprotein hormones	R-HSA-209822	8.110070e-01	0.091	0	0
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	R-HSA-9026762	8.110070e-01	0.091	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	8.110070e-01	0.091	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.110257e-01	0.091	0	0
Mitophagy	R-HSA-5205647	8.111502e-01	0.091	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	8.111502e-01	0.091	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.163714e-01	0.088	0	0
Pyroptosis	R-HSA-5620971	8.163714e-01	0.088	0	0
Inositol phosphate metabolism	R-HSA-1483249	8.193252e-01	0.087	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.214647e-01	0.085	0	0
Metal ion SLC transporters	R-HSA-425410	8.218721e-01	0.085	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.218968e-01	0.085	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.234934e-01	0.084	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.234934e-01	0.084	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.236134e-01	0.084	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.238705e-01	0.084	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.242825e-01	0.084	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.242825e-01	0.084	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.242825e-01	0.084	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.242825e-01	0.084	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.242825e-01	0.084	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	8.242825e-01	0.084	0	0
p38MAPK events	R-HSA-171007	8.242825e-01	0.084	0	0
DNA Damage Reversal	R-HSA-73942	8.242825e-01	0.084	0	0
Signaling by NOTCH1	R-HSA-1980143	8.243773e-01	0.084	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.263119e-01	0.083	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.263119e-01	0.083	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.263119e-01	0.083	0	0
Signaling by PDGFR in disease	R-HSA-9671555	8.263119e-01	0.083	0	0
Assembly Of The HIV Virion	R-HSA-175474	8.263119e-01	0.083	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.266376e-01	0.083	0	0
Selenocysteine synthesis	R-HSA-2408557	8.325700e-01	0.080	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.332048e-01	0.079	0	0
mRNA Capping	R-HSA-72086	8.332048e-01	0.079	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.332048e-01	0.079	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.339498e-01	0.079	0	0
COPII-mediated vesicle transport	R-HSA-204005	8.342422e-01	0.079	0	0
Degradation of CDH1	R-HSA-9766229	8.350285e-01	0.078	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.373863e-01	0.077	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	8.400201e-01	0.076	0	0
Minus-strand DNA synthesis	R-HSA-164516	8.400201e-01	0.076	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.400201e-01	0.076	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	8.400201e-01	0.076	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	8.400201e-01	0.076	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	8.400201e-01	0.076	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	8.400201e-01	0.076	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	8.400201e-01	0.076	0	0
Interleukin-9 signaling	R-HSA-8985947	8.400201e-01	0.076	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	8.400201e-01	0.076	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.400201e-01	0.076	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	8.400201e-01	0.076	0	0
TGFBR3 PTM regulation	R-HSA-9839383	8.400201e-01	0.076	0	0
Alpha-defensins	R-HSA-1462054	8.400201e-01	0.076	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	8.400201e-01	0.076	0	0
HSF1 activation	R-HSA-3371511	8.416205e-01	0.075	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.442297e-01	0.074	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	8.442297e-01	0.074	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.442297e-01	0.074	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.442297e-01	0.074	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.442297e-01	0.074	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	8.442297e-01	0.074	0	0
Signaling by KIT in disease	R-HSA-9669938	8.442297e-01	0.074	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.449947e-01	0.073	0	0
Ion transport by P-type ATPases	R-HSA-936837	8.450217e-01	0.073	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.453142e-01	0.073	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.453142e-01	0.073	0	0
Regulation of BACH1 activity	R-HSA-9708530	8.453142e-01	0.073	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.453142e-01	0.073	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	8.453142e-01	0.073	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.487297e-01	0.071	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	8.497549e-01	0.071	0	0
Viral mRNA Translation	R-HSA-192823	8.504948e-01	0.070	0	0
Potential therapeutics for SARS	R-HSA-9679191	8.522216e-01	0.069	0	0
HCMV Late Events	R-HSA-9610379	8.546688e-01	0.068	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	8.581243e-01	0.066	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.605207e-01	0.065	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.605207e-01	0.065	0	0
Formation of the ureteric bud	R-HSA-9830674	8.605207e-01	0.065	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.625175e-01	0.064	0	0
DAP12 interactions	R-HSA-2172127	8.625175e-01	0.064	0	0
Amine ligand-binding receptors	R-HSA-375280	8.625175e-01	0.064	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.630134e-01	0.064	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.630134e-01	0.064	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	8.640313e-01	0.063	0	0
Passive transport by Aquaporins	R-HSA-432047	8.640313e-01	0.063	0	0
Synthesis of PG	R-HSA-1483148	8.640313e-01	0.063	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.640313e-01	0.063	0	0
PKR-mediated signaling	R-HSA-9833482	8.645613e-01	0.063	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.645806e-01	0.063	0	0
Interleukin-21 signaling	R-HSA-9020958	8.645806e-01	0.063	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.645806e-01	0.063	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	8.645806e-01	0.063	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	8.645806e-01	0.063	0	0
p75NTR regulates axonogenesis	R-HSA-193697	8.645806e-01	0.063	0	0
Regulation of signaling by NODAL	R-HSA-1433617	8.645806e-01	0.063	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.645806e-01	0.063	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.645806e-01	0.063	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	8.645806e-01	0.063	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.645806e-01	0.063	0	0
Signaling by FGFR	R-HSA-190236	8.659439e-01	0.063	0	0
HCMV Infection	R-HSA-9609646	8.710023e-01	0.060	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.733730e-01	0.059	0	0
Fanconi Anemia Pathway	R-HSA-6783310	8.738253e-01	0.059	0	0
Kidney development	R-HSA-9830369	8.751915e-01	0.058	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.752957e-01	0.058	0	0
TNFs bind their physiological receptors	R-HSA-5669034	8.752957e-01	0.058	0	0
Mitochondrial biogenesis	R-HSA-1592230	8.764885e-01	0.057	0	0
GABA receptor activation	R-HSA-977443	8.771409e-01	0.057	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.800787e-01	0.055	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.806488e-01	0.055	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	8.806488e-01	0.055	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.843437e-01	0.053	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.843437e-01	0.053	0	0
PPARA activates gene expression	R-HSA-1989781	8.844956e-01	0.053	0	0
Binding and entry of HIV virion	R-HSA-173107	8.853718e-01	0.053	0	0
MAPK3 (ERK1) activation	R-HSA-110056	8.853718e-01	0.053	0	0
2-LTR circle formation	R-HSA-164843	8.853718e-01	0.053	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.853718e-01	0.053	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.853718e-01	0.053	0	0
Formation of intermediate mesoderm	R-HSA-9761174	8.853718e-01	0.053	0	0
Pexophagy	R-HSA-9664873	8.853718e-01	0.053	0	0
Maturation of spike protein	R-HSA-9683686	8.853718e-01	0.053	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.853718e-01	0.053	0	0
Sperm Motility And Taxes	R-HSA-1300642	8.853718e-01	0.053	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.853718e-01	0.053	0	0
Peptide hormone biosynthesis	R-HSA-209952	8.853718e-01	0.053	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	8.863616e-01	0.052	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.881366e-01	0.052	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.886650e-01	0.051	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.886650e-01	0.051	0	0
G protein gated Potassium channels	R-HSA-1296059	8.886650e-01	0.051	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	8.886650e-01	0.051	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.886650e-01	0.051	0	0
Acyl chain remodelling of PS	R-HSA-1482801	8.886650e-01	0.051	0	0
Laminin interactions	R-HSA-3000157	8.886650e-01	0.051	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.886650e-01	0.051	0	0
Hyaluronan degradation	R-HSA-2160916	8.886650e-01	0.051	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.904350e-01	0.050	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.904350e-01	0.050	0	0
Glycogen metabolism	R-HSA-8982491	8.904350e-01	0.050	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	8.904350e-01	0.050	0	0
Ion channel transport	R-HSA-983712	8.921418e-01	0.050	1	0
FGFR1 ligand binding and activation	R-HSA-190242	8.953700e-01	0.048	0	0
Tie2 Signaling	R-HSA-210993	8.953700e-01	0.048	0	0
Platelet sensitization by LDL	R-HSA-432142	8.953700e-01	0.048	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.953700e-01	0.048	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.957447e-01	0.048	0	0
Downstream TCR signaling	R-HSA-202424	8.961657e-01	0.048	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	8.981592e-01	0.047	0	0
Translation of Structural Proteins	R-HSA-9694635	8.984369e-01	0.047	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.984515e-01	0.047	0	0
Signaling by NOTCH3	R-HSA-9012852	8.984515e-01	0.047	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.991164e-01	0.046	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.991164e-01	0.046	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.991164e-01	0.046	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.003963e-01	0.046	0	0
Maturation of spike protein	R-HSA-9694548	9.003963e-01	0.046	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.007361e-01	0.045	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.007361e-01	0.045	0	0
Platelet degranulation	R-HSA-114608	9.025270e-01	0.045	0	0
DAG1 core M3 glycosylations	R-HSA-8932505	9.029718e-01	0.044	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	9.029718e-01	0.044	0	0
FGFR2b ligand binding and activation	R-HSA-190377	9.029718e-01	0.044	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	9.029718e-01	0.044	0	0
vRNP Assembly	R-HSA-192905	9.029718e-01	0.044	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	9.029718e-01	0.044	0	0
vRNA Synthesis	R-HSA-192814	9.029718e-01	0.044	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	9.029718e-01	0.044	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	9.029718e-01	0.044	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	9.029718e-01	0.044	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	9.029718e-01	0.044	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	9.029718e-01	0.044	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.030619e-01	0.044	0	0
Diseases of hemostasis	R-HSA-9671793	9.083854e-01	0.042	0	0
Influenza Infection	R-HSA-168255	9.089859e-01	0.041	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.091342e-01	0.041	0	0
Hyaluronan metabolism	R-HSA-2142845	9.091342e-01	0.041	0	0
Signaling by NOTCH2	R-HSA-1980145	9.091342e-01	0.041	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.095606e-01	0.041	0	0
Translation of Structural Proteins	R-HSA-9683701	9.095606e-01	0.041	0	0
Signaling by BMP	R-HSA-201451	9.116131e-01	0.040	0	0
Insulin processing	R-HSA-264876	9.116131e-01	0.040	0	0
Signaling by Insulin receptor	R-HSA-74752	9.155950e-01	0.038	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	9.178704e-01	0.037	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	9.178704e-01	0.037	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	9.178704e-01	0.037	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	9.178704e-01	0.037	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	9.178704e-01	0.037	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	9.178704e-01	0.037	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	9.178704e-01	0.037	0	0
DS-GAG biosynthesis	R-HSA-2022923	9.178704e-01	0.037	0	0
GABA B receptor activation	R-HSA-977444	9.179773e-01	0.037	0	0
Activation of GABAB receptors	R-HSA-991365	9.179773e-01	0.037	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.182574e-01	0.037	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.182574e-01	0.037	0	0
Neutrophil degranulation	R-HSA-6798695	9.186345e-01	0.037	0	0
Regulation of RAS by GAPs	R-HSA-5658442	9.192852e-01	0.037	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.192852e-01	0.037	0	0
Cellular response to chemical stress	R-HSA-9711123	9.197883e-01	0.036	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.198717e-01	0.036	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.198717e-01	0.036	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.213953e-01	0.036	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.228423e-01	0.035	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	9.231711e-01	0.035	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.233205e-01	0.035	0	0
Developmental Cell Lineages	R-HSA-9734767	9.255091e-01	0.034	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.256947e-01	0.034	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	9.264281e-01	0.033	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.265514e-01	0.033	0	0
Glycosphingolipid transport	R-HSA-9845576	9.265514e-01	0.033	0	0
Triglyceride metabolism	R-HSA-8979227	9.280995e-01	0.032	0	0
Regulation of beta-cell development	R-HSA-186712	9.280995e-01	0.032	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.299915e-01	0.032	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.299915e-01	0.032	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.299915e-01	0.032	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.299915e-01	0.032	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	9.304820e-01	0.031	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	9.304820e-01	0.031	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.304820e-01	0.031	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	9.304820e-01	0.031	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	9.304820e-01	0.031	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	9.304820e-01	0.031	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	9.304820e-01	0.031	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.305466e-01	0.031	0	0
Cellular response to starvation	R-HSA-9711097	9.320404e-01	0.031	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.330084e-01	0.030	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.340790e-01	0.030	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.355854e-01	0.029	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.380479e-01	0.028	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.388936e-01	0.027	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.388936e-01	0.027	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.390618e-01	0.027	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.392176e-01	0.027	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.392176e-01	0.027	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.392176e-01	0.027	0	0
Leishmania infection	R-HSA-9658195	9.394150e-01	0.027	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.394150e-01	0.027	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.398586e-01	0.027	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.409000e-01	0.026	0	0
FGFR2c ligand binding and activation	R-HSA-190375	9.411577e-01	0.026	0	0
FGFR4 ligand binding and activation	R-HSA-190322	9.411577e-01	0.026	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.411577e-01	0.026	0	0
Acetylcholine binding and downstream events	R-HSA-181431	9.411577e-01	0.026	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.411577e-01	0.026	0	0
Chylomicron remodeling	R-HSA-8963901	9.411577e-01	0.026	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	9.411577e-01	0.026	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.411577e-01	0.026	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	9.411577e-01	0.026	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	9.411577e-01	0.026	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.411577e-01	0.026	0	0
Interleukin-6 signaling	R-HSA-1059683	9.411577e-01	0.026	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	9.411577e-01	0.026	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.433605e-01	0.025	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	9.439284e-01	0.025	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.446229e-01	0.025	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.450736e-01	0.025	0	0
Mitochondrial protein import	R-HSA-1268020	9.450736e-01	0.025	0	0
Signaling by PDGF	R-HSA-186797	9.450736e-01	0.025	0	0
tRNA processing in the nucleus	R-HSA-6784531	9.450736e-01	0.025	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.450905e-01	0.025	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.451120e-01	0.025	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.451120e-01	0.025	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.467132e-01	0.024	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.467132e-01	0.024	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.467132e-01	0.024	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.467132e-01	0.024	0	0
Stabilization of p53	R-HSA-69541	9.470714e-01	0.024	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.470714e-01	0.024	0	0
Host Interactions of HIV factors	R-HSA-162909	9.483919e-01	0.023	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.501944e-01	0.022	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.501944e-01	0.022	0	0
FGFR3c ligand binding and activation	R-HSA-190372	9.501944e-01	0.022	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.501944e-01	0.022	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	9.501944e-01	0.022	0	0
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	9.501944e-01	0.022	0	0
Physiological factors	R-HSA-5578768	9.501944e-01	0.022	0	0
Hydrolysis of LPC	R-HSA-1483115	9.501944e-01	0.022	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.501944e-01	0.022	0	0
Malate-aspartate shuttle	R-HSA-9856872	9.501944e-01	0.022	0	0
Ciprofloxacin ADME	R-HSA-9793528	9.501944e-01	0.022	0	0
Non-canonical inflammasome activation	R-HSA-9686114	9.501944e-01	0.022	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	9.501944e-01	0.022	0	0
Zinc transporters	R-HSA-435354	9.501944e-01	0.022	0	0
P2Y receptors	R-HSA-417957	9.501944e-01	0.022	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.501944e-01	0.022	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.504845e-01	0.022	0	0
Protein folding	R-HSA-391251	9.511194e-01	0.022	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.526469e-01	0.021	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.526469e-01	0.021	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.535728e-01	0.021	0	0
Carnitine shuttle	R-HSA-200425	9.535728e-01	0.021	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.535728e-01	0.021	0	0
Growth hormone receptor signaling	R-HSA-982772	9.535728e-01	0.021	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.548199e-01	0.020	0	0
Platelet homeostasis	R-HSA-418346	9.550027e-01	0.020	0	0
Intraflagellar transport	R-HSA-5620924	9.553747e-01	0.020	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.578437e-01	0.019	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.578437e-01	0.019	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	9.578437e-01	0.019	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	9.578437e-01	0.019	0	0
Translesion synthesis by REV1	R-HSA-110312	9.578437e-01	0.019	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	9.578437e-01	0.019	0	0
Signaling by Activin	R-HSA-1502540	9.578437e-01	0.019	0	0
Biotin transport and metabolism	R-HSA-196780	9.578437e-01	0.019	0	0
FGFR3 ligand binding and activation	R-HSA-190239	9.578437e-01	0.019	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.578437e-01	0.019	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.578437e-01	0.019	0	0
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	9.578437e-01	0.019	0	0
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.578437e-01	0.019	0	0
Interferon gamma signaling	R-HSA-877300	9.579343e-01	0.019	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.593177e-01	0.018	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.595828e-01	0.018	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.595828e-01	0.018	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.595828e-01	0.018	0	0
Signaling by NOTCH4	R-HSA-9013694	9.622335e-01	0.017	0	0
Translesion synthesis by POLI	R-HSA-5656121	9.643186e-01	0.016	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	9.643186e-01	0.016	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.643186e-01	0.016	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.643186e-01	0.016	0	0
Activation of SMO	R-HSA-5635838	9.643186e-01	0.016	0	0
Fructose catabolism	R-HSA-70350	9.643186e-01	0.016	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.643186e-01	0.016	0	0
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.643186e-01	0.016	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.643186e-01	0.016	0	0
Atorvastatin ADME	R-HSA-9754706	9.643186e-01	0.016	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.661573e-01	0.015	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.662867e-01	0.015	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.664479e-01	0.015	0	0
eNOS activation	R-HSA-203615	9.664479e-01	0.015	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.664479e-01	0.015	0	0
The phototransduction cascade	R-HSA-2514856	9.675153e-01	0.014	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.681010e-01	0.014	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.694124e-01	0.013	0	0
Abacavir ADME	R-HSA-2161522	9.694401e-01	0.013	0	0
Translesion synthesis by POLK	R-HSA-5655862	9.697993e-01	0.013	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.697993e-01	0.013	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.697993e-01	0.013	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.697993e-01	0.013	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.697993e-01	0.013	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.697993e-01	0.013	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	9.697993e-01	0.013	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.697993e-01	0.013	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.708297e-01	0.013	0	0
G alpha (s) signalling events	R-HSA-418555	9.709211e-01	0.013	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.717440e-01	0.012	0	0
Surfactant metabolism	R-HSA-5683826	9.732412e-01	0.012	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.734552e-01	0.012	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.734552e-01	0.012	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.734552e-01	0.012	0	0
Ribosome-associated quality control	R-HSA-9948299	9.736866e-01	0.012	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.738282e-01	0.012	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.738327e-01	0.012	0	0
Interleukin-10 signaling	R-HSA-6783783	9.738611e-01	0.012	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.739134e-01	0.011	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.739134e-01	0.011	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.739134e-01	0.011	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.740614e-01	0.011	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.744385e-01	0.011	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.744385e-01	0.011	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.744385e-01	0.011	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.744385e-01	0.011	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.744385e-01	0.011	0	0
Glycogen storage diseases	R-HSA-3229121	9.744385e-01	0.011	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	9.744385e-01	0.011	0	0
Catecholamine biosynthesis	R-HSA-209905	9.744385e-01	0.011	0	0
Choline catabolism	R-HSA-6798163	9.744385e-01	0.011	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.744385e-01	0.011	0	0
SARS-CoV Infections	R-HSA-9679506	9.752598e-01	0.011	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.761907e-01	0.010	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.763592e-01	0.010	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.769582e-01	0.010	0	0
Insulin receptor recycling	R-HSA-77387	9.769582e-01	0.010	0	0
Pyrimidine salvage	R-HSA-73614	9.769582e-01	0.010	0	0
Degradation of AXIN	R-HSA-4641257	9.770262e-01	0.010	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.770262e-01	0.010	0	0
Degradation of DVL	R-HSA-4641258	9.770262e-01	0.010	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.770262e-01	0.010	0	0
NCAM1 interactions	R-HSA-419037	9.770262e-01	0.010	0	0
Metabolism of folate and pterines	R-HSA-196757	9.770262e-01	0.010	0	0
Leishmania phagocytosis	R-HSA-9664417	9.772175e-01	0.010	0	0
Parasite infection	R-HSA-9664407	9.772175e-01	0.010	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.772175e-01	0.010	0	0
Interferon Signaling	R-HSA-913531	9.778586e-01	0.010	0	0
Phospholipid metabolism	R-HSA-1483257	9.782674e-01	0.010	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.783652e-01	0.009	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.783652e-01	0.009	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.783652e-01	0.009	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.783652e-01	0.009	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.783652e-01	0.009	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	9.783652e-01	0.009	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.783652e-01	0.009	0	0
Biosynthesis of DHA-derived sulfido conjugates	R-HSA-9026395	9.783652e-01	0.009	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.783652e-01	0.009	0	0
Nephron development	R-HSA-9831926	9.783652e-01	0.009	0	0
G alpha (z) signalling events	R-HSA-418597	9.789839e-01	0.009	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.797832e-01	0.009	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.800117e-01	0.009	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.816889e-01	0.008	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.816889e-01	0.008	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.816889e-01	0.008	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.816889e-01	0.008	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.816889e-01	0.008	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.816889e-01	0.008	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.817627e-01	0.008	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.826709e-01	0.008	0	0
Neurotransmitter clearance	R-HSA-112311	9.826709e-01	0.008	0	0
Neurotransmitter release cycle	R-HSA-112310	9.834480e-01	0.007	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.836045e-01	0.007	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.840468e-01	0.007	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.845022e-01	0.007	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.845022e-01	0.007	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.845022e-01	0.007	0	0
Glycogen synthesis	R-HSA-3322077	9.845022e-01	0.007	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.845022e-01	0.007	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.845022e-01	0.007	0	0
RSV-host interactions	R-HSA-9833110	9.847606e-01	0.007	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.849851e-01	0.007	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.849851e-01	0.007	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.851941e-01	0.006	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.862834e-01	0.006	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.862834e-01	0.006	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.865004e-01	0.006	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.868834e-01	0.006	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.868834e-01	0.006	0	0
G-protein activation	R-HSA-202040	9.868834e-01	0.006	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.868834e-01	0.006	0	0
Phenylalanine metabolism	R-HSA-8964208	9.868834e-01	0.006	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.868834e-01	0.006	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.868834e-01	0.006	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.868834e-01	0.006	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.868834e-01	0.006	0	0
Immune System	R-HSA-168256	9.878011e-01	0.005	0	0
Glutathione conjugation	R-HSA-156590	9.880176e-01	0.005	0	0
PCP/CE pathway	R-HSA-4086400	9.884995e-01	0.005	0	0
Integrin cell surface interactions	R-HSA-216083	9.884995e-01	0.005	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.887459e-01	0.005	0	0
Attachment and Entry	R-HSA-9694614	9.888988e-01	0.005	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.888988e-01	0.005	0	0
Serine metabolism	R-HSA-977347	9.888988e-01	0.005	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.888988e-01	0.005	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.890759e-01	0.005	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.897019e-01	0.004	0	0
Collagen formation	R-HSA-1474290	9.897019e-01	0.004	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.902642e-01	0.004	0	0
Heme degradation	R-HSA-189483	9.902642e-01	0.004	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.906046e-01	0.004	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.906046e-01	0.004	0	0
Cellular hexose transport	R-HSA-189200	9.906046e-01	0.004	0	0
Fructose metabolism	R-HSA-5652084	9.906046e-01	0.004	0	0
LDL clearance	R-HSA-8964038	9.906046e-01	0.004	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.907498e-01	0.004	0	0
rRNA processing	R-HSA-72312	9.912162e-01	0.004	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.915085e-01	0.004	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.915818e-01	0.004	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.915818e-01	0.004	0	0
Signal amplification	R-HSA-392518	9.915818e-01	0.004	0	0
Gap junction trafficking	R-HSA-190828	9.918982e-01	0.004	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.920484e-01	0.003	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.920484e-01	0.003	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.920484e-01	0.003	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.920484e-01	0.003	0	0
Biosynthesis of maresins	R-HSA-9018682	9.920484e-01	0.003	0	0
Protein localization	R-HSA-9609507	9.921563e-01	0.003	0	0
Hemostasis	R-HSA-109582	9.922717e-01	0.003	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.927244e-01	0.003	0	0
Regulation of Apoptosis	R-HSA-169911	9.927244e-01	0.003	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.927244e-01	0.003	0	0
PERK regulates gene expression	R-HSA-381042	9.927244e-01	0.003	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.927244e-01	0.003	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.929082e-01	0.003	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.932036e-01	0.003	0	0
GPCR downstream signalling	R-HSA-388396	9.932261e-01	0.003	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.932704e-01	0.003	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.932704e-01	0.003	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.932704e-01	0.003	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.932704e-01	0.003	0	0
Complex III assembly	R-HSA-9865881	9.932704e-01	0.003	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.932704e-01	0.003	0	0
Cellular response to hypoxia	R-HSA-1234174	9.932853e-01	0.003	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.937147e-01	0.003	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.937248e-01	0.003	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.938676e-01	0.003	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.943047e-01	0.002	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.943047e-01	0.002	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.943047e-01	0.002	0	0
Fertilization	R-HSA-1187000	9.943047e-01	0.002	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.943047e-01	0.002	0	0
UCH proteinases	R-HSA-5689603	9.945198e-01	0.002	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.945725e-01	0.002	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.945725e-01	0.002	0	0
Collagen chain trimerization	R-HSA-8948216	9.945725e-01	0.002	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.945753e-01	0.002	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.946972e-01	0.002	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.951170e-01	0.002	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.951801e-01	0.002	0	0
Urea cycle	R-HSA-70635	9.951801e-01	0.002	0	0
Sphingolipid catabolism	R-HSA-9845614	9.951801e-01	0.002	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.951801e-01	0.002	0	0
Suppression of phagosomal maturation	R-HSA-9637687	9.951801e-01	0.002	0	0
SLC transporter disorders	R-HSA-5619102	9.952383e-01	0.002	0	0
Gluconeogenesis	R-HSA-70263	9.952593e-01	0.002	0	0
Peroxisomal protein import	R-HSA-9033241	9.956963e-01	0.002	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.956963e-01	0.002	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.958593e-01	0.002	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.959209e-01	0.002	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.959209e-01	0.002	0	0
Triglyceride biosynthesis	R-HSA-75109	9.959209e-01	0.002	0	0
Synthesis of PE	R-HSA-1483213	9.959209e-01	0.002	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.959209e-01	0.002	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.959209e-01	0.002	0	0
Pentose phosphate pathway	R-HSA-71336	9.959579e-01	0.002	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.959579e-01	0.002	0	0
RAS processing	R-HSA-9648002	9.959579e-01	0.002	0	0
tRNA Aminoacylation	R-HSA-379724	9.962090e-01	0.002	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.965137e-01	0.002	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.965137e-01	0.002	0	0
Prednisone ADME	R-HSA-9757110	9.965479e-01	0.002	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.965479e-01	0.002	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.966623e-01	0.001	0	0
Collagen degradation	R-HSA-1442490	9.966623e-01	0.001	0	0
ECM proteoglycans	R-HSA-3000178	9.967155e-01	0.001	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.968457e-01	0.001	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.969942e-01	0.001	0	0
Thyroxine biosynthesis	R-HSA-209968	9.970786e-01	0.001	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.970786e-01	0.001	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.970786e-01	0.001	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.970786e-01	0.001	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.970786e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.972739e-01	0.001	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.974094e-01	0.001	0	0
Neddylation	R-HSA-8951664	9.977384e-01	0.001	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.979078e-01	0.001	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.979078e-01	0.001	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.979697e-01	0.001	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.979995e-01	0.001	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.980775e-01	0.001	0	0
Paracetamol ADME	R-HSA-9753281	9.981797e-01	0.001	0	0
DAG1 glycosylations	R-HSA-8931838	9.982295e-01	0.001	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.982295e-01	0.001	0	0
HS-GAG degradation	R-HSA-2024096	9.982295e-01	0.001	0	0
Proteasome assembly	R-HSA-9907900	9.983447e-01	0.001	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.984152e-01	0.001	0	0
Recycling of bile acids and salts	R-HSA-159418	9.985017e-01	0.001	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.985017e-01	0.001	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.985752e-01	0.001	0	0
Somitogenesis	R-HSA-9824272	9.985752e-01	0.001	0	0
ABC transporter disorders	R-HSA-5619084	9.986080e-01	0.001	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.986504e-01	0.001	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.987321e-01	0.001	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.987711e-01	0.001	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.989271e-01	0.000	0	0
Gap junction assembly	R-HSA-190861	9.989271e-01	0.000	0	0
Synthesis of PC	R-HSA-1483191	9.989453e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.989624e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.990907e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.990907e-01	0.000	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.990921e-01	0.000	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.990921e-01	0.000	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.990921e-01	0.000	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.990921e-01	0.000	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.990929e-01	0.000	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.990930e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.992011e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.992119e-01	0.000	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.992201e-01	0.000	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.992317e-01	0.000	0	0
Azathioprine ADME	R-HSA-9748787	9.993297e-01	0.000	0	0
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.993499e-01	0.000	0	0
Lysine catabolism	R-HSA-71064	9.993499e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.993897e-01	0.000	0	0
Complex IV assembly	R-HSA-9864848	9.994240e-01	0.000	0	0
Purine salvage	R-HSA-74217	9.994499e-01	0.000	0	0
Elastic fibre formation	R-HSA-1566948	9.994499e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.994660e-01	0.000	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.995345e-01	0.000	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.995345e-01	0.000	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.995345e-01	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	9.995425e-01	0.000	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.995749e-01	0.000	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.996061e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.996632e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.996632e-01	0.000	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.996667e-01	0.000	0	0
ER-Phagosome pathway	R-HSA-1236974	9.996964e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.997129e-01	0.000	0	0
Heme biosynthesis	R-HSA-189451	9.997180e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.997204e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.997204e-01	0.000	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.997519e-01	0.000	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.997614e-01	0.000	0	0
Dectin-2 family	R-HSA-5621480	9.997692e-01	0.000	0	0
Synthesis of PA	R-HSA-1483166	9.997692e-01	0.000	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.997822e-01	0.000	0	0
Defensins	R-HSA-1461973	9.997981e-01	0.000	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.998292e-01	0.000	0	0
Methylation	R-HSA-156581	9.998292e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.998356e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.998426e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.998472e-01	0.000	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.998554e-01	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.998648e-01	0.000	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.998777e-01	0.000	0	0
Iron uptake and transport	R-HSA-917937	9.998934e-01	0.000	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.998955e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999087e-01	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.999173e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999173e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999207e-01	0.000	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.999373e-01	0.000	0	0
tRNA processing	R-HSA-72306	9.999384e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999399e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999417e-01	0.000	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.999470e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999505e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.999576e-01	0.000	0	0
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.999728e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.999734e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.999734e-01	0.000	0	0
Digestion	R-HSA-8935690	9.999770e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999805e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999825e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.999833e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.999841e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999852e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.999861e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999870e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999873e-01	0.000	0	0
Metabolism of polyamines	R-HSA-351202	9.999882e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.999900e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.999911e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.999911e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999924e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.999929e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999940e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999943e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999944e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999944e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999949e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999965e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999969e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999978e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999980e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999980e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.999984e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999989e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999992e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999992e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999996e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999997e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999997e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999997e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999998e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999999e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999999e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999999e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	1.000000e+00	0.000	0	0
FCGR activation	R-HSA-2029481	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000	0	0
Translation	R-HSA-72766	1.000000e+00	0.000	0	0
Keratinization	R-HSA-6805567	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	1	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cellular response to heat stress	R-HSA-3371556	9.048318e-14	13.043	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.852962e-12	11.732	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.462741e-11	10.263	0	0
Attenuation phase	R-HSA-3371568	6.838741e-11	10.165	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.087129e-10	9.092	0	0
Cell Cycle	R-HSA-1640170	1.660385e-09	8.780	0	0
HSF1 activation	R-HSA-3371511	2.232510e-09	8.651	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	8.215299e-09	8.085	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.826759e-08	7.738	0	0
Chromatin modifying enzymes	R-HSA-3247509	2.893207e-08	7.539	0	0
Chromatin organization	R-HSA-4839726	3.339861e-08	7.476	0	0
Signal Transduction	R-HSA-162582	3.699300e-08	7.432	1	0
Intracellular signaling by second messengers	R-HSA-9006925	7.006646e-08	7.154	1	0
M Phase	R-HSA-68886	9.951071e-08	7.002	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.453232e-07	6.838	0	0
HATs acetylate histones	R-HSA-3214847	4.687657e-07	6.329	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.699545e-07	6.244	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.489376e-06	5.827	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.688605e-06	5.772	0	0
Apoptotic execution phase	R-HSA-75153	1.719953e-06	5.764	0	0
Meiotic synapsis	R-HSA-1221632	2.649165e-06	5.577	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.833706e-06	5.548	0	0
Cellular responses to stimuli	R-HSA-8953897	2.815234e-06	5.550	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.996862e-06	5.523	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.047373e-06	5.393	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.147007e-06	5.288	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.419375e-06	5.266	0	0
Cellular Senescence	R-HSA-2559583	5.212885e-06	5.283	0	0
PIP3 activates AKT signaling	R-HSA-1257604	8.711890e-06	5.060	1	1
Cellular responses to stress	R-HSA-2262752	8.894918e-06	5.051	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.064305e-05	4.973	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.115308e-05	4.953	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.307659e-05	4.884	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.588375e-05	4.799	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.630435e-05	4.788	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.897077e-05	4.722	0	0
Nucleosome assembly	R-HSA-774815	1.897077e-05	4.722	0	0
Mitotic Prophase	R-HSA-68875	2.082161e-05	4.681	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.602038e-05	4.585	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.732307e-05	4.563	0	0
p75NTR recruits signalling complexes	R-HSA-209543	2.860600e-05	4.544	0	0
Death Receptor Signaling	R-HSA-73887	3.151081e-05	4.502	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	3.556994e-05	4.449	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.937351e-05	4.405	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.029542e-05	4.395	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	5.133686e-05	4.290	0	0
Mitotic Anaphase	R-HSA-68882	5.379946e-05	4.269	0	0
Regulation of PTEN localization	R-HSA-8948747	5.749729e-05	4.240	0	0
Deubiquitination	R-HSA-5688426	5.727871e-05	4.242	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.902885e-05	4.229	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.050093e-05	4.218	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	6.284182e-05	4.202	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	7.362344e-05	4.133	0	0
mRNA 3'-end processing	R-HSA-72187	8.524302e-05	4.069	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	8.893656e-05	4.051	0	0
Mitotic Prometaphase	R-HSA-68877	9.625785e-05	4.017	0	0
Packaging Of Telomere Ends	R-HSA-171306	9.803864e-05	4.009	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.046976e-04	3.980	0	0
Meiosis	R-HSA-1500620	1.165223e-04	3.934	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.166024e-04	3.933	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.342347e-04	3.872	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.350995e-04	3.869	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.350995e-04	3.869	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.315753e-04	3.881	0	0
Chromosome Maintenance	R-HSA-73886	1.365297e-04	3.865	0	0
mRNA Splicing	R-HSA-72172	1.447099e-04	3.840	0	0
HDACs deacetylate histones	R-HSA-3214815	1.507532e-04	3.822	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.474833e-04	3.831	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.543699e-04	3.811	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.671154e-04	3.777	0	0
ESR-mediated signaling	R-HSA-8939211	1.723846e-04	3.764	0	0
Protein ubiquitination	R-HSA-8852135	1.837221e-04	3.736	0	0
NRAGE signals death through JNK	R-HSA-193648	1.807311e-04	3.743	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.878285e-04	3.726	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.942023e-04	3.712	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.980888e-04	3.703	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.612609e-04	3.583	0	0
Ub-specific processing proteases	R-HSA-5689880	2.515714e-04	3.599	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.688149e-04	3.571	0	0
PRC2 methylates histones and DNA	R-HSA-212300	3.043138e-04	3.517	0	0
Regulation of TP53 Degradation	R-HSA-6804757	3.043138e-04	3.517	1	1
Cell-Cell communication	R-HSA-1500931	2.882439e-04	3.540	0	0
G2/M Checkpoints	R-HSA-69481	3.036958e-04	3.518	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	3.130433e-04	3.504	0	0
Axon guidance	R-HSA-422475	3.147181e-04	3.502	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.151472e-04	3.501	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.587384e-04	3.445	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.490359e-04	3.457	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.769095e-04	3.424	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	3.893756e-04	3.410	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	4.197025e-04	3.377	0	0
G2/M DNA damage checkpoint	R-HSA-69473	4.208378e-04	3.376	0	0
Reproduction	R-HSA-1474165	4.651214e-04	3.332	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.051291e-04	3.297	0	0
Signaling by VEGF	R-HSA-194138	5.351729e-04	3.272	0	0
Nervous system development	R-HSA-9675108	5.376427e-04	3.270	0	0
Cell-extracellular matrix interactions	R-HSA-446353	5.401741e-04	3.267	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.669182e-04	3.246	1	0
FLT3 signaling by CBL mutants	R-HSA-9706377	6.031241e-04	3.220	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	6.192759e-04	3.208	0	0
Cell junction organization	R-HSA-446728	6.179048e-04	3.209	0	0
DNA methylation	R-HSA-5334118	6.289662e-04	3.201	0	0
NF-kB is activated and signals survival	R-HSA-209560	6.560679e-04	3.183	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.591650e-04	3.181	0	0
Regulation of endogenous retroelements	R-HSA-9842860	6.609069e-04	3.180	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.137425e-04	3.146	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	6.839334e-04	3.165	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	7.137425e-04	3.146	0	0
Apoptosis	R-HSA-109581	6.799917e-04	3.167	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.264355e-04	3.139	0	0
Negative regulation of MET activity	R-HSA-6807004	7.537164e-04	3.123	0	0
Telomere Maintenance	R-HSA-157579	8.457022e-04	3.073	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	9.012051e-04	3.045	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	9.104139e-04	3.041	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	9.511444e-04	3.022	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	9.837181e-04	3.007	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	9.837181e-04	3.007	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	9.857217e-04	3.006	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.102761e-03	2.958	1	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.111763e-03	2.954	0	0
MTOR signalling	R-HSA-165159	1.194595e-03	2.923	0	0
Cleavage of the damaged purine	R-HSA-110331	1.222634e-03	2.913	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	1.194595e-03	2.923	0	0
Depyrimidination	R-HSA-73928	1.194595e-03	2.923	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.241210e-03	2.906	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.393404e-03	2.856	0	0
Depurination	R-HSA-73927	1.472027e-03	2.832	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.480135e-03	2.830	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.564478e-03	2.806	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.564478e-03	2.806	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.578872e-03	2.802	0	0
DNA Replication Pre-Initiation	R-HSA-69002	1.588322e-03	2.799	0	0
Josephin domain DUBs	R-HSA-5689877	1.661089e-03	2.780	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.661089e-03	2.780	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.661089e-03	2.780	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.748164e-03	2.757	1	1
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.761941e-03	2.754	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.761941e-03	2.754	0	0
RNA Polymerase I Transcription	R-HSA-73864	1.791952e-03	2.747	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.798918e-03	2.745	0	0
Meiotic recombination	R-HSA-912446	1.833595e-03	2.737	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	1.847899e-03	2.733	0	0
DAG and IP3 signaling	R-HSA-1489509	1.977809e-03	2.704	0	0
Membrane Trafficking	R-HSA-199991	2.040857e-03	2.690	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.172709e-03	2.663	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.097170e-03	2.678	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	2.317935e-03	2.635	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.317935e-03	2.635	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.317935e-03	2.635	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	2.317935e-03	2.635	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.131532e-03	2.671	0	0
Signaling by RAS mutants	R-HSA-6802949	2.317935e-03	2.635	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.298102e-03	2.639	0	0
Signaling by WNT	R-HSA-195721	2.214319e-03	2.655	0	0
Homology Directed Repair	R-HSA-5693538	2.248313e-03	2.648	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.395402e-03	2.621	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.482830e-03	2.605	0	0
PKMTs methylate histone lysines	R-HSA-3214841	2.482830e-03	2.605	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.482830e-03	2.605	0	0
FLT3 Signaling	R-HSA-9607240	2.482830e-03	2.605	0	0
Amyloid fiber formation	R-HSA-977225	2.567259e-03	2.591	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.604457e-03	2.584	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.651215e-03	2.577	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.850166e-03	2.545	0	0
Signaling by ROBO receptors	R-HSA-376176	2.866761e-03	2.543	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.350471e-03	2.475	0	0
Signaling by AXIN mutants	R-HSA-4839735	3.350471e-03	2.475	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	3.350471e-03	2.475	0	0
CaM pathway	R-HSA-111997	3.104502e-03	2.508	0	0
Calmodulin induced events	R-HSA-111933	3.104502e-03	2.508	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.350471e-03	2.475	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.112455e-03	2.507	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.678895e-03	2.434	0	0
Defective pyroptosis	R-HSA-9710421	3.998178e-03	2.398	0	0
Regulation of TP53 Activity	R-HSA-5633007	4.025642e-03	2.395	1	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.252631e-03	2.371	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	4.252631e-03	2.371	0	0
Regulation of CDH1 Function	R-HSA-9764561	4.282987e-03	2.368	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.608922e-03	2.336	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.692866e-03	2.329	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.692866e-03	2.329	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.692866e-03	2.329	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.467788e-03	2.262	0	0
Gene Silencing by RNA	R-HSA-211000	5.633870e-03	2.249	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.755104e-03	2.170	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.755104e-03	2.170	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.755104e-03	2.170	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.755104e-03	2.170	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	6.088541e-03	2.215	0	0
RAF activation	R-HSA-5673000	6.446886e-03	2.191	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.072451e-03	2.217	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.162039e-03	2.210	0	0
ISG15 antiviral mechanism	R-HSA-1169408	6.659658e-03	2.177	0	0
Diseases of programmed cell death	R-HSA-9645723	6.092340e-03	2.215	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.876232e-03	2.163	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.899409e-03	2.161	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.904833e-03	2.161	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.131751e-03	2.147	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	8.585583e-03	2.066	0	0
Signaling by RAF1 mutants	R-HSA-9656223	7.942122e-03	2.100	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.942122e-03	2.100	0	0
Translesion Synthesis by POLH	R-HSA-110320	8.585583e-03	2.066	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.562608e-03	2.067	0	0
Epigenetic regulation of gene expression	R-HSA-212165	8.479389e-03	2.072	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.915382e-03	2.102	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	8.420281e-03	2.075	0	0
Rap1 signalling	R-HSA-392517	8.585583e-03	2.066	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	7.908914e-03	2.102	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	7.915382e-03	2.102	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	7.942122e-03	2.100	0	0
Pexophagy	R-HSA-9664873	8.420281e-03	2.075	0	0
Adherens junctions interactions	R-HSA-418990	8.029787e-03	2.095	0	0
Maturation of protein E	R-HSA-9694493	7.428638e-03	2.129	0	0
Maturation of protein E	R-HSA-9683683	7.428638e-03	2.129	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.932283e-03	2.101	0	0
Oncogenic MAPK signaling	R-HSA-6802957	8.643195e-03	2.063	0	0
FLT3 signaling in disease	R-HSA-9682385	8.808893e-03	2.055	0	0
Semaphorin interactions	R-HSA-373755	8.894900e-03	2.051	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	9.114268e-03	2.040	0	0
Ca-dependent events	R-HSA-111996	9.132098e-03	2.039	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	9.556336e-03	2.020	0	0
EGFR downregulation	R-HSA-182971	9.623554e-03	2.017	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.623554e-03	2.017	0	0
DCC mediated attractive signaling	R-HSA-418885	1.012978e-02	1.994	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.012978e-02	1.994	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.012978e-02	1.994	0	0
Spry regulation of FGF signaling	R-HSA-1295596	1.012978e-02	1.994	0	0
Programmed Cell Death	R-HSA-5357801	1.017730e-02	1.992	0	0
Ovarian tumor domain proteases	R-HSA-5689896	1.021387e-02	1.991	0	0
Long-term potentiation	R-HSA-9620244	1.027246e-02	1.988	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.060770e-02	1.974	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.060770e-02	1.974	0	0
Metabolism of RNA	R-HSA-8953854	1.063975e-02	1.973	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.106032e-02	1.956	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.106032e-02	1.956	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.109506e-02	1.955	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.130692e-02	1.947	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.130692e-02	1.947	0	0
Signaling by APC mutants	R-HSA-4839744	1.130692e-02	1.947	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.130692e-02	1.947	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.130692e-02	1.947	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.130692e-02	1.947	0	0
Post NMDA receptor activation events	R-HSA-438064	1.149254e-02	1.940	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.231299e-02	1.910	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.480293e-02	1.830	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.283644e-02	1.892	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.283644e-02	1.892	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.283644e-02	1.892	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.435856e-02	1.843	0	0
Signaling by ERBB2	R-HSA-1227986	1.435856e-02	1.843	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.240130e-02	1.907	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.443279e-02	1.841	0	0
DNA Replication	R-HSA-69306	1.389956e-02	1.857	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.480293e-02	1.830	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.352778e-02	1.869	0	0
Negative regulation of FLT3	R-HSA-9706369	1.275193e-02	1.894	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.483461e-02	1.829	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.483461e-02	1.829	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.545061e-02	1.811	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.545061e-02	1.811	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.545061e-02	1.811	0	0
Assembly Of The HIV Virion	R-HSA-175474	1.545061e-02	1.811	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.570089e-02	1.804	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.570089e-02	1.804	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.570089e-02	1.804	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.570089e-02	1.804	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.570089e-02	1.804	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.570089e-02	1.804	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.581635e-02	1.801	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.581635e-02	1.801	0	0
PLC beta mediated events	R-HSA-112043	1.597276e-02	1.797	0	0
MAPK family signaling cascades	R-HSA-5683057	1.684627e-02	1.773	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.692045e-02	1.772	0	0
S Phase	R-HSA-69242	1.729949e-02	1.762	0	0
Signaling by NOTCH2	R-HSA-1980145	1.753888e-02	1.756	0	0
mTORC1-mediated signalling	R-HSA-166208	1.842215e-02	1.735	0	0
Cell-cell junction organization	R-HSA-421270	1.871426e-02	1.728	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.133868e-02	1.671	0	0
IRAK1 recruits IKK complex	R-HSA-937039	1.895714e-02	1.722	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.895714e-02	1.722	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.895714e-02	1.722	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.895714e-02	1.722	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.895714e-02	1.722	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.895714e-02	1.722	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.895714e-02	1.722	0	0
Late endosomal microautophagy	R-HSA-9615710	1.970020e-02	1.706	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.009900e-02	1.697	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.992611e-02	1.701	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.992611e-02	1.701	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.248322e-02	1.648	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.339827e-02	1.631	0	0
DNA Damage Bypass	R-HSA-73893	2.170110e-02	1.664	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	1.935530e-02	1.713	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.986384e-02	1.702	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.986384e-02	1.702	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.170110e-02	1.664	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.291832e-02	1.640	0	0
Signaling by EGFR	R-HSA-177929	2.071263e-02	1.684	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.262673e-02	1.645	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	2.133868e-02	1.671	0	0
Signaling by MET	R-HSA-6806834	2.262673e-02	1.645	0	0
TNF signaling	R-HSA-75893	2.071263e-02	1.684	0	0
Glycolysis	R-HSA-70171	2.095435e-02	1.679	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.213126e-02	1.655	1	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.133868e-02	1.671	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.248322e-02	1.648	0	0
Specification of primordial germ cells	R-HSA-9827857	1.935530e-02	1.713	0	0
Sodium/Proton exchangers	R-HSA-425986	2.133868e-02	1.671	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.895205e-02	1.722	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	2.133868e-02	1.671	0	0
Gene expression (Transcription)	R-HSA-74160	2.372193e-02	1.625	1	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.381195e-02	1.623	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.552441e-02	1.593	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.600935e-02	1.585	0	0
Budding and maturation of HIV virion	R-HSA-162588	2.620978e-02	1.582	0	0
Signaling by NOTCH4	R-HSA-9013694	2.663264e-02	1.575	0	0
PTEN Regulation	R-HSA-6807070	2.670047e-02	1.573	0	0
Circadian clock	R-HSA-9909396	2.750113e-02	1.561	0	0
Regulation of signaling by CBL	R-HSA-912631	2.797164e-02	1.553	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.811311e-02	1.551	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.811311e-02	1.551	0	0
Unwinding of DNA	R-HSA-176974	2.811311e-02	1.551	0	0
Autophagy	R-HSA-9612973	2.817939e-02	1.550	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	2.825088e-02	1.549	0	0
G-protein mediated events	R-HSA-112040	2.870441e-02	1.542	0	0
Base Excision Repair	R-HSA-73884	2.897251e-02	1.538	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.940272e-02	1.532	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.940272e-02	1.532	0	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	2.945886e-02	1.531	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.945886e-02	1.531	0	0
NrCAM interactions	R-HSA-447038	2.945886e-02	1.531	0	0
Sema4D in semaphorin signaling	R-HSA-400685	2.969470e-02	1.527	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	2.996889e-02	1.523	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.129024e-02	1.505	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.108310e-02	1.386	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.603018e-02	1.443	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.575743e-02	1.447	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.575743e-02	1.447	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.575743e-02	1.447	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	3.575743e-02	1.447	0	0
Translesion synthesis by POLI	R-HSA-5656121	4.289649e-02	1.368	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	3.309835e-02	1.480	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.935842e-02	1.405	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.935842e-02	1.405	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.048413e-02	1.393	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.048413e-02	1.393	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	3.430107e-02	1.465	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.131655e-02	1.384	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.879764e-02	1.411	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.702766e-02	1.431	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.879764e-02	1.411	0	0
Metalloprotease DUBs	R-HSA-5689901	3.430107e-02	1.465	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.108310e-02	1.386	0	0
Translesion synthesis by REV1	R-HSA-110312	3.575743e-02	1.447	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.408259e-02	1.467	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	4.289649e-02	1.368	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.309835e-02	1.480	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.321789e-02	1.479	0	0
Protein methylation	R-HSA-8876725	3.575743e-02	1.447	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	3.575743e-02	1.447	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	4.289649e-02	1.368	0	0
Protein-protein interactions at synapses	R-HSA-6794362	3.413254e-02	1.467	0	0
Signaling by NOTCH	R-HSA-157118	3.899522e-02	1.409	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	3.399972e-02	1.469	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.108310e-02	1.386	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.108310e-02	1.386	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	3.510432e-02	1.455	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.935842e-02	1.405	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.131655e-02	1.384	0	0
RNA Polymerase II Transcription	R-HSA-73857	3.722714e-02	1.429	1	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.408259e-02	1.467	0	0
Heme signaling	R-HSA-9707616	3.706282e-02	1.431	0	0
Glycogen metabolism	R-HSA-8982491	3.702766e-02	1.431	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	3.561462e-02	1.448	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.879764e-02	1.411	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.408259e-02	1.467	0	0
Dual Incision in GG-NER	R-HSA-5696400	4.342123e-02	1.362	0	0
Nuclear import of Rev protein	R-HSA-180746	4.342123e-02	1.362	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	4.342123e-02	1.362	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.342123e-02	1.362	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.379180e-02	1.359	0	0
RAF/MAP kinase cascade	R-HSA-5673001	4.490088e-02	1.348	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.508492e-02	1.346	0	0
MAP2K and MAPK activation	R-HSA-5674135	4.592842e-02	1.338	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.733029e-02	1.325	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.733029e-02	1.325	0	0
HIV Life Cycle	R-HSA-162587	4.795270e-02	1.319	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.797669e-02	1.319	0	0
Translesion synthesis by POLK	R-HSA-5655862	5.083273e-02	1.294	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.083273e-02	1.294	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	5.087442e-02	1.294	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	5.197158e-02	1.284	0	0
AURKA Activation by TPX2	R-HSA-8854518	5.205786e-02	1.284	0	0
RET signaling	R-HSA-8853659	5.430639e-02	1.265	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	5.467053e-02	1.262	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.467053e-02	1.262	0	0
Activation of RAC1	R-HSA-428540	5.534136e-02	1.257	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.546033e-02	1.256	0	0
TBC/RABGAPs	R-HSA-8854214	5.614986e-02	1.251	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.735134e-02	1.241	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.735134e-02	1.241	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.825920e-02	1.235	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	5.829318e-02	1.234	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	5.847731e-02	1.233	0	0
Signaling by Hippo	R-HSA-2028269	5.957153e-02	1.225	0	0
Glycogen storage diseases	R-HSA-3229121	5.957153e-02	1.225	0	0
Signaling by NOTCH1	R-HSA-1980143	5.970372e-02	1.224	0	0
Interleukin-12 signaling	R-HSA-9020591	5.970372e-02	1.224	0	0
Degradation of DVL	R-HSA-4641258	6.034747e-02	1.219	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.034747e-02	1.219	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	6.135469e-02	1.212	0	0
EPHB-mediated forward signaling	R-HSA-3928662	6.177109e-02	1.209	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	6.177109e-02	1.209	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.177347e-02	1.209	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.177347e-02	1.209	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.177347e-02	1.209	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.177347e-02	1.209	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.177347e-02	1.209	0	0
Neurexins and neuroligins	R-HSA-6794361	6.213492e-02	1.207	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	6.242057e-02	1.205	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	9.002047e-02	1.046	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	9.002047e-02	1.046	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	9.002047e-02	1.046	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	9.002047e-02	1.046	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	9.002047e-02	1.046	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	9.002047e-02	1.046	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.002047e-02	1.046	0	0
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	9.002047e-02	1.046	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.011676e-02	1.154	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.011676e-02	1.154	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.011676e-02	1.154	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.728942e-02	1.059	0	0
Formation of annular gap junctions	R-HSA-196025	8.728942e-02	1.059	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	6.671922e-02	1.176	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.671922e-02	1.176	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.944266e-02	1.100	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.055127e-02	1.043	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	7.628191e-02	1.118	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	7.628191e-02	1.118	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.431566e-02	1.192	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.431566e-02	1.192	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.560033e-02	1.068	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	7.971596e-02	1.098	0	0
Translation initiation complex formation	R-HSA-72649	7.350146e-02	1.134	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.609046e-02	1.065	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	8.609046e-02	1.065	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.722083e-02	1.059	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	9.155137e-02	1.038	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.379056e-02	1.028	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	6.911106e-02	1.160	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.070976e-02	1.151	0	0
DNA strand elongation	R-HSA-69190	7.177036e-02	1.144	0	0
Aggrephagy	R-HSA-9646399	8.091484e-02	1.092	0	0
Nephrin family interactions	R-HSA-373753	9.055127e-02	1.043	0	0
Nuclear RNA decay	R-HSA-9930044	7.971596e-02	1.098	0	0
Myogenesis	R-HSA-525793	8.560033e-02	1.068	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.072247e-02	1.093	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	8.879230e-02	1.052	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.879230e-02	1.052	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	8.170802e-02	1.088	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.944266e-02	1.100	0	0
Selective autophagy	R-HSA-9663891	8.103685e-02	1.091	0	0
Switching of origins to a post-replicative state	R-HSA-69052	8.722083e-02	1.059	0	0
Neurodegenerative Diseases	R-HSA-8863678	6.756867e-02	1.170	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.756867e-02	1.170	0	0
Glycogen synthesis	R-HSA-3322077	9.055127e-02	1.043	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	7.799005e-02	1.108	0	0
Macroautophagy	R-HSA-1632852	7.801264e-02	1.108	0	0
DNA Repair	R-HSA-73894	7.543567e-02	1.122	0	0
Rab regulation of trafficking	R-HSA-9007101	7.685566e-02	1.114	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	8.091484e-02	1.092	0	0
G2/M Transition	R-HSA-69275	8.374090e-02	1.077	0	0
Mitotic G2-G2/M phases	R-HSA-453274	9.092331e-02	1.041	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.396737e-02	1.076	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.756867e-02	1.170	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	7.177036e-02	1.144	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	8.091484e-02	1.092	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.560033e-02	1.068	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.011676e-02	1.154	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.815052e-02	1.055	0	0
Signaling by PTK6	R-HSA-8848021	7.799005e-02	1.108	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.799005e-02	1.108	0	0
Co-inhibition by PD-1	R-HSA-389948	6.982909e-02	1.156	0	0
Glucose metabolism	R-HSA-70326	7.685566e-02	1.114	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.671922e-02	1.176	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.671922e-02	1.176	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.364961e-02	1.133	0	0
MAP kinase activation	R-HSA-450294	6.691018e-02	1.175	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.971596e-02	1.098	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.284561e-02	1.032	0	0
VLDLR internalisation and degradation	R-HSA-8866427	6.671922e-02	1.176	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.560033e-02	1.068	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.911106e-02	1.160	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	9.551582e-02	1.020	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	9.551582e-02	1.020	0	0
Vesicle-mediated transport	R-HSA-5653656	9.665812e-02	1.015	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.706973e-02	1.013	0	0
Mitophagy	R-HSA-5205647	9.706973e-02	1.013	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.933875e-02	1.003	0	0
Centrosome maturation	R-HSA-380287	9.945119e-02	1.002	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.990725e-02	1.000	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	1.024159e-01	0.990	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.024159e-01	0.990	0	0
Regulation of RAS by GAPs	R-HSA-5658442	1.028290e-01	0.988	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.060168e-01	0.975	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.060168e-01	0.975	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.060369e-01	0.975	0	0
Lipophagy	R-HSA-9613354	1.060369e-01	0.975	0	0
Gap junction degradation	R-HSA-190873	1.060369e-01	0.975	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.060369e-01	0.975	0	0
Regulation of Apoptosis	R-HSA-169911	1.064669e-01	0.973	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.064669e-01	0.973	0	0
Oncogene Induced Senescence	R-HSA-2559585	1.064669e-01	0.973	0	0
snRNP Assembly	R-HSA-191859	1.072737e-01	0.970	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.072737e-01	0.970	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.088488e-01	0.963	0	0
Hedgehog 'off' state	R-HSA-5610787	1.095299e-01	0.960	0	0
Host Interactions of HIV factors	R-HSA-162909	1.095563e-01	0.960	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.108057e-01	0.955	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.108057e-01	0.955	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.108057e-01	0.955	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.134496e-01	0.945	0	0
Kinesins	R-HSA-983189	1.149426e-01	0.940	0	0
Signaling by PDGFR in disease	R-HSA-9671555	1.150102e-01	0.939	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.150102e-01	0.939	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.150102e-01	0.939	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.170882e-01	0.931	0	0
DARPP-32 events	R-HSA-180024	1.170882e-01	0.931	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.170882e-01	0.931	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.170882e-01	0.931	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	1.192984e-01	0.923	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.192984e-01	0.923	0	0
Orc1 removal from chromatin	R-HSA-68949	1.192984e-01	0.923	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.207880e-01	0.918	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.222947e-01	0.913	0	0
Developmental Biology	R-HSA-1266738	1.228772e-01	0.911	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.228990e-01	0.910	0	0
Regulation of BACH1 activity	R-HSA-9708530	1.228990e-01	0.910	0	0
G1 Phase	R-HSA-69236	1.233166e-01	0.909	0	0
Cyclin D associated events in G1	R-HSA-69231	1.233166e-01	0.909	0	0
Netrin-1 signaling	R-HSA-373752	1.233166e-01	0.909	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.253210e-01	0.902	0	0
Interleukin-17 signaling	R-HSA-448424	1.253210e-01	0.902	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.261953e-01	0.899	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	1.261953e-01	0.899	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.261953e-01	0.899	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.266577e-01	0.897	0	0
Interleukin-12 family signaling	R-HSA-447115	1.276646e-01	0.894	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	1.280400e-01	0.893	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.280400e-01	0.893	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.283030e-01	0.892	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.283030e-01	0.892	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.283030e-01	0.892	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.283030e-01	0.892	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.283030e-01	0.892	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.287121e-01	0.890	0	0
Activation of BH3-only proteins	R-HSA-114452	1.287121e-01	0.890	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.289056e-01	0.890	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.289056e-01	0.890	0	0
Developmental Cell Lineages	R-HSA-9734767	1.299109e-01	0.886	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.311730e-01	0.882	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.342784e-01	0.872	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.342784e-01	0.872	0	0
Signaling by FGFR2	R-HSA-5654738	1.342784e-01	0.872	0	0
Opioid Signalling	R-HSA-111885	1.343390e-01	0.872	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.347571e-01	0.870	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.374273e-01	0.862	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.393340e-01	0.856	0	0
Disorders of Developmental Biology	R-HSA-9675151	1.393340e-01	0.856	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.393340e-01	0.856	0	0
HIV Infection	R-HSA-162906	1.396357e-01	0.855	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.400156e-01	0.854	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.408678e-01	0.851	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	1.408678e-01	0.851	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.417087e-01	0.849	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	1.421079e-01	0.847	0	0
IRS activation	R-HSA-74713	1.421079e-01	0.847	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.421079e-01	0.847	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.421079e-01	0.847	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.430072e-01	0.845	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.430072e-01	0.845	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.430072e-01	0.845	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.430072e-01	0.845	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.442173e-01	0.841	0	0
Signaling by NOTCH3	R-HSA-9012852	1.465047e-01	0.834	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	1.475941e-01	0.831	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.485611e-01	0.828	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.534016e-01	0.814	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.535317e-01	0.814	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	1.548577e-01	0.810	0	0
Ion homeostasis	R-HSA-5578775	1.562118e-01	0.806	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.562118e-01	0.806	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	1.565888e-01	0.805	0	0
Signaling by FGFR in disease	R-HSA-1226099	1.581816e-01	0.801	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.719421e-01	0.765	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.719421e-01	0.765	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.719421e-01	0.765	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.719421e-01	0.765	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.719421e-01	0.765	0	0
NFG and proNGF binds to p75NTR	R-HSA-205017	2.464931e-01	0.608	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.464931e-01	0.608	0	0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	R-HSA-5619045	2.464931e-01	0.608	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.464931e-01	0.608	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	2.464931e-01	0.608	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.464931e-01	0.608	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	2.464931e-01	0.608	0	0
Defective SLC34A2 causes PALM	R-HSA-5687583	2.464931e-01	0.608	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.464931e-01	0.608	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.464931e-01	0.608	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	2.464931e-01	0.608	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.749827e-01	0.757	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.749827e-01	0.757	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	1.749827e-01	0.757	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.143362e-01	0.503	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.143362e-01	0.503	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	3.143362e-01	0.503	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.143362e-01	0.503	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.143362e-01	0.503	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.143362e-01	0.503	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.088937e-01	0.680	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.088937e-01	0.680	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.088937e-01	0.680	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.700612e-01	0.769	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.700612e-01	0.769	0	0
SOS-mediated signalling	R-HSA-112412	2.433883e-01	0.614	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.433883e-01	0.614	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.934258e-01	0.713	0	0
MET receptor recycling	R-HSA-8875656	2.780869e-01	0.556	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.780869e-01	0.556	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.780869e-01	0.556	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.175218e-01	0.662	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.745870e-01	0.758	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.421897e-01	0.616	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.421897e-01	0.616	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.421897e-01	0.616	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	3.126736e-01	0.505	0	0
WNT mediated activation of DVL	R-HSA-201688	3.126736e-01	0.505	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.126736e-01	0.505	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.926457e-01	0.534	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.926457e-01	0.534	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.926457e-01	0.534	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.205264e-01	0.657	0	0
Formation of the Early Elongation Complex	R-HSA-113418	2.205264e-01	0.657	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.943069e-01	0.712	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.181601e-01	0.497	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.549290e-01	0.594	0	0
Dual incision in TC-NER	R-HSA-6782135	1.765281e-01	0.753	0	0
Degradation of AXIN	R-HSA-4641257	2.386287e-01	0.622	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.103382e-01	0.677	0	0
Deadenylation of mRNA	R-HSA-429947	3.146878e-01	0.502	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.226104e-01	0.652	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.226104e-01	0.652	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.514350e-01	0.600	0	0
Eukaryotic Translation Elongation	R-HSA-156842	1.733492e-01	0.761	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.479012e-01	0.606	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.694132e-01	0.771	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.608826e-01	0.584	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	2.620806e-01	0.582	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.929441e-01	0.533	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.056048e-01	0.515	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.485112e-01	0.605	0	0
HCMV Early Events	R-HSA-9609690	1.713969e-01	0.766	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.890777e-01	0.539	0	0
Eukaryotic Translation Initiation	R-HSA-72613	2.516047e-01	0.599	0	0
Cap-dependent Translation Initiation	R-HSA-72737	2.516047e-01	0.599	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.787612e-01	0.748	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.787612e-01	0.748	0	0
Extension of Telomeres	R-HSA-180786	3.009390e-01	0.522	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.375024e-01	0.624	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.787612e-01	0.748	0	0
p75NTR regulates axonogenesis	R-HSA-193697	3.126736e-01	0.505	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.375024e-01	0.624	0	0
Integration of provirus	R-HSA-162592	1.700612e-01	0.769	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.238322e-01	0.650	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	2.375024e-01	0.624	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	2.780869e-01	0.556	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.672783e-01	0.573	0	0
Mismatch Repair	R-HSA-5358508	1.745870e-01	0.758	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.780869e-01	0.556	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.126736e-01	0.505	0	0
Co-inhibition by CTLA4	R-HSA-389513	2.124956e-01	0.673	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.722499e-01	0.764	0	0
PKA activation	R-HSA-163615	1.745870e-01	0.758	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	2.386287e-01	0.622	0	0
Trafficking of AMPA receptors	R-HSA-399719	2.725989e-01	0.564	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.167570e-01	0.664	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.877012e-01	0.727	0	0
Integrin signaling	R-HSA-354192	1.666782e-01	0.778	0	0
Synthesis of DNA	R-HSA-69239	1.620498e-01	0.790	0	0
Degradation of CDH1	R-HSA-9766229	1.752268e-01	0.756	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	1.983389e-01	0.703	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.285104e-01	0.641	0	0
Activation and oligomerization of BAK protein	R-HSA-111452	1.719421e-01	0.765	0	0
Calcineurin activates NFAT	R-HSA-2025928	3.126736e-01	0.505	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.602408e-01	0.795	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	3.017137e-01	0.520	0	0
Peroxisomal protein import	R-HSA-9033241	3.009390e-01	0.522	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.177040e-01	0.662	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.320429e-01	0.634	0	0
Frs2-mediated activation	R-HSA-170968	2.175218e-01	0.662	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.846350e-01	0.734	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	2.780869e-01	0.556	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.877012e-01	0.727	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.943069e-01	0.712	0	0
Stabilization of p53	R-HSA-69541	2.697141e-01	0.569	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.071089e-01	0.684	0	0
Signaling by Hedgehog	R-HSA-5358351	2.993918e-01	0.524	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.720014e-01	0.764	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	2.697141e-01	0.569	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.288653e-01	0.640	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.038921e-01	0.691	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.672201e-01	0.573	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.846350e-01	0.734	0	0
Hedgehog 'on' state	R-HSA-5632684	2.177040e-01	0.662	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.725989e-01	0.564	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	2.672201e-01	0.573	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	2.214441e-01	0.655	0	0
Muscle contraction	R-HSA-397014	1.596439e-01	0.797	0	0
Prolonged ERK activation events	R-HSA-169893	2.926457e-01	0.534	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.666782e-01	0.778	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.779793e-01	0.556	0	0
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.719421e-01	0.765	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.464931e-01	0.608	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.464931e-01	0.608	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.749827e-01	0.757	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	1.749827e-01	0.757	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.143362e-01	0.503	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	3.143362e-01	0.503	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.175218e-01	0.662	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	1.932494e-01	0.714	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.943069e-01	0.712	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.181601e-01	0.497	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.937135e-01	0.532	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.375024e-01	0.624	0	0
Smooth Muscle Contraction	R-HSA-445355	2.226104e-01	0.652	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	2.090904e-01	0.680	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.351375e-01	0.629	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	2.259559e-01	0.646	0	0
HCMV Late Events	R-HSA-9610379	1.608044e-01	0.794	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.666782e-01	0.778	0	0
Generic Transcription Pathway	R-HSA-212436	2.396205e-01	0.620	1	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.597860e-01	0.585	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.856166e-01	0.544	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.601488e-01	0.795	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.181601e-01	0.497	0	0
Regulation of necroptotic cell death	R-HSA-5675482	3.086314e-01	0.511	0	0
Co-stimulation by CD28	R-HSA-389356	1.641459e-01	0.785	0	0
Nef and signal transduction	R-HSA-164944	2.088937e-01	0.680	0	0
CHL1 interactions	R-HSA-447041	2.433883e-01	0.614	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.934258e-01	0.713	0	0
Disorders of Nervous System Development	R-HSA-9697154	1.934258e-01	0.713	0	0
Pervasive developmental disorders	R-HSA-9005895	1.934258e-01	0.713	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.126736e-01	0.505	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.672783e-01	0.573	0	0
Regulation of KIT signaling	R-HSA-1433559	2.421897e-01	0.616	0	0
Signaling by FGFR4	R-HSA-5654743	2.104486e-01	0.677	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.749827e-01	0.757	0	0
DSCAM interactions	R-HSA-376172	3.143362e-01	0.503	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.181601e-01	0.497	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.086314e-01	0.511	0	0
Signaling by FGFR3	R-HSA-5654741	2.375024e-01	0.624	0	0
Inositol phosphate metabolism	R-HSA-1483249	2.863981e-01	0.543	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.175218e-01	0.662	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.126736e-01	0.505	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.672783e-01	0.573	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.322446e-01	0.634	0	0
PI Metabolism	R-HSA-1483255	2.741657e-01	0.562	0	0
Syndecan interactions	R-HSA-3000170	2.937135e-01	0.532	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.722499e-01	0.764	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.697141e-01	0.569	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.086314e-01	0.511	0	0
Insulin processing	R-HSA-264876	2.038921e-01	0.691	0	0
Plasma lipoprotein assembly	R-HSA-8963898	3.146878e-01	0.502	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.126736e-01	0.505	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.672783e-01	0.573	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.322446e-01	0.634	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.126736e-01	0.505	0	0
Stimuli-sensing channels	R-HSA-2672351	2.485112e-01	0.605	1	1
HDL assembly	R-HSA-8963896	2.421897e-01	0.616	0	0
Translation of Structural Proteins	R-HSA-9683701	3.179714e-01	0.498	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	3.183886e-01	0.497	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	3.241557e-01	0.489	0	0
Striated Muscle Contraction	R-HSA-390522	3.268985e-01	0.486	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	3.268985e-01	0.486	0	0
Vpu mediated degradation of CD4	R-HSA-180534	3.268985e-01	0.486	0	0
HCMV Infection	R-HSA-9609646	3.326562e-01	0.478	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.343564e-01	0.476	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.347112e-01	0.475	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.354217e-01	0.474	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.354217e-01	0.474	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.354217e-01	0.474	0	0
Signaling by FGFR	R-HSA-190236	3.354217e-01	0.474	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	3.356741e-01	0.474	0	0
HDMs demethylate histones	R-HSA-3214842	3.357833e-01	0.474	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.357833e-01	0.474	0	0
Interferon Signaling	R-HSA-913531	3.394105e-01	0.469	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	3.416818e-01	0.466	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.422494e-01	0.466	0	0
tRNA processing in the nucleus	R-HSA-6784531	3.422494e-01	0.466	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	3.422494e-01	0.466	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.437002e-01	0.464	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.437002e-01	0.464	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.437002e-01	0.464	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.437002e-01	0.464	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.452710e-01	0.462	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	3.452710e-01	0.462	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.452710e-01	0.462	0	0
L1CAM interactions	R-HSA-373760	3.461769e-01	0.461	0	0
FOXO-mediated transcription	R-HSA-9614085	3.464782e-01	0.460	0	0
Binding and entry of HIV virion	R-HSA-173107	3.468873e-01	0.460	0	0
2-LTR circle formation	R-HSA-164843	3.468873e-01	0.460	0	0
Regulation of CDH11 function	R-HSA-9762292	3.468873e-01	0.460	0	0
PI3K/AKT activation	R-HSA-198203	3.468873e-01	0.460	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	3.468873e-01	0.460	0	0
Signal attenuation	R-HSA-74749	3.468873e-01	0.460	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.468873e-01	0.460	0	0
Signaling by Leptin	R-HSA-2586552	3.468873e-01	0.460	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.508361e-01	0.455	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.508361e-01	0.455	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	3.569321e-01	0.447	0	0
Suppression of phagosomal maturation	R-HSA-9637687	3.569321e-01	0.447	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.578678e-01	0.446	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.637044e-01	0.439	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.637044e-01	0.439	0	0
Platelet degranulation	R-HSA-114608	3.654318e-01	0.437	0	0
Interleukin-1 signaling	R-HSA-9020702	3.687734e-01	0.433	0	0
Ephrin signaling	R-HSA-3928664	3.691553e-01	0.433	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.691553e-01	0.433	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.691553e-01	0.433	0	0
PKA activation in glucagon signalling	R-HSA-164378	3.691553e-01	0.433	0	0
Platelet sensitization by LDL	R-HSA-432142	3.691553e-01	0.433	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.703718e-01	0.431	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.704340e-01	0.431	0	0
Signaling by ERBB4	R-HSA-1236394	3.704340e-01	0.431	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	3.760746e-01	0.425	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.760746e-01	0.425	0	0
Axonal growth stimulation	R-HSA-209563	3.760746e-01	0.425	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.760746e-01	0.425	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.760746e-01	0.425	0	0
MET activates PTPN11	R-HSA-8865999	3.760746e-01	0.425	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.760746e-01	0.425	0	0
Type II Na+/Pi cotransporters	R-HSA-427589	3.760746e-01	0.425	0	0
Histamine receptors	R-HSA-390650	3.760746e-01	0.425	0	0
SARS-CoV-2 Infection	R-HSA-9694516	3.763671e-01	0.424	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.769619e-01	0.424	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.769619e-01	0.424	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.780703e-01	0.422	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	3.780703e-01	0.422	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.805151e-01	0.420	0	0
Bicarbonate transporters	R-HSA-425381	3.805151e-01	0.420	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.805151e-01	0.420	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.821560e-01	0.418	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.839519e-01	0.416	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	3.839519e-01	0.416	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.839519e-01	0.416	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.839519e-01	0.416	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.892861e-01	0.410	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.892861e-01	0.410	0	0
Maturation of nucleoprotein	R-HSA-9694631	3.944256e-01	0.404	0	0
STING mediated induction of host immune responses	R-HSA-1834941	3.944256e-01	0.404	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.950281e-01	0.403	0	0
Telomere Extension By Telomerase	R-HSA-171319	3.991378e-01	0.399	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.991378e-01	0.399	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	3.991378e-01	0.399	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.996736e-01	0.398	0	0
Signaling by FGFR1	R-HSA-5654736	3.996736e-01	0.398	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	4.005268e-01	0.397	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	4.074872e-01	0.390	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.080729e-01	0.389	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.080729e-01	0.389	0	0
Influenza Infection	R-HSA-168255	4.098393e-01	0.387	0	0
Translation of Structural Proteins	R-HSA-9694635	4.099815e-01	0.387	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.124512e-01	0.385	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.133852e-01	0.384	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.133852e-01	0.384	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.133852e-01	0.384	0	0
Cardiac conduction	R-HSA-5576891	4.153560e-01	0.382	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.168351e-01	0.380	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	4.168351e-01	0.380	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.170739e-01	0.380	0	0
Recycling pathway of L1	R-HSA-437239	4.170739e-01	0.380	0	0
MET promotes cell motility	R-HSA-8875878	4.189515e-01	0.378	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	4.189515e-01	0.378	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.194212e-01	0.377	0	0
Pyruvate metabolism	R-HSA-70268	4.199522e-01	0.377	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.200785e-01	0.377	0	0
mRNA Capping	R-HSA-72086	4.200785e-01	0.377	0	0
PCP/CE pathway	R-HSA-4086400	4.231800e-01	0.373	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	4.253968e-01	0.371	0	0
HCN channels	R-HSA-1296061	4.322573e-01	0.364	0	0
NADE modulates death signalling	R-HSA-205025	4.322573e-01	0.364	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.322573e-01	0.364	0	0
ATP sensitive Potassium channels	R-HSA-1296025	4.322573e-01	0.364	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.322573e-01	0.364	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.322573e-01	0.364	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.322573e-01	0.364	0	0
Signaling by MAP2K mutants	R-HSA-9652169	4.322573e-01	0.364	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.322573e-01	0.364	0	0
Regulation of gap junction activity	R-HSA-191650	4.322573e-01	0.364	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.322573e-01	0.364	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.322573e-01	0.364	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.322573e-01	0.364	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.322938e-01	0.364	0	0
Peptide chain elongation	R-HSA-156902	4.324108e-01	0.364	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.325618e-01	0.364	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.372197e-01	0.359	0	0
RAS processing	R-HSA-9648002	4.372197e-01	0.359	0	0
Plasma lipoprotein clearance	R-HSA-8964043	4.372197e-01	0.359	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.405041e-01	0.356	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.408409e-01	0.356	0	0
Activation of the pre-replicative complex	R-HSA-68962	4.408409e-01	0.356	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.408409e-01	0.356	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	4.408409e-01	0.356	0	0
Lagging Strand Synthesis	R-HSA-69186	4.440629e-01	0.353	0	0
Basigin interactions	R-HSA-210991	4.440629e-01	0.353	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.453615e-01	0.351	0	0
Leading Strand Synthesis	R-HSA-69109	4.453615e-01	0.351	0	0
Polymerase switching	R-HSA-69091	4.453615e-01	0.351	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.453615e-01	0.351	0	0
PKR-mediated signaling	R-HSA-9833482	4.495134e-01	0.347	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	4.499748e-01	0.347	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.553545e-01	0.342	0	0
HIV Transcription Elongation	R-HSA-167169	4.553545e-01	0.342	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.553545e-01	0.342	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.589737e-01	0.338	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.626205e-01	0.335	0	0
SARS-CoV-1 Infection	R-HSA-9678108	4.659866e-01	0.332	0	0
Regulation of mitotic cell cycle	R-HSA-453276	4.684958e-01	0.329	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.684958e-01	0.329	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.702101e-01	0.328	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.733237e-01	0.325	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.750316e-01	0.323	0	0
Formation of axial mesoderm	R-HSA-9796292	4.763386e-01	0.322	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.763386e-01	0.322	0	0
Maturation of nucleoprotein	R-HSA-9683610	4.763386e-01	0.322	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.763386e-01	0.322	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.763386e-01	0.322	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.802000e-01	0.319	0	0
IRE1alpha activates chaperones	R-HSA-381070	4.819429e-01	0.317	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	4.833839e-01	0.316	0	0
PTK6 Down-Regulation	R-HSA-8849472	4.833839e-01	0.316	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.833839e-01	0.316	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.833839e-01	0.316	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.833839e-01	0.316	0	0
Reelin signalling pathway	R-HSA-8866376	4.833839e-01	0.316	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.833839e-01	0.316	0	0
Inositol transporters	R-HSA-429593	4.833839e-01	0.316	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.833839e-01	0.316	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.833839e-01	0.316	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.854895e-01	0.314	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	4.864747e-01	0.313	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	4.875246e-01	0.312	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.910970e-01	0.309	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	4.910970e-01	0.309	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.920140e-01	0.308	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.938827e-01	0.306	0	0
Ion channel transport	R-HSA-983712	4.961284e-01	0.304	1	0
Uptake and actions of bacterial toxins	R-HSA-5339562	4.984645e-01	0.302	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.984645e-01	0.302	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.994250e-01	0.302	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.016023e-01	0.300	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.016023e-01	0.300	0	0
Activation of ATR in response to replication stress	R-HSA-176187	5.016023e-01	0.300	0	0
CRMPs in Sema3A signaling	R-HSA-399956	5.062372e-01	0.296	0	0
Signal regulatory protein family interactions	R-HSA-391160	5.062372e-01	0.296	0	0
Physiological factors	R-HSA-5578768	5.062372e-01	0.296	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.086465e-01	0.294	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.146949e-01	0.288	0	0
Signaling by Interleukins	R-HSA-449147	5.148128e-01	0.288	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.152110e-01	0.288	0	0
Growth hormone receptor signaling	R-HSA-982772	5.152110e-01	0.288	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.184636e-01	0.285	0	0
Ion transport by P-type ATPases	R-HSA-936837	5.190973e-01	0.285	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.212167e-01	0.283	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	5.259468e-01	0.279	0	0
Neutrophil degranulation	R-HSA-6798695	5.261300e-01	0.279	0	0
Plus-strand DNA synthesis	R-HSA-164525	5.299092e-01	0.276	0	0
PDE3B signalling	R-HSA-165160	5.299092e-01	0.276	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.299092e-01	0.276	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.299092e-01	0.276	0	0
PKB-mediated events	R-HSA-109703	5.299092e-01	0.276	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.299092e-01	0.276	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.299092e-01	0.276	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.299092e-01	0.276	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.299092e-01	0.276	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.299092e-01	0.276	0	0
Cam-PDE 1 activation	R-HSA-111957	5.299092e-01	0.276	0	0
Ceramide signalling	R-HSA-193681	5.299092e-01	0.276	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.299092e-01	0.276	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.299092e-01	0.276	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.299092e-01	0.276	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.304627e-01	0.275	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.304627e-01	0.275	0	0
RSV-host interactions	R-HSA-9833110	5.336154e-01	0.273	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.350002e-01	0.272	0	0
Processive synthesis on the lagging strand	R-HSA-69183	5.350002e-01	0.272	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.350002e-01	0.272	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.350002e-01	0.272	0	0
UCH proteinases	R-HSA-5689603	5.366851e-01	0.270	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.378278e-01	0.269	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	5.378278e-01	0.269	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.378278e-01	0.269	0	0
Cellular response to chemical stress	R-HSA-9711123	5.391482e-01	0.268	0	0
eNOS activation	R-HSA-203615	5.404561e-01	0.267	0	0
Calnexin/calreticulin cycle	R-HSA-901042	5.404561e-01	0.267	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.598281e-01	0.252	0	0
TGFBR3 expression	R-HSA-9839394	5.598281e-01	0.252	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	5.598281e-01	0.252	0	0
G1/S Transition	R-HSA-69206	5.599481e-01	0.252	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.625899e-01	0.250	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.625899e-01	0.250	0	0
Killing mechanisms	R-HSA-9664420	5.625899e-01	0.250	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.625899e-01	0.250	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.625899e-01	0.250	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	5.625899e-01	0.250	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	5.625899e-01	0.250	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.625899e-01	0.250	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.722471e-01	0.242	0	0
STAT5 Activation	R-HSA-9645135	5.722471e-01	0.242	0	0
Autointegration results in viral DNA circles	R-HSA-177539	5.722471e-01	0.242	0	0
Uncoating of the HIV Virion	R-HSA-162585	5.722471e-01	0.242	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.722471e-01	0.242	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.722471e-01	0.242	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	5.722471e-01	0.242	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	5.722471e-01	0.242	0	0
Neurofascin interactions	R-HSA-447043	5.722471e-01	0.242	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.722471e-01	0.242	0	0
VLDL assembly	R-HSA-8866423	5.722471e-01	0.242	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	5.777038e-01	0.238	0	0
Mitochondrial biogenesis	R-HSA-1592230	5.792088e-01	0.237	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.811826e-01	0.236	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	5.813029e-01	0.236	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	5.819612e-01	0.235	0	0
Adaptive Immune System	R-HSA-1280218	5.822146e-01	0.235	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.880489e-01	0.231	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.889842e-01	0.230	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	5.889842e-01	0.230	0	0
Cilium Assembly	R-HSA-5617833	5.951693e-01	0.225	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	6.002706e-01	0.222	0	0
Ribosome-associated quality control	R-HSA-9948299	6.004735e-01	0.222	0	0
Signaling by NTRKs	R-HSA-166520	6.009186e-01	0.221	1	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.018684e-01	0.220	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.018684e-01	0.220	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.018684e-01	0.220	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.018684e-01	0.220	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.046948e-01	0.218	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	6.067858e-01	0.217	0	0
NGF-stimulated transcription	R-HSA-9031628	6.079710e-01	0.216	1	1
Metal ion SLC transporters	R-HSA-425410	6.079710e-01	0.216	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	6.099115e-01	0.215	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.107741e-01	0.214	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.107741e-01	0.214	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.107741e-01	0.214	0	0
Netrin mediated repulsion signals	R-HSA-418886	6.107741e-01	0.214	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.107741e-01	0.214	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.107741e-01	0.214	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.107741e-01	0.214	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.107741e-01	0.214	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.107741e-01	0.214	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.107741e-01	0.214	0	0
Recycling of eIF2:GDP	R-HSA-72731	6.107741e-01	0.214	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.107741e-01	0.214	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.107741e-01	0.214	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.107741e-01	0.214	0	0
LDL remodeling	R-HSA-8964041	6.107741e-01	0.214	0	0
VLDL clearance	R-HSA-8964046	6.107741e-01	0.214	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	6.107741e-01	0.214	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.107741e-01	0.214	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.131683e-01	0.212	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.131683e-01	0.212	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	6.141746e-01	0.212	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.141746e-01	0.212	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.141746e-01	0.212	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.141746e-01	0.212	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.141746e-01	0.212	0	0
HIV elongation arrest and recovery	R-HSA-167287	6.218684e-01	0.206	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	6.218684e-01	0.206	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.218684e-01	0.206	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.236395e-01	0.205	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.236395e-01	0.205	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.257718e-01	0.204	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.286839e-01	0.202	1	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.327055e-01	0.199	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.366502e-01	0.196	0	0
Interleukin-1 family signaling	R-HSA-446652	6.368284e-01	0.196	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.381639e-01	0.195	0	0
PI3K Cascade	R-HSA-109704	6.383866e-01	0.195	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	6.383866e-01	0.195	0	0
Signaling by Erythropoietin	R-HSA-9006335	6.411707e-01	0.193	0	0
Platelet calcium homeostasis	R-HSA-418360	6.411707e-01	0.193	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	6.411707e-01	0.193	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.411707e-01	0.193	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.435045e-01	0.191	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	6.458332e-01	0.190	0	0
Minus-strand DNA synthesis	R-HSA-164516	6.458332e-01	0.190	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.458332e-01	0.190	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.458332e-01	0.190	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.458332e-01	0.190	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.458332e-01	0.190	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	6.458332e-01	0.190	0	0
Interleukin-23 signaling	R-HSA-9020933	6.458332e-01	0.190	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.467253e-01	0.189	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.467253e-01	0.189	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	6.467253e-01	0.189	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.530339e-01	0.185	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.597683e-01	0.181	0	0
Interleukin-37 signaling	R-HSA-9008059	6.597683e-01	0.181	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.609641e-01	0.180	0	0
Germ layer formation at gastrulation	R-HSA-9754189	6.609641e-01	0.180	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.609641e-01	0.180	0	0
The NLRP3 inflammasome	R-HSA-844456	6.609641e-01	0.180	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.627625e-01	0.179	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.670770e-01	0.176	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.672973e-01	0.176	0	0
IGF1R signaling cascade	R-HSA-2428924	6.724552e-01	0.172	0	0
MAPK1 (ERK2) activation	R-HSA-112411	6.777362e-01	0.169	0	0
ALK mutants bind TKIs	R-HSA-9700645	6.777362e-01	0.169	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.777362e-01	0.169	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	6.777362e-01	0.169	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.777362e-01	0.169	0	0
ARMS-mediated activation	R-HSA-170984	6.777362e-01	0.169	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.777362e-01	0.169	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.777362e-01	0.169	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	6.777362e-01	0.169	0	0
Interleukin-1 processing	R-HSA-448706	6.777362e-01	0.169	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	6.777362e-01	0.169	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.811711e-01	0.167	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.825946e-01	0.166	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.825946e-01	0.166	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.825946e-01	0.166	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.825946e-01	0.166	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.825946e-01	0.166	0	0
Signaling by NODAL	R-HSA-1181150	6.825946e-01	0.166	0	0
Protein hydroxylation	R-HSA-9629569	6.825946e-01	0.166	0	0
Formation of definitive endoderm	R-HSA-9823730	6.825946e-01	0.166	0	0
Integration of energy metabolism	R-HSA-163685	6.838146e-01	0.165	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.850750e-01	0.164	0	0
Toll-like Receptor Cascades	R-HSA-168898	6.897276e-01	0.161	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.946510e-01	0.158	0	0
G0 and Early G1	R-HSA-1538133	6.948418e-01	0.158	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.955790e-01	0.158	1	0
SARS-CoV Infections	R-HSA-9679506	6.964432e-01	0.157	0	0
Regulation of insulin secretion	R-HSA-422356	6.988448e-01	0.156	0	0
ABC transporter disorders	R-HSA-5619084	7.008319e-01	0.154	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.030813e-01	0.153	0	0
ERK/MAPK targets	R-HSA-198753	7.030813e-01	0.153	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.067672e-01	0.151	0	0
Folding of actin by CCT/TriC	R-HSA-390450	7.067672e-01	0.151	0	0
Regulation of the apoptosome activity	R-HSA-9627069	7.067672e-01	0.151	0	0
Formation of apoptosome	R-HSA-111458	7.067672e-01	0.151	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.067672e-01	0.151	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	7.067672e-01	0.151	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.067672e-01	0.151	0	0
CASP4 inflammasome assembly	R-HSA-9948001	7.067672e-01	0.151	0	0
Tandem pore domain potassium channels	R-HSA-1296346	7.067672e-01	0.151	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	7.067672e-01	0.151	0	0
Signaling by SCF-KIT	R-HSA-1433557	7.078454e-01	0.150	0	0
G-protein beta:gamma signalling	R-HSA-397795	7.113231e-01	0.148	0	0
TCR signaling	R-HSA-202403	7.129542e-01	0.147	0	0
Downstream TCR signaling	R-HSA-202424	7.150326e-01	0.146	0	0
ABC-family proteins mediated transport	R-HSA-382556	7.184843e-01	0.144	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.204197e-01	0.142	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.209886e-01	0.142	0	0
Regulated Necrosis	R-HSA-5218859	7.209886e-01	0.142	0	0
Attachment and Entry	R-HSA-9694614	7.224545e-01	0.141	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.251293e-01	0.140	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	7.271094e-01	0.138	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.271094e-01	0.138	0	0
IRS-mediated signalling	R-HSA-112399	7.327069e-01	0.135	0	0
PECAM1 interactions	R-HSA-210990	7.331845e-01	0.135	0	0
LGI-ADAM interactions	R-HSA-5682910	7.331845e-01	0.135	0	0
vRNP Assembly	R-HSA-192905	7.331845e-01	0.135	0	0
Chylomicron assembly	R-HSA-8963888	7.331845e-01	0.135	0	0
Synthesis of PI	R-HSA-1483226	7.331845e-01	0.135	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.331845e-01	0.135	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.331845e-01	0.135	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.331845e-01	0.135	0	0
Suppression of apoptosis	R-HSA-9635465	7.331845e-01	0.135	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.331845e-01	0.135	0	0
Interleukin-2 signaling	R-HSA-9020558	7.331845e-01	0.135	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.331845e-01	0.135	0	0
Fanconi Anemia Pathway	R-HSA-6783310	7.353670e-01	0.133	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.353670e-01	0.133	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.407486e-01	0.130	0	0
Diseases of DNA repair	R-HSA-9675135	7.483746e-01	0.126	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.483746e-01	0.126	0	0
Signaling by TGFBR3	R-HSA-9839373	7.483746e-01	0.126	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.539515e-01	0.123	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	7.539552e-01	0.123	0	0
Signalling to ERKs	R-HSA-187687	7.566388e-01	0.121	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.572233e-01	0.121	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.572233e-01	0.121	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.572233e-01	0.121	0	0
ERKs are inactivated	R-HSA-202670	7.572233e-01	0.121	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.572233e-01	0.121	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.572233e-01	0.121	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.572233e-01	0.121	0	0
Sodium/Calcium exchangers	R-HSA-425561	7.572233e-01	0.121	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.580008e-01	0.120	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.580008e-01	0.120	0	0
Interleukin receptor SHC signaling	R-HSA-912526	7.580008e-01	0.120	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	7.580008e-01	0.120	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.580008e-01	0.120	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.580008e-01	0.120	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.608867e-01	0.119	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.619262e-01	0.118	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.642842e-01	0.117	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.671946e-01	0.115	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.704078e-01	0.113	0	0
RNA Polymerase III Transcription	R-HSA-74158	7.704078e-01	0.113	0	0
RUNX2 regulates bone development	R-HSA-8941326	7.704078e-01	0.113	0	0
Triglyceride catabolism	R-HSA-163560	7.704078e-01	0.113	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	7.729100e-01	0.112	0	0
Gluconeogenesis	R-HSA-70263	7.729100e-01	0.112	0	0
Cellular response to starvation	R-HSA-9711097	7.731212e-01	0.112	0	0
Ca2+ pathway	R-HSA-4086398	7.742923e-01	0.111	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	7.790976e-01	0.108	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	7.790976e-01	0.108	0	0
Scavenging by Class F Receptors	R-HSA-3000484	7.790976e-01	0.108	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	7.790976e-01	0.108	0	0
Repression of WNT target genes	R-HSA-4641265	7.790976e-01	0.108	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	7.790976e-01	0.108	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.790976e-01	0.108	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.790976e-01	0.108	0	0
Signaling by LTK	R-HSA-9842663	7.790976e-01	0.108	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.790976e-01	0.108	0	0
Regulation of IFNG signaling	R-HSA-877312	7.790976e-01	0.108	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.790976e-01	0.108	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	7.790976e-01	0.108	0	0
Interleukin-15 signaling	R-HSA-8983432	7.790976e-01	0.108	0	0
OAS antiviral response	R-HSA-8983711	7.790976e-01	0.108	0	0
Interferon gamma signaling	R-HSA-877300	7.798637e-01	0.108	0	0
Eukaryotic Translation Termination	R-HSA-72764	7.805820e-01	0.108	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.820092e-01	0.107	0	0
Gap junction trafficking and regulation	R-HSA-157858	7.844522e-01	0.105	0	0
Signaling by TGFB family members	R-HSA-9006936	7.864656e-01	0.104	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.884041e-01	0.103	0	0
COPI-mediated anterograde transport	R-HSA-6807878	7.889722e-01	0.103	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.895375e-01	0.103	0	0
Tight junction interactions	R-HSA-420029	7.895375e-01	0.103	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.895375e-01	0.103	0	0
Laminin interactions	R-HSA-3000157	7.895375e-01	0.103	0	0
Hyaluronan degradation	R-HSA-2160916	7.895375e-01	0.103	0	0
Interleukin-7 signaling	R-HSA-1266695	7.895375e-01	0.103	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.960316e-01	0.099	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.981934e-01	0.098	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.990022e-01	0.097	0	0
Microbial factors inhibit CASP4 activity	R-HSA-9956593	7.990022e-01	0.097	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	7.990022e-01	0.097	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.990022e-01	0.097	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	7.990022e-01	0.097	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.990022e-01	0.097	0	0
Interleukin-6 signaling	R-HSA-1059683	7.990022e-01	0.097	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.039040e-01	0.095	0	0
The phototransduction cascade	R-HSA-2514856	8.061294e-01	0.094	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.066708e-01	0.093	0	0
Insulin receptor signalling cascade	R-HSA-74751	8.077744e-01	0.093	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.079210e-01	0.093	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.101230e-01	0.091	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.106605e-01	0.091	0	0
ER-Phagosome pathway	R-HSA-1236974	8.154099e-01	0.089	0	0
Cellular response to hypoxia	R-HSA-1234174	8.169900e-01	0.088	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.170562e-01	0.088	0	0
Removal of the Flap Intermediate	R-HSA-69166	8.171143e-01	0.088	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.171143e-01	0.088	0	0
cGMP effects	R-HSA-418457	8.171143e-01	0.088	0	0
Synthesis of IPs in the nucleus	R-HSA-1855191	8.171143e-01	0.088	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.171143e-01	0.088	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	8.171143e-01	0.088	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.171143e-01	0.088	0	0
Non-canonical inflammasome activation	R-HSA-9686114	8.171143e-01	0.088	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	8.173916e-01	0.088	0	0
Diseases of Immune System	R-HSA-5260271	8.192201e-01	0.087	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.192201e-01	0.087	0	0
Interleukin-2 family signaling	R-HSA-451927	8.192201e-01	0.087	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.259981e-01	0.083	0	0
Selenocysteine synthesis	R-HSA-2408557	8.273667e-01	0.082	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.277107e-01	0.082	0	0
Sensory processing of sound	R-HSA-9659379	8.277107e-01	0.082	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	8.299482e-01	0.081	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.300419e-01	0.081	0	0
Insulin receptor recycling	R-HSA-77387	8.300419e-01	0.081	0	0
Inflammasomes	R-HSA-622312	8.300419e-01	0.081	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.335954e-01	0.079	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.335954e-01	0.079	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.335954e-01	0.079	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.335954e-01	0.079	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.335954e-01	0.079	0	0
Other semaphorin interactions	R-HSA-416700	8.335954e-01	0.079	0	0
Formation of the anterior neural plate	R-HSA-9823739	8.335954e-01	0.079	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.401250e-01	0.076	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.401250e-01	0.076	0	0
Viral mRNA Translation	R-HSA-192823	8.411147e-01	0.075	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.418963e-01	0.075	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.418963e-01	0.075	0	0
Regulation of gene expression in beta cells	R-HSA-210745	8.418963e-01	0.075	0	0
Transcription of the HIV genome	R-HSA-167172	8.425181e-01	0.074	0	0
Signaling by Insulin receptor	R-HSA-74752	8.449828e-01	0.073	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.485921e-01	0.071	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.485921e-01	0.071	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.485921e-01	0.071	0	0
Attachment and Entry	R-HSA-9678110	8.485921e-01	0.071	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.526086e-01	0.069	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.529954e-01	0.069	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.529954e-01	0.069	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	8.622380e-01	0.064	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	8.622380e-01	0.064	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.622380e-01	0.064	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.622380e-01	0.064	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	8.622380e-01	0.064	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	8.622380e-01	0.064	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.622380e-01	0.064	0	0
Phase 2 - plateau phase	R-HSA-5576893	8.622380e-01	0.064	0	0
Fibronectin matrix formation	R-HSA-1566977	8.622380e-01	0.064	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	8.622380e-01	0.064	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.622380e-01	0.064	0	0
Downstream signal transduction	R-HSA-186763	8.633791e-01	0.064	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.633791e-01	0.064	0	0
Platelet homeostasis	R-HSA-418346	8.660001e-01	0.062	0	0
Potential therapeutics for SARS	R-HSA-9679191	8.665803e-01	0.062	0	0
Gap junction trafficking	R-HSA-190828	8.675490e-01	0.062	0	0
RMTs methylate histone arginines	R-HSA-3214858	8.675490e-01	0.062	0	0
Neddylation	R-HSA-8951664	8.678860e-01	0.062	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.730861e-01	0.059	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	8.746549e-01	0.058	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.746549e-01	0.058	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.746549e-01	0.058	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.746549e-01	0.058	0	0
Choline catabolism	R-HSA-6798163	8.746549e-01	0.058	0	0
Neuronal System	R-HSA-112316	8.747340e-01	0.058	0	0
Triglyceride metabolism	R-HSA-8979227	8.756821e-01	0.058	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.756821e-01	0.058	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.757223e-01	0.058	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.764624e-01	0.057	0	0
Antigen processing-Cross presentation	R-HSA-1236975	8.772011e-01	0.057	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	8.784947e-01	0.056	0	0
Protein localization	R-HSA-9609507	8.806481e-01	0.055	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.821539e-01	0.054	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.821539e-01	0.054	0	0
Cardiogenesis	R-HSA-9733709	8.821539e-01	0.054	0	0
Adipogenesis	R-HSA-9843745	8.852356e-01	0.053	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.859532e-01	0.053	0	0
GAB1 signalosome	R-HSA-180292	8.859532e-01	0.053	0	0
Polo-like kinase mediated events	R-HSA-156711	8.859532e-01	0.053	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.859532e-01	0.053	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	8.859532e-01	0.053	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.859532e-01	0.053	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.859532e-01	0.053	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.882394e-01	0.051	0	0
Resolution of D-Loop Structures	R-HSA-5693537	8.906190e-01	0.050	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.906190e-01	0.050	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.906190e-01	0.050	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.906190e-01	0.050	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.907910e-01	0.050	0	0
Hemostasis	R-HSA-109582	8.922993e-01	0.049	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.962338e-01	0.048	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.962338e-01	0.048	0	0
Specification of the neural plate border	R-HSA-9834899	8.962338e-01	0.048	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	8.962338e-01	0.048	0	0
GPER1 signaling	R-HSA-9634597	8.976168e-01	0.047	0	0
MHC class II antigen presentation	R-HSA-2132295	8.976681e-01	0.047	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.985163e-01	0.046	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.985163e-01	0.046	0	0
Hyaluronan metabolism	R-HSA-2142845	8.985163e-01	0.046	0	0
Viral Infection Pathways	R-HSA-9824446	9.006550e-01	0.045	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	9.055882e-01	0.043	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.055882e-01	0.043	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.055882e-01	0.043	0	0
Signal transduction by L1	R-HSA-445144	9.055882e-01	0.043	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	9.058793e-01	0.043	0	0
PERK regulates gene expression	R-HSA-381042	9.058793e-01	0.043	0	0
Integrin cell surface interactions	R-HSA-216083	9.072192e-01	0.042	0	0
rRNA processing	R-HSA-72312	9.073265e-01	0.042	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.076363e-01	0.042	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.085484e-01	0.042	0	0
Leishmania infection	R-HSA-9658195	9.085484e-01	0.042	0	0
Extracellular matrix organization	R-HSA-1474244	9.136201e-01	0.039	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.140998e-01	0.039	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.140998e-01	0.039	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	9.140998e-01	0.039	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.154744e-01	0.038	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.191295e-01	0.037	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.218445e-01	0.035	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.218445e-01	0.035	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.218445e-01	0.035	0	0
Serine metabolism	R-HSA-977347	9.218445e-01	0.035	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.218445e-01	0.035	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.218445e-01	0.035	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.218445e-01	0.035	0	0
Leishmania phagocytosis	R-HSA-9664417	9.247362e-01	0.034	0	0
Parasite infection	R-HSA-9664407	9.247362e-01	0.034	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.247362e-01	0.034	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.250766e-01	0.034	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.254425e-01	0.034	0	0
Collagen formation	R-HSA-1474290	9.260359e-01	0.033	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.288913e-01	0.032	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.288913e-01	0.032	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.288913e-01	0.032	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.288913e-01	0.032	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.288913e-01	0.032	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	9.288913e-01	0.032	0	0
Ethanol oxidation	R-HSA-71384	9.288913e-01	0.032	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.288913e-01	0.032	0	0
LDL clearance	R-HSA-8964038	9.288913e-01	0.032	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.288913e-01	0.032	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.298224e-01	0.032	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.306092e-01	0.031	0	0
Pentose phosphate pathway	R-HSA-71336	9.306092e-01	0.031	0	0
SLC transporter disorders	R-HSA-5619102	9.312561e-01	0.031	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.353032e-01	0.029	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.353032e-01	0.029	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.353032e-01	0.029	0	0
Carnitine shuttle	R-HSA-200425	9.353032e-01	0.029	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.357537e-01	0.029	0	0
Generation of second messenger molecules	R-HSA-202433	9.357537e-01	0.029	0	0
G alpha (z) signalling events	R-HSA-418597	9.357876e-01	0.029	0	0
Metabolism of cofactors	R-HSA-8978934	9.394015e-01	0.027	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.405351e-01	0.027	0	0
Maturation of spike protein	R-HSA-9694548	9.405351e-01	0.027	0	0
Complex III assembly	R-HSA-9865881	9.411373e-01	0.026	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.411373e-01	0.026	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.449769e-01	0.025	0	0
HIV Transcription Initiation	R-HSA-167161	9.449769e-01	0.025	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.449769e-01	0.025	0	0
Intra-Golgi traffic	R-HSA-6811438	9.449769e-01	0.025	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.464455e-01	0.024	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.464455e-01	0.024	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.464455e-01	0.024	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.473797e-01	0.023	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.477118e-01	0.023	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.477118e-01	0.023	0	0
Regulation of beta-cell development	R-HSA-186712	9.512049e-01	0.022	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.512754e-01	0.022	0	0
TRP channels	R-HSA-3295583	9.512754e-01	0.022	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.512754e-01	0.022	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.512754e-01	0.022	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.512754e-01	0.022	0	0
Iron uptake and transport	R-HSA-917937	9.528639e-01	0.021	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.529302e-01	0.021	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.545391e-01	0.020	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.556699e-01	0.020	0	0
Cristae formation	R-HSA-8949613	9.556699e-01	0.020	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.556699e-01	0.020	0	0
Triglyceride biosynthesis	R-HSA-75109	9.556699e-01	0.020	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.556699e-01	0.020	0	0
Surfactant metabolism	R-HSA-5683826	9.564826e-01	0.019	0	0
Aquaporin-mediated transport	R-HSA-445717	9.575471e-01	0.019	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.596684e-01	0.018	0	0
Pyroptosis	R-HSA-5620971	9.596684e-01	0.018	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.597773e-01	0.018	0	0
Signaling by PDGF	R-HSA-186797	9.604203e-01	0.018	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.604203e-01	0.018	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.610907e-01	0.017	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.628320e-01	0.016	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.628320e-01	0.016	0	0
Protein folding	R-HSA-391251	9.631428e-01	0.016	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.633064e-01	0.016	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.633064e-01	0.016	0	0
PPARA activates gene expression	R-HSA-1989781	9.637721e-01	0.016	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.657327e-01	0.015	0	0
DAP12 signaling	R-HSA-2424491	9.666164e-01	0.015	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.666164e-01	0.015	0	0
Neurotransmitter clearance	R-HSA-112311	9.666164e-01	0.015	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.670838e-01	0.015	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.683031e-01	0.014	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.696280e-01	0.013	0	0
Cargo concentration in the ER	R-HSA-5694530	9.696280e-01	0.013	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.696280e-01	0.013	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.723681e-01	0.012	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.723681e-01	0.012	0	0
HS-GAG degradation	R-HSA-2024096	9.723681e-01	0.012	0	0
Azathioprine ADME	R-HSA-9748787	9.729651e-01	0.012	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.741629e-01	0.011	0	0
Formation of the cornified envelope	R-HSA-6809371	9.748285e-01	0.011	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.748612e-01	0.011	0	0
Recycling of bile acids and salts	R-HSA-159418	9.748612e-01	0.011	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.787560e-01	0.009	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.791931e-01	0.009	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.791931e-01	0.009	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.810707e-01	0.008	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.810707e-01	0.008	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.819281e-01	0.008	0	0
Paracetamol ADME	R-HSA-9753281	9.819281e-01	0.008	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.820349e-01	0.008	0	0
Translation	R-HSA-72766	9.823376e-01	0.008	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.827790e-01	0.008	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.827790e-01	0.008	0	0
Glycosphingolipid transport	R-HSA-9845576	9.827790e-01	0.008	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.827790e-01	0.008	0	0
G1/S-Specific Transcription	R-HSA-69205	9.827790e-01	0.008	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.827790e-01	0.008	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.828930e-01	0.007	0	0
Immune System	R-HSA-168256	9.832081e-01	0.007	0	0
tRNA processing	R-HSA-72306	9.835952e-01	0.007	0	0
Peptide hormone metabolism	R-HSA-2980736	9.840728e-01	0.007	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.843332e-01	0.007	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.843332e-01	0.007	0	0
Lysine catabolism	R-HSA-71064	9.843332e-01	0.007	0	0
Collagen chain trimerization	R-HSA-8948216	9.843332e-01	0.007	0	0
Metabolism of folate and pterines	R-HSA-196757	9.843332e-01	0.007	0	0
Elastic fibre formation	R-HSA-1566948	9.857472e-01	0.006	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.857520e-01	0.006	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.866065e-01	0.006	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.869515e-01	0.006	0	0
Signaling by ALK	R-HSA-201556	9.870337e-01	0.006	0	0
tRNA Aminoacylation	R-HSA-379724	9.879771e-01	0.005	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.882041e-01	0.005	0	0
Gastrulation	R-HSA-9758941	9.887241e-01	0.005	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.888937e-01	0.005	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.889240e-01	0.005	0	0
Collagen degradation	R-HSA-1442490	9.889240e-01	0.005	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.892689e-01	0.005	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.902377e-01	0.004	0	0
Potassium Channels	R-HSA-1296071	9.905140e-01	0.004	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.911191e-01	0.004	0	0
Pyrimidine catabolism	R-HSA-73621	9.919209e-01	0.004	0	0
Proteasome assembly	R-HSA-9907900	9.926504e-01	0.003	0	0
DAP12 interactions	R-HSA-2172127	9.926504e-01	0.003	0	0
Amine ligand-binding receptors	R-HSA-375280	9.926504e-01	0.003	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.926680e-01	0.003	0	0
Nicotinate metabolism	R-HSA-196807	9.932517e-01	0.003	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.932517e-01	0.003	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.933141e-01	0.003	0	0
Somitogenesis	R-HSA-9824272	9.933141e-01	0.003	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.934721e-01	0.003	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.936275e-01	0.003	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.936275e-01	0.003	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.936772e-01	0.003	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.947429e-01	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.947429e-01	0.002	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.949668e-01	0.002	0	0
ECM proteoglycans	R-HSA-3000178	9.951641e-01	0.002	0	0
Retinoid metabolism and transport	R-HSA-975634	9.951641e-01	0.002	0	0
Neurotransmitter release cycle	R-HSA-112310	9.953415e-01	0.002	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.954214e-01	0.002	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.954214e-01	0.002	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.955521e-01	0.002	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.955937e-01	0.002	0	0
Phospholipid metabolism	R-HSA-1483257	9.958282e-01	0.002	0	0
Complex IV assembly	R-HSA-9864848	9.962112e-01	0.002	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.962112e-01	0.002	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.968320e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.970837e-01	0.001	0	0
Cholesterol biosynthesis	R-HSA-191273	9.973141e-01	0.001	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.974910e-01	0.001	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.975317e-01	0.001	0	0
Dectin-2 family	R-HSA-5621480	9.978534e-01	0.001	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.978539e-01	0.001	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.979161e-01	0.001	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.980156e-01	0.001	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.980452e-01	0.001	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.980452e-01	0.001	0	0
Visual phototransduction	R-HSA-2187338	9.981881e-01	0.001	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.982239e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.983844e-01	0.001	0	0
Glutathione conjugation	R-HSA-156590	9.983844e-01	0.001	0	0
Metabolism of polyamines	R-HSA-351202	9.983844e-01	0.001	0	0
Endogenous sterols	R-HSA-211976	9.985304e-01	0.001	0	0
Mitochondrial protein import	R-HSA-1268020	9.986632e-01	0.001	0	0
Post-translational protein modification	R-HSA-597592	9.987765e-01	0.001	0	0
Complex I biogenesis	R-HSA-6799198	9.987841e-01	0.001	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.988940e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.988945e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.991279e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.991677e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.992328e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.994303e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.994697e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.994818e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.994863e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.995713e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.997066e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.998031e-01	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	9.998290e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.998340e-01	0.000	0	0
Disease	R-HSA-1643685	9.998607e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.998983e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999096e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999145e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999415e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999454e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999560e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999600e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999669e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999704e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999794e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999825e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999834e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999894e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999904e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999913e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999916e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999958e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999961e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999965e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999977e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999981e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999987e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999988e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999988e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999991e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999993e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999994e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999995e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999996e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999996e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999997e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999998e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999999e-01	0.000	1	0
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.999999e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0