GRK5

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00115 S57 Sugiyama DNASE2 DNASE2A DNL2 ALRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGR
O00170 S43 Sugiyama AIP XAP2 GELPDFQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELI
O00592 T556 Sugiyama PODXL PCLP PCLP1 DsWIVPLDNLTKDDLDEEEDtHL__________________
O43615 S94 Sugiyama TIMM44 MIMT44 TIM44 NKEMKESIKKFRDEARRLEEsDVLQEARRKyKtIESETVRT
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60264 S825 Sugiyama SMARCA5 SNF2H WCRF135 ELPNAAQAQKEEQLKIDEAEsLNDEELEEKEKLLTQGFTNW
O60353 S648 PSP FZD6 LsGEQVDGKGQAGsVSESARsEGRIsPKsDItDtGLAQSNN
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60832 S453 Sugiyama DKC1 NOLA4 KAPQVVAEAAKTAKRKREsEsEsDEtPPAAPQLIKKEKKKS
O60841 S113 Sugiyama EIF5B IF2 KIAA0741 sKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTAKPKVEM
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75581 S1490 GPS6|EPSD LRP6 SSSSssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPs
O76070 S124 iPTMNet|EPSD SNCG BCSG1 PERSYN PRSN APQQEGEAsKEKEEVAEEAQsGGD_________________
O95155 S118 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 QsLsRsQsMDIDGVSCEKsMsQVDVDsGIENMEVDENDRRE
O95218 S188 Sugiyama ZRANB2 ZIS ZNF265 KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95757 S508 Sugiyama HSPA4L APG1 HSPH3 OSP94 GIFSVASASVIEKQNLEGDHsDAPMETEtsFKNENKDNMDK
O95816 S208 Sugiyama BAG2 IKLLEHSKGAGSKTLQQNAEsRFN_________________
P02786 S151 Sugiyama TFRC LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04080 T96 Sugiyama CSTB CST6 STFB ENKPLtLsNyQTNKAKHDELtyF__________________
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083 S201 Sugiyama ANXA1 ANX1 LPC1 LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04637 T55 GPS6|SIGNOR|EPSD|PSP TP53 P53 LPsQAMDDLMLsPDDIEQWFtEDPGPDEAPRMPEAAPPVAP
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05187 S434 Sugiyama ALPP PLAP LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDEETH
P05198 T279 Sugiyama EIF2S1 EIF2A KEKIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAE
P05198 T281 Sugiyama EIF2S1 EIF2A KIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVD
P05198 T284 Sugiyama EIF2S1 EIF2A EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05556 S509 Sugiyama ITGB1 FNRB MDF2 MSK12 CRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSEICSNNG
P05787 S475 Sugiyama KRT8 CYK8 TSSSRAVVVKKIETRDGKLVsEssDVLPK____________
P05787 S477 Sugiyama KRT8 CYK8 SSRAVVVKKIETRDGKLVsEssDVLPK______________
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07550 S355 EPSD|PSP ADRB2 ADRB2R B2AR AFQELLCLRRssLKAyGNGyssNGNtGEQsGYHVEQEKENK
P07550 S356 EPSD|PSP ADRB2 ADRB2R B2AR FQELLCLRRssLKAyGNGyssNGNtGEQsGYHVEQEKENKL
P07550 S396 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ADRB2 ADRB2R B2AR LLCEDLPGtEDFVGHQGtVPsDNIDsQGRNCstNDsLL___
P07550 S401 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ADRB2 ADRB2R B2AR LPGtEDFVGHQGtVPsDNIDsQGRNCstNDsLL________
P07550 S407 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ADRB2 ADRB2R B2AR FVGHQGtVPsDNIDsQGRNCstNDsLL______________
P07550 S411 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ADRB2 ADRB2R B2AR QGtVPsDNIDsQGRNCstNDsLL__________________
P07550 T384 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ADRB2 ADRB2R B2AR sGYHVEQEKENKLLCEDLPGtEDFVGHQGtVPsDNIDsQGR
P07550 T393 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ADRB2 ADRB2R B2AR ENKLLCEDLPGtEDFVGHQGtVPsDNIDsQGRNCstNDsLL
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07900 S164 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGT
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08195 T106 Sugiyama SLC3A2 MDU1 SDPPALASKNAEVTGTMsQDtEVDMKEVELNELEPEKQPMN
P08238 S159 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB VAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGT
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P0CAP2 S365 Sugiyama POLR2M GRINL1A PEGESSGRYREVRDEDDDWssDEF_________________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 S54 Sugiyama TUBA3C TUBA2 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10696 S431 Sugiyama ALPG ALPPL ALPPL2 LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDGETH
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11387 S10 Sugiyama TOP1 ___________MsGDHLHNDsQIEADFRLNDsHKHKDKHKD
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13667 S468 Sugiyama PDIA4 ERP70 ERP72 ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13798 S185 Sugiyama APEH D3F15S2 D3S48E DNF15S2 VAEKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQ
P14618 T195 Sugiyama PKM OIP3 PK2 PK3 PKM2 yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P14625 T522 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 NRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMA
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15927 S257 Sugiyama RPA2 REPA2 RPA32 RPA34 MsVsSIKQAVDFLSNEGHIysTVDDDHFKSTDAE_______
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17096 S103 Sugiyama HMGA1 HMGIY PRGRPKKLEKEEEEGIsQEssEEEQ________________
P17812 S578 Sugiyama CTPS1 CTPS GCRLsPRDtysDRsGsssPDsEItELKFPsINHD_______
P17844 S519 Sugiyama DDX5 G17P1 HELR HLR1 AGKRGGFNTFRDRENYDRGYssLLKRDFGAKTQNGVYSAAN
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P17987 Y545 Sugiyama TCP1 CCT1 CCTA LRIDDLIKLHPESKDDKHGsyEDAVHsGALND_________
P19338 S356 Sugiyama NCL LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P19338 T583 Sugiyama NCL sPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTD
P20042 S105 Sugiyama EIF2S2 EIF2B TKKIFDIDEAEEGVKDLKIEsDVQEPtEPEDDLDIMLGNKK
P20042 T33 Sugiyama EIF2S2 EIF2B sKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtEDKD
P20810 S373 Sugiyama CAST LPEPEEKPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTE
P21127 S277 Sugiyama CDK11B CDC2L1 CDK11 PITSLREA PK58 APAQKPAQLKEEKMEERDLLsDLQDIsDsERKTSSAESSSA
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23246 S521 Sugiyama SFPQ PSF EKQQREQVEKNMKDAKDKLEsEMEDAyHEHQANLLRQDLMR
P23396 S209 Sugiyama RPS3 OK/SW-cl.26 MLPWDPTGKIGPKKPLPDHVsIVEPKDEILPttPIsEQKGG
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23921 T774 Sugiyama RRM1 RR1 KEKLKDKEKVSKEEEEKERNtAAMVCsLENRDECLMCGS__
P25205 S704 Sugiyama MCM3 DQEQKRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPK
P25205 S711 Sugiyama MCM3 RRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADsQEt
P25205 T713 Sugiyama MCM3 KTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADsQEtKE
P25205 Y708 Sugiyama MCM3 KRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADs
P25705 T64 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM QKtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARV
P25788 S250 Sugiyama PSMA3 HC8 PSC8 KDIREEAEKyAKEsLKEEDEsDDDNM_______________
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T66 PSP MSN GLQYQDTKGFSTWLKLNKKVtAQDVRKEsPLLFKFRAKFyP
P26196 S475 Sugiyama DDX6 HLR2 RCK TEIKPIPsNIDKSLyVAEyHsEPVEDEKP____________
P27348 S145 Sugiyama YWHAQ YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797 S189 Sugiyama CALR CRTC THLytLIVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIK
P27797 S193 Sugiyama CALR CRTC tLIVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDA
P27797 S214 Sugiyama CALR CRTC GsLEDDWDFLPPKKIKDPDAsKPEDWDERAKIDDPtDsKPE
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692 S71 Sugiyama EEF1D EF1D ARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVEN
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30411 S366 SIGNOR|iPTMNet|EPSD BDKRB2 BKR2 VyQGVCQKGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDW
P30411 S373 SIGNOR|iPTMNet|EPSD BDKRB2 BKR2 KGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ__
P30411 S375 SIGNOR|iPTMNet|EPSD BDKRB2 BKR2 GCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ____
P30533 T248 Sugiyama LRPAP1 A2MRAP LRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSAN
P31327 S898 Sugiyama CPS1 LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31327 T900 Sugiyama CPS1 KMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQISKC
P33993 S314 Sugiyama MCM7 CDC47 MCM2 SETyLEAHRIVKMNKSEDDEsGAGELtREELRQIAEEDFyE
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34947 S484 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama GRK5 GPRK5 PFVPDPRAVYCKDVLDIEQFstVKGVNLDHtDDDFYSKFST
P34947 S589 Sugiyama GRK5 GPRK5 SKtsFNHHINSNHVSsNstGss___________________
P34947 S590 Sugiyama GRK5 GPRK5 KtsFNHHINSNHVSsNstGss____________________
P34947 T10 PSP GRK5 GPRK5 ___________MELENIVANtVLLKAREGGGGKRKGKSKKW
P34947 T485 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama GRK5 GPRK5 FVPDPRAVYCKDVLDIEQFstVKGVNLDHtDDDFYSKFSTG
P34947 T494 Sugiyama GRK5 GPRK5 CKDVLDIEQFstVKGVNLDHtDDDFYSKFSTGSVSIPWQNE
P35221 T645 Sugiyama CTNNA1 IRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDDQLIA
P35579 S1308 Sugiyama MYH9 LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P35659 S227 Sugiyama DEK ERNsSGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDE
P35659 S230 Sugiyama DEK sSGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKE
P36578 S55 Sugiyama RPL4 RPL1 DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37840 S129 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SNCA NACP PARK1 QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40925 T225 Sugiyama MDH1 MDHA KEVGVyEALKDDsWLKGEFVttVQQRGAAVIKARKLssAMS
P41227 S216 Sugiyama NAA10 ARD1 ARD1A TE2 EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P43003 S512 Sugiyama SLC1A3 EAAT1 GLAST GLAST1 GIVEHLSRHELKNRDVEMGNsVIEENEMKKPyQLIAQDNET
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43250 S484 Sugiyama GRK6 GPRK6 PFKPDPQAIYCKDVLDIEQFstVKGVELEPTDQDFYQKFAT
P43250 T485 Sugiyama GRK6 GPRK6 FKPDPQAIYCKDVLDIEQFstVKGVELEPTDQDFYQKFATG
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P45974 S783 Sugiyama USP5 ISOT IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P48643 T269 Sugiyama CCT5 CCTE KIAA0098 AILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMI
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49321 S176 Sugiyama NASP EAKKTEDKSLAKPEtDKEQDsEMEKGGREDMDIsKsAEEPQ
P49321 S497 Sugiyama NASP tEGsEEDDKENDKtEEMPNDsVLENKsLQENEEEEIGNLEL
P49321 T207 Sugiyama NASP DIsKsAEEPQEKVDLtLDWLtEtsEEAKGGAAPEGPNEAEV
P49407 S412 GPS6|EPSD ARRB1 ARR1 ARQRLKGMKDDKEEEEDGtGsPQLNNR______________
P49792 S2493 Sugiyama RANBP2 NUP358 EEtTRERTDVIQGDDVADAtsEVEVsstSEttPKAVVsPPK
P49792 S2498 Sugiyama RANBP2 NUP358 ERTDVIQGDDVADAtsEVEVsstSEttPKAVVsPPKFVFGs
P50502 S346 GPS6|SIGNOR|EPSD|PSP ST13 AAG2 FAM10A1 HIP SNC6 MQDPEVMVAFQDVAQNPANMsKYQSNPKVMNLISKLSAKFG
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P51858 T225 Sugiyama HDGF HMG1L2 GsGRGPPQEEEEEEDEEEEAtKEDAEAPGIRDHEsL_____
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S457 Sugiyama ACLY FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55036 S266 Sugiyama PSMD4 MCB1 AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P55081 S118 Sugiyama MFAP1 EERLARHRKIVEPEVVGEsDsEVEGDAWRMEREDssEEEEE
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T202 Sugiyama ACTB GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S263 Sugiyama RPS3A FTE1 MFTL GDEtGAKVERADGyEPPVQEsV___________________
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62241 S4 Sugiyama RPS8 OK/SW-cl.83 _________________MGIsRDNWHKRRKTGGKRKPYHKK
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T202 Sugiyama ACTG1 ACTG GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 S54 Sugiyama TUBA1B GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P78371 S470 Sugiyama CCT2 99D8.1 CCTB IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00839 S59 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02878 T235 Sugiyama RPL6 TXREB1 AyFKKKKLRKPRHQEGEIFDtEKEKYEITEQRKIDQKAVDs
Q04917 T31 Sugiyama YWHAH YWHA1 ARLAEQAERyDDMAsAMKAVtELNEPLsNEDRNLLsVAyKN
Q05519 Y425 Sugiyama SRSF11 SFRS11 EKDRERKSEsDKDVKQVtRDyDEEEQGYDsEKEKKEEKKPI
Q07021 S201 Sugiyama C1QBP GC1QBP HABP1 SF2P32 ALVLDCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKD
Q07021 S213 Sugiyama C1QBP GC1QBP HABP1 SF2P32 VGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDW
Q07021 S87 Sugiyama C1QBP GC1QBP HABP1 SF2P32 CGCGCGSLHTDGDKAFVDFLsDEIKEERKIQKHKTLPKMsG
Q08945 S437 Sugiyama SSRP1 FACT80 FVNAKKLNIKNRGLKEGMNPsyDEyADsDEDQHDAYLERMK
Q08945 S444 Sugiyama SSRP1 FACT80 NIKNRGLKEGMNPsyDEyADsDEDQHDAYLERMKEEGKIRE
Q08945 Y438 Sugiyama SSRP1 FACT80 VNAKKLNIKNRGLKEGMNPsyDEyADsDEDQHDAYLERMKE
Q12792 T348 Sugiyama TWF1 PTK9 GPAGKRGIRRLIRGPAEtEAttD__________________
Q12792 T349 Sugiyama TWF1 PTK9 PAGKRGIRRLIRGPAEtEAttD___________________
Q12874 S482 Sugiyama SF3A3 SAP61 LKLQKASERWQPDtEEEyEDssGNVVNKKTYEDLKRQGLL_
Q13185 S176 Sugiyama CBX3 ANMKCPQIVIAFYEERLtWHsCPEDEAQ_____________
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283 T143 Sugiyama G3BP1 G3BP KFyVHNDIFRyQDEVFGGFVtEPQEEsEEEVEEPEERQQtP
Q13435 S289 Sugiyama SF3B2 SAP145 IPQALEKILQLKESRQEEMNsQQEEEEMETDARssLGQsAs
Q13435 S309 Sugiyama SF3B2 SAP145 sQQEEEEMETDARssLGQsAsEtEEDtVsVsKKEKNRKRRN
Q13451 S445 Sugiyama FKBP5 AIG6 FKBP51 ANKAMGKKTSEGVTNEKGtDsQAMEEEKPEGHV________
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13547 S423 Sugiyama HDAC1 RPD3L1 KRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAKRV
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14203 S417 Sugiyama DCTN1 KKNQELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAE
Q14444 T303 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14568 S164 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGT
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14978 S637 Sugiyama NOLC1 KIAA0035 NS5ATP13 GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q15084 S428 Sugiyama PDIA6 ERP5 P5 TXNDC7 EREPWDGRDGELPVEDDIDLsDVELDDLGKDEL________
Q15527 T195 Sugiyama SURF2 LFTRKDLGstEDGDGtDDFLtDKEDEKAKPPREKATDEGRR
Q16143 S118 GPS6|SIGNOR|iPTMNet|EPSD SNCB VAQEAAEEPLIEPLMEPEGEsYEDPPQEEyQEYEPEA____
Q16513 S952 Sugiyama PKN2 PRK2 PRKCL2 PFIPTIRGREDVSNFDDEFtsEAPILtPPREPRILsEEEQE
Q16513 T951 Sugiyama PKN2 PRK2 PRKCL2 PPFIPTIRGREDVSNFDDEFtsEAPILtPPREPRILsEEEQ
Q16513 T958 Sugiyama PKN2 PRK2 PRKCL2 RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q16576 T10 Sugiyama RBBP7 RBAP46 ___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5SSJ5 S446 Sugiyama HP1BP3 KEPDDSRDEDEDEDEssEEDsEDEEPPPKRRLQKKTPAKSP
Q5T035 T62 Sugiyama FAM120A2P C9orf129 yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q6P996 S779 Sugiyama PDXDC1 KIAA0251 QHtDQtEAFQKGVPHPEDDHsQVEGPEsLR___________
Q6PEY2 S54 Sugiyama TUBA3E GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6PKG0 T769 Sugiyama LARP1 KIAA0731 LARP ALANKLFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtP
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 S54 Sugiyama TUBA1A TUBA3 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7Z3K3 S28 Sugiyama POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003 MECEEEELEPWQKISDVIEDsVVEDyNsVDKTTTVSVSQQP
Q86UE4 S457 Sugiyama MTDH AEG1 LYRIC LPTGKSKKKKKKKKKQGEDNstAQDtEELEKEIREDLPVNt
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86XZ4 S166 Sugiyama SPATS2 SCR59 SPATA10 Nbla00526 sLSEGLETLSIDARELEDPEsAMLDTLDRTGSMLQNGVSDF
Q8NE71 S595 Sugiyama ABCF1 ABC50 TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NEN9 S496 Sugiyama PDZD8 PDZK8 SGYEEEAAGLTVDTESRELDsEFEDLAsDVRAQNEFKDEAQ
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TDU6 S310 PSP GPBAR1 TGR5 PWRAAAQRCLQGLWGRASRDsPGPSIAYHPSsQssVDLDLN
Q8TDU6 S321 PSP GPBAR1 TGR5 GLWGRASRDsPGPSIAYHPSsQssVDLDLN___________
Q8TDU6 S323 PSP GPBAR1 TGR5 WGRASRDsPGPSIAYHPSsQssVDLDLN_____________
Q8TDU6 S324 PSP GPBAR1 TGR5 GRASRDsPGPSIAYHPSsQssVDLDLN______________
Q8WVC0 S66 Sugiyama LEO1 RDL DQDERGDSGQPSNKELFGDDsEDEGAsHHsGSDNHSERSDN
Q8WX92 S542 Sugiyama NELFB COBRA1 KIAA1182 ALQKALEPTGQSGEAVKELysQLGEKLEQLDHRKPsPAQAA
Q92598 S510 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 FTISTASMVEKVPtEENEMssEADMECLNQRPPENPDTDKN
Q92769 S424 Sugiyama HDAC2 KRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGAKK
Q92973 S339 Sugiyama TNPO1 KPNB2 MIP1 TRN SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE
Q96EV2 S41 Sugiyama RBM33 PRR8 FDKPGAERSWRRRAADEDWDsELEDDLLGEDLLsGKKNQSD
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q99575 T761 Sugiyama POP1 KIAA0061 SEVPCAPMPKKTHQPSDEVGtsIEHPREAEEVMDAGCQESA
Q99613 S154 Sugiyama EIF3C EIF3S8 NAKALSTLRQKIRKyNRDFEsHItSyKQNPEQsADEDAEKN
Q99613 S39 Sugiyama EIF3C EIF3S8 GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99733 S125 Sugiyama NAP1L4 NAP2 KRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKVVVTE
Q9BQ52 S215 Sugiyama ELAC2 HPC2 QPWQsPERPLsRLsPERssDsEsNENEPHLPHGVsQRRGVR
Q9BQE3 S54 Sugiyama TUBA1C TUBA6 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BVS4 S380 Sugiyama RIOK2 RIO2 EEsEGCYCRssGDPEQIKEDsLsEEsADARsFEMTEFNQAL
Q9BVS4 S412 Sugiyama RIOK2 RIO2 EMTEFNQALEEIKGQVVENNsVTEFsEEKNRTENYNRQDGQ
Q9BW91 S343 Sugiyama NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771 SHSQFIKLVAEKRDAHWSEDsEADCHAL_____________
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZI7 S166 Sugiyama UPF3B RENT3B UPF3X KRDTKVGtIDDDPEyRKFLEsyAtDNEKMTstPEtLLEEIE
Q9H1E3 S113 Sugiyama NUCKS1 NUCKS JC7 RQAASKAASKQREMLMEDVGsEEEQEEEDEAPFQEKDsGsD
Q9H1E3 S144 Sugiyama NUCKS1 NUCKS JC7 PFQEKDsGsDEDFLMEDDDDsDyGSsKKKNKKMVKKSKPER
Q9HCN4 S338 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 HPsDLILtRGTLDEEDEEADsDtDDIDHRVTEESHEEPAFQ
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NRF8 S574 Sugiyama CTPS2 YLQQGCKLsssDRysDAsDDsFSEPRIAELEIS________
Q9NXG2 S88 Sugiyama THUMPD1 YGDDMYGPEKFtDKDQQPsGsEGEDDDAEAALKKEVGDIKA
Q9NYL9 S25 Sugiyama TMOD3 FRKDLEKyKDLDEDELLGNLsEtELKQLETVLDDLDPENAL
Q9NZB2 T413 Sugiyama FAM120A C9orf10 KIAA0183 OSSA yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q9UBN7 S22 PSP HDAC6 KIAA0901 JM21 TSTGQDSTTTRQRRsRQNPQsPPQDSSVTSKRNIKKGAVPR
Q9UG63 T35 Sugiyama ABCF2 HUSSY-18 EAAKARQRPRKGHEENGDVVtEPQVAEKNEANGRETTEVDL
Q9UGV2 S335 Sugiyama NDRG3 YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt
Q9UHD8 S482 Sugiyama SEPTIN9 KIAA0991 MSF SEPT9 TADLLSNGIDVYPQKEFDEDsEDRLVNEKFREMIPFAVVGS
Q9UPR3 S475 Sugiyama SMG5 EST1B KIAA1089 RLSCLRRRRHPPKVGDDSDLsEGFEsDSSHDSARASEGSDS
Q9UPR3 S480 Sugiyama SMG5 EST1B KIAA1089 RRRRHPPKVGDDSDLsEGFEsDSSHDSARASEGSDSGSDKS
Q9UPT8 S143 Sugiyama ZC3H4 C19orf7 KIAA1064 KSKHKRHAsSSDDFsDFsDDsDFsPSEKGHRKyREysPPyA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ80 T386 Sugiyama PA2G4 EBP1 tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9UQ88 S265 Sugiyama CDK11A CDC2L2 CDC2L3 PITSLREB APAQKPAQLKEEKMEERDLLsDLQDIsDsERKTSSAESSSA
Q9Y265 S434 Sugiyama RUVBL1 INO80H NMP238 TIP49 TIP49A NLLAKINGKDSIEKEHVEEIsELFyDAKSSAKILADQQDKY
Q9Y2B0 T79 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y3B9 S67 Sugiyama RRP15 KIAA0507 CGI-115 GSCGsEKDHFYsDDDAIEADsEGDAEPCDKENENDGEssVG
Q9Y3F4 S254 Sugiyama STRAP MAWD UNRIP EKEFLVAGGEDFKLyKyDyNsGEELEsyKGHFGPIHCVRFS
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.416967e-11 10.849 0 0
M Phase R-HSA-68886 2.066236e-11 10.685 0 0
Cell Cycle, Mitotic R-HSA-69278 5.985074e-10 9.223 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.279788e-10 9.082 0 0
Mitotic Prometaphase R-HSA-68877 1.081169e-09 8.966 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.641140e-08 7.578 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.588039e-08 7.587 0 0
Apoptotic execution phase R-HSA-75153 2.222204e-08 7.653 0 0
Chromatin organization R-HSA-4839726 2.809979e-08 7.551 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.618321e-08 7.336 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.281794e-08 7.277 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.160562e-08 7.088 0 0
Mitotic Anaphase R-HSA-68882 9.796483e-08 7.009 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.131377e-07 6.946 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.121537e-07 6.950 0 0
Chromatin modifying enzymes R-HSA-3247509 4.540710e-07 6.343 0 0
Separation of Sister Chromatids R-HSA-2467813 4.888905e-07 6.311 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.789704e-06 5.747 0 0
Recycling pathway of L1 R-HSA-437239 1.781237e-06 5.749 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.014965e-06 5.696 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.279927e-06 5.642 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.429492e-06 5.614 0 0
Mitotic Prophase R-HSA-68875 5.446769e-06 5.264 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.919527e-06 5.101 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.905112e-06 5.102 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.908771e-06 5.102 0 0
Regulation of TP53 Activity R-HSA-5633007 7.774545e-06 5.109 0 0
Aggrephagy R-HSA-9646399 9.073142e-06 5.042 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.764252e-06 5.010 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.108069e-05 4.955 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.229327e-05 4.910 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.505755e-05 4.822 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.664695e-05 4.779 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.739366e-05 4.760 0 0
L1CAM interactions R-HSA-373760 1.739478e-05 4.760 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.903763e-05 4.720 0 0
Selective autophagy R-HSA-9663891 2.117660e-05 4.674 0 0
Apoptosis R-HSA-109581 2.185108e-05 4.661 0 0
Nuclear import of Rev protein R-HSA-180746 2.231927e-05 4.651 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.594319e-05 4.586 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.594319e-05 4.586 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.567828e-05 4.590 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.964241e-05 4.528 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.215366e-05 4.493 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.117518e-05 4.385 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.665379e-05 4.331 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.091092e-05 4.293 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.205272e-05 4.284 0 0
Signal Transduction R-HSA-162582 5.893492e-05 4.230 1 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.163348e-05 4.210 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.589091e-05 4.181 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.035752e-05 4.095 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.461201e-05 4.073 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.078396e-04 3.967 0 0
Post NMDA receptor activation events R-HSA-438064 1.168017e-04 3.933 0 0
Macroautophagy R-HSA-1632852 1.412839e-04 3.850 0 0
Membrane Trafficking R-HSA-199991 1.498777e-04 3.824 0 0
mRNA Splicing R-HSA-72172 1.580505e-04 3.801 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.714891e-04 3.766 0 0
Metabolism of RNA R-HSA-8953854 1.801767e-04 3.744 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.100709e-04 3.678 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.100709e-04 3.678 0 0
Autophagy R-HSA-9612973 2.033535e-04 3.692 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.121578e-04 3.673 0 0
HIV Life Cycle R-HSA-162587 2.264467e-04 3.645 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.324704e-04 3.634 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.492130e-04 3.603 0 0
Cell Cycle Checkpoints R-HSA-69620 2.794768e-04 3.554 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.848715e-04 3.545 0 0
Gap junction trafficking and regulation R-HSA-157858 3.085286e-04 3.511 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.375949e-04 3.472 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.633546e-04 3.440 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.014168e-04 3.396 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.231608e-04 3.373 0 0
Gene expression (Transcription) R-HSA-74160 4.222092e-04 3.374 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.231608e-04 3.373 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.334537e-04 3.363 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.892927e-04 3.310 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.266376e-04 3.278 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.266376e-04 3.278 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.539451e-04 3.257 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.654172e-04 3.248 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.757329e-04 3.240 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.077934e-04 3.216 0 0
EPH-Ephrin signaling R-HSA-2682334 6.544030e-04 3.184 0 0
Metabolism of non-coding RNA R-HSA-194441 6.961023e-04 3.157 0 0
snRNP Assembly R-HSA-191859 6.961023e-04 3.157 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.348393e-04 3.134 0 0
Cellular response to heat stress R-HSA-3371556 7.997689e-04 3.097 0 0
Kinesins R-HSA-983189 8.210825e-04 3.086 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.765642e-04 3.057 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.765642e-04 3.057 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.366137e-04 3.077 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.310360e-04 3.080 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.206183e-04 3.036 0 0
Gap junction trafficking R-HSA-190828 9.399702e-04 3.027 0 0
Signaling by Hippo R-HSA-2028269 9.592907e-04 3.018 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.006510e-03 2.997 0 0
Programmed Cell Death R-HSA-5357801 1.058734e-03 2.975 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.299115e-03 2.886 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.490876e-03 2.827 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.510695e-03 2.821 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.510695e-03 2.821 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.613285e-03 2.792 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.656494e-03 2.781 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.729776e-03 2.762 0 0
MTOR signalling R-HSA-165159 1.790226e-03 2.747 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.959037e-03 2.708 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.146178e-03 2.668 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.221810e-03 2.653 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.267974e-03 2.644 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.309643e-03 2.636 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.329856e-03 2.633 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.344869e-03 2.630 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.358003e-03 2.627 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.539475e-03 2.595 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.497412e-03 2.603 0 0
Gap junction assembly R-HSA-190861 2.587393e-03 2.587 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.596382e-03 2.586 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.658030e-03 2.575 0 0
Signaling by VEGF R-HSA-194138 2.659162e-03 2.575 0 0
tRNA processing in the nucleus R-HSA-6784531 2.722770e-03 2.565 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.004714e-03 2.522 0 0
Centrosome maturation R-HSA-380287 3.024049e-03 2.519 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.405376e-03 2.468 0 0
Signaling by RAS mutants R-HSA-6802949 3.529596e-03 2.452 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.529596e-03 2.452 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.529596e-03 2.452 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.529596e-03 2.452 0 0
HIV Infection R-HSA-162906 3.287401e-03 2.483 0 0
Cell-Cell communication R-HSA-1500931 3.549177e-03 2.450 0 0
HCMV Early Events R-HSA-9609690 4.314051e-03 2.365 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.355004e-03 2.361 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.382836e-03 2.358 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.631787e-03 2.334 0 0
Signaling by ALK in cancer R-HSA-9700206 4.631787e-03 2.334 0 0
Ephrin signaling R-HSA-3928664 4.757858e-03 2.323 0 0
Signaling by ERBB2 R-HSA-1227986 4.782626e-03 2.320 0 0
Integrin signaling R-HSA-354192 4.997582e-03 2.301 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.997582e-03 2.301 0 0
Axon guidance R-HSA-422475 5.347977e-03 2.272 0 0
Nervous system development R-HSA-9675108 4.874029e-03 2.312 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.870344e-03 2.231 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.870344e-03 2.231 0 0
G2/M Transition R-HSA-69275 5.887847e-03 2.230 0 0
DCC mediated attractive signaling R-HSA-418885 5.952939e-03 2.225 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.952939e-03 2.225 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.952939e-03 2.225 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.952939e-03 2.225 0 0
Signaling by EGFR R-HSA-177929 6.373594e-03 2.196 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.642653e-03 2.178 0 0
Regulation of CDH1 Function R-HSA-9764561 7.280529e-03 2.138 0 0
Activation of BH3-only proteins R-HSA-114452 7.993255e-03 2.097 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 8.201515e-03 2.086 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.622126e-03 2.064 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.479943e-03 2.023 0 0
HDMs demethylate histones R-HSA-3214842 8.834375e-03 2.054 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.375669e-03 2.028 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.657824e-03 2.015 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.001348e-02 1.999 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.047695e-02 1.980 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.047695e-02 1.980 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.047695e-02 1.980 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.047695e-02 1.980 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.256024e-02 1.901 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.131850e-02 1.946 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.157969e-02 1.936 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.137607e-02 1.944 0 0
PKR-mediated signaling R-HSA-9833482 1.131027e-02 1.947 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.126779e-02 1.948 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.157969e-02 1.936 0 0
Cell junction organization R-HSA-446728 1.225205e-02 1.912 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.236624e-02 1.908 0 0
Cilium Assembly R-HSA-5617833 1.267788e-02 1.897 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.275844e-02 1.894 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.275881e-02 1.894 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.275881e-02 1.894 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.281311e-02 1.892 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.283871e-02 1.891 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.283871e-02 1.891 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.283871e-02 1.891 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.332961e-02 1.875 0 0
HATs acetylate histones R-HSA-3214847 1.345092e-02 1.871 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.347065e-02 1.871 0 0
Inositol phosphate metabolism R-HSA-1483249 1.366772e-02 1.864 0 0
mTORC1-mediated signalling R-HSA-166208 1.430760e-02 1.844 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.453746e-02 1.838 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.555613e-02 1.808 0 0
Striated Muscle Contraction R-HSA-390522 1.559739e-02 1.807 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.562578e-02 1.806 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.596015e-02 1.797 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.596015e-02 1.797 0 0
Regulation of CDH11 function R-HSA-9762292 1.596015e-02 1.797 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.798988e-02 1.745 0 0
MAPK family signaling cascades R-HSA-5683057 1.780509e-02 1.749 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.596015e-02 1.797 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.798988e-02 1.745 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.759449e-02 1.755 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.738175e-02 1.760 0 0
Deubiquitination R-HSA-5688426 1.813220e-02 1.742 0 0
mRNA 3'-end processing R-HSA-72187 1.884660e-02 1.725 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.884660e-02 1.725 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.887789e-02 1.724 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.948556e-02 1.710 0 0
Death Receptor Signaling R-HSA-73887 2.000228e-02 1.699 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.041606e-02 1.690 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.059242e-02 1.686 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.108332e-02 1.676 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.108332e-02 1.676 0 0
PECAM1 interactions R-HSA-210990 2.115917e-02 1.675 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.118867e-02 1.674 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.126327e-02 1.672 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.126327e-02 1.672 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.126327e-02 1.672 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.126327e-02 1.672 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.126327e-02 1.672 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.126327e-02 1.672 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.148476e-02 1.668 0 0
MHC class II antigen presentation R-HSA-2132295 2.182521e-02 1.661 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.230437e-02 1.652 0 0
Formation of definitive endoderm R-HSA-9823730 2.328209e-02 1.633 0 0
MAP2K and MAPK activation R-HSA-5674135 2.333049e-02 1.632 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.642235e-02 1.578 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.642235e-02 1.578 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.576317e-02 1.589 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.563807e-02 1.591 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.372856e-02 1.625 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.514781e-02 1.599 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.440651e-02 1.612 0 0
Glycolysis R-HSA-70171 2.646119e-02 1.577 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.769722e-02 1.558 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.771752e-02 1.557 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.771752e-02 1.557 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.845799e-02 1.546 0 0
Regulation of gap junction activity R-HSA-191650 3.008940e-02 1.522 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.008940e-02 1.522 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.008940e-02 1.522 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.263186e-02 1.486 0 0
Nuclear RNA decay R-HSA-9930044 3.263186e-02 1.486 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.263186e-02 1.486 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.263186e-02 1.486 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.296684e-02 1.482 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.319455e-02 1.479 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.319455e-02 1.479 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.335209e-02 1.477 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.361563e-02 1.473 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.426010e-02 1.465 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.458909e-02 1.461 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.458909e-02 1.461 0 0
Type I hemidesmosome assembly R-HSA-446107 3.553847e-02 1.449 0 0
Formation of annular gap junctions R-HSA-196025 3.553847e-02 1.449 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.556940e-02 1.449 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.766242e-02 1.424 0 0
DAG and IP3 signaling R-HSA-1489509 3.766242e-02 1.424 0 0
Host Interactions of HIV factors R-HSA-162909 3.895282e-02 1.409 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.953730e-02 1.403 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.410981e-02 1.355 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.410981e-02 1.355 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.625740e-02 1.335 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.625740e-02 1.335 0 0
Gap junction degradation R-HSA-190873 4.625740e-02 1.335 0 0
ALK mutants bind TKIs R-HSA-9700645 4.625740e-02 1.335 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.434410e-02 1.353 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.675115e-02 1.330 0 0
PTEN Regulation R-HSA-6807070 4.733933e-02 1.325 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.548915e-02 1.342 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.625740e-02 1.335 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.369717e-02 1.360 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.451125e-02 1.352 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.558074e-02 1.341 0 0
HCMV Infection R-HSA-9609646 4.416867e-02 1.355 0 0
RNA Polymerase II Transcription R-HSA-73857 4.618039e-02 1.336 0 0
Gene Silencing by RNA R-HSA-211000 4.788962e-02 1.320 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.069953e-02 1.390 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.548915e-02 1.342 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.831445e-02 1.316 0 0
Transcription of the HIV genome R-HSA-167172 4.843608e-02 1.315 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.063897e-02 1.296 0 0
Vesicle-mediated transport R-HSA-5653656 5.113068e-02 1.291 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.125351e-02 1.290 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.232840e-02 1.281 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.275145e-02 1.278 0 0
Rap1 signalling R-HSA-392517 5.369711e-02 1.270 0 0
Calmodulin induced events R-HSA-111933 5.396911e-02 1.268 0 0
CaM pathway R-HSA-111997 5.396911e-02 1.268 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.605335e-02 1.251 0 0
Ca-dependent events R-HSA-111996 5.605335e-02 1.251 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.737569e-02 1.241 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.773451e-02 1.239 0 0
TGFBR3 expression R-HSA-9839394 6.059152e-02 1.218 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.081582e-02 1.216 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.081582e-02 1.216 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.081582e-02 1.216 0 0
Cellular Senescence R-HSA-2559583 6.131208e-02 1.212 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.154259e-02 1.211 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.224056e-02 1.206 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.260259e-02 1.203 0 0
Signal transduction by L1 R-HSA-445144 6.274618e-02 1.202 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.274618e-02 1.202 0 0
Negative regulation of MET activity R-HSA-6807004 6.274618e-02 1.202 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.286007e-02 1.202 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.286007e-02 1.202 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.737486e-02 1.172 0 0
Protein folding R-HSA-391251 6.787210e-02 1.168 0 0
Homology Directed Repair R-HSA-5693538 6.831261e-02 1.165 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.896976e-02 1.161 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.910826e-02 1.160 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.910826e-02 1.160 0 0
ESR-mediated signaling R-HSA-8939211 7.031248e-02 1.153 0 0
Signaling by MET R-HSA-6806834 7.127510e-02 1.147 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.246895e-02 1.140 0 0
Regulation of TP53 Expression R-HSA-6804754 7.367363e-02 1.133 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.449633e-02 1.128 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.002166e-02 1.097 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 8.002166e-02 1.097 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 8.002166e-02 1.097 0 0
Activation of RAC1 R-HSA-428540 8.787517e-02 1.056 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.721835e-02 1.059 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.337365e-02 1.079 0 0
HIV elongation arrest and recovery R-HSA-167287 8.817740e-02 1.055 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.817740e-02 1.055 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.138814e-02 1.089 0 0
RAF activation R-HSA-5673000 9.048868e-02 1.043 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.314730e-02 1.031 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.429103e-02 1.026 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.615290e-02 1.017 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.120707e-02 1.040 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.721835e-02 1.059 0 0
G2/M Checkpoints R-HSA-69481 7.839748e-02 1.106 0 0
Signaling by FGFR in disease R-HSA-1226099 7.846614e-02 1.105 0 0
Cell-cell junction organization R-HSA-421270 8.946182e-02 1.048 0 0
Adherens junctions interactions R-HSA-418990 8.614961e-02 1.065 0 0
Heme signaling R-HSA-9707616 9.545228e-02 1.020 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.120707e-02 1.040 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.493661e-02 1.023 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.432976e-02 1.074 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.721835e-02 1.059 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.872093e-02 1.006 0 0
Intraflagellar transport R-HSA-5620924 9.911043e-02 1.004 0 0
Co-stimulation by CD28 R-HSA-389356 9.911043e-02 1.004 0 0
Glucose metabolism R-HSA-70326 9.970559e-02 1.001 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.975404e-02 1.001 0 0
Oncogene Induced Senescence R-HSA-2559585 1.001517e-01 0.999 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.001517e-01 0.999 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.009955e-01 0.996 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.009955e-01 0.996 0 0
Specification of primordial germ cells R-HSA-9827857 1.009955e-01 0.996 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.014951e-01 0.994 0 0
Regulation of PTEN localization R-HSA-8948747 1.014951e-01 0.994 0 0
SOS-mediated signalling R-HSA-112412 1.014951e-01 0.994 0 0
Repression of WNT target genes R-HSA-4641265 1.047191e-01 0.980 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.047191e-01 0.980 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.047191e-01 0.980 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.050403e-01 0.979 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.050403e-01 0.979 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.050403e-01 0.979 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.050403e-01 0.979 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.050403e-01 0.979 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.050403e-01 0.979 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.050403e-01 0.979 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.050403e-01 0.979 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.050403e-01 0.979 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.050403e-01 0.979 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.050403e-01 0.979 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.050403e-01 0.979 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.050403e-01 0.979 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.050403e-01 0.979 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.050403e-01 0.979 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.050403e-01 0.979 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.050403e-01 0.979 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.050403e-01 0.979 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.050403e-01 0.979 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.050403e-01 0.979 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.050403e-01 0.979 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.050403e-01 0.979 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.050403e-01 0.979 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.050403e-01 0.979 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.050403e-01 0.979 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.055121e-01 0.977 0 0
NRAGE signals death through JNK R-HSA-193648 1.055121e-01 0.977 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.072528e-01 0.970 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.072528e-01 0.970 0 0
MET interacts with TNS proteins R-HSA-8875513 1.072528e-01 0.970 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.094617e-01 0.961 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.099237e-01 0.959 0 0
FLT3 signaling in disease R-HSA-9682385 1.103702e-01 0.957 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.103702e-01 0.957 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.440001e-01 0.842 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.440001e-01 0.842 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.249750e-01 0.903 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.229061e-01 0.910 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.229061e-01 0.910 0 0
Formation of axial mesoderm R-HSA-9796292 1.229061e-01 0.910 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.229061e-01 0.910 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.229061e-01 0.910 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.157868e-01 0.936 0 0
GAB1 signalosome R-HSA-180292 1.157868e-01 0.936 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.315415e-01 0.881 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.204708e-01 0.919 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.482012e-01 0.829 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.482012e-01 0.829 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.482012e-01 0.829 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.482012e-01 0.829 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.482012e-01 0.829 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.473138e-01 0.832 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.465067e-01 0.834 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.249750e-01 0.903 0 0
EGFR downregulation R-HSA-182971 1.217703e-01 0.914 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.473138e-01 0.832 0 0
G-protein beta:gamma signalling R-HSA-397795 1.473138e-01 0.832 0 0
Hedgehog 'off' state R-HSA-5610787 1.187062e-01 0.926 0 0
Trafficking of AMPA receptors R-HSA-399719 1.217703e-01 0.914 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.361313e-01 0.866 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.473138e-01 0.832 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.324313e-01 0.878 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.273330e-01 0.895 0 0
Interferon Signaling R-HSA-913531 1.244738e-01 0.905 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.315415e-01 0.881 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.440001e-01 0.842 0 0
Regulation of KIT signaling R-HSA-1433559 1.423275e-01 0.847 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.260988e-01 0.899 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.281876e-01 0.892 0 0
Netrin-1 signaling R-HSA-373752 1.296597e-01 0.887 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.217703e-01 0.914 0 0
Regulation of beta-cell development R-HSA-186712 1.318112e-01 0.880 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.473138e-01 0.832 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.229061e-01 0.910 0 0
Signal regulatory protein family interactions R-HSA-391160 1.423275e-01 0.847 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.139102e-01 0.943 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.157868e-01 0.936 0 0
Sodium/Proton exchangers R-HSA-425986 1.249750e-01 0.903 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.315415e-01 0.881 0 0
Rab regulation of trafficking R-HSA-9007101 1.485180e-01 0.828 0 0
Myogenesis R-HSA-525793 1.490242e-01 0.827 0 0
Lipophagy R-HSA-9613354 1.501852e-01 0.823 0 0
Unwinding of DNA R-HSA-176974 1.501852e-01 0.823 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.501852e-01 0.823 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.501852e-01 0.823 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.501852e-01 0.823 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.506675e-01 0.822 0 0
PLC beta mediated events R-HSA-112043 1.511448e-01 0.821 0 0
Signaling by TGFBR3 R-HSA-9839373 1.516465e-01 0.819 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.524534e-01 0.817 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.537751e-01 0.813 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.565587e-01 0.805 0 0
Generation of second messenger molecules R-HSA-202433 1.565587e-01 0.805 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.609612e-01 0.793 0 0
Cellular responses to stress R-HSA-2262752 1.628558e-01 0.788 0 0
Erythropoietin activates RAS R-HSA-9027284 1.628647e-01 0.788 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.628647e-01 0.788 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.628647e-01 0.788 0 0
p75NTR signals via NF-kB R-HSA-193639 1.628647e-01 0.788 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.628647e-01 0.788 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.643416e-01 0.784 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.643416e-01 0.784 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.643416e-01 0.784 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.643416e-01 0.784 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.644299e-01 0.784 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.657008e-01 0.781 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.657008e-01 0.781 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.657008e-01 0.781 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.683663e-01 0.774 0 0
S Phase R-HSA-69242 1.684574e-01 0.774 0 0
Generic Transcription Pathway R-HSA-212436 1.704299e-01 0.768 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.707194e-01 0.768 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.751541e-01 0.757 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.751541e-01 0.757 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.768456e-01 0.752 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.768456e-01 0.752 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.768456e-01 0.752 0 0
Cellular responses to stimuli R-HSA-8953897 1.776120e-01 0.751 0 0
Ub-specific processing proteases R-HSA-5689880 1.785314e-01 0.748 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.802952e-01 0.744 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.825987e-01 0.739 0 0
HIV Transcription Initiation R-HSA-167161 1.825987e-01 0.739 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.825987e-01 0.739 0 0
IRS activation R-HSA-74713 1.828805e-01 0.738 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.828805e-01 0.738 0 0
G2 Phase R-HSA-68911 1.828805e-01 0.738 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.828805e-01 0.738 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.829188e-01 0.738 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.839696e-01 0.735 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.839696e-01 0.735 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.839696e-01 0.735 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.839696e-01 0.735 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.843919e-01 0.734 0 0
Phosphorylation of the APC/C R-HSA-176412 1.843919e-01 0.734 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.843919e-01 0.734 0 0
Degradation of CDH1 R-HSA-9766229 1.877833e-01 0.726 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.990526e-01 0.701 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.990526e-01 0.701 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.831942e-01 0.548 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.831942e-01 0.548 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 2.831942e-01 0.548 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.831942e-01 0.548 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.831942e-01 0.548 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.831942e-01 0.548 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.831942e-01 0.548 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.831942e-01 0.548 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.831942e-01 0.548 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.831942e-01 0.548 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.230410e-01 0.652 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.585010e-01 0.446 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.585010e-01 0.446 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.585010e-01 0.446 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.585010e-01 0.446 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.585010e-01 0.446 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.585010e-01 0.446 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.585010e-01 0.446 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.585010e-01 0.446 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.637841e-01 0.579 0 0
STAT5 Activation R-HSA-9645135 2.637841e-01 0.579 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.637841e-01 0.579 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.046796e-01 0.689 0 0
NF-kB is activated and signals survival R-HSA-209560 2.334206e-01 0.632 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.334206e-01 0.632 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.334206e-01 0.632 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.334206e-01 0.632 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.045447e-01 0.516 0 0
Disinhibition of SNARE formation R-HSA-114516 3.045447e-01 0.516 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.045447e-01 0.516 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.259000e-01 0.371 0 0
PLC-gamma1 signalling R-HSA-167021 4.259000e-01 0.371 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.259000e-01 0.371 0 0
Axonal growth stimulation R-HSA-209563 4.259000e-01 0.371 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.259000e-01 0.371 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.259000e-01 0.371 0 0
MET activates PTPN11 R-HSA-8865999 4.259000e-01 0.371 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.067792e-01 0.684 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.628163e-01 0.580 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.628163e-01 0.580 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.628163e-01 0.580 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.628163e-01 0.580 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.628163e-01 0.580 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.628163e-01 0.580 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.298950e-01 0.638 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.448698e-01 0.462 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.448698e-01 0.462 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.448698e-01 0.462 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.448698e-01 0.462 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.448698e-01 0.462 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 2.225135e-01 0.653 0 0
Signaling by Erythropoietin R-HSA-9006335 1.968374e-01 0.706 0 0
Deadenylation of mRNA R-HSA-429947 2.426316e-01 0.615 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.777907e-01 0.556 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.777907e-01 0.556 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.777907e-01 0.556 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.226508e-01 0.491 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.226508e-01 0.491 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.226508e-01 0.491 0 0
WNT mediated activation of DVL R-HSA-201688 3.844013e-01 0.415 0 0
Calcineurin activates NFAT R-HSA-2025928 3.844013e-01 0.415 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.862213e-01 0.313 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.862213e-01 0.313 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.862213e-01 0.313 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.862213e-01 0.313 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.862213e-01 0.313 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.862213e-01 0.313 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.862213e-01 0.313 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.862213e-01 0.313 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.862213e-01 0.313 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.862213e-01 0.313 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.632071e-01 0.580 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 3.526776e-01 0.453 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.526776e-01 0.453 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.526776e-01 0.453 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.526776e-01 0.453 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.103627e-01 0.677 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.841598e-01 0.546 0 0
MET promotes cell motility R-HSA-8875878 2.367032e-01 0.626 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.270691e-01 0.485 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.228611e-01 0.374 0 0
2-LTR circle formation R-HSA-164843 4.228611e-01 0.374 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.228611e-01 0.374 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.396342e-01 0.620 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.698190e-01 0.569 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.547619e-01 0.594 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.519326e-01 0.454 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.410778e-01 0.618 0 0
Meiotic synapsis R-HSA-1221632 2.410778e-01 0.618 0 0
Dual Incision in GG-NER R-HSA-5696400 3.055175e-01 0.515 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.055175e-01 0.515 0 0
FLT3 Signaling R-HSA-9607240 2.868223e-01 0.542 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.768017e-01 0.424 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.120726e-01 0.385 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.120726e-01 0.385 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.600381e-01 0.337 0 0
Signaling by APC mutants R-HSA-4839744 4.600381e-01 0.337 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.600381e-01 0.337 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.600381e-01 0.337 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.600381e-01 0.337 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.402078e-01 0.267 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 5.402078e-01 0.267 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.402078e-01 0.267 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.402078e-01 0.267 0 0
HSF1 activation R-HSA-3371511 3.440230e-01 0.463 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.701913e-01 0.432 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 4.411499e-01 0.355 0 0
HSF1-dependent transactivation R-HSA-3371571 3.340657e-01 0.476 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.261697e-01 0.370 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.957774e-01 0.305 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.957774e-01 0.305 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.957774e-01 0.305 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.957774e-01 0.305 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.442504e-01 0.463 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.135223e-01 0.384 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.668991e-01 0.435 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.696517e-01 0.328 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.696517e-01 0.328 0 0
PKA activation R-HSA-163615 4.696517e-01 0.328 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.661271e-01 0.436 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.165524e-01 0.380 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.299708e-01 0.276 0 0
Leading Strand Synthesis R-HSA-69109 5.299708e-01 0.276 0 0
Polymerase switching R-HSA-69091 5.299708e-01 0.276 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.299708e-01 0.276 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.459172e-01 0.351 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.495771e-01 0.347 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.635678e-01 0.334 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.245488e-01 0.280 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.245488e-01 0.280 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.982949e-01 0.303 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.211614e-01 0.283 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.211614e-01 0.283 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.625485e-01 0.250 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.984446e-01 0.302 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.507943e-01 0.259 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.156134e-01 0.288 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.156134e-01 0.288 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.437504e-01 0.265 0 0
Late endosomal microautophagy R-HSA-9615710 5.437504e-01 0.265 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.353538e-01 0.271 0 0
Nucleosome assembly R-HSA-774815 5.353538e-01 0.271 0 0
Translation initiation complex formation R-HSA-72649 5.325674e-01 0.274 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.492826e-01 0.260 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.533908e-01 0.257 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.533908e-01 0.257 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.657370e-01 0.247 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.657370e-01 0.247 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.672464e-01 0.435 0 0
Signaling by NOTCH1 R-HSA-1980143 4.550134e-01 0.342 0 0
Nucleotide Excision Repair R-HSA-5696398 2.343162e-01 0.630 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.963506e-01 0.707 0 0
Downstream signal transduction R-HSA-186763 2.314843e-01 0.635 0 0
HIV Transcription Elongation R-HSA-167169 4.218916e-01 0.375 0 0
DNA Damage Bypass R-HSA-73893 4.459172e-01 0.351 0 0
Lagging Strand Synthesis R-HSA-69186 5.507943e-01 0.259 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.744785e-01 0.324 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.810868e-01 0.318 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.048553e-01 0.516 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.965124e-01 0.707 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.218916e-01 0.375 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.774726e-01 0.321 0 0
PCP/CE pathway R-HSA-4086400 4.840355e-01 0.315 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.334206e-01 0.632 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.067792e-01 0.684 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.672464e-01 0.435 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.353538e-01 0.271 0 0
Developmental Cell Lineages R-HSA-9734767 4.110518e-01 0.386 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.139179e-01 0.670 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.228611e-01 0.374 0 0
Integration of provirus R-HSA-162592 4.957774e-01 0.305 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.507943e-01 0.259 0 0
Nephrin family interactions R-HSA-373753 3.023174e-01 0.520 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.841598e-01 0.546 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.844013e-01 0.415 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.415094e-01 0.617 0 0
G-protein mediated events R-HSA-112040 2.169949e-01 0.664 0 0
Meiosis R-HSA-1500620 2.392615e-01 0.621 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.045447e-01 0.516 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.045447e-01 0.516 0 0
DNA strand elongation R-HSA-69190 2.494827e-01 0.603 0 0
PI3K/AKT activation R-HSA-198203 4.228611e-01 0.374 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.024414e-01 0.395 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.218916e-01 0.375 0 0
Mitophagy R-HSA-5205647 3.055175e-01 0.515 0 0
IRS-mediated signalling R-HSA-112399 2.988917e-01 0.524 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.135134e-01 0.289 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.135134e-01 0.289 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.440230e-01 0.463 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.659828e-01 0.332 0 0
RNA Polymerase III Transcription R-HSA-74158 3.440230e-01 0.463 0 0
Adipogenesis R-HSA-9843745 4.652076e-01 0.332 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.334206e-01 0.632 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.862213e-01 0.313 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.632071e-01 0.580 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.485002e-01 0.458 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.402078e-01 0.267 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.402078e-01 0.267 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.299708e-01 0.276 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.211614e-01 0.283 0 0
Signaling by PDGF R-HSA-186797 5.144705e-01 0.289 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.768017e-01 0.424 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.334206e-01 0.632 0 0
Regulation of signaling by CBL R-HSA-912631 2.777907e-01 0.556 0 0
Long-term potentiation R-HSA-9620244 2.632071e-01 0.580 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.054108e-01 0.515 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.299708e-01 0.276 0 0
Opioid Signalling R-HSA-111885 5.108014e-01 0.292 0 0
Cyclin D associated events in G1 R-HSA-69231 5.170145e-01 0.286 0 0
G1 Phase R-HSA-69236 5.170145e-01 0.286 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.645286e-01 0.578 0 0
Signaling by WNT in cancer R-HSA-4791275 4.135223e-01 0.384 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.426784e-01 0.465 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.963082e-01 0.402 0 0
Signaling by WNT R-HSA-195721 4.083342e-01 0.389 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.298950e-01 0.638 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.777907e-01 0.556 0 0
Formation of the posterior neural plate R-HSA-9832991 4.600381e-01 0.337 0 0
PTK6 Down-Regulation R-HSA-8849472 5.402078e-01 0.267 0 0
Activation of AKT2 R-HSA-165158 5.402078e-01 0.267 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.215140e-01 0.493 0 0
PI3K Cascade R-HSA-109704 3.178231e-01 0.498 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.957774e-01 0.305 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.957774e-01 0.305 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.696517e-01 0.328 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.299708e-01 0.276 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.522902e-01 0.258 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.898602e-01 0.722 0 0
IGF1R signaling cascade R-HSA-2428924 2.818627e-01 0.550 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.861896e-01 0.313 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.679381e-01 0.330 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.251734e-01 0.371 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.861896e-01 0.313 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.844013e-01 0.415 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.984446e-01 0.302 0 0
Frs2-mediated activation R-HSA-170968 5.625485e-01 0.250 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.773487e-01 0.321 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.448698e-01 0.462 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.844013e-01 0.415 0 0
HDACs deacetylate histones R-HSA-3214815 3.999880e-01 0.398 0 0
DNA Repair R-HSA-73894 2.008101e-01 0.697 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.212590e-01 0.655 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.565242e-01 0.341 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.285250e-01 0.483 0 0
Signaling by SCF-KIT R-HSA-1433557 2.103627e-01 0.677 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.593931e-01 0.338 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.007046e-01 0.397 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.924981e-01 0.406 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.957317e-01 0.529 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.744785e-01 0.324 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.783582e-01 0.555 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.448698e-01 0.462 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.528162e-01 0.344 0 0
Semaphorin interactions R-HSA-373755 3.905430e-01 0.408 0 0
Insulin receptor signalling cascade R-HSA-74751 4.060624e-01 0.391 0 0
TCR signaling R-HSA-202403 2.853460e-01 0.545 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.844013e-01 0.415 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.054108e-01 0.515 0 0
TNF signaling R-HSA-75893 2.841010e-01 0.547 0 0
Signaling by Hedgehog R-HSA-5358351 4.553994e-01 0.342 0 0
G alpha (12/13) signalling events R-HSA-416482 2.522666e-01 0.598 0 0
Gastrulation R-HSA-9758941 4.877254e-01 0.312 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.964618e-01 0.402 0 0
Ca2+ pathway R-HSA-4086398 4.111150e-01 0.386 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.547307e-01 0.594 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.990526e-01 0.701 0 0
Inhibition of PKR R-HSA-169131 1.990526e-01 0.701 0 0
SDK interactions R-HSA-373756 1.990526e-01 0.701 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.831942e-01 0.548 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.230410e-01 0.652 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.585010e-01 0.446 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.585010e-01 0.446 0 0
Signalling to ERK5 R-HSA-198765 3.585010e-01 0.446 0 0
C6 deamination of adenosine R-HSA-75102 3.585010e-01 0.446 0 0
Bicarbonate transporters R-HSA-425381 2.046796e-01 0.689 0 0
Type II Na+/Pi cotransporters R-HSA-427589 4.259000e-01 0.371 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.448698e-01 0.462 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.448698e-01 0.462 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.926318e-01 0.534 0 0
Neurodegenerative Diseases R-HSA-8863678 2.426316e-01 0.615 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.426316e-01 0.615 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.206721e-01 0.656 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.206721e-01 0.656 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.228611e-01 0.374 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 3.825366e-01 0.417 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.698190e-01 0.569 0 0
Diseases of Immune System R-HSA-5260271 2.698190e-01 0.569 0 0
Reelin signalling pathway R-HSA-8866376 5.402078e-01 0.267 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.402078e-01 0.267 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.261697e-01 0.370 0 0
Signaling by AXIN mutants R-HSA-4839735 4.957774e-01 0.305 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.103485e-01 0.387 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.715500e-01 0.430 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.563701e-01 0.341 0 0
MET activates RAS signaling R-HSA-8851805 5.299708e-01 0.276 0 0
Regulation of IFNG signaling R-HSA-877312 5.299708e-01 0.276 0 0
Signaling by Insulin receptor R-HSA-74752 4.589080e-01 0.338 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.211614e-01 0.283 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.575574e-01 0.340 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.303134e-01 0.275 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.432027e-01 0.265 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.868223e-01 0.542 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.547307e-01 0.594 0 0
Neurexins and neuroligins R-HSA-6794361 4.984446e-01 0.302 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.256746e-01 0.371 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.226508e-01 0.491 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.507943e-01 0.259 0 0
Reproduction R-HSA-1474165 3.592928e-01 0.445 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.822829e-01 0.317 0 0
Developmental Biology R-HSA-1266738 2.771490e-01 0.557 0 0
The NLRP3 inflammasome R-HSA-844456 2.777907e-01 0.556 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.494827e-01 0.603 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.299708e-01 0.276 0 0
Mitochondrial biogenesis R-HSA-1592230 3.844526e-01 0.415 0 0
Adaptive Immune System R-HSA-1280218 3.443002e-01 0.463 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.226508e-01 0.491 0 0
Signal attenuation R-HSA-74749 4.228611e-01 0.374 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.211614e-01 0.283 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.519326e-01 0.454 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.696517e-01 0.328 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.245488e-01 0.280 0 0
Signaling by PTK6 R-HSA-8848021 2.681887e-01 0.572 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.681887e-01 0.572 0 0
Ion transport by P-type ATPases R-HSA-936837 5.459615e-01 0.263 0 0
RUNX2 regulates bone development R-HSA-8941326 3.440230e-01 0.463 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.230410e-01 0.652 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.045447e-01 0.516 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.862213e-01 0.313 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.402078e-01 0.267 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.299708e-01 0.276 0 0
Pervasive developmental disorders R-HSA-9005895 5.299708e-01 0.276 0 0
Disorders of Nervous System Development R-HSA-9697154 5.299708e-01 0.276 0 0
Transmission across Chemical Synapses R-HSA-112315 5.264298e-01 0.279 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.504949e-01 0.346 0 0
Smooth Muscle Contraction R-HSA-445355 2.410778e-01 0.618 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.744785e-01 0.324 0 0
Ion homeostasis R-HSA-5578775 4.165524e-01 0.380 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.818319e-01 0.418 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.657079e-01 0.576 0 0
PI Metabolism R-HSA-1483255 3.763409e-01 0.424 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.144705e-01 0.289 0 0
Muscle contraction R-HSA-397014 4.281310e-01 0.368 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.831942e-01 0.548 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.448698e-01 0.462 0 0
NADE modulates death signalling R-HSA-205025 4.862213e-01 0.313 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.862213e-01 0.313 0 0
RET signaling R-HSA-8853659 2.050450e-01 0.688 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.411499e-01 0.355 0 0
Potential therapeutics for SARS R-HSA-9679191 4.067711e-01 0.391 0 0
Signaling by TGFB family members R-HSA-9006936 2.597119e-01 0.586 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.701913e-01 0.432 0 0
Signaling by KIT in disease R-HSA-9669938 3.768017e-01 0.424 0 0
Signaling by ERBB4 R-HSA-1236394 5.577870e-01 0.254 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.174364e-01 0.663 0 0
Basigin interactions R-HSA-210991 3.270691e-01 0.485 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.411499e-01 0.355 0 0
Signaling by NOTCH4 R-HSA-9013694 4.257712e-01 0.371 0 0
Protein hydroxylation R-HSA-9629569 5.245488e-01 0.280 0 0
Signaling by NOTCH3 R-HSA-9012852 3.999880e-01 0.398 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.098463e-01 0.293 0 0
Mismatch Repair R-HSA-5358508 4.696517e-01 0.328 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.326708e-01 0.274 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.448698e-01 0.462 0 0
Interleukin-37 signaling R-HSA-9008059 3.701913e-01 0.432 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.350357e-01 0.361 0 0
Inflammasomes R-HSA-622312 5.211614e-01 0.283 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.526776e-01 0.453 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.183959e-01 0.661 0 0
Syndecan interactions R-HSA-3000170 4.015777e-01 0.396 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.795475e-01 0.319 0 0
Signaling by ALK R-HSA-201556 2.530989e-01 0.597 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.563701e-01 0.341 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.045447e-01 0.516 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.519326e-01 0.454 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.825366e-01 0.417 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.270357e-01 0.485 0 0
Interleukin-7 signaling R-HSA-1266695 2.632071e-01 0.580 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.442132e-01 0.612 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.844013e-01 0.415 0 0
Growth hormone receptor signaling R-HSA-982772 4.015777e-01 0.396 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.980537e-01 0.303 0 0
Influenza Infection R-HSA-168255 5.265523e-01 0.279 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.045447e-01 0.516 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.448698e-01 0.462 0 0
Interleukin-1 processing R-HSA-448706 3.844013e-01 0.415 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.829480e-01 0.417 0 0
Nephron development R-HSA-9831926 4.696517e-01 0.328 0 0
Interleukin-15 signaling R-HSA-8983432 5.299708e-01 0.276 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 5.245488e-01 0.280 0 0
Josephin domain DUBs R-HSA-5689877 4.228611e-01 0.374 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.625485e-01 0.250 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.744785e-01 0.324 0 0
Diseases of DNA repair R-HSA-9675135 3.924981e-01 0.406 0 0
OAS antiviral response R-HSA-8983711 5.299708e-01 0.276 0 0
SARS-CoV Infections R-HSA-9679506 4.627841e-01 0.335 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.402078e-01 0.267 0 0
SLC transporter disorders R-HSA-5619102 4.013981e-01 0.396 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.657370e-01 0.247 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.270691e-01 0.485 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.613960e-01 0.251 0 0
Signaling by Leptin R-HSA-2586552 4.228611e-01 0.374 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.625485e-01 0.250 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.299708e-01 0.276 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.657765e-01 0.247 0 0
Activation of the pre-replicative complex R-HSA-68962 5.657765e-01 0.247 0 0
DAP12 signaling R-HSA-2424491 5.657765e-01 0.247 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.710995e-01 0.243 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.710995e-01 0.243 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.721769e-01 0.242 0 0
Protein ubiquitination R-HSA-8852135 5.721769e-01 0.242 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.761621e-01 0.239 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.761621e-01 0.239 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.779641e-01 0.238 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.779641e-01 0.238 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.819344e-01 0.235 0 0
Budding and maturation of HIV virion R-HSA-162588 5.872025e-01 0.231 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.885244e-01 0.230 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.885244e-01 0.230 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.885244e-01 0.230 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.885244e-01 0.230 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.885244e-01 0.230 0 0
Signaling by MAPK mutants R-HSA-9652817 5.885244e-01 0.230 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.885244e-01 0.230 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.885244e-01 0.230 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.885244e-01 0.230 0 0
Terminal pathway of complement R-HSA-166665 5.885244e-01 0.230 0 0
Signaling by MST1 R-HSA-8852405 5.885244e-01 0.230 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.885244e-01 0.230 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.885244e-01 0.230 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.885244e-01 0.230 0 0
PDE3B signalling R-HSA-165160 5.885244e-01 0.230 0 0
PKB-mediated events R-HSA-109703 5.885244e-01 0.230 0 0
Synthesis of PS R-HSA-1483101 5.885244e-01 0.230 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.885244e-01 0.230 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.885244e-01 0.230 0 0
Relaxin receptors R-HSA-444821 5.885244e-01 0.230 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.885244e-01 0.230 0 0
Signaling by NOTCH R-HSA-157118 5.891202e-01 0.230 0 0
DNA Double Strand Break Response R-HSA-5693606 5.915558e-01 0.228 0 0
Removal of the Flap Intermediate R-HSA-69166 5.934726e-01 0.227 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.934726e-01 0.227 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.934726e-01 0.227 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.934726e-01 0.227 0 0
HDL assembly R-HSA-8963896 5.934726e-01 0.227 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.934726e-01 0.227 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.968094e-01 0.224 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.968094e-01 0.224 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.968094e-01 0.224 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.977845e-01 0.223 0 0
Dual incision in TC-NER R-HSA-6782135 5.977845e-01 0.223 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.006116e-01 0.221 0 0
FGFR2 alternative splicing R-HSA-6803529 6.006116e-01 0.221 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.006116e-01 0.221 0 0
LDL clearance R-HSA-8964038 6.006116e-01 0.221 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.006116e-01 0.221 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.006116e-01 0.221 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.006116e-01 0.221 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.062504e-01 0.217 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.133432e-01 0.212 0 0
Amino acid transport across the plasma membrane R-HSA-352230 6.133432e-01 0.212 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.141415e-01 0.212 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.141415e-01 0.212 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.209923e-01 0.207 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.227308e-01 0.206 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.227308e-01 0.206 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.227308e-01 0.206 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.227308e-01 0.206 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.227308e-01 0.206 0 0
p38MAPK events R-HSA-171007 6.227308e-01 0.206 0 0
Translesion synthesis by REV1 R-HSA-110312 6.227308e-01 0.206 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.227308e-01 0.206 0 0
Protein methylation R-HSA-8876725 6.227308e-01 0.206 0 0
Formation of the anterior neural plate R-HSA-9823739 6.227308e-01 0.206 0 0
DNA Damage Reversal R-HSA-73942 6.227308e-01 0.206 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.241134e-01 0.205 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.241134e-01 0.205 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.241134e-01 0.205 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.241134e-01 0.205 0 0
Sensory processing of sound R-HSA-9659379 6.275257e-01 0.202 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.281375e-01 0.202 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.281375e-01 0.202 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.285717e-01 0.202 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.285717e-01 0.202 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.285717e-01 0.202 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.285717e-01 0.202 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.285717e-01 0.202 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.317662e-01 0.199 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.317662e-01 0.199 0 0
Chylomicron clearance R-HSA-8964026 6.317662e-01 0.199 0 0
Signaling by LTK in cancer R-HSA-9842640 6.317662e-01 0.199 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.317662e-01 0.199 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.317662e-01 0.199 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.317662e-01 0.199 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.317662e-01 0.199 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.317662e-01 0.199 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.317662e-01 0.199 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.317662e-01 0.199 0 0
Nef and signal transduction R-HSA-164944 6.317662e-01 0.199 0 0
HDL clearance R-HSA-8964011 6.317662e-01 0.199 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.317662e-01 0.199 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.330368e-01 0.199 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.348027e-01 0.197 0 0
Chromosome Maintenance R-HSA-73886 6.357988e-01 0.197 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.407527e-01 0.193 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.434575e-01 0.191 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.441383e-01 0.191 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.463944e-01 0.190 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.463944e-01 0.190 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.466487e-01 0.189 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.466487e-01 0.189 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.476029e-01 0.189 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.486381e-01 0.188 0 0
Negative regulation of FLT3 R-HSA-9706369 6.503317e-01 0.187 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.503317e-01 0.187 0 0
Translesion synthesis by POLI R-HSA-5656121 6.503317e-01 0.187 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.503317e-01 0.187 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.503317e-01 0.187 0 0
Killing mechanisms R-HSA-9664420 6.503317e-01 0.187 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.503317e-01 0.187 0 0
Prolonged ERK activation events R-HSA-169893 6.503317e-01 0.187 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.503317e-01 0.187 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.503317e-01 0.187 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.503317e-01 0.187 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.503317e-01 0.187 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.503317e-01 0.187 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.539904e-01 0.184 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.579896e-01 0.182 0 0
HCMV Late Events R-HSA-9610379 6.581716e-01 0.182 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.594388e-01 0.181 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.621669e-01 0.179 0 0
Signaling by NTRKs R-HSA-166520 6.623561e-01 0.179 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.663803e-01 0.176 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.663803e-01 0.176 0 0
TBC/RABGAPs R-HSA-8854214 6.672002e-01 0.176 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.672002e-01 0.176 0 0
Synthesis of DNA R-HSA-69239 6.681875e-01 0.175 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.682073e-01 0.175 0 0
Tight junction interactions R-HSA-420029 6.682073e-01 0.175 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.682073e-01 0.175 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.682073e-01 0.175 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.682073e-01 0.175 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.704660e-01 0.174 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.704660e-01 0.174 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.704660e-01 0.174 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.704660e-01 0.174 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.704660e-01 0.174 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.704660e-01 0.174 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.704660e-01 0.174 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.704660e-01 0.174 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.704660e-01 0.174 0 0
Opsins R-HSA-419771 6.704660e-01 0.174 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.704660e-01 0.174 0 0
VLDL clearance R-HSA-8964046 6.704660e-01 0.174 0 0
Netrin mediated repulsion signals R-HSA-418886 6.704660e-01 0.174 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.704660e-01 0.174 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.704660e-01 0.174 0 0
Circadian clock R-HSA-9909396 6.718085e-01 0.173 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.721585e-01 0.173 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.763006e-01 0.170 0 0
Translesion synthesis by POLK R-HSA-5655862 6.763006e-01 0.170 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.763006e-01 0.170 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.763006e-01 0.170 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.763006e-01 0.170 0 0
Disorders of Developmental Biology R-HSA-9675151 6.763006e-01 0.170 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.763006e-01 0.170 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.763006e-01 0.170 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.763006e-01 0.170 0 0
RMTs methylate histone arginines R-HSA-3214858 6.834783e-01 0.165 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.842268e-01 0.165 0 0
Regulation of Apoptosis R-HSA-169911 6.844607e-01 0.165 0 0
Signalling to ERKs R-HSA-187687 6.844607e-01 0.165 0 0
PERK regulates gene expression R-HSA-381042 6.844607e-01 0.165 0 0
G1/S Transition R-HSA-69206 6.871065e-01 0.163 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.887871e-01 0.162 0 0
Metalloprotease DUBs R-HSA-5689901 6.887871e-01 0.162 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.887871e-01 0.162 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.892262e-01 0.162 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.898026e-01 0.161 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.969079e-01 0.157 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.976852e-01 0.156 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.992108e-01 0.155 0 0
Somitogenesis R-HSA-9824272 6.992108e-01 0.155 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.006754e-01 0.154 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.006754e-01 0.154 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.006754e-01 0.154 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.006754e-01 0.154 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.006754e-01 0.154 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.006754e-01 0.154 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.010482e-01 0.154 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.018396e-01 0.154 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 7.018396e-01 0.154 0 0
phospho-PLA2 pathway R-HSA-111995 7.051007e-01 0.152 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.051007e-01 0.152 0 0
MET receptor recycling R-HSA-8875656 7.051007e-01 0.152 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.051007e-01 0.152 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.051007e-01 0.152 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.051007e-01 0.152 0 0
Activation of RAS in B cells R-HSA-1169092 7.051007e-01 0.152 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.051007e-01 0.152 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.051007e-01 0.152 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.051007e-01 0.152 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.051007e-01 0.152 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.083927e-01 0.150 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.083927e-01 0.150 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.083927e-01 0.150 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.083927e-01 0.150 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.083927e-01 0.150 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.083927e-01 0.150 0 0
Co-inhibition by PD-1 R-HSA-389948 7.088161e-01 0.149 0 0
Signaling by FGFR1 R-HSA-5654736 7.126822e-01 0.147 0 0
UCH proteinases R-HSA-5689603 7.130756e-01 0.147 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.130756e-01 0.147 0 0
Interleukin-12 signaling R-HSA-9020591 7.130756e-01 0.147 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.143938e-01 0.146 0 0
Degradation of DVL R-HSA-4641258 7.185163e-01 0.144 0 0
PKA activation in glucagon signalling R-HSA-164378 7.235045e-01 0.141 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.235045e-01 0.141 0 0
Polo-like kinase mediated events R-HSA-156711 7.235045e-01 0.141 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.235045e-01 0.141 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.235045e-01 0.141 0 0
Apoptotic factor-mediated response R-HSA-111471 7.235045e-01 0.141 0 0
SLC-mediated transport of amino acids R-HSA-9958863 7.250725e-01 0.140 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.255996e-01 0.139 0 0
Insulin receptor recycling R-HSA-77387 7.270350e-01 0.138 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.318865e-01 0.136 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.360970e-01 0.133 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.360970e-01 0.133 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.360970e-01 0.133 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.360970e-01 0.133 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.360970e-01 0.133 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.360970e-01 0.133 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.360970e-01 0.133 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.360970e-01 0.133 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.360970e-01 0.133 0 0
mRNA Editing R-HSA-75072 7.360970e-01 0.133 0 0
ARMS-mediated activation R-HSA-170984 7.360970e-01 0.133 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.360970e-01 0.133 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.360970e-01 0.133 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.360970e-01 0.133 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.360970e-01 0.133 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.360970e-01 0.133 0 0
RNA Polymerase I Transcription R-HSA-73864 7.365400e-01 0.133 0 0
NGF-stimulated transcription R-HSA-9031628 7.431084e-01 0.129 0 0
Metal ion SLC transporters R-HSA-425410 7.431084e-01 0.129 0 0
mRNA Capping R-HSA-72086 7.447293e-01 0.128 0 0
DARPP-32 events R-HSA-180024 7.447293e-01 0.128 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.447293e-01 0.128 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.447293e-01 0.128 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.448433e-01 0.128 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.448433e-01 0.128 0 0
Translesion Synthesis by POLH R-HSA-110320 7.448433e-01 0.128 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.448433e-01 0.128 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.448433e-01 0.128 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.448433e-01 0.128 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.448433e-01 0.128 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.477658e-01 0.126 0 0
Stabilization of p53 R-HSA-69541 7.497781e-01 0.125 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.499794e-01 0.125 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.535428e-01 0.123 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.578684e-01 0.120 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.614957e-01 0.118 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.638370e-01 0.117 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.638370e-01 0.117 0 0
Binding and entry of HIV virion R-HSA-173107 7.638370e-01 0.117 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.638370e-01 0.117 0 0
Pexophagy R-HSA-9664873 7.638370e-01 0.117 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.638370e-01 0.117 0 0
Formation of apoptosome R-HSA-111458 7.638370e-01 0.117 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.638370e-01 0.117 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.638370e-01 0.117 0 0
Viral Infection Pathways R-HSA-9824446 7.641824e-01 0.117 0 0
Attenuation phase R-HSA-3371568 7.643779e-01 0.117 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.643779e-01 0.117 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.647529e-01 0.116 0 0
Signaling by NODAL R-HSA-1181150 7.647529e-01 0.116 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.667965e-01 0.115 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.667965e-01 0.115 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.667965e-01 0.115 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.696372e-01 0.114 0 0
tRNA processing R-HSA-72306 7.728727e-01 0.112 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.755108e-01 0.110 0 0
MAP kinase activation R-HSA-450294 7.758942e-01 0.110 0 0
FOXO-mediated transcription R-HSA-9614085 7.761386e-01 0.110 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.773575e-01 0.109 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.773575e-01 0.109 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.773575e-01 0.109 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.773747e-01 0.109 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.777011e-01 0.109 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.783045e-01 0.109 0 0
Toll-like Receptor Cascades R-HSA-168898 7.826194e-01 0.106 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.832980e-01 0.106 0 0
Signalling to RAS R-HSA-167044 7.832980e-01 0.106 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.832980e-01 0.106 0 0
ERK/MAPK targets R-HSA-198753 7.832980e-01 0.106 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.832980e-01 0.106 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.832980e-01 0.106 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.832980e-01 0.106 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.842337e-01 0.106 0 0
IRE1alpha activates chaperones R-HSA-381070 7.868306e-01 0.104 0 0
ChREBP activates metabolic gene expression R-HSA-163765 7.886626e-01 0.103 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.886626e-01 0.103 0 0
vRNA Synthesis R-HSA-192814 7.886626e-01 0.103 0 0
vRNP Assembly R-HSA-192905 7.886626e-01 0.103 0 0
Synthesis of PI R-HSA-1483226 7.886626e-01 0.103 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.886626e-01 0.103 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.886626e-01 0.103 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.886626e-01 0.103 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.886626e-01 0.103 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.886626e-01 0.103 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.892934e-01 0.103 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.915711e-01 0.102 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.915711e-01 0.102 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.915711e-01 0.102 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.915711e-01 0.102 0 0
G0 and Early G1 R-HSA-1538133 7.923408e-01 0.101 0 0
Orc1 removal from chromatin R-HSA-68949 7.940253e-01 0.100 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.940253e-01 0.100 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.940253e-01 0.100 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.005452e-01 0.097 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.048541e-01 0.094 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.054375e-01 0.094 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.064741e-01 0.093 0 0
Cardiogenesis R-HSA-9733709 8.064741e-01 0.093 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.084678e-01 0.092 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.108798e-01 0.091 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.108798e-01 0.091 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.108798e-01 0.091 0 0
ERKs are inactivated R-HSA-202670 8.108798e-01 0.091 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.108798e-01 0.091 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.108798e-01 0.091 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.108798e-01 0.091 0 0
Sodium/Calcium exchangers R-HSA-425561 8.108798e-01 0.091 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.108798e-01 0.091 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.108798e-01 0.091 0 0
Signaling by FGFR4 R-HSA-5654743 8.161864e-01 0.088 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.165626e-01 0.088 0 0
Notch-HLH transcription pathway R-HSA-350054 8.165626e-01 0.088 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.165626e-01 0.088 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.165626e-01 0.088 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.166903e-01 0.088 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.169503e-01 0.088 0 0
Cellular response to hypoxia R-HSA-1234174 8.184658e-01 0.087 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.192774e-01 0.087 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.197875e-01 0.086 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.217116e-01 0.085 0 0
Neuronal System R-HSA-112316 8.239223e-01 0.084 0 0
DAP12 interactions R-HSA-2172127 8.275694e-01 0.082 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.285543e-01 0.082 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.305558e-01 0.081 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.307625e-01 0.081 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.307625e-01 0.081 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.307625e-01 0.081 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.307625e-01 0.081 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.307625e-01 0.081 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.307625e-01 0.081 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.307625e-01 0.081 0 0
Signaling by LTK R-HSA-9842663 8.307625e-01 0.081 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.307625e-01 0.081 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.307625e-01 0.081 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.307625e-01 0.081 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.307625e-01 0.081 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.307625e-01 0.081 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.307625e-01 0.081 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.314180e-01 0.080 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.314180e-01 0.080 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.323124e-01 0.080 0 0
Hyaluronan metabolism R-HSA-2142845 8.323124e-01 0.080 0 0
Signaling by NOTCH2 R-HSA-1980145 8.323124e-01 0.080 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.323124e-01 0.080 0 0
Interleukin-12 family signaling R-HSA-447115 8.337813e-01 0.079 0 0
Formation of the cornified envelope R-HSA-6809371 8.363449e-01 0.078 0 0
Signaling by FGFR3 R-HSA-5654741 8.383607e-01 0.077 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.390755e-01 0.076 0 0
Integrin cell surface interactions R-HSA-216083 8.390755e-01 0.076 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.429686e-01 0.074 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.440811e-01 0.074 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.440811e-01 0.074 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.451786e-01 0.073 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.451786e-01 0.073 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.451786e-01 0.073 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.485560e-01 0.071 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.485560e-01 0.071 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.485560e-01 0.071 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.485560e-01 0.071 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.485560e-01 0.071 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.485560e-01 0.071 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.485560e-01 0.071 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.485560e-01 0.071 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.485560e-01 0.071 0 0
Processing of SMDT1 R-HSA-8949664 8.485560e-01 0.071 0 0
Maturation of nucleoprotein R-HSA-9683610 8.485560e-01 0.071 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.485798e-01 0.071 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.485798e-01 0.071 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.494248e-01 0.071 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.494248e-01 0.071 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.494248e-01 0.071 0 0
Signaling by FGFR R-HSA-190236 8.520483e-01 0.070 0 0
Signaling by ROBO receptors R-HSA-376176 8.524058e-01 0.069 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.550871e-01 0.068 0 0
Signaling by FGFR2 R-HSA-5654738 8.550871e-01 0.068 0 0
G1/S-Specific Transcription R-HSA-69205 8.551263e-01 0.068 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.579103e-01 0.067 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.579103e-01 0.067 0 0
Hyaluronan degradation R-HSA-2160916 8.579103e-01 0.067 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.592042e-01 0.066 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.615824e-01 0.065 0 0
Interleukin-17 signaling R-HSA-448424 8.623852e-01 0.064 0 0
Extension of Telomeres R-HSA-180786 8.636788e-01 0.064 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.644796e-01 0.063 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.644796e-01 0.063 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.644796e-01 0.063 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.644796e-01 0.063 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.644796e-01 0.063 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.644796e-01 0.063 0 0
Hydrolysis of LPC R-HSA-1483115 8.644796e-01 0.063 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.644796e-01 0.063 0 0
cGMP effects R-HSA-418457 8.644796e-01 0.063 0 0
Physiological factors R-HSA-5578768 8.644796e-01 0.063 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.644796e-01 0.063 0 0
Zinc transporters R-HSA-435354 8.644796e-01 0.063 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.654809e-01 0.063 0 0
Signaling by Interleukins R-HSA-449147 8.670824e-01 0.062 0 0
GPER1 signaling R-HSA-9634597 8.673824e-01 0.062 0 0
MET activates PTK2 signaling R-HSA-8874081 8.696774e-01 0.061 0 0
Sphingolipid catabolism R-HSA-9845614 8.696774e-01 0.061 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.696774e-01 0.061 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.696774e-01 0.061 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.697808e-01 0.061 0 0
Interleukin-1 signaling R-HSA-9020702 8.719937e-01 0.059 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.720140e-01 0.059 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.751778e-01 0.058 0 0
Elastic fibre formation R-HSA-1566948 8.751778e-01 0.058 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.751778e-01 0.058 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.760072e-01 0.057 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.760072e-01 0.057 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.773059e-01 0.057 0 0
Cellular response to chemical stress R-HSA-9711123 8.779785e-01 0.057 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.787298e-01 0.056 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.787298e-01 0.056 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.787298e-01 0.056 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.787298e-01 0.056 0 0
Biotin transport and metabolism R-HSA-196780 8.787298e-01 0.056 0 0
Protein lipoylation R-HSA-9857492 8.787298e-01 0.056 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.787298e-01 0.056 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.787298e-01 0.056 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.795144e-01 0.056 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.805419e-01 0.055 0 0
Triglyceride biosynthesis R-HSA-75109 8.805419e-01 0.055 0 0
Insulin processing R-HSA-264876 8.805419e-01 0.055 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.811517e-01 0.055 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.842496e-01 0.053 0 0
Neutrophil degranulation R-HSA-6798695 8.852788e-01 0.053 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.853216e-01 0.053 0 0
Leishmania phagocytosis R-HSA-9664417 8.861452e-01 0.052 0 0
Parasite infection R-HSA-9664407 8.861452e-01 0.052 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.861452e-01 0.052 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.868260e-01 0.052 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.914823e-01 0.050 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.914823e-01 0.050 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.914823e-01 0.050 0 0
Meiotic recombination R-HSA-912446 8.918079e-01 0.050 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.927282e-01 0.049 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.927282e-01 0.049 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.927282e-01 0.049 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.937532e-01 0.049 0 0
Interleukin-1 family signaling R-HSA-446652 8.976254e-01 0.047 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.990253e-01 0.046 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.990253e-01 0.046 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.995687e-01 0.046 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.997992e-01 0.046 0 0
Platelet calcium homeostasis R-HSA-418360 8.997992e-01 0.046 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.997992e-01 0.046 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.006451e-01 0.045 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.006451e-01 0.045 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.006451e-01 0.045 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.006451e-01 0.045 0 0
Maturation of spike protein R-HSA-9694548 9.006451e-01 0.045 0 0
DNA Replication R-HSA-69306 9.019176e-01 0.045 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.028944e-01 0.044 0 0
Fibronectin matrix formation R-HSA-1566977 9.028944e-01 0.044 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.028944e-01 0.044 0 0
Synthesis of PG R-HSA-1483148 9.028944e-01 0.044 0 0
Coenzyme A biosynthesis R-HSA-196783 9.028944e-01 0.044 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.028944e-01 0.044 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.028944e-01 0.044 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.055970e-01 0.043 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.080308e-01 0.042 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.083034e-01 0.042 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.083034e-01 0.042 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.083034e-01 0.042 0 0
PPARA activates gene expression R-HSA-1989781 9.100594e-01 0.041 0 0
Telomere Maintenance R-HSA-157579 9.105781e-01 0.041 0 0
Diseases of programmed cell death R-HSA-9645723 9.118269e-01 0.040 0 0
Glycogen storage diseases R-HSA-3229121 9.131070e-01 0.039 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.131070e-01 0.039 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.131070e-01 0.039 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.131070e-01 0.039 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.131070e-01 0.039 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.161279e-01 0.038 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.161279e-01 0.038 0 0
G alpha (z) signalling events R-HSA-418597 9.181895e-01 0.037 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.213269e-01 0.036 0 0
Base Excision Repair R-HSA-73884 9.214568e-01 0.036 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.222461e-01 0.035 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.222461e-01 0.035 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.222461e-01 0.035 0 0
Platelet sensitization by LDL R-HSA-432142 9.222461e-01 0.035 0 0
Tie2 Signaling R-HSA-210993 9.222461e-01 0.035 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.222461e-01 0.035 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.233214e-01 0.035 0 0
Surfactant metabolism R-HSA-5683826 9.272937e-01 0.033 0 0
rRNA processing R-HSA-72312 9.279606e-01 0.032 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.304244e-01 0.031 0 0
Pyrimidine biosynthesis R-HSA-500753 9.304244e-01 0.031 0 0
Specification of the neural plate border R-HSA-9834899 9.304244e-01 0.031 0 0
Other interleukin signaling R-HSA-449836 9.304244e-01 0.031 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.304244e-01 0.031 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.304244e-01 0.031 0 0
Maturation of nucleoprotein R-HSA-9694631 9.304244e-01 0.031 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.327163e-01 0.030 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.328423e-01 0.030 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.328423e-01 0.030 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.328423e-01 0.030 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.328423e-01 0.030 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.335334e-01 0.030 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.341856e-01 0.030 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.359976e-01 0.029 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.359976e-01 0.029 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.359976e-01 0.029 0 0
Hedgehog 'on' state R-HSA-5632684 9.370918e-01 0.028 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.377430e-01 0.028 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.377430e-01 0.028 0 0
Glycogen synthesis R-HSA-3322077 9.377430e-01 0.028 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.377430e-01 0.028 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.377430e-01 0.028 0 0
Pregnenolone biosynthesis R-HSA-196108 9.377430e-01 0.028 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.379981e-01 0.028 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.379981e-01 0.028 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.379981e-01 0.028 0 0
Triglyceride metabolism R-HSA-8979227 9.386580e-01 0.027 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.386580e-01 0.027 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.399432e-01 0.027 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.412102e-01 0.026 0 0
eNOS activation R-HSA-203615 9.415644e-01 0.026 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.415644e-01 0.026 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.415644e-01 0.026 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.415644e-01 0.026 0 0
Signal amplification R-HSA-392518 9.415644e-01 0.026 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.415644e-01 0.026 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.429190e-01 0.026 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.429190e-01 0.026 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.429885e-01 0.025 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.442921e-01 0.025 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.442921e-01 0.025 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.442921e-01 0.025 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.442921e-01 0.025 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.455155e-01 0.024 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.466687e-01 0.024 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.466687e-01 0.024 0 0
Hemostasis R-HSA-109582 9.493712e-01 0.023 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.501526e-01 0.022 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.501526e-01 0.022 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.501526e-01 0.022 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.501526e-01 0.022 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.501526e-01 0.022 0 0
Assembly Of The HIV Virion R-HSA-175474 9.501526e-01 0.022 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.504498e-01 0.022 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.504498e-01 0.022 0 0
Ion channel transport R-HSA-983712 9.507627e-01 0.022 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.513461e-01 0.022 0 0
GPVI-mediated activation cascade R-HSA-114604 9.513461e-01 0.022 0 0
Triglyceride catabolism R-HSA-163560 9.513461e-01 0.022 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.513461e-01 0.022 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.521467e-01 0.021 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.536556e-01 0.021 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.548305e-01 0.020 0 0
Azathioprine ADME R-HSA-9748787 9.551654e-01 0.020 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.553969e-01 0.020 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.553969e-01 0.020 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.553969e-01 0.020 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.553969e-01 0.020 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.553969e-01 0.020 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.553969e-01 0.020 0 0
Degradation of AXIN R-HSA-4641257 9.556300e-01 0.020 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.556300e-01 0.020 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.570684e-01 0.019 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.572920e-01 0.019 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.587014e-01 0.018 0 0
The phototransduction cascade R-HSA-2514856 9.587014e-01 0.018 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.587014e-01 0.018 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.600897e-01 0.018 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.600897e-01 0.018 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.600897e-01 0.018 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.600897e-01 0.018 0 0
Carnitine shuttle R-HSA-200425 9.600897e-01 0.018 0 0
Downstream TCR signaling R-HSA-202424 9.625880e-01 0.017 0 0
RAS processing R-HSA-9648002 9.631392e-01 0.016 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.631392e-01 0.016 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.631392e-01 0.016 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.631392e-01 0.016 0 0
Cardiac conduction R-HSA-5576891 9.635515e-01 0.016 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.642891e-01 0.016 0 0
Complex III assembly R-HSA-9865881 9.642891e-01 0.016 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.642891e-01 0.016 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.642891e-01 0.016 0 0
Kidney development R-HSA-9830369 9.662749e-01 0.015 0 0
Glycogen metabolism R-HSA-8982491 9.664200e-01 0.015 0 0
Interleukin-2 family signaling R-HSA-451927 9.664200e-01 0.015 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.664200e-01 0.015 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.680468e-01 0.014 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.680468e-01 0.014 0 0
Formation of the nephric duct R-HSA-9830364 9.680468e-01 0.014 0 0
Laminin interactions R-HSA-3000157 9.680468e-01 0.014 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.680468e-01 0.014 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.694188e-01 0.013 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.714093e-01 0.013 0 0
TRP channels R-HSA-3295583 9.714093e-01 0.013 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.714285e-01 0.013 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.721585e-01 0.012 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.721585e-01 0.012 0 0
Intra-Golgi traffic R-HSA-6811438 9.721585e-01 0.012 0 0
RSV-host interactions R-HSA-9833110 9.725205e-01 0.012 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.744181e-01 0.011 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.744181e-01 0.011 0 0
Synthesis of PE R-HSA-1483213 9.744181e-01 0.011 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.744181e-01 0.011 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.746605e-01 0.011 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.746605e-01 0.011 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.747660e-01 0.011 0 0
Synthesis of PA R-HSA-1483166 9.749832e-01 0.011 0 0
Dectin-2 family R-HSA-5621480 9.749832e-01 0.011 0 0
Platelet degranulation R-HSA-114608 9.753937e-01 0.011 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.770183e-01 0.010 0 0
Telomere Extension By Telomerase R-HSA-171319 9.771104e-01 0.010 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.771104e-01 0.010 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.771104e-01 0.010 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.771104e-01 0.010 0 0
Pyrimidine salvage R-HSA-73614 9.771104e-01 0.010 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.771104e-01 0.010 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.788705e-01 0.009 0 0
Proteasome assembly R-HSA-9907900 9.790285e-01 0.009 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.790285e-01 0.009 0 0
DNA methylation R-HSA-5334118 9.795196e-01 0.009 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.795196e-01 0.009 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.795196e-01 0.009 0 0
Immune System R-HSA-168256 9.797997e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.798204e-01 0.009 0 0
tRNA Aminoacylation R-HSA-379724 9.806253e-01 0.008 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.809294e-01 0.008 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.809294e-01 0.008 0 0
Pyruvate metabolism R-HSA-70268 9.811982e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.816753e-01 0.008 0 0
Cargo concentration in the ER R-HSA-5694530 9.836042e-01 0.007 0 0
ABC-family proteins mediated transport R-HSA-382556 9.836208e-01 0.007 0 0
ER-Phagosome pathway R-HSA-1236974 9.838041e-01 0.007 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.838392e-01 0.007 0 0
Synthesis of PC R-HSA-1483191 9.842425e-01 0.007 0 0
Translation of Structural Proteins R-HSA-9694635 9.845936e-01 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 9.857817e-01 0.006 0 0
Leishmania infection R-HSA-9658195 9.858312e-01 0.006 0 0
Parasitic Infection Pathways R-HSA-9824443 9.858312e-01 0.006 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.868265e-01 0.006 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.868745e-01 0.006 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.869930e-01 0.006 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.869930e-01 0.006 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.880294e-01 0.005 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.882564e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.882564e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.882564e-01 0.005 0 0
Complex IV assembly R-HSA-9864848 9.892736e-01 0.005 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.894929e-01 0.005 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.894929e-01 0.005 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.894929e-01 0.005 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.894929e-01 0.005 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.894929e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.897279e-01 0.004 0 0
O-linked glycosylation of mucins R-HSA-913709 9.903359e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.905257e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.905992e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.905992e-01 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 9.911622e-01 0.004 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.911960e-01 0.004 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.914553e-01 0.004 0 0
Stimuli-sensing channels R-HSA-2672351 9.914553e-01 0.004 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.915891e-01 0.004 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.915891e-01 0.004 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.919805e-01 0.003 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.924748e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.924748e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.924748e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.924748e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.925897e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.927244e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.931889e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.932673e-01 0.003 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.932673e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.939764e-01 0.003 0 0
Interferon gamma signaling R-HSA-877300 9.940604e-01 0.003 0 0
Post-translational protein modification R-HSA-597592 9.942668e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.946108e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.950809e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.951247e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.951785e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.955414e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.955414e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.956445e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.956864e-01 0.002 0 0
Aquaporin-mediated transport R-HSA-445717 9.959596e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.960469e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.960469e-01 0.002 0 0
Activation of GABAB receptors R-HSA-991365 9.961408e-01 0.002 0 0
GABA B receptor activation R-HSA-977444 9.961408e-01 0.002 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.961408e-01 0.002 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.961408e-01 0.002 0 0
Depyrimidination R-HSA-73928 9.961408e-01 0.002 0 0
Protein localization R-HSA-9609507 9.962087e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.962162e-01 0.002 0 0
Mitochondrial protein import R-HSA-1268020 9.963392e-01 0.002 0 0
Defective pyroptosis R-HSA-9710421 9.965473e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.965999e-01 0.001 0 0
Methylation R-HSA-156581 9.969111e-01 0.001 0 0
Amine ligand-binding receptors R-HSA-375280 9.969111e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.972365e-01 0.001 0 0
Cellular response to starvation R-HSA-9711097 9.973127e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.977882e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.979033e-01 0.001 0 0
Integration of energy metabolism R-HSA-163685 9.979807e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.979814e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.980213e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.980568e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.982816e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.983467e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.985041e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.985041e-01 0.001 0 0
Peptide chain elongation R-HSA-156902 9.985587e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.985833e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.986141e-01 0.001 0 0
Keratinization R-HSA-6805567 9.987258e-01 0.001 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.987678e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.988928e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.989838e-01 0.000 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.989858e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.989987e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.990042e-01 0.000 1 1
Platelet homeostasis R-HSA-418346 9.990536e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.991766e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.991883e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.992504e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.993222e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.993311e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.993791e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.994802e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.994802e-01 0.000 0 0
Regulation of insulin secretion R-HSA-422356 9.995324e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995351e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.995351e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.995971e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996280e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.996443e-01 0.000 1 1
Innate Immune System R-HSA-168249 9.996639e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996672e-01 0.000 0 0
Disease R-HSA-1643685 9.997020e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.997039e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997237e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.997337e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997381e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997618e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997618e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997618e-01 0.000 0 0
Regulated Necrosis R-HSA-5218859 9.997869e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998295e-01 0.000 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.998392e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998475e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998475e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.998498e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998776e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998780e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998917e-01 0.000 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.998934e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999132e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999302e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999363e-01 0.000 0 0
Neddylation R-HSA-8951664 9.999372e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999375e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.999500e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999500e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999579e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.999749e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999757e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999757e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999797e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999817e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999836e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999843e-01 0.000 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.999851e-01 0.000 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.999851e-01 0.000 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.999854e-01 0.000 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.999869e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999872e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999874e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999894e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999896e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999912e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999913e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999916e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.999925e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999933e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999933e-01 0.000 0 0
Translation R-HSA-72766 9.999941e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999942e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999946e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999956e-01 0.000 1 0
Selenocysteine synthesis R-HSA-2408557 9.999962e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999969e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.999969e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999976e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999984e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999986e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999994e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999994e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999997e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999998e-01 0.000 1 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Metabolism of RNA R-HSA-8953854 1.110223e-16 15.955 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.110223e-14 13.955 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.137935e-14 13.089 0 0
Cell Cycle R-HSA-1640170 8.759660e-14 13.058 0 0
mRNA Splicing R-HSA-72172 1.939560e-13 12.712 0 0
HSF1-dependent transactivation R-HSA-3371571 2.209344e-13 12.656 0 0
Cellular response to heat stress R-HSA-3371556 2.599032e-13 12.585 0 0
Attenuation phase R-HSA-3371568 1.845191e-12 11.734 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.764811e-11 10.753 0 0
M Phase R-HSA-68886 1.894340e-11 10.723 0 0
Cell Cycle, Mitotic R-HSA-69278 1.246531e-10 9.904 0 0
HSF1 activation R-HSA-3371511 4.797227e-10 9.319 0 0
Mitotic Prometaphase R-HSA-68877 5.428091e-10 9.265 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.297352e-09 8.201 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.422992e-08 7.847 0 0
Mitotic Anaphase R-HSA-68882 4.115634e-08 7.386 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.665274e-08 7.331 0 0
Separation of Sister Chromatids R-HSA-2467813 6.376721e-08 7.195 0 0
Chromatin organization R-HSA-4839726 6.091098e-08 7.215 0 0
PKR-mediated signaling R-HSA-9833482 1.220134e-07 6.914 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.035565e-07 6.691 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.688412e-07 6.571 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.405451e-07 6.130 0 0
Chromatin modifying enzymes R-HSA-3247509 7.995818e-07 6.097 0 0
Aggrephagy R-HSA-9646399 1.302982e-06 5.885 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.256537e-06 5.647 0 0
Recycling pathway of L1 R-HSA-437239 2.564698e-06 5.591 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.739742e-06 5.562 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.524463e-06 5.453 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.043951e-06 5.297 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.413584e-06 5.267 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.005113e-06 5.155 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.611032e-06 5.119 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.679353e-06 5.062 0 0
Cell Cycle Checkpoints R-HSA-69620 8.574127e-06 5.067 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.679353e-06 5.062 0 0
Cell-Cell communication R-HSA-1500931 8.796567e-06 5.056 0 0
G2/M Checkpoints R-HSA-69481 1.189562e-05 4.925 0 0
Apoptosis R-HSA-109581 1.326772e-05 4.877 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.467742e-05 4.833 0 0
rRNA processing R-HSA-72312 1.539104e-05 4.813 0 0
G2/M Transition R-HSA-69275 1.633358e-05 4.787 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.732848e-05 4.761 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.735267e-05 4.761 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.007458e-05 4.697 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.375926e-05 4.624 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.375926e-05 4.624 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.831831e-05 4.548 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.781143e-05 4.556 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.978773e-05 4.526 0 0
Cellular responses to stress R-HSA-2262752 3.132913e-05 4.504 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.345198e-05 4.476 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.586331e-05 4.445 0 0
Cellular responses to stimuli R-HSA-8953897 4.535680e-05 4.343 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.126091e-05 4.213 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.195492e-05 4.208 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.492423e-05 4.188 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.113917e-05 4.148 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.093431e-05 4.092 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.516068e-05 4.070 0 0
Cell junction organization R-HSA-446728 9.097920e-05 4.041 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.690967e-05 4.014 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.047876e-04 3.980 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.047876e-04 3.980 0 0
Programmed Cell Death R-HSA-5357801 1.105020e-04 3.957 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.312312e-04 3.882 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.384245e-04 3.859 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.451073e-04 3.838 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.668408e-04 3.778 0 0
Protein ubiquitination R-HSA-8852135 1.665907e-04 3.778 0 0
Signaling by Hippo R-HSA-2028269 1.610775e-04 3.793 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.675901e-04 3.776 0 0
Signaling by ALK in cancer R-HSA-9700206 1.675901e-04 3.776 0 0
Selective autophagy R-HSA-9663891 1.650022e-04 3.783 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.587767e-04 3.799 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.781726e-04 3.749 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.006850e-04 3.697 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.938401e-04 3.713 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.006850e-04 3.697 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.039912e-04 3.690 0 0
HIV Life Cycle R-HSA-162587 2.052166e-04 3.688 0 0
Regulation of CDH1 Function R-HSA-9764561 2.416316e-04 3.617 0 0
Cilium Assembly R-HSA-5617833 2.353993e-04 3.628 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.397156e-04 3.620 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.502759e-04 3.602 0 0
L1CAM interactions R-HSA-373760 2.510748e-04 3.600 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.603073e-04 3.585 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.053344e-04 3.515 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.987529e-04 3.525 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.041082e-04 3.517 0 0
Nucleotide Excision Repair R-HSA-5696398 3.222275e-04 3.492 0 0
Adherens junctions interactions R-HSA-418990 3.252879e-04 3.488 0 0
PTEN Regulation R-HSA-6807070 3.311121e-04 3.480 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.404088e-04 3.468 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.439872e-04 3.463 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.770073e-04 3.424 0 0
Post NMDA receptor activation events R-HSA-438064 3.770073e-04 3.424 0 0
Activation of BH3-only proteins R-HSA-114452 3.854598e-04 3.414 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.977836e-04 3.400 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.055567e-04 3.392 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.062677e-04 3.391 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.753467e-04 3.323 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.525816e-04 3.344 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.497728e-04 3.260 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.192265e-04 3.208 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.192265e-04 3.208 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.800094e-04 3.237 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.800094e-04 3.237 0 0
Nervous system development R-HSA-9675108 5.773077e-04 3.239 0 0
Gap junction trafficking and regulation R-HSA-157858 5.866655e-04 3.232 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.835068e-04 3.165 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.970633e-04 3.157 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.049750e-04 3.152 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.425135e-04 3.129 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.255354e-04 3.083 0 0
Protein folding R-HSA-391251 7.873087e-04 3.104 0 0
Gap junction trafficking R-HSA-190828 7.731791e-04 3.112 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.160499e-04 3.088 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.255354e-04 3.083 0 0
Axon guidance R-HSA-422475 9.471646e-04 3.024 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.523937e-04 3.021 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.523937e-04 3.021 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.610864e-04 3.017 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.015280e-03 2.993 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.046561e-03 2.980 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.049243e-03 2.979 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.040133e-03 2.983 0 0
Josephin domain DUBs R-HSA-5689877 1.067111e-03 2.972 0 0
DNA Repair R-HSA-73894 1.051953e-03 2.978 0 0
Cell-cell junction organization R-HSA-421270 1.012691e-03 2.995 0 0
Apoptotic execution phase R-HSA-75153 1.081640e-03 2.966 0 0
DNA Double Strand Break Response R-HSA-5693606 1.087604e-03 2.964 0 0
Gap junction assembly R-HSA-190861 1.098471e-03 2.959 0 0
Kinesins R-HSA-983189 1.110107e-03 2.955 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.110560e-03 2.954 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.140605e-03 2.943 0 0
Regulation of TP53 Activity R-HSA-5633007 1.159140e-03 2.936 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.239628e-03 2.907 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.326455e-03 2.877 0 0
Interleukin-12 signaling R-HSA-9020591 1.350677e-03 2.869 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.379865e-03 2.860 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.493493e-03 2.826 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.527608e-03 2.816 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.527608e-03 2.816 0 0
Regulation of PTEN localization R-HSA-8948747 1.956875e-03 2.708 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.899244e-03 2.721 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.032911e-03 2.692 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.021532e-03 2.694 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.090575e-03 2.680 0 0
Hedgehog 'off' state R-HSA-5610787 2.095414e-03 2.679 0 0
HIV Infection R-HSA-162906 2.152944e-03 2.667 0 0
Interleukin-12 family signaling R-HSA-447115 2.252124e-03 2.647 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.330386e-03 2.633 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.343581e-03 2.630 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.503294e-03 2.601 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.726505e-03 2.564 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.938211e-03 2.532 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.938211e-03 2.532 0 0
Centrosome maturation R-HSA-380287 2.945231e-03 2.531 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.952604e-03 2.530 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.988914e-03 2.524 0 0
Smooth Muscle Contraction R-HSA-445355 3.072630e-03 2.512 0 0
Homology Directed Repair R-HSA-5693538 3.287219e-03 2.483 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.764976e-03 2.424 0 0
S Phase R-HSA-69242 3.373423e-03 2.472 0 0
Membrane Trafficking R-HSA-199991 3.868517e-03 2.412 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.902852e-03 2.409 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.002701e-03 2.398 0 0
Intraflagellar transport R-HSA-5620924 4.165597e-03 2.380 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.256708e-03 2.371 0 0
Semaphorin interactions R-HSA-373755 4.284943e-03 2.368 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.343250e-03 2.362 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.553169e-03 2.342 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.553169e-03 2.342 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.309163e-03 2.275 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.309163e-03 2.275 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.309163e-03 2.275 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.309163e-03 2.275 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.250749e-03 2.280 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.185377e-03 2.285 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.996599e-03 2.301 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.900066e-03 2.310 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.487340e-03 2.261 0 0
Maturation of protein E R-HSA-9683683 5.487340e-03 2.261 0 0
Maturation of protein E R-HSA-9694493 5.487340e-03 2.261 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.825552e-03 2.235 0 0
TCR signaling R-HSA-202403 5.826891e-03 2.235 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.140324e-03 2.212 0 0
Deubiquitination R-HSA-5688426 6.621961e-03 2.179 0 0
Nephrin family interactions R-HSA-373753 6.731238e-03 2.172 0 0
Macroautophagy R-HSA-1632852 6.742022e-03 2.171 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.762319e-03 2.170 0 0
p75NTR signals via NF-kB R-HSA-193639 6.762319e-03 2.170 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.880266e-03 2.162 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.887517e-03 2.162 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.421846e-03 2.129 0 0
Mitotic Prophase R-HSA-68875 7.778416e-03 2.109 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.959252e-03 2.099 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.112613e-03 2.091 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.237664e-03 2.084 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.237664e-03 2.084 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.237664e-03 2.084 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.732777e-03 2.012 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.732777e-03 2.012 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.589103e-03 2.018 0 0
Translation initiation complex formation R-HSA-72649 8.939970e-03 2.049 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.920890e-03 2.003 0 0
HDACs deacetylate histones R-HSA-3214815 1.003903e-02 1.998 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.318984e-03 2.031 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.005262e-02 1.998 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.013795e-02 1.994 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.013795e-02 1.994 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.031454e-02 1.987 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.048440e-02 1.979 0 0
NF-kB is activated and signals survival R-HSA-209560 1.048440e-02 1.979 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.048440e-02 1.979 0 0
Dual Incision in GG-NER R-HSA-5696400 1.049409e-02 1.979 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.084078e-02 1.965 0 0
Autophagy R-HSA-9612973 1.101182e-02 1.958 0 0
ESR-mediated signaling R-HSA-8939211 1.125157e-02 1.949 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.156035e-02 1.937 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.233386e-02 1.909 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.254852e-02 1.901 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.255420e-02 1.901 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.312863e-02 1.882 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.330362e-02 1.876 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.350891e-02 1.869 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.372715e-02 1.862 0 0
FLT3 signaling in disease R-HSA-9682385 1.389038e-02 1.857 0 0
Dual incision in TC-NER R-HSA-6782135 1.397069e-02 1.855 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.515379e-02 1.819 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.579027e-02 1.802 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.579027e-02 1.802 0 0
mRNA 3'-end processing R-HSA-72187 1.713183e-02 1.766 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.906075e-02 1.720 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.906130e-02 1.720 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.906130e-02 1.720 0 0
Ub-specific processing proteases R-HSA-5689880 1.882603e-02 1.725 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.879205e-02 1.726 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.601485e-02 1.795 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.711227e-02 1.767 0 0
Signaling by ERBB2 R-HSA-1227986 1.717936e-02 1.765 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.604654e-02 1.795 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.604654e-02 1.795 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.879450e-02 1.726 0 0
Signaling by Hedgehog R-HSA-5358351 1.836857e-02 1.736 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.740888e-02 1.759 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.655002e-02 1.781 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.604654e-02 1.795 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.926330e-02 1.715 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.942506e-02 1.712 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.945642e-02 1.711 0 0
Gene expression (Transcription) R-HSA-74160 1.999343e-02 1.699 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.041958e-02 1.690 0 0
Stabilization of p53 R-HSA-69541 2.041958e-02 1.690 0 0
Signaling by ROBO receptors R-HSA-376176 2.092458e-02 1.679 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.103151e-02 1.677 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.103151e-02 1.677 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.103151e-02 1.677 0 0
Signaling by RAS mutants R-HSA-6802949 2.103151e-02 1.677 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.120729e-02 1.674 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.126515e-02 1.672 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.126515e-02 1.672 0 0
Unwinding of DNA R-HSA-176974 2.126515e-02 1.672 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.186128e-02 1.660 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.285787e-02 1.641 0 0
Metalloprotease DUBs R-HSA-5689901 2.285787e-02 1.641 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.301988e-02 1.638 0 0
Generation of second messenger molecules R-HSA-202433 2.301988e-02 1.638 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.301988e-02 1.638 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.315248e-02 1.635 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.345398e-02 1.630 0 0
Striated Muscle Contraction R-HSA-390522 2.489024e-02 1.604 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.489024e-02 1.604 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.594553e-02 1.586 0 0
Translesion synthesis by REV1 R-HSA-110312 2.594553e-02 1.586 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.594553e-02 1.586 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.704699e-02 1.568 0 0
Basigin interactions R-HSA-210991 2.704699e-02 1.568 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.741261e-02 1.562 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.741261e-02 1.562 0 0
Pexophagy R-HSA-9664873 2.741261e-02 1.562 0 0
Interferon Signaling R-HSA-913531 2.741802e-02 1.562 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.302301e-02 1.481 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.302301e-02 1.481 0 0
Negative regulation of FLT3 R-HSA-9706369 3.131108e-02 1.504 0 0
Translesion synthesis by POLI R-HSA-5656121 3.131108e-02 1.504 0 0
Metabolism of non-coding RNA R-HSA-194441 3.414381e-02 1.467 0 0
snRNP Assembly R-HSA-191859 3.414381e-02 1.467 0 0
Degradation of CDH1 R-HSA-9766229 2.890014e-02 1.539 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.283761e-02 1.484 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.302301e-02 1.481 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.027767e-02 1.519 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.451633e-02 1.462 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.820077e-02 1.550 0 0
Muscle contraction R-HSA-397014 3.401655e-02 1.468 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.162069e-02 1.500 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.382428e-02 1.471 0 0
Host Interactions of HIV factors R-HSA-162909 3.478899e-02 1.459 0 0
EPH-Ephrin signaling R-HSA-2682334 3.518125e-02 1.454 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.570866e-02 1.447 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.639897e-02 1.439 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.667045e-02 1.436 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.730025e-02 1.428 0 0
Disorders of Developmental Biology R-HSA-9675151 3.732340e-02 1.428 0 0
Translesion synthesis by POLK R-HSA-5655862 3.732340e-02 1.428 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.732340e-02 1.428 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.732340e-02 1.428 0 0
Orc1 removal from chromatin R-HSA-68949 3.865869e-02 1.413 0 0
Signaling by VEGF R-HSA-194138 3.917130e-02 1.407 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.961924e-02 1.402 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.992486e-02 1.399 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.065519e-02 1.391 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.093959e-02 1.388 0 0
Influenza Infection R-HSA-168255 4.203821e-02 1.376 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.236209e-02 1.373 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.259086e-02 1.371 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.259086e-02 1.371 0 0
Glycogen storage diseases R-HSA-3229121 4.399658e-02 1.357 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.418789e-02 1.355 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.418789e-02 1.355 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.446020e-02 1.352 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.538278e-02 1.343 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.538278e-02 1.343 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.541165e-02 1.343 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.619239e-02 1.335 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.619239e-02 1.335 0 0
Regulation of TP53 Expression R-HSA-6804754 4.755224e-02 1.323 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.755224e-02 1.323 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.755224e-02 1.323 0 0
Recycling of eIF2:GDP R-HSA-72731 5.697605e-02 1.244 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.163867e-02 1.287 0 0
Disorders of Nervous System Development R-HSA-9697154 5.163867e-02 1.287 0 0
Pervasive developmental disorders R-HSA-9005895 5.163867e-02 1.287 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.163867e-02 1.287 0 0
Ephrin signaling R-HSA-3928664 5.133940e-02 1.290 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.935541e-02 1.227 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.542811e-02 1.256 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.808464e-02 1.318 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.649405e-02 1.248 0 0
Translesion Synthesis by POLH R-HSA-110320 5.935541e-02 1.227 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.004463e-02 1.222 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.165110e-02 1.210 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.451482e-02 1.263 0 0
HDMs demethylate histones R-HSA-3214842 5.479003e-02 1.261 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.273415e-02 1.278 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.163867e-02 1.287 0 0
CHL1 interactions R-HSA-447041 5.697605e-02 1.244 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.275485e-02 1.278 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.133940e-02 1.290 0 0
Cellular response to hypoxia R-HSA-1234174 5.615187e-02 1.251 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.451482e-02 1.263 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.797974e-02 1.319 0 0
Signaling by PTK6 R-HSA-8848021 4.797974e-02 1.319 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.932158e-02 1.307 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.275485e-02 1.278 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.697605e-02 1.244 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.479003e-02 1.261 0 0
Signaling by NOTCH4 R-HSA-9013694 5.672843e-02 1.246 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.163867e-02 1.287 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.163867e-02 1.287 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.542811e-02 1.256 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.932158e-02 1.307 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.163867e-02 1.287 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.163867e-02 1.287 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.163867e-02 1.287 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.089767e-02 1.215 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.165110e-02 1.210 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.165740e-02 1.210 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.288958e-02 1.201 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.288958e-02 1.201 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.288958e-02 1.201 0 0
Potential therapeutics for SARS R-HSA-9679191 6.319837e-02 1.199 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.485993e-02 1.188 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 8.275815e-02 1.082 0 0
FLT3 mutants bind TKIs R-HSA-9702509 8.275815e-02 1.082 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 8.275815e-02 1.082 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 8.275815e-02 1.082 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 8.275815e-02 1.082 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 8.275815e-02 1.082 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 8.275815e-02 1.082 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 8.275815e-02 1.082 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 8.275815e-02 1.082 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 8.275815e-02 1.082 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 8.275815e-02 1.082 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 8.275815e-02 1.082 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 8.275815e-02 1.082 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 8.275815e-02 1.082 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 8.275815e-02 1.082 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 8.275815e-02 1.082 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 8.275815e-02 1.082 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 8.275815e-02 1.082 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 9.577237e-02 1.019 0 0
ALK mutants bind TKIs R-HSA-9700645 8.708245e-02 1.060 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.448586e-02 1.073 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.724492e-02 1.012 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.724492e-02 1.012 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.739623e-02 1.111 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.740387e-02 1.058 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.740387e-02 1.058 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.740387e-02 1.058 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.940987e-02 1.159 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.940987e-02 1.159 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.940987e-02 1.159 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.940987e-02 1.159 0 0
Notch-HLH transcription pathway R-HSA-350054 9.805097e-02 1.009 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.748655e-02 1.111 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.748655e-02 1.111 0 0
HIV elongation arrest and recovery R-HSA-167287 7.748655e-02 1.111 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.748655e-02 1.111 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.607009e-02 1.065 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.607009e-02 1.065 0 0
Late endosomal microautophagy R-HSA-9615710 8.607009e-02 1.065 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.515404e-02 1.022 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.281197e-02 1.082 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.030793e-02 1.095 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.670268e-02 1.062 0 0
Meiotic synapsis R-HSA-1221632 8.670268e-02 1.062 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.514313e-02 1.124 0 0
Transcription of the HIV genome R-HSA-167172 7.005826e-02 1.155 0 0
RNA Polymerase III Transcription R-HSA-74158 8.281197e-02 1.082 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.515404e-02 1.022 0 0
Activation of the pre-replicative complex R-HSA-68962 9.515404e-02 1.022 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.805097e-02 1.009 0 0
Degradation of DVL R-HSA-4641258 9.068394e-02 1.042 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.282507e-02 1.032 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.670268e-02 1.062 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.448586e-02 1.073 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.090584e-02 1.149 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.260940e-02 1.139 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.805097e-02 1.009 0 0
Regulation of Apoptosis R-HSA-169911 7.534901e-02 1.123 0 0
Nuclear import of Rev protein R-HSA-180746 6.829730e-02 1.166 0 0
RNA Polymerase I Transcription R-HSA-73864 7.460309e-02 1.127 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.176553e-02 1.037 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.068394e-02 1.042 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.177536e-02 1.144 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.534901e-02 1.123 0 0
Ovarian tumor domain proteases R-HSA-5689896 9.068394e-02 1.042 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.481008e-02 1.023 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.740387e-02 1.058 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.260940e-02 1.139 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.940987e-02 1.159 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.829730e-02 1.166 0 0
Glycogen synthesis R-HSA-3322077 6.804313e-02 1.167 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 7.028138e-02 1.153 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 9.577237e-02 1.019 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.708245e-02 1.060 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.740387e-02 1.058 0 0
mTORC1-mediated signalling R-HSA-166208 9.805097e-02 1.009 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.739623e-02 1.111 0 0
Vesicle-mediated transport R-HSA-5653656 9.523054e-02 1.021 0 0
Ca-dependent events R-HSA-111996 7.212695e-02 1.142 0 0
Synthesis of DNA R-HSA-69239 9.802474e-02 1.009 0 0
Calmodulin induced events R-HSA-111933 8.281197e-02 1.082 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.804313e-02 1.167 0 0
Negative regulation of MET activity R-HSA-6807004 6.804313e-02 1.167 0 0
CaM pathway R-HSA-111997 8.281197e-02 1.082 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.448586e-02 1.073 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.805097e-02 1.009 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.708245e-02 1.060 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.448586e-02 1.073 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.448586e-02 1.073 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.739623e-02 1.111 0 0
Death Receptor Signaling R-HSA-73887 7.605966e-02 1.119 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.868302e-02 1.104 0 0
Oncogene Induced Senescence R-HSA-2559585 7.534901e-02 1.123 0 0
Mitophagy R-HSA-5205647 6.829730e-02 1.166 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.045544e-02 1.094 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.260940e-02 1.139 0 0
Viral Infection Pathways R-HSA-9824446 6.985922e-02 1.156 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.463937e-02 1.127 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.740387e-02 1.058 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.448586e-02 1.073 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.740387e-02 1.058 0 0
MHC class II antigen presentation R-HSA-2132295 9.162801e-02 1.038 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.364217e-02 1.133 0 0
Regulation of BACH1 activity R-HSA-9708530 9.724492e-02 1.012 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.896101e-02 1.005 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.003739e-01 0.998 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.004076e-01 0.998 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.004076e-01 0.998 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.004076e-01 0.998 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.004076e-01 0.998 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.037830e-01 0.984 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.041776e-01 0.982 0 0
2-LTR circle formation R-HSA-164843 1.041776e-01 0.982 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.041776e-01 0.982 0 0
IRE1alpha activates chaperones R-HSA-381070 1.044296e-01 0.981 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.047294e-01 0.980 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.047294e-01 0.980 0 0
EGFR downregulation R-HSA-182971 1.047294e-01 0.980 0 0
Budding and maturation of HIV virion R-HSA-162588 1.047294e-01 0.980 0 0
SARS-CoV Infections R-HSA-9679506 1.054727e-01 0.977 0 0
G1/S Transition R-HSA-69206 1.054859e-01 0.977 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.075234e-01 0.968 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.076376e-01 0.968 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.076376e-01 0.968 0 0
Signaling by ALK R-HSA-201556 1.076376e-01 0.968 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.076469e-01 0.968 0 0
Signaling by EGFR R-HSA-177929 1.076469e-01 0.968 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.076469e-01 0.968 0 0
Signal Transduction R-HSA-162582 1.081013e-01 0.966 1 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.083268e-01 0.965 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 1.093186e-01 0.961 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 1.093186e-01 0.961 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.093186e-01 0.961 0 0
Syndecan interactions R-HSA-3000170 1.093186e-01 0.961 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.102128e-01 0.958 0 0
Iron uptake and transport R-HSA-917937 1.104431e-01 0.957 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.108443e-01 0.955 0 0
Developmental Cell Lineages R-HSA-9734767 1.109450e-01 0.955 0 0
DNA strand elongation R-HSA-69190 1.147850e-01 0.940 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.147850e-01 0.940 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.152079e-01 0.939 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.167068e-01 0.933 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.167068e-01 0.933 0 0
HIV Transcription Elongation R-HSA-167169 1.167068e-01 0.933 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.167068e-01 0.933 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.167068e-01 0.933 0 0
UCH proteinases R-HSA-5689603 1.171218e-01 0.931 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.171218e-01 0.931 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.179766e-01 0.928 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.204784e-01 0.919 0 0
Bicarbonate transporters R-HSA-425381 1.224696e-01 0.912 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.234131e-01 0.909 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.234131e-01 0.909 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.234131e-01 0.909 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.234131e-01 0.909 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.234131e-01 0.909 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.234131e-01 0.909 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.240152e-01 0.907 0 0
DNA Damage Bypass R-HSA-73893 1.251563e-01 0.903 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.251563e-01 0.903 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.252361e-01 0.902 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.252361e-01 0.902 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.253073e-01 0.902 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.253073e-01 0.902 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.253073e-01 0.902 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.256702e-01 0.901 0 0
FLT3 Signaling R-HSA-9607240 1.261598e-01 0.899 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.261598e-01 0.899 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.261598e-01 0.899 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.277552e-01 0.894 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.299759e-01 0.886 0 0
TGFBR3 expression R-HSA-9839394 1.336221e-01 0.874 0 0
Long-term potentiation R-HSA-9620244 1.336221e-01 0.874 0 0
MAP2K and MAPK activation R-HSA-5674135 1.359868e-01 0.867 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.359868e-01 0.867 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.359868e-01 0.867 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.359868e-01 0.867 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.362808e-01 0.866 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.362808e-01 0.866 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.367923e-01 0.864 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.395777e-01 0.855 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.395777e-01 0.855 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.395777e-01 0.855 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.395777e-01 0.855 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.395777e-01 0.855 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.403678e-01 0.853 0 0
Apoptotic factor-mediated response R-HSA-111471 1.403678e-01 0.853 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.403678e-01 0.853 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.586719e-01 0.799 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.586719e-01 0.799 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.586719e-01 0.799 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.586719e-01 0.799 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.586719e-01 0.799 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.586719e-01 0.799 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.586719e-01 0.799 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.586719e-01 0.799 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.586719e-01 0.799 0 0
UNC93B1 deficiency - HSE R-HSA-5602415 1.586719e-01 0.799 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.586719e-01 0.799 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.283069e-01 0.641 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.283069e-01 0.641 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.283069e-01 0.641 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.283069e-01 0.641 0 0
Defective CD320 causes MMATC R-HSA-3359485 2.283069e-01 0.641 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.283069e-01 0.641 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.526738e-01 0.816 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.830975e-01 0.737 0 0
Activation of RAC1 R-HSA-428540 1.418279e-01 0.848 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.142916e-01 0.669 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 2.142916e-01 0.669 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.142916e-01 0.669 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.142916e-01 0.669 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.621202e-01 0.790 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.621202e-01 0.790 0 0
Type I hemidesmosome assembly R-HSA-446107 2.459206e-01 0.609 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.459206e-01 0.609 0 0
Formation of annular gap junctions R-HSA-196025 2.459206e-01 0.609 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.459206e-01 0.609 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.832148e-01 0.737 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.832148e-01 0.737 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.561832e-01 0.806 0 0
ARMS-mediated activation R-HSA-170984 2.776991e-01 0.556 0 0
Gap junction degradation R-HSA-190873 2.776991e-01 0.556 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.726237e-01 0.763 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.726237e-01 0.763 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.726237e-01 0.763 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.726237e-01 0.763 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.595106e-01 0.797 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.250841e-01 0.648 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.731008e-01 0.564 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.731008e-01 0.564 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.527785e-01 0.816 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.620549e-01 0.582 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.625867e-01 0.789 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.809565e-01 0.551 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.240864e-01 0.650 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.520198e-01 0.599 0 0
HIV Transcription Initiation R-HSA-167161 2.520198e-01 0.599 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.520198e-01 0.599 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.953550e-01 0.709 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.390361e-01 0.622 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.663356e-01 0.575 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.808493e-01 0.552 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.032172e-01 0.692 0 0
Peptide chain elongation R-HSA-156902 2.228973e-01 0.652 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.614307e-01 0.583 0 0
Ribosome-associated quality control R-HSA-9948299 2.710634e-01 0.567 0 0
Signaling by NOTCH2 R-HSA-1980145 1.476882e-01 0.831 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.379281e-01 0.624 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.033264e-01 0.692 0 0
RAF activation R-HSA-5673000 2.823284e-01 0.549 0 0
mRNA Capping R-HSA-72086 1.884953e-01 0.725 0 0
Integrin signaling R-HSA-354192 2.499092e-01 0.602 0 0
Integration of provirus R-HSA-162592 1.418279e-01 0.848 0 0
DCC mediated attractive signaling R-HSA-418885 2.272984e-01 0.643 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.919297e-01 0.717 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.731008e-01 0.564 0 0
Molecules associated with elastic fibres R-HSA-2129379 2.185308e-01 0.660 0 0
Nuclear RNA decay R-HSA-9930044 2.499092e-01 0.602 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.479170e-01 0.606 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.479170e-01 0.606 0 0
Eukaryotic Translation Termination R-HSA-72764 2.118152e-01 0.674 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.919297e-01 0.717 0 0
Myogenesis R-HSA-525793 1.466039e-01 0.834 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.823284e-01 0.549 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.660076e-01 0.575 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 1.526738e-01 0.816 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.499092e-01 0.602 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.518120e-01 0.599 0 0
Meiosis R-HSA-1500620 1.868797e-01 0.728 0 0
ER-Phagosome pathway R-HSA-1236974 2.323132e-01 0.634 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.105205e-01 0.677 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.157958e-01 0.666 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.586719e-01 0.799 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.832148e-01 0.737 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 2.776991e-01 0.556 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.595106e-01 0.797 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.595106e-01 0.797 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.731008e-01 0.564 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.499092e-01 0.602 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.520198e-01 0.599 0 0
PCP/CE pathway R-HSA-4086400 2.150281e-01 0.668 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.884953e-01 0.725 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.240864e-01 0.650 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.240864e-01 0.650 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.476882e-01 0.831 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.526738e-01 0.816 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.660076e-01 0.575 0 0
Adrenoceptors R-HSA-390696 2.459206e-01 0.609 0 0
Interleukin-1 signaling R-HSA-9020702 2.663864e-01 0.574 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.663594e-01 0.779 0 0
Rap1 signalling R-HSA-392517 1.561832e-01 0.806 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.567163e-01 0.805 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.698907e-01 0.770 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.776991e-01 0.556 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.776991e-01 0.556 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.561832e-01 0.806 0 0
Signal transduction by L1 R-HSA-445144 1.726237e-01 0.763 0 0
RNA Polymerase II Transcription R-HSA-73857 2.321814e-01 0.634 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.586719e-01 0.799 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.283069e-01 0.641 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.832148e-01 0.737 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 2.500423e-01 0.602 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.717273e-01 0.765 0 0
Degradation of AXIN R-HSA-4641257 1.843167e-01 0.734 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.843167e-01 0.734 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.787908e-01 0.748 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.726790e-01 0.763 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.571753e-01 0.804 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.141563e-01 0.669 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.823284e-01 0.549 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.502694e-01 0.602 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.015232e-01 0.696 0 0
MTOR signalling R-HSA-165159 1.461765e-01 0.835 0 0
DNA Replication R-HSA-69306 2.310823e-01 0.636 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.500423e-01 0.602 0 0
HATs acetylate histones R-HSA-3214847 1.630113e-01 0.788 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.379281e-01 0.624 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.865012e-01 0.729 0 0
TNF signaling R-HSA-75893 1.936706e-01 0.713 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.776991e-01 0.556 0 0
tRNA processing in the nucleus R-HSA-6784531 2.621857e-01 0.581 0 0
Cellular Senescence R-HSA-2559583 2.066185e-01 0.685 0 0
PLC beta mediated events R-HSA-112043 2.502694e-01 0.602 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.526738e-01 0.816 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.776991e-01 0.556 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.476882e-01 0.831 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.432645e-01 0.844 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.902952e-01 0.721 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.518120e-01 0.599 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.015232e-01 0.696 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.466039e-01 0.834 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.620549e-01 0.582 0 0
DAG and IP3 signaling R-HSA-1489509 1.787908e-01 0.748 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.152179e-01 0.667 0 0
Developmental Biology R-HSA-1266738 2.415715e-01 0.617 0 0
Ion homeostasis R-HSA-5578775 1.936706e-01 0.713 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.520198e-01 0.599 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.240250e-01 0.650 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.283069e-01 0.641 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.830975e-01 0.737 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.561832e-01 0.806 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.726237e-01 0.763 0 0
Protein methylation R-HSA-8876725 2.272984e-01 0.643 0 0
Downstream TCR signaling R-HSA-202424 2.418792e-01 0.616 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.499092e-01 0.602 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.116286e-01 0.674 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.972557e-01 0.705 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.459206e-01 0.609 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.434226e-01 0.843 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.776991e-01 0.556 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.600989e-01 0.796 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.499092e-01 0.602 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.823284e-01 0.549 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.787908e-01 0.748 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.787908e-01 0.748 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.600324e-01 0.796 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.294623e-01 0.639 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.814063e-01 0.551 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 1.526738e-01 0.816 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.142916e-01 0.669 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.600989e-01 0.796 0 0
Assembly Of The HIV Virion R-HSA-175474 2.071361e-01 0.684 0 0
Trafficking of AMPA receptors R-HSA-399719 2.185308e-01 0.660 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.379281e-01 0.624 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.647867e-01 0.577 0 0
Sensory processing of sound R-HSA-9659379 2.248701e-01 0.648 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.600989e-01 0.796 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.379281e-01 0.624 0 0
Nef and signal transduction R-HSA-164944 1.830975e-01 0.737 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.142916e-01 0.669 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.776991e-01 0.556 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.272984e-01 0.643 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.896286e-01 0.722 0 0
RMTs methylate histone arginines R-HSA-3214858 1.675927e-01 0.776 0 0
Signaling by ERBB4 R-HSA-1236394 1.775397e-01 0.751 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.278747e-01 0.642 0 0
Signaling by Interleukins R-HSA-449147 1.790547e-01 0.747 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.459206e-01 0.609 0 0
Regulation of signaling by CBL R-HSA-912631 1.561832e-01 0.806 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.808493e-01 0.552 0 0
FOXO-mediated transcription R-HSA-9614085 2.476700e-01 0.606 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.071361e-01 0.684 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.499092e-01 0.602 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.009514e-01 0.697 0 0
Ion transport by P-type ATPases R-HSA-936837 2.864978e-01 0.543 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.921822e-01 0.534 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.921822e-01 0.534 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.921822e-01 0.534 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.921822e-01 0.534 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.955347e-01 0.529 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.955347e-01 0.529 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.963668e-01 0.528 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.963668e-01 0.528 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.979412e-01 0.526 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.994645e-01 0.524 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.000575e-01 0.523 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.000575e-01 0.523 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.000575e-01 0.523 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.000575e-01 0.523 0 0
Signaling by NOTCH1 R-HSA-1980143 3.045861e-01 0.516 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.093859e-01 0.509 0 0
Formation of apoptosome R-HSA-111458 3.093859e-01 0.509 0 0
Regulation of CDH11 function R-HSA-9762292 3.093859e-01 0.509 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.093859e-01 0.509 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.103657e-01 0.508 0 0
Nucleosome assembly R-HSA-774815 3.103657e-01 0.508 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.103657e-01 0.508 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.103657e-01 0.508 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.103657e-01 0.508 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.103657e-01 0.508 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.150381e-01 0.502 0 0
HCMV Early Events R-HSA-9609690 3.154399e-01 0.501 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.193015e-01 0.496 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.193015e-01 0.496 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.197408e-01 0.495 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.197408e-01 0.495 0 0
GAB1 signalosome R-HSA-180292 3.197408e-01 0.495 0 0
PKA activation R-HSA-163615 3.197408e-01 0.495 0 0
PKA activation in glucagon signalling R-HSA-164378 3.197408e-01 0.495 0 0
G-protein mediated events R-HSA-112040 3.239382e-01 0.490 0 0
Signaling by TGFBR3 R-HSA-9839373 3.253167e-01 0.488 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.253167e-01 0.488 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.322553e-01 0.479 0 0
Regulated Necrosis R-HSA-5218859 3.366167e-01 0.473 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.386345e-01 0.470 0 0
Formation of the posterior neural plate R-HSA-9832991 3.407787e-01 0.468 0 0
vRNP Assembly R-HSA-192905 3.407787e-01 0.468 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 3.407787e-01 0.468 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.407787e-01 0.468 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.431303e-01 0.465 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.440245e-01 0.463 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.440245e-01 0.463 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.440245e-01 0.463 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.440245e-01 0.463 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.490995e-01 0.457 0 0
Elastic fibre formation R-HSA-1566948 3.490995e-01 0.457 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.490995e-01 0.457 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.507739e-01 0.455 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 3.507739e-01 0.455 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.507739e-01 0.455 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.507739e-01 0.455 0 0
Defective ABCA1 causes TGD R-HSA-5682113 3.507739e-01 0.455 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.507739e-01 0.455 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.507739e-01 0.455 0 0
MET interacts with TNS proteins R-HSA-8875513 3.507739e-01 0.455 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.557504e-01 0.449 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.580049e-01 0.446 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.580049e-01 0.446 0 0
DARPP-32 events R-HSA-180024 3.580049e-01 0.446 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.580049e-01 0.446 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.580049e-01 0.446 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.580049e-01 0.446 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.621806e-01 0.441 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.648846e-01 0.438 0 0
Glycolysis R-HSA-70171 3.654279e-01 0.437 0 0
ABC-family proteins mediated transport R-HSA-382556 3.654279e-01 0.437 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.656169e-01 0.437 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.656169e-01 0.437 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.659873e-01 0.437 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.664505e-01 0.436 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.664505e-01 0.436 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.664505e-01 0.436 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.717091e-01 0.430 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.717091e-01 0.430 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.717091e-01 0.430 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.717091e-01 0.430 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.773637e-01 0.423 0 0
Interleukin-37 signaling R-HSA-9008059 3.773637e-01 0.423 0 0
Glycogen metabolism R-HSA-8982491 3.828860e-01 0.417 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.828860e-01 0.417 0 0
Chromosome Maintenance R-HSA-73886 3.852195e-01 0.414 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.860091e-01 0.413 0 0
Translation R-HSA-72766 3.864337e-01 0.413 0 0
MAP kinase activation R-HSA-450294 3.873097e-01 0.412 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.879215e-01 0.411 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.896242e-01 0.409 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.896242e-01 0.409 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.966649e-01 0.402 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.966649e-01 0.402 0 0
Interleukin-1 family signaling R-HSA-446652 3.994907e-01 0.398 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.997642e-01 0.398 0 0
Repression of WNT target genes R-HSA-4641265 4.020387e-01 0.396 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 4.020387e-01 0.396 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.045186e-01 0.393 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.045186e-01 0.393 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.045186e-01 0.393 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.045186e-01 0.393 0 0
Regulation of gap junction activity R-HSA-191650 4.045186e-01 0.393 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.045186e-01 0.393 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.045186e-01 0.393 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.045186e-01 0.393 0 0
NADE modulates death signalling R-HSA-205025 4.045186e-01 0.393 0 0
Serine metabolism R-HSA-977347 4.125812e-01 0.384 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.158653e-01 0.381 0 0
G0 and Early G1 R-HSA-1538133 4.158653e-01 0.381 0 0
Neurexins and neuroligins R-HSA-6794361 4.161542e-01 0.381 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.165921e-01 0.380 0 0
Translation of Structural Proteins R-HSA-9683701 4.165921e-01 0.380 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.172478e-01 0.380 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.242262e-01 0.372 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.275427e-01 0.369 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.289802e-01 0.368 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.316552e-01 0.365 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.316552e-01 0.365 0 0
Co-inhibition by PD-1 R-HSA-389948 4.318252e-01 0.365 0 0
MAPK family signaling cascades R-HSA-5683057 4.319726e-01 0.365 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.330062e-01 0.364 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.333412e-01 0.363 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.349245e-01 0.362 0 0
FGFR2 alternative splicing R-HSA-6803529 4.352588e-01 0.361 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.352588e-01 0.361 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.362998e-01 0.360 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.519986e-01 0.345 0 0
Cellular response to starvation R-HSA-9711097 4.528222e-01 0.344 0 0
IRS activation R-HSA-74713 4.538171e-01 0.343 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 4.538171e-01 0.343 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.538171e-01 0.343 0 0
Activation of AKT2 R-HSA-165158 4.538171e-01 0.343 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.538171e-01 0.343 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 4.538171e-01 0.343 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.538171e-01 0.343 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.538171e-01 0.343 0 0
NrCAM interactions R-HSA-447038 4.538171e-01 0.343 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 4.538171e-01 0.343 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.538171e-01 0.343 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.560243e-01 0.341 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.576011e-01 0.340 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.576011e-01 0.340 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.576011e-01 0.340 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.604689e-01 0.337 0 0
HDL assembly R-HSA-8963896 4.604689e-01 0.337 0 0
Signal regulatory protein family interactions R-HSA-391160 4.604689e-01 0.337 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.604689e-01 0.337 0 0
Signaling by NOTCH3 R-HSA-9012852 4.612690e-01 0.336 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.627916e-01 0.335 0 0
Antigen processing-Cross presentation R-HSA-1236975 4.627916e-01 0.335 0 0
ABC transporter disorders R-HSA-5619084 4.650773e-01 0.332 0 0
Cyclin D associated events in G1 R-HSA-69231 4.664968e-01 0.331 0 0
G1 Phase R-HSA-69236 4.664968e-01 0.331 0 0
Signaling by TGFB family members R-HSA-9006936 4.705683e-01 0.327 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.724730e-01 0.326 0 0
eNOS activation R-HSA-203615 4.724730e-01 0.326 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.724730e-01 0.326 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.735521e-01 0.325 0 0
NRAGE signals death through JNK R-HSA-193648 4.761244e-01 0.322 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.761244e-01 0.322 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.791100e-01 0.320 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.791100e-01 0.320 0 0
Deadenylation of mRNA R-HSA-429947 4.795587e-01 0.319 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.795587e-01 0.319 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.795587e-01 0.319 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.795587e-01 0.319 0 0
Neurodegenerative Diseases R-HSA-8863678 4.795587e-01 0.319 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 4.884096e-01 0.311 0 0
Biotin transport and metabolism R-HSA-196780 4.884096e-01 0.311 0 0
Formation of the anterior neural plate R-HSA-9823739 4.884096e-01 0.311 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.908965e-01 0.309 0 0
PERK regulates gene expression R-HSA-381042 4.908965e-01 0.309 0 0
Reproduction R-HSA-1474165 4.939530e-01 0.306 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.990347e-01 0.302 0 0
Diseases of DNA repair R-HSA-9675135 4.990347e-01 0.302 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.990370e-01 0.302 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 4.990370e-01 0.302 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 4.990370e-01 0.302 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.990370e-01 0.302 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 4.990370e-01 0.302 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.990370e-01 0.302 0 0
PKB-mediated events R-HSA-109703 4.990370e-01 0.302 0 0
PDE3B signalling R-HSA-165160 4.990370e-01 0.302 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.990370e-01 0.302 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.990370e-01 0.302 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.990370e-01 0.302 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.990370e-01 0.302 0 0
Selenocysteine synthesis R-HSA-2408557 5.010753e-01 0.300 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.010886e-01 0.300 0 0
Interleukin-7 signaling R-HSA-1266695 5.010886e-01 0.300 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.054536e-01 0.296 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.054536e-01 0.296 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.096559e-01 0.293 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.096559e-01 0.293 0 0
Interleukin-17 signaling R-HSA-448424 5.108052e-01 0.292 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.108052e-01 0.292 0 0
Circadian clock R-HSA-9909396 5.134177e-01 0.290 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.150177e-01 0.288 0 0
Phosphorylation of the APC/C R-HSA-176412 5.154246e-01 0.288 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.154246e-01 0.288 0 0
Prolonged ERK activation events R-HSA-169893 5.154246e-01 0.288 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.154246e-01 0.288 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.154246e-01 0.288 0 0
Virus Assembly and Release R-HSA-168268 5.154246e-01 0.288 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.154309e-01 0.288 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.161262e-01 0.287 0 0
Peroxisomal protein import R-HSA-9033241 5.198951e-01 0.284 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.221535e-01 0.282 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.221535e-01 0.282 0 0
Viral mRNA Translation R-HSA-192823 5.232314e-01 0.281 0 0
Hedgehog 'on' state R-HSA-5632684 5.240784e-01 0.281 0 0
Co-stimulation by CD28 R-HSA-389356 5.307842e-01 0.275 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 5.370379e-01 0.270 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.405155e-01 0.267 0 0
Signaling by LTK in cancer R-HSA-9842640 5.405155e-01 0.267 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.405155e-01 0.267 0 0
STAT5 Activation R-HSA-9645135 5.405155e-01 0.267 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.405155e-01 0.267 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.405155e-01 0.267 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.405155e-01 0.267 0 0
CREB phosphorylation R-HSA-199920 5.405155e-01 0.267 0 0
Neurofascin interactions R-HSA-447043 5.405155e-01 0.267 0 0
VLDL assembly R-HSA-8866423 5.405155e-01 0.267 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.414756e-01 0.266 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.414756e-01 0.266 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.414756e-01 0.266 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.427219e-01 0.265 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.482590e-01 0.261 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.521177e-01 0.258 0 0
HCMV Infection R-HSA-9609646 5.552125e-01 0.256 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.610991e-01 0.251 0 0
RAS processing R-HSA-9648002 5.616184e-01 0.251 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.616184e-01 0.251 0 0
Heme signaling R-HSA-9707616 5.621553e-01 0.250 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.627674e-01 0.250 0 0
Signaling by FGFR in disease R-HSA-1226099 5.630292e-01 0.249 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.640907e-01 0.249 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.665371e-01 0.247 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.665371e-01 0.247 0 0
Specification of primordial germ cells R-HSA-9827857 5.665371e-01 0.247 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.665371e-01 0.247 0 0
Signaling by NOTCH R-HSA-157118 5.677869e-01 0.246 0 0
Gene Silencing by RNA R-HSA-211000 5.770770e-01 0.239 0 0
Glucose metabolism R-HSA-70326 5.778655e-01 0.238 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.785620e-01 0.238 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.785620e-01 0.238 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 5.785620e-01 0.238 0 0
SOS-mediated signalling R-HSA-112412 5.785620e-01 0.238 0 0
PTK6 Expression R-HSA-8849473 5.785620e-01 0.238 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.785620e-01 0.238 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.785620e-01 0.238 0 0
LDL remodeling R-HSA-8964041 5.785620e-01 0.238 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.785620e-01 0.238 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.785620e-01 0.238 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.785620e-01 0.238 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.804136e-01 0.236 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.913626e-01 0.228 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.913626e-01 0.228 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.069243e-01 0.217 0 0
Intra-Golgi traffic R-HSA-6811438 6.109658e-01 0.214 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.120646e-01 0.213 0 0
phospho-PLA2 pathway R-HSA-111995 6.134601e-01 0.212 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.134601e-01 0.212 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.134601e-01 0.212 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.134601e-01 0.212 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.134601e-01 0.212 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.134601e-01 0.212 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.134601e-01 0.212 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.134601e-01 0.212 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.134601e-01 0.212 0 0
Sodium/Proton exchangers R-HSA-425986 6.134601e-01 0.212 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.134601e-01 0.212 0 0
Interleukin-23 signaling R-HSA-9020933 6.134601e-01 0.212 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.136415e-01 0.212 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.136415e-01 0.212 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.136415e-01 0.212 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.136415e-01 0.212 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.253861e-01 0.204 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.300911e-01 0.201 0 0
Protein hydroxylation R-HSA-9629569 6.356813e-01 0.197 0 0
Formation of definitive endoderm R-HSA-9823730 6.356813e-01 0.197 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.360021e-01 0.197 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.361763e-01 0.196 0 0
Signaling by MET R-HSA-6806834 6.361763e-01 0.196 0 0
Signaling by FGFR2 R-HSA-5654738 6.361763e-01 0.196 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.373521e-01 0.196 0 0
Signaling by FGFR4 R-HSA-5654743 6.418897e-01 0.193 0 0
Transmission across Chemical Synapses R-HSA-112315 6.442932e-01 0.191 0 0
Lipophagy R-HSA-9613354 6.454704e-01 0.190 0 0
WNT mediated activation of DVL R-HSA-201688 6.454704e-01 0.190 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.454704e-01 0.190 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.454704e-01 0.190 0 0
Interleukin-1 processing R-HSA-448706 6.454704e-01 0.190 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.454704e-01 0.190 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.454704e-01 0.190 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.454704e-01 0.190 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.454704e-01 0.190 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.454704e-01 0.190 0 0
Generic Transcription Pathway R-HSA-212436 6.499176e-01 0.187 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.545420e-01 0.184 0 0
Cardiogenesis R-HSA-9733709 6.545420e-01 0.184 0 0
G-protein beta:gamma signalling R-HSA-397795 6.545420e-01 0.184 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.567224e-01 0.183 0 0
Lagging Strand Synthesis R-HSA-69186 6.567224e-01 0.183 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.567224e-01 0.183 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.567224e-01 0.183 0 0
Opioid Signalling R-HSA-111885 6.604753e-01 0.180 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.651324e-01 0.177 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.711389e-01 0.173 0 0
Signaling by FGFR3 R-HSA-5654741 6.711553e-01 0.173 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.748316e-01 0.171 0 0
PI3K/AKT activation R-HSA-198203 6.748316e-01 0.171 0 0
Binding and entry of HIV virion R-HSA-173107 6.748316e-01 0.171 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.748316e-01 0.171 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.748316e-01 0.171 0 0
DNA replication initiation R-HSA-68952 6.748316e-01 0.171 0 0
Signal attenuation R-HSA-74749 6.748316e-01 0.171 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.748316e-01 0.171 0 0
Interleukin-27 signaling R-HSA-9020956 6.748316e-01 0.171 0 0
Maturation of spike protein R-HSA-9683686 6.748316e-01 0.171 0 0
Signaling by Leptin R-HSA-2586552 6.748316e-01 0.171 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.748316e-01 0.171 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.752361e-01 0.171 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.767789e-01 0.170 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.767789e-01 0.170 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.860357e-01 0.164 0 0
Extension of Telomeres R-HSA-180786 6.860357e-01 0.164 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.871425e-01 0.163 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.871425e-01 0.163 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.871425e-01 0.163 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.871425e-01 0.163 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.958697e-01 0.157 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.958697e-01 0.157 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.958697e-01 0.157 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.963427e-01 0.157 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.982682e-01 0.156 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.987283e-01 0.156 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.017627e-01 0.154 0 0
Chylomicron assembly R-HSA-8963888 7.017627e-01 0.154 0 0
Synthesis of PI R-HSA-1483226 7.017627e-01 0.154 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.017627e-01 0.154 0 0
Transport of RCbl within the body R-HSA-9758890 7.017627e-01 0.154 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.017627e-01 0.154 0 0
LGI-ADAM interactions R-HSA-5682910 7.017627e-01 0.154 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.017627e-01 0.154 0 0
Suppression of apoptosis R-HSA-9635465 7.017627e-01 0.154 0 0
PECAM1 interactions R-HSA-210990 7.017627e-01 0.154 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.017627e-01 0.154 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.017627e-01 0.154 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 7.025551e-01 0.153 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.045915e-01 0.152 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.067138e-01 0.151 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.111136e-01 0.148 0 0
GPER1 signaling R-HSA-9634597 7.118761e-01 0.148 0 0
NGF-stimulated transcription R-HSA-9031628 7.118761e-01 0.148 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.140170e-01 0.146 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.173812e-01 0.144 0 0
Pyruvate metabolism R-HSA-70268 7.218201e-01 0.142 0 0
Adipogenesis R-HSA-9843745 7.226276e-01 0.141 0 0
Toll-like Receptor Cascades R-HSA-168898 7.258087e-01 0.139 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.264649e-01 0.139 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.264649e-01 0.139 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.264649e-01 0.139 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.264649e-01 0.139 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.264649e-01 0.139 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.264649e-01 0.139 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.312462e-01 0.136 0 0
Complex III assembly R-HSA-9865881 7.312462e-01 0.136 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.329646e-01 0.135 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.415880e-01 0.130 0 0
Inositol phosphate metabolism R-HSA-1483249 7.423729e-01 0.129 0 0
Laminin interactions R-HSA-3000157 7.475849e-01 0.126 0 0
Tight junction interactions R-HSA-420029 7.475849e-01 0.126 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.475849e-01 0.126 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.491223e-01 0.125 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.491223e-01 0.125 0 0
Polymerase switching R-HSA-69091 7.491223e-01 0.125 0 0
Leading Strand Synthesis R-HSA-69109 7.491223e-01 0.125 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.491223e-01 0.125 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.491223e-01 0.125 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.491223e-01 0.125 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.491223e-01 0.125 0 0
OAS antiviral response R-HSA-8983711 7.491223e-01 0.125 0 0
Interleukin-35 Signalling R-HSA-8984722 7.491223e-01 0.125 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.491223e-01 0.125 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.584137e-01 0.120 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.602443e-01 0.119 0 0
MET activates PTK2 signaling R-HSA-8874081 7.630622e-01 0.117 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.630622e-01 0.117 0 0
Sphingolipid catabolism R-HSA-9845614 7.630622e-01 0.117 0 0
Formation of axial mesoderm R-HSA-9796292 7.699043e-01 0.114 0 0
Frs2-mediated activation R-HSA-170968 7.699043e-01 0.114 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.699043e-01 0.114 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.699043e-01 0.114 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.699043e-01 0.114 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.699043e-01 0.114 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.709745e-01 0.113 0 0
Diseases of Immune System R-HSA-5260271 7.709745e-01 0.113 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.710887e-01 0.113 0 0
Neutrophil degranulation R-HSA-6798695 7.722687e-01 0.112 0 0
Post-translational protein modification R-HSA-597592 7.737369e-01 0.111 0 0
Signaling by WNT R-HSA-195721 7.740724e-01 0.111 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.746720e-01 0.111 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.763131e-01 0.110 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.777088e-01 0.109 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.777088e-01 0.109 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.777088e-01 0.109 0 0
Triglyceride biosynthesis R-HSA-75109 7.777088e-01 0.109 0 0
Amyloid fiber formation R-HSA-977225 7.792431e-01 0.108 0 0
Platelet degranulation R-HSA-114608 7.812675e-01 0.107 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.819489e-01 0.107 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.889658e-01 0.103 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.889658e-01 0.103 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.889658e-01 0.103 0 0
Hydrolysis of LPC R-HSA-1483115 7.889658e-01 0.103 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.889658e-01 0.103 0 0
Physiological factors R-HSA-5578768 7.889658e-01 0.103 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.889658e-01 0.103 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.889658e-01 0.103 0 0
Zinc transporters R-HSA-435354 7.889658e-01 0.103 0 0
Ion channel transport R-HSA-983712 7.914765e-01 0.102 0 0
Telomere Extension By Telomerase R-HSA-171319 7.915560e-01 0.102 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.915560e-01 0.102 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.915560e-01 0.102 0 0
Pyroptosis R-HSA-5620971 7.915560e-01 0.102 0 0
Scavenging by Class A Receptors R-HSA-3000480 7.944908e-01 0.100 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.944908e-01 0.100 0 0
Rab regulation of trafficking R-HSA-9007101 7.959665e-01 0.099 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.964501e-01 0.099 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.964501e-01 0.099 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.004187e-01 0.097 0 0
Protein localization R-HSA-9609507 8.010337e-01 0.096 0 0
Signaling by FGFR1 R-HSA-5654736 8.020626e-01 0.096 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.046358e-01 0.094 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.054730e-01 0.094 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.064493e-01 0.093 0 0
Erythropoietin activates RAS R-HSA-9027284 8.064493e-01 0.093 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.064493e-01 0.093 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.064493e-01 0.093 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.064493e-01 0.093 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.064493e-01 0.093 0 0
Transport and metabolism of PAPS R-HSA-174362 8.064493e-01 0.093 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.064493e-01 0.093 0 0
Other semaphorin interactions R-HSA-416700 8.064493e-01 0.093 0 0
DNA Damage Reversal R-HSA-73942 8.064493e-01 0.093 0 0
SLC transporter disorders R-HSA-5619102 8.071173e-01 0.093 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.169802e-01 0.088 0 0
DAP12 signaling R-HSA-2424491 8.169802e-01 0.088 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.169802e-01 0.088 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.169802e-01 0.088 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.169802e-01 0.088 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.193736e-01 0.087 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.224854e-01 0.085 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.224854e-01 0.085 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.224854e-01 0.085 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.224854e-01 0.085 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.224854e-01 0.085 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.224854e-01 0.085 0 0
Killing mechanisms R-HSA-9664420 8.224854e-01 0.085 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.224854e-01 0.085 0 0
Activation of SMO R-HSA-5635838 8.224854e-01 0.085 0 0
Telomere Maintenance R-HSA-157579 8.224927e-01 0.085 0 0
Adaptive Immune System R-HSA-1280218 8.245239e-01 0.084 0 0
Proteasome assembly R-HSA-9907900 8.259564e-01 0.083 0 0
Netrin-1 signaling R-HSA-373752 8.259564e-01 0.083 0 0
Amine ligand-binding receptors R-HSA-375280 8.259564e-01 0.083 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.267205e-01 0.083 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.274147e-01 0.082 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.286212e-01 0.082 0 0
Cargo concentration in the ER R-HSA-5694530 8.286212e-01 0.082 0 0
Downstream signal transduction R-HSA-186763 8.286212e-01 0.082 0 0
tRNA processing R-HSA-72306 8.291212e-01 0.081 0 0
Triglyceride metabolism R-HSA-8979227 8.293834e-01 0.081 0 0
Regulation of beta-cell development R-HSA-186712 8.293834e-01 0.081 0 0
Signaling by FGFR R-HSA-190236 8.294115e-01 0.081 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.343164e-01 0.079 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.354875e-01 0.078 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.354875e-01 0.078 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.371936e-01 0.077 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.371936e-01 0.077 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.371936e-01 0.077 0 0
Fibronectin matrix formation R-HSA-1566977 8.371936e-01 0.077 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.371936e-01 0.077 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.371936e-01 0.077 0 0
Synthesis of PG R-HSA-1483148 8.371936e-01 0.077 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.371936e-01 0.077 0 0
Coenzyme A biosynthesis R-HSA-196783 8.371936e-01 0.077 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.395906e-01 0.076 0 0
Diseases of programmed cell death R-HSA-9645723 8.418763e-01 0.075 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.426240e-01 0.074 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.457978e-01 0.073 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.491844e-01 0.071 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.499198e-01 0.071 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.506840e-01 0.070 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.506840e-01 0.070 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.506840e-01 0.070 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.506840e-01 0.070 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.506840e-01 0.070 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.506840e-01 0.070 0 0
Synthesis of PC R-HSA-1483191 8.532050e-01 0.069 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.534929e-01 0.069 0 0
Mitochondrial protein import R-HSA-1268020 8.534929e-01 0.069 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.534929e-01 0.069 0 0
Signaling by PDGF R-HSA-186797 8.534929e-01 0.069 0 0
Base Excision Repair R-HSA-73884 8.550611e-01 0.068 0 0
Translation of Structural Proteins R-HSA-9694635 8.567114e-01 0.067 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.596395e-01 0.066 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.596395e-01 0.066 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.596395e-01 0.066 0 0
Selenoamino acid metabolism R-HSA-2408522 8.600265e-01 0.065 0 0
Metal ion SLC transporters R-HSA-425410 8.614224e-01 0.065 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.630573e-01 0.064 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.630573e-01 0.064 0 0
Platelet sensitization by LDL R-HSA-432142 8.630573e-01 0.064 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.630573e-01 0.064 0 0
Mismatch Repair R-HSA-5358508 8.630573e-01 0.064 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.630573e-01 0.064 0 0
Integrin cell surface interactions R-HSA-216083 8.633509e-01 0.064 0 0
G alpha (12/13) signalling events R-HSA-416482 8.633509e-01 0.064 0 0
IGF1R signaling cascade R-HSA-2428924 8.679068e-01 0.062 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.679739e-01 0.061 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.687798e-01 0.061 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.687798e-01 0.061 0 0
Chemokine receptors bind chemokines R-HSA-380108 8.692329e-01 0.061 0 0
Parasite infection R-HSA-9664407 8.694117e-01 0.061 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.694117e-01 0.061 0 0
Leishmania phagocytosis R-HSA-9664417 8.694117e-01 0.061 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.697299e-01 0.061 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.744060e-01 0.058 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.744060e-01 0.058 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.744060e-01 0.058 0 0
The NLRP3 inflammasome R-HSA-844456 8.744060e-01 0.058 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.744060e-01 0.058 0 0
Specification of the neural plate border R-HSA-9834899 8.744060e-01 0.058 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.744060e-01 0.058 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.746453e-01 0.058 0 0
PI3K Cascade R-HSA-109704 8.766521e-01 0.057 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.773698e-01 0.057 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.773698e-01 0.057 0 0
Signalling to ERKs R-HSA-187687 8.773698e-01 0.057 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.817342e-01 0.055 0 0
Meiotic recombination R-HSA-912446 8.836952e-01 0.054 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.848147e-01 0.053 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.848147e-01 0.053 0 0
Creatine metabolism R-HSA-71288 8.848147e-01 0.053 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.848147e-01 0.053 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.848147e-01 0.053 0 0
Pregnenolone biosynthesis R-HSA-196108 8.848147e-01 0.053 0 0
RUNX2 regulates bone development R-HSA-8941326 8.854381e-01 0.053 0 0
GPVI-mediated activation cascade R-HSA-114604 8.854381e-01 0.053 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.854381e-01 0.053 0 0
Triglyceride catabolism R-HSA-163560 8.854381e-01 0.053 0 0
RET signaling R-HSA-8853659 8.854381e-01 0.053 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.854381e-01 0.053 0 0
Cardiac conduction R-HSA-5576891 8.867138e-01 0.052 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.872342e-01 0.052 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.930120e-01 0.049 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.943615e-01 0.048 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.943615e-01 0.048 0 0
ERK/MAPK targets R-HSA-198753 8.943615e-01 0.048 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.943615e-01 0.048 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.943615e-01 0.048 0 0
Infectious disease R-HSA-5663205 8.958547e-01 0.048 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.967134e-01 0.047 0 0
MET promotes cell motility R-HSA-8875878 9.001181e-01 0.046 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.001181e-01 0.046 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.031174e-01 0.044 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.031174e-01 0.044 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.067818e-01 0.042 0 0
Gastrulation R-HSA-9758941 9.104148e-01 0.041 0 0
Cellular hexose transport R-HSA-189200 9.111482e-01 0.040 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.111482e-01 0.040 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.130277e-01 0.040 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.154281e-01 0.038 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.154281e-01 0.038 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.154281e-01 0.038 0 0
Neuronal System R-HSA-112316 9.177826e-01 0.037 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.185136e-01 0.037 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.185136e-01 0.037 0 0
Formation of the ureteric bud R-HSA-9830674 9.185136e-01 0.037 0 0
Growth hormone receptor signaling R-HSA-982772 9.185136e-01 0.037 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.188791e-01 0.037 0 0
IRS-mediated signalling R-HSA-112399 9.188844e-01 0.037 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.237027e-01 0.034 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.243586e-01 0.034 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.252689e-01 0.034 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.252689e-01 0.034 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.252689e-01 0.034 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.252689e-01 0.034 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.252689e-01 0.034 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.256986e-01 0.034 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.282575e-01 0.032 0 0
Neurotransmitter release cycle R-HSA-112310 9.284983e-01 0.032 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.294875e-01 0.032 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.314646e-01 0.031 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.314646e-01 0.031 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.314646e-01 0.031 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.314646e-01 0.031 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.319299e-01 0.031 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.321226e-01 0.031 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.343536e-01 0.029 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.343536e-01 0.029 0 0
RSV-host interactions R-HSA-9833110 9.343536e-01 0.029 0 0
Aquaporin-mediated transport R-HSA-445717 9.366258e-01 0.028 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.371469e-01 0.028 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.371469e-01 0.028 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.371469e-01 0.028 0 0
Urea cycle R-HSA-70635 9.371469e-01 0.028 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.371469e-01 0.028 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.371469e-01 0.028 0 0
DAP12 interactions R-HSA-2172127 9.387746e-01 0.027 0 0
Surfactant metabolism R-HSA-5683826 9.387746e-01 0.027 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.388823e-01 0.027 0 0
Cristae formation R-HSA-8949613 9.423585e-01 0.026 0 0
Insulin processing R-HSA-264876 9.423585e-01 0.026 0 0
Synthesis of PE R-HSA-1483213 9.423585e-01 0.026 0 0
Somitogenesis R-HSA-9824272 9.429707e-01 0.026 0 0
Stimuli-sensing channels R-HSA-2672351 9.461754e-01 0.024 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.468923e-01 0.024 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.468923e-01 0.024 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.468923e-01 0.024 0 0
Insulin receptor recycling R-HSA-77387 9.471381e-01 0.024 0 0
Inflammasomes R-HSA-622312 9.471381e-01 0.024 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.471381e-01 0.024 0 0
Insulin receptor signalling cascade R-HSA-74751 9.474997e-01 0.023 0 0
Hemostasis R-HSA-109582 9.491326e-01 0.023 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.495067e-01 0.023 0 0
Signaling by Erythropoietin R-HSA-9006335 9.515218e-01 0.022 0 0
Thyroxine biosynthesis R-HSA-209968 9.515218e-01 0.022 0 0
Platelet calcium homeostasis R-HSA-418360 9.515218e-01 0.022 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.532087e-01 0.021 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.537556e-01 0.021 0 0
Gluconeogenesis R-HSA-70263 9.539775e-01 0.020 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.547843e-01 0.020 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.555421e-01 0.020 0 0
Neurotransmitter clearance R-HSA-112311 9.555421e-01 0.020 0 0
Regulation of insulin secretion R-HSA-422356 9.580281e-01 0.019 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.582492e-01 0.019 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.601532e-01 0.018 0 0
Cellular response to chemical stress R-HSA-9711123 9.616024e-01 0.017 0 0
The phototransduction cascade R-HSA-2514856 9.629349e-01 0.016 0 0
PI Metabolism R-HSA-1483255 9.663304e-01 0.015 0 0
ECM proteoglycans R-HSA-3000178 9.664775e-01 0.015 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.670154e-01 0.015 0 0
Metabolism of proteins R-HSA-392499 9.678407e-01 0.014 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.685563e-01 0.014 0 0
Heme degradation R-HSA-189483 9.685563e-01 0.014 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.688848e-01 0.014 0 0
Mitochondrial biogenesis R-HSA-1592230 9.694647e-01 0.013 0 0
Extracellular matrix organization R-HSA-1474244 9.701322e-01 0.013 0 0
Ca2+ pathway R-HSA-4086398 9.705755e-01 0.013 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.711647e-01 0.013 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.711647e-01 0.013 0 0
Signal amplification R-HSA-392518 9.711647e-01 0.013 0 0
Neddylation R-HSA-8951664 9.740737e-01 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.742646e-01 0.011 0 0
Signaling by NTRKs R-HSA-166520 9.743574e-01 0.011 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.753258e-01 0.011 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.753258e-01 0.011 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.757507e-01 0.011 0 0
G1/S-Specific Transcription R-HSA-69205 9.757507e-01 0.011 0 0
Signaling by Insulin receptor R-HSA-74752 9.760647e-01 0.011 0 0
Synthesis of PA R-HSA-1483166 9.760889e-01 0.011 0 0
Voltage gated Potassium channels R-HSA-1296072 9.777627e-01 0.010 0 0
Metabolism of folate and pterines R-HSA-196757 9.777627e-01 0.010 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.788196e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.788196e-01 0.009 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.793694e-01 0.009 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.796079e-01 0.009 0 0
RAB geranylgeranylation R-HSA-8873719 9.808417e-01 0.008 0 0
tRNA Aminoacylation R-HSA-379724 9.808417e-01 0.008 0 0
Metabolism of polyamines R-HSA-351202 9.808417e-01 0.008 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.822118e-01 0.008 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.828518e-01 0.008 0 0
Tryptophan catabolism R-HSA-71240 9.828518e-01 0.008 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.828518e-01 0.008 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.834866e-01 0.007 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.834866e-01 0.007 0 0
HCMV Late Events R-HSA-9610379 9.835993e-01 0.007 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.838298e-01 0.007 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.842749e-01 0.007 0 0
Maturation of spike protein R-HSA-9694548 9.842749e-01 0.007 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.855800e-01 0.006 0 0
Leishmania infection R-HSA-9658195 9.865033e-01 0.006 0 0
Parasitic Infection Pathways R-HSA-9824443 9.865033e-01 0.006 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.867769e-01 0.006 0 0
Depyrimidination R-HSA-73928 9.867769e-01 0.006 0 0
Defective pyroptosis R-HSA-9710421 9.878745e-01 0.005 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.878745e-01 0.005 0 0
TBC/RABGAPs R-HSA-8854214 9.878745e-01 0.005 0 0
Signaling by SCF-KIT R-HSA-1433557 9.878745e-01 0.005 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.884645e-01 0.005 0 0
Disease R-HSA-1643685 9.887553e-01 0.005 0 0
Immune System R-HSA-168256 9.887802e-01 0.005 0 0
Methylation R-HSA-156581 9.888810e-01 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.888810e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.894633e-01 0.005 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.898041e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.909391e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.909391e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.915992e-01 0.004 0 0
Metabolism of cofactors R-HSA-8978934 9.915992e-01 0.004 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.916659e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.921386e-01 0.003 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.922122e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.923312e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.931356e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.933900e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.937993e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.939389e-01 0.003 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.939389e-01 0.003 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.950696e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.950696e-01 0.002 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.953271e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.954331e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.956961e-01 0.002 0 0
G alpha (z) signalling events R-HSA-418597 9.957153e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.959289e-01 0.002 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.960712e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.963976e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.966849e-01 0.001 0 0
Integration of energy metabolism R-HSA-163685 9.969007e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.970696e-01 0.001 1 1
Collagen degradation R-HSA-1442490 9.974537e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.978062e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.980673e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.981541e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.982702e-01 0.001 0 0
Kidney development R-HSA-9830369 9.984871e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.984871e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.985027e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.985705e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.986129e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.986770e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.988150e-01 0.001 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.988339e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.989309e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.989309e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.990328e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.991013e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.991760e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.994178e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.994425e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.994613e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.995938e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.996216e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.996543e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997434e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997595e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997595e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998118e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.998307e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998427e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.998481e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998557e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998671e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.998762e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999061e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999210e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999211e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999260e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999627e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999722e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999748e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999767e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999850e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999862e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999908e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999931e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999939e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999942e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999944e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999959e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999962e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999962e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999979e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999984e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999993e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999994e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999999e-01 0.000 1 1
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 1 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 1 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways