GSK3A

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O14545 T323 Sugiyama TRAFD1 FLN29 ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O15067 S1062 Sugiyama PFAS KIAA0361 SYCLPPTFPKAsVPREPGGPsPRVAILREEGSNGDREMADA
O15084 S1007 SIGNOR|EPSD|PSP ANKRD28 KIAA0379 ssssPLssLTFNAINRYTNTsKtVsFEALPIMRNEPSSYCS
O15085 S1457 Sugiyama ARHGEF11 KIAA0380 NRLKDMELAHRELLKsLGGEssGGttPVGSFHTEAARWTDG
O15085 S1458 Sugiyama ARHGEF11 KIAA0380 RLKDMELAHRELLKsLGGEssGGttPVGSFHTEAARWTDGs
O15085 T1462 Sugiyama ARHGEF11 KIAA0380 MELAHRELLKsLGGEssGGttPVGSFHTEAARWTDGsLsPP
O43432 S1409 Sugiyama EIF4G3 EGEDVHNFLLEQKLDFIEsDsPCssEALSKKELSAEELYKR
O43432 S1412 Sugiyama EIF4G3 DVHNFLLEQKLDFIEsDsPCssEALSKKELSAEELYKRLEK
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852 T65 Sugiyama CALU FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60333 T647 Sugiyama KIF1B KIAA0591 KIAA1448 GKNHVFRFNHPEQARAEREKtPsAEtPsEPVDWTFAQRELL
O60333 T652 Sugiyama KIF1B KIAA0591 KIAA1448 FRFNHPEQARAEREKtPsAEtPsEPVDWTFAQRELLEKQGI
O60701 T185 Sugiyama UGDH EGTAIKDLKNPDRVLIGGDEtPEGQRAVQALCAVYEHWVPR
O75030 S405 SIGNOR MITF BHLHE32 NRHLLLRIQELEMQARAHGLsLIPsTGLCsPDLVNRIIKQE
O75581 S1490 SIGNOR|PSP LRP6 SSSSssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPs
O75581 S1544 EPSD|PSP LRP6 HFAPPtTPCSTDVCDsDyAPsRRMtSVATAKGYTSDLNyDS
O75581 S1607 PSP LRP6 CPPsPYTERSYSHHLYPPPPsPCTDss______________
O75581 T1572 PSP LRP6 TAKGYTSDLNyDSEPVPPPPtPRSQYLSAEENyESCPPsPY
O94979 S799 Sugiyama SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 IMQLRDRLCRAQGEPVAGHEsPKIPyEKQQLPKGRPGPVAG
O95359 S2317 Sugiyama TACC2 MPLRRPKMKKtPEKLDNtPAsPPRsPAEPNDIPIAKGTYTF
O95359 S2321 Sugiyama TACC2 RPKMKKtPEKLDNtPAsPPRsPAEPNDIPIAKGTYTFDIDK
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P01106 T73 PSP MYC BHLHE39 SELQPPAPSEDIWKKFELLPtPPLsPsRRsGLCsPSyVAVT
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 S333 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 WyDNEFGysNRVVDLMAHMAsKE__________________
P04637 S33 ELM TP53 P53 PLsQEtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQW
P05412 S243 GPS6|SIGNOR|ELM|EPSD JUN QALKEEPQtVPEMPGEtPPLsPIDMEsQERIKAERKRMRNR
P05412 S249 SIGNOR JUN PQtVPEMPGEtPPLsPIDMEsQERIKAERKRMRNRIAASKC
P05412 T239 GPS6|SIGNOR|ELM|EPSD JUN HPRLQALKEEPQtVPEMPGEtPPLsPIDMEsQERIKAERKR
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07942 T1141 Sugiyama LAMB1 FWGDPDVECRACDCDPRGIEtPQCDQSTGQCVCVEGVEGPR
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P10636 S235 EPSD MAPT MAPTL MTBT1 TAU KEEVDEDRDVDESsPQDsPPsKAsPAQDGRPPQTAAREATS
P10636 S579 SIGNOR MAPT MAPTL MTBT1 TAU RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P10636 S641 SIGNOR|EPSD MAPT MAPTL MTBT1 TAU GsVQIVyKPVDLSKVTsKCGsLGNIHHKPGGGQVEVKSEKL
P10809 S225 Sugiyama HSPD1 HSP60 KtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVL
P10809 T231 Sugiyama HSPD1 HSP60 LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P10809 T455 Sugiyama HSPD1 HSP60 GIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLKIP
P10809 Y227 Sugiyama HSPD1 HSP60 LNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLs
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P13051 S64 SIGNOR|EPSD|PSP UNG DGU UNG1 UNG15 AAIPAKKAPAGQEEPGtPPssPLsAEQLDRIQRNKAAALLR
P13051 T60 SIGNOR|EPSD|PSP UNG DGU UNG1 UNG15 SGDAAAIPAKKAPAGQEEPGtPPssPLsAEQLDRIQRNKAA
P13807 S641 SIGNOR GYS1 GYS FTYEPNEADAAQGyRyPRPAsVPPsPsLsRHssPHQsEDEE
P13861 S48 Sugiyama PRKAR2A PKR2 PRKAR2 DLVEFAVEYFTRLREARAPAsVLPAAtPRQsLGHPPPEPGP
P13861 T54 Sugiyama PRKAR2A PKR2 PRKAR2 VEYFTRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADA
P14618 S37 Sugiyama PKM OIP3 PK2 PK3 PKM2 QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P14618 S55 Sugiyama PKM OIP3 PK2 PK3 PKM2 IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P14618 T41 Sugiyama PKM OIP3 PK2 PK3 PKM2 AMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtL
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16070 T47 Sugiyama CD44 LHR MDU2 MDU3 MIC4 TCRFAGVFHVEKNGRYsIsRtEAADLCKAFNSTLPTMAQME
P16220 S129 ELM CREB1 KRREILsRRPsYRKILNDLssDAPGVPRIEEEKsEEETSAP
P17661 S28 PSP DES sQRVssYRRtFGGAPGFPLGsPLssPVFPRAGFGsKGssss
P17661 S32 PSP DES ssYRRtFGGAPGFPLGsPLssPVFPRAGFGsKGssssVTSR
P17812 S571 EPSD|Sugiyama CTPS1 CTPS LSHYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD
P17812 S573 Sugiyama CTPS1 CTPS HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18669 S31 Sugiyama PGAM1 PGAMA CDABP0006 HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P20749 S402 SIGNOR|EPSD|PSP BCL3 BCL4 D19S37 SPESSSRLSSNGLLSASPSSsPSQsPPRDPPGFPMAPPNFF
P20749 S406 SIGNOR|EPSD|PSP BCL3 BCL4 D19S37 SSRLSSNGLLSASPSSsPSQsPPRDPPGFPMAPPNFFLPSP
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22415 S186 EPSD USF1 BHLHB11 USF PQEVLQGGSQRSIAPRTHPYsPKSEAPRTTRDEKRRAQHNE
P22415 T153 EPSD USF1 BHLHB11 USF SGSTAAVVTTQGSEALLGQAtPPGTGQFFVMMSPQEVLQGG
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23246 T687 SIGNOR SFPQ PSF FGQGGAGPVGGQGPRGMGPGtPAGyGRGREEYEGPNKKPRF
P23396 T220 Sugiyama RPS3 OK/SW-cl.26 PKKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPV
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P24071 S284 SIGNOR FCAR CD89 AEPSWSQQMCQPGLTFARTPsVCK_________________
P24385 T286 ELM CCND1 BCL1 PRAD1 MDPKAAEEEEEEEEEVDLACtPtDVRDVDI___________
P24864 T395 GPS6|ELM|EPSD|PSP CCNE1 CCNE AKKAMLsEQNRAsPLPsGLLtPPQsGKKQSSGPEMA_____
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27695 S135 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 SHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDEEHDQEG
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P31749 T312 SIGNOR|EPSD|PSP AKT1 PKB RAC DFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGRAVDW
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34897 S417 Sugiyama SHMT2 ERVLELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFR
P34897 T420 Sugiyama SHMT2 LELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFREDD
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P35222 S33 ELM|EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AMEPDRKAAVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPE
P35222 S37 ELM|EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 DRKAAVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDV
P35222 T41 ELM|EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDVDTsQ
P35579 S1713 Sugiyama MYH9 ERAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQ
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P38936 T57 PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 LMAGCIQEARERWNFDFVtEtPLEGDFAWERVRGLGLPKLy
P40763 S727 PSP STAT3 APRF KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P40763 T714 PSP STAT3 APRF HPEADPGsAAPyLKTKFICVtPttCsNtIDLPMsPRTLDSL
P41091 T109 Sugiyama EIF2S3 EIF2G YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P49840 S278 iPTMNet|EPSD GSK3A VLKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYT
P49840 S282 Sugiyama GSK3A CDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTSSID
P49840 Y279 SIGNOR|iPTMNet|EPSD|PSP|Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 S219 Sugiyama GSK3B CDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTSSID
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P52565 T160 Sugiyama ARHGDIA GDIA1 DKtDyMVGsYGPRAEEyEFLtPVEEAPKGMLARGsYsIKSR
P52565 Y156 Sugiyama ARHGDIA GDIA1 GVKIDKtDyMVGsYGPRAEEyEFLtPVEEAPKGMLARGsYs
P52630 S381 SIGNOR|PSP STAT2 VSIDRNPPQLQGFRKFNILTsNQKtLtPEKGQsQGLIWDFG
P52630 S393 SIGNOR|PSP STAT2 FRKFNILTsNQKtLtPEKGQsQGLIWDFGYLtLVEQRSGGS
P52630 T385 SIGNOR|PSP STAT2 RNPPQLQGFRKFNILTsNQKtLtPEKGQsQGLIWDFGYLtL
P53396 S451 ELM ACLY AAHTANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAK
P53396 T447 ELM ACLY QPPTAAHTANFLLNAsGststPAPsRtAsFsEsRADEVAPA
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P55809 S509 Sugiyama OXCT1 OXCT SCOT LWEGLTVDDVQKSTGCDFAVsPKLMPMQQIAN_________
P61981 S38 Sugiyama YWHAG ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62942 S9 Sugiyama FKBP1A FKBP1 FKBP12 ____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
Q00613 S303 GPS6|ELM|iPTMNet|EPSD HSF1 HSTF1 SIDERPLSSsPLVRVKEEPPsPPQsPRVEEAsPGRPssVDt
Q04206 T254 SIGNOR RELA NFKB3 EARGsFSQADVHRQVAIVFRtPPYADPsLQAPVRVsMQLRR
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07817 S62 EPSD|PSP BCL2L1 BCL2L BCLX ESEMEtPsAINGNPSWHLADsPAVNGATGHSSSLDAREVIP
Q07820 S159 SIGNOR|iPTMNet|EPSD MCL1 BCL2L3 AVLPLLELVGEsGNNtstDGsLPstPPPAEEEEDELYRQSL
Q07820 T163 iPTMNet|EPSD MCL1 BCL2L3 LLELVGEsGNNtstDGsLPstPPPAEEEEDELYRQSLEIIS
Q07869 S280 SIGNOR|PSP PPARA NR1C1 PPAR ANGIQNKEAEVRIFHCCQCTsVETVTELTEFAKAIPGFANL
Q12931 S568 Sugiyama TRAP1 HSP75 HSPC5 ISVETDIVVDHYKEEKFEDRsPAAECLSEKETEELMAWMRN
Q13131 T490 PSP PRKAA1 AMPK1 YLLDFRsIDDEItEAKsGtAtPQRsGsVsNYRSCQRsDsDA
Q13144 S535 ELM EIF2B5 EIF2BE WGLKINMEEEsEsESEQSMDsEEPDsRGGsPQMDDIKVFQN
Q13144 S540 SIGNOR|iPTMNet|EPSD EIF2B5 EIF2BE NMEEEsEsESEQSMDsEEPDsRGGsPQMDDIKVFQNEVLGT
Q13144 S544 iPTMNet|EPSD EIF2B5 EIF2BE EsEsESEQSMDsEEPDsRGGsPQMDDIKVFQNEVLGTLQRG
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13563 S76 SIGNOR|EPSD|PSP PKD2 TRPP1 TRPP2 MQRIRQAAARDPPAGAAAsPsPPLsSCSRQAWSRDNPGFEA
Q13610 S57 Sugiyama PWP1 AEAKEKLQEEGGGsDEEEtGsPsEDGMQsARTQARPREPLE
Q14449 S358 SIGNOR|PSP GRB14 RLLKYGMQLYQNYMHPYQGRsGCSsQSIsPMRsIsENSLVA
Q14449 S362 SIGNOR|PSP GRB14 YGMQLYQNYMHPYQGRsGCSsQSIsPMRsIsENSLVAMDFS
Q14449 S366 SIGNOR|PSP GRB14 LYQNYMHPYQGRsGCSsQSIsPMRsIsENSLVAMDFSGQKS
Q14449 S419 PSP GRB14 AVEEGLAWRKKGCLRLGTHGsPtAsSQSSATNMAIHRSQPW
Q14449 S423 PSP GRB14 GLAWRKKGCLRLGTHGsPtAsSQSSATNMAIHRSQPWFHHK
Q14596 T586 SIGNOR|PSP NBR1 1A13B KIAA0049 M17S2 MIG19 LDINIVQELERVPHNtPVDVtPCMsPLPHDsPLIEKPGLGQ
Q14653 S123 PSP IRF3 PHKIYEFVNSGVGDFSQPDTsPDTNGGGSTSDtQEDILDEL
Q14653 S173 PSP IRF3 PDPGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLK
Q14653 T180 PSP IRF3 LAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLKRLLVPGE
Q14980 S861 Sugiyama NUMA1 NMP22 NUMA ECEKARQELQEAKEKVAGIEsHsELQISRQQNELAELHANL
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15642 S298 Sugiyama TRIP10 CIP4 STOT STP RPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRT
Q15642 S299 Sugiyama TRIP10 CIP4 STOT STP PGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTK
Q15642 S304 Sugiyama TRIP10 CIP4 STOT STP FEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWPFG
Q15746 S16 ELM MYLK MLCK MLCK1 MYLK1 _____MGDVKLVASSHIsKTsLsVDPSRVDSMPLTEAPAFI
Q16555 S518 EPSD|PSP DPYSL2 CRMP2 ULIP2 LyDGPVCEVsVtPKtVtPAssAKtsPAKQQAPPVRNLHQsG
Q16584 S789 EPSD MAP3K11 MLK3 PTK1 SPRK PsPLRSRIDPWsFVSAGPRPsPLPsPQPAPRRAPWTLFPDS
Q16584 S793 EPSD MAP3K11 MLK3 PTK1 SPRK RSRIDPWsFVSAGPRPsPLPsPQPAPRRAPWTLFPDSDPFW
Q2M1Z3 T789 SIGNOR ARHGAP31 CDGAP KIAA1204 VEVGGPGNLsPPLPPAPPPPtPLEESTPVLLSKGGPEREDS
Q5T4S7 S178 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 AKLPQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLT
Q6R327 T1695 SIGNOR|EPSD|PSP RICTOR KIAA1999 ELFQDVQFLQMHEEAEAVLAtPPKQPIVDTSAEs_______
Q8NHW3 S49 SIGNOR|PSP MAFA FEVKKEPPEAERFCHRLPPGsLSStPLStPCSsVPSsPSFC
Q8NHW3 S61 SIGNOR|PSP MAFA FCHRLPPGsLSStPLStPCSsVPSsPSFCAPSPGTGGGGGA
Q8NHW3 T53 SIGNOR|PSP MAFA KEPPEAERFCHRLPPGsLSStPLStPCSsVPSsPSFCAPSP
Q8NHW3 T57 SIGNOR|PSP MAFA EAERFCHRLPPGsLSStPLStPCSsVPSsPSFCAPSPGTGG
Q8WXI9 S122 Sugiyama GATAD2B KIAA1150 DEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSsRM
Q8WXI9 S135 Sugiyama GATAD2B KIAA1150 ERGRLtPsPDIIVLsDNEAssPRsSsRMEERLKAANLEMFK
Q92597 S342 EPSD|PSP NDRG1 CAP43 DRG1 RTP RLMRsRtAsGssVtsLDGtRsRsHtSEGTRsRsHtsEGtRs
Q92597 S352 EPSD|PSP NDRG1 CAP43 DRG1 RTP ssVtsLDGtRsRsHtSEGTRsRsHtsEGtRsRsHtsEGAHL
Q92597 S362 PSP NDRG1 CAP43 DRG1 RTP sRsHtSEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAG
Q92908 S37 SIGNOR GATA6 AGADASDSRAFPAREPSTPPsPISSSSSSCSRGGERGPGGA
Q969R2 S762 PSP OSBP2 KIAA1664 ORP4 OSBPL4 AHYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSA
Q969R2 S763 PSP OSBP2 KIAA1664 ORP4 OSBPL4 HYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAK
Q969R2 S766 PSP OSBP2 KIAA1664 ORP4 OSBPL4 LSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLW
Q969R2 S768 PSP OSBP2 KIAA1664 ORP4 OSBPL4 GSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLWKK
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96F46 T780 SIGNOR|EPSD|PSP IL17RA IL17R LSCQAQGGCSRPAMVLTDPHtPYEEEQRQSVQsDQGyIsRs
Q96IG2 S139 PSP FBXL20 FBL2 IEVLNLNGCTKTTDATCTSLsKFCsKLRHLDLASCTSITNM
Q96IG2 S143 PSP FBXL20 FBL2 NLNGCTKTTDATCTSLsKFCsKLRHLDLASCTSITNMSLKA
Q96IG2 S251 PSP FBXL20 FBL2 CLQITDEGLITICRGCHKLQsLCAsGCSNITDAILNALGQN
Q96IG2 S255 PSP FBXL20 FBL2 TDEGLITICRGCHKLQsLCAsGCSNITDAILNALGQNCPRL
Q96IG2 S421 PSP FBXL20 FBL2 RTHLPNIKVHAyFAPVtPPPsVGGsRQRFCRCCIIL_____
Q96IG2 S425 PSP FBXL20 FBL2 PNIKVHAyFAPVtPPPsVGGsRQRFCRCCIIL_________
Q96IG2 T417 PSP FBXL20 FBL2 IKRLRTHLPNIKVHAyFAPVtPPPsVGGsRQRFCRCCIIL_
Q96K76 S910 Sugiyama USP47 DGDNGDssKstEtsDFENIEsPLNERDsSAsVDNRELEQHI
Q96RR4 S129 SIGNOR CAMKK2 CAMKKB KIAA0787 LAAGGsLDMNGRCICPsLPysPVssPQssPRLPRRPTVESH
Q96RR4 S133 SIGNOR CAMKK2 CAMKKB KIAA0787 GsLDMNGRCICPsLPysPVssPQssPRLPRRPTVESHHVSI
Q96RR4 S137 SIGNOR CAMKK2 CAMKKB KIAA0787 MNGRCICPsLPysPVssPQssPRLPRRPTVESHHVSITGMQ
Q9BYG3 S230 GPS6|ELM|EPSD|PSP NIFK MKI67IP NOPP34 LRKKKKKVsGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVA
Q9BYG3 T234 GPS6|SIGNOR|ELM|EPSD|PSP NIFK MKI67IP NOPP34 KKKVsGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELND
Q9NY33 S242 Sugiyama DPP3 SEPsLDsEVTSKLKSYEFRGsPFQVTRGDyAPILQKVVEQL
Q9NZ72 S60 SIGNOR|EPSD|PSP STMN3 SCLIP MEVKQLDKRAsGQsFEVILKsPSDLsPEsPMLssPPKKKDt
Q9NZN8 S242 Sugiyama CNOT2 CDC36 NOT2 HSPC131 MSTP046 VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9NZN8 T246 Sugiyama CNOT2 CDC36 NOT2 HSPC131 MSTP046 DLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMVTKPA
Q9NZQ7 S279 SIGNOR|PSP CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1 FRLRKGRMMDVKKCGIQDtNsKKQsDtHLEEt_________
Q9NZQ7 S283 PSP CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1 KGRMMDVKKCGIQDtNsKKQsDtHLEEt_____________
Q9UHI6 T705 Sugiyama DDX20 DP103 GEMIN3 sEstPVDDRIsLEQPPNGsDtPNPEKyQEsPGIQMKTRLKE
Q9UKT9 S378 PSP IKZF3 ZNFN1A3 ELEKKSIHLPEKSVPSERGLsPNNsGHDstDtDsNHEERQN
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y4H4 S35 SIGNOR|PSP GPSM3 AGS4 C6orf9 G18 GPPQDEEGWPPPNSTTRPWRsAPPsPPPPGTRHTALGPRsA
Q9Y6Q9 S505 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 RNRGSPKIASHQFSPVAGVHsPMAsSGNTGNHSFSSSSLSA
Q9Y6Q9 S509 SIGNOR|PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 SPKIASHQFSPVAGVHsPMAsSGNTGNHSFSSSSLSALQAI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.059559e-09 8.975 0 0
Chromatin organization R-HSA-4839726 9.106929e-10 9.041 0 0
Cell Cycle, Mitotic R-HSA-69278 1.336205e-09 8.874 0 0
Chromatin modifying enzymes R-HSA-3247509 1.149253e-08 7.940 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.070747e-07 6.513 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.475939e-06 5.459 0 0
M Phase R-HSA-68886 5.011639e-06 5.300 0 0
Signal Transduction R-HSA-162582 5.115657e-06 5.291 1 0
Mitotic Spindle Checkpoint R-HSA-69618 2.984938e-05 4.525 0 0
Mitotic Prometaphase R-HSA-68877 4.434550e-05 4.353 0 0
Cellular response to heat stress R-HSA-3371556 4.824212e-05 4.317 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.402870e-05 4.194 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.313040e-05 4.200 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.161101e-05 4.145 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.494524e-05 4.125 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.540792e-05 4.069 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.023650e-04 3.990 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.058791e-04 3.975 0 0
Apoptotic execution phase R-HSA-75153 1.037320e-04 3.984 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.328570e-04 3.877 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.266462e-04 3.897 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.266462e-04 3.897 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.230398e-04 3.910 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.611530e-04 3.793 0 0
Mitotic Anaphase R-HSA-68882 1.651510e-04 3.782 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.703300e-04 3.769 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.822685e-04 3.739 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.165175e-04 3.665 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.510081e-04 3.600 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.555959e-04 3.592 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.736315e-04 3.563 0 0
Cell Cycle Checkpoints R-HSA-69620 2.840336e-04 3.547 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.038836e-04 3.517 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.365445e-04 3.473 0 0
Nuclear import of Rev protein R-HSA-180746 3.554806e-04 3.449 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.972612e-04 3.401 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.972612e-04 3.401 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.866113e-04 3.413 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.346509e-04 3.362 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.543587e-04 3.343 0 0
Formation of definitive endoderm R-HSA-9823730 4.805323e-04 3.318 0 0
Separation of Sister Chromatids R-HSA-2467813 5.015445e-04 3.300 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.982374e-04 3.303 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.297978e-04 3.201 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.589384e-04 3.181 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.589384e-04 3.181 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.240554e-04 3.140 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.240554e-04 3.140 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.252863e-04 3.083 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.252863e-04 3.083 0 0
TGFBR3 expression R-HSA-9839394 8.252863e-04 3.083 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.691229e-04 3.114 0 0
Signaling by RAS mutants R-HSA-6802949 7.963787e-04 3.099 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.963787e-04 3.099 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.963787e-04 3.099 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.963787e-04 3.099 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.369321e-04 3.077 0 0
Cellular Senescence R-HSA-2559583 8.386730e-04 3.076 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.034232e-04 3.044 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.817949e-04 3.055 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.194217e-04 3.036 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.568040e-04 3.019 0 0
Deubiquitination R-HSA-5688426 1.033388e-03 2.986 0 0
mTORC1-mediated signalling R-HSA-166208 1.189289e-03 2.925 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.316121e-03 2.881 0 0
HATs acetylate histones R-HSA-3214847 1.313226e-03 2.882 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.376385e-03 2.861 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.712796e-03 2.766 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.631531e-03 2.787 0 0
Gene expression (Transcription) R-HSA-74160 1.775095e-03 2.751 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.032080e-03 2.692 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.032080e-03 2.692 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.032080e-03 2.692 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.025974e-03 2.693 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.921010e-03 2.716 0 0
Membrane Trafficking R-HSA-199991 2.018604e-03 2.695 0 0
S Phase R-HSA-69242 1.985291e-03 2.702 0 0
Regulation of TP53 Activity R-HSA-5633007 1.980806e-03 2.703 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.063554e-03 2.685 0 0
MTOR signalling R-HSA-165159 2.463185e-03 2.609 0 0
Signaling by Hippo R-HSA-2028269 2.463517e-03 2.608 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.477373e-03 2.606 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.559002e-03 2.592 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.688810e-03 2.570 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.970896e-03 2.527 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.014227e-03 2.521 0 0
snRNP Assembly R-HSA-191859 3.137668e-03 2.503 0 0
Metabolism of non-coding RNA R-HSA-194441 3.137668e-03 2.503 0 0
Cell-Cell communication R-HSA-1500931 3.264733e-03 2.486 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.422673e-03 2.466 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.485451e-03 2.458 0 0
Cell junction organization R-HSA-446728 3.475435e-03 2.459 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.523732e-03 2.453 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.705682e-03 2.431 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.167812e-03 2.380 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.986851e-03 2.399 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.986851e-03 2.399 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.179867e-03 2.379 0 0
PTEN Regulation R-HSA-6807070 4.272020e-03 2.369 0 0
G0 and Early G1 R-HSA-1538133 4.285891e-03 2.368 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.287303e-03 2.368 0 0
NRAGE signals death through JNK R-HSA-193648 4.478010e-03 2.349 0 0
Repression of WNT target genes R-HSA-4641265 5.046047e-03 2.297 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.788513e-03 2.320 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.833926e-03 2.316 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.932300e-03 2.307 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.071382e-03 2.295 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.211465e-03 2.283 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.211465e-03 2.283 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.227258e-03 2.282 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.326176e-03 2.199 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.480051e-03 2.188 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.926575e-03 2.159 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.926575e-03 2.159 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.926575e-03 2.159 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.010026e-03 2.154 0 0
Signaling by ALK in cancer R-HSA-9700206 7.010026e-03 2.154 0 0
ESR-mediated signaling R-HSA-8939211 7.139569e-03 2.146 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.400657e-03 2.131 0 0
RAF activation R-HSA-5673000 7.599996e-03 2.119 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.663869e-03 2.116 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.697047e-03 2.114 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 7.824305e-03 2.107 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.546784e-03 2.068 0 0
MAP kinase activation R-HSA-450294 9.031329e-03 2.044 0 0
G alpha (12/13) signalling events R-HSA-416482 8.948661e-03 2.048 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.256572e-03 2.034 0 0
Mitotic Prophase R-HSA-68875 9.269575e-03 2.033 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.756599e-03 2.011 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.901892e-03 2.004 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.073671e-02 1.969 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.025963e-02 1.989 0 0
Death Receptor Signaling R-HSA-73887 9.890575e-03 2.005 0 0
Inositol phosphate metabolism R-HSA-1483249 1.135176e-02 1.945 0 0
MAP2K and MAPK activation R-HSA-5674135 1.197907e-02 1.922 0 0
Axon guidance R-HSA-422475 1.279447e-02 1.893 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.312977e-02 1.882 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.312977e-02 1.882 0 0
Cardiogenesis R-HSA-9733709 1.321847e-02 1.879 0 0
Interleukin-17 signaling R-HSA-448424 1.354933e-02 1.868 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.367673e-02 1.864 1 1
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.401051e-02 1.854 0 0
Formation of annular gap junctions R-HSA-196025 1.439474e-02 1.842 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.451706e-02 1.838 1 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.519843e-02 1.818 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.567062e-02 1.805 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.626922e-02 1.789 0 0
mRNA Splicing R-HSA-72172 1.625260e-02 1.789 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.626922e-02 1.789 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.652592e-02 1.782 0 0
Deadenylation of mRNA R-HSA-429947 1.663196e-02 1.779 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.669731e-02 1.777 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.686244e-02 1.773 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.686244e-02 1.773 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.692264e-02 1.772 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.719411e-02 1.765 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.719411e-02 1.765 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.723509e-02 1.764 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.810370e-02 1.742 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.982232e-02 1.703 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.982232e-02 1.703 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.859174e-02 1.731 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.931034e-02 1.714 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.864476e-02 1.729 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.892350e-02 1.723 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.925738e-02 1.715 0 0
HIV Life Cycle R-HSA-162587 1.990259e-02 1.701 0 0
RNA Polymerase II Transcription R-HSA-73857 1.871965e-02 1.728 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.834222e-02 1.737 0 0
Gap junction degradation R-HSA-190873 2.008365e-02 1.697 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.008365e-02 1.697 0 0
ALK mutants bind TKIs R-HSA-9700645 2.008365e-02 1.697 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.029857e-02 1.693 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.029857e-02 1.693 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.030138e-02 1.692 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.030138e-02 1.692 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.060038e-02 1.686 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.110452e-02 1.676 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.296464e-02 1.639 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.296464e-02 1.639 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.306389e-02 1.637 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.306389e-02 1.637 0 0
Semaphorin interactions R-HSA-373755 2.306389e-02 1.637 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.346500e-02 1.630 0 0
Nervous system development R-HSA-9675108 2.365524e-02 1.626 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.707237e-02 1.567 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.468578e-02 1.608 0 0
Ub-specific processing proteases R-HSA-5689880 2.600271e-02 1.585 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.707237e-02 1.567 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.585093e-02 1.588 0 0
Signaling by NOTCH1 R-HSA-1980143 2.580685e-02 1.588 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.707237e-02 1.567 0 0
Signaling by TGFBR3 R-HSA-9839373 2.411719e-02 1.618 0 0
Specification of primordial germ cells R-HSA-9827857 2.468578e-02 1.608 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.532142e-02 1.597 0 0
Recycling pathway of L1 R-HSA-437239 2.736435e-02 1.563 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.754106e-02 1.560 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.754106e-02 1.560 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.754106e-02 1.560 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.754106e-02 1.560 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.754106e-02 1.560 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.948063e-02 1.530 0 0
CREB phosphorylation R-HSA-199920 2.948063e-02 1.530 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.091502e-02 1.510 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.099916e-02 1.509 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.134836e-02 1.504 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.164293e-02 1.500 0 0
Glycolysis R-HSA-70171 3.178372e-02 1.498 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.209803e-02 1.494 0 0
Striated Muscle Contraction R-HSA-390522 3.569072e-02 1.447 0 0
DNA Damage Bypass R-HSA-73893 3.479941e-02 1.458 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.487459e-02 1.457 0 0
Rap1 signalling R-HSA-392517 3.673590e-02 1.435 0 0
G2/M Transition R-HSA-69275 3.829320e-02 1.417 0 0
Adherens junctions interactions R-HSA-418990 3.694481e-02 1.432 0 0
Host Interactions of HIV factors R-HSA-162909 3.561786e-02 1.448 0 0
Signaling by TGFB family members R-HSA-9006936 3.744699e-02 1.427 0 0
Heme signaling R-HSA-9707616 3.913191e-02 1.407 0 0
tRNA processing in the nucleus R-HSA-6784531 3.913191e-02 1.407 0 0
HIV Infection R-HSA-162906 4.150952e-02 1.382 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.199090e-02 1.377 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.263733e-02 1.370 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.263733e-02 1.370 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.263733e-02 1.370 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.323861e-02 1.364 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.399994e-02 1.357 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.470305e-02 1.350 0 0
Activation of the pre-replicative complex R-HSA-68962 4.470305e-02 1.350 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.470305e-02 1.350 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.524366e-02 1.344 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.550459e-02 1.342 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.550459e-02 1.342 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.558814e-02 1.341 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.691215e-02 1.329 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.722055e-02 1.326 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.850440e-02 1.314 0 0
mRNA 3'-end processing R-HSA-72187 4.850485e-02 1.314 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 5.704668e-02 1.244 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 5.704668e-02 1.244 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 5.704668e-02 1.244 0 0
Type I hemidesmosome assembly R-HSA-446107 5.416758e-02 1.266 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.651030e-02 1.248 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.651030e-02 1.248 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.511648e-02 1.259 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.621713e-02 1.250 0 0
Nucleotide Excision Repair R-HSA-5696398 5.064495e-02 1.295 0 0
Adrenoceptors R-HSA-390696 5.416758e-02 1.266 0 0
Signaling by ERBB2 R-HSA-1227986 5.856015e-02 1.232 0 0
Synthesis of DNA R-HSA-69239 5.842482e-02 1.233 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.704668e-02 1.244 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.856015e-02 1.232 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.856015e-02 1.232 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.856015e-02 1.232 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.856015e-02 1.232 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.742083e-02 1.241 0 0
Cell-cell junction organization R-HSA-421270 4.922578e-02 1.308 0 0
Generic Transcription Pathway R-HSA-212436 5.543767e-02 1.256 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.416758e-02 1.266 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.856015e-02 1.232 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.511648e-02 1.259 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.008775e-02 1.221 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.061951e-02 1.217 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.061951e-02 1.217 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.114312e-02 1.214 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.114312e-02 1.214 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.116856e-02 1.213 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.179187e-02 1.209 0 0
IRS activation R-HSA-74713 6.179187e-02 1.209 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.179187e-02 1.209 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.179187e-02 1.209 0 0
G1/S Transition R-HSA-69206 6.339635e-02 1.198 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.425630e-02 1.192 0 0
Signaling by NOTCH3 R-HSA-9012852 6.554310e-02 1.183 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.651357e-02 1.177 0 0
Nuclear RNA decay R-HSA-9930044 6.652403e-02 1.177 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.747891e-02 1.171 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.800987e-02 1.167 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.924531e-02 1.160 0 0
Formation of axial mesoderm R-HSA-9796292 6.924531e-02 1.160 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.966967e-02 1.157 0 0
Calcineurin activates NFAT R-HSA-2025928 6.966967e-02 1.157 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 6.966967e-02 1.157 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.423846e-02 1.074 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.423846e-02 1.074 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 8.342993e-02 1.079 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.342993e-02 1.079 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.751876e-02 1.111 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.751876e-02 1.111 0 0
Notch-HLH transcription pathway R-HSA-350054 7.105288e-02 1.148 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.381068e-02 1.077 0 0
Dual Incision in GG-NER R-HSA-5696400 8.424170e-02 1.074 0 0
HSF1-dependent transactivation R-HSA-3371571 8.080969e-02 1.093 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.200327e-02 1.143 0 0
Centrosome maturation R-HSA-380287 7.216412e-02 1.142 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.439803e-02 1.074 0 0
Signaling by EGFR R-HSA-177929 7.200327e-02 1.143 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.019198e-02 1.096 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.751876e-02 1.111 0 0
Regulation of CDH11 function R-HSA-9762292 8.719288e-02 1.060 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.368201e-02 1.077 0 0
Rab regulation of trafficking R-HSA-9007101 8.303073e-02 1.081 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.525301e-02 1.069 0 0
Post NMDA receptor activation events R-HSA-438064 7.275066e-02 1.138 0 0
Signaling by WNT R-HSA-195721 8.246296e-02 1.084 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.031101e-02 1.153 0 0
Regulation of CDH1 Function R-HSA-9764561 7.886372e-02 1.103 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.381068e-02 1.077 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.618851e-02 1.118 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.506163e-02 1.125 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.247708e-02 1.140 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.247708e-02 1.140 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.247708e-02 1.140 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.886372e-02 1.103 0 0
Apoptosis R-HSA-109581 8.967251e-02 1.047 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.038448e-02 1.044 0 0
Gastrulation R-HSA-9758941 9.317826e-02 1.031 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.345126e-02 1.029 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.345126e-02 1.029 0 0
Regulation of cortical dendrite branching R-HSA-8985801 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.345126e-02 1.029 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.345126e-02 1.029 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.345126e-02 1.029 0 0
Regulation of TP53 Expression R-HSA-6804754 9.345126e-02 1.029 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.356324e-02 1.029 0 0
Neurodegenerative Diseases R-HSA-8863678 9.356324e-02 1.029 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 9.356324e-02 1.029 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.450586e-02 1.025 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.456206e-02 1.024 0 0
Signaling by VEGF R-HSA-194138 9.478147e-02 1.023 0 0
Adipogenesis R-HSA-9843745 9.582750e-02 1.019 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.685023e-02 1.014 0 0
DCC mediated attractive signaling R-HSA-418885 9.902394e-02 1.004 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.902394e-02 1.004 0 0
Circadian clock R-HSA-9909396 1.012096e-01 0.995 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.198668e-01 0.921 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.198668e-01 0.921 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.198668e-01 0.921 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.198668e-01 0.921 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.198668e-01 0.921 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.198668e-01 0.921 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.198668e-01 0.921 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.198668e-01 0.921 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.198668e-01 0.921 0 0
MET interacts with TNS proteins R-HSA-8875513 1.346785e-01 0.871 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.346785e-01 0.871 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.346785e-01 0.871 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.346785e-01 0.871 0 0
Activation of RAC1 R-HSA-428540 1.278159e-01 0.893 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.278159e-01 0.893 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.278159e-01 0.893 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.278159e-01 0.893 0 0
Phosphorylation of the APC/C R-HSA-176412 1.159680e-01 0.936 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.043334e-01 0.982 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.341860e-01 0.872 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.353332e-01 0.869 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.338588e-01 0.873 0 0
G1/S-Specific Transcription R-HSA-69205 1.045262e-01 0.981 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.309798e-01 0.883 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.228496e-01 0.911 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.353332e-01 0.869 0 0
Homology Directed Repair R-HSA-5693538 1.295512e-01 0.888 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.066233e-01 0.972 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.195864e-01 0.922 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.096173e-01 0.960 0 0
Long-term potentiation R-HSA-9620244 1.061452e-01 0.974 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.338588e-01 0.873 0 0
L1CAM interactions R-HSA-373760 1.162046e-01 0.935 0 0
MAPK family signaling cascades R-HSA-5683057 1.304675e-01 0.884 0 0
DNA Repair R-HSA-73894 1.244180e-01 0.905 0 0
Calmodulin induced events R-HSA-111933 1.045262e-01 0.981 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.195864e-01 0.922 0 0
HDACs deacetylate histones R-HSA-3214815 1.146806e-01 0.941 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.018767e-01 0.992 0 0
HDMs demethylate histones R-HSA-3214842 1.061452e-01 0.974 0 0
CaM pathway R-HSA-111997 1.045262e-01 0.981 0 0
Cellular responses to stress R-HSA-2262752 1.252780e-01 0.902 1 0
Ovarian tumor domain proteases R-HSA-5689896 1.156191e-01 0.937 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.338588e-01 0.873 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.091324e-01 0.962 0 0
Metabolism of RNA R-HSA-8953854 1.161889e-01 0.935 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.346785e-01 0.871 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.278159e-01 0.893 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.159680e-01 0.936 0 0
TBC/RABGAPs R-HSA-8854214 1.232717e-01 0.909 0 0
Gene Silencing by RNA R-HSA-211000 1.350288e-01 0.870 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.309798e-01 0.883 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.143759e-01 0.942 0 0
Inhibition of nitric oxide production R-HSA-9636249 1.346785e-01 0.871 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.309798e-01 0.883 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.066233e-01 0.972 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.087542e-01 0.964 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.159680e-01 0.936 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.353332e-01 0.869 0 0
Glucose metabolism R-HSA-70326 1.227680e-01 0.911 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.375231e-01 0.862 0 0
Regulation of PTEN localization R-HSA-8948747 1.375231e-01 0.862 0 0
SOS-mediated signalling R-HSA-112412 1.375231e-01 0.862 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.375231e-01 0.862 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.375231e-01 0.862 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.396483e-01 0.855 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.413925e-01 0.850 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.413925e-01 0.850 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.413925e-01 0.850 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.426265e-01 0.846 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.442182e-01 0.841 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.459770e-01 0.836 0 0
DAG and IP3 signaling R-HSA-1489509 1.463305e-01 0.835 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.488316e-01 0.827 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.504630e-01 0.823 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.506025e-01 0.822 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.506025e-01 0.822 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.506025e-01 0.822 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.506025e-01 0.822 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.506025e-01 0.822 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.506025e-01 0.822 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.506025e-01 0.822 0 0
OAS antiviral response R-HSA-8983711 1.506025e-01 0.822 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.509293e-01 0.821 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.511144e-01 0.821 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.515240e-01 0.820 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.522852e-01 0.817 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.535881e-01 0.814 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.555758e-01 0.808 0 0
Regulation of beta-cell development R-HSA-186712 1.555758e-01 0.808 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.586327e-01 0.800 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.253717e-01 0.647 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.253717e-01 0.647 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.253717e-01 0.647 0 0
Regulation of gap junction activity R-HSA-191650 1.790505e-01 0.747 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.790505e-01 0.747 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.790505e-01 0.747 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.790505e-01 0.747 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.252218e-01 0.647 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.252218e-01 0.647 0 0
G2 Phase R-HSA-68911 2.252218e-01 0.647 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.252218e-01 0.647 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.675315e-01 0.776 0 0
RSK activation R-HSA-444257 1.675315e-01 0.776 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.675315e-01 0.776 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.675315e-01 0.776 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.675315e-01 0.776 0 0
WNT mediated activation of DVL R-HSA-201688 1.992181e-01 0.701 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.747983e-01 0.757 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.321723e-01 0.634 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.002084e-01 0.699 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.740728e-01 0.759 0 0
Ephrin signaling R-HSA-3928664 1.740728e-01 0.759 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.740728e-01 0.759 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.266330e-01 0.645 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.266330e-01 0.645 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.266330e-01 0.645 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.955302e-01 0.709 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.955302e-01 0.709 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.647531e-01 0.783 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.887842e-01 0.724 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.178440e-01 0.662 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.178440e-01 0.662 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.178440e-01 0.662 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.178440e-01 0.662 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.162863e-01 0.665 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.714264e-01 0.766 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.632826e-01 0.787 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.632826e-01 0.787 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.632826e-01 0.787 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.668413e-01 0.778 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.880923e-01 0.726 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.011070e-01 0.697 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.807259e-01 0.743 0 0
Nucleosome assembly R-HSA-774815 2.408120e-01 0.618 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.408120e-01 0.618 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.823257e-01 0.739 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.644683e-01 0.784 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.282530e-01 0.642 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.282530e-01 0.642 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.276025e-01 0.643 0 0
EPH-Ephrin signaling R-HSA-2682334 1.654922e-01 0.781 0 0
G1 Phase R-HSA-69236 2.249618e-01 0.648 0 0
Cyclin D associated events in G1 R-HSA-69231 2.249618e-01 0.648 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.249618e-01 0.648 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.287327e-01 0.641 0 0
Polo-like kinase mediated events R-HSA-156711 1.740728e-01 0.759 0 0
EGFR downregulation R-HSA-182971 1.984845e-01 0.702 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.162863e-01 0.665 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.040968e-01 0.690 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.992181e-01 0.701 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.346368e-01 0.630 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.148877e-01 0.668 0 0
Myogenesis R-HSA-525793 2.282579e-01 0.642 0 0
Signaling by WNT in cancer R-HSA-4791275 2.162863e-01 0.665 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.754778e-01 0.756 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.287327e-01 0.641 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.814862e-01 0.741 0 0
Ca2+ pathway R-HSA-4086398 1.611832e-01 0.793 0 0
TNF signaling R-HSA-75893 2.011070e-01 0.697 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.252218e-01 0.647 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.408939e-01 0.618 0 0
DNA strand elongation R-HSA-69190 2.162863e-01 0.665 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.945313e-01 0.711 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.346368e-01 0.630 0 0
Signaling by ROBO receptors R-HSA-376176 1.640773e-01 0.785 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.800185e-01 0.745 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.923560e-01 0.716 0 0
Kinesins R-HSA-983189 1.668413e-01 0.778 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.887842e-01 0.724 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.923560e-01 0.716 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.196732e-01 0.658 0 0
Cilium Assembly R-HSA-5617833 2.242479e-01 0.649 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.196732e-01 0.658 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.721678e-01 0.764 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.321723e-01 0.634 0 0
Vesicle-mediated transport R-HSA-5653656 1.927707e-01 0.715 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.701252e-01 0.769 0 0
G2/M Checkpoints R-HSA-69481 2.089946e-01 0.680 0 0
Signal attenuation R-HSA-74749 2.321723e-01 0.634 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.992181e-01 0.701 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.955302e-01 0.709 0 0
Signaling by NOTCH R-HSA-157118 2.219628e-01 0.654 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.405161e-01 0.619 0 0
Cellular responses to stimuli R-HSA-8953897 2.051616e-01 0.688 1 0
Oncogene Induced Senescence R-HSA-2559585 1.736106e-01 0.760 0 0
Ca-dependent events R-HSA-111996 1.945313e-01 0.711 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.029360e-01 0.693 0 0
Signaling by PTK6 R-HSA-8848021 2.029360e-01 0.693 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.039337e-01 0.691 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.253717e-01 0.647 0 0
Unwinding of DNA R-HSA-176974 1.992181e-01 0.701 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.945421e-01 0.711 0 0
RUNX2 regulates bone development R-HSA-8941326 1.890525e-01 0.723 0 0
PI Metabolism R-HSA-1483255 2.039337e-01 0.691 0 0
ERK/MAPK targets R-HSA-198753 2.408939e-01 0.618 0 0
Programmed Cell Death R-HSA-5357801 1.831266e-01 0.737 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.675315e-01 0.776 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.841263e-01 0.735 0 0
Signaling by NTRKs R-HSA-166520 1.721678e-01 0.764 0 0
Interferon Signaling R-HSA-913531 1.642115e-01 0.785 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.647531e-01 0.783 0 0
Sensory processing of sound R-HSA-9659379 2.283206e-01 0.641 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.266330e-01 0.645 0 0
Interleukin-37 signaling R-HSA-9008059 1.812888e-01 0.742 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.992181e-01 0.701 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.419718e-01 0.616 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.423388e-01 0.616 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.489122e-01 0.604 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.511563e-01 0.600 1 0
Processing of DNA double-strand break ends R-HSA-5693607 2.529607e-01 0.597 0 0
Killing mechanisms R-HSA-9664420 2.538723e-01 0.595 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.538723e-01 0.595 0 0
Prolonged ERK activation events R-HSA-169893 2.538723e-01 0.595 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.538723e-01 0.595 0 0
Signaling by NOTCH4 R-HSA-9013694 2.545025e-01 0.594 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.545025e-01 0.594 0 0
DNA Double Strand Break Response R-HSA-5693606 2.557896e-01 0.592 0 0
G-protein mediated events R-HSA-112040 2.557896e-01 0.592 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.559386e-01 0.592 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.559386e-01 0.592 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.570375e-01 0.590 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.570375e-01 0.590 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.643161e-01 0.578 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.645580e-01 0.577 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.645580e-01 0.577 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.656384e-01 0.576 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.660074e-01 0.575 0 0
Signaling by APC mutants R-HSA-4839744 2.660074e-01 0.575 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.660074e-01 0.575 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.660074e-01 0.575 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.660074e-01 0.575 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.182348e-01 0.497 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.182348e-01 0.497 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.182348e-01 0.497 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.182348e-01 0.497 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.182348e-01 0.497 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.182348e-01 0.497 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.182348e-01 0.497 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.721241e-01 0.565 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.721241e-01 0.565 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.721241e-01 0.565 0 0
Phosphorylation of Emi1 R-HSA-176417 2.721241e-01 0.565 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.721241e-01 0.565 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.721241e-01 0.565 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.999701e-01 0.398 0 0
Defective visual phototransduction due to ABCA4 loss of function R-HSA-9918454 3.999701e-01 0.398 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.999701e-01 0.398 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.999701e-01 0.398 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.999701e-01 0.398 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.999701e-01 0.398 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.999701e-01 0.398 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.999701e-01 0.398 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.999701e-01 0.398 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.189193e-01 0.496 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.189193e-01 0.496 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.189193e-01 0.496 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.649595e-01 0.438 0 0
Recycling of eIF2:GDP R-HSA-72731 3.649595e-01 0.438 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.719105e-01 0.326 0 0
MET activates PTPN11 R-HSA-8865999 4.719105e-01 0.326 0 0
Invadopodia formation R-HSA-8941237 4.719105e-01 0.326 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.817303e-01 0.550 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.349256e-01 0.475 1 1
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.349256e-01 0.475 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.100181e-01 0.509 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.100181e-01 0.509 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.100181e-01 0.509 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.097533e-01 0.387 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.097533e-01 0.387 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.097533e-01 0.387 0 0
Activation of RAS in B cells R-HSA-1169092 4.097533e-01 0.387 0 0
MET receptor recycling R-HSA-8875656 4.097533e-01 0.387 0 0
HIV elongation arrest and recovery R-HSA-167287 2.700675e-01 0.569 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.700675e-01 0.569 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.693974e-01 0.433 0 0
GAB1 signalosome R-HSA-180292 3.385559e-01 0.470 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.132432e-01 0.504 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.916392e-01 0.535 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.727435e-01 0.564 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.727435e-01 0.564 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.035294e-01 0.394 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.035294e-01 0.394 0 0
Removal of the Flap Intermediate R-HSA-69166 4.035294e-01 0.394 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.529381e-01 0.344 0 0
ARMS-mediated activation R-HSA-170984 4.529381e-01 0.344 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.736009e-01 0.563 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.918228e-01 0.535 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.918228e-01 0.535 0 0
HIV Transcription Initiation R-HSA-167161 2.918228e-01 0.535 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.918228e-01 0.535 0 0
Translation initiation complex formation R-HSA-72649 2.727575e-01 0.564 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.629543e-01 0.440 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.957214e-01 0.403 0 0
Degradation of DVL R-HSA-4641258 3.324859e-01 0.478 0 0
Transcription of the HIV genome R-HSA-167172 2.697161e-01 0.569 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.697161e-01 0.569 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.371043e-01 0.359 0 0
Erythropoietin activates RAS R-HSA-9027284 4.371043e-01 0.359 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.371043e-01 0.359 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.371043e-01 0.359 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.863496e-01 0.543 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.288230e-01 0.483 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.046477e-01 0.516 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.240513e-01 0.373 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.240513e-01 0.373 0 0
2-LTR circle formation R-HSA-164843 4.942560e-01 0.306 0 0
Dual incision in TC-NER R-HSA-6782135 3.373828e-01 0.472 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.128153e-01 0.384 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.128153e-01 0.384 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.665477e-01 0.436 0 0
Orc1 removal from chromatin R-HSA-68949 3.601166e-01 0.444 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.699381e-01 0.328 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.938370e-01 0.405 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.938370e-01 0.405 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.938370e-01 0.405 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.520371e-01 0.345 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.778827e-01 0.423 0 0
FGFR2 alternative splicing R-HSA-6803529 4.795650e-01 0.319 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.795650e-01 0.319 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.018782e-01 0.299 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.552119e-01 0.342 0 0
HSF1 activation R-HSA-3371511 4.695059e-01 0.328 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.615600e-01 0.336 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.065348e-01 0.295 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.065348e-01 0.295 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.328008e-01 0.273 0 0
Downstream signal transduction R-HSA-186763 5.099912e-01 0.292 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.589340e-01 0.445 0 0
Integrin signaling R-HSA-354192 3.804282e-01 0.420 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.003663e-01 0.522 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.982710e-01 0.525 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.597637e-01 0.337 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.135433e-01 0.504 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.328008e-01 0.273 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.152117e-01 0.288 0 0
Pexophagy R-HSA-9664873 4.942560e-01 0.306 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.913061e-01 0.309 0 0
FOXO-mediated transcription R-HSA-9614085 4.343048e-01 0.362 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.817303e-01 0.550 0 0
UCH proteinases R-HSA-5689603 3.878514e-01 0.411 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.936214e-01 0.405 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.649595e-01 0.438 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.529381e-01 0.344 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.529381e-01 0.344 0 0
PI3K/AKT activation R-HSA-198203 4.942560e-01 0.306 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.699381e-01 0.328 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.018782e-01 0.299 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.385559e-01 0.470 0 0
Chromosome Maintenance R-HSA-73886 3.663923e-01 0.436 0 0
Interferon gamma signaling R-HSA-877300 4.114696e-01 0.386 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.727435e-01 0.564 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.291801e-01 0.367 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.028521e-01 0.395 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.097533e-01 0.387 0 0
Trafficking of AMPA receptors R-HSA-399719 3.356966e-01 0.474 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.804282e-01 0.420 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.897307e-01 0.538 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.881888e-01 0.311 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.737168e-01 0.563 0 0
Lagging Strand Synthesis R-HSA-69186 4.240513e-01 0.373 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.923760e-01 0.534 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.528387e-01 0.452 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.065348e-01 0.295 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.624098e-01 0.441 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.176119e-01 0.379 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.371043e-01 0.359 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.667850e-01 0.436 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.152117e-01 0.288 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.435870e-01 0.353 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.348419e-01 0.362 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.671755e-01 0.435 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.349256e-01 0.475 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 3.693974e-01 0.433 0 0
Frs2-mediated activation R-HSA-170968 3.693974e-01 0.433 0 0
p75NTR signals via NF-kB R-HSA-193639 4.371043e-01 0.359 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.879172e-01 0.411 0 0
Selective autophagy R-HSA-9663891 4.680835e-01 0.330 0 0
DNA Replication R-HSA-69306 3.485878e-01 0.458 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.035294e-01 0.394 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.918228e-01 0.535 0 0
p38MAPK events R-HSA-171007 4.371043e-01 0.359 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.328008e-01 0.273 0 0
Signalling to ERKs R-HSA-187687 2.923760e-01 0.534 0 0
Signaling by NODAL R-HSA-1181150 3.957214e-01 0.403 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.099912e-01 0.292 0 0
NGF-stimulated transcription R-HSA-9031628 2.904635e-01 0.537 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.804282e-01 0.420 0 0
Macroautophagy R-HSA-1632852 3.706610e-01 0.431 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.520371e-01 0.345 0 0
PLC beta mediated events R-HSA-112043 2.714131e-01 0.566 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.278158e-01 0.369 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.182348e-01 0.497 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.182348e-01 0.497 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.182348e-01 0.497 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.182348e-01 0.497 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.999701e-01 0.398 0 0
C6 deamination of adenosine R-HSA-75102 3.999701e-01 0.398 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.999701e-01 0.398 0 0
Signalling to ERK5 R-HSA-198765 3.999701e-01 0.398 0 0
Signaling by AXIN mutants R-HSA-4839735 3.003663e-01 0.522 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.385559e-01 0.470 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.529381e-01 0.344 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.942560e-01 0.306 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.942560e-01 0.306 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.942560e-01 0.306 0 0
Differentiation of T cells R-HSA-9945266 4.699381e-01 0.328 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.699381e-01 0.328 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.520371e-01 0.345 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.065348e-01 0.295 0 0
Signaling by MET R-HSA-6806834 4.489204e-01 0.348 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.240513e-01 0.373 0 0
Neurexins and neuroligins R-HSA-6794361 3.601166e-01 0.444 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.014928e-01 0.521 0 0
Aggrephagy R-HSA-9646399 3.938370e-01 0.405 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.438107e-01 0.353 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.700675e-01 0.569 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.740791e-01 0.427 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.288230e-01 0.483 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.018782e-01 0.299 0 0
Other semaphorin interactions R-HSA-416700 4.371043e-01 0.359 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.135667e-01 0.383 0 0
Negative regulation of MET activity R-HSA-6807004 3.957214e-01 0.403 0 0
Toll-like Receptor Cascades R-HSA-168898 5.116017e-01 0.291 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.721241e-01 0.565 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.529381e-01 0.344 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.529381e-01 0.344 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.795650e-01 0.319 0 0
Base Excision Repair R-HSA-73884 4.970631e-01 0.304 0 0
RET signaling R-HSA-8853659 3.123111e-01 0.505 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.100181e-01 0.509 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.385559e-01 0.470 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.677676e-01 0.572 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.982710e-01 0.525 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.293773e-01 0.367 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.123763e-01 0.505 0 0
Inhibition of membrane repair R-HSA-9635644 3.182348e-01 0.497 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.182348e-01 0.497 0 0
DSCAM interactions R-HSA-376172 3.999701e-01 0.398 0 0
Diseases of cellular response to stress R-HSA-9675132 3.999701e-01 0.398 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.999701e-01 0.398 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.100181e-01 0.509 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.035294e-01 0.394 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.529381e-01 0.344 0 0
Protein methylation R-HSA-8876725 4.371043e-01 0.359 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.804282e-01 0.420 0 0
Potential therapeutics for SARS R-HSA-9679191 3.180103e-01 0.498 0 0
Disorders of Developmental Biology R-HSA-9675151 5.018782e-01 0.299 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.128153e-01 0.384 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.887145e-01 0.540 0 0
Smooth Muscle Contraction R-HSA-445355 5.173420e-01 0.286 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.095925e-01 0.388 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.100181e-01 0.509 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.693974e-01 0.433 0 0
Signal regulatory protein family interactions R-HSA-391160 4.035294e-01 0.394 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.123111e-01 0.505 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.649595e-01 0.438 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.529381e-01 0.344 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.371043e-01 0.359 0 0
RMTs methylate histone arginines R-HSA-3214858 3.476190e-01 0.459 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.529381e-01 0.344 0 0
Mismatch Repair R-HSA-5358508 3.385559e-01 0.470 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.021603e-01 0.396 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.100181e-01 0.509 0 0
Interleukin-1 processing R-HSA-448706 4.529381e-01 0.344 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.385559e-01 0.470 0 0
Josephin domain DUBs R-HSA-5689877 4.942560e-01 0.306 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.319221e-01 0.479 1 1
ROBO receptors bind AKAP5 R-HSA-9010642 4.097533e-01 0.387 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.887145e-01 0.540 0 0
IRE1alpha activates chaperones R-HSA-381070 4.154302e-01 0.382 1 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.314103e-01 0.365 0 0
Signaling by Leptin R-HSA-2586552 4.942560e-01 0.306 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.328602e-01 0.273 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.335339e-01 0.273 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.335339e-01 0.273 0 0
Formation of the posterior neural plate R-HSA-9832991 5.335339e-01 0.273 0 0
Synthesis of PI R-HSA-1483226 5.335339e-01 0.273 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.335339e-01 0.273 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.335339e-01 0.273 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.339477e-01 0.273 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.346984e-01 0.272 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.346984e-01 0.272 0 0
Diseases of DNA repair R-HSA-9675135 5.346984e-01 0.272 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.352293e-01 0.271 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.352293e-01 0.271 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.352293e-01 0.271 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.352293e-01 0.271 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.352293e-01 0.271 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.352293e-01 0.271 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.352293e-01 0.271 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.352293e-01 0.271 0 0
Dopamine receptors R-HSA-390651 5.352293e-01 0.271 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.352293e-01 0.271 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.352293e-01 0.271 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.352293e-01 0.271 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.352293e-01 0.271 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.352909e-01 0.271 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.363215e-01 0.271 0 0
PCP/CE pathway R-HSA-4086400 5.380732e-01 0.269 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.414932e-01 0.266 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.423277e-01 0.266 0 0
Autophagy R-HSA-9612973 5.471177e-01 0.262 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.532067e-01 0.257 0 0
HIV Transcription Elongation R-HSA-167169 5.546950e-01 0.256 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.546950e-01 0.256 0 0
Attenuation phase R-HSA-3371568 5.546950e-01 0.256 0 0
Tight junction interactions R-HSA-420029 5.584679e-01 0.253 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.584679e-01 0.253 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.588940e-01 0.253 0 0
HCMV Early Events R-HSA-9609690 5.605053e-01 0.251 0 0
PKA activation R-HSA-163615 5.626088e-01 0.250 0 0
PKA activation in glucagon signalling R-HSA-164378 5.626088e-01 0.250 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.626088e-01 0.250 0 0
Nephron development R-HSA-9831926 5.626088e-01 0.250 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.683199e-01 0.245 0 0
Ion transport by P-type ATPases R-HSA-936837 5.698115e-01 0.244 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.706671e-01 0.244 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.706671e-01 0.244 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.706671e-01 0.244 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.706671e-01 0.244 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.706671e-01 0.244 0 0
Integration of provirus R-HSA-162592 5.706671e-01 0.244 0 0
NF-kB is activated and signals survival R-HSA-209560 5.706671e-01 0.244 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.706671e-01 0.244 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.706671e-01 0.244 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.706671e-01 0.244 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.706671e-01 0.244 0 0
Developmental Biology R-HSA-1266738 5.707708e-01 0.244 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.750053e-01 0.240 0 0
FLT3 Signaling R-HSA-9607240 5.750053e-01 0.240 0 0
MHC class II antigen presentation R-HSA-2132295 5.794361e-01 0.237 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.832970e-01 0.234 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.832970e-01 0.234 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.832970e-01 0.234 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 5.832970e-01 0.234 0 0
Reproduction R-HSA-1474165 5.907554e-01 0.229 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.909594e-01 0.228 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.909594e-01 0.228 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.909594e-01 0.228 0 0
Activation of AKT2 R-HSA-165158 5.909594e-01 0.228 0 0
Reelin signalling pathway R-HSA-8866376 5.909594e-01 0.228 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.909594e-01 0.228 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.909594e-01 0.228 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.909594e-01 0.228 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.911110e-01 0.228 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.911110e-01 0.228 0 0
Degradation of CDH1 R-HSA-9766229 5.911110e-01 0.228 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.912286e-01 0.228 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.912286e-01 0.228 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.948439e-01 0.226 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.948439e-01 0.226 0 0
Signaling by ERBB4 R-HSA-1236394 5.997249e-01 0.222 0 0
Signaling by FGFR in disease R-HSA-1226099 5.997249e-01 0.222 0 0
Signaling by NOTCH2 R-HSA-1980145 5.999596e-01 0.222 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.056052e-01 0.218 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.056052e-01 0.218 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.056052e-01 0.218 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.056052e-01 0.218 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.056052e-01 0.218 0 0
MET activates RAS signaling R-HSA-8851805 6.056052e-01 0.218 0 0
Signaling by LTK R-HSA-9842663 6.056052e-01 0.218 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.072983e-01 0.217 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.072983e-01 0.217 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.072983e-01 0.217 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.072983e-01 0.217 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.072983e-01 0.217 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.186079e-01 0.209 0 0
Signal transduction by L1 R-HSA-445144 6.186079e-01 0.209 0 0
Nephrin family interactions R-HSA-373753 6.186079e-01 0.209 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.209435e-01 0.207 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.209435e-01 0.207 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.234382e-01 0.205 0 0
Signaling by Interleukins R-HSA-449147 6.253301e-01 0.204 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.275861e-01 0.202 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.294242e-01 0.201 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.304333e-01 0.200 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.304333e-01 0.200 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.304333e-01 0.200 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.383407e-01 0.195 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.383407e-01 0.195 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.383407e-01 0.195 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.400098e-01 0.194 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.400098e-01 0.194 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.400098e-01 0.194 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.400098e-01 0.194 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.400098e-01 0.194 0 0
Signaling by MAPK mutants R-HSA-9652817 6.400098e-01 0.194 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.400098e-01 0.194 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.400098e-01 0.194 0 0
PDE3B signalling R-HSA-165160 6.400098e-01 0.194 0 0
PKB-mediated events R-HSA-109703 6.400098e-01 0.194 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.400098e-01 0.194 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.400098e-01 0.194 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.400098e-01 0.194 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.400098e-01 0.194 0 0
Meiosis R-HSA-1500620 6.400114e-01 0.194 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.412575e-01 0.193 0 0
FLT3 signaling in disease R-HSA-9682385 6.412575e-01 0.193 0 0
Muscle contraction R-HSA-397014 6.431513e-01 0.192 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.447130e-01 0.191 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.447130e-01 0.191 0 0
Signalling to RAS R-HSA-167044 6.447130e-01 0.191 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.447130e-01 0.191 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.447130e-01 0.191 0 0
Netrin-1 signaling R-HSA-373752 6.512469e-01 0.186 0 0
Amine ligand-binding receptors R-HSA-375280 6.512469e-01 0.186 0 0
Signaling by Erythropoietin R-HSA-9006335 6.526736e-01 0.185 0 0
mRNA Capping R-HSA-72086 6.526736e-01 0.185 0 0
RNA Polymerase I Transcription R-HSA-73864 6.579269e-01 0.182 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.644829e-01 0.178 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.651853e-01 0.177 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.688993e-01 0.175 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.688993e-01 0.175 0 0
Physiological factors R-HSA-5578768 6.688993e-01 0.175 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.688993e-01 0.175 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.689383e-01 0.175 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.689383e-01 0.175 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.689383e-01 0.175 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.692297e-01 0.174 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.699072e-01 0.174 0 0
Interleukin-1 signaling R-HSA-9020702 6.711674e-01 0.173 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.726747e-01 0.172 0 0
Interleukin-1 family signaling R-HSA-446652 6.729715e-01 0.172 0 0
Hedgehog 'on' state R-HSA-5632684 6.774107e-01 0.169 0 0
MET promotes cell motility R-HSA-8875878 6.797923e-01 0.168 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.798112e-01 0.168 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.831808e-01 0.165 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.831808e-01 0.165 0 0
Signaling by LTK in cancer R-HSA-9842640 6.831808e-01 0.165 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.831808e-01 0.165 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.831808e-01 0.165 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.831808e-01 0.165 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.831808e-01 0.165 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.831808e-01 0.165 0 0
Nef and signal transduction R-HSA-164944 6.831808e-01 0.165 0 0
Leukotriene receptors R-HSA-391906 6.831808e-01 0.165 0 0
Neurofascin interactions R-HSA-447043 6.831808e-01 0.165 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.851443e-01 0.164 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.930449e-01 0.159 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.973324e-01 0.157 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.973324e-01 0.157 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.973324e-01 0.157 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.973324e-01 0.157 0 0
Translesion synthesis by REV1 R-HSA-110312 6.973324e-01 0.157 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.973324e-01 0.157 0 0
Signaling by Activin R-HSA-1502540 6.973324e-01 0.157 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.973324e-01 0.157 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.973324e-01 0.157 0 0
Formation of the anterior neural plate R-HSA-9823739 6.973324e-01 0.157 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.973324e-01 0.157 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.977810e-01 0.156 1 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.979850e-01 0.156 0 0
Stabilization of p53 R-HSA-69541 6.979850e-01 0.156 0 0
Signaling by ALK R-HSA-201556 6.979850e-01 0.156 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.025690e-01 0.153 0 0
Influenza Infection R-HSA-168255 7.031919e-01 0.153 0 0
Opioid Signalling R-HSA-111885 7.061419e-01 0.151 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.061419e-01 0.151 0 0
Ion homeostasis R-HSA-5578775 7.076137e-01 0.150 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.128540e-01 0.147 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.154512e-01 0.145 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.154512e-01 0.145 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.211768e-01 0.142 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.211768e-01 0.142 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.211768e-01 0.142 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.211768e-01 0.142 0 0
Disinhibition of SNARE formation R-HSA-114516 7.211768e-01 0.142 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.211768e-01 0.142 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.211768e-01 0.142 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.211768e-01 0.142 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.211768e-01 0.142 0 0
Netrin mediated repulsion signals R-HSA-418886 7.211768e-01 0.142 0 0
PTK6 Expression R-HSA-8849473 7.211768e-01 0.142 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.211768e-01 0.142 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.211768e-01 0.142 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.211768e-01 0.142 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.211768e-01 0.142 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.211768e-01 0.142 0 0
VLDL clearance R-HSA-8964046 7.211768e-01 0.142 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.211768e-01 0.142 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.211768e-01 0.142 0 0
CHL1 interactions R-HSA-447041 7.211768e-01 0.142 0 0
Translesion synthesis by POLI R-HSA-5656121 7.237102e-01 0.140 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.237102e-01 0.140 0 0
Negative regulation of FLT3 R-HSA-9706369 7.237102e-01 0.140 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.237102e-01 0.140 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.309503e-01 0.136 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.324164e-01 0.135 0 0
G-protein beta:gamma signalling R-HSA-397795 7.324164e-01 0.135 0 0
Gap junction trafficking and regulation R-HSA-157858 7.338139e-01 0.134 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.362406e-01 0.133 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.481166e-01 0.126 0 0
Translesion synthesis by POLK R-HSA-5655862 7.481166e-01 0.126 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.481166e-01 0.126 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.481166e-01 0.126 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.481989e-01 0.126 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.500425e-01 0.125 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.500425e-01 0.125 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.500425e-01 0.125 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.500425e-01 0.125 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.500425e-01 0.125 0 0
Extension of Telomeres R-HSA-180786 7.501354e-01 0.125 0 0
Protein folding R-HSA-391251 7.511222e-01 0.124 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.546179e-01 0.122 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.546179e-01 0.122 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.546179e-01 0.122 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.546179e-01 0.122 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.546179e-01 0.122 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.546179e-01 0.122 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.546179e-01 0.122 0 0
Regulation by c-FLIP R-HSA-3371378 7.546179e-01 0.122 0 0
Dimerization of procaspase-8 R-HSA-69416 7.546179e-01 0.122 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.546179e-01 0.122 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.546179e-01 0.122 0 0
Sodium/Proton exchangers R-HSA-425986 7.546179e-01 0.122 0 0
Hedgehog 'off' state R-HSA-5610787 7.551147e-01 0.122 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.559630e-01 0.121 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.559630e-01 0.121 0 0
Formation of the nephric duct R-HSA-9830364 7.559630e-01 0.121 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.626566e-01 0.118 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.653556e-01 0.116 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.667633e-01 0.115 0 0
Mitophagy R-HSA-5205647 7.667633e-01 0.115 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.667633e-01 0.115 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.706451e-01 0.113 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.706451e-01 0.113 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.724602e-01 0.112 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.724602e-01 0.112 0 0
Metalloprotease DUBs R-HSA-5689901 7.744776e-01 0.111 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.744776e-01 0.111 0 0
TRP channels R-HSA-3295583 7.744776e-01 0.111 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.744776e-01 0.111 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.744776e-01 0.111 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.759243e-01 0.110 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.761837e-01 0.110 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.761837e-01 0.110 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.761837e-01 0.110 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.767083e-01 0.110 0 0
TCR signaling R-HSA-202403 7.783915e-01 0.109 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.824281e-01 0.107 0 0
Regulation of Apoptosis R-HSA-169911 7.825960e-01 0.106 0 0
PERK regulates gene expression R-HSA-381042 7.825960e-01 0.106 0 0
Lipophagy R-HSA-9613354 7.840499e-01 0.106 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.840499e-01 0.106 0 0
CASP8 activity is inhibited R-HSA-5218900 7.840499e-01 0.106 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.840499e-01 0.106 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.840499e-01 0.106 0 0
mRNA Editing R-HSA-75072 7.840499e-01 0.106 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.840499e-01 0.106 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.840499e-01 0.106 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.840499e-01 0.106 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.840499e-01 0.106 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.840499e-01 0.106 0 0
Signaling by PDGF R-HSA-186797 7.880582e-01 0.103 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.881421e-01 0.103 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.881421e-01 0.103 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.891229e-01 0.103 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.891229e-01 0.103 0 0
Meiotic synapsis R-HSA-1221632 7.891229e-01 0.103 0 0
Diseases of programmed cell death R-HSA-9645723 7.904172e-01 0.102 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.913949e-01 0.102 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.913949e-01 0.102 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.913949e-01 0.102 0 0
Platelet sensitization by LDL R-HSA-432142 7.913949e-01 0.102 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.918231e-01 0.101 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.919382e-01 0.101 0 0
Gap junction trafficking R-HSA-190828 7.919382e-01 0.101 0 0
SARS-CoV Infections R-HSA-9679506 7.970066e-01 0.099 1 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.975617e-01 0.098 0 0
RNA Polymerase III Transcription R-HSA-74158 7.975617e-01 0.098 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.975617e-01 0.098 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.975617e-01 0.098 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.994341e-01 0.097 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.996921e-01 0.097 0 0
Co-inhibition by PD-1 R-HSA-389948 7.999627e-01 0.097 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.016775e-01 0.096 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.033379e-01 0.095 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.033379e-01 0.095 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.051247e-01 0.094 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.080424e-01 0.093 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.080424e-01 0.093 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.080424e-01 0.093 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.099533e-01 0.092 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.099533e-01 0.092 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.099533e-01 0.092 0 0
Binding and entry of HIV virion R-HSA-173107 8.099533e-01 0.092 0 0
DNA replication initiation R-HSA-68952 8.099533e-01 0.092 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.099533e-01 0.092 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.099533e-01 0.092 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.099533e-01 0.092 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.099533e-01 0.092 0 0
Formation of apoptosome R-HSA-111458 8.099533e-01 0.092 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.099533e-01 0.092 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.104684e-01 0.091 0 0
Translesion Synthesis by POLH R-HSA-110320 8.104684e-01 0.091 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.104684e-01 0.091 0 0
Specification of the neural plate border R-HSA-9834899 8.104684e-01 0.091 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.104684e-01 0.091 0 0
Regulation of signaling by CBL R-HSA-912631 8.104684e-01 0.091 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.104684e-01 0.091 0 0
The NLRP3 inflammasome R-HSA-844456 8.104684e-01 0.091 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.116843e-01 0.091 0 0
G alpha (z) signalling events R-HSA-418597 8.132733e-01 0.090 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.176393e-01 0.087 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.191285e-01 0.087 0 0
Cellular response to hypoxia R-HSA-1234174 8.214895e-01 0.085 0 0
Late endosomal microautophagy R-HSA-9615710 8.231816e-01 0.085 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.249899e-01 0.084 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.265632e-01 0.083 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.278807e-01 0.082 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.279693e-01 0.082 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.279693e-01 0.082 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.279693e-01 0.082 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.284058e-01 0.082 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.294994e-01 0.081 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.327508e-01 0.079 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.327508e-01 0.079 0 0
LGI-ADAM interactions R-HSA-5682910 8.327508e-01 0.079 0 0
vRNP Assembly R-HSA-192905 8.327508e-01 0.079 0 0
vRNA Synthesis R-HSA-192814 8.327508e-01 0.079 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.327508e-01 0.079 0 0
Bicarbonate transporters R-HSA-425381 8.327508e-01 0.079 0 0
Transport of RCbl within the body R-HSA-9758890 8.327508e-01 0.079 0 0
Chylomicron assembly R-HSA-8963888 8.327508e-01 0.079 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.327508e-01 0.079 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.327508e-01 0.079 0 0
Prostanoid ligand receptors R-HSA-391908 8.327508e-01 0.079 0 0
Interleukin-2 signaling R-HSA-9020558 8.327508e-01 0.079 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.366271e-01 0.077 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.372887e-01 0.077 0 0
Activation of BH3-only proteins R-HSA-114452 8.372887e-01 0.077 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.375068e-01 0.077 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.375068e-01 0.077 0 0
Interleukin-12 signaling R-HSA-9020591 8.388358e-01 0.076 0 0
GPER1 signaling R-HSA-9634597 8.407241e-01 0.075 0 0
Kidney development R-HSA-9830369 8.413868e-01 0.075 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.440003e-01 0.074 0 0
Basigin interactions R-HSA-210991 8.440003e-01 0.074 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.440003e-01 0.074 0 0
Generation of second messenger molecules R-HSA-202433 8.492647e-01 0.071 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.492647e-01 0.071 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.504130e-01 0.070 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.504130e-01 0.070 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.526453e-01 0.069 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.528148e-01 0.069 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.528148e-01 0.069 0 0
ERKs are inactivated R-HSA-202670 8.528148e-01 0.069 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.528148e-01 0.069 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.528148e-01 0.069 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.528148e-01 0.069 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.586620e-01 0.066 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.602940e-01 0.065 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.602940e-01 0.065 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.626047e-01 0.064 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.704728e-01 0.060 0 0
Regulation of IFNG signaling R-HSA-877312 8.704728e-01 0.060 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.704728e-01 0.060 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.704728e-01 0.060 0 0
Leading Strand Synthesis R-HSA-69109 8.704728e-01 0.060 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.704728e-01 0.060 0 0
Polymerase switching R-HSA-69091 8.704728e-01 0.060 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.704728e-01 0.060 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.704728e-01 0.060 0 0
Disorders of Nervous System Development R-HSA-9697154 8.704728e-01 0.060 0 0
Pervasive developmental disorders R-HSA-9005895 8.704728e-01 0.060 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.704728e-01 0.060 0 0
Interleukin-15 signaling R-HSA-8983432 8.704728e-01 0.060 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.706261e-01 0.060 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.706261e-01 0.060 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.707915e-01 0.060 0 0
Meiotic recombination R-HSA-912446 8.707915e-01 0.060 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.720523e-01 0.059 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.720523e-01 0.059 0 0
LDL clearance R-HSA-8964038 8.720523e-01 0.059 0 0
PKR-mediated signaling R-HSA-9833482 8.720720e-01 0.059 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.728002e-01 0.059 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.728002e-01 0.059 0 0
RSV-host interactions R-HSA-9833110 8.729358e-01 0.059 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.775100e-01 0.057 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.796842e-01 0.056 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.802927e-01 0.055 0 0
Telomere Maintenance R-HSA-157579 8.810609e-01 0.055 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.842652e-01 0.053 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.842652e-01 0.053 0 0
Growth hormone receptor signaling R-HSA-982772 8.842652e-01 0.053 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.843900e-01 0.053 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.860133e-01 0.053 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.860133e-01 0.053 0 0
Chylomicron remodeling R-HSA-8963901 8.860133e-01 0.053 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.860133e-01 0.053 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.860133e-01 0.053 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.860133e-01 0.053 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.860133e-01 0.053 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.860133e-01 0.053 0 0
HCMV Infection R-HSA-9609646 8.873101e-01 0.052 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.874210e-01 0.052 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.890155e-01 0.051 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.893254e-01 0.051 1 0
Signaling by SCF-KIT R-HSA-1433557 8.893254e-01 0.051 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.940821e-01 0.049 0 0
eNOS activation R-HSA-203615 8.940821e-01 0.049 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.940821e-01 0.049 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.940821e-01 0.049 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.940821e-01 0.049 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.953902e-01 0.048 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.953902e-01 0.048 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.959091e-01 0.048 0 0
IGF1R signaling cascade R-HSA-2428924 8.960494e-01 0.048 0 0
Insulin receptor signalling cascade R-HSA-74751 8.960494e-01 0.048 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.972045e-01 0.047 0 0
HCMV Late Events R-HSA-9610379 8.973837e-01 0.047 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.996901e-01 0.046 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.996901e-01 0.046 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.996901e-01 0.046 0 0
Prolactin receptor signaling R-HSA-1170546 8.996901e-01 0.046 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.996901e-01 0.046 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.996901e-01 0.046 0 0
Regulation of KIT signaling R-HSA-1433559 8.996901e-01 0.046 0 0
HDL assembly R-HSA-8963896 8.996901e-01 0.046 0 0
Zinc transporters R-HSA-435354 8.996901e-01 0.046 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.996901e-01 0.046 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.027144e-01 0.044 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.029462e-01 0.044 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.030377e-01 0.044 0 0
Protein ubiquitination R-HSA-8852135 9.038333e-01 0.044 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.046147e-01 0.044 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.046147e-01 0.044 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.046147e-01 0.044 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.055127e-01 0.043 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.055127e-01 0.043 0 0
Hyaluronan degradation R-HSA-2160916 9.055127e-01 0.043 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.055127e-01 0.043 0 0
Interleukin-7 signaling R-HSA-1266695 9.055127e-01 0.043 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.056154e-01 0.043 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.056154e-01 0.043 0 0
Somitogenesis R-HSA-9824272 9.056154e-01 0.043 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.096585e-01 0.041 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.117265e-01 0.040 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.117265e-01 0.040 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.117265e-01 0.040 0 0
Protein lipoylation R-HSA-9857492 9.117265e-01 0.040 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.117265e-01 0.040 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.117265e-01 0.040 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.117265e-01 0.040 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.147129e-01 0.039 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.147129e-01 0.039 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.152263e-01 0.038 0 0
IRS-mediated signalling R-HSA-112399 9.166844e-01 0.038 0 0
tRNA processing R-HSA-72306 9.180903e-01 0.037 0 0
Degradation of AXIN R-HSA-4641257 9.189232e-01 0.037 0 0
Integration of energy metabolism R-HSA-163685 9.211769e-01 0.036 0 0
Interleukin-12 family signaling R-HSA-447115 9.217544e-01 0.035 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.223193e-01 0.035 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.223193e-01 0.035 0 0
Regulation of BACH1 activity R-HSA-9708530 9.223193e-01 0.035 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.223193e-01 0.035 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.223193e-01 0.035 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.223193e-01 0.035 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.223193e-01 0.035 0 0
Triglyceride biosynthesis R-HSA-75109 9.230665e-01 0.035 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.230665e-01 0.035 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.230665e-01 0.035 0 0
Insulin processing R-HSA-264876 9.230665e-01 0.035 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.259407e-01 0.033 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.259407e-01 0.033 0 0
Co-stimulation by CD28 R-HSA-389356 9.260704e-01 0.033 0 0
Gluconeogenesis R-HSA-70263 9.260704e-01 0.033 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.262560e-01 0.033 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.267280e-01 0.033 0 0
PPARA activates gene expression R-HSA-1989781 9.267333e-01 0.033 0 0
Telomere Extension By Telomerase R-HSA-171319 9.306440e-01 0.031 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.306440e-01 0.031 0 0
Inflammasomes R-HSA-622312 9.306440e-01 0.031 0 0
Signaling by FGFR2 R-HSA-5654738 9.310933e-01 0.031 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.316415e-01 0.031 0 0
Phase 2 - plateau phase R-HSA-5576893 9.316415e-01 0.031 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.316415e-01 0.031 0 0
Synthesis of PG R-HSA-1483148 9.316415e-01 0.031 0 0
Coenzyme A biosynthesis R-HSA-196783 9.316415e-01 0.031 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.316415e-01 0.031 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.316415e-01 0.031 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.323967e-01 0.030 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.323967e-01 0.030 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.336518e-01 0.030 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.337137e-01 0.030 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.338235e-01 0.030 0 0
Downstream TCR signaling R-HSA-202424 9.355400e-01 0.029 0 0
Regulation of insulin secretion R-HSA-422356 9.360023e-01 0.029 0 0
PI3K Cascade R-HSA-109704 9.373931e-01 0.028 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.373931e-01 0.028 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.375114e-01 0.028 0 0
DARPP-32 events R-HSA-180024 9.375114e-01 0.028 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.375114e-01 0.028 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.383303e-01 0.028 0 0
Glycogen metabolism R-HSA-8982491 9.383303e-01 0.028 0 0
Diseases of Immune System R-HSA-5260271 9.383303e-01 0.028 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.383303e-01 0.028 0 0
Interleukin-2 family signaling R-HSA-451927 9.383303e-01 0.028 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.393252e-01 0.027 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.398454e-01 0.027 0 0
Glycogen storage diseases R-HSA-3229121 9.398454e-01 0.027 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.398454e-01 0.027 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.437299e-01 0.025 0 0
DAP12 signaling R-HSA-2424491 9.437299e-01 0.025 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.437299e-01 0.025 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.437299e-01 0.025 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.437788e-01 0.025 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.437788e-01 0.025 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.441467e-01 0.025 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.470652e-01 0.024 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.470652e-01 0.024 0 0
Apoptotic factor-mediated response R-HSA-111471 9.470652e-01 0.024 0 0
Tie2 Signaling R-HSA-210993 9.470652e-01 0.024 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.470652e-01 0.024 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.470652e-01 0.024 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.471167e-01 0.024 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.471167e-01 0.024 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.475580e-01 0.023 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.487774e-01 0.023 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.493564e-01 0.023 0 0
Cargo concentration in the ER R-HSA-5694530 9.493564e-01 0.023 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.515549e-01 0.022 0 0
Developmental Cell Lineages R-HSA-9734767 9.523508e-01 0.021 0 0
Activation of GABAB receptors R-HSA-991365 9.533591e-01 0.021 0 0
GABA B receptor activation R-HSA-977444 9.533591e-01 0.021 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.533591e-01 0.021 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.534189e-01 0.021 0 0
Pyrimidine biosynthesis R-HSA-500753 9.534189e-01 0.021 0 0
Other interleukin signaling R-HSA-449836 9.534189e-01 0.021 0 0
HDL remodeling R-HSA-8964058 9.534189e-01 0.021 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.534189e-01 0.021 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.534189e-01 0.021 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.564221e-01 0.019 0 0
Signaling by FGFR4 R-HSA-5654743 9.575554e-01 0.019 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.575554e-01 0.019 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.590102e-01 0.018 0 0
Glycogen synthesis R-HSA-3322077 9.590102e-01 0.018 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.590102e-01 0.018 0 0
Pregnenolone biosynthesis R-HSA-196108 9.590102e-01 0.018 0 0
Protein hydroxylation R-HSA-9629569 9.590102e-01 0.018 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.594254e-01 0.018 1 0
SLC transporter disorders R-HSA-5619102 9.604885e-01 0.018 0 0
Phospholipid metabolism R-HSA-1483257 9.611374e-01 0.017 0 0
Proteasome assembly R-HSA-9907900 9.613957e-01 0.017 0 0
Surfactant metabolism R-HSA-5683826 9.613957e-01 0.017 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.616267e-01 0.017 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.616949e-01 0.017 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.624600e-01 0.017 0 0
Parasite infection R-HSA-9664407 9.624600e-01 0.017 0 0
Leishmania phagocytosis R-HSA-9664417 9.624600e-01 0.017 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.625356e-01 0.017 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.625356e-01 0.017 0 0
Transmission across Chemical Synapses R-HSA-112315 9.625474e-01 0.017 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.631883e-01 0.016 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.631883e-01 0.016 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.639307e-01 0.016 0 0
G-protein activation R-HSA-202040 9.639307e-01 0.016 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.639307e-01 0.016 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.639307e-01 0.016 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.639307e-01 0.016 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.639307e-01 0.016 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.639307e-01 0.016 0 0
Signaling by FGFR3 R-HSA-5654741 9.649074e-01 0.016 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.649074e-01 0.016 0 0
Regulated Necrosis R-HSA-5218859 9.649167e-01 0.016 0 0
Signal amplification R-HSA-392518 9.669320e-01 0.015 0 0
Hyaluronan metabolism R-HSA-2142845 9.669320e-01 0.015 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.669320e-01 0.015 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.669320e-01 0.015 0 0
Ion channel transport R-HSA-983712 9.679605e-01 0.014 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.682608e-01 0.014 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.682608e-01 0.014 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.682608e-01 0.014 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.682608e-01 0.014 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.682608e-01 0.014 0 0
Assembly Of The HIV Virion R-HSA-175474 9.682608e-01 0.014 0 0
Stimuli-sensing channels R-HSA-2672351 9.688080e-01 0.014 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.699144e-01 0.013 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.703076e-01 0.013 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.703076e-01 0.013 0 0
Mitochondrial biogenesis R-HSA-1592230 9.704000e-01 0.013 0 0
Synthesis of PC R-HSA-1483191 9.710464e-01 0.013 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.712368e-01 0.013 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.720712e-01 0.012 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.720712e-01 0.012 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.720712e-01 0.012 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.720712e-01 0.012 0 0
Signaling by KIT in disease R-HSA-9669938 9.720712e-01 0.012 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.720712e-01 0.012 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.729467e-01 0.012 1 0
PRC2 methylates histones and DNA R-HSA-212300 9.733496e-01 0.012 0 0
Glycosphingolipid transport R-HSA-9845576 9.733496e-01 0.012 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.733496e-01 0.012 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.733496e-01 0.012 0 0
RAB geranylgeranylation R-HSA-8873719 9.736895e-01 0.012 0 0
Intraflagellar transport R-HSA-5620924 9.737202e-01 0.012 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.745571e-01 0.011 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.748055e-01 0.011 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.754244e-01 0.011 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.754244e-01 0.011 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.754244e-01 0.011 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.754244e-01 0.011 0 0
Formation of the ureteric bud R-HSA-9830674 9.754244e-01 0.011 0 0
Syndecan interactions R-HSA-3000170 9.754244e-01 0.011 0 0
Aquaporin-mediated transport R-HSA-445717 9.759449e-01 0.011 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.760894e-01 0.011 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.760894e-01 0.011 0 0
Metabolism of folate and pterines R-HSA-196757 9.760894e-01 0.011 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.763054e-01 0.010 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.763054e-01 0.010 0 0
Signaling by Hedgehog R-HSA-5358351 9.767758e-01 0.010 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.780175e-01 0.010 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.780175e-01 0.010 0 0
Cellular response to starvation R-HSA-9711097 9.781784e-01 0.010 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.783752e-01 0.009 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.783752e-01 0.009 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.783752e-01 0.009 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.783752e-01 0.009 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.785557e-01 0.009 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.787535e-01 0.009 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.799407e-01 0.009 0 0
Adaptive Immune System R-HSA-1280218 9.802255e-01 0.009 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.804043e-01 0.009 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.807746e-01 0.008 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.809718e-01 0.008 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.809718e-01 0.008 0 0
G protein gated Potassium channels R-HSA-1296059 9.809718e-01 0.008 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.809718e-01 0.008 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.809718e-01 0.008 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.809718e-01 0.008 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.809718e-01 0.008 0 0
Retinoid cycle disease events R-HSA-2453864 9.809718e-01 0.008 0 0
Diseases of the neuronal system R-HSA-9675143 9.809718e-01 0.008 0 0
Diseases associated with visual transduction R-HSA-2474795 9.809718e-01 0.008 0 0
Laminin interactions R-HSA-3000157 9.809718e-01 0.008 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.814130e-01 0.008 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.818478e-01 0.008 0 0
Urea cycle R-HSA-70635 9.832568e-01 0.007 0 0
Sphingolipid catabolism R-HSA-9845614 9.832568e-01 0.007 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.845636e-01 0.007 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.851174e-01 0.007 0 0
Cristae formation R-HSA-8949613 9.852675e-01 0.006 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.852675e-01 0.006 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.852675e-01 0.006 0 0
Signaling by BMP R-HSA-201451 9.852675e-01 0.006 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.852675e-01 0.006 0 0
Synthesis of PE R-HSA-1483213 9.852675e-01 0.006 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.852675e-01 0.006 0 0
Signaling by FGFR R-HSA-190236 9.852757e-01 0.006 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.854458e-01 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 9.861750e-01 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 9.866547e-01 0.006 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.870368e-01 0.006 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.870368e-01 0.006 0 0
Pyrimidine salvage R-HSA-73614 9.870368e-01 0.006 0 0
Pyroptosis R-HSA-5620971 9.870368e-01 0.006 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.876221e-01 0.005 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.876221e-01 0.005 0 0
Depyrimidination R-HSA-73928 9.876221e-01 0.005 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.876221e-01 0.005 0 0
Signaling by FGFR1 R-HSA-5654736 9.880878e-01 0.005 0 0
DNA methylation R-HSA-5334118 9.885938e-01 0.005 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.885938e-01 0.005 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.885938e-01 0.005 0 0
Glucagon-type ligand receptors R-HSA-420092 9.885938e-01 0.005 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.886952e-01 0.005 0 0
COPII-mediated vesicle transport R-HSA-204005 9.894793e-01 0.005 0 0
Signaling by Insulin receptor R-HSA-74752 9.896015e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.896015e-01 0.005 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.899638e-01 0.004 0 0
Neurotransmitter clearance R-HSA-112311 9.899638e-01 0.004 0 0
DAP12 interactions R-HSA-2172127 9.900868e-01 0.004 0 0
Cardiac conduction R-HSA-5576891 9.901685e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.902432e-01 0.004 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.911693e-01 0.004 0 0
Budding and maturation of HIV virion R-HSA-162588 9.911693e-01 0.004 0 0
Triglyceride metabolism R-HSA-8979227 9.912045e-01 0.004 0 0
Neddylation R-HSA-8951664 9.912065e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.920561e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.920561e-01 0.003 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.920699e-01 0.003 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.920699e-01 0.003 0 0
DAG1 glycosylations R-HSA-8931838 9.922301e-01 0.003 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.922301e-01 0.003 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.922301e-01 0.003 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.925847e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.926486e-01 0.003 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.931635e-01 0.003 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.931635e-01 0.003 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.931635e-01 0.003 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.933984e-01 0.003 0 0
Mitochondrial protein import R-HSA-1268020 9.935264e-01 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.936631e-01 0.003 0 0
Metal ion SLC transporters R-HSA-425410 9.936631e-01 0.003 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.939849e-01 0.003 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.940999e-01 0.003 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.943375e-01 0.002 0 0
Ribosome-associated quality control R-HSA-9948299 9.945258e-01 0.002 0 0
Gap junction assembly R-HSA-190861 9.947076e-01 0.002 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.947076e-01 0.002 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.947076e-01 0.002 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.947076e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.947076e-01 0.002 0 0
ER-Phagosome pathway R-HSA-1236974 9.947984e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.951974e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.951974e-01 0.002 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.953435e-01 0.002 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.954819e-01 0.002 0 0
Triglyceride catabolism R-HSA-163560 9.959030e-01 0.002 0 0
GPVI-mediated activation cascade R-HSA-114604 9.959030e-01 0.002 0 0
Neutrophil degranulation R-HSA-6798695 9.961951e-01 0.002 0 0
Voltage gated Potassium channels R-HSA-1296072 9.963953e-01 0.002 0 0
Cleavage of the damaged purine R-HSA-110331 9.963953e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.963953e-01 0.002 0 0
NCAM1 interactions R-HSA-419037 9.963953e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.963953e-01 0.002 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.963969e-01 0.002 0 0
Neuronal System R-HSA-112316 9.964729e-01 0.002 0 0
Cellular response to chemical stress R-HSA-9711123 9.967762e-01 0.001 0 0
Depurination R-HSA-73927 9.968285e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.968285e-01 0.001 0 0
Purine salvage R-HSA-74217 9.968285e-01 0.001 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.969845e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.970070e-01 0.001 0 0
RAS processing R-HSA-9648002 9.972097e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.972097e-01 0.001 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.972734e-01 0.001 0 0
Platelet homeostasis R-HSA-418346 9.974004e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.975168e-01 0.001 0 0
Eukaryotic Translation Termination R-HSA-72764 9.975169e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.975450e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.977349e-01 0.001 1 0
Antigen processing-Cross presentation R-HSA-1236975 9.978269e-01 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.979642e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.981848e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.982277e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.982695e-01 0.001 0 0
Peptide chain elongation R-HSA-156902 9.983365e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.983818e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.984514e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.984868e-01 0.001 0 0
Defective pyroptosis R-HSA-9710421 9.985292e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.985576e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.987002e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.987060e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.987060e-01 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.987691e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.987935e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.987935e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.988445e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.988616e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.989162e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.989984e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.989984e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.991189e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.991189e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.991907e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.993181e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.993585e-01 0.000 0 0
Protein localization R-HSA-9609507 9.993867e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.994722e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.994722e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.994917e-01 0.000 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.995105e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.995477e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.995477e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.995879e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.995916e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.996390e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.996609e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.996815e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.997054e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.997067e-01 0.000 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.997145e-01 0.000 0 0
Platelet degranulation R-HSA-114608 9.997183e-01 0.000 0 0
Immune System R-HSA-168256 9.997263e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.997554e-01 0.000 0 0
rRNA processing R-HSA-72312 9.997560e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.997766e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998009e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998009e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.998103e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998107e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.998107e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998290e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.998335e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998418e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.998535e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998602e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.998602e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998867e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999224e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999322e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.999322e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999322e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999389e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999397e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999513e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999538e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999594e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999594e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999683e-01 0.000 1 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999686e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999724e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999765e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999834e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999835e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999836e-01 0.000 0 0
Translation R-HSA-72766 9.999899e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999912e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999923e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999929e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999948e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999976e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.999979e-01 0.000 1 0
Leishmania parasite growth and survival R-HSA-9664433 9.999981e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999981e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999981e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999986e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999988e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999989e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999989e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999991e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999992e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999993e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999994e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999995e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999996e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999998e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999998e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999999e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 1 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 1 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Suppression of apoptosis R-HSA-9635465 1.000000e+00 0.000 1 1
Maturation of nucleoprotein R-HSA-9683610 1.000000e+00 0.000 1 1
Translation of Structural Proteins R-HSA-9683701 1.000000e+00 0.000 1 0
Maturation of nucleoprotein R-HSA-9694631 1.000000e+00 0.000 1 1
Translation of Structural Proteins R-HSA-9694635 1.000000e+00 0.000 1 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 0.000002 5.617 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000009 5.053 1 0
Cell Cycle, Mitotic R-HSA-69278 0.000010 4.994 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.000012 4.933 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.000013 4.902 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.000021 4.680 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.000022 4.663 0 0
NRAGE signals death through JNK R-HSA-193648 0.000024 4.620 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.000029 4.531 0 0
Signal Transduction R-HSA-162582 0.000035 4.457 1 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.000038 4.416 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.000042 4.376 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.000060 4.221 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.000092 4.036 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.000099 4.005 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.000114 3.941 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.000122 3.913 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.000178 3.749 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.000225 3.648 0 0
Death Receptor Signaling R-HSA-73887 0.000221 3.656 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.000260 3.584 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.000297 3.527 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.000332 3.479 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.000332 3.479 0 0
Cellular Senescence R-HSA-2559583 0.000349 3.457 0 0
Signaling by Hippo R-HSA-2028269 0.000355 3.450 0 0
Chromatin organization R-HSA-4839726 0.000371 3.430 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.000486 3.313 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.000486 3.313 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.000525 3.280 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.000525 3.280 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.000466 3.331 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.000452 3.345 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.000662 3.179 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.000653 3.185 0 0
Nuclear import of Rev protein R-HSA-180746 0.000806 3.094 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.000900 3.046 0 0
Cellular response to heat stress R-HSA-3371556 0.000918 3.037 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.000931 3.031 0 0
Activation of BH3-only proteins R-HSA-114452 0.000931 3.031 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.000987 3.006 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.001071 2.970 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.001124 2.949 0 0
Chromatin modifying enzymes R-HSA-3247509 0.001272 2.896 0 0
Formation of axial mesoderm R-HSA-9796292 0.001509 2.821 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.001453 2.838 0 0
MTOR signalling R-HSA-165159 0.001434 2.844 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.001453 2.838 0 0
FOXO-mediated transcription R-HSA-9614085 0.001378 2.861 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.001509 2.821 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.001571 2.804 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.001675 2.776 0 0
Signaling by ALK in cancer R-HSA-9700206 0.001675 2.776 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.001746 2.758 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.001909 2.719 0 0
Signaling by ALK R-HSA-201556 0.002087 2.681 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.002087 2.681 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.002233 2.651 0 0
Cell Cycle Checkpoints R-HSA-69620 0.002155 2.667 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.002480 2.606 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.002480 2.606 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.002792 2.554 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.002931 2.533 0 0
Inositol phosphate metabolism R-HSA-1483249 0.002770 2.558 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.002792 2.554 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.002931 2.533 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.002792 2.554 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.002932 2.533 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.002932 2.533 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.002932 2.533 0 0
M Phase R-HSA-68886 0.003278 2.484 0 0
TGFBR3 expression R-HSA-9839394 0.003652 2.438 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.003601 2.444 0 0
G0 and Early G1 R-HSA-1538133 0.004452 2.351 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.004452 2.351 0 0
Repression of WNT target genes R-HSA-4641265 0.005038 2.298 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.004950 2.305 0 0
G alpha (12/13) signalling events R-HSA-416482 0.005069 2.295 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.005146 2.289 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.005297 2.276 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.005827 2.235 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.006693 2.174 0 0
mTORC1-mediated signalling R-HSA-166208 0.006526 2.185 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.006286 2.202 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.006418 2.193 0 0
Gene expression (Transcription) R-HSA-74160 0.006489 2.188 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.005899 2.229 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.006693 2.174 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.006286 2.202 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.006283 2.202 0 0
Regulation of beta-cell development R-HSA-186712 0.006577 2.182 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.007149 2.146 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.007221 2.141 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.007396 2.131 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.007976 2.098 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.007976 2.098 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.007412 2.130 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.007960 2.099 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.007862 2.104 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.009154 2.038 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.009254 2.034 0 0
tRNA processing in the nucleus R-HSA-6784531 0.009386 2.028 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.009470 2.024 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.010710 1.970 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.009927 2.003 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.010226 1.990 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.011718 1.931 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.011718 1.931 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.011857 1.926 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.011857 1.926 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.012273 1.911 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.012273 1.911 0 0
Signaling by NTRKs R-HSA-166520 0.012592 1.900 0 0
Mitotic Prophase R-HSA-68875 0.012743 1.895 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.013989 1.854 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.013749 1.862 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.013989 1.854 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.014227 1.847 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.014407 1.841 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.014839 1.829 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.014839 1.829 0 0
snRNP Assembly R-HSA-191859 0.015011 1.824 0 0
Metabolism of non-coding RNA R-HSA-194441 0.015011 1.824 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.015728 1.803 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.016327 1.787 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.016327 1.787 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.016327 1.787 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.016327 1.787 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.016327 1.787 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.017323 1.761 0 0
Mitotic Prometaphase R-HSA-68877 0.016716 1.777 0 0
Apoptotic execution phase R-HSA-75153 0.017547 1.756 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.017676 1.753 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.017972 1.745 0 0
G2/M Transition R-HSA-69275 0.018153 1.741 0 0
Apoptosis R-HSA-109581 0.018306 1.737 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.018565 1.731 0 0
Signaling by NOTCH1 R-HSA-1980143 0.018566 1.731 0 0
Regulation of gap junction activity R-HSA-191650 0.020964 1.679 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.020964 1.679 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.020964 1.679 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.020515 1.688 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.020515 1.688 0 0
Signaling by LTK R-HSA-9842663 0.020515 1.688 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.019957 1.700 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.020515 1.688 1 1
Regulation of gene expression in beta cells R-HSA-210745 0.021952 1.659 0 0
NGF-stimulated transcription R-HSA-9031628 0.022142 1.655 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.022573 1.646 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.022719 1.644 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.022719 1.644 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.022719 1.644 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.022809 1.642 0 0
Membrane Trafficking R-HSA-199991 0.023351 1.632 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.023807 1.623 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.025028 1.602 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.025549 1.593 0 0
G1/S-Specific Transcription R-HSA-69205 0.025710 1.590 0 0
RET signaling R-HSA-8853659 0.025710 1.590 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.025729 1.590 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.025913 1.586 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.028324 1.548 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.026519 1.576 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.028324 1.548 0 0
Deubiquitination R-HSA-5688426 0.029602 1.529 0 0
Calcineurin activates NFAT R-HSA-2025928 0.030007 1.523 0 0
ALK mutants bind TKIs R-HSA-9700645 0.030007 1.523 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.030192 1.520 0 0
Rap1 signalling R-HSA-392517 0.030496 1.516 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.030932 1.510 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.031047 1.508 0 0
IRS activation R-HSA-74713 0.031047 1.508 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.031047 1.508 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.031255 1.505 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.032656 1.486 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.032656 1.486 0 0
MAPK family signaling cascades R-HSA-5683057 0.033123 1.480 0 0
Centrosome maturation R-HSA-380287 0.033633 1.473 0 0
Signal attenuation R-HSA-74749 0.038402 1.416 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.036075 1.443 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.037663 1.424 0 0
Nuclear RNA decay R-HSA-9930044 0.037740 1.423 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.038954 1.409 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.034499 1.462 0 0
DCC mediated attractive signaling R-HSA-418885 0.038522 1.414 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.034445 1.463 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.036324 1.440 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.036324 1.440 0 0
Signaling by Leptin R-HSA-2586552 0.038402 1.416 0 0
Signaling by TGFBR3 R-HSA-9839373 0.039453 1.404 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.042734 1.369 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.043150 1.365 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.043150 1.365 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.043239 1.364 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.043239 1.364 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.043239 1.364 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.045846 1.339 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.046145 1.336 0 0
Prolonged ERK activation events R-HSA-169893 0.046145 1.336 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.046343 1.334 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.048931 1.310 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.048931 1.310 0 0
Signaling by NOTCH R-HSA-157118 0.049293 1.307 0 0
Nervous system development R-HSA-9675108 0.051679 1.287 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.053108 1.275 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.054264 1.265 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.054602 1.263 0 0
Regulation of TP53 Expression R-HSA-6804754 0.057627 1.239 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.058816 1.231 0 0
Notch-HLH transcription pathway R-HSA-350054 0.056321 1.249 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.063748 1.196 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.056321 1.249 0 0
Activation of RAC1 R-HSA-428540 0.058816 1.231 0 0
S Phase R-HSA-69242 0.056933 1.245 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.057461 1.241 0 0
Adherens junctions interactions R-HSA-418990 0.060528 1.218 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.055607 1.255 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.058816 1.231 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.058536 1.233 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.063863 1.195 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.063896 1.195 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.064347 1.191 1 1
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.066315 1.178 0 0
Recycling of eIF2:GDP R-HSA-72731 0.073597 1.133 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.070809 1.150 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.070809 1.150 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.070809 1.150 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.070809 1.150 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.070809 1.150 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.070809 1.150 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.070809 1.150 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.074022 1.131 0 0
Ephrin signaling R-HSA-3928664 0.074022 1.131 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.081675 1.088 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.076000 1.119 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.076000 1.119 0 0
Interleukin-15 signaling R-HSA-8983432 0.070809 1.150 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.079752 1.098 0 0
Polo-like kinase mediated events R-HSA-156711 0.074022 1.131 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.081675 1.088 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.081675 1.088 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.073597 1.133 0 0
Signaling by RAS mutants R-HSA-6802949 0.081675 1.088 0 0
Signaling by WNT in cancer R-HSA-4791275 0.078097 1.107 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.080690 1.093 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.071153 1.148 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.069224 1.160 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.069224 1.160 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.069224 1.160 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.069224 1.160 0 0
Cell junction organization R-HSA-446728 0.075027 1.125 0 0
HATs acetylate histones R-HSA-3214847 0.071888 1.143 0 0
Mitotic Anaphase R-HSA-68882 0.080663 1.093 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.069224 1.160 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.079492 1.100 0 0
Cell-Cell communication R-HSA-1500931 0.077935 1.108 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.069224 1.160 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.073597 1.133 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.073009 1.137 0 0
Neurodegenerative Diseases R-HSA-8863678 0.073009 1.137 0 0
Glycolysis R-HSA-70171 0.076346 1.117 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.068333 1.165 0 0
PTEN Regulation R-HSA-6807070 0.083023 1.081 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.083897 1.076 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.083949 1.076 0 0
Frs2-mediated activation R-HSA-170968 0.083949 1.076 0 0
L1CAM interactions R-HSA-373760 0.084306 1.074 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 0.084648 1.072 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 0.084648 1.072 0 0
Axonal growth stimulation R-HSA-209563 0.084648 1.072 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.084648 1.072 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.084648 1.072 0 0
Circadian clock R-HSA-9909396 0.086422 1.063 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.086615 1.062 0 0
Axon guidance R-HSA-422475 0.086953 1.061 0 0
Signaling by NOTCH3 R-HSA-9012852 0.088276 1.054 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 0.091827 1.037 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 0.091827 1.037 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.091827 1.037 0 0
Formation of annular gap junctions R-HSA-196025 0.091501 1.039 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.111008 0.955 0 0
Lipophagy R-HSA-9613354 0.111008 0.955 0 0
Gap junction degradation R-HSA-190873 0.111008 0.955 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.098189 1.008 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.098189 1.008 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.092224 1.035 0 0
RAF activation R-HSA-5673000 0.105164 0.978 0 0
MAP2K and MAPK activation R-HSA-5674135 0.105444 0.977 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.105444 0.977 0 0
Formation of definitive endoderm R-HSA-9823730 0.096711 1.015 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.111008 0.955 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.091501 1.039 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.095972 1.018 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.111008 0.955 0 0
Signaling by NOTCH4 R-HSA-9013694 0.104154 0.982 0 0
RNA Polymerase II Transcription R-HSA-73857 0.090957 1.041 0 0
Selective autophagy R-HSA-9663891 0.091802 1.037 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.096771 1.014 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.098189 1.008 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.098189 1.008 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.097665 1.010 1 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.091312 1.039 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.094757 1.023 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.111008 0.955 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.111008 0.955 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.091312 1.039 0 0
Gastrulation R-HSA-9758941 0.091777 1.037 0 0
Developmental Biology R-HSA-1266738 0.109067 0.962 0 0
G2/M Checkpoints R-HSA-69481 0.099319 1.003 0 0
Programmed Cell Death R-HSA-5357801 0.106683 0.972 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.091501 1.039 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.111008 0.955 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.113468 0.945 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.113468 0.945 0 0
p75NTR signals via NF-kB R-HSA-193639 0.113468 0.945 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.113738 0.944 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.114322 0.942 0 0
NADE modulates death signalling R-HSA-205025 0.114655 0.941 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.114655 0.941 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.114655 0.941 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.114655 0.941 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.114655 0.941 0 0
Signalling to ERKs R-HSA-187687 0.115179 0.939 0 0
Generic Transcription Pathway R-HSA-212436 0.116589 0.933 0 0
Co-inhibition by PD-1 R-HSA-389948 0.120136 0.920 0 0
EPH-Ephrin signaling R-HSA-2682334 0.122374 0.912 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.122491 0.912 0 0
Host Interactions of HIV factors R-HSA-162909 0.125338 0.902 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.129233 0.889 1 0
Phosphorylation of the APC/C R-HSA-176412 0.129721 0.887 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.129721 0.887 0 0
mRNA 3'-end processing R-HSA-72187 0.130411 0.885 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.130833 0.883 0 0
Regulation of CDH11 function R-HSA-9762292 0.131941 0.880 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.132636 0.877 0 0
Cyclin D associated events in G1 R-HSA-69231 0.133924 0.873 0 0
G1 Phase R-HSA-69236 0.133924 0.873 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 0.175227 0.756 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 0.250972 0.600 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 0.250972 0.600 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 0.250972 0.600 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.250972 0.600 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.250972 0.600 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 0.250972 0.600 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.250972 0.600 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 0.250972 0.600 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 0.146871 0.833 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.146871 0.833 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.146871 0.833 0 0
G2 Phase R-HSA-68911 0.146871 0.833 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.146871 0.833 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.180639 0.743 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.180639 0.743 0 0
Signaling by RNF43 mutants R-HSA-5340588 0.180639 0.743 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.319765 0.495 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.319765 0.495 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 0.319765 0.495 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 0.319765 0.495 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.319765 0.495 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 0.319765 0.495 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.319765 0.495 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.319765 0.495 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.154118 0.812 0 0
Signaling by APC mutants R-HSA-4839744 0.154118 0.812 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.154118 0.812 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.154118 0.812 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.154118 0.812 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.250693 0.601 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.250693 0.601 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.250693 0.601 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.250693 0.601 0 0
SOS-mediated signalling R-HSA-112412 0.250693 0.601 0 0
Disinhibition of SNARE formation R-HSA-114516 0.250693 0.601 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.250693 0.601 0 0
MET activates STAT3 R-HSA-8875791 0.382244 0.418 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 0.382244 0.418 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.382244 0.418 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.382244 0.418 0 0
Signalling to STAT3 R-HSA-198745 0.382244 0.418 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.382244 0.418 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.382244 0.418 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 0.382244 0.418 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.146873 0.833 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.201475 0.696 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.201475 0.696 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.286122 0.543 0 0
Type I hemidesmosome assembly R-HSA-446107 0.286122 0.543 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.286122 0.543 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.286122 0.543 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.226299 0.645 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.226299 0.645 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.226299 0.645 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.166360 0.779 0 0
Deadenylation of mRNA R-HSA-429947 0.166360 0.779 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.202915 0.693 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.251662 0.599 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.321367 0.493 0 0
ARMS-mediated activation R-HSA-170984 0.321367 0.493 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.321367 0.493 0 0
HCN channels R-HSA-1296061 0.438988 0.358 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.438988 0.358 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 0.438988 0.358 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.438988 0.358 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.438988 0.358 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.438988 0.358 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.438988 0.358 0 0
Signaling by MAP2K mutants R-HSA-9652169 0.438988 0.358 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.438988 0.358 0 0
Signaling by LRP5 mutants R-HSA-5339717 0.438988 0.358 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.222841 0.652 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.277407 0.557 0 0
Erythropoietin activates RAS R-HSA-9027284 0.277407 0.557 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.277407 0.557 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.277407 0.557 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.243248 0.614 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.356162 0.448 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.303385 0.518 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.232689 0.633 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.165889 0.780 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.149452 0.825 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.329462 0.482 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.390294 0.409 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.390294 0.409 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 0.490522 0.309 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 0.490522 0.309 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.490522 0.309 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.490522 0.309 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.237197 0.625 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.268308 0.571 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.306510 0.514 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.355514 0.449 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.328011 0.484 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.423590 0.373 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 0.423590 0.373 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.423590 0.373 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.213983 0.670 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.305006 0.516 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.267576 0.573 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.407101 0.390 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.455917 0.341 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 0.537325 0.270 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.537325 0.270 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 0.537325 0.270 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.537325 0.270 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.537325 0.270 0 0
Phosphorylation of Emi1 R-HSA-176417 0.537325 0.270 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.537325 0.270 0 0
Signaling by MAPK mutants R-HSA-9652817 0.537325 0.270 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.392726 0.406 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.392726 0.406 0 0
HSF1-dependent transactivation R-HSA-3371571 0.342789 0.465 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 0.487171 0.312 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.326401 0.486 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.398851 0.399 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.373648 0.428 0 0
Late endosomal microautophagy R-HSA-9615710 0.435405 0.361 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.435405 0.361 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.247079 0.607 0 0
Activation of the pre-replicative complex R-HSA-68962 0.456436 0.341 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.481840 0.317 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.481840 0.317 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.517277 0.286 0 0
PPARA activates gene expression R-HSA-1989781 0.314083 0.503 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.436173 0.360 0 0
mRNA Splicing R-HSA-72172 0.327724 0.484 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.452911 0.344 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.473144 0.325 0 0
Attenuation phase R-HSA-3371568 0.473144 0.325 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.450952 0.346 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.432426 0.364 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.486011 0.313 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.518452 0.285 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.534371 0.272 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.534371 0.272 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.433603 0.363 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.380030 0.420 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.251088 0.600 0 0
Signaling by NOTCH2 R-HSA-1980145 0.206746 0.685 0 0
Nucleotide Excision Repair R-HSA-5696398 0.243604 0.613 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.212707 0.672 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.207395 0.683 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.238826 0.622 0 0
RNA Polymerase III Transcription R-HSA-74158 0.398851 0.399 0 0
G1/S Transition R-HSA-69206 0.374858 0.426 0 0
Integrin signaling R-HSA-354192 0.177826 0.750 0 0
HCMV Early Events R-HSA-9609690 0.416862 0.380 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.165484 0.781 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.226299 0.645 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.477412 0.321 0 0
Aggrephagy R-HSA-9646399 0.301556 0.521 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.137888 0.860 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.251662 0.599 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.222841 0.652 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.373648 0.428 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.517277 0.286 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.505762 0.296 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.253079 0.597 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.456436 0.341 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.321367 0.493 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.211160 0.675 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.491291 0.309 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.517740 0.286 0 0
UCH proteinases R-HSA-5689603 0.192707 0.715 0 0
Interleukin-2 family signaling R-HSA-451927 0.172135 0.764 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.250693 0.601 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.286122 0.543 0 0
Interleukin-21 signaling R-HSA-9020958 0.321367 0.493 0 0
PI3K/AKT activation R-HSA-198203 0.356162 0.448 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.356162 0.448 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.184781 0.733 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.328011 0.484 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.423590 0.373 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.301556 0.521 0 0
Insulin receptor signalling cascade R-HSA-74751 0.391559 0.407 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.505762 0.296 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.252908 0.597 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.158137 0.801 0 0
Myogenesis R-HSA-525793 0.371186 0.430 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.361191 0.442 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.511467 0.291 0 0
Interleukin-9 signaling R-HSA-8985947 0.286122 0.543 0 0
IGF1R signaling cascade R-HSA-2428924 0.262147 0.581 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.278700 0.555 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.533041 0.273 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.177357 0.751 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.321367 0.493 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.135026 0.870 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.329462 0.482 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.381428 0.419 0 0
VLDLR internalisation and degradation R-HSA-8866427 0.455917 0.341 0 0
Separation of Sister Chromatids R-HSA-2467813 0.168772 0.773 0 0
Orc1 removal from chromatin R-HSA-68949 0.358190 0.446 0 0
Trafficking of AMPA receptors R-HSA-399719 0.477197 0.321 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.502325 0.299 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.497644 0.303 0 0
Interleukin-2 signaling R-HSA-9020558 0.154118 0.812 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.285164 0.545 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.183554 0.736 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.198568 0.702 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.441430 0.355 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.441430 0.355 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.235900 0.627 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.215402 0.667 0 0
Recycling pathway of L1 R-HSA-437239 0.165889 0.780 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.235808 0.627 0 0
Synthesis of DNA R-HSA-69239 0.180842 0.743 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.383440 0.416 0 0
MET activates RAS signaling R-HSA-8851805 0.201475 0.696 0 0
Adipogenesis R-HSA-9843745 0.183338 0.737 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.366425 0.436 0 0
Regulation of TP53 Activity R-HSA-5633007 0.274678 0.561 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.274693 0.561 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.419346 0.377 0 0
TNF signaling R-HSA-75893 0.420123 0.377 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.180639 0.743 0 0
PTK6 Expression R-HSA-8849473 0.250693 0.601 0 0
Adrenoceptors R-HSA-390696 0.286122 0.543 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.137888 0.860 0 0
Formation of the posterior neural plate R-HSA-9832991 0.390294 0.409 0 0
PTK6 Activates STAT3 R-HSA-8849474 0.490522 0.309 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.490522 0.309 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 0.490522 0.309 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.490522 0.309 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.381428 0.419 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.161383 0.792 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.457382 0.340 0 0
DNA strand elongation R-HSA-69190 0.497644 0.303 0 0
Signaling by WNT R-HSA-195721 0.185166 0.732 0 0
Cellular response to hypoxia R-HSA-1234174 0.405941 0.392 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.197797 0.704 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.147817 0.830 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.312266 0.505 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.312266 0.505 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.183554 0.736 0 0
Oncogene Induced Senescence R-HSA-2559585 0.221797 0.654 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.366303 0.436 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.515333 0.288 0 0
Regulation of KIT signaling R-HSA-1433559 0.251662 0.599 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.250337 0.601 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.356162 0.448 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.235900 0.627 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.286122 0.543 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 0.438988 0.358 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.198568 0.702 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.306510 0.514 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 0.423590 0.373 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.192077 0.717 0 0
Signaling by SCF-KIT R-HSA-1433557 0.368611 0.433 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.286548 0.543 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.187111 0.728 0 0
Signaling by FGFR in disease R-HSA-1226099 0.173604 0.760 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.146871 0.833 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.222841 0.652 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.136631 0.864 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.184781 0.733 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.329462 0.482 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.423590 0.373 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.224431 0.649 0 0
Cilium Assembly R-HSA-5617833 0.220028 0.658 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.188211 0.725 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.321367 0.493 0 0
Autophagy R-HSA-9612973 0.243412 0.614 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.166360 0.779 0 0
Interleukin-7 signaling R-HSA-1266695 0.182200 0.739 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.264050 0.578 0 0
Post NMDA receptor activation events R-HSA-438064 0.445127 0.352 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.154752 0.810 0 0
Signaling by VEGF R-HSA-194138 0.280112 0.553 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.507509 0.295 0 0
Cell-cell junction organization R-HSA-421270 0.143861 0.842 0 0
ESR-mediated signaling R-HSA-8939211 0.281287 0.551 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.505471 0.296 0 0
Neurexins and neuroligins R-HSA-6794361 0.518452 0.285 0 0
Metabolism of RNA R-HSA-8953854 0.318502 0.497 0 0
Macroautophagy R-HSA-1632852 0.136195 0.866 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.167171 0.777 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.249787 0.602 0 0
Cellular responses to stress R-HSA-2262752 0.190878 0.719 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 0.175227 0.756 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 0.250972 0.600 0 0
Transport of connexins along the secretory pathway R-HSA-190827 0.250972 0.600 0 0
mRNA Editing: A to I Conversion R-HSA-75064 0.319765 0.495 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.319765 0.495 0 0
C6 deamination of adenosine R-HSA-75102 0.319765 0.495 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.177357 0.751 0 0
Signaling by AXIN mutants R-HSA-4839735 0.177357 0.751 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.382244 0.418 0 0
MET interacts with TNS proteins R-HSA-8875513 0.382244 0.418 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.146873 0.833 0 0
Unwinding of DNA R-HSA-176974 0.321367 0.493 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 0.438988 0.358 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.277407 0.557 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.177826 0.750 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.356162 0.448 0 0
Differentiation of T cells R-HSA-9945266 0.303385 0.518 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.303385 0.518 0 0
Disorders of Developmental Biology R-HSA-9675151 0.329462 0.482 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 0.390294 0.409 0 0
Bicarbonate transporters R-HSA-425381 0.390294 0.409 0 0
Reelin signalling pathway R-HSA-8866376 0.490522 0.309 0 0
NF-kB is activated and signals survival R-HSA-209560 0.423590 0.373 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.381428 0.419 0 0
Ceramide signalling R-HSA-193681 0.537325 0.270 0 0
Mitochondrial biogenesis R-HSA-1592230 0.285918 0.544 0 0
Degradation of CDH1 R-HSA-9766229 0.469532 0.328 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.529096 0.276 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.235879 0.627 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.516262 0.287 0 0
Interleukin-17 signaling R-HSA-448424 0.224640 0.649 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.237629 0.624 0 0
Vesicle-mediated transport R-HSA-5653656 0.463310 0.334 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.407008 0.390 0 0
Ub-specific processing proteases R-HSA-5689880 0.393017 0.406 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.516262 0.287 0 0
Signaling by MET R-HSA-6806834 0.343717 0.464 0 0
Signaling by TGFB family members R-HSA-9006936 0.449965 0.347 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.505762 0.296 0 0
Cellular responses to stimuli R-HSA-8953897 0.372412 0.429 1 0
Pexophagy R-HSA-9664873 0.356162 0.448 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.232689 0.633 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.233528 0.632 0 0
Rab regulation of trafficking R-HSA-9007101 0.285918 0.544 0 0
Signal transduction by L1 R-HSA-445144 0.222841 0.652 0 0
EGFR downregulation R-HSA-182971 0.477197 0.321 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.511467 0.291 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.432909 0.364 0 0
MAP kinase activation R-HSA-450294 0.225689 0.646 0 0
HIV Life Cycle R-HSA-162587 0.183499 0.736 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.356162 0.448 0 0
Kinesins R-HSA-983189 0.481453 0.317 0 0
HIV Infection R-HSA-162906 0.280033 0.553 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.264050 0.578 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.291954 0.535 0 0
Semaphorin interactions R-HSA-373755 0.153054 0.815 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.348574 0.458 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.448529 0.348 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.291954 0.535 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.243604 0.613 0 0
Signal regulatory protein family interactions R-HSA-391160 0.251662 0.599 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 0.321367 0.493 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.277407 0.557 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.356162 0.448 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.423590 0.373 0 0
Disorders of Nervous System Development R-HSA-9697154 0.455917 0.341 0 0
Pervasive developmental disorders R-HSA-9005895 0.455917 0.341 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.455917 0.341 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.505762 0.296 0 0
Signaling by EGFR R-HSA-177929 0.169787 0.770 0 0
RUNX2 regulates bone development R-HSA-8941326 0.237197 0.625 0 0
Ca2+ pathway R-HSA-4086398 0.379728 0.421 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.323332 0.490 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.477197 0.321 0 0
Prolactin receptor signaling R-HSA-1170546 0.517277 0.286 0 0
HDMs demethylate histones R-HSA-3214842 0.182200 0.739 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.243248 0.614 0 0
DNA Damage Bypass R-HSA-73893 0.312266 0.505 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.436173 0.360 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.487298 0.312 0 0
Signaling by ERBB2 R-HSA-1227986 0.334367 0.476 0 0
Signaling by PTK6 R-HSA-8848021 0.377190 0.423 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.377190 0.423 0 0
Oligomerization of connexins into connexons R-HSA-190704 0.250972 0.600 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.146873 0.833 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.251662 0.599 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.321367 0.493 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 0.438988 0.358 0 0
Sensory perception of sour taste R-HSA-9729555 0.438988 0.358 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.243248 0.614 0 0
Activation of AKT2 R-HSA-165158 0.490522 0.309 0 0
PI3K Cascade R-HSA-109704 0.486011 0.313 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.517740 0.286 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.517740 0.286 0 0
Diseases of programmed cell death R-HSA-9645723 0.457796 0.339 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.211160 0.675 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.407101 0.390 0 0
Downstream signal transduction R-HSA-186763 0.477197 0.321 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.305148 0.515 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.349593 0.456 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.144207 0.841 0 0
Carnitine shuttle R-HSA-200425 0.306510 0.514 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.360908 0.443 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.286137 0.543 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.360908 0.443 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.360908 0.443 0 0
Netrin-1 signaling R-HSA-373752 0.385534 0.414 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.250693 0.601 0 0
Suppression of apoptosis R-HSA-9635465 0.390294 0.409 1 1
PECAM1 interactions R-HSA-210990 0.390294 0.409 0 0
TBC/RABGAPs R-HSA-8854214 0.224845 0.648 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.436271 0.360 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.448984 0.348 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.505454 0.296 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.498655 0.302 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.334888 0.475 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.392726 0.406 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.461713 0.336 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.286901 0.542 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.250693 0.601 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.164845 0.783 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.321367 0.493 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.490522 0.309 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.487171 0.312 0 0
FLT3 signaling in disease R-HSA-9682385 0.398851 0.399 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.454793 0.342 0 0
Protein folding R-HSA-391251 0.394930 0.403 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.529096 0.276 0 0
Nephron development R-HSA-9831926 0.183554 0.736 0 0
Gene Silencing by RNA R-HSA-211000 0.180842 0.743 0 0
Maturation of nucleoprotein R-HSA-9683610 0.487171 0.312 1 1
Tie2 Signaling R-HSA-210993 0.381428 0.419 0 0
Specification of primordial germ cells R-HSA-9827857 0.164845 0.783 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.253022 0.597 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.183554 0.736 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.323632 0.490 0 0
Heme signaling R-HSA-9707616 0.362855 0.440 0 0
Josephin domain DUBs R-HSA-5689877 0.356162 0.448 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.303385 0.518 0 0
Physiological factors R-HSA-5578768 0.517277 0.286 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.434537 0.362 1 0
Glucose metabolism R-HSA-70326 0.202798 0.693 0 0
Interleukin-37 signaling R-HSA-9008059 0.268308 0.571 0 0
Growth hormone receptor signaling R-HSA-982772 0.306510 0.514 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 0.537325 0.270 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.211249 0.675 1 1
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.517277 0.286 0 0
IRE1alpha activates chaperones R-HSA-381070 0.272311 0.565 1 0
Striated Muscle Contraction R-HSA-390522 0.537450 0.270 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.537450 0.270 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.537450 0.270 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.537450 0.270 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.539105 0.268 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.543395 0.265 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.546183 0.263 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.546183 0.263 0 0
Biotin transport and metabolism R-HSA-196780 0.546183 0.263 0 0
Formation of the anterior neural plate R-HSA-9823739 0.546183 0.263 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.548264 0.261 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.548264 0.261 0 0
Potential therapeutics for SARS R-HSA-9679191 0.551747 0.258 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.551801 0.258 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.551824 0.258 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.551824 0.258 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.556746 0.254 0 0
Dual Incision in GG-NER R-HSA-5696400 0.556746 0.254 0 0
Mitophagy R-HSA-5205647 0.556746 0.254 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.564401 0.248 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.565512 0.248 0 0
HDACs deacetylate histones R-HSA-3214815 0.565512 0.248 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.573844 0.241 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.573844 0.241 0 0
Killing mechanisms R-HSA-9664420 0.573854 0.241 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.573854 0.241 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.573854 0.241 0 0
PERK regulates gene expression R-HSA-381042 0.575600 0.240 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.579831 0.237 0 0
Signaling by LTK in cancer R-HSA-9842640 0.579831 0.237 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.579831 0.237 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.579831 0.237 0 0
CREB phosphorylation R-HSA-199920 0.579831 0.237 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.579831 0.237 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.579831 0.237 0 0
NADPH regeneration R-HSA-389542 0.579831 0.237 0 0
Nef and signal transduction R-HSA-164944 0.579831 0.237 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.579892 0.237 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.580701 0.236 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.580701 0.236 0 0
Signaling by FGFR1 R-HSA-5654736 0.580701 0.236 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.580701 0.236 0 0
Signaling by Interleukins R-HSA-449147 0.580714 0.236 0 0
Kidney development R-HSA-9830369 0.583488 0.234 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.589715 0.229 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.589715 0.229 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.589715 0.229 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.591849 0.228 0 0
Calmodulin induced events R-HSA-111933 0.593990 0.226 0 0
CaM pathway R-HSA-111997 0.593990 0.226 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.595197 0.225 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.595197 0.225 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.595197 0.225 0 0
Regulation of CDH1 Function R-HSA-9764561 0.595616 0.225 0 0
IRS-mediated signalling R-HSA-112399 0.595616 0.225 0 0
Sensory processing of sound R-HSA-9659379 0.599154 0.222 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.600273 0.222 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.600273 0.222 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.600273 0.222 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.600273 0.222 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.605460 0.218 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.606220 0.217 0 0
PKR-mediated signaling R-HSA-9833482 0.611808 0.213 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.611899 0.213 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.611899 0.213 0 0
Degradation of DVL R-HSA-4641258 0.611899 0.213 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.615840 0.211 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.615840 0.211 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.615840 0.211 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.615840 0.211 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.616220 0.210 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.618435 0.209 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.618435 0.209 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 0.618435 0.209 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 0.618435 0.209 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.618435 0.209 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 0.618435 0.209 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 0.618435 0.209 0 0
VLDL clearance R-HSA-8964046 0.618435 0.209 0 0
Netrin mediated repulsion signals R-HSA-418886 0.618435 0.209 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 0.618435 0.209 0 0
Regulation of PTEN localization R-HSA-8948747 0.618435 0.209 0 0
CHL1 interactions R-HSA-447041 0.618435 0.209 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 0.625437 0.204 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.625437 0.204 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.625437 0.204 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.625437 0.204 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.625437 0.204 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.625437 0.204 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.625437 0.204 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.625437 0.204 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.626082 0.203 0 0
Co-stimulation by CD28 R-HSA-389356 0.626082 0.203 0 0
DNA Repair R-HSA-73894 0.628477 0.202 0 0
MET promotes cell motility R-HSA-8875878 0.629311 0.201 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.635759 0.197 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.635759 0.197 0 0
HIV elongation arrest and recovery R-HSA-167287 0.635759 0.197 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.635759 0.197 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.636699 0.196 0 0
Interleukin-1 signaling R-HSA-9020702 0.636699 0.196 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.637123 0.196 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.637123 0.196 0 0
Gap junction trafficking and regulation R-HSA-157858 0.641349 0.193 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.646214 0.190 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.646214 0.190 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.646214 0.190 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.647490 0.189 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.649354 0.188 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.649354 0.188 0 0
FGFR1 ligand binding and activation R-HSA-190242 0.649354 0.188 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.649354 0.188 0 0
Mismatch Repair R-HSA-5358508 0.649354 0.188 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.649354 0.188 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.652304 0.186 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.652304 0.186 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.653494 0.185 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.653494 0.185 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 0.653494 0.185 0 0
FGFR1b ligand binding and activation R-HSA-190370 0.653494 0.185 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 0.653494 0.185 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.653494 0.185 0 0
Interleukin-23 signaling R-HSA-9020933 0.653494 0.185 0 0
Regulation by c-FLIP R-HSA-3371378 0.653494 0.185 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.653494 0.185 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.653494 0.185 0 0
SLC-mediated bile acid transport R-HSA-9958517 0.653494 0.185 0 0
Dimerization of procaspase-8 R-HSA-69416 0.653494 0.185 0 0
TGFBR3 PTM regulation R-HSA-9839383 0.653494 0.185 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.653494 0.185 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.653494 0.185 0 0
Sodium/Proton exchangers R-HSA-425986 0.653494 0.185 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.653494 0.185 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 0.653494 0.185 0 0
Signaling by Erythropoietin R-HSA-9006335 0.654946 0.184 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.654946 0.184 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.654946 0.184 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.662599 0.179 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.662599 0.179 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.662599 0.179 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.662599 0.179 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.662599 0.179 0 0
Interleukin-1 family signaling R-HSA-446652 0.667530 0.176 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.672040 0.173 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.672040 0.173 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.672040 0.173 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.672040 0.173 0 0
Specification of the neural plate border R-HSA-9834899 0.672040 0.173 0 0
Regulation of signaling by CBL R-HSA-912631 0.672040 0.173 0 0
Maturation of nucleoprotein R-HSA-9694631 0.672040 0.173 1 1
Downstream signaling of activated FGFR4 R-HSA-5654716 0.673394 0.172 0 0
DAP12 signaling R-HSA-2424491 0.673394 0.172 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.673394 0.172 0 0
DNA Replication R-HSA-69306 0.676024 0.170 0 0
FLT3 Signaling R-HSA-9607240 0.678460 0.168 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.684758 0.164 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.684758 0.164 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.684758 0.164 0 0
WNT mediated activation of DVL R-HSA-201688 0.685333 0.164 0 0
CASP8 activity is inhibited R-HSA-5218900 0.685333 0.164 0 0
mRNA Editing R-HSA-75072 0.685333 0.164 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 0.685333 0.164 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.685333 0.164 0 0
Interleukin-1 processing R-HSA-448706 0.685333 0.164 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 0.685333 0.164 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.685333 0.164 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.686565 0.163 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.687966 0.162 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.691106 0.160 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.693520 0.159 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.693520 0.159 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.693520 0.159 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.693520 0.159 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.693520 0.159 0 0
Negative regulation of MET activity R-HSA-6807004 0.693520 0.159 0 0
Protein hydroxylation R-HSA-9629569 0.693520 0.159 0 0
Creatine metabolism R-HSA-71288 0.693520 0.159 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.693793 0.159 0 0
HIV Transcription Initiation R-HSA-167161 0.693793 0.159 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.693793 0.159 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.693793 0.159 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.693793 0.159 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.693793 0.159 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.698226 0.156 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.698411 0.156 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.703840 0.153 0 0
Interferon Signaling R-HSA-913531 0.704020 0.152 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.706824 0.151 0 0
Ca-dependent events R-HSA-111996 0.708596 0.150 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.708596 0.150 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.713823 0.146 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.713823 0.146 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 0.713823 0.146 0 0
Lagging Strand Synthesis R-HSA-69186 0.713823 0.146 0 0
Signalling to RAS R-HSA-167044 0.713823 0.146 0 0
ERK/MAPK targets R-HSA-198753 0.713823 0.146 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.713823 0.146 0 0
MAPK3 (ERK1) activation R-HSA-110056 0.714248 0.146 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.714248 0.146 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.714248 0.146 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 0.714248 0.146 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.714248 0.146 0 0
Serotonin receptors R-HSA-390666 0.714248 0.146 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 0.714248 0.146 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.714248 0.146 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.714248 0.146 0 0
Interleukin-27 signaling R-HSA-9020956 0.714248 0.146 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.714248 0.146 0 0
RNA Polymerase I Transcription R-HSA-73864 0.720683 0.142 0 0
PCP/CE pathway R-HSA-4086400 0.720683 0.142 0 0
Toll-like Receptor Cascades R-HSA-168898 0.721447 0.142 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.722872 0.141 0 0
Signaling by FGFR4 R-HSA-5654743 0.722872 0.141 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.722872 0.141 0 0
Homology Directed Repair R-HSA-5693538 0.723965 0.140 0 0
G-protein beta:gamma signalling R-HSA-397795 0.724336 0.140 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.724336 0.140 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.724336 0.140 0 0
Signaling by ROBO receptors R-HSA-376176 0.727761 0.138 0 0
tRNA processing R-HSA-72306 0.730538 0.136 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.732985 0.135 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.732985 0.135 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.732985 0.135 0 0
Base Excision Repair R-HSA-73884 0.735797 0.133 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.736621 0.133 0 0
RMTs methylate histone arginines R-HSA-3214858 0.736621 0.133 0 0
Transcription of the HIV genome R-HSA-167172 0.738935 0.131 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.739872 0.131 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.740508 0.130 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 0.740508 0.130 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 0.740508 0.130 0 0
vRNA Synthesis R-HSA-192814 0.740508 0.130 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.740508 0.130 0 0
Synthesis of PI R-HSA-1483226 0.740508 0.130 0 0
Chylomicron assembly R-HSA-8963888 0.740508 0.130 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.741976 0.130 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.749848 0.125 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.749848 0.125 0 0
Signaling by FGFR3 R-HSA-5654741 0.749848 0.125 0 0
DAG and IP3 signaling R-HSA-1489509 0.749848 0.125 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.749848 0.125 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.749848 0.125 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.751043 0.124 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.751043 0.124 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.751043 0.124 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.751043 0.124 0 0
Signaling by KIT in disease R-HSA-9669938 0.751043 0.124 0 0
LDL clearance R-HSA-8964038 0.751043 0.124 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.754704 0.122 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.754704 0.122 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.754704 0.122 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.754704 0.122 0 0
PI Metabolism R-HSA-1483255 0.758470 0.120 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.760461 0.119 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.760621 0.119 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.762079 0.118 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.762560 0.118 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.762560 0.118 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.762560 0.118 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.764356 0.117 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.764356 0.117 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.764356 0.117 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.764356 0.117 0 0
Signaling by Insulin receptor R-HSA-74752 0.764393 0.117 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.765627 0.116 1 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.768039 0.115 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.768039 0.115 0 0
Interleukin-20 family signaling R-HSA-8854691 0.768039 0.115 0 0
Organic anion transport by SLCO transporters R-HSA-879518 0.768039 0.115 0 0
Formation of the ureteric bud R-HSA-9830674 0.768039 0.115 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.768847 0.114 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.768847 0.114 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.768847 0.114 0 0
Regulation of Apoptosis R-HSA-169911 0.768847 0.114 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.770954 0.113 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.770954 0.113 0 0
Extension of Telomeres R-HSA-180786 0.771638 0.113 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.771638 0.113 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.777453 0.109 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.780950 0.107 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.781064 0.107 0 0
SLC transporter disorders R-HSA-5619102 0.781317 0.107 0 0
HSF1 activation R-HSA-3371511 0.782316 0.107 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.782316 0.107 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.782316 0.107 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.782316 0.107 0 0
RSV-host interactions R-HSA-9833110 0.783970 0.106 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.784015 0.106 0 0
Complex III assembly R-HSA-9865881 0.784015 0.106 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.784015 0.106 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.784015 0.106 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.784015 0.106 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 0.784015 0.106 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.786014 0.105 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.786014 0.105 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.786014 0.105 0 0
Regulation of IFNG signaling R-HSA-877312 0.786014 0.105 0 0
Leading Strand Synthesis R-HSA-69109 0.786014 0.105 0 0
Polymerase switching R-HSA-69091 0.786014 0.105 0 0
OAS antiviral response R-HSA-8983711 0.786014 0.105 0 0
Interleukin-35 Signalling R-HSA-8984722 0.786014 0.105 0 0
GPER1 signaling R-HSA-9634597 0.786466 0.104 0 0
Cellular response to chemical stress R-HSA-9711123 0.788762 0.103 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.790701 0.102 0 0
HCMV Late Events R-HSA-9610379 0.790887 0.102 0 0
PLC beta mediated events R-HSA-112043 0.792789 0.101 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.799015 0.097 0 0
Long-term potentiation R-HSA-9620244 0.799015 0.097 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.799015 0.097 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.799015 0.097 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.799015 0.097 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.799015 0.097 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.802774 0.095 0 0
Signaling by PDGF R-HSA-186797 0.802774 0.095 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 0.805682 0.094 0 0
Chylomicron remodeling R-HSA-8963901 0.805682 0.094 0 0
FGFR1c ligand binding and activation R-HSA-190373 0.805682 0.094 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.805682 0.094 0 0
Interleukin-6 signaling R-HSA-1059683 0.805682 0.094 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.805682 0.094 0 0
Processing of SMDT1 R-HSA-8949664 0.805682 0.094 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.805682 0.094 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.806988 0.093 0 0
HCMV Infection R-HSA-9609646 0.812002 0.090 0 0
TRP channels R-HSA-3295583 0.813084 0.090 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.813084 0.090 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.813084 0.090 0 0
Metalloprotease DUBs R-HSA-5689901 0.813084 0.090 0 0
Telomere Maintenance R-HSA-157579 0.814763 0.089 0 0
Interleukin-12 family signaling R-HSA-447115 0.815570 0.089 0 0
Interleukin-12 signaling R-HSA-9020591 0.817644 0.087 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.818871 0.087 0 0
Stabilization of p53 R-HSA-69541 0.818871 0.087 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.818871 0.087 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.823256 0.084 0 0
Removal of the Flap Intermediate R-HSA-69166 0.823544 0.084 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 0.823544 0.084 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.823544 0.084 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 0.823544 0.084 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.826266 0.083 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.826266 0.083 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.826266 0.083 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.826266 0.083 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.828479 0.082 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.828479 0.082 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.828479 0.082 0 0
SARS-CoV Infections R-HSA-9679506 0.829659 0.081 1 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.829836 0.081 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.829836 0.081 0 0
HIV Transcription Elongation R-HSA-167169 0.829836 0.081 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.829836 0.081 0 0
Generation of second messenger molecules R-HSA-202433 0.829836 0.081 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.829836 0.081 0 0
Smooth Muscle Contraction R-HSA-445355 0.837841 0.077 0 0
Meiotic synapsis R-HSA-1221632 0.837841 0.077 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.838605 0.076 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.838605 0.076 0 0
Telomere Extension By Telomerase R-HSA-171319 0.838605 0.076 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.838605 0.076 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.838605 0.076 0 0
Pyroptosis R-HSA-5620971 0.838605 0.076 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.839765 0.076 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.839765 0.076 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.839765 0.076 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.839765 0.076 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.839765 0.076 0 0
Signaling by Activin R-HSA-1502540 0.839765 0.076 0 0
p38MAPK events R-HSA-171007 0.839765 0.076 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.839765 0.076 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.839765 0.076 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.839765 0.076 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.839765 0.076 0 0
Protein methylation R-HSA-8876725 0.839765 0.076 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.839765 0.076 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.840227 0.076 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.840227 0.076 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.842243 0.075 0 0
Translation initiation complex formation R-HSA-72649 0.846770 0.072 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.847086 0.072 0 0
DNA Double Strand Break Response R-HSA-5693606 0.847086 0.072 0 0
G-protein mediated events R-HSA-112040 0.847086 0.072 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.847972 0.072 1 0
Degradation of CRY and PER proteins R-HSA-9932298 0.850064 0.071 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.850064 0.071 0 0
Intra-Golgi traffic R-HSA-6811438 0.850064 0.071 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.850145 0.071 0 0
mRNA Capping R-HSA-72086 0.850145 0.071 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.850145 0.071 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.850145 0.071 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.850145 0.071 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.850145 0.071 0 0
Platelet calcium homeostasis R-HSA-418360 0.850145 0.071 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.854495 0.068 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.854495 0.068 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.854495 0.068 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 0.854495 0.068 0 0
Regulation of BACH1 activity R-HSA-9708530 0.854495 0.068 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.854495 0.068 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.854495 0.068 0 0
Negative regulation of FLT3 R-HSA-9706369 0.854495 0.068 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.854698 0.068 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.855280 0.068 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.856480 0.067 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.859370 0.066 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.860927 0.065 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.862597 0.064 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.863385 0.064 0 0
Ion homeostasis R-HSA-5578775 0.863385 0.064 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.867872 0.062 0 0
Phase 2 - plateau phase R-HSA-5576893 0.867872 0.062 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.867872 0.062 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 0.867872 0.062 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 0.867872 0.062 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.867872 0.062 0 0
Integration of energy metabolism R-HSA-163685 0.869354 0.061 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.869985 0.060 0 0
Budding and maturation of HIV virion R-HSA-162588 0.870995 0.060 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.870995 0.060 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.871742 0.060 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.874374 0.058 0 0
Hedgehog 'on' state R-HSA-5632684 0.876306 0.057 0 0
Gap junction trafficking R-HSA-190828 0.876470 0.057 0 0
DAP12 interactions R-HSA-2172127 0.876470 0.057 0 0
Amine ligand-binding receptors R-HSA-375280 0.876470 0.057 0 0
Dual incision in TC-NER R-HSA-6782135 0.878432 0.056 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.880020 0.056 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.880020 0.056 0 0
Glycogen storage diseases R-HSA-3229121 0.880020 0.056 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.880020 0.056 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.880020 0.056 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.880020 0.056 0 0
Choline catabolism R-HSA-6798163 0.880020 0.056 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.880388 0.055 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.884308 0.053 0 0
Somitogenesis R-HSA-9824272 0.884308 0.053 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.884308 0.053 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.888799 0.051 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.888799 0.051 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.889145 0.051 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.889145 0.051 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.889145 0.051 0 0
Stimuli-sensing channels R-HSA-2672351 0.890226 0.050 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.891052 0.050 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.891052 0.050 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.891052 0.050 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 0.891052 0.050 0 0
Platelet sensitization by LDL R-HSA-432142 0.891052 0.050 0 0
GAB1 signalosome R-HSA-180292 0.891052 0.050 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.897304 0.047 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.897304 0.047 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.898663 0.046 0 0
Signaling by FGFR R-HSA-190236 0.899078 0.046 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.900635 0.045 0 0
Protein ubiquitination R-HSA-8852135 0.900635 0.045 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.900635 0.045 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.901070 0.045 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.901070 0.045 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.901070 0.045 0 0
Pyrimidine biosynthesis R-HSA-500753 0.901070 0.045 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.901070 0.045 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.901070 0.045 0 0
Other interleukin signaling R-HSA-449836 0.901070 0.045 0 0
HDL remodeling R-HSA-8964058 0.901070 0.045 0 0
The NLRP3 inflammasome R-HSA-844456 0.901070 0.045 0 0
Chromosome Maintenance R-HSA-73886 0.901332 0.045 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.904258 0.044 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.904900 0.043 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.904900 0.043 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.904900 0.043 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.904900 0.043 0 0
Hyaluronan metabolism R-HSA-2142845 0.904900 0.043 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.904900 0.043 0 0
Influenza Infection R-HSA-168255 0.905637 0.043 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.909790 0.041 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.910167 0.041 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.910167 0.041 0 0
Glycogen synthesis R-HSA-3322077 0.910167 0.041 0 0
Signaling by NODAL R-HSA-1181150 0.910167 0.041 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.910167 0.041 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.910167 0.041 0 0
Nephrin family interactions R-HSA-373753 0.910167 0.041 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.911968 0.040 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.911968 0.040 0 0
Adaptive Immune System R-HSA-1280218 0.914380 0.039 0 0
Interleukin-10 signaling R-HSA-6783783 0.916046 0.038 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.918287 0.037 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.918429 0.037 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.918429 0.037 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.918429 0.037 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 0.918429 0.037 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.918429 0.037 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.918542 0.037 0 0
GPVI-mediated activation cascade R-HSA-114604 0.918542 0.037 0 0
Glycosphingolipid transport R-HSA-9845576 0.918542 0.037 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.919933 0.036 0 0
Degradation of AXIN R-HSA-4641257 0.924651 0.034 0 0
Signaling by FGFR2 R-HSA-5654738 0.925113 0.034 0 0
Neddylation R-HSA-8951664 0.925636 0.034 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.925931 0.033 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.925931 0.033 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.925931 0.033 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.925931 0.033 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.925931 0.033 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 0.925931 0.033 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.925931 0.033 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.930326 0.031 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.930326 0.031 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.930326 0.031 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.930326 0.031 0 0
FGFR2 alternative splicing R-HSA-6803529 0.932743 0.030 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.932743 0.030 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.932743 0.030 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.933912 0.030 0 0
Regulated Necrosis R-HSA-5218859 0.933912 0.030 0 0
Muscle contraction R-HSA-397014 0.934044 0.030 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.934044 0.030 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.935595 0.029 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.935595 0.029 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.937084 0.028 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.937103 0.028 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.937820 0.028 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.938929 0.027 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.938929 0.027 0 0
Syndecan interactions R-HSA-3000170 0.938929 0.027 0 0
Developmental Cell Lineages R-HSA-9734767 0.938933 0.027 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.939813 0.027 0 0
Diseases of Immune System R-HSA-5260271 0.940484 0.027 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.940484 0.027 0 0
Glycogen metabolism R-HSA-8982491 0.940484 0.027 0 0
Reproduction R-HSA-1474165 0.940632 0.027 0 0
G alpha (z) signalling events R-HSA-418597 0.941337 0.026 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.941582 0.026 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.941771 0.026 0 0
Meiosis R-HSA-1500620 0.944081 0.025 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 0.944547 0.025 0 0
Interleukin-6 family signaling R-HSA-6783589 0.944547 0.025 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.944547 0.025 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 0.944547 0.025 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.944547 0.025 0 0
Plasma lipoprotein assembly R-HSA-8963898 0.944547 0.025 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.945020 0.025 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.945020 0.025 0 0
TCR signaling R-HSA-202403 0.948044 0.023 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.948630 0.023 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.948768 0.023 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.949225 0.023 0 0
Translation of Structural Proteins R-HSA-9683701 0.949225 0.023 1 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 0.949648 0.022 0 0
G protein gated Potassium channels R-HSA-1296059 0.949648 0.022 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 0.949648 0.022 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.949648 0.022 0 0
Tight junction interactions R-HSA-420029 0.949648 0.022 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.949648 0.022 0 0
Hyaluronan degradation R-HSA-2160916 0.949648 0.022 0 0
Formation of the nephric duct R-HSA-9830364 0.949648 0.022 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.949648 0.022 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.949648 0.022 0 0
MHC class II antigen presentation R-HSA-2132295 0.951908 0.021 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.952997 0.021 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.953122 0.021 0 0
Depyrimidination R-HSA-73928 0.953122 0.021 0 0
Pyruvate metabolism R-HSA-70268 0.953263 0.021 0 0
MET activates PTK2 signaling R-HSA-8874081 0.954280 0.020 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.954280 0.020 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.954280 0.020 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.954280 0.020 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.954280 0.020 0 0
Signaling by ERBB4 R-HSA-1236394 0.954986 0.020 0 0
Hedgehog 'off' state R-HSA-5610787 0.955467 0.020 0 0
Defective pyroptosis R-HSA-9710421 0.956732 0.019 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.956732 0.019 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.956732 0.019 1 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.958098 0.019 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.958487 0.018 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 0.958487 0.018 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.958487 0.018 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 0.958487 0.018 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.958487 0.018 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.958487 0.018 0 0
Insulin processing R-HSA-264876 0.958487 0.018 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.958929 0.018 0 0
Proteasome assembly R-HSA-9907900 0.960074 0.018 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.962306 0.017 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.962306 0.017 0 0
Pyrimidine salvage R-HSA-73614 0.962306 0.017 0 0
Inflammasomes R-HSA-622312 0.962306 0.017 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.963169 0.016 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.964749 0.016 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.965385 0.015 0 0
Cholesterol biosynthesis R-HSA-191273 0.965385 0.015 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.965493 0.015 0 0
Leishmania phagocytosis R-HSA-9664417 0.965493 0.015 0 0
Parasite infection R-HSA-9664407 0.965493 0.015 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 0.965774 0.015 0 0
DNA methylation R-HSA-5334118 0.965774 0.015 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.966032 0.015 0 0
Diseases of DNA repair R-HSA-9675135 0.966032 0.015 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.966364 0.015 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.966364 0.015 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.966808 0.015 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.967611 0.014 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.967632 0.014 0 0
Synthesis of PC R-HSA-1483191 0.968680 0.014 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.968924 0.014 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.968924 0.014 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.968924 0.014 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.969702 0.013 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.971129 0.013 0 0
Cardiac conduction R-HSA-5576891 0.971557 0.013 0 0
Cargo concentration in the ER R-HSA-5694530 0.971783 0.012 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.972948 0.012 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.973817 0.012 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.974380 0.011 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.974380 0.011 0 0
Interferon gamma signaling R-HSA-877300 0.975103 0.011 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.975484 0.011 0 0
Azathioprine ADME R-HSA-9748787 0.975484 0.011 0 0
Cardiogenesis R-HSA-9733709 0.976738 0.010 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 0.977416 0.010 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.977416 0.010 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.977416 0.010 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.977978 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.978879 0.009 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.979200 0.009 0 0
COPII-mediated vesicle transport R-HSA-204005 0.980146 0.009 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.980146 0.009 0 0
eNOS activation R-HSA-203615 0.980823 0.008 0 0
Gap junction assembly R-HSA-190861 0.980823 0.008 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.980823 0.008 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.980823 0.008 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 0.980823 0.008 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.980823 0.008 0 0
Signal amplification R-HSA-392518 0.980823 0.008 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.980848 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.982588 0.008 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.982588 0.008 0 0
Platelet degranulation R-HSA-114608 0.983042 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.984191 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.984191 0.007 0 0
ER-Phagosome pathway R-HSA-1236974 0.984693 0.007 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.984743 0.007 0 0
Interferon alpha/beta signaling R-HSA-909733 0.984743 0.007 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.985065 0.007 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.985647 0.006 0 0
Cleavage of the damaged purine R-HSA-110331 0.985647 0.006 0 0
NCAM1 interactions R-HSA-419037 0.985647 0.006 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.985647 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 0.985647 0.006 0 0
Collagen chain trimerization R-HSA-8948216 0.985647 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 0.985724 0.006 0 0
Downstream TCR signaling R-HSA-202424 0.985724 0.006 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.985901 0.006 0 0
Opioid Signalling R-HSA-111885 0.985901 0.006 0 0
Synthesis of PA R-HSA-1483166 0.986259 0.006 0 0
tRNA processing in the mitochondrion R-HSA-6785470 0.986968 0.006 0 0
Depurination R-HSA-73927 0.986968 0.006 0 0
Purine salvage R-HSA-74217 0.986968 0.006 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 0.986968 0.006 0 0
Cellular response to starvation R-HSA-9711097 0.987413 0.006 0 0
Pentose phosphate pathway R-HSA-71336 0.988168 0.005 0 0
Translation of Structural Proteins R-HSA-9694635 0.988270 0.005 1 0
Peroxisomal protein import R-HSA-9033241 0.988373 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.988373 0.005 0 0
Platelet homeostasis R-HSA-418346 0.988432 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.989223 0.005 0 0
rRNA processing in the mitochondrion R-HSA-8868766 0.989257 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 0.989257 0.005 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.989257 0.005 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.989308 0.005 0 0
Metabolism of polyamines R-HSA-351202 0.989308 0.005 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.989308 0.005 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.990247 0.004 0 0
Maturation of spike protein R-HSA-9694548 0.990247 0.004 0 0
Transmission across Chemical Synapses R-HSA-112315 0.990318 0.004 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.991145 0.004 0 0
GABA B receptor activation R-HSA-977444 0.991960 0.004 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.991960 0.004 0 0
Activation of GABAB receptors R-HSA-991365 0.991960 0.004 0 0
Signaling by Hedgehog R-HSA-5358351 0.992234 0.003 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.992367 0.003 0 0
Regulation of insulin secretion R-HSA-422356 0.992980 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.993373 0.003 0 0
Surfactant metabolism R-HSA-5683826 0.993373 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 0.993924 0.003 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.993967 0.003 0 0
Nucleosome assembly R-HSA-774815 0.993983 0.003 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.993983 0.003 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.994538 0.002 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.994538 0.002 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.994538 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.994538 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.994905 0.002 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.995030 0.002 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 0.995041 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 0.995205 0.002 0 0
Intraflagellar transport R-HSA-5620924 0.995498 0.002 0 0
Gluconeogenesis R-HSA-70263 0.995498 0.002 0 0
Metal ion SLC transporters R-HSA-425410 0.995498 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.995791 0.002 0 0
Metabolism of cofactors R-HSA-8978934 0.995791 0.002 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.995913 0.002 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.996618 0.001 0 0
Meiotic recombination R-HSA-912446 0.996631 0.001 0 0
Complex IV assembly R-HSA-9864848 0.996631 0.001 0 0
The phototransduction cascade R-HSA-2514856 0.996631 0.001 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.996860 0.001 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.996860 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.996860 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.996867 0.001 1 0
Phospholipid metabolism R-HSA-1483257 0.996958 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.997014 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 0.997057 0.001 0 0
Protein localization R-HSA-9609507 0.997169 0.001 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.997223 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 0.997223 0.001 0 0
Hemostasis R-HSA-109582 0.997525 0.001 0 0
ABC transporter disorders R-HSA-5619084 0.997695 0.001 0 0
Paracetamol ADME R-HSA-9753281 0.997712 0.001 0 0
G alpha (s) signalling events R-HSA-418555 0.997715 0.001 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.997720 0.001 0 0
Ion channel transport R-HSA-983712 0.998055 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.998207 0.001 0 0
Amyloid fiber formation R-HSA-977225 0.998222 0.001 0 0
Metabolism of steroids R-HSA-8957322 0.998573 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 0.998589 0.001 0 0
GABA receptor activation R-HSA-977443 0.998589 0.001 0 0
tRNA Aminoacylation R-HSA-379724 0.998589 0.001 0 0
Nucleotide salvage R-HSA-8956321 0.998719 0.001 0 0
Collagen degradation R-HSA-1442490 0.998719 0.001 0 0
Mitochondrial protein import R-HSA-1268020 0.998837 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.998945 0.000 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.998985 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 0.999042 0.000 0 0
Neuronal System R-HSA-112316 0.999079 0.000 0 0
rRNA processing R-HSA-72312 0.999142 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.999210 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.999349 0.000 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.999470 0.000 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.999470 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 0.999513 0.000 0 0
Collagen formation R-HSA-1474290 0.999521 0.000 0 0
Viral Infection Pathways R-HSA-9824446 0.999537 0.000 1 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.999586 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.999599 0.000 0 0
Potassium Channels R-HSA-1296071 0.999633 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 0.999636 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.999636 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999717 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.999718 0.000 0 0
Integrin cell surface interactions R-HSA-216083 0.999753 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.999815 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.999862 0.000 0 0
Leishmania infection R-HSA-9658195 0.999890 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 0.999890 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.999903 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 0.999915 0.000 0 0
Immune System R-HSA-168256 0.999935 0.000 0 0
Post-translational protein modification R-HSA-597592 0.999938 0.000 0 0
FCGR activation R-HSA-2029481 0.999952 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 0.999960 0.000 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.999964 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.999968 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.999970 0.000 1 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.999973 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999975 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.999978 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.999991 0.000 0 0
Metabolism of nucleotides R-HSA-15869 0.999993 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999993 0.000 0 0
Antimicrobial peptides R-HSA-6803157 0.999993 0.000 0 0
Keratinization R-HSA-6805567 0.999996 0.000 0 0
Visual phototransduction R-HSA-2187338 0.999998 0.000 0 0
Neutrophil degranulation R-HSA-6798695 0.999998 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.999999 0.000 0 0
Nucleotide catabolism R-HSA-8956319 0.999999 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999999 0.000 0 0
Sensory perception of taste R-HSA-9717189 0.999999 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 0.999999 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.999999 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 0.999999 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Translation R-HSA-72766 1.000000 0.000 0 0
Extracellular matrix organization R-HSA-1474244 1.000000 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 1.000000 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.000000 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.000000 0.000 0 0
Disease R-HSA-1643685 1.000000 0.000 1 0
G alpha (i) signalling events R-HSA-418594 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 1 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
Infectious disease R-HSA-5663205 1.000000 0.000 1 0
Innate Immune System R-HSA-168249 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways