CAMKK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O00151 T94 Sugiyama PDLIM1 CLIM1 CLP36 TDNLtLtVARsEHKVWsPLVtEEGKRHPYKMNLASEPQEVL
O14818 T152 Sugiyama PSMA7 HSPC LIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFL
O14818 Y145 Sugiyama PSMA7 HSPC RPFGISALIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGA
O14950 T128 Sugiyama MYL12B MRLC2 MYLC2B ACFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPI
O14950 T129 Sugiyama MYL12B MRLC2 MYLC2B CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID
O14950 T160 Sugiyama MYL12B MRLC2 MYLC2B DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O43399 T146 Sugiyama TPD52L2 yKKTQETLsQAGQKtsAALstVGsAIsRKLGDMRNsAtFKs
O43707 T443 Sugiyama ACTN4 sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O95373 T968 Sugiyama IPO7 RANBP7 IIDDEDNPVDEYQIFKAIFQtIQNRNPVWyQALTHGLNEEQ
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04040 T29 Sugiyama CAT SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 T223 Sugiyama ANXA1 ANX1 LPC1 ARALyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKY
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 T174 Sugiyama HSPB1 HSP27 HSP28 SSsLsPEGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGP
P05198 T281 Sugiyama EIF2S1 EIF2A KIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVD
P05387 S29 Sugiyama RPLP2 D11S2243E RPP2 LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06744 T248 Sugiyama GPI WFLQAAKDPSAVAKHFVALstNttKVKEFGIDPQNMFEFWD
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07814 T746 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 NETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVRE
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 T94 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KELHINLIPNKQDRtLtIVDtGIGMTKADLINNLGtIAKSG
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 T401 Sugiyama SLC3A2 MDU1 NSSDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQ
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08865 T94 Sugiyama RPSA LAMBR LAMR1 VsVIssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQA
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7 S54 Sugiyama TUBA3C TUBA2 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10809 S453 Sugiyama HSPD1 HSP60 EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P12277 S164 Sugiyama CKB CKBB PHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAEQ
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P14618 T195 Sugiyama PKM OIP3 PK2 PK3 PKM2 yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17980 T163 Sugiyama PSMC3 TBP1 EKLKPGDLVGVNKDSyLILEtLPtEyDsRVKAMEVDERPtE
P19105 T127 Sugiyama MYL12A MLCB MRLC3 RLC ACFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPI
P19105 T128 Sugiyama MYL12A MLCB MRLC3 RLC CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID
P19105 T159 Sugiyama MYL12A MLCB MRLC3 RLC DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P20290 T182 Sugiyama BTF3 NACB OK/SW-cl.8 LRRLAEALPKQsVDGKAPLAtGEDDDDEVPDLVENFDEAsK
P23284 T81 Sugiyama PPIB CYPB IFGLFGKTVPKTVDNFVALAtGEKGFGYKNSKFHRVIKDFM
P23381 T362 Sugiyama WARS1 IFI53 WARS WRS ALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFsGGRD
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P30041 T48 Sugiyama PRDX6 AOP2 KIAA0106 FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30043 T191 Sugiyama BLVRB FLR SCAN GPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ_____
P30050 T135 Sugiyama RPL12 QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30626 T130 Sugiyama SRI IsFDTDRSGTVDPQELQKALttMGFRLsPQAVNSIAKRYst
P30626 T131 Sugiyama SRI sFDTDRSGTVDPQELQKALttMGFRLsPQAVNSIAKRYstN
P31749 T308 EPSD|PSP AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40227 S49 Sugiyama CCT6A CCT6 CCTZ GLQDVLRTNLGPKGTMKMLVsGAGDIKLTKDGNVLLHEMQI
P42677 S11 Sugiyama RPS27 MPS1 __________MPLAKDLLHPsPEEEKRKHKKKRLVQsPNsy
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S180 Sugiyama NAMPT PBEF PBEF1 TVATNSREQKKILAKyLLEtsGNLDGLEyKLHDFGyRGVSS
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46778 T29 Sugiyama RPL21 RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49327 T1150 Sugiyama FASN FAS ERAALQEELQLCKGLVQALQtKVTQQGLKMVVPGLDGAQIP
P50990 S373 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 SEVGDTQVVVFKHEKEDGAIstIVLRGstDNLMDDIERAVD
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51149 T168 Sugiyama RAB7A RAB7 NIPyFEtSAKEAINVEQAFQtIARNALKQETEVELyNEFPE
P54646 T172 GPS6|SIGNOR|EPSD|PSP PRKAA2 AMPK AMPK2 NAKIADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60660 T85 Sugiyama MYL6 LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P61163 T101 Sugiyama ACTR1A CTRN1 KDWNDMERIWQYVYSKDQLQtFSEEHPVLLtEAPLNPRKNR
P61163 T111 Sugiyama ACTR1A CTRN1 QYVYSKDQLQtFSEEHPVLLtEAPLNPRKNRERAAEVFFET
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 T70 Sugiyama HNRNPK HNRPK QSKNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsI
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899 T107 Sugiyama RPL31 RLSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN__
P62899 T119 Sugiyama RPL31 PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 S54 Sugiyama TUBA1B GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00839 T530 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 KTTWVTKHAAENPGKyNILGtNtIMDKMMVAGFKKQMADtG
Q01814 T1241 Sugiyama ATP2B2 PMCA2 TDtsKSATSSsPGsPIHSLEtsL__________________
Q06830 T166 Sugiyama PRDX1 PAGA PAGB TDPX2 DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q06830 T18 Sugiyama PRDX1 PAGA PAGB TDPX2 ___MSSGNAKIGHPAPNFKAtAVMPDGQFKDIsLsDyKGKY
Q13131 T183 SIGNOR|EPSD|PSP PRKAA1 AMPK1 NAKIADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14012 T177 GPS6|SIGNOR|iPTMNet CAMK1 KIMISDFGLSKMEDPGSVLstACGTPGYVAPEVLAQKPYSK
Q14444 T303 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15181 T245 Sugiyama PPA1 IOPPP PP DHWKALVTKKTNGKGIsCMNttLsEsPFKCDPDAARAIVDA
Q15181 T246 Sugiyama PPA1 IOPPP PP HWKALVTKKTNGKGIsCMNttLsEsPFKCDPDAARAIVDAL
Q15293 T211 Sugiyama RCN1 RCN FTAFLHPEEFEHMKEIVVLEtLEDIDKNGDGFVDQDEyIAD
Q16566 T200 GPS6|SIGNOR|iPTMNet CAMK4 CAMK CAMK-GR CAMKIV PLKIADFGLsKIVEHQVLMKtVCGTPGYCAPEILRGCAYGP
Q4G0X9 S553 Sugiyama CCDC40 KIAA1640 EIEAYKKSIMKEEEKNEKLAsILNRTETEATLLQKLTTQCL
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FG1 T34 Sugiyama HSP90AA4P HSP90AD HSPCAL2 KEPHISLIPNKQDRtLtIVDtGIGMTKADLINNLGTITKSE
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2 S54 Sugiyama TUBA3E GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 S54 Sugiyama TUBA1A TUBA3 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q86V81 T148 Sugiyama ALYREF ALY BEF THOC4 EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IU85 T180 GPS6 CAMK1D CAMKID KIMISDFGLSKMEGKGDVMstACGtPGYVAPEVLAQKPYSK
Q8IV50 T210 Sugiyama LYSMD2 STQAAKKLKEESRDEEsPyAtSLyHs_______________
Q8NBJ5 S616 Sugiyama COLGALT1 GLT25D1 PSEC0241 EQQALSREAKNsDVLQsPLDsAARDEL______________
Q8NBJ7 S44 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 NGQATSMVQLQGGRFLMGtNsPDSRDGDGPVREATVKPFAI
Q8NBJ7 T260 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96EB6 S27 PSP SIRT1 SIR2L1 LALQPGGsPsAAGADREAAssPAGEPLRKRPRRDGPGLERs
Q96EB6 S47 PSP SIRT1 SIR2L1 sPAGEPLRKRPRRDGPGLERsPGEPGGAAPEREVPAAARGC
Q96RR4 S100 Sugiyama CAMKK2 CAMKKB KIAA0787 EVPLDtsGSQARPHLSGRKLsLQERsQGGLAAGGsLDMNGR
Q96RR4 S105 Sugiyama CAMKK2 CAMKKB KIAA0787 tsGSQARPHLSGRKLsLQERsQGGLAAGGsLDMNGRCICPs
Q96RR4 S114 Sugiyama CAMKK2 CAMKKB KIAA0787 LSGRKLsLQERsQGGLAAGGsLDMNGRCICPsLPysPVssP
Q96RR4 S125 Sugiyama CAMKK2 CAMKKB KIAA0787 sQGGLAAGGsLDMNGRCICPsLPysPVssPQssPRLPRRPT
Q96RR4 S129 Sugiyama CAMKK2 CAMKKB KIAA0787 LAAGGsLDMNGRCICPsLPysPVssPQssPRLPRRPTVESH
Q96RR4 S133 Sugiyama CAMKK2 CAMKKB KIAA0787 GsLDMNGRCICPsLPysPVssPQssPRLPRRPTVESHHVSI
Q96RR4 S136 Sugiyama CAMKK2 CAMKKB KIAA0787 DMNGRCICPsLPysPVssPQssPRLPRRPTVESHHVSITGM
Q96RR4 S137 Sugiyama CAMKK2 CAMKKB KIAA0787 MNGRCICPsLPysPVssPQssPRLPRRPTVESHHVSITGMQ
Q96RR4 S26 Sugiyama CAMKK2 CAMKKB KIAA0787 SSQPSSNRAAPQDELGGRGSsSsEsQKPCEALRGLSSLSIH
Q96RR4 S28 Sugiyama CAMKK2 CAMKKB KIAA0787 QPSSNRAAPQDELGGRGSsSsEsQKPCEALRGLSSLSIHLG
Q96RR4 S30 Sugiyama CAMKK2 CAMKKB KIAA0787 SSNRAAPQDELGGRGSsSsEsQKPCEALRGLSSLSIHLGME
Q96RR4 S503 Sugiyama CAMKK2 CAMKKB KIAA0787 tVILVKTMIRKRsFGNPFEGsRREERSLsAPGNLLTKKPTR
Q96RR4 T216 Sugiyama CAMKK2 CAMKKB KIAA0787 LSKKKLIRQAGFPRRPPPRGtRPAPGGCIQPRGPIEQVYQE
Q96RR4 T483 SIGNOR CAMKK2 CAMKKB KIAA0787 LVEVTEEEVENSVKHIPSLAtVILVKTMIRKRsFGNPFEGs
Q96RR4 T85 EPSD|PSP CAMKK2 CAMKKB KIAA0787 DLGLARDRPLEADGQEVPLDtsGSQARPHLSGRKLsLQERs
Q96RR4 Y128 Sugiyama CAMKK2 CAMKKB KIAA0787 GLAAGGsLDMNGRCICPsLPysPVssPQssPRLPRRPTVES
Q96RU3 T537 Sugiyama FNBP1 FBP17 KIAA0554 sPDGsYTEEQsQESEMKVLAtDFDDEFDDEEPLPAIGTCKA
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 S54 Sugiyama TUBA1C TUBA6 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BUJ2 T113 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 SGPDGHYAMDNITRQNQFyDtQVIKQENESGyERRPLEMEQ
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BXS5 T422 Sugiyama AP1M1 CLTNM GYQALPWVRYITQNGDyQLRtQ___________________
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9UNW1 S468 Sugiyama MINPP1 MIPP UNQ900/PRO1917 SQETVSFYEDLKNHYKDILQsCQTSEECELARANSTSDEL_
Q9Y2W1 T230 Sugiyama THRAP3 BCLAF2 TRAP150 tsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPA
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.448449e-07 6.352 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.018404e-06 5.695 0 0
Post NMDA receptor activation events R-HSA-438064 2.098906e-06 5.678 1 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.519770e-06 5.345 1 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.974657e-06 5.001 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.247647e-05 4.904 0 0
Regulation of TP53 Activity R-HSA-5633007 2.155609e-05 4.666 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.636211e-05 4.579 1 1
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.704268e-05 4.568 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.366312e-05 4.473 0 0
Cell Cycle, Mitotic R-HSA-69278 4.309970e-05 4.366 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.025852e-05 4.299 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.950748e-05 4.305 0 0
Cell Cycle R-HSA-1640170 5.409964e-05 4.267 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.693876e-05 4.174 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 8.150076e-05 4.089 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.609289e-05 4.065 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.799763e-05 4.056 0 0
Membrane Trafficking R-HSA-199991 1.395573e-04 3.855 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.463198e-04 3.835 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.542631e-04 3.812 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.905111e-04 3.720 0 0
Signal Transduction R-HSA-162582 1.865289e-04 3.729 1 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.153347e-04 3.501 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.112603e-04 3.507 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.426161e-04 3.465 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.559062e-04 3.449 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.938974e-04 3.405 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.080086e-04 3.389 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.339276e-04 3.363 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.307470e-04 3.366 0 0
Mitotic Anaphase R-HSA-68882 4.437698e-04 3.353 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.697668e-04 3.328 0 0
Signaling by Hippo R-HSA-2028269 4.965032e-04 3.304 0 0
HDMs demethylate histones R-HSA-3214842 5.266988e-04 3.278 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.522275e-04 3.186 0 0
Separation of Sister Chromatids R-HSA-2467813 6.102101e-04 3.215 0 0
Mitotic Prometaphase R-HSA-68877 6.300750e-04 3.201 0 0
M Phase R-HSA-68886 6.435239e-04 3.191 0 0
Interferon Signaling R-HSA-913531 6.705376e-04 3.174 0 0
PKR-mediated signaling R-HSA-9833482 6.693045e-04 3.174 0 0
Protein folding R-HSA-391251 7.538547e-04 3.123 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.571027e-04 3.121 0 0
Apoptotic execution phase R-HSA-75153 7.858805e-04 3.105 0 0
Rab regulation of trafficking R-HSA-9007101 9.036080e-04 3.044 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.356596e-04 3.029 0 0
Co-stimulation by CD28 R-HSA-389356 1.009944e-03 2.996 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.027397e-03 2.988 0 0
Signaling by ALK in cancer R-HSA-9700206 1.027397e-03 2.988 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.096618e-03 2.960 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.096618e-03 2.960 0 0
RAB geranylgeranylation R-HSA-8873719 1.052771e-03 2.978 0 0
Cellular responses to stimuli R-HSA-8953897 1.145940e-03 2.941 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.302489e-03 2.885 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.412218e-03 2.850 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.412218e-03 2.850 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.686805e-03 2.773 0 0
MTOR signalling R-HSA-165159 1.944760e-03 2.711 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.946701e-03 2.711 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.949271e-03 2.710 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.949271e-03 2.710 0 0
WNT mediated activation of DVL R-HSA-201688 2.122514e-03 2.673 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.154351e-03 2.667 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.163112e-03 2.665 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.232106e-03 2.651 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.515112e-03 2.599 0 0
RAF activation R-HSA-5673000 2.568175e-03 2.590 0 0
Gap junction assembly R-HSA-190861 2.568175e-03 2.590 0 0
Long-term potentiation R-HSA-9620244 2.795222e-03 2.554 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.824681e-03 2.549 1 1
COPI-mediated anterograde transport R-HSA-6807878 3.333910e-03 2.477 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.652284e-03 2.437 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.652284e-03 2.437 0 0
Kinesins R-HSA-983189 3.670061e-03 2.435 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.842092e-03 2.415 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.866527e-03 2.413 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.674910e-03 2.330 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.674910e-03 2.330 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.460352e-03 2.351 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.693712e-03 2.328 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.598184e-03 2.337 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.527907e-03 2.344 0 0
Activation of RAC1 R-HSA-428540 4.674910e-03 2.330 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.587950e-03 2.253 0 0
Disorders of Nervous System Development R-HSA-9697154 5.848309e-03 2.233 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.848309e-03 2.233 0 0
Pervasive developmental disorders R-HSA-9005895 5.848309e-03 2.233 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.848309e-03 2.233 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.848309e-03 2.233 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.848309e-03 2.233 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.848309e-03 2.233 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.848309e-03 2.233 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.404325e-03 2.267 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.587950e-03 2.253 0 0
G2/M Transition R-HSA-69275 5.174453e-03 2.286 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.692998e-03 2.245 0 0
Aggrephagy R-HSA-9646399 5.349024e-03 2.272 0 0
L1CAM interactions R-HSA-373760 5.907441e-03 2.229 0 0
Smooth Muscle Contraction R-HSA-445355 6.313870e-03 2.200 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.492401e-03 2.188 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.650920e-03 2.177 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.202984e-03 2.142 0 0
Signaling by WNT in cancer R-HSA-4791275 7.352737e-03 2.134 0 0
Cellular responses to stress R-HSA-2262752 7.038394e-03 2.153 0 0
Apoptosis R-HSA-109581 7.246500e-03 2.140 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.398048e-03 2.131 0 0
Vesicle-mediated transport R-HSA-5653656 7.519363e-03 2.124 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.546754e-03 2.122 0 0
G-protein beta:gamma signalling R-HSA-397795 8.287272e-03 2.082 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.379576e-03 2.077 1 0
Muscle contraction R-HSA-397014 8.379576e-03 2.077 0 0
Axon guidance R-HSA-422475 7.728218e-03 2.112 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.936060e-03 2.049 0 0
Gap junction trafficking R-HSA-190828 9.026315e-03 2.044 0 0
Striated Muscle Contraction R-HSA-390522 9.304139e-03 2.031 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.854222e-03 2.006 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.854222e-03 2.006 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.023273e-02 1.990 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.023273e-02 1.990 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.049875e-02 1.979 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.092183e-02 1.962 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.092183e-02 1.962 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.092183e-02 1.962 0 0
Signaling by RAS mutants R-HSA-6802949 1.092183e-02 1.962 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.049875e-02 1.979 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.197083e-02 1.922 0 0
Recycling pathway of L1 R-HSA-437239 1.197083e-02 1.922 0 0
Nervous system development R-HSA-9675108 1.228729e-02 1.911 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.378730e-02 1.861 0 0
Regulation of TP53 Expression R-HSA-6804754 1.378730e-02 1.861 0 0
C6 deamination of adenosine R-HSA-75102 1.378730e-02 1.861 0 0
Myogenesis R-HSA-525793 1.450542e-02 1.838 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.378730e-02 1.861 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.343048e-02 1.872 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.318935e-02 1.880 0 0
Gap junction trafficking and regulation R-HSA-157858 1.428378e-02 1.845 0 0
Disorders of Developmental Biology R-HSA-9675151 1.463882e-02 1.834 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.463882e-02 1.834 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.463882e-02 1.834 0 0
Adipogenesis R-HSA-9843745 1.509870e-02 1.821 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.586475e-02 1.800 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.633451e-02 1.787 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.658350e-02 1.780 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.698328e-02 1.770 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.698328e-02 1.770 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.093133e-02 1.679 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.155731e-02 1.666 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.935459e-02 1.713 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.082988e-02 1.681 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.983641e-02 1.703 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.018891e-02 1.695 1 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.211553e-02 1.655 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.272155e-02 1.644 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.272155e-02 1.644 0 0
PTEN Regulation R-HSA-6807070 2.310120e-02 1.636 0 0
Signaling by VEGF R-HSA-194138 2.350689e-02 1.629 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.395012e-02 1.621 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.395012e-02 1.621 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.397611e-02 1.620 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.397611e-02 1.620 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.470536e-02 1.607 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.470536e-02 1.607 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.470536e-02 1.607 0 0
Signaling by APC mutants R-HSA-4839744 2.470536e-02 1.607 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.470536e-02 1.607 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.470536e-02 1.607 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.477177e-02 1.606 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.928899e-02 1.533 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.726858e-02 1.564 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.943532e-02 1.531 0 0
Signaling by AXIN mutants R-HSA-4839735 2.943532e-02 1.531 0 0
Interleukin-12 family signaling R-HSA-447115 2.849361e-02 1.545 0 0
Selective autophagy R-HSA-9663891 3.013396e-02 1.521 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.053676e-02 1.515 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.053676e-02 1.515 0 0
Adaptive Immune System R-HSA-1280218 3.280672e-02 1.484 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.347340e-02 1.475 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.460806e-02 1.461 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.460806e-02 1.461 0 0
Interleukin-12 signaling R-HSA-9020591 3.476736e-02 1.459 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.630921e-02 1.440 0 0
Notch-HLH transcription pathway R-HSA-350054 3.654553e-02 1.437 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 4.307516e-02 1.366 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 4.307516e-02 1.366 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 4.307516e-02 1.366 0 0
Activation of AKT2 R-HSA-165158 3.874275e-02 1.412 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.021801e-02 1.396 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.874275e-02 1.412 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.874275e-02 1.412 0 0
Intraflagellar transport R-HSA-5620924 3.947968e-02 1.404 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.264631e-02 1.370 0 0
G alpha (12/13) signalling events R-HSA-416482 3.899426e-02 1.409 0 0
RUNX2 regulates bone development R-HSA-8941326 4.330821e-02 1.363 0 0
NrCAM interactions R-HSA-447038 3.874275e-02 1.412 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.066927e-02 1.391 0 0
MHC class II antigen presentation R-HSA-2132295 4.324255e-02 1.364 0 0
Programmed Cell Death R-HSA-5357801 4.438968e-02 1.353 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.448967e-02 1.352 0 0
Deadenylation of mRNA R-HSA-429947 4.504621e-02 1.346 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.504621e-02 1.346 0 0
Neuronal System R-HSA-112316 4.589919e-02 1.338 1 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.693288e-02 1.329 0 0
Autophagy R-HSA-9612973 4.790056e-02 1.320 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.900559e-02 1.310 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.900559e-02 1.310 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.900559e-02 1.310 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.918297e-02 1.308 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.918297e-02 1.308 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.455716e-02 1.263 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.927567e-02 1.227 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.927567e-02 1.227 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.958572e-02 1.225 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.455716e-02 1.263 0 0
Neurexins and neuroligins R-HSA-6794361 5.183009e-02 1.285 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.958572e-02 1.225 0 0
Killing mechanisms R-HSA-9664420 5.958572e-02 1.225 0 0
Interferon gamma signaling R-HSA-877300 5.334944e-02 1.273 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.678909e-02 1.246 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.271715e-02 1.278 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.032561e-02 1.298 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.271715e-02 1.278 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.266651e-02 1.278 0 0
Generation of second messenger molecules R-HSA-202433 5.885618e-02 1.230 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.271715e-02 1.278 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.364978e-02 1.270 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.965879e-02 1.224 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.032537e-02 1.220 0 0
Hedgehog 'off' state R-HSA-5610787 6.032537e-02 1.220 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.050736e-02 1.218 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.050736e-02 1.218 0 0
MAPK family signaling cascades R-HSA-5683057 6.110361e-02 1.214 0 0
Cellular Senescence R-HSA-2559583 6.129477e-02 1.213 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.220276e-02 1.206 0 0
Signaling by NOTCH3 R-HSA-9012852 6.247877e-02 1.204 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.302859e-02 1.200 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.318049e-02 1.199 0 0
FLT3 Signaling R-HSA-9607240 6.318049e-02 1.199 0 0
NRAGE signals death through JNK R-HSA-193648 6.629458e-02 1.179 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.685079e-02 1.175 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.429736e-02 1.074 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.429736e-02 1.074 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.429736e-02 1.074 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.429736e-02 1.074 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.429736e-02 1.074 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.429736e-02 1.074 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.262062e-02 1.139 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.262062e-02 1.139 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.262062e-02 1.139 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.068821e-02 1.151 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.655047e-02 1.116 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.076184e-02 1.150 0 0
EGFR downregulation R-HSA-182971 8.264868e-02 1.083 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.251482e-02 1.083 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.251482e-02 1.083 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.262062e-02 1.139 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.024352e-02 1.153 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.853950e-02 1.105 0 0
Signaling by WNT R-HSA-195721 7.452332e-02 1.128 0 0
Regulation of PTEN gene transcription R-HSA-8943724 8.288546e-02 1.082 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.767896e-02 1.170 0 0
Cell Cycle Checkpoints R-HSA-69620 7.088656e-02 1.149 0 0
Mitotic Prophase R-HSA-68875 7.635851e-02 1.117 0 0
Cilium Assembly R-HSA-5617833 8.312789e-02 1.080 0 0
Ca-dependent events R-HSA-111996 7.235063e-02 1.141 1 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.102318e-02 1.149 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.880260e-02 1.162 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.251482e-02 1.083 0 0
Ephrin signaling R-HSA-3928664 8.251482e-02 1.083 0 0
Activation of BH3-only proteins R-HSA-114452 7.655047e-02 1.116 0 0
Trafficking of AMPA receptors R-HSA-399719 8.264868e-02 1.083 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.733087e-02 1.112 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.430820e-02 1.074 0 0
Platelet sensitization by LDL R-HSA-432142 8.251482e-02 1.083 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.220828e-02 1.085 0 0
IRE1alpha activates chaperones R-HSA-381070 8.163828e-02 1.088 0 0
Transmission across Chemical Synapses R-HSA-112315 8.503094e-02 1.070 1 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.505986e-02 1.070 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.543398e-02 1.068 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.543398e-02 1.068 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.543398e-02 1.068 1 1
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.740210e-02 1.058 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.843131e-02 1.053 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.088369e-02 1.042 0 0
Immune System R-HSA-168256 9.115091e-02 1.040 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.389603e-02 1.027 0 0
Macroautophagy R-HSA-1632852 9.442268e-02 1.025 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 9.553325e-02 1.020 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.553325e-02 1.020 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.553325e-02 1.020 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.553325e-02 1.020 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.553325e-02 1.020 0 0
Semaphorin interactions R-HSA-373755 9.670498e-02 1.015 0 0
Signaling by PTK6 R-HSA-8848021 9.670498e-02 1.015 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.670498e-02 1.015 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.744877e-02 1.011 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.825293e-02 1.008 0 0
HCMV Early Events R-HSA-9609690 9.834681e-02 1.007 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 9.886485e-02 1.005 0 0
mRNA Editing R-HSA-75072 9.886485e-02 1.005 0 0
Calcineurin activates NFAT R-HSA-2025928 9.886485e-02 1.005 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 9.886485e-02 1.005 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 9.886485e-02 1.005 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.958921e-02 1.002 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.006525e-01 0.997 0 0
Chromatin modifying enzymes R-HSA-3247509 1.009872e-01 0.996 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.023087e-01 0.990 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.039274e-01 0.983 0 0
IKBKB deficiency causes SCID R-HSA-5602636 1.237462e-01 0.907 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.237462e-01 0.907 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 1.237462e-01 0.907 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 1.237462e-01 0.907 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 1.237462e-01 0.907 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.128364e-01 0.948 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.128364e-01 0.948 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.128364e-01 0.948 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.272774e-01 0.895 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.275575e-01 0.894 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.092982e-01 0.961 0 0
Degradation of DVL R-HSA-4641258 1.314857e-01 0.881 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.314857e-01 0.881 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.116713e-01 0.952 0 0
ESR-mediated signaling R-HSA-8939211 1.086373e-01 0.964 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.275575e-01 0.894 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.119324e-01 0.951 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.393265e-01 0.856 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.316031e-01 0.881 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.237462e-01 0.907 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.272774e-01 0.895 0 0
mTORC1-mediated signalling R-HSA-166208 1.275575e-01 0.894 0 0
Oncogene Induced Senescence R-HSA-2559585 1.164954e-01 0.934 0 0
Interferon alpha/beta signaling R-HSA-909733 1.206599e-01 0.918 0 0
Calmodulin induced events R-HSA-111933 1.238936e-01 0.907 1 0
Gastrulation R-HSA-9758941 1.243181e-01 0.905 0 0
CaM pathway R-HSA-111997 1.238936e-01 0.907 1 0
HSF1-dependent transactivation R-HSA-3371571 1.218896e-01 0.914 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.086147e-01 0.964 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.237462e-01 0.907 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.272774e-01 0.895 0 0
Opioid Signalling R-HSA-111885 1.393265e-01 0.856 1 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.300648e-01 0.886 0 0
Suppression of apoptosis R-HSA-9635465 1.272774e-01 0.895 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.384390e-01 0.859 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 1.392644e-01 0.856 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.272774e-01 0.895 0 0
G1/S-Specific Transcription R-HSA-69205 1.238936e-01 0.907 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.421215e-01 0.847 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.421215e-01 0.847 0 0
Chromatin organization R-HSA-4839726 1.426483e-01 0.846 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.428033e-01 0.845 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.614978e-01 0.792 0 0
DSCAM interactions R-HSA-376172 1.614978e-01 0.792 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 1.614978e-01 0.792 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 1.976252e-01 0.704 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 1.976252e-01 0.704 0 0
HCN channels R-HSA-1296061 2.321982e-01 0.634 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.321982e-01 0.634 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.321982e-01 0.634 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.321982e-01 0.634 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.321982e-01 0.634 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.321982e-01 0.634 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.321982e-01 0.634 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.652834e-01 0.576 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.652834e-01 0.576 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.573073e-01 0.803 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.573073e-01 0.803 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.573073e-01 0.803 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.969449e-01 0.527 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.969449e-01 0.527 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.969449e-01 0.527 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.969449e-01 0.527 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.969449e-01 0.527 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.727781e-01 0.763 0 0
Signaling by LTK in cancer R-HSA-9842640 3.272438e-01 0.485 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.272438e-01 0.485 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 3.272438e-01 0.485 0 0
STAT5 Activation R-HSA-9645135 3.272438e-01 0.485 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 3.272438e-01 0.485 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 3.272438e-01 0.485 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.272438e-01 0.485 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.272438e-01 0.485 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.043677e-01 0.690 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.475732e-01 0.831 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.562388e-01 0.448 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.562388e-01 0.448 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.562388e-01 0.448 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.562388e-01 0.448 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.562388e-01 0.448 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.562388e-01 0.448 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.365160e-01 0.626 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.365160e-01 0.626 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.793022e-01 0.746 0 0
phospho-PLA2 pathway R-HSA-111995 3.839858e-01 0.416 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.839858e-01 0.416 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.472222e-01 0.832 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.689047e-01 0.570 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.013903e-01 0.696 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.553515e-01 0.809 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.126646e-01 0.672 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.851036e-01 0.545 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.105384e-01 0.387 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.105384e-01 0.387 0 0
ALK mutants bind TKIs R-HSA-9700645 4.105384e-01 0.387 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.240707e-01 0.650 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.240707e-01 0.650 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.472153e-01 0.607 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.173632e-01 0.498 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.173632e-01 0.498 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.359481e-01 0.361 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.359481e-01 0.361 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.688179e-01 0.773 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.333727e-01 0.477 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.825391e-01 0.549 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.492716e-01 0.457 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.060077e-01 0.686 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.060077e-01 0.686 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.819750e-01 0.740 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.944189e-01 0.531 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.650398e-01 0.438 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.826420e-01 0.549 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.537341e-01 0.596 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.021472e-01 0.520 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.119574e-01 0.506 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.869311e-01 0.542 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.264667e-01 0.370 0 0
Cristae formation R-HSA-8949613 4.264667e-01 0.370 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.264667e-01 0.370 0 0
Centrosome maturation R-HSA-380287 3.038239e-01 0.517 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.514154e-01 0.454 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.514154e-01 0.454 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.514154e-01 0.454 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.514154e-01 0.454 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.514154e-01 0.454 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.799193e-01 0.553 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.161931e-01 0.665 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.069248e-01 0.390 0 0
Neutrophil degranulation R-HSA-6798695 2.851916e-01 0.545 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.255952e-01 0.647 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.707028e-01 0.568 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.443034e-01 0.612 0 0
Signaling by EGFR R-HSA-177929 1.547461e-01 0.810 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.129805e-01 0.384 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.618940e-01 0.441 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.760355e-01 0.754 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.063291e-01 0.514 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.727781e-01 0.763 0 0
MAP2K and MAPK activation R-HSA-5674135 1.720927e-01 0.764 0 0
DNA Double Strand Break Response R-HSA-5693606 2.375093e-01 0.624 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.182570e-01 0.497 0 0
Interleukin-15 signaling R-HSA-8983432 1.573073e-01 0.803 0 0
GAB1 signalosome R-HSA-180292 2.689047e-01 0.570 0 0
COPII-mediated vesicle transport R-HSA-204005 2.619474e-01 0.582 0 0
Regulation of CDH11 function R-HSA-9762292 4.359481e-01 0.361 0 0
RNA Polymerase III Transcription R-HSA-74158 2.944189e-01 0.531 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.264667e-01 0.370 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.819347e-01 0.550 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.492458e-01 0.457 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.702213e-01 0.568 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.702213e-01 0.568 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.579396e-01 0.802 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.492458e-01 0.457 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.573073e-01 0.803 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.969449e-01 0.527 0 0
Formation of axial mesoderm R-HSA-9796292 1.727781e-01 0.763 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.043677e-01 0.690 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.839858e-01 0.416 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.689047e-01 0.570 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.105384e-01 0.387 0 0
Homology Directed Repair R-HSA-5693538 3.633787e-01 0.440 0 0
Repression of WNT target genes R-HSA-4641265 1.573073e-01 0.803 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.573073e-01 0.803 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.598606e-01 0.585 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.301908e-01 0.481 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.720927e-01 0.764 0 0
Interleukin-2 family signaling R-HSA-451927 3.421188e-01 0.466 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.846519e-01 0.415 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.652834e-01 0.576 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.562388e-01 0.448 0 0
PTK6 Expression R-HSA-8849473 3.562388e-01 0.448 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.365160e-01 0.626 0 0
Integrin signaling R-HSA-354192 2.472153e-01 0.607 0 0
2-LTR circle formation R-HSA-164843 4.359481e-01 0.361 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.224075e-01 0.653 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.799193e-01 0.553 0 0
PCP/CE pathway R-HSA-4086400 3.294217e-01 0.482 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.785509e-01 0.555 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.908108e-01 0.719 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.126646e-01 0.672 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.321982e-01 0.634 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.321982e-01 0.634 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.969449e-01 0.527 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.365160e-01 0.626 0 0
Lipophagy R-HSA-9613354 4.105384e-01 0.387 0 0
Intra-Golgi traffic R-HSA-6811438 3.659135e-01 0.437 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.810899e-01 0.419 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.069224e-01 0.513 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.129805e-01 0.384 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.953571e-01 0.530 0 0
Somitogenesis R-HSA-9824272 2.072802e-01 0.683 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.553515e-01 0.809 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.553515e-01 0.809 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.806589e-01 0.419 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.826420e-01 0.549 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.105384e-01 0.387 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.707028e-01 0.568 0 0
Developmental Cell Lineages R-HSA-9734767 3.673129e-01 0.435 0 0
G2/M Checkpoints R-HSA-69481 2.909250e-01 0.536 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.333727e-01 0.477 0 0
Stabilization of p53 R-HSA-69541 3.301908e-01 0.481 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.351750e-01 0.475 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.357875e-01 0.627 0 0
Signaling by ERBB2 R-HSA-1227986 1.833680e-01 0.737 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.357875e-01 0.627 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.537715e-01 0.596 0 0
Circadian clock R-HSA-9909396 3.292987e-01 0.482 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.855446e-01 0.732 0 0
Dopamine receptors R-HSA-390651 2.321982e-01 0.634 0 0
Reelin signalling pathway R-HSA-8866376 2.652834e-01 0.576 0 0
Suppression of autophagy R-HSA-9636569 2.652834e-01 0.576 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.969449e-01 0.527 0 0
PKB-mediated events R-HSA-109703 2.969449e-01 0.527 0 0
PDE3B signalling R-HSA-165160 2.969449e-01 0.527 0 0
Threonine catabolism R-HSA-8849175 2.969449e-01 0.527 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.727781e-01 0.763 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.272438e-01 0.485 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.562388e-01 0.448 0 0
Netrin mediated repulsion signals R-HSA-418886 3.562388e-01 0.448 0 0
Fructose biosynthesis R-HSA-5652227 3.839858e-01 0.416 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.839858e-01 0.416 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.902640e-01 0.721 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.902640e-01 0.721 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.553515e-01 0.809 0 0
Diseases of Immune System R-HSA-5260271 1.553515e-01 0.809 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.359481e-01 0.361 0 0
Metabolism of serotonin R-HSA-380612 4.359481e-01 0.361 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.359481e-01 0.361 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.333727e-01 0.477 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.707028e-01 0.568 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.063291e-01 0.514 0 0
TCR signaling R-HSA-202403 1.742033e-01 0.759 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.961127e-01 0.402 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.264667e-01 0.370 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.537715e-01 0.596 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.613002e-01 0.442 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.129805e-01 0.384 0 0
Ca2+ pathway R-HSA-4086398 2.869311e-01 0.542 0 0
Interleukin-9 signaling R-HSA-8985947 3.839858e-01 0.416 0 0
Interleukin-1 signaling R-HSA-9020702 2.272960e-01 0.643 0 0
Signaling by NOTCH R-HSA-157118 3.606138e-01 0.443 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.421188e-01 0.466 0 0
Gene expression (Transcription) R-HSA-74160 2.485340e-01 0.605 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.839858e-01 0.416 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.538736e-01 0.451 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.810492e-01 0.419 0 0
HCMV Infection R-HSA-9609646 1.457249e-01 0.836 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.011829e-01 0.696 0 0
EPH-Ephrin signaling R-HSA-2682334 1.671799e-01 0.777 0 0
Generic Transcription Pathway R-HSA-212436 4.310650e-01 0.365 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.321982e-01 0.634 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.884811e-01 0.725 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.562388e-01 0.448 0 0
Interleukin-21 signaling R-HSA-9020958 4.105384e-01 0.387 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.359481e-01 0.361 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.589235e-01 0.587 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.492716e-01 0.457 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.182570e-01 0.497 0 0
Metabolism of RNA R-HSA-8953854 3.723160e-01 0.429 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.207994e-01 0.376 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.338370e-01 0.363 0 0
PLC beta mediated events R-HSA-112043 1.908108e-01 0.719 1 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.851036e-01 0.545 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.163844e-01 0.665 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.492716e-01 0.457 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.963218e-01 0.707 0 0
Other interleukin signaling R-HSA-449836 2.851036e-01 0.545 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.209260e-01 0.656 0 0
Signaling by Hedgehog R-HSA-5358351 2.476080e-01 0.606 0 0
IRS activation R-HSA-74713 2.652834e-01 0.576 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.969449e-01 0.527 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.884811e-01 0.725 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.043677e-01 0.690 0 0
Phase 2 - plateau phase R-HSA-5576893 2.365160e-01 0.626 0 0
Nucleotide salvage defects R-HSA-9734207 3.839858e-01 0.416 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.839858e-01 0.416 0 0
Specification of the neural plate border R-HSA-9834899 2.851036e-01 0.545 0 0
ARMS-mediated activation R-HSA-170984 4.105384e-01 0.387 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.487281e-01 0.458 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.487281e-01 0.458 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.487281e-01 0.458 0 0
DAG and IP3 signaling R-HSA-1489509 2.072802e-01 0.683 1 0
Insulin receptor signalling cascade R-HSA-74751 3.909012e-01 0.408 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.106813e-01 0.386 0 0
Interleukin-1 family signaling R-HSA-446652 3.355885e-01 0.474 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.552033e-01 0.809 0 0
Interleukin-6 signaling R-HSA-1059683 1.727781e-01 0.763 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.806589e-01 0.419 0 0
G-protein mediated events R-HSA-112040 2.375093e-01 0.624 1 0
Receptor Mediated Mitophagy R-HSA-8934903 4.359481e-01 0.361 0 0
Nuclear import of Rev protein R-HSA-180746 2.707028e-01 0.568 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.825391e-01 0.549 0 0
Triglyceride biosynthesis R-HSA-75109 4.264667e-01 0.370 0 0
TBC/RABGAPs R-HSA-8854214 3.895589e-01 0.409 0 0
Toll-like Receptor Cascades R-HSA-168898 3.229561e-01 0.491 0 0
Mitochondrial biogenesis R-HSA-1592230 2.240536e-01 0.650 0 0
Developmental Biology R-HSA-1266738 2.144337e-01 0.669 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.689047e-01 0.570 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.129805e-01 0.384 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.129805e-01 0.384 0 0
S Phase R-HSA-69242 3.114816e-01 0.507 0 0
ER-Phagosome pathway R-HSA-1236974 4.326156e-01 0.364 0 0
Platelet degranulation R-HSA-114608 4.343025e-01 0.362 0 0
Signaling by FGFR in disease R-HSA-1226099 2.953571e-01 0.530 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.727781e-01 0.763 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.203931e-01 0.657 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.562388e-01 0.448 0 0
TGFBR3 expression R-HSA-9839394 1.579396e-01 0.802 0 0
Adrenoceptors R-HSA-390696 3.839858e-01 0.416 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.839858e-01 0.416 0 0
RSK activation R-HSA-444257 3.839858e-01 0.416 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.105384e-01 0.387 0 0
Interleukin-27 signaling R-HSA-9020956 4.359481e-01 0.361 0 0
RET signaling R-HSA-8853659 2.944189e-01 0.531 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.421188e-01 0.466 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.421188e-01 0.466 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.540298e-01 0.451 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.810492e-01 0.419 0 0
G1/S Transition R-HSA-69206 2.783834e-01 0.555 0 0
Signaling by Interleukins R-HSA-449147 2.151990e-01 0.667 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.264667e-01 0.370 0 0
Netrin-1 signaling R-HSA-373752 1.982907e-01 0.703 0 0
Signaling by SCF-KIT R-HSA-1433557 1.894241e-01 0.723 0 0
Co-inhibition by PD-1 R-HSA-389948 1.743968e-01 0.758 0 0
Pyruvate metabolism R-HSA-70268 4.155094e-01 0.381 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.105384e-01 0.387 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.552174e-01 0.450 0 0
Signaling by TGFBR3 R-HSA-9839373 2.163844e-01 0.665 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.707028e-01 0.568 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.063291e-01 0.514 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.514154e-01 0.454 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.652834e-01 0.576 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.969449e-01 0.527 0 0
Nef and signal transduction R-HSA-164944 3.272438e-01 0.485 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.043677e-01 0.690 0 0
Interleukin-1 processing R-HSA-448706 4.105384e-01 0.387 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.012653e-01 0.521 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.492716e-01 0.457 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.650398e-01 0.438 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.182570e-01 0.497 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.245863e-01 0.372 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.010185e-01 0.521 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.283420e-01 0.484 0 0
CREB3 factors activate genes R-HSA-8874211 3.272438e-01 0.485 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.961127e-01 0.402 0 0
Signal transduction by L1 R-HSA-445144 3.012653e-01 0.521 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.619474e-01 0.582 0 0
Interleukin-6 family signaling R-HSA-6783589 3.806589e-01 0.419 0 0
Ion transport by P-type ATPases R-HSA-936837 3.909012e-01 0.408 0 0
Glycolysis R-HSA-70171 3.641905e-01 0.439 0 0
Cellular response to heat stress R-HSA-3371556 1.461482e-01 0.835 0 0
TNF signaling R-HSA-75893 3.119574e-01 0.506 0 0
Inositol phosphate metabolism R-HSA-1483249 3.073007e-01 0.512 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.969449e-01 0.527 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.969449e-01 0.527 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.727781e-01 0.763 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.203931e-01 0.657 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.333727e-01 0.477 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.301908e-01 0.481 0 0
Signaling by ROBO receptors R-HSA-376176 2.769336e-01 0.558 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.995748e-01 0.523 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.785509e-01 0.555 0 0
Formation of definitive endoderm R-HSA-9823730 3.012653e-01 0.521 0 0
Signaling by KIT in disease R-HSA-9669938 3.492716e-01 0.457 0 0
Diseases of DNA repair R-HSA-9675135 4.245863e-01 0.372 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.245863e-01 0.372 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.652834e-01 0.576 0 0
Signal attenuation R-HSA-74749 4.359481e-01 0.361 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.333727e-01 0.477 0 0
TRP channels R-HSA-3295583 4.113863e-01 0.386 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.536222e-01 0.814 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 3.650398e-01 0.438 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.895589e-01 0.409 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.652834e-01 0.576 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.793022e-01 0.746 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.689047e-01 0.570 0 0
Assembly Of The HIV Virion R-HSA-175474 3.333727e-01 0.477 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.113863e-01 0.386 0 0
Death Receptor Signaling R-HSA-73887 2.311139e-01 0.636 0 0
FOXO-mediated transcription R-HSA-9614085 3.564535e-01 0.448 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.173632e-01 0.498 0 0
Specification of primordial germ cells R-HSA-9827857 2.526982e-01 0.597 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.851036e-01 0.545 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.727781e-01 0.763 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.105384e-01 0.387 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.113863e-01 0.386 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.689047e-01 0.570 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.806589e-01 0.419 0 0
Neurodegenerative Diseases R-HSA-8863678 3.806589e-01 0.419 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.013903e-01 0.696 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.147049e-01 0.668 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.119574e-01 0.506 0 0
Regulation of beta-cell development R-HSA-186712 1.760355e-01 0.754 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.359481e-01 0.361 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.507877e-01 0.822 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.650398e-01 0.438 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.361116e-01 0.360 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.411299e-01 0.355 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.413420e-01 0.355 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.413420e-01 0.355 0 0
HIV elongation arrest and recovery R-HSA-167287 4.413420e-01 0.355 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.413420e-01 0.355 0 0
Telomere Extension By Telomerase R-HSA-171319 4.413420e-01 0.355 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.413420e-01 0.355 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.415236e-01 0.355 0 0
RNA Polymerase II Transcription R-HSA-73857 4.458051e-01 0.351 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.491896e-01 0.348 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.491896e-01 0.348 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.493482e-01 0.347 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.493482e-01 0.347 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.496137e-01 0.347 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.496137e-01 0.347 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.560020e-01 0.341 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.560020e-01 0.341 0 0
Late endosomal microautophagy R-HSA-9615710 4.560020e-01 0.341 0 0
DARPP-32 events R-HSA-180024 4.560020e-01 0.341 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.580637e-01 0.339 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.587820e-01 0.338 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.588928e-01 0.338 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.588928e-01 0.338 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.598527e-01 0.337 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.602639e-01 0.337 0 0
Interleukin-2 signaling R-HSA-9020558 4.602639e-01 0.337 0 0
vRNP Assembly R-HSA-192905 4.602639e-01 0.337 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.602639e-01 0.337 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.602639e-01 0.337 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.605140e-01 0.337 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.644503e-01 0.333 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.644503e-01 0.333 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.664768e-01 0.331 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.684567e-01 0.329 0 0
PI3K Cascade R-HSA-109704 4.701357e-01 0.328 0 0
Activation of the pre-replicative complex R-HSA-68962 4.704376e-01 0.327 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.704376e-01 0.327 0 0
Interleukin-37 signaling R-HSA-9008059 4.704376e-01 0.327 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.720399e-01 0.326 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.748497e-01 0.323 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.779204e-01 0.321 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.795993e-01 0.319 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.831795e-01 0.316 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.833626e-01 0.316 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.835329e-01 0.316 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.835329e-01 0.316 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.835329e-01 0.316 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.835329e-01 0.316 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.835329e-01 0.316 0 0
NF-kB is activated and signals survival R-HSA-209560 4.835329e-01 0.316 0 0
ERKs are inactivated R-HSA-202670 4.835329e-01 0.316 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.835329e-01 0.316 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.835329e-01 0.316 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.835329e-01 0.316 0 0
Integration of provirus R-HSA-162592 4.835329e-01 0.316 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.846410e-01 0.315 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.846410e-01 0.315 0 0
Budding and maturation of HIV virion R-HSA-162588 4.846410e-01 0.315 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.846410e-01 0.315 0 0
Signaling by ERBB4 R-HSA-1236394 4.873185e-01 0.312 0 0
Signaling by NOTCH4 R-HSA-9013694 4.873185e-01 0.312 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.914632e-01 0.309 0 0
Orc1 removal from chromatin R-HSA-68949 4.922965e-01 0.308 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.922965e-01 0.308 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.922965e-01 0.308 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.922965e-01 0.308 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.946181e-01 0.306 0 0
Protein ubiquitination R-HSA-8852135 4.966471e-01 0.304 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.986053e-01 0.302 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.986053e-01 0.302 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.996982e-01 0.301 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.996982e-01 0.301 0 0
Cellular response to chemical stress R-HSA-9711123 5.020527e-01 0.299 0 0
Meiotic synapsis R-HSA-1221632 5.032039e-01 0.298 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.032039e-01 0.298 0 0
HIV Life Cycle R-HSA-162587 5.057285e-01 0.296 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.058001e-01 0.296 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.058001e-01 0.296 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.058001e-01 0.296 0 0
Regulation of IFNG signaling R-HSA-877312 5.058001e-01 0.296 0 0
Interleukin-35 Signalling R-HSA-8984722 5.058001e-01 0.296 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.058001e-01 0.296 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.058001e-01 0.296 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.058001e-01 0.296 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.058001e-01 0.296 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.058001e-01 0.296 0 0
OAS antiviral response R-HSA-8983711 5.058001e-01 0.296 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.058001e-01 0.296 0 0
Signaling by LTK R-HSA-9842663 5.058001e-01 0.296 0 0
Signaling by NOTCH1 R-HSA-1980143 5.059027e-01 0.296 0 0
UCH proteinases R-HSA-5689603 5.059027e-01 0.296 0 0
DNA Repair R-HSA-73894 5.070296e-01 0.295 0 0
Influenza Infection R-HSA-168255 5.072227e-01 0.295 0 0
Integration of energy metabolism R-HSA-163685 5.108700e-01 0.292 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.123234e-01 0.290 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.123248e-01 0.290 0 0
Nuclear RNA decay R-HSA-9930044 5.123248e-01 0.290 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.123248e-01 0.290 0 0
Translation initiation complex formation R-HSA-72649 5.139896e-01 0.289 0 0
Glucose metabolism R-HSA-70326 5.168643e-01 0.287 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.241813e-01 0.281 0 0
HDACs deacetylate histones R-HSA-3214815 5.246493e-01 0.280 0 0
Acyl chain remodelling of PC R-HSA-1482788 5.257946e-01 0.279 0 0
HIV Infection R-HSA-162906 5.259455e-01 0.279 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.271086e-01 0.278 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.271086e-01 0.278 0 0
Frs2-mediated activation R-HSA-170968 5.271086e-01 0.278 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.271086e-01 0.278 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.271086e-01 0.278 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.271086e-01 0.278 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.271086e-01 0.278 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.271086e-01 0.278 0 0
Maturation of nucleoprotein R-HSA-9683610 5.271086e-01 0.278 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.271086e-01 0.278 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.351790e-01 0.272 0 0
Ion homeostasis R-HSA-5578775 5.351790e-01 0.272 0 0
Signal amplification R-HSA-392518 5.390107e-01 0.268 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.390107e-01 0.268 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.455752e-01 0.263 0 0
Regulation of CDH1 Function R-HSA-9764561 5.455752e-01 0.263 0 0
IRS-mediated signalling R-HSA-112399 5.455752e-01 0.263 0 0
Synthesis of PA R-HSA-1483166 5.455752e-01 0.263 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.474995e-01 0.262 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.474995e-01 0.262 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.474995e-01 0.262 0 0
Hydrolysis of LPC R-HSA-1483115 5.474995e-01 0.262 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.474995e-01 0.262 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.474995e-01 0.262 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.474995e-01 0.262 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.509721e-01 0.259 0 0
Cell junction organization R-HSA-446728 5.512383e-01 0.259 0 0
Regulation of Apoptosis R-HSA-169911 5.519700e-01 0.258 0 0
Acyl chain remodelling of PE R-HSA-1482839 5.519700e-01 0.258 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.519700e-01 0.258 0 0
rRNA processing R-HSA-72312 5.524635e-01 0.258 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.558345e-01 0.255 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.558345e-01 0.255 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.560669e-01 0.255 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.576931e-01 0.254 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.597243e-01 0.252 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.646701e-01 0.248 0 0
GPVI-mediated activation cascade R-HSA-114604 5.646701e-01 0.248 0 0
Metabolism of non-coding RNA R-HSA-194441 5.659541e-01 0.247 0 0
snRNP Assembly R-HSA-191859 5.659541e-01 0.247 0 0
Triglyceride metabolism R-HSA-8979227 5.659541e-01 0.247 0 0
Ion channel transport R-HSA-983712 5.659550e-01 0.247 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.670124e-01 0.246 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.670124e-01 0.246 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.670124e-01 0.246 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.670124e-01 0.246 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 5.670124e-01 0.246 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.670124e-01 0.246 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.670124e-01 0.246 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.670124e-01 0.246 0 0
p75NTR signals via NF-kB R-HSA-193639 5.670124e-01 0.246 0 0
Other semaphorin interactions R-HSA-416700 5.670124e-01 0.246 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.670124e-01 0.246 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.670124e-01 0.246 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.670124e-01 0.246 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.670124e-01 0.246 0 0
Formation of the anterior neural plate R-HSA-9823739 5.670124e-01 0.246 0 0
Host Interactions of HIV factors R-HSA-162909 5.671853e-01 0.246 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.751149e-01 0.240 0 0
RSV-host interactions R-HSA-9833110 5.788275e-01 0.237 0 0
Meiosis R-HSA-1500620 5.854139e-01 0.233 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.854139e-01 0.233 0 0
Phosphorylation of the APC/C R-HSA-176412 5.856849e-01 0.232 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.856849e-01 0.232 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.856849e-01 0.232 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.856849e-01 0.232 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.856849e-01 0.232 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.856849e-01 0.232 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.856849e-01 0.232 0 0
Prolonged ERK activation events R-HSA-169893 5.856849e-01 0.232 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.856849e-01 0.232 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.856849e-01 0.232 0 0
Differentiation of T cells R-HSA-9945266 5.856849e-01 0.232 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.856849e-01 0.232 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.857636e-01 0.232 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.857636e-01 0.232 0 0
Platelet homeostasis R-HSA-418346 5.938433e-01 0.226 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.954491e-01 0.225 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.954491e-01 0.225 0 0
Heme signaling R-HSA-9707616 5.954491e-01 0.225 0 0
Mitochondrial protein import R-HSA-1268020 5.954491e-01 0.225 0 0
tRNA processing in the nucleus R-HSA-6784531 5.954491e-01 0.225 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.012006e-01 0.221 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 6.012006e-01 0.221 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.012006e-01 0.221 0 0
Adherens junctions interactions R-HSA-418990 6.016836e-01 0.221 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.035533e-01 0.219 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.035533e-01 0.219 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.035533e-01 0.219 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.035533e-01 0.219 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 6.035533e-01 0.219 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.035533e-01 0.219 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.035533e-01 0.219 0 0
Synthesis of PG R-HSA-1483148 6.035533e-01 0.219 0 0
Galactose catabolism R-HSA-70370 6.035533e-01 0.219 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.035533e-01 0.219 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.049861e-01 0.218 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.085577e-01 0.216 0 0
Stimuli-sensing channels R-HSA-2672351 6.085577e-01 0.216 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.095093e-01 0.215 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.095093e-01 0.215 0 0
Viral Infection Pathways R-HSA-9824446 6.100093e-01 0.215 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.128524e-01 0.213 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.128524e-01 0.213 0 0
HIV Transcription Elongation R-HSA-167169 6.128524e-01 0.213 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.128524e-01 0.213 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.128524e-01 0.213 0 0
Glycogen metabolism R-HSA-8982491 6.128524e-01 0.213 0 0
IGF1R signaling cascade R-HSA-2428924 6.143729e-01 0.212 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.152635e-01 0.211 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.157986e-01 0.211 0 0
Peptide chain elongation R-HSA-156902 6.182728e-01 0.209 0 0
Diseases of programmed cell death R-HSA-9645723 6.182728e-01 0.209 0 0
Cell-Cell communication R-HSA-1500931 6.186597e-01 0.209 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.206521e-01 0.207 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.206521e-01 0.207 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.206521e-01 0.207 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.206521e-01 0.207 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.206521e-01 0.207 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.206521e-01 0.207 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.206521e-01 0.207 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 6.206521e-01 0.207 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.206521e-01 0.207 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.206521e-01 0.207 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.206521e-01 0.207 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.206521e-01 0.207 0 0
Reproduction R-HSA-1474165 6.214039e-01 0.207 0 0
Cellular response to hypoxia R-HSA-1234174 6.236083e-01 0.205 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.236083e-01 0.205 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.242420e-01 0.205 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.242420e-01 0.205 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.353704e-01 0.197 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.353704e-01 0.197 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.370145e-01 0.196 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.370145e-01 0.196 0 0
Polo-like kinase mediated events R-HSA-156711 6.370145e-01 0.196 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.370145e-01 0.196 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.370145e-01 0.196 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.370145e-01 0.196 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.416210e-01 0.193 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.426697e-01 0.192 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.439601e-01 0.191 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.462390e-01 0.190 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 6.462390e-01 0.190 0 0
Innate Immune System R-HSA-168249 6.488861e-01 0.188 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.503969e-01 0.187 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.526720e-01 0.185 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.526720e-01 0.185 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.526720e-01 0.185 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.526720e-01 0.185 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.526720e-01 0.185 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.526720e-01 0.185 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.526720e-01 0.185 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.526720e-01 0.185 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.526720e-01 0.185 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 6.526720e-01 0.185 0 0
Rap1 signalling R-HSA-392517 6.526720e-01 0.185 0 0
Maturation of nucleoprotein R-HSA-9694631 6.526720e-01 0.185 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.526720e-01 0.185 0 0
The NLRP3 inflammasome R-HSA-844456 6.526720e-01 0.185 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.526720e-01 0.185 0 0
Signaling by Insulin receptor R-HSA-74752 6.569790e-01 0.182 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.672037e-01 0.176 0 0
Amine ligand-binding receptors R-HSA-375280 6.672037e-01 0.176 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.676551e-01 0.175 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.676551e-01 0.175 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.676551e-01 0.175 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.676551e-01 0.175 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.676551e-01 0.175 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.676551e-01 0.175 0 0
Keratan sulfate degradation R-HSA-2022857 6.676551e-01 0.175 0 0
Negative regulation of MET activity R-HSA-6807004 6.676551e-01 0.175 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.676551e-01 0.175 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.676551e-01 0.175 0 0
Pregnenolone biosynthesis R-HSA-196108 6.676551e-01 0.175 0 0
Nephrin family interactions R-HSA-373753 6.676551e-01 0.175 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.715422e-01 0.173 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.757984e-01 0.170 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.757984e-01 0.170 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.773042e-01 0.169 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.773042e-01 0.169 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.773042e-01 0.169 0 0
Ribosome-associated quality control R-HSA-9948299 6.775024e-01 0.169 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.788964e-01 0.168 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.819927e-01 0.166 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.819927e-01 0.166 0 0
G-protein activation R-HSA-202040 6.819927e-01 0.166 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.819927e-01 0.166 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.819927e-01 0.166 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.819927e-01 0.166 0 0
ERK/MAPK targets R-HSA-198753 6.819927e-01 0.166 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.819927e-01 0.166 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.819927e-01 0.166 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.819927e-01 0.166 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.839567e-01 0.165 0 0
Eukaryotic Translation Termination R-HSA-72764 6.859814e-01 0.164 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.871535e-01 0.163 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.871535e-01 0.163 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.919610e-01 0.160 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.949610e-01 0.158 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.957125e-01 0.158 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.957125e-01 0.158 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.967546e-01 0.157 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.065709e-01 0.151 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.075095e-01 0.150 0 0
FGFR2 alternative splicing R-HSA-6803529 7.088413e-01 0.149 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.088413e-01 0.149 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.088413e-01 0.149 0 0
Fructose metabolism R-HSA-5652084 7.088413e-01 0.149 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.088413e-01 0.149 0 0
Ethanol oxidation R-HSA-71384 7.088413e-01 0.149 0 0
HATs acetylate histones R-HSA-3214847 7.132122e-01 0.147 0 0
Degradation of CDH1 R-HSA-9766229 7.152244e-01 0.146 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.214044e-01 0.142 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.214044e-01 0.142 0 0
Interleukin-20 family signaling R-HSA-8854691 7.214044e-01 0.142 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 7.214044e-01 0.142 0 0
Organic anion transport by SLCO transporters R-HSA-879518 7.214044e-01 0.142 0 0
Carnitine shuttle R-HSA-200425 7.214044e-01 0.142 0 0
Growth hormone receptor signaling R-HSA-982772 7.214044e-01 0.142 0 0
Formation of the ureteric bud R-HSA-9830674 7.214044e-01 0.142 0 0
Syndecan interactions R-HSA-3000170 7.214044e-01 0.142 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.240998e-01 0.140 0 0
Selenocysteine synthesis R-HSA-2408557 7.261631e-01 0.139 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.295555e-01 0.137 0 0
Integrin cell surface interactions R-HSA-216083 7.296931e-01 0.137 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.324732e-01 0.135 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.327404e-01 0.135 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.327404e-01 0.135 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.334261e-01 0.135 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.334261e-01 0.135 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.334261e-01 0.135 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.334261e-01 0.135 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.334261e-01 0.135 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.334261e-01 0.135 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.334261e-01 0.135 0 0
Sensory processing of sound R-HSA-9659379 7.367877e-01 0.133 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.367877e-01 0.133 0 0
Viral mRNA Translation R-HSA-192823 7.386736e-01 0.132 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.411498e-01 0.130 0 0
mRNA 3'-end processing R-HSA-72187 7.411498e-01 0.130 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.411498e-01 0.130 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.437342e-01 0.129 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.447647e-01 0.128 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.449298e-01 0.128 0 0
G protein gated Potassium channels R-HSA-1296059 7.449298e-01 0.128 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.449298e-01 0.128 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.449298e-01 0.128 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.449298e-01 0.128 0 0
Hyaluronan degradation R-HSA-2160916 7.449298e-01 0.128 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.449298e-01 0.128 0 0
Formation of the nephric duct R-HSA-9830364 7.449298e-01 0.128 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.449298e-01 0.128 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.493319e-01 0.125 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.493319e-01 0.125 0 0
Cell-cell junction organization R-HSA-421270 7.538165e-01 0.123 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.547006e-01 0.122 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.559377e-01 0.122 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.559377e-01 0.122 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.559377e-01 0.122 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.559377e-01 0.122 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.559377e-01 0.122 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.559377e-01 0.122 0 0
Urea cycle R-HSA-70635 7.559377e-01 0.122 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.559377e-01 0.122 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.572906e-01 0.121 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.583614e-01 0.120 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.583614e-01 0.120 0 0
DNA Replication R-HSA-69306 7.631785e-01 0.117 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.636987e-01 0.117 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.664712e-01 0.116 0 0
Packaging Of Telomere Ends R-HSA-171306 7.664712e-01 0.116 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.664712e-01 0.116 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.664712e-01 0.116 0 0
Synthesis of PE R-HSA-1483213 7.664712e-01 0.116 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.664712e-01 0.116 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.680485e-01 0.115 0 0
Synthesis of DNA R-HSA-69239 7.680485e-01 0.115 0 0
Deubiquitination R-HSA-5688426 7.691902e-01 0.114 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.700667e-01 0.113 0 0
Parasitic Infection Pathways R-HSA-9824443 7.718685e-01 0.112 0 0
Leishmania infection R-HSA-9658195 7.718685e-01 0.112 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.725543e-01 0.112 0 0
Signaling by FGFR1 R-HSA-5654736 7.725543e-01 0.112 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.725543e-01 0.112 0 0
Cardiac conduction R-HSA-5576891 7.744915e-01 0.111 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.765507e-01 0.110 0 0
Pyroptosis R-HSA-5620971 7.765507e-01 0.110 0 0
Inflammasomes R-HSA-622312 7.765507e-01 0.110 0 0
SARS-CoV Infections R-HSA-9679506 7.789765e-01 0.108 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.823821e-01 0.107 0 0
mRNA Capping R-HSA-72086 7.861957e-01 0.104 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.861957e-01 0.104 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.861957e-01 0.104 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 7.861957e-01 0.104 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.861957e-01 0.104 0 0
Platelet calcium homeostasis R-HSA-418360 7.861957e-01 0.104 0 0
Glucagon-type ligand receptors R-HSA-420092 7.861957e-01 0.104 0 0
Signaling by Erythropoietin R-HSA-9006335 7.861957e-01 0.104 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.861957e-01 0.104 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.862021e-01 0.104 0 0
Cellular response to starvation R-HSA-9711097 7.862021e-01 0.104 0 0
Extension of Telomeres R-HSA-180786 7.938773e-01 0.100 0 0
Peroxisomal protein import R-HSA-9033241 7.938773e-01 0.100 0 0
Signaling by TGFB family members R-HSA-9006936 7.949215e-01 0.100 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.954250e-01 0.099 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.954250e-01 0.099 0 0
DAP12 signaling R-HSA-2424491 7.954250e-01 0.099 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.954250e-01 0.099 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.954250e-01 0.099 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.954250e-01 0.099 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.954250e-01 0.099 0 0
Neurotransmitter clearance R-HSA-112311 7.954250e-01 0.099 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.042564e-01 0.095 0 0
Cargo concentration in the ER R-HSA-5694530 8.042564e-01 0.095 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.042564e-01 0.095 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.042564e-01 0.095 0 0
Downstream signal transduction R-HSA-186763 8.042564e-01 0.095 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.070935e-01 0.093 0 0
MAP kinase activation R-HSA-450294 8.070935e-01 0.093 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.095903e-01 0.092 0 0
Downstream TCR signaling R-HSA-202424 8.107986e-01 0.091 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.127071e-01 0.090 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.127071e-01 0.090 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.127071e-01 0.090 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.134146e-01 0.090 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.134146e-01 0.090 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.199573e-01 0.086 0 0
Leishmania phagocytosis R-HSA-9664417 8.202306e-01 0.086 0 0
Parasite infection R-HSA-9664407 8.202306e-01 0.086 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.202306e-01 0.086 0 0
Keratan sulfate biosynthesis R-HSA-2022854 8.207934e-01 0.086 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.207934e-01 0.086 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.207934e-01 0.086 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.207934e-01 0.086 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.207934e-01 0.086 0 0
Cardiogenesis R-HSA-9733709 8.207934e-01 0.086 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.207934e-01 0.086 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.255041e-01 0.083 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.273255e-01 0.082 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.285311e-01 0.082 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.285311e-01 0.082 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.285311e-01 0.082 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.285311e-01 0.082 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.285311e-01 0.082 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.285311e-01 0.082 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.285311e-01 0.082 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.285311e-01 0.082 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.285311e-01 0.082 0 0
Dual Incision in GG-NER R-HSA-5696400 8.359352e-01 0.078 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.359352e-01 0.078 0 0
eNOS activation R-HSA-203615 8.359352e-01 0.078 0 0
Hyaluronan metabolism R-HSA-2142845 8.359352e-01 0.078 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.359352e-01 0.078 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.359352e-01 0.078 0 0
Mitophagy R-HSA-5205647 8.359352e-01 0.078 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.359352e-01 0.078 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.359352e-01 0.078 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.359352e-01 0.078 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.359352e-01 0.078 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.359352e-01 0.078 0 0
Mitochondrial protein degradation R-HSA-9837999 8.360152e-01 0.078 0 0
Kidney development R-HSA-9830369 8.423198e-01 0.075 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.430199e-01 0.074 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.430199e-01 0.074 0 0
Signalling to ERKs R-HSA-187687 8.430199e-01 0.074 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 8.430199e-01 0.074 0 0
Transcription of the HIV genome R-HSA-167172 8.475901e-01 0.072 0 0
Potassium Channels R-HSA-1296071 8.497129e-01 0.071 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.497992e-01 0.071 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.497992e-01 0.071 0 0
FLT3 signaling in disease R-HSA-9682385 8.497992e-01 0.071 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.497992e-01 0.071 0 0
Triglyceride catabolism R-HSA-163560 8.497992e-01 0.071 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.497992e-01 0.071 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.497992e-01 0.071 0 0
Telomere Maintenance R-HSA-157579 8.540524e-01 0.069 0 0
Voltage gated Potassium channels R-HSA-1296072 8.562860e-01 0.067 0 0
Degradation of AXIN R-HSA-4641257 8.562860e-01 0.067 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.562860e-01 0.067 0 0
Cleavage of the damaged purine R-HSA-110331 8.562860e-01 0.067 0 0
Interleukin-17 signaling R-HSA-448424 8.576528e-01 0.067 0 0
Signaling by FGFR R-HSA-190236 8.582821e-01 0.066 0 0
Potential therapeutics for SARS R-HSA-9679191 8.615957e-01 0.065 0 0
Hedgehog 'on' state R-HSA-5632684 8.624533e-01 0.064 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.624931e-01 0.064 0 0
Depurination R-HSA-73927 8.624931e-01 0.064 0 0
Purine salvage R-HSA-74217 8.624931e-01 0.064 0 0
Elastic fibre formation R-HSA-1566948 8.624931e-01 0.064 0 0
mRNA Splicing R-HSA-72172 8.627445e-01 0.064 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.671050e-01 0.062 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.684325e-01 0.061 0 0
Pentose phosphate pathway R-HSA-71336 8.684325e-01 0.061 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.684325e-01 0.061 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.684325e-01 0.061 0 0
Protein localization R-HSA-9609507 8.713881e-01 0.060 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.741157e-01 0.058 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.741157e-01 0.058 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.741157e-01 0.058 0 0
Attenuation phase R-HSA-3371568 8.741157e-01 0.058 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.741157e-01 0.058 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.759779e-01 0.058 0 0
PPARA activates gene expression R-HSA-1989781 8.775857e-01 0.057 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.795537e-01 0.056 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.795537e-01 0.056 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.795537e-01 0.056 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.795537e-01 0.056 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.802067e-01 0.055 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.802067e-01 0.055 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.835277e-01 0.054 0 0
HCMV Late Events R-HSA-9610379 8.835277e-01 0.054 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.847571e-01 0.053 0 0
HIV Transcription Initiation R-HSA-167161 8.847571e-01 0.053 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.847571e-01 0.053 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.847571e-01 0.053 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.847571e-01 0.053 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.847571e-01 0.053 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.847571e-01 0.053 0 0
Heme biosynthesis R-HSA-189451 8.847571e-01 0.053 0 0
Translation of Structural Proteins R-HSA-9683701 8.847571e-01 0.053 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.849896e-01 0.053 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.849896e-01 0.053 0 0
Hemostasis R-HSA-109582 8.868672e-01 0.052 0 0
Nucleotide Excision Repair R-HSA-5696398 8.884149e-01 0.051 0 0
Activation of GABAB receptors R-HSA-991365 8.897360e-01 0.051 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.897360e-01 0.051 0 0
GABA B receptor activation R-HSA-977444 8.897360e-01 0.051 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.897360e-01 0.051 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.897360e-01 0.051 0 0
Depyrimidination R-HSA-73928 8.897360e-01 0.051 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.917489e-01 0.050 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.945001e-01 0.048 0 0
Defective pyroptosis R-HSA-9710421 8.945001e-01 0.048 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.945001e-01 0.048 0 0
Signaling by FGFR4 R-HSA-5654743 8.945001e-01 0.048 0 0
Gene Silencing by RNA R-HSA-211000 8.949932e-01 0.048 0 0
DAP12 interactions R-HSA-2172127 8.990587e-01 0.046 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.990587e-01 0.046 0 0
Proteasome assembly R-HSA-9907900 8.990587e-01 0.046 0 0
G1 Phase R-HSA-69236 8.990587e-01 0.046 0 0
Cyclin D associated events in G1 R-HSA-69231 8.990587e-01 0.046 0 0
Signaling by FGFR2 R-HSA-5654738 8.994194e-01 0.046 0 0
Selenoamino acid metabolism R-HSA-2408522 9.024185e-01 0.045 0 0
Post-translational protein modification R-HSA-597592 9.028576e-01 0.044 0 0
Amyloid fiber formation R-HSA-977225 9.029002e-01 0.044 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.034205e-01 0.044 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.034205e-01 0.044 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.034205e-01 0.044 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.034205e-01 0.044 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.034205e-01 0.044 0 0
Signaling by FGFR3 R-HSA-5654741 9.034205e-01 0.044 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.075941e-01 0.042 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.075941e-01 0.042 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.075941e-01 0.042 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.075941e-01 0.042 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.095271e-01 0.041 0 0
SLC transporter disorders R-HSA-5619102 9.096629e-01 0.041 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.099399e-01 0.041 0 0
Synthesis of PC R-HSA-1483191 9.115876e-01 0.040 0 0
GPER1 signaling R-HSA-9634597 9.154088e-01 0.038 0 0
NGF-stimulated transcription R-HSA-9031628 9.154088e-01 0.038 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.190650e-01 0.037 0 0
DNA Damage Bypass R-HSA-73893 9.190650e-01 0.037 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.190650e-01 0.037 0 0
Disease R-HSA-1643685 9.197266e-01 0.036 0 0
Azathioprine ADME R-HSA-9748787 9.225634e-01 0.035 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.225634e-01 0.035 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.229311e-01 0.035 0 0
Ub-specific processing proteases R-HSA-5689880 9.247619e-01 0.034 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.252791e-01 0.034 0 0
Meiotic recombination R-HSA-912446 9.259108e-01 0.033 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.259108e-01 0.033 0 0
The phototransduction cascade R-HSA-2514856 9.259108e-01 0.033 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.286440e-01 0.032 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.291137e-01 0.032 0 0
Base Excision Repair R-HSA-73884 9.320211e-01 0.031 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.320211e-01 0.031 0 0
Signaling by NTRKs R-HSA-166520 9.339476e-01 0.030 0 0
GPCR downstream signalling R-HSA-388396 9.344657e-01 0.029 1 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.351106e-01 0.029 0 0
Chromosome Maintenance R-HSA-73886 9.362477e-01 0.029 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.362477e-01 0.029 0 0
G alpha (z) signalling events R-HSA-418597 9.379163e-01 0.028 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.406008e-01 0.027 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.406008e-01 0.027 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.411762e-01 0.026 0 0
Formation of the cornified envelope R-HSA-6809371 9.420786e-01 0.026 0 0
Dectin-2 family R-HSA-5621480 9.431694e-01 0.025 0 0
Infectious disease R-HSA-5663205 9.446385e-01 0.025 0 0
Dual incision in TC-NER R-HSA-6782135 9.456271e-01 0.024 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.456271e-01 0.024 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.491520e-01 0.023 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.502286e-01 0.022 0 0
GABA receptor activation R-HSA-977443 9.502286e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.502286e-01 0.022 0 0
Metabolism of polyamines R-HSA-351202 9.502286e-01 0.022 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.502286e-01 0.022 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.507099e-01 0.022 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.509787e-01 0.022 0 0
Aquaporin-mediated transport R-HSA-445717 9.523814e-01 0.021 0 0
Nucleotide salvage R-HSA-8956321 9.523814e-01 0.021 0 0
Signaling by PDGF R-HSA-186797 9.544413e-01 0.020 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.544413e-01 0.020 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.592102e-01 0.018 0 0
PI Metabolism R-HSA-1483255 9.592102e-01 0.018 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.606895e-01 0.017 0 0
Nicotinate metabolism R-HSA-196807 9.634799e-01 0.016 0 0
Metabolism of steroid hormones R-HSA-196071 9.634799e-01 0.016 0 0
Regulated Necrosis R-HSA-5218859 9.650602e-01 0.015 0 0
G alpha (q) signalling events R-HSA-416476 9.666434e-01 0.015 0 0
Phospholipid metabolism R-HSA-1483257 9.672721e-01 0.014 0 0
G alpha (s) signalling events R-HSA-418555 9.676826e-01 0.014 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.680189e-01 0.014 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.680189e-01 0.014 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.694031e-01 0.013 0 0
ECM proteoglycans R-HSA-3000178 9.694031e-01 0.013 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.694031e-01 0.013 0 0
Metabolism of cofactors R-HSA-8978934 9.694031e-01 0.013 0 0
Metabolism of porphyrins R-HSA-189445 9.694031e-01 0.013 0 0
Signaling by GPCR R-HSA-372790 9.722683e-01 0.012 1 0
FCERI mediated NF-kB activation R-HSA-2871837 9.737153e-01 0.012 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.754764e-01 0.011 0 0
Translation of Structural Proteins R-HSA-9694635 9.765382e-01 0.010 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.771339e-01 0.010 0 0
RNA Polymerase I Transcription R-HSA-73864 9.775541e-01 0.010 0 0
ABC transporter disorders R-HSA-5619084 9.775541e-01 0.010 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.775541e-01 0.010 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.775552e-01 0.010 0 0
Translation R-HSA-72766 9.779558e-01 0.010 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.785260e-01 0.009 0 0
Peptide hormone metabolism R-HSA-2980736 9.791886e-01 0.009 0 0
Signaling by MET R-HSA-6806834 9.794559e-01 0.009 0 0
Neddylation R-HSA-8951664 9.810431e-01 0.008 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.811968e-01 0.008 0 0
G alpha (i) signalling events R-HSA-418594 9.813365e-01 0.008 1 0
Neurotransmitter release cycle R-HSA-112310 9.873782e-01 0.006 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.877965e-01 0.005 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.889492e-01 0.005 0 0
Metabolism of proteins R-HSA-392499 9.895631e-01 0.005 0 0
tRNA processing R-HSA-72306 9.896216e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.906605e-01 0.004 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.906605e-01 0.004 0 0
Mitochondrial translation elongation R-HSA-5389840 9.911455e-01 0.004 0 0
Mitochondrial translation R-HSA-5368287 9.917030e-01 0.004 0 0
Mitochondrial translation initiation R-HSA-5368286 9.918967e-01 0.004 0 0
Regulation of insulin secretion R-HSA-422356 9.918967e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.925842e-01 0.003 0 0
Diseases of glycosylation R-HSA-3781865 9.936773e-01 0.003 0 0
Mitochondrial translation termination R-HSA-5419276 9.952406e-01 0.002 0 0
Arachidonate metabolism R-HSA-2142753 9.953787e-01 0.002 0 0
Antimicrobial peptides R-HSA-6803157 9.956447e-01 0.002 0 0
Keratinization R-HSA-6805567 9.972462e-01 0.001 0 0
Regulation of Complement cascade R-HSA-977606 9.978593e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.980412e-01 0.001 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.984996e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.985648e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.986343e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.988654e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.991315e-01 0.000 0 0
Complement cascade R-HSA-166658 9.992633e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.993260e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.994102e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.994483e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.995681e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998315e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999325e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999419e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999475e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999619e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999740e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999745e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999841e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999884e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999889e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999928e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999967e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999984e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999998e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 3.330669e-16 15.477 0 0
Recycling pathway of L1 R-HSA-437239 2.331468e-15 14.632 0 0
Cell Cycle R-HSA-1640170 8.937295e-14 13.049 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.245670e-13 12.905 0 0
M Phase R-HSA-68886 1.725287e-13 12.763 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.351586e-13 12.197 1 1
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.523182e-13 12.069 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.344924e-12 11.871 0 0
Cell Cycle, Mitotic R-HSA-69278 1.662559e-12 11.779 0 0
Autophagy R-HSA-9612973 1.834866e-12 11.736 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.977285e-12 11.526 0 0
Macroautophagy R-HSA-1632852 3.325562e-12 11.478 0 0
PKR-mediated signaling R-HSA-9833482 4.671707e-12 11.331 0 0
Post NMDA receptor activation events R-HSA-438064 4.463319e-12 11.350 1 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.550116e-12 11.256 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.327294e-12 11.273 0 0
Selective autophagy R-HSA-9663891 5.550116e-12 11.256 0 0
HSF1-dependent transactivation R-HSA-3371571 6.463718e-12 11.190 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.428990e-11 10.615 1 0
Mitotic Prometaphase R-HSA-68877 8.130163e-11 10.090 0 0
Attenuation phase R-HSA-3371568 9.183776e-11 10.037 0 0
Aggrephagy R-HSA-9646399 9.183776e-11 10.037 0 0
L1CAM interactions R-HSA-373760 9.492462e-11 10.023 0 0
HSF1 activation R-HSA-3371511 2.179786e-10 9.662 0 0
Gap junction trafficking and regulation R-HSA-157858 2.216460e-10 9.654 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.140491e-10 9.669 0 0
Gap junction trafficking R-HSA-190828 4.177152e-10 9.379 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.197790e-10 9.284 0 0
Cell-Cell communication R-HSA-1500931 1.395264e-09 8.855 0 0
HCMV Early Events R-HSA-9609690 1.678314e-09 8.775 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.781090e-09 8.749 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.350293e-09 8.629 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.437540e-09 8.613 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.116953e-09 8.506 0 0
Separation of Sister Chromatids R-HSA-2467813 7.304766e-09 8.136 0 0
Gap junction assembly R-HSA-190861 8.415485e-09 8.075 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.043262e-08 7.982 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.232596e-08 7.909 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.587590e-08 7.799 0 0
Membrane Trafficking R-HSA-199991 3.175820e-08 7.498 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.649677e-08 7.438 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.755323e-08 7.425 0 0
Mitotic Anaphase R-HSA-68882 5.034063e-08 7.298 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.530803e-08 7.257 0 0
Mitotic Prophase R-HSA-68875 7.129182e-08 7.147 0 0
G2/M Transition R-HSA-69275 8.936438e-08 7.049 0 0
Signal Transduction R-HSA-162582 9.175684e-08 7.037 1 0
HCMV Infection R-HSA-9609646 1.078364e-07 6.967 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.090670e-07 6.962 0 0
Developmental Biology R-HSA-1266738 1.273116e-07 6.895 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.428248e-07 6.845 0 0
Signaling by VEGF R-HSA-194138 1.526627e-07 6.816 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.554157e-07 6.809 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.770982e-07 6.752 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.768141e-07 6.558 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.768141e-07 6.558 0 0
Cell junction organization R-HSA-446728 3.517947e-07 6.454 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.613559e-07 6.442 0 0
Cell Cycle Checkpoints R-HSA-69620 6.030766e-07 6.220 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.595871e-07 6.181 0 0
Kinesins R-HSA-983189 6.595871e-07 6.181 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.891709e-07 6.162 0 0
Signaling by ALK in cancer R-HSA-9700206 6.891709e-07 6.162 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.369418e-06 5.863 0 0
HDACs deacetylate histones R-HSA-3214815 1.417980e-06 5.848 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.417980e-06 5.848 0 0
Interferon Signaling R-HSA-913531 1.451567e-06 5.838 0 0
Influenza Infection R-HSA-168255 1.588394e-06 5.799 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.606850e-06 5.794 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.724136e-06 5.763 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.848815e-06 5.733 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.282952e-06 5.642 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.346529e-06 5.630 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.421235e-06 5.616 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.421235e-06 5.616 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.378298e-06 5.471 0 0
Viral Infection Pathways R-HSA-9824446 3.384270e-06 5.471 0 0
MTOR signalling R-HSA-165159 3.674555e-06 5.435 0 0
Metabolism of RNA R-HSA-8953854 3.767718e-06 5.424 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.010961e-06 5.397 0 0
Cilium Assembly R-HSA-5617833 4.125119e-06 5.385 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.652463e-06 5.332 0 0
Protein folding R-HSA-391251 5.156936e-06 5.288 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.156936e-06 5.288 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.066329e-06 5.295 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.139761e-06 5.289 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.293638e-06 5.201 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.834250e-06 5.106 0 0
Apoptotic execution phase R-HSA-75153 7.890070e-06 5.103 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.227242e-06 5.035 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.866890e-06 5.052 1 0
Vesicle-mediated transport R-HSA-5653656 9.354451e-06 5.029 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.007765e-05 4.997 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.065877e-05 4.972 0 0
Diseases of programmed cell death R-HSA-9645723 1.097693e-05 4.960 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.165513e-05 4.933 0 0
Adherens junctions interactions R-HSA-418990 1.381253e-05 4.860 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.387561e-05 4.858 0 0
Glycolysis R-HSA-70171 1.508027e-05 4.822 0 0
Chromatin modifying enzymes R-HSA-3247509 1.600844e-05 4.796 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.772293e-05 4.751 0 0
Cell-cell junction organization R-HSA-421270 1.940460e-05 4.712 0 0
EPH-Ephrin signaling R-HSA-2682334 2.004857e-05 4.698 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.513291e-05 4.600 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.513291e-05 4.600 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.321229e-05 4.634 0 0
Centrosome maturation R-HSA-380287 3.014446e-05 4.521 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.041321e-05 4.517 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.168157e-05 4.499 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.168157e-05 4.499 0 0
DNA methylation R-HSA-5334118 3.512511e-05 4.454 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.818515e-05 4.418 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.944052e-05 4.404 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.944052e-05 4.404 0 0
Peptide chain elongation R-HSA-156902 4.224247e-05 4.374 0 0
Chromatin organization R-HSA-4839726 4.313330e-05 4.365 0 0
DNA Double Strand Break Response R-HSA-5693606 4.368710e-05 4.360 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.501532e-05 4.347 0 0
HATs acetylate histones R-HSA-3214847 4.860437e-05 4.313 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.243998e-05 4.280 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.306941e-05 4.275 0 0
Intraflagellar transport R-HSA-5620924 5.610842e-05 4.251 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.855686e-05 4.232 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.327327e-05 4.199 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.595008e-05 4.181 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.509940e-05 4.124 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.092897e-05 4.092 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.885346e-05 4.051 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.268060e-05 4.033 0 0
Ephrin signaling R-HSA-3928664 9.268060e-05 4.033 0 0
G2/M Checkpoints R-HSA-69481 9.551368e-05 4.020 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.113883e-04 3.953 0 0
Glucose metabolism R-HSA-70326 1.123574e-04 3.949 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.180220e-04 3.928 0 0
Immune System R-HSA-168256 1.189048e-04 3.925 0 0
Gene Silencing by RNA R-HSA-211000 1.190653e-04 3.924 0 0
Cellular Senescence R-HSA-2559583 1.207783e-04 3.918 0 0
Defective pyroptosis R-HSA-9710421 1.224371e-04 3.912 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.382065e-04 3.859 0 0
Packaging Of Telomere Ends R-HSA-171306 1.411655e-04 3.850 0 0
Nephrin family interactions R-HSA-373753 1.540093e-04 3.812 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.411655e-04 3.850 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.564004e-04 3.806 0 0
Nucleosome assembly R-HSA-774815 1.663394e-04 3.779 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.663394e-04 3.779 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.711397e-04 3.767 0 0
Signaling by EGFR R-HSA-177929 1.778320e-04 3.750 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.875272e-04 3.727 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.881372e-04 3.726 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.881372e-04 3.726 0 0
MHC class II antigen presentation R-HSA-2132295 1.888809e-04 3.724 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.027624e-04 3.693 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.074125e-04 3.683 0 0
Signaling by ROBO receptors R-HSA-376176 2.154451e-04 3.667 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.195752e-04 3.658 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.276834e-04 3.643 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.511058e-04 3.600 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.565703e-04 3.591 0 0
snRNP Assembly R-HSA-191859 2.615788e-04 3.582 0 0
Metabolism of non-coding RNA R-HSA-194441 2.615788e-04 3.582 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.681359e-04 3.572 0 0
Platelet degranulation R-HSA-114608 2.840423e-04 3.547 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.960101e-04 3.529 0 0
ESR-mediated signaling R-HSA-8939211 2.974001e-04 3.527 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.015008e-04 3.521 0 0
mTORC1-mediated signalling R-HSA-166208 3.039250e-04 3.517 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.130415e-04 3.504 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.130415e-04 3.504 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.364079e-04 3.473 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.602676e-04 3.443 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.639881e-04 3.439 0 0
Eukaryotic Translation Termination R-HSA-72764 3.691369e-04 3.433 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.268250e-04 3.370 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.215838e-04 3.375 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.173210e-04 3.380 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.268250e-04 3.370 0 0
Cellular response to starvation R-HSA-9711097 4.540987e-04 3.343 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.375790e-04 3.359 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.268250e-04 3.370 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.185099e-04 3.378 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.820948e-04 3.317 0 0
Interleukin-12 signaling R-HSA-9020591 4.820948e-04 3.317 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.958973e-04 3.305 0 0
Meiotic synapsis R-HSA-1221632 4.964948e-04 3.304 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.030362e-04 3.298 0 0
Signaling by Hippo R-HSA-2028269 5.187547e-04 3.285 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.204594e-04 3.284 1 0
Mitotic Spindle Checkpoint R-HSA-69618 5.766876e-04 3.239 0 0
Nuclear import of Rev protein R-HSA-180746 5.899107e-04 3.229 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.899107e-04 3.229 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.899107e-04 3.229 0 0
RNA Polymerase I Transcription R-HSA-73864 5.908722e-04 3.229 0 0
Apoptosis R-HSA-109581 5.921507e-04 3.228 0 0
Selenocysteine synthesis R-HSA-2408557 6.283296e-04 3.202 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.488092e-04 3.188 0 0
Signaling by RAS mutants R-HSA-6802949 8.333063e-04 3.079 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.333063e-04 3.079 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.333063e-04 3.079 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.333063e-04 3.079 0 0
Viral mRNA Translation R-HSA-192823 7.434463e-04 3.129 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.350458e-04 3.134 0 0
Regulation of CDH1 Function R-HSA-9764561 8.018860e-04 3.096 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.921946e-04 3.101 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.407576e-04 3.075 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.708701e-04 3.060 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.875894e-04 3.052 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.985197e-04 3.046 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.985197e-04 3.046 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.255176e-04 3.034 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.255176e-04 3.034 0 0
Cleavage of the damaged purine R-HSA-110331 9.255176e-04 3.034 0 0
Transmission across Chemical Synapses R-HSA-112315 9.419181e-04 3.026 1 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.000554e-03 3.000 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.027730e-03 2.988 0 0
Homology Directed Repair R-HSA-5693538 1.057470e-03 2.976 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.066349e-03 2.972 0 0
Depurination R-HSA-73927 1.066349e-03 2.972 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.201078e-03 2.920 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.243359e-03 2.905 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.253725e-03 2.902 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.253725e-03 2.902 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.305581e-03 2.884 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.305581e-03 2.884 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.473255e-03 2.832 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.523282e-03 2.817 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.523282e-03 2.817 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.399216e-03 2.854 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.594038e-03 2.798 0 0
Semaphorin interactions R-HSA-373755 1.535790e-03 2.814 0 0
Programmed Cell Death R-HSA-5357801 1.444106e-03 2.840 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.473212e-03 2.832 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.397384e-03 2.855 0 0
Interleukin-12 family signaling R-HSA-447115 1.492009e-03 2.826 0 0
Formation of annular gap junctions R-HSA-196025 1.599260e-03 2.796 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.707170e-03 2.768 0 0
Hedgehog 'off' state R-HSA-5610787 1.710748e-03 2.767 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.759266e-03 2.755 0 0
DCC mediated attractive signaling R-HSA-418885 1.759266e-03 2.755 0 0
Protein methylation R-HSA-8876725 1.759266e-03 2.755 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.759266e-03 2.755 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.874339e-03 2.727 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.876268e-03 2.727 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.902424e-03 2.721 0 0
Smooth Muscle Contraction R-HSA-445355 1.906298e-03 2.720 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.042779e-03 2.690 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.047829e-03 2.689 0 0
Depyrimidination R-HSA-73928 2.047829e-03 2.689 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.081071e-03 2.682 0 0
Translation initiation complex formation R-HSA-72649 2.123555e-03 2.673 0 0
Gap junction degradation R-HSA-190873 2.187739e-03 2.660 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.187739e-03 2.660 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.306480e-03 2.637 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.314837e-03 2.635 0 0
Striated Muscle Contraction R-HSA-390522 2.349136e-03 2.629 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.349136e-03 2.629 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.597570e-03 2.585 0 0
Netrin-1 signaling R-HSA-373752 2.597570e-03 2.585 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.617081e-03 2.582 0 0
HCMV Late Events R-HSA-9610379 2.636682e-03 2.579 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.689718e-03 2.570 0 0
Disorders of Developmental Biology R-HSA-9675151 2.700444e-03 2.569 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.731812e-03 2.564 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.825560e-03 2.549 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.834677e-03 2.547 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.712575e-03 2.430 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.287516e-03 2.483 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.287516e-03 2.483 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.066967e-03 2.513 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.256419e-03 2.487 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.486292e-03 2.458 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.575453e-03 2.447 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.256419e-03 2.487 0 0
Chromosome Maintenance R-HSA-73886 3.448384e-03 2.462 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.540147e-03 2.451 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.256419e-03 2.487 0 0
RET signaling R-HSA-8853659 3.483374e-03 2.458 0 0
Adaptive Immune System R-HSA-1280218 3.060980e-03 2.514 0 0
Signaling by NOTCH R-HSA-157118 3.649900e-03 2.438 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.598483e-03 2.444 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.483374e-03 2.458 0 0
Hemostasis R-HSA-109582 3.260859e-03 2.487 0 0
Infectious disease R-HSA-5663205 2.980721e-03 2.526 0 0
Signaling by NTRKs R-HSA-166520 3.730502e-03 2.428 0 0
Telomere Maintenance R-HSA-157579 3.830150e-03 2.417 0 0
Signaling by ERBB2 R-HSA-1227986 3.874426e-03 2.412 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.914776e-03 2.407 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.937955e-03 2.405 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.941480e-03 2.404 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.961213e-03 2.402 0 0
Muscle contraction R-HSA-397014 4.441855e-03 2.352 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.552163e-03 2.342 0 0
Protein ubiquitination R-HSA-8852135 4.601719e-03 2.337 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.601719e-03 2.337 0 0
Neuronal System R-HSA-112316 4.618239e-03 2.336 1 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.658876e-03 2.332 0 0
Ribosome-associated quality control R-HSA-9948299 4.716132e-03 2.326 0 0
Signaling by Hedgehog R-HSA-5358351 4.716132e-03 2.326 0 0
DNA Replication R-HSA-69306 4.915832e-03 2.308 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.923339e-03 2.308 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.993137e-03 2.302 0 0
Disease R-HSA-1643685 5.138505e-03 2.289 0 0
Death Receptor Signaling R-HSA-73887 5.186238e-03 2.285 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.208929e-03 2.283 0 0
Meiotic recombination R-HSA-912446 5.472952e-03 2.262 0 0
Base Excision Repair R-HSA-73884 5.492550e-03 2.260 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.585565e-03 2.253 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.629669e-03 2.250 0 0
Neutrophil degranulation R-HSA-6798695 5.686606e-03 2.245 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.946415e-03 2.226 0 0
Disorders of Nervous System Development R-HSA-9697154 6.021158e-03 2.220 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.021158e-03 2.220 0 0
Pervasive developmental disorders R-HSA-9005895 6.021158e-03 2.220 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.242920e-03 2.205 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.568622e-03 2.183 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.568622e-03 2.183 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.757193e-03 2.170 0 0
MAP2K and MAPK activation R-HSA-5674135 6.948752e-03 2.158 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.267123e-03 2.139 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.413776e-03 2.130 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.881755e-03 2.103 0 0
Manipulation of host energy metabolism R-HSA-9636667 8.112519e-03 2.091 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.140346e-03 2.089 0 0
TBC/RABGAPs R-HSA-8854214 8.535635e-03 2.069 0 0
Integrin signaling R-HSA-354192 8.614363e-03 2.065 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.688438e-03 2.061 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.111797e-03 2.040 0 0
Meiosis R-HSA-1500620 9.769825e-03 2.010 0 0
Signaling by Interleukins R-HSA-449147 1.011656e-02 1.995 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.037386e-02 1.984 0 0
rRNA processing R-HSA-72312 1.040881e-02 1.983 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.041864e-02 1.982 0 0
SOS-mediated signalling R-HSA-112412 1.046647e-02 1.980 0 0
Diseases of cellular response to stress R-HSA-9675132 1.400809e-02 1.854 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.400809e-02 1.854 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.400809e-02 1.854 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.348704e-02 1.870 1 1
Type I hemidesmosome assembly R-HSA-446107 1.348704e-02 1.870 0 0
p38MAPK events R-HSA-171007 1.079992e-02 1.967 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.281283e-02 1.892 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.139491e-02 1.943 0 0
mRNA Splicing R-HSA-72172 1.300154e-02 1.886 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.079992e-02 1.967 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.324867e-02 1.878 0 0
RAF activation R-HSA-5673000 1.081142e-02 1.966 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.204681e-02 1.919 0 0
Oncogene Induced Senescence R-HSA-2559585 1.204681e-02 1.919 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.058414e-02 1.975 0 0
Co-stimulation by CD28 R-HSA-389356 1.364822e-02 1.865 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.079992e-02 1.967 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.140646e-02 1.943 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.139491e-02 1.943 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.079992e-02 1.967 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.143340e-02 1.942 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.416232e-02 1.849 0 0
tRNA processing in the nucleus R-HSA-6784531 1.420323e-02 1.848 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.420323e-02 1.848 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.488317e-02 1.827 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.498735e-02 1.824 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.585157e-02 1.800 0 0
Rab regulation of trafficking R-HSA-9007101 1.586251e-02 1.800 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.627183e-02 1.789 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.627183e-02 1.789 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.687239e-02 1.773 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.687239e-02 1.773 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.695331e-02 1.771 1 1
Lipophagy R-HSA-9613354 1.695331e-02 1.771 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.751985e-02 1.756 0 0
SARS-CoV Infections R-HSA-9679506 1.784886e-02 1.748 0 0
Selenoamino acid metabolism R-HSA-2408522 1.807224e-02 1.743 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.948304e-02 1.710 0 0
Amyloid fiber formation R-HSA-977225 1.964439e-02 1.707 0 0
GAB1 signalosome R-HSA-180292 2.022773e-02 1.694 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.022773e-02 1.694 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.022773e-02 1.694 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.087117e-02 1.680 1 1
EGFR Transactivation by Gastrin R-HSA-2179392 2.087117e-02 1.680 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.087117e-02 1.680 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.109951e-02 1.676 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.109951e-02 1.676 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.126142e-02 1.672 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.147345e-02 1.668 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.159508e-02 1.666 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.191036e-02 1.659 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.230412e-02 1.652 0 0
Host Interactions of HIV factors R-HSA-162909 2.259689e-02 1.646 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.317943e-02 1.635 0 0
Rap1 signalling R-HSA-392517 2.317943e-02 1.635 0 0
Activation of BH3-only proteins R-HSA-114452 2.344977e-02 1.630 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.524303e-02 1.598 0 0
PECAM1 interactions R-HSA-210990 2.524303e-02 1.598 0 0
NRAGE signals death through JNK R-HSA-193648 2.588097e-02 1.587 0 0
EGFR downregulation R-HSA-182971 2.596268e-02 1.586 0 0
Downstream signal transduction R-HSA-186763 2.596268e-02 1.586 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.619083e-02 1.582 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.637947e-02 1.579 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.688155e-02 1.571 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.845367e-02 1.546 0 0
Regulation of gap junction activity R-HSA-191650 2.974379e-02 1.527 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.974379e-02 1.527 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.974379e-02 1.527 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.974379e-02 1.527 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.974379e-02 1.527 0 0
MTF1 activates gene expression R-HSA-5660489 2.974379e-02 1.527 0 0
Signalling to RAS R-HSA-167044 2.983144e-02 1.525 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.006811e-02 1.522 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.041992e-02 1.517 0 0
Translation R-HSA-72766 3.196784e-02 1.495 0 0
DAG and IP3 signaling R-HSA-1489509 3.268227e-02 1.486 1 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.268227e-02 1.486 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.353801e-02 1.474 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.353801e-02 1.474 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.353801e-02 1.474 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.534288e-02 1.452 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.534288e-02 1.452 0 0
Gene expression (Transcription) R-HSA-74160 3.565979e-02 1.448 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.648551e-02 1.438 0 0
Mitophagy R-HSA-5205647 3.769925e-02 1.424 0 0
Co-inhibition by PD-1 R-HSA-389948 3.872506e-02 1.412 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.933506e-02 1.405 0 0
IRS activation R-HSA-74713 3.933506e-02 1.405 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.933506e-02 1.405 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.933506e-02 1.405 0 0
Gluconeogenesis R-HSA-70263 4.083651e-02 1.389 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.343166e-02 1.362 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.343166e-02 1.362 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.992318e-02 1.302 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.140374e-02 1.212 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.078879e-02 1.216 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.619905e-02 1.335 0 0
Long-term potentiation R-HSA-9620244 5.093364e-02 1.293 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.116688e-02 1.213 0 0
CaM pathway R-HSA-111997 4.460896e-02 1.351 1 0
Calmodulin induced events R-HSA-111933 4.460896e-02 1.351 1 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.696255e-02 1.328 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.002382e-02 1.301 0 0
CREB phosphorylation R-HSA-199920 6.140374e-02 1.212 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.379515e-02 1.269 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.140374e-02 1.212 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.832919e-02 1.316 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.379515e-02 1.269 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.721547e-02 1.326 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.619905e-02 1.335 0 0
Developmental Cell Lineages R-HSA-9734767 5.240996e-02 1.281 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.533838e-02 1.344 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.992318e-02 1.302 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.142619e-02 1.383 0 0
Signaling by PTK6 R-HSA-8848021 4.142619e-02 1.383 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.832919e-02 1.316 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.493387e-02 1.260 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.172128e-02 1.380 0 0
Syndecan interactions R-HSA-3000170 4.172128e-02 1.380 0 0
Sensory processing of sound R-HSA-9659379 4.293517e-02 1.367 0 0
Neurodegenerative Diseases R-HSA-8863678 4.619905e-02 1.335 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.619905e-02 1.335 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.116688e-02 1.213 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.379515e-02 1.269 0 0
Ub-specific processing proteases R-HSA-5689880 5.133879e-02 1.290 0 0
Inositol phosphate metabolism R-HSA-1483249 5.337707e-02 1.273 0 0
Regulation of TP53 Activity R-HSA-5633007 5.822325e-02 1.235 0 0
PTEN Regulation R-HSA-6807070 4.924953e-02 1.308 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.203561e-02 1.207 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.566646e-02 1.183 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.818339e-02 1.166 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.818339e-02 1.166 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.818339e-02 1.166 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.842012e-02 1.165 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.842012e-02 1.165 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.959770e-02 1.157 0 0
Deubiquitination R-HSA-5688426 6.967167e-02 1.157 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.104425e-02 1.148 0 0
Signaling by Erythropoietin R-HSA-9006335 7.240147e-02 1.140 0 0
Late endosomal microautophagy R-HSA-9615710 7.240147e-02 1.140 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.367946e-02 1.133 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.367946e-02 1.133 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.367946e-02 1.133 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.367946e-02 1.133 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.367946e-02 1.133 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.367946e-02 1.133 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.367946e-02 1.133 0 0
Ca-dependent events R-HSA-111996 7.438180e-02 1.129 1 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.838537e-02 1.106 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.838537e-02 1.106 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.838799e-02 1.106 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.082335e-02 1.092 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.110546e-02 1.091 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.411770e-02 1.075 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.447099e-02 1.073 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.497953e-02 1.071 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.497953e-02 1.071 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.497953e-02 1.071 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 8.497953e-02 1.071 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 8.497953e-02 1.071 0 0
TICAM1 deficiency - HSE R-HSA-5602566 8.497953e-02 1.071 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.497953e-02 1.071 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 8.497953e-02 1.071 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.497953e-02 1.071 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 8.497953e-02 1.071 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 8.497953e-02 1.071 0 0
Inhibition of PKR R-HSA-169131 8.497953e-02 1.071 0 0
RNA Polymerase II Transcription R-HSA-73857 8.639864e-02 1.063 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.665985e-02 1.062 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.665985e-02 1.062 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.665985e-02 1.062 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.665985e-02 1.062 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 8.665985e-02 1.062 0 0
MAP kinase activation R-HSA-450294 9.004042e-02 1.046 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.255509e-02 1.034 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.262625e-02 1.033 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.262625e-02 1.033 0 0
Post-translational protein modification R-HSA-597592 9.295055e-02 1.032 0 0
Signaling by PDGF R-HSA-186797 9.476293e-02 1.023 0 0
HIV Life Cycle R-HSA-162587 9.489567e-02 1.023 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.524190e-02 1.021 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.774737e-02 1.010 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.774737e-02 1.010 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.774737e-02 1.010 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.793010e-02 1.009 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.793010e-02 1.009 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.868541e-02 1.006 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.868541e-02 1.006 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.868541e-02 1.006 0 0
MAPK family signaling cascades R-HSA-5683057 9.987232e-02 1.001 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.002607e-01 0.999 0 0
Calcineurin activates NFAT R-HSA-2025928 1.002607e-01 0.999 0 0
ALK mutants bind TKIs R-HSA-9700645 1.002607e-01 0.999 0 0
Unwinding of DNA R-HSA-176974 1.002607e-01 0.999 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.002607e-01 0.999 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.002607e-01 0.999 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.002607e-01 0.999 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.002607e-01 0.999 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.008771e-01 0.996 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.008771e-01 0.996 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.014738e-01 0.994 0 0
Protein hydroxylation R-HSA-9629569 1.014738e-01 0.994 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.046530e-01 0.980 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.046530e-01 0.980 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.050143e-01 0.979 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.051297e-01 0.978 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.247252e-01 0.904 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.247252e-01 0.904 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.247252e-01 0.904 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.247252e-01 0.904 0 0
TRAF3 deficiency - HSE R-HSA-5602571 1.247252e-01 0.904 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.247252e-01 0.904 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.247252e-01 0.904 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.247252e-01 0.904 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.627468e-01 0.788 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.627468e-01 0.788 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.627468e-01 0.788 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.627468e-01 0.788 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.627468e-01 0.788 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.627468e-01 0.788 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 1.991189e-01 0.701 0 0
PLC-gamma1 signalling R-HSA-167021 1.991189e-01 0.701 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.991189e-01 0.701 0 0
MET activates PTPN11 R-HSA-8865999 1.991189e-01 0.701 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.991189e-01 0.701 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.991189e-01 0.701 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.144039e-01 0.942 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.144039e-01 0.942 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.144039e-01 0.942 0 0
2-LTR circle formation R-HSA-164843 1.144039e-01 0.942 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.144039e-01 0.942 0 0
Activation of RAC1 R-HSA-428540 1.440319e-01 0.842 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.440319e-01 0.842 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.593871e-01 0.798 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.593871e-01 0.798 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.750244e-01 0.757 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.106431e-01 0.956 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.201167e-01 0.920 0 0
Erythropoietin activates RAS R-HSA-9027284 2.069365e-01 0.684 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.069365e-01 0.684 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.069365e-01 0.684 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.069365e-01 0.684 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.117743e-01 0.952 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.714234e-01 0.766 0 0
mRNA 3'-end processing R-HSA-72187 1.314312e-01 0.881 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.843704e-01 0.734 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.313764e-01 0.881 0 0
MET promotes cell motility R-HSA-8875878 1.422763e-01 0.847 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.440319e-01 0.842 0 0
Integration of provirus R-HSA-162592 1.440319e-01 0.842 0 0
PI3K/AKT activation R-HSA-198203 1.144039e-01 0.942 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.290167e-01 0.889 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.191044e-01 0.924 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.934504e-01 0.713 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.605828e-01 0.794 0 0
Generation of second messenger molecules R-HSA-202433 1.586329e-01 0.800 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.164080e-01 0.934 0 0
Formation of the posterior neural plate R-HSA-9832991 1.290167e-01 0.889 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.593871e-01 0.798 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.843704e-01 0.734 0 0
PLC beta mediated events R-HSA-112043 1.952087e-01 0.710 1 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.488653e-01 0.827 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.513252e-01 0.820 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.750244e-01 0.757 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.908907e-01 0.719 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.908907e-01 0.719 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.069365e-01 0.684 0 0
DARPP-32 events R-HSA-180024 2.047161e-01 0.689 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.728926e-01 0.762 0 0
ERK/MAPK targets R-HSA-198753 1.106431e-01 0.956 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.670599e-01 0.777 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.047161e-01 0.689 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 1.247252e-01 0.904 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.247252e-01 0.904 0 0
Transport of connexins along the secretory pathway R-HSA-190827 1.247252e-01 0.904 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.627468e-01 0.788 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.627468e-01 0.788 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.627468e-01 0.788 0 0
MET interacts with TNS proteins R-HSA-8875513 1.991189e-01 0.701 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.440319e-01 0.842 0 0
Regulation of KIT signaling R-HSA-1433559 1.908907e-01 0.719 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.069365e-01 0.684 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.501848e-01 0.823 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.823471e-01 0.739 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.952087e-01 0.710 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.257836e-01 0.900 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 1.422763e-01 0.847 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.756419e-01 0.755 0 0
p75NTR signals via NF-kB R-HSA-193639 2.069365e-01 0.684 0 0
Signaling by MET R-HSA-6806834 2.001038e-01 0.699 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.792423e-01 0.747 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.593871e-01 0.798 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.144039e-01 0.942 0 0
Signal attenuation R-HSA-74749 1.144039e-01 0.942 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.289477e-01 0.890 0 0
Ion homeostasis R-HSA-5578775 1.585106e-01 0.800 0 0
RAB geranylgeranylation R-HSA-8873719 1.876408e-01 0.727 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.047161e-01 0.689 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.028810e-01 0.693 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.201167e-01 0.920 0 0
HIV Infection R-HSA-162906 2.142298e-01 0.669 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.867199e-01 0.729 0 0
Interleukin-17 signaling R-HSA-448424 1.370922e-01 0.863 0 0
DNA Repair R-HSA-73894 1.288298e-01 0.890 0 0
Signaling by FGFR4 R-HSA-5654743 1.932373e-01 0.714 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.247252e-01 0.904 0 0
Oligomerization of connexins into connexons R-HSA-190704 1.247252e-01 0.904 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.750244e-01 0.757 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.823471e-01 0.739 0 0
Signaling by FGFR1 R-HSA-5654736 1.585106e-01 0.800 0 0
Signaling by FGFR3 R-HSA-5654741 2.113518e-01 0.675 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.503690e-01 0.823 0 0
Myogenesis R-HSA-525793 1.714234e-01 0.766 0 0
Signaling by TGFB family members R-HSA-9006936 1.735209e-01 0.761 0 0
Generic Transcription Pathway R-HSA-212436 1.383378e-01 0.859 0 0
Metabolism of proteins R-HSA-392499 1.836967e-01 0.736 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.144039e-01 0.942 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.440319e-01 0.842 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.593871e-01 0.798 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.201167e-01 0.920 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.503690e-01 0.823 0 0
Platelet calcium homeostasis R-HSA-418360 2.047161e-01 0.689 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.606967e-01 0.794 0 0
Reproduction R-HSA-1474165 1.201532e-01 0.920 0 0
Formation of the anterior neural plate R-HSA-9823739 2.069365e-01 0.684 0 0
Interleukin-7 signaling R-HSA-1266695 1.606967e-01 0.794 0 0
Signalling to ERKs R-HSA-187687 1.191044e-01 0.924 0 0
Signaling by ALK R-HSA-201556 1.503690e-01 0.823 0 0
Mitochondrial biogenesis R-HSA-1592230 1.335527e-01 0.874 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.512950e-01 0.820 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.201167e-01 0.920 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.604584e-01 0.795 0 0
TNF signaling R-HSA-75893 1.585106e-01 0.800 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.331780e-01 0.876 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.106431e-01 0.956 0 0
Signaling by Leptin R-HSA-2586552 1.144039e-01 0.942 0 0
Signal regulatory protein family interactions R-HSA-391160 1.908907e-01 0.719 0 0
G alpha (12/13) signalling events R-HSA-416482 1.867199e-01 0.729 0 0
Activation of the pre-replicative complex R-HSA-68962 2.161273e-01 0.665 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.161273e-01 0.665 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 2.161273e-01 0.665 0 0
Potential therapeutics for SARS R-HSA-9679191 2.180542e-01 0.661 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 2.205827e-01 0.656 0 0
Signaling by TGFBR3 R-HSA-9839373 2.205827e-01 0.656 0 0
Phosphorylation of the APC/C R-HSA-176412 2.231164e-01 0.651 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.231164e-01 0.651 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 2.231164e-01 0.651 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.231164e-01 0.651 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.231164e-01 0.651 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.278651e-01 0.642 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.339131e-01 0.631 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.339131e-01 0.631 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.339131e-01 0.631 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.339131e-01 0.631 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.339131e-01 0.631 0 0
NADE modulates death signalling R-HSA-205025 2.339131e-01 0.631 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.339131e-01 0.631 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.339131e-01 0.631 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.349926e-01 0.629 0 0
DNA strand elongation R-HSA-69190 2.393209e-01 0.621 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.393209e-01 0.621 0 0
NGF-stimulated transcription R-HSA-9031628 2.393495e-01 0.621 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.393886e-01 0.621 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.393886e-01 0.621 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.393886e-01 0.621 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.393886e-01 0.621 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.393886e-01 0.621 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.393886e-01 0.621 0 0
Response to metal ions R-HSA-5660526 2.393886e-01 0.621 0 0
G-protein mediated events R-HSA-112040 2.426297e-01 0.615 1 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.433914e-01 0.614 0 0
Degradation of CDH1 R-HSA-9766229 2.488687e-01 0.604 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.494476e-01 0.603 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.510715e-01 0.600 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.510715e-01 0.600 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.510715e-01 0.600 0 0
Asparagine N-linked glycosylation R-HSA-446203 2.520122e-01 0.599 0 0
Signaling by WNT R-HSA-195721 2.528729e-01 0.597 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.530239e-01 0.597 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.557147e-01 0.592 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.557147e-01 0.592 0 0
Innate Immune System R-HSA-168249 2.654445e-01 0.576 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.671976e-01 0.573 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.671976e-01 0.573 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.671976e-01 0.573 0 0
Suppression of autophagy R-HSA-9636569 2.671976e-01 0.573 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.671976e-01 0.573 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.671976e-01 0.573 0 0
Pyrophosphate hydrolysis R-HSA-71737 2.671976e-01 0.573 0 0
The phototransduction cascade R-HSA-2514856 2.681378e-01 0.572 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.720592e-01 0.565 0 0
PKA activation R-HSA-163615 2.720592e-01 0.565 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.722901e-01 0.565 0 0
Dual Incision in GG-NER R-HSA-5696400 2.748044e-01 0.561 0 0
eNOS activation R-HSA-203615 2.748044e-01 0.561 0 0
Neurexins and neuroligins R-HSA-6794361 2.778714e-01 0.556 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.867576e-01 0.542 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.867576e-01 0.542 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.868184e-01 0.542 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.876605e-01 0.541 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.883898e-01 0.540 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.883898e-01 0.540 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 2.883898e-01 0.540 0 0
The NLRP3 inflammasome R-HSA-844456 2.883898e-01 0.540 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.927039e-01 0.534 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.937054e-01 0.532 0 0
IRE1alpha activates chaperones R-HSA-381070 2.941581e-01 0.531 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.990380e-01 0.524 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.990380e-01 0.524 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.990380e-01 0.524 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.990380e-01 0.524 0 0
Signaling by MAPK mutants R-HSA-9652817 2.990380e-01 0.524 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.990380e-01 0.524 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.990380e-01 0.524 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.990380e-01 0.524 0 0
Cam-PDE 1 activation R-HSA-111957 2.990380e-01 0.524 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.990380e-01 0.524 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.990380e-01 0.524 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.990380e-01 0.524 0 0
Signaling by FGFR in disease R-HSA-1226099 3.012300e-01 0.521 0 0
Signaling by NOTCH4 R-HSA-9013694 3.012300e-01 0.521 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.046770e-01 0.516 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.046770e-01 0.516 0 0
Signal transduction by L1 R-HSA-445144 3.046770e-01 0.516 0 0
Signaling by NOTCH3 R-HSA-9012852 3.073742e-01 0.512 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.170942e-01 0.499 0 0
S Phase R-HSA-69242 3.199106e-01 0.495 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.208938e-01 0.494 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.208938e-01 0.494 0 0
Basigin interactions R-HSA-210991 3.208938e-01 0.494 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.215920e-01 0.493 0 0
IRS-mediated signalling R-HSA-112399 3.272185e-01 0.485 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.272185e-01 0.485 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.294967e-01 0.482 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.294967e-01 0.482 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.294967e-01 0.482 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.294967e-01 0.482 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.294967e-01 0.482 0 0
Nef and signal transduction R-HSA-164944 3.294967e-01 0.482 0 0
Toll-like Receptor Cascades R-HSA-168898 3.325453e-01 0.478 0 0
RAS processing R-HSA-9648002 3.348353e-01 0.475 0 0
Pentose phosphate pathway R-HSA-71336 3.348353e-01 0.475 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.348353e-01 0.475 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.348353e-01 0.475 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.370155e-01 0.472 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.370155e-01 0.472 0 0
Serine metabolism R-HSA-977347 3.370155e-01 0.472 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.427886e-01 0.465 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.468586e-01 0.460 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.468586e-01 0.460 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.471354e-01 0.460 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.480651e-01 0.458 0 0
Signaling by FGFR2 R-HSA-5654738 3.530181e-01 0.452 0 0
Notch-HLH transcription pathway R-HSA-350054 3.530198e-01 0.452 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.530198e-01 0.452 0 0
Signaling by KIT in disease R-HSA-9669938 3.530198e-01 0.452 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.530198e-01 0.452 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.530198e-01 0.452 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.530198e-01 0.452 0 0
Signaling by FGFR R-HSA-190236 3.558546e-01 0.449 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.558546e-01 0.449 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.558546e-01 0.449 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.558546e-01 0.449 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.586337e-01 0.445 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.586337e-01 0.445 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.586337e-01 0.445 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.586337e-01 0.445 0 0
Recycling of eIF2:GDP R-HSA-72731 3.586337e-01 0.445 0 0
Disinhibition of SNARE formation R-HSA-114516 3.586337e-01 0.445 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.586337e-01 0.445 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.586337e-01 0.445 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.586337e-01 0.445 0 0
PTK6 Expression R-HSA-8849473 3.586337e-01 0.445 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.586337e-01 0.445 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.586337e-01 0.445 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.586337e-01 0.445 0 0
VLDL clearance R-HSA-8964046 3.586337e-01 0.445 0 0
Netrin mediated repulsion signals R-HSA-418886 3.586337e-01 0.445 0 0
CHL1 interactions R-HSA-447041 3.586337e-01 0.445 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.588605e-01 0.445 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.588605e-01 0.445 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.670700e-01 0.435 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.688867e-01 0.433 0 0
Growth hormone receptor signaling R-HSA-982772 3.688867e-01 0.433 0 0
Intra-Golgi traffic R-HSA-6811438 3.708303e-01 0.431 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.770243e-01 0.424 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.784455e-01 0.422 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.784455e-01 0.422 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.845977e-01 0.415 0 0
Deadenylation of mRNA R-HSA-429947 3.845977e-01 0.415 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.845977e-01 0.415 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.865063e-01 0.413 0 0
MET receptor recycling R-HSA-8875656 3.865063e-01 0.413 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.865063e-01 0.413 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.865063e-01 0.413 0 0
Activation of RAS in B cells R-HSA-1169092 3.865063e-01 0.413 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.865063e-01 0.413 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.865063e-01 0.413 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.865063e-01 0.413 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.865063e-01 0.413 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.865063e-01 0.413 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.865063e-01 0.413 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.903052e-01 0.409 0 0
Signaling by SCF-KIT R-HSA-1433557 3.946336e-01 0.404 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.946336e-01 0.404 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.946336e-01 0.404 0 0
IGF1R signaling cascade R-HSA-2428924 3.968925e-01 0.401 0 0
Insulin receptor signalling cascade R-HSA-74751 3.968925e-01 0.401 0 0
Ion transport by P-type ATPases R-HSA-936837 3.968925e-01 0.401 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.999267e-01 0.398 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.999267e-01 0.398 0 0
Tight junction interactions R-HSA-420029 4.001365e-01 0.398 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.001365e-01 0.398 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.001365e-01 0.398 0 0
TGFBR3 expression R-HSA-9839394 4.001365e-01 0.398 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.001365e-01 0.398 0 0
Opioid Signalling R-HSA-111885 4.027316e-01 0.395 1 0
Cellular response to chemical stress R-HSA-9711123 4.034123e-01 0.394 0 0
G1 Phase R-HSA-69236 4.064486e-01 0.391 0 0
Cyclin D associated events in G1 R-HSA-69231 4.064486e-01 0.391 0 0
RMTs methylate histone arginines R-HSA-3214858 4.064486e-01 0.391 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.067880e-01 0.391 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.131691e-01 0.384 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.131691e-01 0.384 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.131691e-01 0.384 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.131691e-01 0.384 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.131691e-01 0.384 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.131691e-01 0.384 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.131691e-01 0.384 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.131691e-01 0.384 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.131691e-01 0.384 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.131691e-01 0.384 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.131691e-01 0.384 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.138268e-01 0.383 0 0
MET activates PTK2 signaling R-HSA-8874081 4.154885e-01 0.381 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.154885e-01 0.381 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.154885e-01 0.381 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.154885e-01 0.381 0 0
TRP channels R-HSA-3295583 4.154885e-01 0.381 0 0
Nucleotide Excision Repair R-HSA-5696398 4.183358e-01 0.378 0 0
Synthesis of DNA R-HSA-69239 4.338898e-01 0.363 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.386747e-01 0.358 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.386747e-01 0.358 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.386747e-01 0.358 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.386747e-01 0.358 0 0
Regulation of CDH11 function R-HSA-9762292 4.386747e-01 0.358 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.386747e-01 0.358 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.386747e-01 0.358 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.386747e-01 0.358 0 0
Pexophagy R-HSA-9664873 4.386747e-01 0.358 0 0
CASP4 inflammasome assembly R-HSA-9948001 4.386747e-01 0.358 0 0
Josephin domain DUBs R-HSA-5689877 4.386747e-01 0.358 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.434213e-01 0.353 0 0
Telomere Extension By Telomerase R-HSA-171319 4.455811e-01 0.351 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.455811e-01 0.351 0 0
Inflammasomes R-HSA-622312 4.455811e-01 0.351 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.455811e-01 0.351 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 4.542057e-01 0.343 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.556780e-01 0.341 0 0
TCR signaling R-HSA-202403 4.570779e-01 0.340 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.630733e-01 0.334 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.630733e-01 0.334 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.630733e-01 0.334 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.630733e-01 0.334 0 0
Signaling by APC mutants R-HSA-4839744 4.630733e-01 0.334 0 0
vRNP Assembly R-HSA-192905 4.630733e-01 0.334 0 0
vRNA Synthesis R-HSA-192814 4.630733e-01 0.334 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.630733e-01 0.334 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.630733e-01 0.334 0 0
Bicarbonate transporters R-HSA-425381 4.630733e-01 0.334 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.630733e-01 0.334 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.630733e-01 0.334 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.630733e-01 0.334 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.630733e-01 0.334 0 0
DNA Damage Bypass R-HSA-73893 4.643270e-01 0.333 0 0
DAP12 signaling R-HSA-2424491 4.747879e-01 0.324 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.747879e-01 0.324 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.747879e-01 0.324 0 0
Interleukin-37 signaling R-HSA-9008059 4.747879e-01 0.324 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.756132e-01 0.323 0 0
PI3K Cascade R-HSA-109704 4.756132e-01 0.323 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.864128e-01 0.313 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.864128e-01 0.313 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.864128e-01 0.313 0 0
NF-kB is activated and signals survival R-HSA-209560 4.864128e-01 0.313 0 0
ERKs are inactivated R-HSA-202670 4.864128e-01 0.313 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.864128e-01 0.313 0 0
Signaling by AXIN mutants R-HSA-4839735 4.864128e-01 0.313 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.864128e-01 0.313 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.864128e-01 0.313 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 4.864128e-01 0.313 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.864128e-01 0.313 0 0
Sodium/Calcium exchangers R-HSA-425561 4.864128e-01 0.313 0 0
Trafficking of AMPA receptors R-HSA-399719 4.890375e-01 0.311 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 4.890375e-01 0.311 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.937966e-01 0.306 0 0
Signaling by ERBB4 R-HSA-1236394 4.937966e-01 0.306 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.978472e-01 0.303 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.978472e-01 0.303 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.978472e-01 0.303 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.978472e-01 0.303 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.087390e-01 0.294 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.087390e-01 0.294 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.087390e-01 0.294 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.087390e-01 0.294 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.087390e-01 0.294 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.087390e-01 0.294 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.087390e-01 0.294 0 0
Repression of WNT target genes R-HSA-4641265 5.087390e-01 0.294 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.087390e-01 0.294 0 0
Signaling by LTK R-HSA-9842663 5.087390e-01 0.294 0 0
MET activates RAS signaling R-HSA-8851805 5.087390e-01 0.294 0 0
Leading Strand Synthesis R-HSA-69109 5.087390e-01 0.294 0 0
Polymerase switching R-HSA-69091 5.087390e-01 0.294 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.087390e-01 0.294 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.087390e-01 0.294 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.087390e-01 0.294 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.087390e-01 0.294 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.087390e-01 0.294 0 0
OAS antiviral response R-HSA-8983711 5.087390e-01 0.294 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.087844e-01 0.293 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.087844e-01 0.293 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.087844e-01 0.293 0 0
Nucleotide biosynthesis R-HSA-8956320 5.087844e-01 0.293 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.167959e-01 0.287 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.167959e-01 0.287 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.167959e-01 0.287 0 0
Nuclear RNA decay R-HSA-9930044 5.167959e-01 0.287 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.167959e-01 0.287 0 0
Cardiogenesis R-HSA-9733709 5.167959e-01 0.287 0 0
G-protein beta:gamma signalling R-HSA-397795 5.167959e-01 0.287 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.300961e-01 0.276 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 5.300961e-01 0.276 0 0
Formation of axial mesoderm R-HSA-9796292 5.300961e-01 0.276 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.300961e-01 0.276 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.300961e-01 0.276 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.300961e-01 0.276 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.300961e-01 0.276 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.302764e-01 0.275 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.302944e-01 0.275 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.302944e-01 0.275 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.314741e-01 0.275 0 0
FOXO-mediated transcription R-HSA-9614085 5.394987e-01 0.268 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.408231e-01 0.267 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.408231e-01 0.267 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.435338e-01 0.265 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.466803e-01 0.262 0 0
Parasite infection R-HSA-9664407 5.466803e-01 0.262 0 0
Leishmania phagocytosis R-HSA-9664417 5.466803e-01 0.262 0 0
Removal of the Flap Intermediate R-HSA-69166 5.505259e-01 0.259 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.505259e-01 0.259 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.505259e-01 0.259 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.505259e-01 0.259 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.505259e-01 0.259 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.505259e-01 0.259 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.505259e-01 0.259 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.505259e-01 0.259 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.505259e-01 0.259 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.505259e-01 0.259 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.505259e-01 0.259 0 0
HDL assembly R-HSA-8963896 5.505259e-01 0.259 0 0
PERK regulates gene expression R-HSA-381042 5.565110e-01 0.255 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.615003e-01 0.251 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.692240e-01 0.245 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.692240e-01 0.245 0 0
FLT3 signaling in disease R-HSA-9682385 5.692240e-01 0.245 0 0
RUNX2 regulates bone development R-HSA-8941326 5.692240e-01 0.245 0 0
Triglyceride catabolism R-HSA-163560 5.692240e-01 0.245 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.700686e-01 0.244 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.700686e-01 0.244 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 5.700686e-01 0.244 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.700686e-01 0.244 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.700686e-01 0.244 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.700686e-01 0.244 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.700686e-01 0.244 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.700686e-01 0.244 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.700686e-01 0.244 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.700686e-01 0.244 0 0
Extension of Telomeres R-HSA-180786 5.716248e-01 0.243 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.716248e-01 0.243 0 0
SLC transporter disorders R-HSA-5619102 5.774842e-01 0.238 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.887628e-01 0.230 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.887628e-01 0.230 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.887628e-01 0.230 0 0
Activation of SMO R-HSA-5635838 5.887628e-01 0.230 0 0
Attachment and Entry R-HSA-9678110 5.887628e-01 0.230 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.920024e-01 0.228 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.938512e-01 0.226 0 0
Extracellular matrix organization R-HSA-1474244 5.946211e-01 0.226 0 0
Mitochondrial protein import R-HSA-1268020 6.011123e-01 0.221 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.011123e-01 0.221 0 0
Heme signaling R-HSA-9707616 6.011123e-01 0.221 0 0
tRNA processing R-HSA-72306 6.013673e-01 0.221 0 0
Stabilization of p53 R-HSA-69541 6.057643e-01 0.218 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.066453e-01 0.217 0 0
Galactose catabolism R-HSA-70370 6.066453e-01 0.217 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.086142e-01 0.216 0 0
Stimuli-sensing channels R-HSA-2672351 6.159034e-01 0.210 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.174104e-01 0.209 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.174104e-01 0.209 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.174104e-01 0.209 0 0
Diseases of Immune System R-HSA-5260271 6.174104e-01 0.209 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.174104e-01 0.209 0 0
Glycogen metabolism R-HSA-8982491 6.174104e-01 0.209 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.174104e-01 0.209 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.237511e-01 0.205 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.237511e-01 0.205 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.237511e-01 0.205 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.237511e-01 0.205 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.237511e-01 0.205 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.237511e-01 0.205 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.237511e-01 0.205 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.287902e-01 0.201 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.287902e-01 0.201 0 0
FLT3 Signaling R-HSA-9607240 6.287902e-01 0.201 0 0
ER-Phagosome pathway R-HSA-1236974 6.327393e-01 0.199 0 0
Protein localization R-HSA-9609507 6.355396e-01 0.197 0 0
Adipogenesis R-HSA-9843745 6.358905e-01 0.197 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.399050e-01 0.194 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.401141e-01 0.194 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.401141e-01 0.194 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.401141e-01 0.194 0 0
PKA activation in glucagon signalling R-HSA-164378 6.401141e-01 0.194 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.401141e-01 0.194 0 0
Platelet sensitization by LDL R-HSA-432142 6.401141e-01 0.194 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.401141e-01 0.194 0 0
Apoptotic factor-mediated response R-HSA-111471 6.401141e-01 0.194 0 0
Tie2 Signaling R-HSA-210993 6.401141e-01 0.194 0 0
Mismatch Repair R-HSA-5358508 6.401141e-01 0.194 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.401141e-01 0.194 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.507561e-01 0.187 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.507561e-01 0.187 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.557664e-01 0.183 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.557664e-01 0.183 0 0
Pyrimidine biosynthesis R-HSA-500753 6.557664e-01 0.183 0 0
Translesion Synthesis by POLH R-HSA-110320 6.557664e-01 0.183 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.557664e-01 0.183 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.557664e-01 0.183 0 0
Specification of the neural plate border R-HSA-9834899 6.557664e-01 0.183 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.557664e-01 0.183 0 0
Signaling by Insulin receptor R-HSA-74752 6.633799e-01 0.178 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.647008e-01 0.177 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.707389e-01 0.173 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.707389e-01 0.173 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.707389e-01 0.173 0 0
Signaling by NODAL R-HSA-1181150 6.707389e-01 0.173 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.707389e-01 0.173 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.707389e-01 0.173 0 0
Negative regulation of MET activity R-HSA-6807004 6.707389e-01 0.173 0 0
Glycogen synthesis R-HSA-3322077 6.707389e-01 0.173 0 0
DAP12 interactions R-HSA-2172127 6.716755e-01 0.173 0 0
COPII-mediated vesicle transport R-HSA-204005 6.729844e-01 0.172 0 0
Integration of energy metabolism R-HSA-163685 6.732965e-01 0.172 0 0
Interferon alpha/beta signaling R-HSA-909733 6.778759e-01 0.169 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.812639e-01 0.167 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.812639e-01 0.167 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.812639e-01 0.167 0 0
Metabolism of cofactors R-HSA-8978934 6.812639e-01 0.167 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.817485e-01 0.166 0 0
Parasitic Infection Pathways R-HSA-9824443 6.849300e-01 0.164 0 0
Leishmania infection R-HSA-9658195 6.849300e-01 0.164 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.850610e-01 0.164 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.850610e-01 0.164 0 0
Lagging Strand Synthesis R-HSA-69186 6.850610e-01 0.164 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.850610e-01 0.164 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.850610e-01 0.164 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.850610e-01 0.164 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.850610e-01 0.164 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.850610e-01 0.164 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.915673e-01 0.160 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.915673e-01 0.160 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.915673e-01 0.160 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.915673e-01 0.160 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.915673e-01 0.160 0 0
Ca2+ pathway R-HSA-4086398 6.973529e-01 0.157 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.987609e-01 0.156 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.987609e-01 0.156 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.987609e-01 0.156 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.987609e-01 0.156 0 0
Attachment and Entry R-HSA-9694614 6.987609e-01 0.156 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.011351e-01 0.154 0 0
Ion channel transport R-HSA-983712 7.045710e-01 0.152 0 0
GPER1 signaling R-HSA-9634597 7.104550e-01 0.148 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.118657e-01 0.148 0 0
FGFR2 alternative splicing R-HSA-6803529 7.118657e-01 0.148 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.118657e-01 0.148 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.118657e-01 0.148 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.118657e-01 0.148 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.118657e-01 0.148 0 0
LDL clearance R-HSA-8964038 7.118657e-01 0.148 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.118657e-01 0.148 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.128190e-01 0.147 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.195305e-01 0.143 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.195305e-01 0.143 0 0
UCH proteinases R-HSA-5689603 7.203204e-01 0.142 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.244012e-01 0.140 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.244012e-01 0.140 0 0
Carnitine shuttle R-HSA-200425 7.244012e-01 0.140 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.244012e-01 0.140 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.276685e-01 0.138 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.363920e-01 0.133 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.363920e-01 0.133 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.363920e-01 0.133 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.363920e-01 0.133 0 0
Complex III assembly R-HSA-9865881 7.363920e-01 0.133 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.363920e-01 0.133 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.363920e-01 0.133 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.363920e-01 0.133 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.385410e-01 0.132 0 0
G1/S Transition R-HSA-69206 7.440469e-01 0.128 0 0
Orc1 removal from chromatin R-HSA-68949 7.453276e-01 0.128 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.453276e-01 0.128 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.478619e-01 0.126 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.478619e-01 0.126 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.478619e-01 0.126 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.478619e-01 0.126 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.478619e-01 0.126 0 0
HDMs demethylate histones R-HSA-3214842 7.478619e-01 0.126 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.478619e-01 0.126 0 0
Laminin interactions R-HSA-3000157 7.478619e-01 0.126 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.495325e-01 0.125 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.534630e-01 0.123 0 0
Metalloprotease DUBs R-HSA-5689901 7.588333e-01 0.120 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.588333e-01 0.120 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.588333e-01 0.120 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.588333e-01 0.120 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.588333e-01 0.120 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.588333e-01 0.120 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.588333e-01 0.120 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.588333e-01 0.120 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.613735e-01 0.118 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.652567e-01 0.116 0 0
Platelet homeostasis R-HSA-418346 7.680317e-01 0.115 0 0
G alpha (z) signalling events R-HSA-418597 7.690630e-01 0.114 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.693280e-01 0.114 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.693280e-01 0.114 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.693280e-01 0.114 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.693280e-01 0.114 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.693280e-01 0.114 0 0
Cristae formation R-HSA-8949613 7.693280e-01 0.114 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.693280e-01 0.114 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.693280e-01 0.114 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.693280e-01 0.114 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.791264e-01 0.108 0 0
HIV elongation arrest and recovery R-HSA-167287 7.793666e-01 0.108 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.793666e-01 0.108 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.793666e-01 0.108 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.793666e-01 0.108 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.793666e-01 0.108 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.793666e-01 0.108 0 0
Cardiac conduction R-HSA-5576891 7.806181e-01 0.108 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.871197e-01 0.104 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.889689e-01 0.103 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.889689e-01 0.103 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.889689e-01 0.103 0 0
Dual incision in TC-NER R-HSA-6782135 7.908490e-01 0.102 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.908490e-01 0.102 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 7.930113e-01 0.101 0 0
Triglyceride metabolism R-HSA-8979227 7.976979e-01 0.098 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.981538e-01 0.098 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.981538e-01 0.098 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.981538e-01 0.098 0 0
Pyruvate metabolism R-HSA-70268 7.987665e-01 0.098 0 0
tRNA Aminoacylation R-HSA-379724 8.043474e-01 0.095 0 0
Cargo concentration in the ER R-HSA-5694530 8.069395e-01 0.093 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.069395e-01 0.093 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.069395e-01 0.093 0 0
Downstream TCR signaling R-HSA-202424 8.152329e-01 0.089 0 0
Signaling by WNT in cancer R-HSA-4791275 8.153434e-01 0.089 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.153434e-01 0.089 0 0
G0 and Early G1 R-HSA-1538133 8.153434e-01 0.089 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.231436e-01 0.085 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.231436e-01 0.085 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.231436e-01 0.085 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.233819e-01 0.084 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.233819e-01 0.084 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.290394e-01 0.081 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.305426e-01 0.081 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.310709e-01 0.080 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.310709e-01 0.080 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.310709e-01 0.080 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.310709e-01 0.080 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.374671e-01 0.077 0 0
Signaling by NOTCH2 R-HSA-1980145 8.384256e-01 0.077 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.384256e-01 0.077 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.384256e-01 0.077 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.384256e-01 0.077 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.384256e-01 0.077 0 0
Signal amplification R-HSA-392518 8.384256e-01 0.077 0 0
Collagen formation R-HSA-1474290 8.401337e-01 0.076 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.454606e-01 0.073 0 0
Transcription of the HIV genome R-HSA-167172 8.508891e-01 0.070 0 0
Regulated Necrosis R-HSA-5218859 8.508891e-01 0.070 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.521897e-01 0.069 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.536395e-01 0.069 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.536395e-01 0.069 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.538536e-01 0.069 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.538536e-01 0.069 0 0
Voltage gated Potassium channels R-HSA-1296072 8.586261e-01 0.066 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.586261e-01 0.066 0 0
Collagen chain trimerization R-HSA-8948216 8.586261e-01 0.066 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.608329e-01 0.065 0 0
Regulation of insulin secretion R-HSA-422356 8.620806e-01 0.064 0 0
Elastic fibre formation R-HSA-1566948 8.647827e-01 0.063 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.647827e-01 0.063 0 0
Hedgehog 'on' state R-HSA-5632684 8.655739e-01 0.063 0 0
ABC-family proteins mediated transport R-HSA-382556 8.700914e-01 0.060 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.706715e-01 0.060 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.706715e-01 0.060 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.763042e-01 0.057 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.763042e-01 0.057 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.763042e-01 0.057 0 0
HIV Transcription Elongation R-HSA-167169 8.763042e-01 0.057 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.763042e-01 0.057 0 0
Interleukin-2 family signaling R-HSA-451927 8.763042e-01 0.057 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.816919e-01 0.055 0 0
Iron uptake and transport R-HSA-917937 8.830915e-01 0.054 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.830915e-01 0.054 0 0
HIV Transcription Initiation R-HSA-167161 8.868452e-01 0.052 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.868452e-01 0.052 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.868452e-01 0.052 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.868452e-01 0.052 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.868452e-01 0.052 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.868452e-01 0.052 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.868452e-01 0.052 0 0
Signaling by NOTCH1 R-HSA-1980143 8.871285e-01 0.052 0 0
RSV-host interactions R-HSA-9833110 8.883456e-01 0.051 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.905666e-01 0.050 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.917744e-01 0.050 0 0
Integrin cell surface interactions R-HSA-216083 8.948175e-01 0.048 0 0
PCP/CE pathway R-HSA-4086400 8.948175e-01 0.048 0 0
Interleukin-10 signaling R-HSA-6783783 8.948175e-01 0.048 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.964891e-01 0.047 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.964891e-01 0.047 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.984768e-01 0.046 0 0
Proteasome assembly R-HSA-9907900 9.009987e-01 0.045 0 0
Amine ligand-binding receptors R-HSA-375280 9.009987e-01 0.045 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.009987e-01 0.045 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.053121e-01 0.043 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.053121e-01 0.043 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.053121e-01 0.043 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.053121e-01 0.043 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.053121e-01 0.043 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.053121e-01 0.043 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.078688e-01 0.042 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.094379e-01 0.041 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.119588e-01 0.040 0 0
Synthesis of PC R-HSA-1483191 9.133841e-01 0.039 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.171586e-01 0.038 0 0
Metal ion SLC transporters R-HSA-425410 9.171586e-01 0.038 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.207688e-01 0.036 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.207688e-01 0.036 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.242219e-01 0.034 0 0
Azathioprine ADME R-HSA-9748787 9.242219e-01 0.034 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.275247e-01 0.033 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.275247e-01 0.033 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.306837e-01 0.031 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.337052e-01 0.030 0 0
Neurotransmitter release cycle R-HSA-112310 9.340390e-01 0.030 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.344423e-01 0.029 0 0
Visual phototransduction R-HSA-2187338 9.346922e-01 0.029 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.382464e-01 0.028 0 0
Gastrulation R-HSA-9758941 9.384036e-01 0.028 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.385230e-01 0.028 0 0
Paracetamol ADME R-HSA-9753281 9.393594e-01 0.027 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.420033e-01 0.026 0 0
FCGR activation R-HSA-2029481 9.430050e-01 0.025 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.430050e-01 0.025 0 0
Formation of the cornified envelope R-HSA-6809371 9.442056e-01 0.025 0 0
Mitochondrial protein degradation R-HSA-9837999 9.450584e-01 0.025 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.470413e-01 0.024 0 0
PPARA activates gene expression R-HSA-1989781 9.484158e-01 0.023 0 0
Peroxisomal protein import R-HSA-9033241 9.492639e-01 0.023 0 0
Regulation of beta-cell development R-HSA-186712 9.492639e-01 0.023 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.514069e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.514765e-01 0.022 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.514765e-01 0.022 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.514765e-01 0.022 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.514765e-01 0.022 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.514765e-01 0.022 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.514765e-01 0.022 0 0
Aquaporin-mediated transport R-HSA-445717 9.535927e-01 0.021 0 0
Collagen degradation R-HSA-1442490 9.535927e-01 0.021 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.556167e-01 0.020 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.559743e-01 0.020 0 0
Complex I biogenesis R-HSA-6799198 9.575526e-01 0.019 0 0
Circadian clock R-HSA-9909396 9.598122e-01 0.018 0 0
PI Metabolism R-HSA-1483255 9.606219e-01 0.017 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.644887e-01 0.016 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.660381e-01 0.015 0 0
G alpha (q) signalling events R-HSA-416476 9.686280e-01 0.014 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.687563e-01 0.014 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.689372e-01 0.014 0 0
ECM proteoglycans R-HSA-3000178 9.702927e-01 0.013 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.702927e-01 0.013 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.715892e-01 0.013 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.719075e-01 0.012 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.728292e-01 0.012 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.739535e-01 0.011 0 0
ABC transporter disorders R-HSA-5619084 9.782638e-01 0.010 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.782638e-01 0.010 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.784586e-01 0.009 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.784586e-01 0.009 0 0
Interleukin-1 family signaling R-HSA-446652 9.809193e-01 0.008 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.833720e-01 0.007 0 0
Interferon gamma signaling R-HSA-877300 9.850331e-01 0.007 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.859887e-01 0.006 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.896361e-01 0.005 0 0
Mitochondrial translation elongation R-HSA-5389840 9.914927e-01 0.004 0 0
Potassium Channels R-HSA-1296071 9.914927e-01 0.004 0 0
G alpha (i) signalling events R-HSA-418594 9.918139e-01 0.004 1 0
Mitochondrial translation initiation R-HSA-5368286 9.922203e-01 0.003 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.924413e-01 0.003 0 0
Interleukin-1 signaling R-HSA-9020702 9.931968e-01 0.003 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.932104e-01 0.003 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.937788e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.940080e-01 0.003 0 0
Neddylation R-HSA-8951664 9.941085e-01 0.003 0 0
Bacterial Infection Pathways R-HSA-9824439 9.943767e-01 0.002 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.952714e-01 0.002 0 0
Mitochondrial translation termination R-HSA-5419276 9.954512e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.968810e-01 0.001 1 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.973932e-01 0.001 0 0
Keratinization R-HSA-6805567 9.974313e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.980331e-01 0.001 0 0
Diseases of glycosylation R-HSA-3781865 9.988355e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.989261e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.990078e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.991638e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.994624e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.994937e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.995283e-01 0.000 1 0
Phospholipid metabolism R-HSA-1483257 9.995607e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998484e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998494e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999195e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999465e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999511e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999762e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999915e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999945e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999984e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999985e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999986e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999991e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999996e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways