CDK6

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00151 S90 Sugiyama PDLIM1 CLIM1 CLP36 IKGCTDNLtLtVARsEHKVWsPLVtEEGKRHPYKMNLASEP
O14745 S280 Sugiyama NHERF1 NHERF SLC9A3R1 tNGEIQKENsREALAEAALEsPRPALVRsAssDtsEELNsQ
O14910 S130 Sugiyama LIN7A MALS1 VELI1 ELPKTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLK
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852 T65 Sugiyama CALU FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60292 S158 Sugiyama SIPA1L3 KIAA0545 SPAL3 FHRLSRRRsKDVEFQDGWPRsPGRAFLPLRHRsssEItLSE
O95425 S245 Sugiyama SVIL EsssTFsFSGRDssFtEVPRsPKHAHSssLQQAAsRsPsFG
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P03973 T78 Sugiyama SLPI WAP4 WFDC4 PGKKRCCPDTCGIKCLDPVDtPNPTRRKPGKCPVTYGQCLM
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04083 S170 Sugiyama ANXA1 ANX1 LPC1 RDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsE
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06400 S249 PSP RB1 LsPPMLLKEPYKTAVIPINGsPRtPRRGQNRSARIAKQLEN
P06400 S612 EPSD|PSP RB1 LNLPLQNNHtAADMyLsPVRsPKKKGSTTRVNstANAETQA
P06400 S780 EPSD|PSP RB1 FMQRLKtNILQyAstRPPtLsPIPHIPRsPyKFPssPLRIP
P06400 S788 EPSD|PSP RB1 ILQyAstRPPtLsPIPHIPRsPyKFPssPLRIPGGNIyIsP
P06400 S795 EPSD|PSP RB1 RPPtLsPIPHIPRsPyKFPssPLRIPGGNIyIsPLKsPYKI
P06400 S807 EPSD|PSP RB1 RsPyKFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtP
P06400 S811 SIGNOR|EPSD|PSP RB1 KFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtPRSRI
P06400 T252 PSP RB1 PMLLKEPYKTAVIPINGsPRtPRRGQNRSARIAKQLENDTR
P06400 T821 GPS6|EPSD|PSP RB1 GGNIyIsPLKsPYKIsEGLPtPtKMtPRSRILVSIGEsFGt
P06400 T826 EPSD|PSP RB1 IsPLKsPYKIsEGLPtPtKMtPRSRILVSIGEsFGtsEKFQ
P06733 S263 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GMDVAASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsF
P06733 S272 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 FRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsI
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06748 T199 GPS6|EPSD|PSP NPM1 NPM DDFDDEEAEEKAPVKKsIRDtPAKNAQKSNQNGKDsKPsst
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07858 S216 Sugiyama CTSB CPSB PPCTGEGDTPKCSKICEPGysPtyKQDKHYGYNSYSVSNSE
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09234 S17 Sugiyama SNRPC ____MPKFyCDyCDtyLtHDsPsVRKTHCSGRKHKENVKDY
P10809 S453 Sugiyama HSPD1 HSP60 EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P12270 S2155 Sugiyama TPR PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P12277 T35 Sugiyama CKB CKBB PAEDEFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDD
P12277 Y39 Sugiyama CKB CKBB EFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDDVIQT
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 S595 Sugiyama EEF2 EF2 PVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGLAE
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S37 SIGNOR|PSP PKM OIP3 PK2 PK3 PKM2 QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P18669 S31 Sugiyama PGAM1 PGAMA CDABP0006 HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P18858 S51 Sugiyama LIG1 TEPPPKAALKEWNGVVsEsDsPVKRPGRKAARVLGsEGEEE
P19484 S114 PSP TFEB BHLHE35 EYLsEtYGNKFAAHIsPAQGsPKPPPAAsPGVRAGHVLSss
P19484 S142 PSP TFEB BHLHE35 sPGVRAGHVLSssAGNsAPNsPMAMLHIGsNPERELDDVID
P19484 S467 PSP TFEB BHLHE35 SDPLLstMsPEAsKAssRRssFsMEEGDVL___________
P19484 T331 PSP TFEB BHLHE35 QLWLRIQELEMQARVHGLPttsPsGMNMAELAQQVVKQELP
P19532 S246 PSP TFE3 BHLHE33 QPLPAPEAAHTTGPTGSAPNsPMALLTIGSSSEKEIDDVID
P21333 S1084 Sugiyama FLNA FLN FLN1 PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P21333 S1459 PSP FLNA FLN FLN1 KVPVHDVTDASKVKCsGPGLsPGMVRANLPQsFQVDTSKAG
P21333 S2152 PSP FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22626 S259 Sugiyama HNRNPA2B1 HNRPA2B1 GFGDGyNGyGGGPGGGNFGGsPGyGGGRGGYGGGGPGYGNQ
P23396 T220 Sugiyama RPS3 OK/SW-cl.26 PKKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPV
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P25205 T722 Sugiyama MCM3 GDsyDPyDFsDtEEEMPQVHtPKTADsQEtKEsQKVELsES
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27824 S583 Sugiyama CANX VsQEEEDRKPKAEEDEILNRsPRNRKPRRE___________
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401 T287 Sugiyama TKT AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P29692 S133 Sugiyama EEF1D EF1D NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29966 S29 Sugiyama MARCKS MACS PRKCSL AAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsPAA
P30086 T42 Sugiyama PEBP1 PBP PEBP QHPLHVTYAGAAVDELGKVLtPtQVKNRPtsIsWDGLDsGK
P30281 S133 Sugiyama CCND3 LRETtPLtIEKLCIYtDHAVsPRQLRDWEVLVLGKLKWDLA
P30281 S275 Sugiyama CCND3 LREASQTSssPAPKAPRGsssQGPsQtstPtDVtAIHL___
P30281 S279 Sugiyama CCND3 SQTSssPAPKAPRGsssQGPsQtstPtDVtAIHL_______
P30281 S282 Sugiyama CCND3 SssPAPKAPRGsssQGPsQtstPtDVtAIHL__________
P30281 S43 Sugiyama CCND3 GDQRVLQSLLRLEERyVPRAsyFQCVQREIKPHMRKMLAYW
P30281 T120 Sugiyama CCND3 QLLGAVCMLLASKLRETtPLtIEKLCIYtDHAVsPRQLRDW
P30281 T283 Sugiyama CCND3 ssPAPKAPRGsssQGPsQtstPtDVtAIHL___________
P30281 T285 Sugiyama CCND3 PAPKAPRGsssQGPsQtstPtDVtAIHL_____________
P30281 T288 Sugiyama CCND3 KAPRGsssQGPsQtstPtDVtAIHL________________
P30281 Y38 Sugiyama CCND3 DPRLLGDQRVLQSLLRLEERyVPRAsyFQCVQREIKPHMRK
P30281 Y44 Sugiyama CCND3 DQRVLQSLLRLEERyVPRAsyFQCVQREIKPHMRKMLAYWM
P30304 S40 SIGNOR CDC25A PPASQPVVKALFGASAAGGLsPVTNLTVTMDQLQGLGSDyE
P30304 S88 SIGNOR CDC25A NSNLQRMGsSEstDsGFCLDsPGPLDSKENLENPMRRIHsL
P31943 T100 Sugiyama HNRNPH1 HNRPH HNRPH1 HRyVEVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35222 S45 SIGNOR|iPTMNet CTNNB1 CTNNB OK/SW-cl.35 PRO2286 WQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDVDTsQVLyE
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P38936 S130 SIGNOR|EPSD|PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 HVDLsLSCTLVPRsGEQAEGsPGGPGDSQGRKRRQtsMTDF
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P46527 S10 SIGNOR|EPSD|PSP CDKN1B KIP1 p27 ___________MSNVRVSNGsPsLERMDARQAEHPKPSACR
P46527 T187 SIGNOR|EPSD|PSP CDKN1B KIP1 p27 ANRTEENVsDGsPNAGSVEQtPKKPGLRRRQt_________
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46937 T119 Sugiyama YAP1 YAP65 PEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQLGAVsP
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49736 T25 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sEsFtMAssPAQRRRGNDPLtssPGRssRRtDALtssPGRD
P49815 S1217 SIGNOR|PSP TSC2 TSC4 ILVRRPTGNTSWLMSLENPLsPFSSDINNMPLQELSNALMA
P49815 S1452 SIGNOR|PSP TSC2 TSC4 ASGEDSRGQPEGPLPsssPRsPsGLRPRGYtIsDsAPsRRG
P51812 S715 Sugiyama RPS6KA3 ISPK1 MAPKAPK1B RSK2 APHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQRRGIKKI
P51991 S358 Sugiyama HNRNPA3 HNRPA3 QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55795 T100 Sugiyama HNRNPH2 FTP3 HNRPH2 HRyVEVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174 T46 Sugiyama TPI1 TPI IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61247 S263 Sugiyama RPS3A FTE1 MFTL GDEtGAKVERADGyEPPVQEsV___________________
P61978 S284 Sugiyama HNRNPK HNRPK MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62942 S9 Sugiyama FKBP1A FKBP1 FKBP12 ____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 T52 Sugiyama RPL24 LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P83731 Y55 Sugiyama RPL24 KCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRTRRA
P85037 S420 Sugiyama FOXK1 MNF RGVSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECL
P85037 S428 Sugiyama FOXK1 MNF PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
P85037 T422 Sugiyama FOXK1 MNF VSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsR
Q00534 S138 Sugiyama CDK6 CDKN6 PTETIKDMMFQLLRGLDFLHsHRVVHRDLKPQNILVTSSGQ
Q00534 S312 Sugiyama CDK6 CDKN6 ysALSHPyFQDLERCKENLDsHLPPsQNtsELNtA______
Q00534 S317 Sugiyama CDK6 CDKN6 HPyFQDLERCKENLDsHLPPsQNtsELNtA___________
Q00534 S321 Sugiyama CDK6 CDKN6 QDLERCKENLDsHLPPsQNtsELNtA_______________
Q00534 S57 Sugiyama CDK6 CDKN6 GRFVALKRVRVQtGEEGMPLsTIREVAVLRHLEtFEHPNVV
Q00534 T267 Sugiyama CDK6 CDKN6 VALPRQAFHSKSAQPIEKFVtDIDELGKDLLLKCLtFNPAK
Q00534 T282 Sugiyama CDK6 CDKN6 IEKFVtDIDELGKDLLLKCLtFNPAKRIsAysALSHPyFQD
Q00534 T325 Sugiyama CDK6 CDKN6 RCKENLDsHLPPsQNtsELNtA___________________
Q00534 T49 Sugiyama CDK6 CDKN6 KARDLKNGGRFVALKRVRVQtGEEGMPLsTIREVAVLRHLE
Q00534 T70 Sugiyama CDK6 CDKN6 GEEGMPLsTIREVAVLRHLEtFEHPNVVRLFDVCTVSRTDR
Q00534 Y13 Sugiyama CDK6 CDKN6 ________MEKDGLCRADQQyECVAEIGEGAyGKVFKARDL
Q00534 Y24 Sugiyama CDK6 CDKN6 DGLCRADQQyECVAEIGEGAyGKVFKARDLKNGGRFVALKR
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01196 S21 SIGNOR RUNX1 AML1 CBFA2 MRIPVDASTSRRFtPPstALsPGKMsEALPLGAPDAGAALA
Q01196 S249 SIGNOR RUNX1 AML1 CBFA2 stAFNPQPQSQMQDTRQIQPsPPWsyDQsyQyLGSIAsPsV
Q01196 S266 SIGNOR RUNX1 AML1 CBFA2 IQPsPPWsyDQsyQyLGSIAsPsVHPAtPIsPGRASGMTTL
Q01196 S276 SIGNOR RUNX1 AML1 CBFA2 QsyQyLGSIAsPsVHPAtPIsPGRASGMTTLSAELSSRLsT
Q01196 S397 SIGNOR RUNX1 AML1 CBFA2 HLYYGASAGSYQFSMVGGERsPPRILPPCTNASTGSALLNP
Q01196 T273 SIGNOR RUNX1 AML1 CBFA2 syDQsyQyLGSIAsPsVHPAtPIsPGRASGMTTLSAELSSR
Q01813 S679 SIGNOR PFKP PFKF KGVFDCRKNVLGHMQQGGAPsPFDRNFGTKISARAMEWITA
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q06830 T90 SIGNOR PRDX1 PAGA PAGB TDPX2 NCQVIGASVDSHFCHLAWVNtPKKQGGLGPMNIPLVSDPKR
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q08050 S451 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN APLSSAGPGKEEKLLFGEGFsPLLPVQTIKEEEIQPGEEMP
Q08050 S489 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN EMPHLARPIKVEsPPLEEWPsPAPSFKEEssHsWEDssQsP
Q08050 S508 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN PsPAPSFKEEssHsWEDssQsPtPRPKKSYSGLRsPTRCVS
Q08050 S522 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN WEDssQsPtPRPKKSYSGLRsPTRCVSEMLVIQHRERRERS
Q08050 S704 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN LIsVPFGNssPsDIDVPKPGsPEPQVsGLAANRsLtEGLVL
Q08050 T510 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN PAPSFKEEssHsWEDssQsPtPRPKKSYSGLRsPTRCVSEM
Q08050 T600 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN DSSDPASQLSYSQEVGGPFKtPIKETLPISStPsKSVLPRt
Q08050 T611 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN SQEVGGPFKtPIKETLPISStPsKSVLPRtPEsWRLtPPAK
Q08050 T620 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN tPIKETLPISStPsKSVLPRtPEsWRLtPPAKVGGLDFsPV
Q08050 T627 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN PISStPsKSVLPRtPEsWRLtPPAKVGGLDFsPVQTSQGAS
Q08999 S1035 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RBL2 RB2 KQIKTFAMKYSQANMDAPPLsPYPFVRtGsPRRIQLSQNHP
Q08999 S672 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RBL2 RB2 DTGGLGRsItsPTtLyDRYssPPAStTRRRLFVENDsPsDG
Q08999 T401 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RBL2 RB2 VQMKNILQQHFDKSKALRIStPLTGVRyIKENsPCVtPVST
Q08AD1 S1319 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 NEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWENAstts
Q13200 S16 Sugiyama PSMD2 TRAP2 _____MEEGGRDKAPVQPQQsPAAAPGGtDEKPsGKERRDA
Q13242 S211 Sugiyama SRSF9 SFRS9 SRP30C GYsRsRSGsRGRDsPyQsRGsPHyFsPFRPy__________
Q13242 S216 Sugiyama SRSF9 SFRS9 SRP30C RSGsRGRDsPyQsRGsPHyFsPFRPy_______________
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13428 T1014 Sugiyama TCOF1 ARssssEsEDEDVIPAtQCLtPGIRTNVVTMPTAHPRIAPK
Q13573 S224 Sugiyama SNW1 SKIIP SKIP KDPMEPPRFKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQE
Q13573 S232 Sugiyama SNW1 SKIIP SKIP FKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQEWKIPPCIS
Q14157 S416 Sugiyama UBAP2L KIAA0144 NICE4 tQsPsLVQYDLKNPsDsAVHsPFtKRQAFtPsstMMEVFLQ
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14847 T104 Sugiyama LASP1 MLN50 VRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsNIKyHE
Q14980 S1757 Sugiyama NUMA1 NMP22 NUMA ITSKLPRtQPDGtsVPGEPAsPIsQRLPPKVEsLEsLyFtP
Q15154 S69 Sugiyama PCM1 KKKFGVESDKRVTNDISPESsPGVGRRRTKTPHTFPHSRYM
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15642 T302 Sugiyama TRIP10 CIP4 STOT STP VEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWP
Q15717 S202 PSP ELAVL1 HUR KFAANPNQNKNVALLsQLyHsPARRFGGPVHHQAQRFRFsP
Q16204 S244 Sugiyama CCDC6 D10S170 TST1 LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16875 S467 PSP PFKFB3 EDAKKGPNPLMRRNsVtPLAsPEPtKKPRINsFEEHVASTS
Q16875 T463 PSP PFKFB3 RERSEDAKKGPNPLMRRNsVtPLAsPEPtKKPRINsFEEHV
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q5T4S7 S178 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 AKLPQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLT
Q5T4S7 S181 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 PQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLTSVF
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q6P1L8 S49 Sugiyama MRPL14 MRPL32 RPML32 LSAIQKMTRVRVVDNSALGNsPyHRAPRCIHVYKKNGVGKV
Q6PKG0 S774 Sugiyama LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6XUX3 S483 Sugiyama DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P QIQELIISRLNQAVANKLISsVDyLRESFVGtLERCLQSLE
Q6XUX3 T494 Sugiyama DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P QAVANKLISsVDyLRESFVGtLERCLQSLEKSQDVSVHITS
Q6XUX3 Y486 Sugiyama DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P ELIISRLNQAVANKLISsVDyLRESFVGtLERCLQSLEKSQ
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7L2J0 S216 Sugiyama MEPCE BCDIN3 NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0 T213 Sugiyama MEPCE BCDIN3 DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z417 S692 Sugiyama NUFIP2 KIAA1321 PIG1 IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N556 S265 Sugiyama AFAP1 AFAP KEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssDG
Q8N556 S668 Sugiyama AFAP1 AFAP AGGVTLGLAIEPKsGtssPQsPVFRHRtLENsPIssCDtsD
Q8NBJ5 S612 Sugiyama COLGALT1 GLT25D1 PSEC0241 QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8WXI9 S135 Sugiyama GATAD2B KIAA1150 ERGRLtPsPDIIVLsDNEAssPRsSsRMEERLKAANLEMFK
Q8WXI9 T120 Sugiyama GATAD2B KIAA1150 INDEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSs
Q92879 S302 EPSD|PSP CELF1 BRUNOL2 CUGBP CUGBP1 NAB50 NALTTSSSPLSVLTSSGSsPsSSSSNSVNPIASLGALQTLA
Q96B36 S212 Sugiyama AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96C90 S32 Sugiyama PPP1R14B PLCB3N PNG LAAPAPGPGsGGPGPRVyFQsPPGAAGEGPGGADDEGPVRR
Q96KS0 S130 EPSD|PSP EGLN2 EIT6 QGARPEAPKRKWAEDGGDAPsPsKRPWARQENQEAEREGGM
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BX68 T47 Sugiyama HINT2 QVRGAAGVTDGNEVAKAQQAtPGGAAPtIFsRILDKsLPAD
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9GZM8 T245 SIGNOR NDEL1 EOPA MITAP1 NUDEL TENTFPsPKAIPNGFGTsPLtPSARIsALNIVGDLLRKVGA
Q9H1E3 S214 Sugiyama NUCKS1 NUCKS JC7 AsKAsKEKtPsPKEEDEEPEsPPEKKtstsPPPEKsGDEGs
Q9H3K6 T76 Sugiyama BOLA2 BOLA2A My016; BOLA2B VNACLAEELPHIHAFEQKTLtPDQWARERQK__________
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H773 S85 Sugiyama DCTPP1 XTP3TPA CDA03 GELAELFQWKTDGEPGPQGWsPRERAALQEELSDVLIYLVA
Q9HAP6 S115 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 ELPKTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLK
Q9NS64 S98 PSP RPRM CNLLIKSEGMINFLVKDRRPsKEVEAVVVGPY_________
Q9NUP9 S115 Sugiyama LIN7C MALS3 VELI3 ELPKTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLK
Q9NYB0 S203 Sugiyama TERF2IP DRIP5 RAP1 PP8000 RYLKHLRGQEHKyLLGDAPVsPssQKLKRKAEEDPEAADsG
Q9NZB2 T991 Sugiyama FAM120A C9orf10 KIAA0183 OSSA PLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKNQ
Q9NZT2 S378 Sugiyama OGFR LERsQGDEAGGHGEDRPEPLsPKEsKKRKLELSRREQPPTE
Q9UKV3 S388 Sugiyama ACIN1 ACINUS KIAA0670 EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9UQ35 S1110 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsAsPMLKsG
Q9UQ35 S2694 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 RSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQSSs
Q9Y2B0 S127 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 RVVGRNGEssELDLQGIRIDsDISGtLKFACEsIVEEyEDE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Q9Y2V2 S41 Sugiyama CARHSP1 LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y2W1 S243 Sugiyama THRAP3 BCLAF2 TRAP150 WPDAtyGtGsAsRAsAVsELsPRERsPALKsPLQsVVVRRR
Q9Y6G9 T513 Sugiyama DYNC1LI1 DNCLI1 LDVHAELDRITRKPVtVsPttPtsPtEGEAs__________
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 9.606486e-10 9.017 1 0
Cell Cycle R-HSA-1640170 6.767508e-10 9.170 1 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.189163e-07 6.143 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.129741e-06 5.672 0 0
G0 and Early G1 R-HSA-1538133 2.384486e-06 5.623 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.096740e-06 5.509 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.776629e-06 5.321 0 0
Chromatin organization R-HSA-4839726 6.124294e-06 5.213 0 0
Chromatin modifying enzymes R-HSA-3247509 1.150857e-05 4.939 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.201495e-05 4.657 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.515041e-05 4.599 0 0
Cell Cycle Checkpoints R-HSA-69620 6.490561e-05 4.188 0 0
S Phase R-HSA-69242 9.352903e-05 4.029 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.044104e-04 3.981 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.643138e-04 3.784 0 0
G1/S-Specific Transcription R-HSA-69205 1.979010e-04 3.704 0 0
Polo-like kinase mediated events R-HSA-156711 3.719199e-04 3.430 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.585507e-04 3.445 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.585507e-04 3.445 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.269095e-04 3.486 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 9.186291e-04 3.037 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.038509e-03 2.984 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 1.161670e-03 2.935 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 1.161670e-03 2.935 0 0
NRAGE signals death through JNK R-HSA-193648 1.175721e-03 2.930 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.224703e-03 2.912 1 0
Disorders of Developmental Biology R-HSA-9675151 1.328367e-03 2.877 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.676232e-03 2.776 0 0
Deadenylation of mRNA R-HSA-429947 1.713398e-03 2.766 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.566744e-03 2.805 1 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.494416e-03 2.826 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.838280e-03 2.736 0 0
Separation of Sister Chromatids R-HSA-2467813 1.817529e-03 2.741 0 0
HATs acetylate histones R-HSA-3214847 1.692475e-03 2.771 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.678455e-03 2.775 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.643900e-03 2.784 0 0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells R-HSA-210746 1.781025e-03 2.749 0 0
Mitotic Anaphase R-HSA-68882 2.221946e-03 2.653 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.218217e-03 2.654 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.346146e-03 2.630 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.598456e-03 2.585 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.945966e-03 2.531 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.945966e-03 2.531 0 0
Gene expression (Transcription) R-HSA-74160 3.602326e-03 2.443 1 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.642000e-03 2.439 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.798414e-03 2.420 0 0
Apoptotic execution phase R-HSA-75153 3.882136e-03 2.411 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.625676e-03 2.335 1 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.609473e-03 2.336 0 0
M Phase R-HSA-68886 4.813023e-03 2.318 0 0
Cellular Senescence R-HSA-2559583 4.987701e-03 2.302 1 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 5.795302e-03 2.237 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.579902e-03 2.253 0 0
HIV Life Cycle R-HSA-162587 5.500623e-03 2.260 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.037002e-03 2.153 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.037002e-03 2.153 0 0
Nuclear RNA decay R-HSA-9930044 7.035818e-03 2.153 0 0
G1/S Transition R-HSA-69206 6.526325e-03 2.185 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.903735e-03 2.161 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.037002e-03 2.153 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.808212e-03 2.167 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.884454e-03 2.103 0 0
Homology Directed Repair R-HSA-5693538 8.673503e-03 2.062 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.009427e-03 2.045 0 0
Nuclear import of Rev protein R-HSA-180746 9.092009e-03 2.041 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.000011e-02 2.000 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.012631e-02 1.995 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 9.914305e-03 2.004 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.878114e-03 2.005 0 0
G alpha (12/13) signalling events R-HSA-416482 1.030863e-02 1.987 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.046460e-02 1.980 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.066977e-02 1.972 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.199310e-02 1.921 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.312527e-02 1.882 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.399067e-02 1.854 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.312527e-02 1.882 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.312527e-02 1.882 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.312527e-02 1.882 0 0
G2/M Transition R-HSA-69275 1.327046e-02 1.877 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.456828e-02 1.837 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.447259e-02 1.839 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.309450e-02 1.883 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.383463e-02 1.859 0 0
Signaling by NTRKs R-HSA-166520 1.402116e-02 1.853 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.458505e-02 1.836 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.458505e-02 1.836 0 0
Frs2-mediated activation R-HSA-170968 1.602200e-02 1.795 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.611169e-02 1.793 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.636662e-02 1.786 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.746176e-02 1.758 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.742858e-02 1.759 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.808765e-02 1.743 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.921011e-02 1.716 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.921011e-02 1.716 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.921011e-02 1.716 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.006331e-02 1.698 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.977650e-02 1.704 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.977650e-02 1.704 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.890464e-02 1.723 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.024141e-02 1.694 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.168854e-02 1.664 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.455340e-02 1.610 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.455340e-02 1.610 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.316021e-02 1.635 0 0
HIV Infection R-HSA-162906 2.435172e-02 1.613 0 0
Signaling by TGFB family members R-HSA-9006936 2.523751e-02 1.598 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.321388e-02 1.634 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.647193e-02 1.577 0 0
Phosphorylation of the APC/C R-HSA-176412 2.698775e-02 1.569 0 0
Prolonged ERK activation events R-HSA-169893 2.698775e-02 1.569 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.698775e-02 1.569 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.760109e-02 1.559 0 0
Nucleosome assembly R-HSA-774815 3.139533e-02 1.503 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.139533e-02 1.503 0 0
G1 Phase R-HSA-69236 2.877496e-02 1.541 1 0
Cyclin D associated events in G1 R-HSA-69231 2.877496e-02 1.541 1 1
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.953876e-02 1.530 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.990939e-02 1.524 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.143280e-02 1.503 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.239873e-02 1.489 0 0
Signalling to ERKs R-HSA-187687 3.239873e-02 1.489 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.245707e-02 1.489 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.542333e-02 1.451 0 0
Death Receptor Signaling R-HSA-73887 3.575754e-02 1.447 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.912637e-02 1.408 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.979093e-02 1.400 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.979093e-02 1.400 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.979093e-02 1.400 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.979093e-02 1.400 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.979093e-02 1.400 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.911733e-02 1.408 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.019989e-02 1.396 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.019989e-02 1.396 0 0
Circadian clock R-HSA-9909396 4.217215e-02 1.375 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.268247e-02 1.370 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.379757e-02 1.359 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.379757e-02 1.359 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.399399e-02 1.357 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 4.507575e-02 1.346 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.507575e-02 1.346 0 0
Metabolism of RNA R-HSA-8953854 4.522481e-02 1.345 0 0
Heme signaling R-HSA-9707616 4.570957e-02 1.340 0 0
Signaling by AXIN mutants R-HSA-4839735 5.301234e-02 1.276 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.077407e-02 1.294 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.077407e-02 1.294 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.793832e-02 1.319 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.327618e-02 1.273 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.354339e-02 1.271 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 5.435869e-02 1.265 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 5.435869e-02 1.265 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 5.435869e-02 1.265 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.918140e-02 1.228 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.182248e-02 1.209 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.182248e-02 1.209 0 0
Disorders of Nervous System Development R-HSA-9697154 6.182248e-02 1.209 0 0
Pervasive developmental disorders R-HSA-9005895 6.182248e-02 1.209 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.877660e-02 1.231 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.877660e-02 1.231 0 0
mRNA 3'-end processing R-HSA-72187 5.423566e-02 1.266 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.794406e-02 1.237 0 0
Repression of WNT target genes R-HSA-4641265 6.182248e-02 1.209 0 0
Mitotic Prometaphase R-HSA-68877 5.612727e-02 1.251 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.508021e-02 1.259 0 0
G2/M Checkpoints R-HSA-69481 5.994787e-02 1.222 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 5.918140e-02 1.228 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.975066e-02 1.224 0 0
Signaling by WNT in cancer R-HSA-4791275 6.429134e-02 1.192 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.662315e-02 1.176 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.680347e-02 1.175 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.457545e-02 1.127 0 0
Phosphorylation of Emi1 R-HSA-176417 7.457545e-02 1.127 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 7.457545e-02 1.127 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.008624e-02 1.154 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.008624e-02 1.154 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.927795e-02 1.101 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.927795e-02 1.101 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.615909e-02 1.118 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.615909e-02 1.118 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.008624e-02 1.154 0 0
Synthesis of DNA R-HSA-69239 7.485198e-02 1.126 0 0
Interleukin-6 signaling R-HSA-1059683 7.126460e-02 1.147 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 7.457545e-02 1.127 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.126460e-02 1.147 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.485198e-02 1.126 0 0
Signaling by ALK in cancer R-HSA-9700206 7.485198e-02 1.126 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.126460e-02 1.147 0 0
Mitotic Prophase R-HSA-68875 7.776227e-02 1.109 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.615909e-02 1.118 0 0
Cardiogenesis R-HSA-9733709 7.008624e-02 1.154 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.388700e-02 1.131 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.388700e-02 1.131 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.040651e-02 1.095 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.130982e-02 1.090 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.130982e-02 1.090 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.130982e-02 1.090 0 0
RAF activation R-HSA-5673000 8.250691e-02 1.084 0 0
snRNP Assembly R-HSA-191859 8.537109e-02 1.069 0 0
Metabolism of non-coding RNA R-HSA-194441 8.537109e-02 1.069 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.537109e-02 1.069 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.057656e-01 0.976 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.057656e-01 0.976 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.057656e-01 0.976 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.057656e-01 0.976 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.057656e-01 0.976 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.057656e-01 0.976 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.057656e-01 0.976 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.057656e-01 0.976 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.057656e-01 0.976 0 0
G2/M DNA replication checkpoint R-HSA-69478 9.107650e-02 1.041 0 0
Translesion synthesis by REV1 R-HSA-110312 9.192698e-02 1.037 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.192698e-02 1.037 0 0
Translesion synthesis by POLI R-HSA-5656121 1.030831e-01 0.987 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.120905e-02 1.040 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.476158e-02 1.023 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.831443e-02 1.054 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.874707e-02 1.005 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.874707e-02 1.005 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.874707e-02 1.005 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.302767e-02 1.031 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 9.107650e-02 1.041 0 0
Signaling by NOTCH1 R-HSA-1980143 1.029418e-01 0.987 0 0
DCC mediated attractive signaling R-HSA-418885 9.192698e-02 1.037 0 0
RNA Polymerase II Transcription R-HSA-73857 1.054351e-01 0.977 1 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.793854e-02 1.009 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.793854e-02 1.009 0 0
NGF-stimulated transcription R-HSA-9031628 9.721478e-02 1.012 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.192698e-02 1.037 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.031593e-01 0.986 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.066734e-01 0.972 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.066734e-01 0.972 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.075004e-01 0.969 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.085190e-01 0.964 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.085190e-01 0.964 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 1.543809e-01 0.811 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 1.543809e-01 0.811 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.543809e-01 0.811 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 1.543809e-01 0.811 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 2.003560e-01 0.698 0 0
Defective OPLAH causes OPLAHD R-HSA-5578998 2.003560e-01 0.698 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 2.003560e-01 0.698 0 0
MET activates PTPN11 R-HSA-8865999 2.438341e-01 0.613 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 2.438341e-01 0.613 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 2.438341e-01 0.613 0 0
Classical Kir channels R-HSA-1296053 2.438341e-01 0.613 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 2.438341e-01 0.613 0 0
MET receptor recycling R-HSA-8875656 1.267521e-01 0.897 0 0
ALK mutants bind TKIs R-HSA-9700645 1.456386e-01 0.837 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.849507e-01 0.545 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.849507e-01 0.545 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.849507e-01 0.545 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.849507e-01 0.545 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.849507e-01 0.545 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.849507e-01 0.545 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.650537e-01 0.782 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.650537e-01 0.782 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.650537e-01 0.782 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.147440e-01 0.940 0 0
Translesion synthesis by POLK R-HSA-5655862 1.147440e-01 0.940 0 0
Signaling by APC mutants R-HSA-4839744 1.848843e-01 0.733 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.848843e-01 0.733 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.848843e-01 0.733 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.848843e-01 0.733 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 3.238339e-01 0.490 0 0
IRS activation R-HSA-74713 3.238339e-01 0.490 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.238339e-01 0.490 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.238339e-01 0.490 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.268745e-01 0.897 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.050282e-01 0.688 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.050282e-01 0.688 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.394389e-01 0.856 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.524014e-01 0.817 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.253926e-01 0.647 0 0
Polymerase switching R-HSA-69091 2.253926e-01 0.647 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.253926e-01 0.647 0 0
Leading Strand Synthesis R-HSA-69109 2.253926e-01 0.647 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.253926e-01 0.647 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.253926e-01 0.647 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.253926e-01 0.647 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.253926e-01 0.647 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.606049e-01 0.443 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.657262e-01 0.781 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.657262e-01 0.781 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.657262e-01 0.781 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.657262e-01 0.781 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.458943e-01 0.609 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.458943e-01 0.609 1 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.458943e-01 0.609 1 1
Lagging Strand Synthesis R-HSA-69186 1.793777e-01 0.746 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.933209e-01 0.714 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.664583e-01 0.574 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.953784e-01 0.403 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.953784e-01 0.403 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.953784e-01 0.403 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.953784e-01 0.403 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.182157e-01 0.927 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.261114e-01 0.899 0 0
Erythropoietin activates RAS R-HSA-9027284 2.870173e-01 0.542 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.870173e-01 0.542 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.870173e-01 0.542 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.870173e-01 0.542 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.870173e-01 0.542 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.870173e-01 0.542 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.426008e-01 0.846 0 0
HIV Transcription Initiation R-HSA-167161 1.426008e-01 0.846 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.426008e-01 0.846 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.282627e-01 0.368 0 0
Glycoprotein hormones R-HSA-209822 4.282627e-01 0.368 0 0
SOS-mediated signalling R-HSA-112412 4.282627e-01 0.368 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.599666e-01 0.796 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.374348e-01 0.862 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.513368e-01 0.600 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.447985e-01 0.839 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.781384e-01 0.749 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.523383e-01 0.817 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.523383e-01 0.817 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.217956e-01 0.654 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.217956e-01 0.654 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.875032e-01 0.727 0 0
Type I hemidesmosome assembly R-HSA-446107 4.593604e-01 0.338 0 0
phospho-PLA2 pathway R-HSA-111995 4.593604e-01 0.338 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.593604e-01 0.338 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.593604e-01 0.338 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.593604e-01 0.338 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.680947e-01 0.434 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.009571e-01 0.697 0 0
Signaling by Erythropoietin R-HSA-9006335 3.114455e-01 0.507 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.114455e-01 0.507 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.469750e-01 0.607 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.469750e-01 0.607 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.878493e-01 0.411 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.887684e-01 0.311 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.887684e-01 0.311 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.573393e-01 0.589 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.573393e-01 0.589 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.073259e-01 0.390 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.165784e-01 0.287 0 0
mRNA Splicing R-HSA-72172 1.303704e-01 0.885 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.568233e-01 0.448 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.568233e-01 0.448 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.568233e-01 0.448 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.018040e-01 0.396 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.018040e-01 0.396 0 0
Dual Incision in GG-NER R-HSA-5696400 4.018040e-01 0.396 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.207984e-01 0.494 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.638258e-01 0.334 0 0
Notch-HLH transcription pathway R-HSA-350054 4.638258e-01 0.334 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.428772e-01 0.265 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.819463e-01 0.317 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.819463e-01 0.317 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.458336e-01 0.351 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.315760e-01 0.365 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.170257e-01 0.286 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.023863e-01 0.299 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.339632e-01 0.272 0 0
MAP2K and MAPK activation R-HSA-5674135 5.160611e-01 0.287 0 0
Dual incision in TC-NER R-HSA-6782135 5.037928e-01 0.298 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.504888e-01 0.259 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.504888e-01 0.259 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.504888e-01 0.259 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.504888e-01 0.259 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.269710e-01 0.278 0 0
Transcription of the HIV genome R-HSA-167172 2.543808e-01 0.595 0 0
RNA Polymerase III Transcription R-HSA-74158 2.217956e-01 0.654 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.657262e-01 0.781 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.875032e-01 0.727 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.342424e-01 0.872 0 0
Nucleotide Excision Repair R-HSA-5696398 2.124599e-01 0.673 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.669191e-01 0.574 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.114455e-01 0.507 0 0
Activation of the pre-replicative complex R-HSA-68962 3.265880e-01 0.486 0 0
DNA Damage Bypass R-HSA-73893 2.165961e-01 0.664 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.444292e-01 0.352 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.730020e-01 0.564 0 0
DNA strand elongation R-HSA-69190 1.656859e-01 0.781 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.812462e-01 0.551 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.265880e-01 0.486 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.160611e-01 0.287 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.448561e-01 0.839 0 0
RET signaling R-HSA-8853659 2.217956e-01 0.654 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.996836e-01 0.301 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.933209e-01 0.714 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.050282e-01 0.688 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.394389e-01 0.856 0 0
CRMPs in Sema3A signaling R-HSA-399956 2.664583e-01 0.574 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.075214e-01 0.683 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.480191e-01 0.830 0 0
Peptide hormone biosynthesis R-HSA-209952 5.165784e-01 0.287 0 0
PI3K/AKT activation R-HSA-198203 5.165784e-01 0.287 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.047613e-01 0.297 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.311150e-01 0.882 0 0
RNA Polymerase I Transcription R-HSA-73864 5.253270e-01 0.280 0 0
Signaling by RAS mutants R-HSA-6802949 3.568233e-01 0.448 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.301130e-01 0.886 0 0
Gap junction degradation R-HSA-190873 1.456386e-01 0.837 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.849507e-01 0.545 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.606049e-01 0.443 0 0
mTORC1-mediated signalling R-HSA-166208 2.075214e-01 0.683 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.075214e-01 0.683 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.282627e-01 0.368 0 0
TGFBR3 expression R-HSA-9839394 2.513368e-01 0.600 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.812462e-01 0.551 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.593604e-01 0.338 0 0
Translesion Synthesis by POLH R-HSA-110320 3.878493e-01 0.411 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.878493e-01 0.411 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.887684e-01 0.311 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.018040e-01 0.396 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.057919e-01 0.687 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.057919e-01 0.687 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.399506e-01 0.620 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.824334e-01 0.549 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.166069e-01 0.380 0 0
DNA Double Strand Break Response R-HSA-5693606 1.311150e-01 0.882 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.602282e-01 0.337 0 0
MTOR signalling R-HSA-165159 1.511784e-01 0.821 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.528382e-01 0.597 0 0
Formation of the posterior neural plate R-HSA-9832991 1.848843e-01 0.733 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.238339e-01 0.490 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.050282e-01 0.688 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.606049e-01 0.443 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.067701e-01 0.513 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.255490e-01 0.647 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.264965e-01 0.370 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.428772e-01 0.265 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.943780e-01 0.404 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 1.842247e-01 0.735 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.170257e-01 0.286 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.160611e-01 0.287 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.280022e-01 0.893 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.114455e-01 0.507 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.365614e-01 0.626 0 0
Neurodegenerative Diseases R-HSA-8863678 2.365614e-01 0.626 0 0
Adipogenesis R-HSA-9843745 4.376922e-01 0.359 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.339632e-01 0.272 1 1
DNA Replication R-HSA-69306 1.673187e-01 0.776 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.953784e-01 0.403 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.365614e-01 0.626 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.278860e-01 0.484 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.868963e-01 0.412 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.428772e-01 0.265 0 0
Signaling by ERBB2 R-HSA-1227986 5.269710e-01 0.278 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.812462e-01 0.551 0 0
Oncogene Induced Senescence R-HSA-2559585 2.101793e-01 0.677 1 1
Chromosome Maintenance R-HSA-73886 1.407673e-01 0.851 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.783635e-01 0.555 0 0
Interleukin-6 family signaling R-HSA-6783589 2.365614e-01 0.626 0 0
Co-inhibition by PD-1 R-HSA-389948 2.489716e-01 0.604 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.448561e-01 0.839 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.887684e-01 0.311 0 0
TNF signaling R-HSA-75893 2.890030e-01 0.539 0 0
Interleukin-27 signaling R-HSA-9020956 1.650537e-01 0.782 0 0
DNA Repair R-HSA-73894 1.732162e-01 0.761 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.220627e-01 0.913 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 2.003560e-01 0.698 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.438341e-01 0.613 0 0
MET interacts with TNS proteins R-HSA-8875513 2.438341e-01 0.613 0 0
Formation of annular gap junctions R-HSA-196025 1.267521e-01 0.897 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.456386e-01 0.837 0 0
Alanine metabolism R-HSA-8964540 2.849507e-01 0.545 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.050282e-01 0.688 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.050282e-01 0.688 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.394389e-01 0.856 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 3.606049e-01 0.443 0 0
Sensory perception of salty taste R-HSA-9730628 3.606049e-01 0.443 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.606049e-01 0.443 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.458943e-01 0.609 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.953784e-01 0.403 0 0
Budding and maturation of HIV virion R-HSA-162588 1.551392e-01 0.809 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.282627e-01 0.368 0 0
DAG1 core M1 glycosylations R-HSA-8932506 4.282627e-01 0.368 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.282627e-01 0.368 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.781384e-01 0.749 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.114455e-01 0.507 0 0
Unwinding of DNA R-HSA-176974 4.887684e-01 0.311 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.863249e-01 0.730 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.165784e-01 0.287 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.165784e-01 0.287 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.018040e-01 0.396 0 0
vRNA Synthesis R-HSA-192814 5.428772e-01 0.265 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.635253e-01 0.439 0 0
MET promotes cell motility R-HSA-8875878 4.602282e-01 0.337 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 5.170257e-01 0.286 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.383610e-01 0.269 0 0
HCMV Early Events R-HSA-9609690 5.410573e-01 0.267 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.758045e-01 0.323 0 0
Cellular response to heat stress R-HSA-3371556 1.407673e-01 0.851 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.664583e-01 0.574 0 0
Aggrephagy R-HSA-9646399 4.885159e-01 0.311 0 0
Signaling by FGFR4 R-HSA-5654743 5.427901e-01 0.265 0 0
Interleukin-35 Signalling R-HSA-8984722 2.253926e-01 0.647 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.793777e-01 0.746 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.600489e-01 0.796 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.996836e-01 0.301 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.255490e-01 0.647 0 0
Gene Silencing by RNA R-HSA-211000 2.260474e-01 0.646 0 0
Signaling by WNT R-HSA-195721 2.496721e-01 0.603 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 1.268745e-01 0.897 0 0
IRS-mediated signalling R-HSA-112399 4.920174e-01 0.308 0 0
Signaling by EGFR R-HSA-177929 1.523383e-01 0.817 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.568233e-01 0.448 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.238339e-01 0.490 0 0
Rap1 signalling R-HSA-392517 3.878493e-01 0.411 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.073259e-01 0.390 0 0
Signal attenuation R-HSA-74749 5.165784e-01 0.287 0 0
Long-term potentiation R-HSA-9620244 5.170257e-01 0.286 0 0
MAPK family signaling cascades R-HSA-5683057 1.842501e-01 0.735 0 0
Negative regulation of MET activity R-HSA-6807004 1.657262e-01 0.781 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.638258e-01 0.334 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.456386e-01 0.837 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.268745e-01 0.897 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.606049e-01 0.443 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.606049e-01 0.443 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.075214e-01 0.683 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.870173e-01 0.542 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.480946e-01 0.458 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.593604e-01 0.338 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.719014e-01 0.430 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.165784e-01 0.287 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.919357e-01 0.535 0 0
Ub-specific processing proteases R-HSA-5689880 5.081607e-01 0.294 0 0
MHC class II antigen presentation R-HSA-2132295 1.506776e-01 0.822 0 0
Signaling by ERBB4 R-HSA-1236394 3.111252e-01 0.507 0 0
Collagen degradation R-HSA-1442490 3.430772e-01 0.465 0 0
Hormone ligand-binding receptors R-HSA-375281 5.428772e-01 0.265 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.315760e-01 0.365 0 0
Signaling by MET R-HSA-6806834 2.255490e-01 0.647 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.893384e-01 0.410 1 1
Cellular responses to stress R-HSA-2262752 4.689166e-01 0.329 1 0
Mismatch Repair R-HSA-5358508 1.394389e-01 0.856 0 0
Generic Transcription Pathway R-HSA-212436 1.960357e-01 0.708 1 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.018847e-01 0.695 0 0
Protein ubiquitination R-HSA-8852135 4.943476e-01 0.306 0 0
SLC-mediated bile acid transport R-HSA-9958517 1.267521e-01 0.897 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.147440e-01 0.940 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.238339e-01 0.490 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.793777e-01 0.746 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.953784e-01 0.403 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.764799e-01 0.753 0 0
VLDL clearance R-HSA-8964046 4.282627e-01 0.368 0 0
DAG1 core M2 glycosylations R-HSA-8932504 4.593604e-01 0.338 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.593604e-01 0.338 0 0
Late endosomal microautophagy R-HSA-9615710 3.114455e-01 0.507 0 0
ARMS-mediated activation R-HSA-170984 4.887684e-01 0.311 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.887684e-01 0.311 0 0
Host Interactions of HIV factors R-HSA-162909 1.557642e-01 0.808 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.264965e-01 0.370 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.165784e-01 0.287 0 0
2-LTR circle formation R-HSA-164843 5.165784e-01 0.287 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.430772e-01 0.465 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.428772e-01 0.265 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.171828e-01 0.499 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.996836e-01 0.301 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.732850e-01 0.325 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.504888e-01 0.259 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.265880e-01 0.486 0 0
HCMV Infection R-HSA-9609646 5.445131e-01 0.264 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.027719e-01 0.395 1 0
Base Excision Repair R-HSA-73884 3.189493e-01 0.496 0 0
Signal Transduction R-HSA-162582 2.185789e-01 0.660 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.504888e-01 0.259 0 0
Signaling by TGFBR3 R-HSA-9839373 3.568233e-01 0.448 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.456386e-01 0.837 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.606049e-01 0.443 0 0
Pyrimidine salvage R-HSA-73614 2.963232e-01 0.528 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.819463e-01 0.317 0 0
Deubiquitination R-HSA-5688426 3.712378e-01 0.430 0 0
HDMs demethylate histones R-HSA-3214842 5.170257e-01 0.286 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.317354e-01 0.274 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.849871e-01 0.314 0 0
tRNA processing in the nucleus R-HSA-6784531 2.009571e-01 0.697 0 0
ERK/MAPK targets R-HSA-198753 4.264965e-01 0.370 0 0
Kinesins R-HSA-983189 3.321778e-01 0.479 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.264965e-01 0.370 0 0
Cell junction organization R-HSA-446728 4.025118e-01 0.395 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.995213e-01 0.398 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.719014e-01 0.430 0 0
Signaling by NOTCH2 R-HSA-1980145 4.018040e-01 0.396 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.516426e-01 0.345 0 0
Regulation of beta-cell development R-HSA-186712 1.759592e-01 0.755 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.096058e-01 0.388 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.261114e-01 0.899 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.812462e-01 0.551 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.568380e-01 0.448 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.540001e-01 0.451 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 2.849507e-01 0.545 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.238339e-01 0.490 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.238339e-01 0.490 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.253926e-01 0.647 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.870173e-01 0.542 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.342424e-01 0.872 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.764799e-01 0.753 0 0
Regulation of PTEN localization R-HSA-8948747 4.282627e-01 0.368 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.282627e-01 0.368 0 0
Sodium/Proton exchangers R-HSA-425986 4.593604e-01 0.338 0 0
DAG1 core M3 glycosylations R-HSA-8932505 5.428772e-01 0.265 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.339632e-01 0.272 0 0
Adherens junctions interactions R-HSA-418990 3.554619e-01 0.449 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.194935e-01 0.496 0 0
Autophagy R-HSA-9612973 3.823979e-01 0.417 0 0
Regulation of TP53 Activity R-HSA-5633007 1.305880e-01 0.884 0 0
Cell-cell junction organization R-HSA-421270 5.502386e-01 0.259 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.814367e-01 0.551 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.814367e-01 0.551 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.656859e-01 0.781 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.170257e-01 0.286 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.647957e-01 0.783 0 0
Inositol phosphate metabolism R-HSA-1483249 1.617194e-01 0.791 0 0
RUNX2 regulates bone development R-HSA-8941326 4.312884e-01 0.365 0 0
Signaling by NOTCH3 R-HSA-9012852 2.783635e-01 0.555 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.650537e-01 0.782 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.887684e-01 0.311 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.730020e-01 0.564 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.321778e-01 0.479 0 0
Myogenesis R-HSA-525793 5.339632e-01 0.272 0 0
TBC/RABGAPs R-HSA-8854214 5.427901e-01 0.265 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.268745e-01 0.897 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 3.606049e-01 0.443 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.664583e-01 0.574 0 0
HDL clearance R-HSA-8964011 3.953784e-01 0.403 0 0
Formation of the anterior neural plate R-HSA-9823739 2.870173e-01 0.542 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.875032e-01 0.727 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.887684e-01 0.311 0 0
Lipophagy R-HSA-9613354 4.887684e-01 0.311 0 0
Chylomicron assembly R-HSA-8963888 5.428772e-01 0.265 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.428772e-01 0.265 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.090035e-01 0.680 0 0
MAP kinase activation R-HSA-450294 5.383610e-01 0.269 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.133983e-01 0.945 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.664583e-01 0.574 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.182157e-01 0.927 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.219458e-01 0.654 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.075110e-01 0.512 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.680947e-01 0.434 0 0
Josephin domain DUBs R-HSA-5689877 5.165784e-01 0.287 0 0
Azathioprine ADME R-HSA-9748787 4.068320e-01 0.391 0 0
PI3K Cascade R-HSA-109704 4.068320e-01 0.391 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.819463e-01 0.317 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.192411e-01 0.496 0 0
Apoptosis R-HSA-109581 4.245372e-01 0.372 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.453367e-01 0.351 0 0
TNFs bind their physiological receptors R-HSA-5669034 4.996836e-01 0.301 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.370952e-01 0.625 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.606049e-01 0.443 0 0
PECAM1 interactions R-HSA-210990 5.428772e-01 0.265 0 0
Glutathione conjugation R-HSA-156590 5.269710e-01 0.278 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.593697e-01 0.586 0 0
Mitochondrial biogenesis R-HSA-1592230 2.027982e-01 0.693 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.238339e-01 0.490 0 0
Assembly Of The HIV Virion R-HSA-175474 1.933209e-01 0.714 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.282627e-01 0.368 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 4.887684e-01 0.311 0 0
Maturation of spike protein R-HSA-9683686 5.165784e-01 0.287 0 0
Signaling by ALK R-HSA-201556 2.575591e-01 0.589 0 0
Interleukin-7 signaling R-HSA-1266695 2.513368e-01 0.600 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.354691e-01 0.271 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.887684e-01 0.311 0 0
Signaling by Leptin R-HSA-2586552 5.165784e-01 0.287 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.458943e-01 0.609 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.301130e-01 0.886 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 3.480946e-01 0.458 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.744596e-01 0.324 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.496107e-01 0.260 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 4.996836e-01 0.301 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 5.504888e-01 0.259 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.504888e-01 0.259 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 2.664583e-01 0.574 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 3.878493e-01 0.411 0 0
Growth hormone receptor signaling R-HSA-982772 4.819463e-01 0.317 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 3.238339e-01 0.490 0 0
Nephron development R-HSA-9831926 3.680947e-01 0.434 0 0
Triglyceride catabolism R-HSA-163560 4.312884e-01 0.365 0 0
Insulin processing R-HSA-264876 5.504888e-01 0.259 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.018040e-01 0.396 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.037928e-01 0.298 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.295317e-01 0.276 0 0
Maturation of hRSV A proteins R-HSA-9828806 2.812462e-01 0.551 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.744596e-01 0.324 0 0
RMTs methylate histone arginines R-HSA-3214858 5.558294e-01 0.255 0 0
Netrin-1 signaling R-HSA-373752 5.558294e-01 0.255 0 0
Semaphorin interactions R-HSA-373755 5.607149e-01 0.251 0 0
Signaling by PTK6 R-HSA-8848021 5.607149e-01 0.251 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.607149e-01 0.251 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.607149e-01 0.251 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.665972e-01 0.247 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.665972e-01 0.247 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.665972e-01 0.247 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.677468e-01 0.246 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.677468e-01 0.246 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.677468e-01 0.246 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.677468e-01 0.246 0 0
Integration of provirus R-HSA-162592 5.677468e-01 0.246 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.677468e-01 0.246 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.677468e-01 0.246 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.677468e-01 0.246 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.677468e-01 0.246 0 0
Activation of RAC1 R-HSA-428540 5.677468e-01 0.246 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 5.677468e-01 0.246 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.677468e-01 0.246 0 0
Signaling by FGFR3 R-HSA-5654741 5.686435e-01 0.245 0 0
Insulin receptor signalling cascade R-HSA-74751 5.716686e-01 0.243 0 0
IGF1R signaling cascade R-HSA-2428924 5.716686e-01 0.243 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.736368e-01 0.241 0 0
ESR-mediated signaling R-HSA-8939211 5.746882e-01 0.241 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.749971e-01 0.240 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.812272e-01 0.236 0 0
Diseases of DNA repair R-HSA-9675135 5.812272e-01 0.236 0 0
DNA methylation R-HSA-5334118 5.822849e-01 0.235 0 0
mRNA Capping R-HSA-72086 5.822849e-01 0.235 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.822849e-01 0.235 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 5.822849e-01 0.235 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.822849e-01 0.235 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.822849e-01 0.235 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.822849e-01 0.235 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.822849e-01 0.235 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.824677e-01 0.235 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.824677e-01 0.235 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.845997e-01 0.233 0 0
Glycolysis R-HSA-70171 5.871224e-01 0.231 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.912648e-01 0.228 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.912648e-01 0.228 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.912648e-01 0.228 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.912648e-01 0.228 0 0
OAS antiviral response R-HSA-8983711 5.912648e-01 0.228 0 0
Recycling pathway of L1 R-HSA-437239 5.935759e-01 0.227 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.975499e-01 0.224 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.975499e-01 0.224 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.975499e-01 0.224 0 0
Activation of BH3-only proteins R-HSA-114452 5.975499e-01 0.224 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.023767e-01 0.220 0 0
Programmed Cell Death R-HSA-5357801 6.035807e-01 0.219 0 0
Cell-Cell communication R-HSA-1500931 6.040136e-01 0.219 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.042941e-01 0.219 1 1
EGFR downregulation R-HSA-182971 6.123918e-01 0.213 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.135032e-01 0.212 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.135046e-01 0.212 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.135046e-01 0.212 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.135046e-01 0.212 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.135046e-01 0.212 0 0
Chylomicron remodeling R-HSA-8963901 6.135046e-01 0.212 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.135046e-01 0.212 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.135046e-01 0.212 0 0
Maturation of nucleoprotein R-HSA-9683610 6.135046e-01 0.212 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.135046e-01 0.212 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.138995e-01 0.212 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.175537e-01 0.209 0 0
Cellular responses to stimuli R-HSA-8953897 6.281020e-01 0.202 1 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.288756e-01 0.201 0 0
Diseases of programmed cell death R-HSA-9645723 6.307797e-01 0.200 0 0
Interleukin-17 signaling R-HSA-448424 6.340190e-01 0.198 0 0
Removal of the Flap Intermediate R-HSA-69166 6.345356e-01 0.198 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 6.345356e-01 0.198 0 0
Hydrolysis of LPC R-HSA-1483115 6.345356e-01 0.198 0 0
cGMP effects R-HSA-418457 6.345356e-01 0.198 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.345356e-01 0.198 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.345356e-01 0.198 0 0
P2Y receptors R-HSA-417957 6.345356e-01 0.198 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.405544e-01 0.193 0 0
HSF1-dependent transactivation R-HSA-3371571 6.405544e-01 0.193 0 0
Meiotic recombination R-HSA-912446 6.405544e-01 0.193 0 0
Integrin signaling R-HSA-354192 6.408110e-01 0.193 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.408110e-01 0.193 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.408110e-01 0.193 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.408110e-01 0.193 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.408110e-01 0.193 0 0
Recycling of bile acids and salts R-HSA-159418 6.408110e-01 0.193 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.434244e-01 0.192 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.438209e-01 0.191 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.438209e-01 0.191 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.438991e-01 0.191 0 0
Orc1 removal from chromatin R-HSA-68949 6.516839e-01 0.186 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.516839e-01 0.186 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.516839e-01 0.186 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.516839e-01 0.186 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.534486e-01 0.185 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.543932e-01 0.184 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.544234e-01 0.184 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.544234e-01 0.184 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.544234e-01 0.184 0 0
p38MAPK events R-HSA-171007 6.544234e-01 0.184 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.544234e-01 0.184 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.544234e-01 0.184 0 0
Protein methylation R-HSA-8876725 6.544234e-01 0.184 0 0
Macroautophagy R-HSA-1632852 6.569972e-01 0.182 0 0
Stimuli-sensing channels R-HSA-2672351 6.611777e-01 0.180 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.625650e-01 0.179 0 0
Meiotic synapsis R-HSA-1221632 6.625650e-01 0.179 0 0
Ca2+ pathway R-HSA-4086398 6.629006e-01 0.179 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.675621e-01 0.176 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.675621e-01 0.176 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.675621e-01 0.176 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.675621e-01 0.176 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.675621e-01 0.176 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.704690e-01 0.174 0 0
Signaling by NOTCH4 R-HSA-9013694 6.721757e-01 0.173 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.731974e-01 0.172 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.732300e-01 0.172 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.732300e-01 0.172 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.732300e-01 0.172 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.732300e-01 0.172 0 0
Activation of SMO R-HSA-5635838 6.732300e-01 0.172 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.732300e-01 0.172 0 0
Mineralocorticoid biosynthesis R-HSA-193993 6.732300e-01 0.172 0 0
Attachment and Entry R-HSA-9678110 6.732300e-01 0.172 0 0
Virus Assembly and Release R-HSA-168268 6.732300e-01 0.172 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.770836e-01 0.169 0 0
Membrane Trafficking R-HSA-199991 6.783227e-01 0.169 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.803225e-01 0.167 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.803225e-01 0.167 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.803225e-01 0.167 0 0
HDACs deacetylate histones R-HSA-3214815 6.835811e-01 0.165 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.910143e-01 0.161 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.910143e-01 0.161 0 0
Synthesis of PG R-HSA-1483148 6.910143e-01 0.161 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.910143e-01 0.161 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.910143e-01 0.161 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.912846e-01 0.160 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.912846e-01 0.160 0 0
HSF1 activation R-HSA-3371511 6.926798e-01 0.159 0 0
Signaling by FGFR1 R-HSA-5654736 6.937168e-01 0.159 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.937168e-01 0.159 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.985280e-01 0.156 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.003040e-01 0.155 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.046401e-01 0.152 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 7.046401e-01 0.152 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.046401e-01 0.152 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.078317e-01 0.150 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.078317e-01 0.150 0 0
Sulfide oxidation to sulfate R-HSA-1614517 7.078317e-01 0.150 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.078317e-01 0.150 0 0
Signaling by Hippo R-HSA-2028269 7.078317e-01 0.150 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.078317e-01 0.150 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.078317e-01 0.150 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.078317e-01 0.150 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.078317e-01 0.150 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.078317e-01 0.150 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.089128e-01 0.149 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.131809e-01 0.147 0 0
Telomere Maintenance R-HSA-157579 7.206581e-01 0.142 0 0
Extension of Telomeres R-HSA-180786 7.226476e-01 0.141 0 0
Triglyceride metabolism R-HSA-8979227 7.226476e-01 0.141 0 0
GAB1 signalosome R-HSA-180292 7.237347e-01 0.140 0 0
PKA activation in glucagon signalling R-HSA-164378 7.237347e-01 0.140 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.237347e-01 0.140 0 0
PKA activation R-HSA-163615 7.237347e-01 0.140 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.237347e-01 0.140 0 0
Apoptotic factor-mediated response R-HSA-111471 7.237347e-01 0.140 0 0
Platelet sensitization by LDL R-HSA-432142 7.237347e-01 0.140 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.237347e-01 0.140 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.237347e-01 0.140 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.237347e-01 0.140 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.273964e-01 0.138 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.273964e-01 0.138 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.279951e-01 0.138 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.279951e-01 0.138 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.279951e-01 0.138 0 0
tRNA processing R-HSA-72306 7.284250e-01 0.138 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.306411e-01 0.136 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.318046e-01 0.136 0 0
L1CAM interactions R-HSA-373760 7.330186e-01 0.135 0 0
FOXO-mediated transcription R-HSA-9614085 7.351922e-01 0.134 0 0
Toll-like Receptor Cascades R-HSA-168898 7.355440e-01 0.133 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.382070e-01 0.132 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.382070e-01 0.132 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.382070e-01 0.132 0 0
HIV Transcription Elongation R-HSA-167169 7.382070e-01 0.132 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.382070e-01 0.132 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.382070e-01 0.132 0 0
Attenuation phase R-HSA-3371568 7.382070e-01 0.132 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.382070e-01 0.132 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.382070e-01 0.132 0 0
Interleukin-2 family signaling R-HSA-451927 7.382070e-01 0.132 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.387730e-01 0.131 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.387730e-01 0.131 0 0
Regulation of signaling by CBL R-HSA-912631 7.387730e-01 0.131 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.387730e-01 0.131 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.387730e-01 0.131 0 0
HDL remodeling R-HSA-8964058 7.387730e-01 0.131 0 0
Maturation of nucleoprotein R-HSA-9694631 7.387730e-01 0.131 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.387730e-01 0.131 0 0
Other interleukin signaling R-HSA-449836 7.387730e-01 0.131 0 0
Glucose metabolism R-HSA-70326 7.395699e-01 0.131 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.407219e-01 0.130 0 0
Nucleotide salvage R-HSA-8956321 7.407219e-01 0.130 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.486494e-01 0.126 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.486494e-01 0.126 0 0
PPARA activates gene expression R-HSA-1989781 7.499032e-01 0.125 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.499032e-01 0.125 0 0
Adaptive Immune System R-HSA-1280218 7.510803e-01 0.124 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.529936e-01 0.123 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.529936e-01 0.123 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.529936e-01 0.123 0 0
Acyl chain remodelling of PI R-HSA-1482922 7.529936e-01 0.123 0 0
Formation of definitive endoderm R-HSA-9823730 7.529936e-01 0.123 0 0
Signal transduction by L1 R-HSA-445144 7.529936e-01 0.123 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.553431e-01 0.122 0 0
PI Metabolism R-HSA-1483255 7.559472e-01 0.122 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.563492e-01 0.121 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.587316e-01 0.120 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.587316e-01 0.120 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.587316e-01 0.120 0 0
Translation of Structural Proteins R-HSA-9683701 7.587316e-01 0.120 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.608396e-01 0.119 0 0
HCMV Late Events R-HSA-9610379 7.608396e-01 0.119 0 0
Signaling by Hedgehog R-HSA-5358351 7.620836e-01 0.118 0 0
Meiosis R-HSA-1500620 7.624719e-01 0.118 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.664408e-01 0.116 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.664408e-01 0.116 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.664408e-01 0.116 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.664408e-01 0.116 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.664408e-01 0.116 0 0
Signalling to RAS R-HSA-167044 7.664408e-01 0.116 0 0
Acyl chain remodelling of PG R-HSA-1482925 7.664408e-01 0.116 0 0
Basigin interactions R-HSA-210991 7.664408e-01 0.116 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 7.664408e-01 0.116 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.674875e-01 0.115 0 0
Activation of GABAB receptors R-HSA-991365 7.684620e-01 0.114 0 0
GABA B receptor activation R-HSA-977444 7.684620e-01 0.114 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.684620e-01 0.114 0 0
Ca-dependent events R-HSA-111996 7.684620e-01 0.114 0 0
Depyrimidination R-HSA-73928 7.684620e-01 0.114 0 0
Axon guidance R-HSA-422475 7.691391e-01 0.114 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.696288e-01 0.114 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.714639e-01 0.113 0 0
Cellular response to hypoxia R-HSA-1234174 7.740484e-01 0.111 0 0
Influenza Infection R-HSA-168255 7.754986e-01 0.110 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.766156e-01 0.110 0 0
Defective pyroptosis R-HSA-9710421 7.778489e-01 0.109 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.791567e-01 0.108 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.791567e-01 0.108 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.791567e-01 0.108 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.791567e-01 0.108 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.791567e-01 0.108 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.791567e-01 0.108 0 0
Glutathione synthesis and recycling R-HSA-174403 7.791567e-01 0.108 0 0
Androgen biosynthesis R-HSA-193048 7.791567e-01 0.108 0 0
Attachment and Entry R-HSA-9694614 7.791567e-01 0.108 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.791567e-01 0.108 0 0
Interleukin-12 family signaling R-HSA-447115 7.834341e-01 0.106 0 0
Signaling by NOTCH R-HSA-157118 7.843739e-01 0.105 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.869008e-01 0.104 0 0
Gap junction trafficking R-HSA-190828 7.869008e-01 0.104 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 7.893498e-01 0.103 0 0
Kidney development R-HSA-9830369 7.893498e-01 0.103 0 0
Selective autophagy R-HSA-9663891 7.900860e-01 0.102 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.911811e-01 0.102 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 7.911811e-01 0.102 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.911811e-01 0.102 0 0
LDL clearance R-HSA-8964038 7.911811e-01 0.102 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.911811e-01 0.102 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.956265e-01 0.099 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.956265e-01 0.099 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.956265e-01 0.099 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.956265e-01 0.099 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 7.956265e-01 0.099 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.956265e-01 0.099 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.995880e-01 0.097 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.025514e-01 0.096 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.025514e-01 0.096 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.025514e-01 0.096 0 0
Carnitine shuttle R-HSA-200425 8.025514e-01 0.096 0 0
Formation of the ureteric bud R-HSA-9830674 8.025514e-01 0.096 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.028983e-01 0.095 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.040345e-01 0.095 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.052900e-01 0.094 0 0
Interferon Signaling R-HSA-913531 8.056696e-01 0.094 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.106788e-01 0.091 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.121336e-01 0.090 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.121336e-01 0.090 0 0
Synthesis of PC R-HSA-1483191 8.121336e-01 0.090 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.133033e-01 0.090 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.133033e-01 0.090 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.133033e-01 0.090 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.133033e-01 0.090 0 0
Cellular response to chemical stress R-HSA-9711123 8.155582e-01 0.089 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.169691e-01 0.088 0 0
Hedgehog 'on' state R-HSA-5632684 8.173710e-01 0.088 0 0
Nervous system development R-HSA-9675108 8.184534e-01 0.087 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.188973e-01 0.087 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.197038e-01 0.086 0 0
Plasma lipoprotein remodeling R-HSA-8963899 8.199325e-01 0.086 0 0
Metal ion SLC transporters R-HSA-425410 8.199325e-01 0.086 0 0
Signaling by Insulin receptor R-HSA-74752 8.209197e-01 0.086 0 0
EPH-Ephrin signaling R-HSA-2682334 8.209197e-01 0.086 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.209197e-01 0.086 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.234703e-01 0.084 0 0
G protein gated Potassium channels R-HSA-1296059 8.234703e-01 0.084 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.234703e-01 0.084 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.234703e-01 0.084 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.234703e-01 0.084 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.234703e-01 0.084 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 8.234703e-01 0.084 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.234703e-01 0.084 0 0
Cilium Assembly R-HSA-5617833 8.246889e-01 0.084 0 0
Gap junction trafficking and regulation R-HSA-157858 8.274399e-01 0.082 0 0
Degradation of CDH1 R-HSA-9766229 8.274399e-01 0.082 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.330842e-01 0.079 0 0
Metalloprotease DUBs R-HSA-5689901 8.330842e-01 0.079 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.330842e-01 0.079 0 0
Urea cycle R-HSA-70635 8.330842e-01 0.079 0 0
Sphingolipid catabolism R-HSA-9845614 8.330842e-01 0.079 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.330842e-01 0.079 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.330842e-01 0.079 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.346643e-01 0.078 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.416142e-01 0.075 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.421751e-01 0.075 0 0
Packaging Of Telomere Ends R-HSA-171306 8.421751e-01 0.075 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.421751e-01 0.075 0 0
Cristae formation R-HSA-8949613 8.421751e-01 0.075 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.421751e-01 0.075 0 0
Signaling by BMP R-HSA-201451 8.421751e-01 0.075 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.421751e-01 0.075 0 0
UCH proteinases R-HSA-5689603 8.478834e-01 0.072 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.479193e-01 0.072 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.507714e-01 0.070 0 0
HIV elongation arrest and recovery R-HSA-167287 8.507714e-01 0.070 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.507714e-01 0.070 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.507714e-01 0.070 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.507714e-01 0.070 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.507714e-01 0.070 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.507714e-01 0.070 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.547246e-01 0.068 0 0
Nucleotide biosynthesis R-HSA-8956320 8.547246e-01 0.068 0 0
Smooth Muscle Contraction R-HSA-445355 8.547246e-01 0.068 0 0
Rab regulation of trafficking R-HSA-9007101 8.554518e-01 0.068 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.554607e-01 0.068 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.580242e-01 0.067 0 0
Thyroxine biosynthesis R-HSA-209968 8.589000e-01 0.066 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.589000e-01 0.066 0 0
Platelet calcium homeostasis R-HSA-418360 8.589000e-01 0.066 0 0
DARPP-32 events R-HSA-180024 8.589000e-01 0.066 0 0
Translation initiation complex formation R-HSA-72649 8.609016e-01 0.065 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.609016e-01 0.065 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.640746e-01 0.063 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.640746e-01 0.063 0 0
Neddylation R-HSA-8951664 8.649238e-01 0.063 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.665862e-01 0.062 0 0
Neurotransmitter clearance R-HSA-112311 8.665862e-01 0.062 0 0
Signaling by FGFR2 R-HSA-5654738 8.690055e-01 0.061 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.690055e-01 0.061 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.725395e-01 0.059 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.738542e-01 0.059 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.738542e-01 0.059 0 0
Cargo concentration in the ER R-HSA-5694530 8.738542e-01 0.059 0 0
Downstream signal transduction R-HSA-186763 8.738542e-01 0.059 0 0
Amyloid fiber formation R-HSA-977225 8.738645e-01 0.059 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.761954e-01 0.057 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.761954e-01 0.057 0 0
Synthesis of PA R-HSA-1483166 8.780162e-01 0.056 0 0
Regulation of CDH1 Function R-HSA-9764561 8.780162e-01 0.056 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.807267e-01 0.055 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.807267e-01 0.055 0 0
DAG1 glycosylations R-HSA-8931838 8.807267e-01 0.055 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.831057e-01 0.054 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.832750e-01 0.054 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.872251e-01 0.052 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.872251e-01 0.052 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.872251e-01 0.052 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.874962e-01 0.052 0 0
Peroxisomal protein import R-HSA-9033241 8.883233e-01 0.051 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.883233e-01 0.051 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.916840e-01 0.050 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.917387e-01 0.050 0 0
GABA receptor activation R-HSA-977443 8.931685e-01 0.049 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.931685e-01 0.049 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.933699e-01 0.049 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.933699e-01 0.049 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.933699e-01 0.049 0 0
Heme degradation R-HSA-189483 8.933699e-01 0.049 0 0
Ion channel transport R-HSA-983712 8.943199e-01 0.049 0 0
PLC beta mediated events R-HSA-112043 8.978177e-01 0.047 0 0
Aquaporin-mediated transport R-HSA-445717 8.978177e-01 0.047 0 0
Endogenous sterols R-HSA-211976 8.978177e-01 0.047 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.991802e-01 0.046 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.991802e-01 0.046 0 0
Signal amplification R-HSA-392518 8.991802e-01 0.046 0 0
Post NMDA receptor activation events R-HSA-438064 9.036184e-01 0.044 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.046742e-01 0.044 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.046742e-01 0.044 0 0
PERK regulates gene expression R-HSA-381042 9.046742e-01 0.044 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.065556e-01 0.043 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.091111e-01 0.041 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.091111e-01 0.041 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.098692e-01 0.041 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.098692e-01 0.041 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.098692e-01 0.041 0 0
FLT3 signaling in disease R-HSA-9682385 9.098692e-01 0.041 0 0
GPVI-mediated activation cascade R-HSA-114604 9.098692e-01 0.041 0 0
Calmodulin induced events R-HSA-111933 9.098692e-01 0.041 0 0
CaM pathway R-HSA-111997 9.098692e-01 0.041 0 0
Ion transport by P-type ATPases R-HSA-936837 9.106578e-01 0.041 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.126840e-01 0.040 0 0
Neurotransmitter release cycle R-HSA-112310 9.143077e-01 0.039 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.145908e-01 0.039 0 0
Degradation of AXIN R-HSA-4641257 9.147813e-01 0.039 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.147813e-01 0.039 0 0
Voltage gated Potassium channels R-HSA-1296072 9.147813e-01 0.039 0 0
Cleavage of the damaged purine R-HSA-110331 9.147813e-01 0.039 0 0
NCAM1 interactions R-HSA-419037 9.147813e-01 0.039 0 0
Collagen chain trimerization R-HSA-8948216 9.147813e-01 0.039 0 0
Metabolism of folate and pterines R-HSA-196757 9.147813e-01 0.039 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.158847e-01 0.038 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.176239e-01 0.037 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.176239e-01 0.037 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.183299e-01 0.037 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.183609e-01 0.037 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.183609e-01 0.037 0 0
Viral Infection Pathways R-HSA-9824446 9.192546e-01 0.037 0 0
Depurination R-HSA-73927 9.194261e-01 0.036 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.194261e-01 0.036 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.194261e-01 0.036 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.194261e-01 0.036 0 0
Purine salvage R-HSA-74217 9.194261e-01 0.036 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.194261e-01 0.036 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.194261e-01 0.036 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.208226e-01 0.036 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.212117e-01 0.036 0 0
G-protein mediated events R-HSA-112040 9.219740e-01 0.035 0 0
Stabilization of p53 R-HSA-69541 9.238179e-01 0.034 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 9.238179e-01 0.034 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.238179e-01 0.034 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.238179e-01 0.034 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.239074e-01 0.034 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.254361e-01 0.034 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.267031e-01 0.033 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.279706e-01 0.032 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.279706e-01 0.032 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.279706e-01 0.032 0 0
Signaling by ROBO receptors R-HSA-376176 9.282212e-01 0.032 0 0
Collagen formation R-HSA-1474290 9.297492e-01 0.032 0 0
Interferon gamma signaling R-HSA-877300 9.298129e-01 0.032 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.318972e-01 0.031 0 0
Maturation of spike protein R-HSA-9694548 9.318972e-01 0.031 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.319300e-01 0.031 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.319300e-01 0.031 0 0
Ribosome-associated quality control R-HSA-9948299 9.334556e-01 0.030 0 0
Peptide hormone metabolism R-HSA-2980736 9.342952e-01 0.030 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.351762e-01 0.029 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.356099e-01 0.029 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.356099e-01 0.029 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.356099e-01 0.029 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.356099e-01 0.029 0 0
Intra-Golgi traffic R-HSA-6811438 9.356099e-01 0.029 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.356099e-01 0.029 0 0
PTEN Regulation R-HSA-6807070 9.356783e-01 0.029 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.391204e-01 0.027 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.391204e-01 0.027 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.424398e-01 0.026 0 0
Pyrimidine catabolism R-HSA-73621 9.424398e-01 0.026 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.424398e-01 0.026 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.424398e-01 0.026 0 0
Signaling by SCF-KIT R-HSA-1433557 9.424398e-01 0.026 0 0
Signaling by FGFR R-HSA-190236 9.425947e-01 0.026 0 0
Signaling by FGFR in disease R-HSA-1226099 9.433457e-01 0.025 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.448873e-01 0.025 0 0
Methylation R-HSA-156581 9.455784e-01 0.024 0 0
Surfactant metabolism R-HSA-5683826 9.455784e-01 0.024 0 0
SLC transporter disorders R-HSA-5619102 9.456992e-01 0.024 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.459012e-01 0.024 0 0
Hedgehog 'off' state R-HSA-5610787 9.470945e-01 0.024 0 0
Interleukin-12 signaling R-HSA-9020591 9.483467e-01 0.023 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.485460e-01 0.023 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.485460e-01 0.023 0 0
DAG and IP3 signaling R-HSA-1489509 9.485460e-01 0.023 0 0
Translation of Structural Proteins R-HSA-9694635 9.506866e-01 0.022 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.512645e-01 0.022 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.513519e-01 0.022 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.513519e-01 0.022 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.523660e-01 0.021 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.528729e-01 0.021 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.529251e-01 0.021 0 0
PCP/CE pathway R-HSA-4086400 9.529251e-01 0.021 0 0
ABC transporter disorders R-HSA-5619084 9.529251e-01 0.021 0 0
Cholesterol biosynthesis R-HSA-191273 9.529251e-01 0.021 0 0
Interleukin-10 signaling R-HSA-6783783 9.529251e-01 0.021 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.529251e-01 0.021 0 0
Vesicle-mediated transport R-HSA-5653656 9.532732e-01 0.021 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.540050e-01 0.020 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.540050e-01 0.020 0 0
Opioid Signalling R-HSA-111885 9.551262e-01 0.020 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.551262e-01 0.020 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.551262e-01 0.020 0 0
Developmental Biology R-HSA-1266738 9.557916e-01 0.020 0 0
Gastrulation R-HSA-9758941 9.560752e-01 0.020 0 0
Co-stimulation by CD28 R-HSA-389356 9.565136e-01 0.019 0 0
GPER1 signaling R-HSA-9634597 9.565136e-01 0.019 0 0
Intraflagellar transport R-HSA-5620924 9.565136e-01 0.019 0 0
RSV-host interactions R-HSA-9833110 9.569479e-01 0.019 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.588855e-01 0.018 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.588855e-01 0.018 0 0
Platelet homeostasis R-HSA-418346 9.603854e-01 0.018 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.603854e-01 0.018 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.611281e-01 0.017 0 0
Reproduction R-HSA-1474165 9.625817e-01 0.017 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.635640e-01 0.016 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.635640e-01 0.016 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.644463e-01 0.016 0 0
Neurexins and neuroligins R-HSA-6794361 9.652535e-01 0.015 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.652535e-01 0.015 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.665013e-01 0.015 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.671491e-01 0.015 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.676449e-01 0.014 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.691385e-01 0.014 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.691385e-01 0.014 0 0
Pyruvate metabolism R-HSA-70268 9.705655e-01 0.013 0 0
G alpha (z) signalling events R-HSA-418597 9.706361e-01 0.013 0 0
Integration of energy metabolism R-HSA-163685 9.714699e-01 0.013 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.719288e-01 0.012 0 0
Peptide chain elongation R-HSA-156902 9.719288e-01 0.012 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.722384e-01 0.012 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.722384e-01 0.012 0 0
Ion homeostasis R-HSA-5578775 9.722384e-01 0.012 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.741147e-01 0.011 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.761600e-01 0.010 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.761600e-01 0.010 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.765399e-01 0.010 0 0
IRE1alpha activates chaperones R-HSA-381070 9.767974e-01 0.010 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.774911e-01 0.010 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.776277e-01 0.010 0 0
SARS-CoV Infections R-HSA-9679506 9.777444e-01 0.010 0 0
RAB geranylgeranylation R-HSA-8873719 9.778204e-01 0.010 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.778805e-01 0.010 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.790310e-01 0.009 0 0
Mitochondrial protein import R-HSA-1268020 9.801756e-01 0.009 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.801756e-01 0.009 0 0
Signaling by PDGF R-HSA-186797 9.801756e-01 0.009 0 0
Signaling by Interleukins R-HSA-449147 9.803637e-01 0.009 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.808443e-01 0.008 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.812578e-01 0.008 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.812578e-01 0.008 0 0
Complex I biogenesis R-HSA-6799198 9.812578e-01 0.008 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.812578e-01 0.008 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.817437e-01 0.008 0 0
Eukaryotic Translation Termination R-HSA-72764 9.817437e-01 0.008 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.818848e-01 0.008 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.822810e-01 0.008 0 0
Potassium Channels R-HSA-1296071 9.826022e-01 0.008 0 0
Regulation of insulin secretion R-HSA-422356 9.842030e-01 0.007 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.842273e-01 0.007 0 0
Metabolism of steroid hormones R-HSA-196071 9.850278e-01 0.007 0 0
Nicotinate metabolism R-HSA-196807 9.850278e-01 0.007 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.850278e-01 0.007 0 0
ABC-family proteins mediated transport R-HSA-382556 9.856603e-01 0.006 0 0
Platelet degranulation R-HSA-114608 9.858404e-01 0.006 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.858453e-01 0.006 0 0
Regulated Necrosis R-HSA-5218859 9.858453e-01 0.006 0 0
Protein localization R-HSA-9609507 9.860970e-01 0.006 0 0
Selenocysteine synthesis R-HSA-2408557 9.863390e-01 0.006 0 0
COPII-mediated vesicle transport R-HSA-204005 9.873491e-01 0.006 0 0
Viral mRNA Translation R-HSA-192823 9.876040e-01 0.005 0 0
Retinoid metabolism and transport R-HSA-975634 9.880401e-01 0.005 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.880401e-01 0.005 0 0
Metabolism of porphyrins R-HSA-189445 9.880401e-01 0.005 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.881929e-01 0.005 0 0
Cardiac conduction R-HSA-5576891 9.886426e-01 0.005 0 0
Cellular response to starvation R-HSA-9711097 9.886700e-01 0.005 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.886933e-01 0.005 0 0
Purine catabolism R-HSA-74259 9.886933e-01 0.005 0 0
Metabolism of nucleotides R-HSA-15869 9.887030e-01 0.005 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.893109e-01 0.005 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.896070e-01 0.005 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.902876e-01 0.004 0 0
Centrosome maturation R-HSA-380287 9.904468e-01 0.004 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.904468e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.915889e-01 0.004 0 0
Sensory processing of sound R-HSA-9659379 9.923697e-01 0.003 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.923697e-01 0.003 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.923988e-01 0.003 0 0
PKR-mediated signaling R-HSA-9833482 9.927867e-01 0.003 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.930530e-01 0.003 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.931809e-01 0.003 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.934457e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.940625e-01 0.003 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.940625e-01 0.003 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.944299e-01 0.002 0 0
rRNA processing R-HSA-72312 9.950217e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.951331e-01 0.002 0 0
Potential therapeutics for SARS R-HSA-9679191 9.955875e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.961134e-01 0.002 0 0
Downstream TCR signaling R-HSA-202424 9.961134e-01 0.002 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.963443e-01 0.002 0 0
Muscle contraction R-HSA-397014 9.963443e-01 0.002 0 0
Signaling by VEGF R-HSA-194138 9.965643e-01 0.001 0 0
Transmission across Chemical Synapses R-HSA-112315 9.967587e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.968701e-01 0.001 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.971724e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.971879e-01 0.001 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.972266e-01 0.001 0 0
Sensory perception of taste R-HSA-9717189 9.975812e-01 0.001 0 0
Selenoamino acid metabolism R-HSA-2408522 9.976857e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.977855e-01 0.001 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.981295e-01 0.001 0 0
Interleukin-1 signaling R-HSA-9020702 9.981295e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.984070e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.984125e-01 0.001 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.985066e-01 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 9.985398e-01 0.001 0 0
Parasite infection R-HSA-9664407 9.985398e-01 0.001 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.985398e-01 0.001 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.988078e-01 0.001 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.988092e-01 0.001 0 0
TCR signaling R-HSA-202403 9.989348e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.989931e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.990482e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.990837e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.992216e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992819e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.994879e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.995425e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.995676e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.996175e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996349e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.996511e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.997397e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997569e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997569e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.997756e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.998246e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.998626e-01 0.000 0 0
Neuronal System R-HSA-112316 9.998887e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999057e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999204e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999247e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999289e-01 0.000 0 0
Interleukin-1 family signaling R-HSA-446652 9.999289e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999415e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999464e-01 0.000 0 0
Immune System R-HSA-168256 9.999509e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999578e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999578e-01 0.000 0 0
Disease R-HSA-1643685 9.999671e-01 0.000 1 0
Post-translational protein modification R-HSA-597592 9.999796e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999821e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999835e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999836e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999846e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999877e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999884e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999920e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999941e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.999963e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999970e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999973e-01 0.000 0 0
Translation R-HSA-72766 9.999990e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999991e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999995e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999997e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999997e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.000000e+00 0.000 1 1
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.000000e+00 0.000 1 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.000000e+00 0.000 1 1
Diseases of cellular response to stress R-HSA-9675132 1.000000e+00 0.000 1 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 1 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
M Phase R-HSA-68886 5.817569e-14 13.235 0 0
Chromatin organization R-HSA-4839726 9.638068e-12 11.016 0 0
Chromatin modifying enzymes R-HSA-3247509 1.754503e-10 9.756 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.882272e-10 9.230 0 0
Mitotic Prophase R-HSA-68875 1.523301e-09 8.817 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.112157e-09 8.507 0 0
Mitotic Prometaphase R-HSA-68877 3.624861e-09 8.441 0 0
Cell Cycle Checkpoints R-HSA-69620 4.264633e-09 8.370 0 0
Cellular response to heat stress R-HSA-3371556 6.072712e-09 8.217 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.867018e-08 7.543 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.549503e-08 7.450 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.291931e-08 7.367 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.879928e-08 7.162 0 0
Cellular Senescence R-HSA-2559583 8.282131e-08 7.082 1 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.411034e-07 6.850 0 0
HATs acetylate histones R-HSA-3214847 2.205060e-07 6.657 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.776637e-07 6.423 0 0
Apoptotic execution phase R-HSA-75153 4.437223e-07 6.353 0 0
G2/M Checkpoints R-HSA-69481 5.475547e-07 6.262 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.744696e-07 6.171 1 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.471467e-07 6.127 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 9.149396e-07 6.039 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.218279e-06 5.914 0 0
HDACs deacetylate histones R-HSA-3214815 1.068974e-06 5.971 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.161044e-06 5.935 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.218279e-06 5.914 0 0
Mitotic Anaphase R-HSA-68882 1.216592e-06 5.915 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.131088e-06 5.947 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.356701e-06 5.868 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.411081e-06 5.850 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.516212e-06 5.819 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.576924e-06 5.802 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.665907e-06 5.778 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.702694e-06 5.769 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.788928e-06 5.747 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.943497e-06 5.711 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.186051e-06 5.497 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.305071e-06 5.481 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.483580e-06 5.458 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.483580e-06 5.458 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.137715e-06 5.383 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.032246e-06 5.298 0 0
Signal Transduction R-HSA-162582 6.248786e-06 5.204 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.588673e-06 5.181 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.698066e-06 5.114 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.312344e-06 5.080 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.883431e-06 5.005 1 1
Cell junction organization R-HSA-446728 1.037777e-05 4.984 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.119742e-05 4.951 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.112087e-05 4.954 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.475950e-05 4.831 0 0
Separation of Sister Chromatids R-HSA-2467813 1.498028e-05 4.824 0 0
Cell-Cell communication R-HSA-1500931 1.510247e-05 4.821 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.675030e-05 4.776 0 0
Cellular responses to stress R-HSA-2262752 1.638709e-05 4.785 1 0
HCMV Early Events R-HSA-9609690 1.823998e-05 4.739 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.823998e-05 4.739 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.778873e-05 4.750 0 0
Gene expression (Transcription) R-HSA-74160 1.825583e-05 4.739 1 0
Nuclear import of Rev protein R-HSA-180746 1.928591e-05 4.715 0 0
mRNA Splicing R-HSA-72172 2.024896e-05 4.694 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.138150e-05 4.670 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.142463e-05 4.669 0 0
Gene Silencing by RNA R-HSA-211000 2.344301e-05 4.630 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.830127e-05 4.548 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.830127e-05 4.548 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.387697e-05 4.470 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.227640e-05 4.491 0 0
Recycling pathway of L1 R-HSA-437239 3.461577e-05 4.461 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.886357e-05 4.410 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.081043e-05 4.389 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.100184e-05 4.387 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.802673e-05 4.319 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.194460e-05 4.284 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.204053e-05 4.284 0 0
Diseases of programmed cell death R-HSA-9645723 5.654675e-05 4.248 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.823967e-05 4.235 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.175618e-05 4.209 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.254040e-05 4.204 0 0
Apoptosis R-HSA-109581 6.366885e-05 4.196 0 0
DNA methylation R-HSA-5334118 7.126080e-05 4.147 0 0
Adherens junctions interactions R-HSA-418990 7.368099e-05 4.133 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.877107e-05 4.104 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.169287e-05 4.088 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.174682e-05 4.088 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.915138e-05 4.004 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.915138e-05 4.004 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.915138e-05 4.004 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.779748e-05 4.010 0 0
Signaling by RAS mutants R-HSA-6802949 9.915138e-05 4.004 0 0
L1CAM interactions R-HSA-373760 9.674252e-05 4.014 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.970394e-05 4.001 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.014709e-04 3.994 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.046726e-04 3.980 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.046726e-04 3.980 0 0
Cellular responses to stimuli R-HSA-8953897 1.124542e-04 3.949 1 0
PRC2 methylates histones and DNA R-HSA-212300 1.252782e-04 3.902 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.268450e-04 3.897 0 0
DNA Double Strand Break Response R-HSA-5693606 1.306817e-04 3.884 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.463189e-04 3.835 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.542631e-04 3.812 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.444061e-04 3.840 0 0
Signaling by Hippo R-HSA-2028269 1.552121e-04 3.809 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.730417e-04 3.762 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.786124e-04 3.748 0 0
Defective pyroptosis R-HSA-9710421 1.877159e-04 3.726 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.056370e-04 3.687 0 0
mTORC1-mediated signalling R-HSA-166208 2.020470e-04 3.695 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.089805e-04 3.680 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.161356e-04 3.665 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.279217e-04 3.642 0 0
HSF1-dependent transactivation R-HSA-3371571 2.532286e-04 3.596 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.722111e-04 3.565 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.722111e-04 3.565 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.790029e-04 3.554 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.941579e-04 3.531 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.920849e-04 3.534 0 0
Homology Directed Repair R-HSA-5693538 2.911629e-04 3.536 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.941579e-04 3.531 0 0
G2/M Transition R-HSA-69275 3.106526e-04 3.508 0 0
Metabolism of RNA R-HSA-8953854 3.300804e-04 3.481 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.309378e-04 3.480 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.380900e-04 3.471 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.554560e-04 3.449 0 0
Meiotic synapsis R-HSA-1221632 3.572159e-04 3.447 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.704117e-04 3.431 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.460124e-04 3.461 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.721755e-04 3.429 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.679255e-04 3.434 0 0
Glycolysis R-HSA-70171 3.607049e-04 3.443 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.554560e-04 3.449 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.787311e-04 3.422 0 0
Signaling by ALK in cancer R-HSA-9700206 3.787311e-04 3.422 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.192529e-04 3.378 1 1
Signaling by RAF1 mutants R-HSA-9656223 4.301620e-04 3.366 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.301620e-04 3.366 0 0
HCMV Infection R-HSA-9609646 4.700096e-04 3.328 0 0
Developmental Biology R-HSA-1266738 4.900565e-04 3.310 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.947199e-04 3.306 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.993494e-04 3.302 0 0
Cell-cell junction organization R-HSA-421270 5.045080e-04 3.297 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.551004e-04 3.256 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.752057e-04 3.240 1 0
Oncogenic MAPK signaling R-HSA-6802957 6.171417e-04 3.210 0 0
RNA Polymerase I Transcription R-HSA-73864 6.457353e-04 3.190 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.840350e-04 3.234 0 0
RNA Polymerase II Transcription R-HSA-73857 6.468789e-04 3.189 1 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.092189e-04 3.149 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.092189e-04 3.149 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.148994e-04 3.146 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.217409e-04 3.142 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.604213e-04 3.119 0 0
Interferon Signaling R-HSA-913531 7.687939e-04 3.114 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.836454e-04 3.106 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.889610e-04 3.103 0 0
Axon guidance R-HSA-422475 8.305398e-04 3.081 0 0
PKR-mediated signaling R-HSA-9833482 8.347880e-04 3.078 0 0
Nucleosome assembly R-HSA-774815 8.762165e-04 3.057 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.762165e-04 3.057 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.762165e-04 3.057 0 0
mRNA 3'-end processing R-HSA-72187 9.084175e-04 3.042 0 0
Aggrephagy R-HSA-9646399 9.731020e-04 3.012 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.458716e-04 3.024 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.007583e-03 2.997 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.034387e-03 2.985 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.040155e-03 2.983 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.055610e-03 2.976 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.089537e-03 2.963 0 0
Nervous system development R-HSA-9675108 1.185866e-03 2.926 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.217348e-03 2.915 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.357848e-03 2.867 0 0
Activation of BH3-only proteins R-HSA-114452 1.360270e-03 2.866 0 0
MAP2K and MAPK activation R-HSA-5674135 1.376640e-03 2.861 0 0
Programmed Cell Death R-HSA-5357801 1.476004e-03 2.831 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.484913e-03 2.828 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.510255e-03 2.821 0 0
Meiosis R-HSA-1500620 1.525266e-03 2.817 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.600141e-03 2.796 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.600141e-03 2.796 0 0
MTOR signalling R-HSA-165159 1.625122e-03 2.789 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.788477e-03 2.748 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.737600e-03 2.760 0 0
Gap junction trafficking and regulation R-HSA-157858 1.658390e-03 2.780 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.827181e-03 2.738 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.658988e-03 2.780 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.729057e-03 2.762 0 0
Deubiquitination R-HSA-5688426 2.120984e-03 2.673 0 0
Meiotic recombination R-HSA-912446 2.226736e-03 2.652 0 0
Gap junction trafficking R-HSA-190828 2.233151e-03 2.651 0 0
Membrane Trafficking R-HSA-199991 2.353217e-03 2.628 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.359434e-03 2.627 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.389358e-03 2.622 0 0
snRNP Assembly R-HSA-191859 2.479555e-03 2.606 0 0
Metabolism of non-coding RNA R-HSA-194441 2.479555e-03 2.606 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.586216e-03 2.587 0 0
Packaging Of Telomere Ends R-HSA-171306 2.614212e-03 2.583 0 0
Glucose metabolism R-HSA-70326 2.837649e-03 2.547 0 0
Formation of annular gap junctions R-HSA-196025 2.876080e-03 2.541 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.876080e-03 2.541 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.885981e-03 2.540 0 0
Generic Transcription Pathway R-HSA-212436 2.915190e-03 2.535 1 0
Attenuation phase R-HSA-3371568 3.006434e-03 2.522 0 0
Interleukin-12 signaling R-HSA-9020591 3.145340e-03 2.502 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.208519e-03 2.494 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.223460e-03 2.492 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.144979e-03 2.382 0 0
Gap junction degradation R-HSA-190873 4.144979e-03 2.382 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.907101e-03 2.408 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.683542e-03 2.434 0 0
Polo-like kinase mediated events R-HSA-156711 4.227899e-03 2.374 0 0
Chromosome Maintenance R-HSA-73886 4.013096e-03 2.397 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.144979e-03 2.382 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.227899e-03 2.374 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.924779e-03 2.406 0 0
tRNA processing in the nucleus R-HSA-6784531 3.633859e-03 2.440 0 0
Signaling by EGFR R-HSA-177929 4.370591e-03 2.359 0 0
Signaling by NOTCH R-HSA-157118 4.434531e-03 2.353 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.575442e-03 2.340 1 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.732382e-03 2.325 0 0
Depyrimidination R-HSA-73928 4.732382e-03 2.325 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.856008e-03 2.314 0 0
Interleukin-12 family signaling R-HSA-447115 4.869245e-03 2.313 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.952998e-03 2.305 0 0
Deadenylation of mRNA R-HSA-429947 5.035840e-03 2.298 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.127129e-03 2.290 0 0
Host Interactions of HIV factors R-HSA-162909 5.140076e-03 2.289 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 5.236060e-03 2.281 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.330257e-03 2.273 0 0
S Phase R-HSA-69242 6.027754e-03 2.220 0 0
HDMs demethylate histones R-HSA-3214842 6.082963e-03 2.216 0 0
HIV Life Cycle R-HSA-162587 6.115826e-03 2.214 0 0
HCMV Late Events R-HSA-9610379 6.115826e-03 2.214 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.227780e-03 2.206 0 0
DNA Repair R-HSA-73894 6.390977e-03 2.194 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.416262e-03 2.193 0 0
Base Excision Repair R-HSA-73884 6.509202e-03 2.186 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.557097e-03 2.183 0 0
Centrosome maturation R-HSA-380287 6.587608e-03 2.181 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.765017e-03 2.170 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.105901e-03 2.148 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.347340e-03 2.134 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.445504e-03 2.128 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.527121e-03 2.123 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.593491e-03 2.120 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.886078e-03 2.103 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.027368e-03 2.095 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.601767e-03 2.018 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.370629e-03 2.077 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.727176e-03 2.012 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.699197e-03 2.013 1 0
PKMTs methylate histone lysines R-HSA-3214841 9.814706e-03 2.008 0 0
DNA Replication R-HSA-69306 8.530375e-03 2.069 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.727176e-03 2.012 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.908341e-03 2.004 0 0
HIV Infection R-HSA-162906 1.015838e-02 1.993 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.022540e-02 1.990 0 0
Activation of RAC1 R-HSA-428540 1.027668e-02 1.988 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.027668e-02 1.988 0 0
Autophagy R-HSA-9612973 1.040174e-02 1.983 0 0
Post NMDA receptor activation events R-HSA-438064 1.053299e-02 1.977 0 0
Selective autophagy R-HSA-9663891 1.151089e-02 1.939 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.152040e-02 1.939 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.152040e-02 1.939 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.152040e-02 1.939 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.157501e-02 1.936 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.157501e-02 1.936 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.157501e-02 1.936 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.168976e-02 1.932 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.206861e-02 1.918 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.317754e-02 1.880 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.317754e-02 1.880 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.317754e-02 1.880 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.317754e-02 1.880 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.317754e-02 1.880 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.317754e-02 1.880 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.317754e-02 1.880 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.324570e-02 1.878 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.324570e-02 1.878 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.324570e-02 1.878 0 0
HSF1 activation R-HSA-3371511 1.348757e-02 1.870 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.368003e-02 1.864 0 0
Telomere Maintenance R-HSA-157579 1.424265e-02 1.846 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.497784e-02 1.825 0 0
Cleavage of the damaged purine R-HSA-110331 1.541032e-02 1.812 0 0
Ephrin signaling R-HSA-3928664 1.566473e-02 1.805 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.582533e-02 1.801 0 0
UCH proteinases R-HSA-5689603 1.597469e-02 1.797 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.616238e-02 1.791 0 0
EGFR downregulation R-HSA-182971 1.616238e-02 1.791 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.636846e-02 1.786 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.639280e-02 1.785 0 0
Neurodegenerative Diseases R-HSA-8863678 1.639280e-02 1.785 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.639280e-02 1.785 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.639280e-02 1.785 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.657814e-02 1.780 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.674464e-02 1.776 1 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.674464e-02 1.776 1 1
Frs2-mediated activation R-HSA-170968 1.674464e-02 1.776 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.092376e-02 1.679 0 0
Calcineurin activates NFAT R-HSA-2025928 2.092376e-02 1.679 0 0
ALK mutants bind TKIs R-HSA-9700645 2.092376e-02 1.679 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.129815e-02 1.672 0 0
G0 and Early G1 R-HSA-1538133 1.860385e-02 1.730 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.129815e-02 1.672 0 0
Unwinding of DNA R-HSA-176974 2.092376e-02 1.679 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.091486e-02 1.680 0 0
Macroautophagy R-HSA-1632852 2.108130e-02 1.676 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.047706e-02 1.689 0 0
Depurination R-HSA-73927 1.752718e-02 1.756 0 0
Viral Infection Pathways R-HSA-9824446 2.132323e-02 1.671 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.232060e-02 1.651 0 0
Myogenesis R-HSA-525793 2.232060e-02 1.651 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.244765e-02 1.649 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.324617e-02 1.634 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.324617e-02 1.634 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.324617e-02 1.634 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.356234e-02 1.628 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.356234e-02 1.628 0 0
Inositol phosphate metabolism R-HSA-1483249 2.431705e-02 1.614 0 0
NRAGE signals death through JNK R-HSA-193648 2.501294e-02 1.602 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.501294e-02 1.602 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.514279e-02 1.600 0 0
NGF-stimulated transcription R-HSA-9031628 2.531686e-02 1.597 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.531686e-02 1.597 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.577890e-02 1.589 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.593007e-02 1.586 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.593007e-02 1.586 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.698114e-02 1.569 0 0
RAF activation R-HSA-5673000 2.749325e-02 1.561 0 0
Gap junction assembly R-HSA-190861 2.749325e-02 1.561 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.802957e-02 1.552 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.802957e-02 1.552 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.942047e-02 1.531 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.958608e-02 1.529 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.032735e-02 1.518 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.074160e-02 1.512 0 0
Prolonged ERK activation events R-HSA-169893 3.074160e-02 1.512 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.110211e-02 1.507 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.260847e-02 1.487 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.260847e-02 1.487 0 0
Signaling by NTRKs R-HSA-166520 3.353241e-02 1.475 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.395773e-02 1.469 0 0
G1/S-Specific Transcription R-HSA-69205 3.483652e-02 1.458 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.665647e-02 1.436 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.896294e-02 1.409 0 0
Influenza Infection R-HSA-168255 4.006249e-02 1.397 0 0
ESR-mediated signaling R-HSA-8939211 4.099578e-02 1.387 0 0
Smooth Muscle Contraction R-HSA-445355 4.119896e-02 1.385 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.136913e-02 1.383 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.136913e-02 1.383 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.171990e-02 1.380 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.194696e-02 1.377 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.194696e-02 1.377 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.248724e-02 1.372 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.259448e-02 1.371 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.422618e-02 1.354 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.548590e-02 1.342 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.712768e-02 1.327 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.712768e-02 1.327 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.760003e-02 1.322 0 0
DNA strand elongation R-HSA-69190 4.853827e-02 1.314 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.912546e-02 1.309 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.045444e-02 1.297 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.045444e-02 1.297 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.087383e-02 1.294 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.087383e-02 1.294 0 0
Reproduction R-HSA-1474165 5.260908e-02 1.279 0 0
TGFBR3 expression R-HSA-9839394 5.373482e-02 1.270 0 0
PTEN Regulation R-HSA-6807070 5.393261e-02 1.268 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.425241e-02 1.266 0 0
MET interacts with TNS proteins R-HSA-8875513 6.967272e-02 1.157 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.629443e-02 1.250 0 0
SOS-mediated signalling R-HSA-112412 5.629443e-02 1.250 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.629443e-02 1.250 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.047722e-02 1.152 0 0
Type I hemidesmosome assembly R-HSA-446107 7.047722e-02 1.152 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.047722e-02 1.152 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.047722e-02 1.152 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.811698e-02 1.167 0 0
Striated Muscle Contraction R-HSA-390522 6.036936e-02 1.219 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.867644e-02 1.232 0 0
Signal transduction by L1 R-HSA-445144 6.691262e-02 1.174 0 0
Signaling by WNT R-HSA-195721 6.189204e-02 1.208 0 0
Rap1 signalling R-HSA-392517 5.835083e-02 1.234 0 0
Regulation of CDH1 Function R-HSA-9764561 5.801225e-02 1.236 0 0
Protein folding R-HSA-391251 6.208935e-02 1.207 0 0
Cilium Assembly R-HSA-5617833 6.577169e-02 1.182 0 0
Protein ubiquitination R-HSA-8852135 5.912982e-02 1.228 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.720857e-02 1.173 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.745516e-02 1.241 0 0
Kinesins R-HSA-983189 7.320384e-02 1.135 0 0
Regulation of TP53 Activity R-HSA-5633007 6.150268e-02 1.211 0 0
Signalling to ERKs R-HSA-187687 7.382294e-02 1.132 0 0
Signaling by ROBO receptors R-HSA-376176 7.444150e-02 1.128 0 0
MAPK family signaling cascades R-HSA-5683057 7.963883e-02 1.099 0 0
RUNX2 regulates bone development R-HSA-8941326 8.116091e-02 1.091 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.235933e-02 1.084 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 8.235933e-02 1.084 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 8.235933e-02 1.084 0 0
Erythropoietin activates RAS R-HSA-9027284 8.331094e-02 1.079 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.331094e-02 1.079 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.331094e-02 1.079 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.331094e-02 1.079 0 0
DCC mediated attractive signaling R-HSA-418885 8.331094e-02 1.079 0 0
RMTs methylate histone arginines R-HSA-3214858 8.374241e-02 1.077 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.376343e-02 1.077 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.452062e-02 1.073 0 0
Nucleotide Excision Repair R-HSA-5696398 8.562963e-02 1.067 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.600534e-02 1.065 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.600534e-02 1.065 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.600534e-02 1.065 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.600534e-02 1.065 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.600534e-02 1.065 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.609088e-02 1.065 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.609088e-02 1.065 0 0
Amyloid fiber formation R-HSA-977225 8.769946e-02 1.057 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.941267e-02 1.049 0 0
Activation of the pre-replicative complex R-HSA-68962 9.347045e-02 1.029 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.347045e-02 1.029 0 0
Regulation of gap junction activity R-HSA-191650 9.496821e-02 1.022 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 9.496821e-02 1.022 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 9.496821e-02 1.022 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.496821e-02 1.022 0 0
MTF1 activates gene expression R-HSA-5660489 9.496821e-02 1.022 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.496821e-02 1.022 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.592137e-02 1.018 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.608284e-02 1.017 0 0
FGFR2 alternative splicing R-HSA-6803529 9.651182e-02 1.015 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.651182e-02 1.015 0 0
Signaling by NOTCH3 R-HSA-9012852 9.812656e-02 1.008 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.831179e-02 1.007 0 0
Signaling by TGFBR3 R-HSA-9839373 9.831179e-02 1.007 0 0
G1/S Transition R-HSA-69206 1.021166e-01 0.991 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.029763e-01 0.987 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.030209e-01 0.987 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.030209e-01 0.987 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.030209e-01 0.987 0 0
Signal attenuation R-HSA-74749 1.030209e-01 0.987 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.030209e-01 0.987 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.060997e-01 0.974 0 0
EPH-Ephrin signaling R-HSA-2682334 1.072176e-01 0.970 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.076354e-01 0.968 0 0
Vesicle-mediated transport R-HSA-5653656 1.078711e-01 0.967 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.093682e-01 0.961 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.093682e-01 0.961 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.093682e-01 0.961 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.093682e-01 0.961 0 0
Death Receptor Signaling R-HSA-73887 1.118374e-01 0.951 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.224089e-01 0.912 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.224089e-01 0.912 0 0
IRS activation R-HSA-74713 1.224089e-01 0.912 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.224089e-01 0.912 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.224089e-01 0.912 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.224089e-01 0.912 0 0
NrCAM interactions R-HSA-447038 1.224089e-01 0.912 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.232048e-01 0.909 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.236047e-01 0.908 0 0
Long-term potentiation R-HSA-9620244 1.316442e-01 0.881 0 0
Interleukin-7 signaling R-HSA-1266695 1.316442e-01 0.881 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.335279e-01 0.874 0 0
Signaling by Interleukins R-HSA-449147 1.379143e-01 0.860 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.385796e-01 0.858 0 0
MHC class II antigen presentation R-HSA-2132295 1.387981e-01 0.858 0 0
Co-inhibition by PD-1 R-HSA-389948 1.397016e-01 0.855 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.403320e-01 0.853 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.403320e-01 0.853 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.403320e-01 0.853 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.579401e-01 0.802 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.579401e-01 0.802 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.514704e-01 0.820 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.514704e-01 0.820 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.514704e-01 0.820 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.817000e-01 0.741 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.817000e-01 0.741 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.127087e-01 0.672 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.127087e-01 0.672 0 0
Pervasive developmental disorders R-HSA-9005895 1.604545e-01 0.795 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.604545e-01 0.795 0 0
Disorders of Nervous System Development R-HSA-9697154 1.604545e-01 0.795 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.444769e-01 0.840 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.444769e-01 0.840 1 1
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.873731e-01 0.727 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.047295e-01 0.689 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.119395e-01 0.674 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.449911e-01 0.839 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.705224e-01 0.768 0 0
Cyclin D associated events in G1 R-HSA-69231 1.647132e-01 0.783 1 1
G1 Phase R-HSA-69236 1.647132e-01 0.783 1 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.604545e-01 0.795 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.127087e-01 0.672 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.127087e-01 0.672 0 0
Interleukin-6 signaling R-HSA-1059683 1.813817e-01 0.741 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.566127e-01 0.805 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.074210e-01 0.683 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.435775e-01 0.843 0 0
MET promotes cell motility R-HSA-8875878 1.942950e-01 0.712 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.828477e-01 0.738 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.859236e-01 0.731 0 0
Signaling by NOTCH1 R-HSA-1980143 1.919427e-01 0.717 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.813817e-01 0.741 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.848879e-01 0.733 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.651240e-01 0.782 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.817000e-01 0.741 0 0
Inhibition of PKR R-HSA-169131 1.579401e-01 0.802 0 0
Signaling by LTK R-HSA-9842663 1.604545e-01 0.795 0 0
Regulation of KIT signaling R-HSA-1433559 2.029861e-01 0.693 0 0
TBC/RABGAPs R-HSA-8854214 1.539770e-01 0.813 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.539980e-01 0.812 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.086500e-01 0.681 0 0
Nef and signal transduction R-HSA-164944 1.817000e-01 0.741 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.859236e-01 0.731 0 0
Semaphorin interactions R-HSA-373755 1.630470e-01 0.788 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.002553e-01 0.698 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.029861e-01 0.693 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.514962e-01 0.820 0 0
Signaling by NOTCH4 R-HSA-9013694 1.738539e-01 0.760 0 0
Potential therapeutics for SARS R-HSA-9679191 2.044780e-01 0.689 0 0
SARS-CoV Infections R-HSA-9679506 1.556216e-01 0.808 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.713010e-01 0.766 0 0
G alpha (12/13) signalling events R-HSA-416482 2.108214e-01 0.676 0 0
Trafficking of AMPA receptors R-HSA-399719 2.156724e-01 0.666 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.158321e-01 0.666 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.208508e-01 0.656 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.208508e-01 0.656 0 0
Notch-HLH transcription pathway R-HSA-350054 2.225303e-01 0.653 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.225303e-01 0.653 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.229171e-01 0.652 0 0
Regulation of beta-cell development R-HSA-186712 2.231436e-01 0.651 0 0
Ub-specific processing proteases R-HSA-5689880 2.232692e-01 0.651 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.246061e-01 0.649 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.251440e-01 0.648 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.251440e-01 0.648 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.251440e-01 0.648 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.272998e-01 0.643 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.272998e-01 0.643 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.272998e-01 0.643 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.272998e-01 0.643 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.272998e-01 0.643 0 0
Inhibition of membrane repair R-HSA-9635644 2.272998e-01 0.643 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.272998e-01 0.643 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.909502e-01 0.536 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.909502e-01 0.536 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.909502e-01 0.536 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.909502e-01 0.536 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.909502e-01 0.536 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 2.909502e-01 0.536 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.909502e-01 0.536 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.909502e-01 0.536 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.909502e-01 0.536 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.909502e-01 0.536 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.909502e-01 0.536 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.493610e-01 0.457 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 3.493610e-01 0.457 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.493610e-01 0.457 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.493610e-01 0.457 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.493610e-01 0.457 0 0
Invadopodia formation R-HSA-8941237 3.493610e-01 0.457 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.441634e-01 0.612 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.757805e-01 0.559 0 0
WNT mediated activation of DVL R-HSA-201688 2.757805e-01 0.559 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.029631e-01 0.395 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.029631e-01 0.395 1 1
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.029631e-01 0.395 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.029631e-01 0.395 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.029631e-01 0.395 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.029631e-01 0.395 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.029631e-01 0.395 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.029631e-01 0.395 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.029631e-01 0.395 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.073200e-01 0.512 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.073200e-01 0.512 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.477369e-01 0.606 0 0
Phosphorylation of the APC/C R-HSA-176412 2.477369e-01 0.606 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.706522e-01 0.568 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.385805e-01 0.470 0 0
Signaling by APC mutants R-HSA-4839744 3.385805e-01 0.470 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.385805e-01 0.470 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.385805e-01 0.470 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.385805e-01 0.470 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.521522e-01 0.345 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.521522e-01 0.345 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.521522e-01 0.345 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.521522e-01 0.345 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.521522e-01 0.345 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.521522e-01 0.345 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.693939e-01 0.433 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.170329e-01 0.499 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.170329e-01 0.499 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.403075e-01 0.468 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.403075e-01 0.468 0 0
Repression of WNT target genes R-HSA-4641265 3.996220e-01 0.398 0 0
Polymerase switching R-HSA-69091 3.996220e-01 0.398 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.996220e-01 0.398 0 0
Leading Strand Synthesis R-HSA-69109 3.996220e-01 0.398 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.996220e-01 0.398 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.996220e-01 0.398 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.996220e-01 0.398 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.996220e-01 0.398 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.996220e-01 0.398 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.789440e-01 0.554 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.291522e-01 0.367 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.291522e-01 0.367 0 0
Formation of axial mesoderm R-HSA-9796292 4.291522e-01 0.367 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.866032e-01 0.413 0 0
Lagging Strand Synthesis R-HSA-69186 3.866032e-01 0.413 0 0
Signaling by Erythropoietin R-HSA-9006335 3.545926e-01 0.450 0 0
Late endosomal microautophagy R-HSA-9615710 3.545926e-01 0.450 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.545926e-01 0.450 0 0
Translation initiation complex formation R-HSA-72649 2.870839e-01 0.542 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.738597e-01 0.427 0 0
Removal of the Flap Intermediate R-HSA-69166 4.578944e-01 0.339 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.578944e-01 0.339 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.342725e-01 0.630 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.788899e-01 0.421 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.444192e-01 0.463 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.543640e-01 0.343 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.543640e-01 0.343 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.124492e-01 0.385 0 0
HIV Transcription Initiation R-HSA-167161 4.124492e-01 0.385 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.124492e-01 0.385 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.390919e-01 0.470 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.115821e-01 0.386 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.291362e-01 0.367 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.266327e-01 0.370 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.266327e-01 0.370 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.457251e-01 0.351 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.797491e-01 0.421 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.797491e-01 0.421 0 0
Signaling by NOTCH2 R-HSA-1980145 2.789440e-01 0.554 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.342725e-01 0.630 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.738597e-01 0.427 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.969702e-01 0.527 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.361894e-01 0.473 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.662654e-01 0.575 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.023822e-01 0.395 0 0
Specification of the neural plate border R-HSA-9834899 3.403075e-01 0.468 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.635233e-01 0.439 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.916759e-01 0.535 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.500212e-01 0.347 0 0
Disorders of Developmental Biology R-HSA-9675151 2.706522e-01 0.568 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.467784e-01 0.608 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.311973e-01 0.365 0 0
GAB1 signalosome R-HSA-180292 3.170329e-01 0.499 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.757805e-01 0.559 0 0
PI3K/AKT activation R-HSA-198203 3.073200e-01 0.512 0 0
Synthesis of DNA R-HSA-69239 2.298456e-01 0.639 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 2.441634e-01 0.612 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.403075e-01 0.468 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.996220e-01 0.398 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.996220e-01 0.398 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.191744e-01 0.496 0 0
FOXO-mediated transcription R-HSA-9614085 2.425745e-01 0.615 0 0
Signaling by ERBB2 R-HSA-1227986 3.686645e-01 0.433 0 0
Regulation of signaling by CBL R-HSA-912631 3.403075e-01 0.468 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.266327e-01 0.370 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.768198e-01 0.558 0 0
Signaling by WNT in cancer R-HSA-4791275 4.122037e-01 0.385 0 0
Neurexins and neuroligins R-HSA-6794361 2.608481e-01 0.584 0 0
Formation of the posterior neural plate R-HSA-9832991 3.385805e-01 0.470 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.521522e-01 0.345 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.521522e-01 0.345 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.384247e-01 0.623 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.481001e-01 0.349 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.571452e-01 0.447 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.170329e-01 0.499 0 0
Developmental Cell Lineages R-HSA-9734767 3.929245e-01 0.406 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.827311e-01 0.417 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.686645e-01 0.433 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.686645e-01 0.433 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.686645e-01 0.433 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.686645e-01 0.433 0 0
Signaling by SCF-KIT R-HSA-1433557 4.457251e-01 0.351 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.969702e-01 0.527 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.960414e-01 0.529 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.029631e-01 0.395 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.937838e-01 0.532 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.452799e-01 0.462 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.578944e-01 0.339 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.467784e-01 0.608 0 0
Adipogenesis R-HSA-9843745 2.874906e-01 0.541 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.162587e-01 0.500 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.953316e-01 0.530 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.418832e-01 0.466 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.757805e-01 0.559 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.996220e-01 0.398 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 2.909502e-01 0.536 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.441634e-01 0.612 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.757805e-01 0.559 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.029631e-01 0.395 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.029631e-01 0.395 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.073200e-01 0.512 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.477369e-01 0.606 0 0
Differentiation of T cells R-HSA-9945266 2.477369e-01 0.606 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.385805e-01 0.470 0 0
Reelin signalling pathway R-HSA-8866376 4.521522e-01 0.345 0 0
Signaling by AXIN mutants R-HSA-4839735 3.693939e-01 0.433 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.627473e-01 0.580 0 0
Budding and maturation of HIV virion R-HSA-162588 3.930777e-01 0.406 0 0
Intraflagellar transport R-HSA-5620924 3.512115e-01 0.454 0 0
Orc1 removal from chromatin R-HSA-68949 4.115821e-01 0.386 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.474253e-01 0.607 0 0
Oncogene Induced Senescence R-HSA-2559585 2.953316e-01 0.530 1 1
Listeria monocytogenes entry into host cells R-HSA-8876384 4.094774e-01 0.388 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.328020e-01 0.633 0 0
Rab regulation of trafficking R-HSA-9007101 3.396134e-01 0.469 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.592218e-01 0.586 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.821508e-01 0.550 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.457251e-01 0.351 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.636180e-01 0.579 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.073200e-01 0.512 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.738597e-01 0.427 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.578944e-01 0.339 0 0
Negative regulation of MET activity R-HSA-6807004 3.635233e-01 0.439 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.930777e-01 0.406 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.543640e-01 0.343 0 0
Signaling by MET R-HSA-6806834 2.304261e-01 0.637 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.441634e-01 0.612 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.757805e-01 0.559 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.029631e-01 0.395 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.521522e-01 0.345 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.749923e-01 0.561 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.101469e-01 0.387 0 0
Signaling by PTK6 R-HSA-8848021 4.101469e-01 0.387 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.779929e-01 0.556 0 0
MAP kinase activation R-HSA-450294 3.824828e-01 0.417 0 0
Generation of second messenger molecules R-HSA-202433 3.788899e-01 0.421 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.124492e-01 0.385 0 0
Signaling by TGFB family members R-HSA-9006936 3.644183e-01 0.438 0 0
ARMS-mediated activation R-HSA-170984 2.757805e-01 0.559 0 0
NADE modulates death signalling R-HSA-205025 4.029631e-01 0.395 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.467784e-01 0.608 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.320830e-01 0.364 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.686645e-01 0.433 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.311973e-01 0.365 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.403075e-01 0.468 0 0
Downstream signal transduction R-HSA-186763 3.930777e-01 0.406 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.345596e-01 0.630 0 0
Muscle contraction R-HSA-397014 4.355047e-01 0.361 0 0
Protein hydroxylation R-HSA-9629569 3.635233e-01 0.439 0 0
Basigin interactions R-HSA-210991 3.866032e-01 0.413 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.139001e-01 0.503 0 0
Gluconeogenesis R-HSA-70263 3.512115e-01 0.454 0 0
Suppression of apoptosis R-HSA-9635465 3.385805e-01 0.470 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.467784e-01 0.608 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.311973e-01 0.365 0 0
Signaling by VEGF R-HSA-194138 2.301446e-01 0.638 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.109948e-01 0.507 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.521522e-01 0.345 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.627129e-01 0.581 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.477369e-01 0.606 0 0
FLT3 Signaling R-HSA-9607240 2.345596e-01 0.630 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.320830e-01 0.364 0 0
Netrin-1 signaling R-HSA-373752 2.916759e-01 0.535 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.937838e-01 0.532 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.291522e-01 0.367 0 0
Signal regulatory protein family interactions R-HSA-391160 4.578944e-01 0.339 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.487585e-01 0.457 0 0
Josephin domain DUBs R-HSA-5689877 3.073200e-01 0.512 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.291522e-01 0.367 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.457251e-01 0.351 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.385805e-01 0.470 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.521522e-01 0.345 0 0
tRNA processing R-HSA-72306 3.631696e-01 0.440 0 0
OAS antiviral response R-HSA-8983711 3.996220e-01 0.398 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.578944e-01 0.339 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.500212e-01 0.347 0 0
Signaling by Leptin R-HSA-2586552 3.073200e-01 0.512 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.645584e-01 0.438 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.545926e-01 0.450 0 0
Interleukin-37 signaling R-HSA-9008059 3.738597e-01 0.427 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.686411e-01 0.329 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.686411e-01 0.329 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.713532e-01 0.327 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.713532e-01 0.327 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.713532e-01 0.327 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.762709e-01 0.322 0 0
Interleukin-6 family signaling R-HSA-6783589 4.762709e-01 0.322 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.762709e-01 0.322 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.785087e-01 0.320 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.857780e-01 0.314 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.857780e-01 0.314 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.857780e-01 0.314 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.857780e-01 0.314 0 0
Protein methylation R-HSA-8876725 4.857780e-01 0.314 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.857780e-01 0.314 0 0
Formation of the anterior neural plate R-HSA-9823739 4.857780e-01 0.314 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.870252e-01 0.312 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.946574e-01 0.306 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.946574e-01 0.306 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.972914e-01 0.303 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 4.972914e-01 0.303 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.972914e-01 0.303 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 4.972914e-01 0.303 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 4.972914e-01 0.303 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.972914e-01 0.303 0 0
Phosphorylation of Emi1 R-HSA-176417 4.972914e-01 0.303 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 4.972914e-01 0.303 0 0
Signaling by RNF43 mutants R-HSA-5340588 4.972914e-01 0.303 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.972914e-01 0.303 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 4.972914e-01 0.303 0 0
Synthesis of PS R-HSA-1483101 4.972914e-01 0.303 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.972914e-01 0.303 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.972914e-01 0.303 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.972914e-01 0.303 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 4.972914e-01 0.303 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.973676e-01 0.303 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.006234e-01 0.300 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.018761e-01 0.299 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.051450e-01 0.297 0 0
RNA Polymerase III Transcription R-HSA-74158 5.051450e-01 0.297 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.051450e-01 0.297 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.051450e-01 0.297 0 0
FLT3 signaling in disease R-HSA-9682385 5.051450e-01 0.297 0 0
RET signaling R-HSA-8853659 5.051450e-01 0.297 0 0
Interleukin-17 signaling R-HSA-448424 5.055614e-01 0.296 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.127494e-01 0.290 0 0
Killing mechanisms R-HSA-9664420 5.127494e-01 0.290 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.127494e-01 0.290 0 0
Negative regulation of FLT3 R-HSA-9706369 5.127494e-01 0.290 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.127494e-01 0.290 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.187950e-01 0.285 0 0
Metalloprotease DUBs R-HSA-5689901 5.187950e-01 0.285 0 0
TRP channels R-HSA-3295583 5.187950e-01 0.285 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.188189e-01 0.285 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.188189e-01 0.285 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.229745e-01 0.282 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.229745e-01 0.282 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.249806e-01 0.280 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.387138e-01 0.269 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.387138e-01 0.269 0 0
Signaling by LTK in cancer R-HSA-9842640 5.387138e-01 0.269 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.387138e-01 0.269 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.387138e-01 0.269 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.387138e-01 0.269 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.387138e-01 0.269 0 0
Hydrolysis of LPE R-HSA-1483152 5.387138e-01 0.269 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.387138e-01 0.269 0 0
CREB phosphorylation R-HSA-199920 5.387138e-01 0.269 0 0
RSV-host interactions R-HSA-9833110 5.387288e-01 0.269 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.387698e-01 0.269 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.387698e-01 0.269 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.387698e-01 0.269 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.387698e-01 0.269 0 0
Response to metal ions R-HSA-5660526 5.387698e-01 0.269 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.393427e-01 0.268 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.393427e-01 0.268 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.393427e-01 0.268 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.446119e-01 0.264 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.572849e-01 0.254 0 0
Heme signaling R-HSA-9707616 5.572849e-01 0.254 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.572849e-01 0.254 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.576722e-01 0.254 0 0
Signaling by FGFR in disease R-HSA-1226099 5.577575e-01 0.254 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.593768e-01 0.252 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.593768e-01 0.252 0 0
HIV elongation arrest and recovery R-HSA-167287 5.593768e-01 0.252 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.593768e-01 0.252 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.593768e-01 0.252 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.638126e-01 0.249 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.638126e-01 0.249 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.638126e-01 0.249 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.638126e-01 0.249 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.638126e-01 0.249 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.638126e-01 0.249 0 0
Immune System R-HSA-168256 5.688606e-01 0.245 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.702863e-01 0.244 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.704283e-01 0.244 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.745016e-01 0.241 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.767254e-01 0.239 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.767254e-01 0.239 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.767254e-01 0.239 0 0
Disinhibition of SNARE formation R-HSA-114516 5.767254e-01 0.239 0 0
Recycling of eIF2:GDP R-HSA-72731 5.767254e-01 0.239 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 5.767254e-01 0.239 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.767254e-01 0.239 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 5.767254e-01 0.239 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.767254e-01 0.239 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.767254e-01 0.239 0 0
PTK6 Expression R-HSA-8849473 5.767254e-01 0.239 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.767254e-01 0.239 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 5.767254e-01 0.239 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.767254e-01 0.239 0 0
VLDL clearance R-HSA-8964046 5.767254e-01 0.239 0 0
Regulation of PTEN localization R-HSA-8948747 5.767254e-01 0.239 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.767254e-01 0.239 0 0
CHL1 interactions R-HSA-447041 5.767254e-01 0.239 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.767254e-01 0.239 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.767254e-01 0.239 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.767254e-01 0.239 0 0
mRNA Capping R-HSA-72086 5.788751e-01 0.237 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.788751e-01 0.237 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.788751e-01 0.237 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.869428e-01 0.231 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.869428e-01 0.231 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.878623e-01 0.231 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.878623e-01 0.231 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.878623e-01 0.231 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.878623e-01 0.231 0 0
Tie2 Signaling R-HSA-210993 5.878623e-01 0.231 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.878623e-01 0.231 0 0
Nephron development R-HSA-9831926 5.878623e-01 0.231 0 0
Mismatch Repair R-HSA-5358508 5.878623e-01 0.231 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.909629e-01 0.228 0 0
Peptide chain elongation R-HSA-156902 5.935257e-01 0.227 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.978200e-01 0.223 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.978200e-01 0.223 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.014135e-01 0.221 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.109126e-01 0.214 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.109126e-01 0.214 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.109126e-01 0.214 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.116068e-01 0.214 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.116068e-01 0.214 0 0
MET receptor recycling R-HSA-8875656 6.116068e-01 0.214 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.116068e-01 0.214 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.116068e-01 0.214 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.116068e-01 0.214 0 0
Regulation by c-FLIP R-HSA-3371378 6.116068e-01 0.214 0 0
Adrenoceptors R-HSA-390696 6.116068e-01 0.214 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.116068e-01 0.214 0 0
Dimerization of procaspase-8 R-HSA-69416 6.116068e-01 0.214 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.116068e-01 0.214 0 0
Sodium/Proton exchangers R-HSA-425986 6.116068e-01 0.214 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.155922e-01 0.211 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.161980e-01 0.210 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.223323e-01 0.206 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.277427e-01 0.202 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.294701e-01 0.201 0 0
Signaling by FGFR2 R-HSA-5654738 6.310243e-01 0.200 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.329648e-01 0.199 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.329648e-01 0.199 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.329648e-01 0.199 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.329648e-01 0.199 0 0
Nephrin family interactions R-HSA-373753 6.329648e-01 0.199 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.329648e-01 0.199 0 0
Signaling by NODAL R-HSA-1181150 6.329648e-01 0.199 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.339990e-01 0.198 0 0
Transcription of the HIV genome R-HSA-167172 6.361098e-01 0.196 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.361098e-01 0.196 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.430395e-01 0.192 0 0
TNF signaling R-HSA-75893 6.430395e-01 0.192 0 0
Ion homeostasis R-HSA-5578775 6.430395e-01 0.192 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.436155e-01 0.191 0 0
Lipophagy R-HSA-9613354 6.436155e-01 0.191 0 0
CASP8 activity is inhibited R-HSA-5218900 6.436155e-01 0.191 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.436155e-01 0.191 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.436155e-01 0.191 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.436155e-01 0.191 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.436155e-01 0.191 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.436155e-01 0.191 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.436155e-01 0.191 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.436155e-01 0.191 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.436155e-01 0.191 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.436155e-01 0.191 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.436155e-01 0.191 0 0
Integrin signaling R-HSA-354192 6.512167e-01 0.186 0 0
G-protein beta:gamma signalling R-HSA-397795 6.512167e-01 0.186 0 0
Nuclear RNA decay R-HSA-9930044 6.512167e-01 0.186 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.540269e-01 0.184 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.540269e-01 0.184 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.540269e-01 0.184 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.540269e-01 0.184 0 0
Signalling to RAS R-HSA-167044 6.540269e-01 0.184 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.540269e-01 0.184 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.540269e-01 0.184 0 0
ERK/MAPK targets R-HSA-198753 6.540269e-01 0.184 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.604551e-01 0.180 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.604551e-01 0.180 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.673520e-01 0.176 0 0
DAG and IP3 signaling R-HSA-1489509 6.673520e-01 0.176 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.678475e-01 0.175 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.684321e-01 0.175 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.729881e-01 0.172 0 0
DNA replication initiation R-HSA-68952 6.729881e-01 0.172 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.729881e-01 0.172 0 0
Regulation of CDH11 function R-HSA-9762292 6.729881e-01 0.172 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.729881e-01 0.172 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.729881e-01 0.172 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.729881e-01 0.172 0 0
Interleukin-27 signaling R-HSA-9020956 6.729881e-01 0.172 0 0
Formation of intermediate mesoderm R-HSA-9761174 6.729881e-01 0.172 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 6.729881e-01 0.172 0 0
2-LTR circle formation R-HSA-164843 6.729881e-01 0.172 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.729881e-01 0.172 0 0
Pexophagy R-HSA-9664873 6.729881e-01 0.172 0 0
Sperm Motility And Taxes R-HSA-1300642 6.729881e-01 0.172 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.729881e-01 0.172 0 0
Formation of apoptosome R-HSA-111458 6.729881e-01 0.172 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.729881e-01 0.172 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.741122e-01 0.171 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.741122e-01 0.171 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.741122e-01 0.171 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.742593e-01 0.171 0 0
Platelet degranulation R-HSA-114608 6.748203e-01 0.171 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.797251e-01 0.168 0 0
Diseases of DNA repair R-HSA-9675135 6.813946e-01 0.167 0 0
Dual Incision in GG-NER R-HSA-5696400 6.838908e-01 0.165 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.838908e-01 0.165 0 0
Mitophagy R-HSA-5205647 6.838908e-01 0.165 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.896639e-01 0.161 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.896639e-01 0.161 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.931102e-01 0.159 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.932387e-01 0.159 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.932387e-01 0.159 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.932387e-01 0.159 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.932387e-01 0.159 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.932387e-01 0.159 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.932387e-01 0.159 0 0
Signaling by KIT in disease R-HSA-9669938 6.932387e-01 0.159 0 0
LDL clearance R-HSA-8964038 6.932387e-01 0.159 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.950163e-01 0.158 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.955875e-01 0.158 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.967052e-01 0.157 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.969067e-01 0.157 0 0
Regulation of Apoptosis R-HSA-169911 6.993484e-01 0.155 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.999414e-01 0.155 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.999414e-01 0.155 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.999414e-01 0.155 0 0
vRNA Synthesis R-HSA-192814 6.999414e-01 0.155 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.999414e-01 0.155 0 0
Bicarbonate transporters R-HSA-425381 6.999414e-01 0.155 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.999414e-01 0.155 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.999414e-01 0.155 0 0
PECAM1 interactions R-HSA-210990 6.999414e-01 0.155 0 0
Interleukin-2 signaling R-HSA-9020558 6.999414e-01 0.155 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.999414e-01 0.155 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.001478e-01 0.155 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.040798e-01 0.152 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.053752e-01 0.152 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.053752e-01 0.152 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.053752e-01 0.152 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.114279e-01 0.148 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.114279e-01 0.148 0 0
Syndecan interactions R-HSA-3000170 7.114279e-01 0.148 0 0
Growth hormone receptor signaling R-HSA-982772 7.114279e-01 0.148 0 0
Calmodulin induced events R-HSA-111933 7.142244e-01 0.146 0 0
CaM pathway R-HSA-111997 7.142244e-01 0.146 0 0
Glycosphingolipid transport R-HSA-9845576 7.142244e-01 0.146 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.167025e-01 0.145 0 0
Signaling by PDGF R-HSA-186797 7.177001e-01 0.144 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.182929e-01 0.144 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.182929e-01 0.144 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.182929e-01 0.144 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.200785e-01 0.143 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.200785e-01 0.143 0 0
DNA Damage Bypass R-HSA-73893 7.209954e-01 0.142 0 0
Circadian clock R-HSA-9909396 7.246587e-01 0.140 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.246746e-01 0.140 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.246746e-01 0.140 0 0
Integration of provirus R-HSA-162592 7.246746e-01 0.140 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.246746e-01 0.140 0 0
NF-kB is activated and signals survival R-HSA-209560 7.246746e-01 0.140 0 0
Plasmalogen biosynthesis R-HSA-75896 7.246746e-01 0.140 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.246746e-01 0.140 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.246746e-01 0.140 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.246746e-01 0.140 0 0
Anchoring fibril formation R-HSA-2214320 7.246746e-01 0.140 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.246746e-01 0.140 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.285246e-01 0.138 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.287044e-01 0.137 0 0
Complex III assembly R-HSA-9865881 7.287044e-01 0.137 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.289930e-01 0.137 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.304333e-01 0.136 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.304333e-01 0.136 0 0
Hedgehog 'off' state R-HSA-5610787 7.363739e-01 0.133 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.373055e-01 0.132 0 0
Cellular response to starvation R-HSA-9711097 7.441354e-01 0.128 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.450950e-01 0.128 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.450950e-01 0.128 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.450950e-01 0.128 0 0
Infectious disease R-HSA-5663205 7.453501e-01 0.128 0 0
Adaptive Immune System R-HSA-1280218 7.459969e-01 0.127 0 0
PCP/CE pathway R-HSA-4086400 7.471977e-01 0.127 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.473705e-01 0.126 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.473705e-01 0.126 0 0
MET activates RAS signaling R-HSA-8851805 7.473705e-01 0.126 0 0
Regulation of IFNG signaling R-HSA-877312 7.473705e-01 0.126 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.473705e-01 0.126 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.473705e-01 0.126 0 0
Interleukin-35 Signalling R-HSA-8984722 7.473705e-01 0.126 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.473705e-01 0.126 0 0
Interleukin-15 signaling R-HSA-8983432 7.473705e-01 0.126 0 0
Interferon gamma signaling R-HSA-877300 7.510348e-01 0.124 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.546092e-01 0.122 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.554300e-01 0.122 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.554300e-01 0.122 0 0
Signaling by ALK R-HSA-201556 7.554300e-01 0.122 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.554300e-01 0.122 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.568178e-01 0.121 0 0
Sensory processing of sound R-HSA-9659379 7.568178e-01 0.121 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.568288e-01 0.121 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.606283e-01 0.119 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.606283e-01 0.119 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.680549e-01 0.115 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.680549e-01 0.115 0 0
HIV Transcription Elongation R-HSA-167169 7.680549e-01 0.115 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.680549e-01 0.115 0 0
Interleukin-2 family signaling R-HSA-451927 7.680549e-01 0.115 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.681967e-01 0.115 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.681967e-01 0.115 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.681967e-01 0.115 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.681967e-01 0.115 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.681967e-01 0.115 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 7.681967e-01 0.115 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.681967e-01 0.115 0 0
Maturation of nucleoprotein R-HSA-9683610 7.681967e-01 0.115 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.681967e-01 0.115 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.691825e-01 0.114 0 0
Gastrulation R-HSA-9758941 7.699781e-01 0.114 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.722188e-01 0.112 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.753343e-01 0.111 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.753343e-01 0.111 0 0
Insulin processing R-HSA-264876 7.753343e-01 0.111 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.795976e-01 0.108 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.801430e-01 0.108 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.831358e-01 0.106 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.873072e-01 0.104 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.873072e-01 0.104 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.873072e-01 0.104 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.873072e-01 0.104 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.873072e-01 0.104 0 0
Hydrolysis of LPC R-HSA-1483115 7.873072e-01 0.104 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.873072e-01 0.104 0 0
Malate-aspartate shuttle R-HSA-9856872 7.873072e-01 0.104 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.873072e-01 0.104 0 0
Zinc transporters R-HSA-435354 7.873072e-01 0.104 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.873072e-01 0.104 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.892437e-01 0.103 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.895914e-01 0.103 0 0
Parasite infection R-HSA-9664407 7.895914e-01 0.103 0 0
Leishmania phagocytosis R-HSA-9664417 7.895914e-01 0.103 0 0
Mitochondrial biogenesis R-HSA-1592230 7.913032e-01 0.102 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.917067e-01 0.101 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.963266e-01 0.099 0 0
SLC transporter disorders R-HSA-5619102 8.017191e-01 0.096 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.023879e-01 0.096 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.027594e-01 0.095 0 0
Ca-dependent events R-HSA-111996 8.027594e-01 0.095 0 0
Eukaryotic Translation Termination R-HSA-72764 8.039880e-01 0.095 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.048432e-01 0.094 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.048432e-01 0.094 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.048432e-01 0.094 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.048432e-01 0.094 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.048432e-01 0.094 0 0
p75NTR signals via NF-kB R-HSA-193639 8.048432e-01 0.094 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.048432e-01 0.094 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.048432e-01 0.094 0 0
p38MAPK events R-HSA-171007 8.048432e-01 0.094 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.048432e-01 0.094 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.077230e-01 0.093 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.146555e-01 0.089 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.147986e-01 0.089 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.183165e-01 0.087 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.193762e-01 0.087 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.209343e-01 0.086 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.209343e-01 0.086 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.209343e-01 0.086 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.209343e-01 0.086 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.209343e-01 0.086 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.209343e-01 0.086 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.209343e-01 0.086 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.209343e-01 0.086 0 0
Activation of SMO R-HSA-5635838 8.209343e-01 0.086 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.240752e-01 0.084 0 0
Ca2+ pathway R-HSA-4086398 8.241762e-01 0.084 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.242149e-01 0.084 0 0
Signaling by FGFR R-HSA-190236 8.256477e-01 0.083 0 0
Extension of Telomeres R-HSA-180786 8.264805e-01 0.083 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.264805e-01 0.083 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.265072e-01 0.083 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.265072e-01 0.083 0 0
Cargo concentration in the ER R-HSA-5694530 8.265072e-01 0.083 0 0
Pyruvate metabolism R-HSA-70268 8.314884e-01 0.080 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.329927e-01 0.079 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.329927e-01 0.079 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.329927e-01 0.079 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.349390e-01 0.078 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.356996e-01 0.078 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.356996e-01 0.078 0 0
Coenzyme A biosynthesis R-HSA-196783 8.356996e-01 0.078 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.356996e-01 0.078 0 0
Fibronectin matrix formation R-HSA-1566977 8.356996e-01 0.078 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.356996e-01 0.078 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.356996e-01 0.078 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.404784e-01 0.075 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.421446e-01 0.075 0 0
PLC beta mediated events R-HSA-112043 8.430502e-01 0.074 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.451067e-01 0.073 0 0
Selenocysteine synthesis R-HSA-2408557 8.453821e-01 0.073 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.479433e-01 0.072 0 0
Cardiogenesis R-HSA-9733709 8.479433e-01 0.072 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.492482e-01 0.071 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.492482e-01 0.071 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.492482e-01 0.071 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.492482e-01 0.071 0 0
Glycogen storage diseases R-HSA-3229121 8.492482e-01 0.071 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.492482e-01 0.071 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.492482e-01 0.071 0 0
Mitochondrial protein import R-HSA-1268020 8.508231e-01 0.070 0 0
PI Metabolism R-HSA-1483255 8.515478e-01 0.070 0 0
Ribosome-associated quality control R-HSA-9948299 8.556496e-01 0.068 0 0
Viral mRNA Translation R-HSA-192823 8.575132e-01 0.067 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.577322e-01 0.067 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.577322e-01 0.067 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.582674e-01 0.066 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.582674e-01 0.066 0 0
Co-stimulation by CD28 R-HSA-389356 8.591508e-01 0.066 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.605133e-01 0.065 0 0
Toll-like Receptor Cascades R-HSA-168898 8.615328e-01 0.065 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.616803e-01 0.065 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.616803e-01 0.065 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.616803e-01 0.065 0 0
Apoptotic factor-mediated response R-HSA-111471 8.616803e-01 0.065 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.616803e-01 0.065 0 0
IRE1alpha activates chaperones R-HSA-381070 8.643002e-01 0.063 0 0
Ion transport by P-type ATPases R-HSA-936837 8.653925e-01 0.063 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.669416e-01 0.062 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.669416e-01 0.062 0 0
Hyaluronan metabolism R-HSA-2142845 8.669416e-01 0.062 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.669416e-01 0.062 0 0
Degradation of CDH1 R-HSA-9766229 8.670355e-01 0.062 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.670355e-01 0.062 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.670355e-01 0.062 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.670355e-01 0.062 0 0
Cellular response to hypoxia R-HSA-1234174 8.722080e-01 0.059 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.730878e-01 0.059 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.730878e-01 0.059 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.730878e-01 0.059 0 0
Pyrimidine biosynthesis R-HSA-500753 8.730878e-01 0.059 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.730878e-01 0.059 0 0
The NLRP3 inflammasome R-HSA-844456 8.730878e-01 0.059 0 0
Diseases of hemostasis R-HSA-9671793 8.730878e-01 0.059 0 0
Maturation of nucleoprotein R-HSA-9694631 8.730878e-01 0.059 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.730878e-01 0.059 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.730878e-01 0.059 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.745285e-01 0.058 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.745285e-01 0.058 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.756004e-01 0.058 0 0
PERK regulates gene expression R-HSA-381042 8.756004e-01 0.058 0 0
PPARA activates gene expression R-HSA-1989781 8.763483e-01 0.057 0 0
Mitochondrial protein degradation R-HSA-9837999 8.813158e-01 0.055 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.816447e-01 0.055 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.835552e-01 0.054 0 0
Glycogen synthesis R-HSA-3322077 8.835552e-01 0.054 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.835552e-01 0.054 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.835552e-01 0.054 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 8.835552e-01 0.054 0 0
Creatine metabolism R-HSA-71288 8.835552e-01 0.054 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.835552e-01 0.054 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.837367e-01 0.054 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.837367e-01 0.054 0 0
G-protein mediated events R-HSA-112040 8.849493e-01 0.053 0 0
Stimuli-sensing channels R-HSA-2672351 8.893187e-01 0.051 0 0
Degradation of DVL R-HSA-4641258 8.913779e-01 0.050 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.931598e-01 0.049 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.931598e-01 0.049 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.931598e-01 0.049 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.931598e-01 0.049 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.931598e-01 0.049 0 0
TCR signaling R-HSA-202403 8.984997e-01 0.046 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.985502e-01 0.046 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.985502e-01 0.046 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.985502e-01 0.046 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.019727e-01 0.045 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.019727e-01 0.045 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.019727e-01 0.045 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.019727e-01 0.045 0 0
Assembly Of The HIV Virion R-HSA-175474 9.019727e-01 0.045 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.038858e-01 0.044 0 0
Pentose phosphate pathway R-HSA-71336 9.052789e-01 0.043 0 0
Stabilization of p53 R-HSA-69541 9.052789e-01 0.043 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 9.052789e-01 0.043 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.100591e-01 0.041 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.100591e-01 0.041 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.100591e-01 0.041 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.100591e-01 0.041 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.115884e-01 0.040 0 0
Diseases of Immune System R-HSA-5260271 9.115884e-01 0.040 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.115884e-01 0.040 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.115884e-01 0.040 0 0
Signaling by Hedgehog R-HSA-5358351 9.151045e-01 0.039 0 0
IRS-mediated signalling R-HSA-112399 9.172511e-01 0.038 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.174789e-01 0.037 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.174789e-01 0.037 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.174789e-01 0.037 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.174789e-01 0.037 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.174789e-01 0.037 0 0
Formation of the ureteric bud R-HSA-9830674 9.174789e-01 0.037 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.175021e-01 0.037 0 0
Maturation of spike protein R-HSA-9694548 9.175021e-01 0.037 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.176384e-01 0.037 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.180636e-01 0.037 0 0
Disease R-HSA-1643685 9.193499e-01 0.037 1 0
Signaling by ERBB4 R-HSA-1236394 9.212070e-01 0.036 0 0
Dual incision in TC-NER R-HSA-6782135 9.221343e-01 0.035 0 0
ER-Phagosome pathway R-HSA-1236974 9.227687e-01 0.035 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.230423e-01 0.035 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.230423e-01 0.035 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.242871e-01 0.034 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.242871e-01 0.034 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.242871e-01 0.034 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.242871e-01 0.034 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.242871e-01 0.034 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.305339e-01 0.031 0 0
Tight junction interactions R-HSA-420029 9.305339e-01 0.031 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.305339e-01 0.031 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.305339e-01 0.031 0 0
Hyaluronan degradation R-HSA-2160916 9.305339e-01 0.031 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.305339e-01 0.031 0 0
Fertilization R-HSA-1187000 9.305339e-01 0.031 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.305339e-01 0.031 0 0
Laminin interactions R-HSA-3000157 9.305339e-01 0.031 0 0
tRNA Aminoacylation R-HSA-379724 9.311180e-01 0.031 0 0
Signaling by FGFR4 R-HSA-5654743 9.330866e-01 0.030 0 0
Post-translational protein modification R-HSA-597592 9.332324e-01 0.030 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.352428e-01 0.029 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.352428e-01 0.029 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.362656e-01 0.029 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.362656e-01 0.029 0 0
MET activates PTK2 signaling R-HSA-8874081 9.362656e-01 0.029 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.362656e-01 0.029 0 0
Urea cycle R-HSA-70635 9.362656e-01 0.029 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.362656e-01 0.029 0 0
Transmission across Chemical Synapses R-HSA-112315 9.368010e-01 0.028 0 0
Cholesterol biosynthesis R-HSA-191273 9.369784e-01 0.028 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.376305e-01 0.028 0 0
Amine ligand-binding receptors R-HSA-375280 9.376305e-01 0.028 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.391385e-01 0.027 0 0
Neutrophil degranulation R-HSA-6798695 9.400627e-01 0.027 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.415248e-01 0.026 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.415248e-01 0.026 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.415248e-01 0.026 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.415248e-01 0.026 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.415248e-01 0.026 0 0
Cristae formation R-HSA-8949613 9.415248e-01 0.026 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.415248e-01 0.026 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.415248e-01 0.026 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.415248e-01 0.026 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.415248e-01 0.026 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.415248e-01 0.026 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.418805e-01 0.026 0 0
Signaling by FGFR3 R-HSA-5654741 9.418805e-01 0.026 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.458542e-01 0.024 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.458542e-01 0.024 0 0
Insulin receptor signalling cascade R-HSA-74751 9.462870e-01 0.024 0 0
IGF1R signaling cascade R-HSA-2428924 9.462870e-01 0.024 0 0
Telomere Extension By Telomerase R-HSA-171319 9.463502e-01 0.024 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.463502e-01 0.024 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.463502e-01 0.024 0 0
Inflammasomes R-HSA-622312 9.463502e-01 0.024 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.463502e-01 0.024 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.463502e-01 0.024 0 0
Pyrimidine salvage R-HSA-73614 9.463502e-01 0.024 0 0
rRNA processing R-HSA-72312 9.464231e-01 0.024 0 0
Selenoamino acid metabolism R-HSA-2408522 9.493897e-01 0.023 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.495609e-01 0.022 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.495681e-01 0.022 0 0
DARPP-32 events R-HSA-180024 9.507777e-01 0.022 0 0
Platelet calcium homeostasis R-HSA-418360 9.507777e-01 0.022 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.507777e-01 0.022 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.507777e-01 0.022 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.526480e-01 0.021 0 0
Metal ion SLC transporters R-HSA-425410 9.530382e-01 0.021 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.546302e-01 0.020 0 0
DAP12 signaling R-HSA-2424491 9.548401e-01 0.020 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.548401e-01 0.020 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.548401e-01 0.020 0 0
Kidney development R-HSA-9830369 9.555579e-01 0.020 0 0
Protein localization R-HSA-9609507 9.570207e-01 0.019 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.571393e-01 0.019 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.590310e-01 0.018 0 0
PI3K Cascade R-HSA-109704 9.593054e-01 0.018 0 0
Azathioprine ADME R-HSA-9748787 9.593054e-01 0.018 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.619873e-01 0.017 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.619873e-01 0.017 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.621302e-01 0.017 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.647662e-01 0.016 0 0
Interferon alpha/beta signaling R-HSA-909733 9.649078e-01 0.016 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.651251e-01 0.015 0 0
Hedgehog 'on' state R-HSA-5632684 9.656027e-01 0.015 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.656565e-01 0.015 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.659583e-01 0.015 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.672252e-01 0.014 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.672252e-01 0.014 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.680040e-01 0.014 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.680040e-01 0.014 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.680040e-01 0.014 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.680040e-01 0.014 0 0
Hemostasis R-HSA-109582 9.684969e-01 0.014 0 0
Ion channel transport R-HSA-983712 9.685413e-01 0.014 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.688979e-01 0.014 0 0
Opioid Signalling R-HSA-111885 9.688979e-01 0.014 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.706455e-01 0.013 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.706455e-01 0.013 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.706455e-01 0.013 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.706455e-01 0.013 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.706455e-01 0.013 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.706455e-01 0.013 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.706455e-01 0.013 0 0
G alpha (z) signalling events R-HSA-418597 9.716568e-01 0.012 0 0
Paracetamol ADME R-HSA-9753281 9.716568e-01 0.012 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.730690e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.730690e-01 0.012 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.730690e-01 0.012 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.730690e-01 0.012 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.730690e-01 0.012 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.730690e-01 0.012 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.734781e-01 0.012 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.734781e-01 0.012 0 0
Signaling by FGFR1 R-HSA-5654736 9.736500e-01 0.012 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.752926e-01 0.011 0 0
GPVI-mediated activation cascade R-HSA-114604 9.752926e-01 0.011 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.752926e-01 0.011 0 0
Cellular response to chemical stress R-HSA-9711123 9.760832e-01 0.011 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.765189e-01 0.010 0 0
Translation of Structural Proteins R-HSA-9694635 9.767422e-01 0.010 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.772378e-01 0.010 0 0
Voltage gated Potassium channels R-HSA-1296072 9.773327e-01 0.010 0 0
Degradation of AXIN R-HSA-4641257 9.773327e-01 0.010 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.773327e-01 0.010 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.773327e-01 0.010 0 0
Collagen chain trimerization R-HSA-8948216 9.773327e-01 0.010 0 0
Metabolism of folate and pterines R-HSA-196757 9.773327e-01 0.010 0 0
Interleukin-1 family signaling R-HSA-446652 9.780277e-01 0.010 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.781306e-01 0.010 0 0
Collagen formation R-HSA-1474290 9.781306e-01 0.010 0 0
Peroxisomal protein import R-HSA-9033241 9.788497e-01 0.009 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.792045e-01 0.009 0 0
RAB geranylgeranylation R-HSA-8873719 9.803506e-01 0.009 0 0
Extracellular matrix organization R-HSA-1474244 9.805930e-01 0.009 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.809218e-01 0.008 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.809218e-01 0.008 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.817480e-01 0.008 0 0
Collagen degradation R-HSA-1442490 9.817480e-01 0.008 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.818018e-01 0.008 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.821528e-01 0.008 0 0
Glycogen metabolism R-HSA-8982491 9.824973e-01 0.008 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.824973e-01 0.008 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.824973e-01 0.008 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.828294e-01 0.008 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.839167e-01 0.007 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.839429e-01 0.007 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.839429e-01 0.007 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.843931e-01 0.007 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.852691e-01 0.006 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.852691e-01 0.006 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.852691e-01 0.006 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.852691e-01 0.006 0 0
Heme biosynthesis R-HSA-189451 9.852691e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9683701 9.852691e-01 0.006 0 0
ABC-family proteins mediated transport R-HSA-382556 9.857971e-01 0.006 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.866571e-01 0.006 0 0
Interleukin-1 signaling R-HSA-9020702 9.866571e-01 0.006 0 0
Neuronal System R-HSA-112316 9.868319e-01 0.006 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.872417e-01 0.006 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.872483e-01 0.006 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.876022e-01 0.005 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.880832e-01 0.005 0 0
Translation R-HSA-72766 9.881152e-01 0.005 0 0
DAP12 interactions R-HSA-2172127 9.886264e-01 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.886264e-01 0.005 0 0
Proteasome assembly R-HSA-9907900 9.886264e-01 0.005 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.886264e-01 0.005 0 0
Regulated Necrosis R-HSA-5218859 9.891561e-01 0.005 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.895660e-01 0.005 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.895660e-01 0.005 0 0
Somitogenesis R-HSA-9824272 9.895660e-01 0.005 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.902064e-01 0.004 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.904281e-01 0.004 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.904281e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.906669e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.906669e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.909262e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.912190e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.913431e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.918196e-01 0.004 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.918645e-01 0.004 0 0
Leishmania infection R-HSA-9658195 9.923165e-01 0.003 0 0
Parasitic Infection Pathways R-HSA-9824443 9.923165e-01 0.003 0 0
Signaling by Insulin receptor R-HSA-74752 9.926166e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.926166e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.926166e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.931091e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.937811e-01 0.003 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.937811e-01 0.003 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.942951e-01 0.002 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.946568e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.947667e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.948825e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.949040e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.949040e-01 0.002 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.951992e-01 0.002 0 0
Cardiac conduction R-HSA-5576891 9.952759e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.955088e-01 0.002 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.956245e-01 0.002 0 0
Phospholipid metabolism R-HSA-1483257 9.958585e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.959602e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.962941e-01 0.002 0 0
Integration of energy metabolism R-HSA-163685 9.967471e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.968816e-01 0.001 0 0
Neddylation R-HSA-8951664 9.968860e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.971395e-01 0.001 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.973515e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.973760e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.977921e-01 0.001 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.979747e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.983173e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.984369e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.985662e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.985662e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.986417e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.986651e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.987366e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.988934e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.988934e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.989850e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.990690e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.991333e-01 0.000 0 0
Regulation of insulin secretion R-HSA-422356 9.991371e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.991460e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.992167e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.993956e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.993956e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994456e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.994595e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.996076e-01 0.000 0 0
Downstream TCR signaling R-HSA-202424 9.998035e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998035e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998479e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998610e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999017e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999017e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999241e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999600e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.999620e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999685e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999732e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999753e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999843e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999854e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999906e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999923e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999926e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999948e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999960e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999976e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999979e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999983e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999989e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999989e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999992e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999992e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999995e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999996e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999996e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999996e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999996e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.000000e+00 0.000 1 1
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.000000e+00 0.000 1 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.000000e+00 0.000 1 1
Diseases of cellular response to stress R-HSA-9675132 1.000000e+00 0.000 1 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways