IRAK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
B2RPK0 S15 Sugiyama HMGB1P1 HMG1L1 HMGB1L1 ______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHSDAS
O00151 S130 Sugiyama PDLIM1 CLIM1 CLP36 PQEVLHIGsAHNRsAMPFtAsPAsSTTARVItNQyNNPAGL
O00151 S31 Sugiyama PDLIM1 CLIM1 CLP36 PGPWGFRLVGGKDFEQPLAIsRVtPGSKAALANLCIGDVIT
O00571 S82 Sugiyama DDX3X DBX DDX3 ssKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRs
O14910 S135 Sugiyama LIN7A MALS1 VELI1 DEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGDQL
O14950 T160 Sugiyama MYL12B MRLC2 MYLC2B DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O14979 T165 Sugiyama HNRNPDL HNRPDL JKTBP QDDGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVT
O15143 S330 Sugiyama ARPC1B ARC41 ssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTTGM
O15371 T46 Sugiyama EIF3D EIF3S7 RDMPyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGG
O43290 S670 Sugiyama SART1 LLETTVQKVARVKAPNKSLPsAVyCIEDKMAIDDKYSRREE
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O60739 T45 Sugiyama EIF1B AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
O60739 T46 Sugiyama EIF1B GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
O60749 S119 Sugiyama SNX2 TRG9 AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60828 T219 Sugiyama PQBP1 NPW38 JM26 EELDPMDPSsysDAPRGTWstGLPKRNEAKTGADttAAGPL
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 T289 Sugiyama EIF5B IF2 KIAA0741 QKESQRKFEEETVKSKVTVDtGVIPAsEEKAEtPtAAEDDN
O60925 S78 Sugiyama PFDN1 PFD1 TNMYEGVGRMFILQSKEAIHsQLLEKQKIAEEKIKELEQKK
O75534 S766 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR AAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDNsMGFG
O75643 S17 Sugiyama SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788 ____MADVTARsLQYEYKANsNLVLQADRsLIDRTRRDEPT
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O76070 S92 Sugiyama SNCG BCSG1 PERSYN PRSN ssVNTVATKTVEEAENIAVtsGVVRKEDLRPSAPQQEGEAs
O76070 T91 Sugiyama SNCG BCSG1 PERSYN PRSN VssVNTVATKTVEEAENIAVtsGVVRKEDLRPSAPQQEGEA
O94992 S268 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 EDGGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELI
O94992 T270 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95218 S65 Sugiyama ZRANB2 ZIS ZNF265 MKAGGtEIGKtLAEKSRGLFsANDWQCKTCsNVNWARRsEC
O95259 S952 Sugiyama KCNH1 EAG EAG1 ELKEDIKALNAKMTNIEKQLsEILRILTSRRSSQSPQELFE
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T52 Sugiyama ALDOA ALDA AADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDRVNP
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792 S176 Sugiyama HSPB1 HSP27 HSP28 sLsPEGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGPEA
P04792 S187 Sugiyama HSPB1 HSP27 HSP28 APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P04792 T91 Sugiyama HSPB1 HSP27 HSP28 PAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAPDELtV
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 T19 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 __MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06748 S137 Sugiyama NPM1 NPM VAVEEDAEsEDEEEEDVKLLsIsGKRsAPGGGsKVPQKKVK
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S439 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB NIVIAKMDstANEVEAVKVHsFPtLKFFPAsADRtVIDyNG
P07237 T442 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB IAKMDstANEVEAVKVHsFPtLKFFPAsADRtVIDyNGERt
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758 T111 Sugiyama ANXA5 ANX5 ENX2 PP4 yDAyELKHALKGAGTNEKVLtEIIAsRtPEELRAIKQVyEE
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09429 S15 Sugiyama HMGB1 HMG1 ______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHPDAs
P09661 S226 Sugiyama SNRPA1 NAIANAstLAEVERLKGLLQsGQIPGRERRsGPtDDGEEEM
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11388 S1449 Sugiyama TOP2A TOP2 TTGAKKRAAPKGTKRDPALNsGVsQKPDPAKTKNRRKRKPs
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13073 S71 Sugiyama COX4I1 COX4 HVKHLSASQKALKEKEKASWssLsMDEKVELYRIKFKEsFA
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13984 T16 Sugiyama GTF2F2 RAP30 _____MAERGELDLTGAKQNtGVWLVKVPKYLsQQWAKASG
P14314 S108 Sugiyama PRKCSH G19P1 PSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQ
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314 S478 Sugiyama PRKCSH G19P1 DKFSAMKyEQGtGCWQGPNRstTVRLLCGKEtMVtStTEPS
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14649 S87 Sugiyama MYL6B MLC1SA EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880 S281 Sugiyama RPS2 RPS4 FtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt________
P15880 T276 Sugiyama RPS2 RPS4 WKEtVFtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt___
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P19105 T159 Sugiyama MYL12A MLCB MRLC3 RLC DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20674 T105 Sugiyama COX5A EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY
P20810 S337 Sugiyama CAST EAKAKEEKLEKCGEDDEtIPsEyRLKPATDKDGKPLLPEPE
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25398 S107 Sugiyama RPS12 EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26583 S15 Sugiyama HMGB2 HMG2 ______MGKGDPNKPRGKMssyAFFVQtCREEHKKKHPDss
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27695 S129 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 QELPGLSHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDE
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816 T828 Sugiyama MAP4 AKtttAAAVAstGPssRsPstLLPKKPTAIKTEGKPAEVKK
P29401 T442 Sugiyama TKT GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 T129 Sugiyama EEF1D EF1D EARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPA
P30041 T48 Sugiyama PRDX6 AOP2 KIAA0106 FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30044 S168 Sugiyama PRDX5 ACR1 SBBI10 RLLADPTGAFGKEtDLLLDDsLVsIFGNRRLKRFsMVVQDG
P30086 T44 Sugiyama PEBP1 PBP PEBP PLHVTYAGAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLy
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P30622 T27 Sugiyama CLIP1 CYLN1 RSN SGLKAPtKILKPGsTALKtPtAVVAPVEKtISSEKAsstPs
P31939 S401 Sugiyama ATIC PURH OK/SW-cl.86 LFGLHLsQKRNNGVVDKSLFsNVVTKNKDLPESALRDLIVA
P31943 S269 Sugiyama HNRNPH1 HNRPH HNRPH1 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P33316 S164 Sugiyama DUT YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35579 S1892 Sugiyama MYH9 LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35579 T1745 Sugiyama MYH9 RRLEARIAQLEEELEEEQGNtELINDRLKKANLQIDQINtD
P35579 T1764 Sugiyama MYH9 NtELINDRLKKANLQIDQINtDLNLERSHAQKNENARQQLE
P35637 S360 Sugiyama FUS TLS sFDDPPsAKAAIDWFDGKEFsGNPIKVsFATRRADFNRGGG
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802 S11 Sugiyama TAGLN2 KIAA0120 CDABP0035 __________MANRGPAyGLsREVQQKIEKQyDADLEQILI
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646 S212 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P40763 S727 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP STAT3 APRF KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P40925 S153 Sugiyama MDH1 MDHA ANtNCLtAsKSAPSIPKENFsCLtRLDHNRAKAQIALKLGV
P41236 S24 Sugiyama PPP1R2 IPP2 STAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSKKs
P41567 T45 Sugiyama EIF1 SUI1 AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
P41567 T46 Sugiyama EIF1 SUI1 GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
P46013 S1686 Sugiyama MKI67 PTGDGKSMKAFMEsPKQILDsAAsLtGsKRQLRTPKGKsEV
P46087 T26 Sugiyama NOP2 NOL1 NSUN1 DPTKEKRGPGRKARKQKGAEtELVRFLPAVsDENsKRLsSR
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776 S83 Sugiyama RPL27A LKRNQsFCPtVNLDKLWtLVsEQtRVNAAKNKtGAAPIIDV
P46776 T80 Sugiyama RPL27A HYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAKNKtGAAPI
P47224 S39 Sugiyama RABIF MSS4 RASGRF3 KAVLCQRCGSRVLQPGtALFsRRQLFLPSMRKKPALSDGSN
P47224 T35 Sugiyama RABIF MSS4 RASGRF3 GRNRKAVLCQRCGSRVLQPGtALFsRRQLFLPSMRKKPALS
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S662 Sugiyama NASP LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49736 S26 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 EsFtMAssPAQRRRGNDPLtssPGRssRRtDALtssPGRDL
P49790 S1456 Sugiyama NUP153 FPFNQSPAAFTVGSNGKNVFsssGtsFsGRKIKTAVRRRK_
P49790 S1461 Sugiyama NUP153 SPAAFTVGSNGKNVFsssGtsFsGRKIKTAVRRRK______
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P51617 S213 Sugiyama IRAK1 IRAK ARPFPFCWPLCEISRGtHNFsEELKIGEGGFGCVYRAVMRN
P51617 S264 Sugiyama IRAK1 IRAK NADLEWtAVKQSFLTEVEQLsRFRHPNIVDFAGYCAQNGFY
P51617 S344 Sugiyama IRAK1 IRAK RAIQFLHQDSPSLIHGDIKSsNVLLDERLTPKLGDFGLARF
P51617 S371 Sugiyama IRAK1 IRAK RLTPKLGDFGLARFSRFAGssPsQssMVARTQTVRGtLAyL
P51617 S375 Sugiyama IRAK1 IRAK KLGDFGLARFSRFAGssPsQssMVARTQTVRGtLAyLPEEy
P51617 S376 SIGNOR|iPTMNet|EPSD|Sugiyama IRAK1 IRAK LGDFGLARFSRFAGssPsQssMVARTQTVRGtLAyLPEEyI
P51617 S556 Sugiyama IRAK1 IRAK SCIPPSPQENSYVSSTGRAHsGAAPWQPLAAPsGAsAQAAE
P51617 S568 Sugiyama IRAK1 IRAK VSSTGRAHsGAAPWQPLAAPsGAsAQAAEQLQRGPNQPVEs
P51617 S571 Sugiyama IRAK1 IRAK TGRAHsGAAPWQPLAAPsGAsAQAAEQLQRGPNQPVEsDEs
P51617 S588 Sugiyama IRAK1 IRAK sGAsAQAAEQLQRGPNQPVEsDEsLGGLsAALRsWHLtPsC
P51617 S591 Sugiyama IRAK1 IRAK sAQAAEQLQRGPNQPVEsDEsLGGLsAALRsWHLtPsCPLD
P51617 S596 Sugiyama IRAK1 IRAK EQLQRGPNQPVEsDEsLGGLsAALRsWHLtPsCPLDPAPLR
P51617 S607 Sugiyama IRAK1 IRAK EsDEsLGGLsAALRsWHLtPsCPLDPAPLREAGCPQGDTAG
P51617 T209 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP IRAK1 IRAK LLQGARPFPFCWPLCEISRGtHNFsEELKIGEGGFGCVYRA
P51617 T250 Sugiyama IRAK1 IRAK VMRNTVYAVKRLKENADLEWtAVKQSFLTEVEQLsRFRHPN
P51617 T322 Sugiyama IRAK1 IRAK CQTQACPPLSWPQRLDILLGtARAIQFLHQDSPSLIHGDIK
P51617 T387 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama IRAK1 IRAK FAGssPsQssMVARTQTVRGtLAyLPEEyIKtGRLAVDTDT
P51617 T398 Sugiyama IRAK1 IRAK VARTQTVRGtLAyLPEEyIKtGRLAVDTDTFSFGVVVLETL
P51617 T605 Sugiyama IRAK1 IRAK PVEsDEsLGGLsAALRsWHLtPsCPLDPAPLREAGCPQGDT
P51617 T66 SIGNOR|iPTMNet|EPSD IRAK1 IRAK AALIVRDQTELRLCERSGQRtASVLWPWINRNARVADLVHI
P51617 Y390 Sugiyama IRAK1 IRAK ssPsQssMVARTQTVRGtLAyLPEEyIKtGRLAVDTDTFSF
P51617 Y395 Sugiyama IRAK1 IRAK ssMVARTQTVRGtLAyLPEEyIKtGRLAVDTDTFSFGVVVL
P52948 S872 Sugiyama NUP98 ADAR2 LEAVSRKQGAQFKEyRPEtGsWVFKVSHFSKYGLQDsDEEE
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55072 T14 Sugiyama VCP HEL-220 HEL-S-70 _______MAsGADsKGDDLstAILKQKNRPNRLIVDEAINE
P55795 S269 Sugiyama HNRNPH2 FTP3 HNRPH2 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 S97 Sugiyama TPI1 TPI GEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELIGQKVAHA
P60174 T205 Sugiyama TPI1 TPI VHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQP
P60174 T214 Sugiyama TPI1 TPI KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174 T76 Sugiyama TPI1 TPI LDPKIAVAAQNCyKVTNGAFtGEIsPGMIKDCGAtWVVLGH
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60228 S442 Sugiyama EIF3E EIF3S6 INT6 IEKKLNQNSRSEAPNWAtQDsGFy_________________
P60660 S30 Sugiyama MYL6 AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61604 S21 Sugiyama HSPE1 MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61604 S64 Sugiyama HSPE1 AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD
P61604 T45 Sugiyama HSPE1 TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P61769 S108 Sugiyama B2M CDABP0092 HDCMA22P TEFTPTEKDEYACRVNHVtLsQPKIVKWDRDM_________
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62081 S174 Sugiyama RPS7 IKVHLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 S9 Sugiyama RPS29 ____________MGHQQLyWsHPRKFGQGSRSCRVCSNRHG
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62312 S74 Sugiyama LSM6 GQLKNKyGDAFIRGNNVLyIstQKRRM______________
P62316 T40 Sugiyama SNRPD2 SNRPD1 EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62316 T75 Sugiyama SNRPD2 SNRPD1 RVKAFDRHCNMVLENVKEMWtEVPKSGKGKKKSKPVNKDRY
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62633 S121 Sugiyama CNBP RNF163 ZNF9 CGKPGHLARDCDHADEQKCysCGEFGHIQKDCTKVKCYRCG
P62633 Y120 Sugiyama CNBP RNF163 ZNF9 NCGKPGHLARDCDHADEQKCysCGEFGHIQKDCTKVKCYRC
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62857 S39 Sugiyama RPS28 GRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLL
P62857 S41 Sugiyama RPS28 tGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLLEs
P62857 T28 Sugiyama RPS28 PIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsIIRNVKG
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T22 Sugiyama RPL31 APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62899 Y25 Sugiyama RPL31 KKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRA
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942 T28 Sugiyama FKBP1A FKBP1 FKBP12 IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S31 Sugiyama RPS21 LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 T89 Sugiyama YBX1 NSEP1 YB1 RNGyGFINRNDtKEDVFVHQtAIKKNNPRKyLRsVGDGEtV
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 S9 Sugiyama RPL24 ____________MKVELCsFsGyKIYPGHGRRYARTDGKVF
P83731 T52 Sugiyama RPL24 LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P98179 S120 Sugiyama RBM3 RNPL GRSYSRGGGDQGYGSGRyyDsRPGGyGyGyGRSRDYNGRNQ
Q00688 T11 Sugiyama FKBP3 FKBP25 __________MAAAVPQRAWtVEQLRSEQLPKKDIIKFLQE
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02878 S255 Sugiyama RPL6 TXREB1 tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q04837 S67 Sugiyama SSBP1 SSBP QVEGKNPVTIFSLATNEMWRsGDsEVyQLGDVsQKTTWHRI
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q05682 T169 Sugiyama CALD1 CAD CDM KEEKsESRQERyEIEETEtVtKSYQKNDWRDAEENKKEDKE
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q13263 S784 Sugiyama TRIM28 KAP1 RNF96 TIF1B DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13428 T1010 Sugiyama TCOF1 SESTARssssEsEDEDVIPAtQCLtPGIRTNVVTMPTAHPR
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13442 Y17 Sugiyama PDAP1 HASPP28 ____MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREE
Q13492 S565 Sugiyama PICALM CALM ANLVGNLGIGNGTTKNDVNWsQPGEKKLtGGSNWQPKVAPT
Q13573 S182 Sugiyama SNW1 SKIIP SKIP AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q13601 S284 Sugiyama KRR1 HRB2 KEYtPFPPPQPESQIDKELAsGEyFLKANQKKRQKMEAIKA
Q13765 S186 Sugiyama NACA HSD48 sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q13765 S191 Sugiyama NACA HSD48 VDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDIVNAIM
Q14151 S613 Sugiyama SAFB2 KIAA0138 ERSSKSQDRKSESKEKRDILsFDKIKEQRERERQRQREREI
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 S907 Sugiyama EIF3A EIF3S10 KIAA0139 DSRWGDRDsEGtWRKGPEADsEWRRGPPEKEWRRGEGRDED
Q14152 T1378 Sugiyama EIF3A EIF3S10 KIAA0139 AEKDREsLRRTKNEtDEDGWttVRR________________
Q14157 S859 Sugiyama UBAP2L KIAA0144 NICE4 FPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATTL
Q14157 T241 Sugiyama UBAP2L KIAA0144 NICE4 TWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtA
Q14157 T256 Sugiyama UBAP2L KIAA0144 NICE4 AWRtAtEEWGtEDWNEDLsEtKIFtAsNVssVPLPAENVtI
Q14192 S257 Sugiyama FHL2 DRAL SLIM3 IsFEERQWHNDCFNCKKCsLsLVGRGFLTERDDILCPDCGK
Q14247 S135 Sugiyama CTTN EMS1 VDsVRGFGGKFGVQMDRVDQsAVGFEyQGKtEKHAsQKDys
Q14247 S331 Sugiyama CTTN EMS1 GVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIR
Q14247 S332 Sugiyama CTTN EMS1 VQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRA
Q14247 T347 Sugiyama CTTN EMS1 VtQVssAyQKTVPVEAVtsKtsNIRANFENLAKEKEQEDRR
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14847 T63 Sugiyama LASP1 MLN50 NYKGYEKKPYCNAHyPKQsFtMVADtPENLRLKQQSELQsQ
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15056 S13 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 ________MADFDtyDDRAyssFGGGRGsRGsAGGHGsRSQ
Q15293 T101 Sugiyama RCN1 RCN KERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNVA
Q15417 S259 Sugiyama CNN3 DNSTISLQMGTNKVAsQKGMsVyGLGRQVYDPKYCAAPTEP
Q15648 S1493 Sugiyama MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2 EKsyQNsPssDDGIRPLPEYstEKHKKHKKEKKKVKDKDRD
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q5M775 S112 Sugiyama SPECC1 CYTSB NSP5 SGTGAFTTTKRTGIPAPREFsVTVSRERsVPRGPSNPRKsV
Q5SW79 S871 Sugiyama CEP170 FAM68A KAB KIAA0470 ELIPHINKQTsstPssLALtsAsRIRERsEsLDPDssMDTt
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q66K64 T184 Sugiyama DCAF15 C19orf72 GMLMNMMMMSDENHRDIyVStVAVPPPGRCAACQDASRAHP
Q66K64 Y181 Sugiyama DCAF15 C19orf72 SANGMLMNMMMMSDENHRDIyVStVAVPPPGRCAACQDASR
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6FI81 S305 Sugiyama CIAPIN1 CUA001 PRO0915 CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6QNY0 S129 Sugiyama BLOC1S3 BLOS3 LQLRLAESQARLDHDVAAAVsGVYRRAGRDVAALASRLAAA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q7LBC6 S766 Sugiyama KDM3B C5orf7 JHDM2B JMJD1B KIAA1082 tEERPtVGPGQQDNPLLKTFsNVFGRHsGGFLssPADFsQE
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z2W4 T363 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 NPGstyLASNsTsAPNWKsLtsWtNDQGARRKtVFsPtLPA
Q7Z2W4 T366 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 styLASNsTsAPNWKsLtsWtNDQGARRKtVFsPtLPAARs
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417 S671 Sugiyama NUFIP2 KIAA1321 PIG1 DsWGsFDLRAAIVYHTKEMEsIWNLQKQDPKRIItyNEAMD
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V81 S142 Sugiyama ALYREF ALY BEF THOC4 IQELFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKA
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86WR0 S187 Sugiyama CCDC25 KKREKEEMKKKREMDELRSYssLMKVENMSSNQDGNDsDEF
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N6T3 S348 Sugiyama ARFGAP1 ARF1GAP FWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWG
Q8N6T3 T291 Sugiyama ARFGAP1 ARF1GAP GVsQLAsKVQGVGSKGWRDVttFFsGKAEGPLDsPSEGHSy
Q8N6T3 T350 Sugiyama ARFGAP1 ARF1GAP ETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWGSA
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TDD1 S587 Sugiyama DDX54 KNYRSRATIFEINAsSRDLCsQVMRAKRQKDRKAIARFQQG
Q8TEW0 S210 Sugiyama PARD3 PAR3 PAR3A TCDRKKDENYRsLPRDTSNWsNQFQRDNARssLsAsHPMVG
Q92841 S601 Sugiyama DDX17 QDECDRRLRGVKDGGRRDsAsYRDRSETDRAGYANGSGYGS
Q92900 S1110 Sugiyama UPF1 KIAA0221 RENT1 QDSYLGDEFKsQIDVALsQDstyQGERAyQHGGVtGLsQy_
Q96C01 S135 Sugiyama FAM136A VDDHMHLIPTMTKKMKEALLsIGK_________________
Q96FA3 S125 EPSD|PSP PELI1 PRISM STESPIDFVVTDTVPGSQSNsDtQSVQSTISRFACRIICER
Q96FA3 S293 SIGNOR|EPSD|PSP PELI1 PRISM QEINAARPQCPVGFNtLAFPsMKRKDVVDEKQPWVYLNCGH
Q96FA3 S70 EPSD|PSP PELI1 PRISM NGVKPSTVHIACTPQAAKAIsNKDQHsIsYtLsRAQtVVVE
Q96FA3 S76 SIGNOR|EPSD|PSP PELI1 PRISM TVHIACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSN
Q96FA3 S78 SIGNOR|EPSD|PSP PELI1 PRISM HIACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTD
Q96FA3 S82 SIGNOR|EPSD|PSP PELI1 PRISM TPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTDMFQI
Q96FA3 T127 EPSD|PSP PELI1 PRISM ESPIDFVVTDTVPGSQSNsDtQSVQSTISRFACRIICERNP
Q96FA3 T288 SIGNOR|EPSD|PSP PELI1 PRISM LEALRQEINAARPQCPVGFNtLAFPsMKRKDVVDEKQPWVY
Q96FA3 T80 SIGNOR|EPSD|PSP PELI1 PRISM ACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTDMF
Q96FA3 T86 SIGNOR|EPSD|PSP PELI1 PRISM AKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTDMFQIGRST
Q96MH2 S194 Sugiyama HEXIM2 L3 EAGDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELV
Q96MH2 T196 Sugiyama HEXIM2 L3 GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q96PK6 S520 Sugiyama RBM14 SIP AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q99439 S217 Sugiyama CNN2 ILPPMDHSTISLQMGTNKCAsQVGMTAPGTRRHIyDTKLGT
Q99519 T89 Sugiyama NEU1 NANH RQIGSVDTFRIPLITATPRGtLLAFAEARKMSSSDEGAKFI
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BX68 S57 Sugiyama HINT2 GNEVAKAQQAtPGGAAPtIFsRILDKsLPADILyEDQQCLV
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H444 T101 Sugiyama CHMP4B C20orf178 SHAX1 QIDGtLstIEFQREALENANtNtEVLKNMGYAAKAMKAAHD
Q9H4G4 S58 SIGNOR GLIPR2 C9orf19 GAPR1 EAQQYSEALASTRILKHsPEssRGQCGENLAWASYDQTGKE
Q9HAP6 S120 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 DEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGDQL
Q9HAT8 T290 EPSD|PSP PELI2 IEALRQEINAARPQCPVGLNtLAFPsINRKEVVEEKQPWAY
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NUP9 S120 Sugiyama LIN7C MALS3 VELI3 EEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGDQL
Q9NVS9 T111 Sugiyama PNPO KPSARMLLLKGFGKDGFRFFtNFESRKGKELDSNPFASLVF
Q9NYF8 S319 Sugiyama BCLAF1 BTF KIAA0164 RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9NZB2 S990 Sugiyama FAM120A C9orf10 KIAA0183 OSSA FPLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKN
Q9NZZ3 S16 Sugiyama CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 _____MNRLFGKAKPKAPPPsLtDCIGtVDsRAEsIDKKIS
Q9UGU0 S1187 Sugiyama TCF20 KIAA0292 SPBP sDGLPNKGMELKHGSQKLQEsCWDLsRQTsPAKSSGPPGMS
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UMX5 T130 Sugiyama NENF CIR2 SPUF LTHDTTGLTAKELEALDEVFtKVYKAKYPIVGYTARRILNE
Q9UNF1 T92 Sugiyama MAGED2 BCG1 tPEAREAPAtQAssttQLtDtQVLAAENKSLAADTKKQNAD
Q9UNZ2 S192 Sugiyama NSFL1C UBXN2C KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UQ35 S2459 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 LLPPAQDQPRsPVPsAFsDQsRCLIAQTTPVAGSQSLSSGA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 T124 Sugiyama YBX2 CSDA3 MSY2 RNGyGFINRNDtKEDVFVHQtAIKRNNPRKFLRsVGDGEtV
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2V2 S52 Sugiyama CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y6W5 S442 Sugiyama WASF2 WAVE2 DTTKPKSSLPAVSDARSDLLsAIRQGFQLRRVEEQREQEKR
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.609823e-14 13.793 0 0
Cell Cycle, Mitotic R-HSA-69278 1.138312e-12 11.944 0 0
Signal Transduction R-HSA-162582 5.459755e-11 10.263 1 0
Cell Cycle Checkpoints R-HSA-69620 1.531280e-10 9.815 0 0
Axon guidance R-HSA-422475 3.339244e-10 9.476 0 0
M Phase R-HSA-68886 1.278410e-09 8.893 0 0
Recycling pathway of L1 R-HSA-437239 1.823007e-09 8.739 0 0
Nervous system development R-HSA-9675108 2.127396e-09 8.672 0 0
Cellular responses to stimuli R-HSA-8953897 8.887400e-09 8.051 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.189380e-08 7.925 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.653973e-08 7.781 0 0
Mitotic Prometaphase R-HSA-68877 2.244039e-08 7.649 0 0
Cellular responses to stress R-HSA-2262752 2.763199e-08 7.559 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.959241e-08 7.529 0 0
Cellular Senescence R-HSA-2559583 3.515240e-08 7.454 0 0
Post NMDA receptor activation events R-HSA-438064 5.818472e-08 7.235 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.567198e-07 6.805 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.538500e-07 6.813 0 0
L1CAM interactions R-HSA-373760 2.582212e-07 6.588 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.681800e-07 6.330 0 0
Selective autophagy R-HSA-9663891 4.941588e-07 6.306 0 0
G2/M Checkpoints R-HSA-69481 6.986719e-07 6.156 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.716385e-07 6.113 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.716385e-07 6.113 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.702559e-07 6.013 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.655500e-06 5.781 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.255313e-06 5.647 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.237357e-06 5.650 0 0
Diseases of programmed cell death R-HSA-9645723 2.885781e-06 5.540 0 0
Aggrephagy R-HSA-9646399 3.324703e-06 5.478 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.416819e-06 5.466 0 0
Separation of Sister Chromatids R-HSA-2467813 3.720681e-06 5.429 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.475617e-06 5.349 0 0
Signaling by VEGF R-HSA-194138 4.508053e-06 5.346 0 0
G2/M Transition R-HSA-69275 5.851525e-06 5.233 0 0
Membrane Trafficking R-HSA-199991 7.751554e-06 5.111 0 0
Mitotic Anaphase R-HSA-68882 1.416762e-05 4.849 0 0
Regulation of TP53 Activity R-HSA-5633007 1.373372e-05 4.862 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.651309e-05 4.782 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.620876e-05 4.790 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.896454e-05 4.722 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.216832e-05 4.654 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.422273e-05 4.616 0 0
Generic Transcription Pathway R-HSA-212436 2.380448e-05 4.623 1 0
Signaling by Interleukins R-HSA-449147 2.428995e-05 4.615 1 0
Processing of DNA double-strand break ends R-HSA-5693607 3.001124e-05 4.523 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.128479e-05 4.505 0 0
Apoptotic execution phase R-HSA-75153 3.248710e-05 4.488 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.397565e-05 4.469 0 0
Kinesins R-HSA-983189 3.470458e-05 4.460 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.603950e-05 4.443 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.603950e-05 4.443 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.969157e-05 4.401 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.969157e-05 4.401 0 0
EPH-Ephrin signaling R-HSA-2682334 4.373722e-05 4.359 0 0
Interleukin-37 signaling R-HSA-9008059 5.209284e-05 4.283 0 0
Neurodegenerative Diseases R-HSA-8863678 5.426257e-05 4.265 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.426257e-05 4.265 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.947988e-05 4.226 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.947988e-05 4.226 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.842203e-05 4.165 0 0
Signaling by Hippo R-HSA-2028269 7.306578e-05 4.136 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.784211e-05 4.109 0 0
Muscle contraction R-HSA-397014 7.606438e-05 4.119 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.840749e-05 4.106 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.620169e-05 4.064 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.010108e-04 3.996 0 0
RNA Polymerase II Transcription R-HSA-73857 1.025258e-04 3.989 1 0
DNA Double-Strand Break Repair R-HSA-5693532 1.043728e-04 3.981 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.161155e-04 3.935 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.230978e-04 3.910 0 0
Gene expression (Transcription) R-HSA-74160 1.247776e-04 3.904 1 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.441134e-04 3.841 0 0
Homology Directed Repair R-HSA-5693538 1.403480e-04 3.853 0 0
Autophagy R-HSA-9612973 1.588904e-04 3.799 0 0
Cell-Cell communication R-HSA-1500931 1.629770e-04 3.788 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.233557e-04 3.651 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.303524e-04 3.638 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.322112e-04 3.634 0 0
Signaling by ALK in cancer R-HSA-9700206 2.322112e-04 3.634 0 0
DNA methylation R-HSA-5334118 3.240999e-04 3.489 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.240999e-04 3.489 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.125615e-04 3.505 0 0
Meiosis R-HSA-1500620 3.125615e-04 3.505 0 0
Cell junction organization R-HSA-446728 3.242814e-04 3.489 0 0
Apoptosis R-HSA-109581 3.514092e-04 3.454 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.572172e-04 3.447 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.717000e-04 3.430 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.757689e-04 3.425 0 0
Nucleosome assembly R-HSA-774815 4.089801e-04 3.388 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.089801e-04 3.388 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.121397e-04 3.385 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.990902e-04 3.399 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.432995e-04 3.353 0 0
Gap junction trafficking and regulation R-HSA-157858 4.498998e-04 3.347 0 0
Packaging Of Telomere Ends R-HSA-171306 4.869922e-04 3.312 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.869922e-04 3.312 0 0
Meiotic synapsis R-HSA-1221632 4.866646e-04 3.313 0 0
Deubiquitination R-HSA-5688426 4.803332e-04 3.318 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.184891e-04 3.285 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.259451e-04 3.279 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.301326e-04 3.276 0 0
Striated Muscle Contraction R-HSA-390522 5.328921e-04 3.273 0 0
Macroautophagy R-HSA-1632852 5.550713e-04 3.256 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.676344e-04 3.246 0 0
Mitotic Prophase R-HSA-68875 6.574351e-04 3.182 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.715745e-04 3.173 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.036975e-04 3.153 0 0
Meiotic recombination R-HSA-912446 7.102011e-04 3.149 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.472598e-04 3.127 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.593941e-04 3.120 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.376210e-04 3.132 1 0
Gap junction trafficking R-HSA-190828 7.672000e-04 3.115 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.970816e-04 3.098 0 0
Semaphorin interactions R-HSA-373755 8.200972e-04 3.086 0 0
DNA Double Strand Break Response R-HSA-5693606 8.440876e-04 3.074 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.969146e-04 3.047 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.122451e-04 3.040 0 0
Oncogene Induced Senescence R-HSA-2559585 9.194923e-04 3.036 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.603551e-04 3.018 0 0
RAB geranylgeranylation R-HSA-8873719 9.665625e-04 3.015 0 0
DAG and IP3 signaling R-HSA-1489509 9.680659e-04 3.014 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.964129e-04 3.002 1 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.035431e-03 2.985 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.050291e-03 2.979 0 0
Death Receptor Signaling R-HSA-73887 1.092092e-03 2.962 1 0
Programmed Cell Death R-HSA-5357801 1.104143e-03 2.957 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.212581e-03 2.916 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.212581e-03 2.916 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.212581e-03 2.916 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.212581e-03 2.916 0 0
Signaling by RAS mutants R-HSA-6802949 1.212581e-03 2.916 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.284126e-03 2.891 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.312484e-03 2.882 0 0
Translation initiation complex formation R-HSA-72649 1.342317e-03 2.872 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.449586e-03 2.839 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.377774e-03 2.861 0 0
Ub-specific processing proteases R-HSA-5689880 1.446623e-03 2.840 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.468873e-03 2.833 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.715891e-03 2.766 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.715891e-03 2.766 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.765310e-03 2.753 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.765310e-03 2.753 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.765310e-03 2.753 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.770698e-03 2.752 0 0
Cell-cell junction organization R-HSA-421270 1.818527e-03 2.740 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.936311e-03 2.713 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.959468e-03 2.708 1 1
Ion homeostasis R-HSA-5578775 1.991989e-03 2.701 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.934887e-03 2.713 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.994224e-03 2.700 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.023859e-03 2.694 0 0
PKR-mediated signaling R-HSA-9833482 2.047400e-03 2.689 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.090705e-03 2.680 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.126546e-03 2.672 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.126546e-03 2.672 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.254189e-03 2.647 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 2.664680e-03 2.574 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.664680e-03 2.574 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.620497e-03 2.582 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.620497e-03 2.582 0 0
Protein folding R-HSA-391251 2.630225e-03 2.580 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.563817e-03 2.591 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.578822e-03 2.589 0 0
Adherens junctions interactions R-HSA-418990 2.521143e-03 2.598 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.845581e-03 2.546 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.850605e-03 2.545 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.851361e-03 2.545 0 0
Calmodulin induced events R-HSA-111933 2.851361e-03 2.545 0 0
CaM pathway R-HSA-111997 2.851361e-03 2.545 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.891861e-03 2.539 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.912535e-03 2.536 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.946701e-03 2.531 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.949553e-03 2.530 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.039483e-03 2.517 0 0
Defective pyroptosis R-HSA-9710421 3.187806e-03 2.497 0 0
MAPK family signaling cascades R-HSA-5683057 3.220929e-03 2.492 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.234834e-03 2.490 1 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.430938e-03 2.465 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.574379e-03 2.447 0 0
Cleavage of the damaged purine R-HSA-110331 3.574379e-03 2.447 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.763548e-03 2.424 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.763548e-03 2.424 0 0
Interleukin-1 family signaling R-HSA-446652 3.823682e-03 2.418 1 0
Chaperone Mediated Autophagy R-HSA-9613829 3.837648e-03 2.416 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.866179e-03 2.413 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.871442e-03 2.412 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.871442e-03 2.412 1 1
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.871442e-03 2.412 1 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.949628e-03 2.403 0 0
RAF activation R-HSA-5673000 4.199946e-03 2.377 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.106051e-03 2.387 0 0
Peptide chain elongation R-HSA-156902 4.251004e-03 2.372 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.127319e-03 2.384 0 0
FOXO-mediated transcription R-HSA-9614085 4.417401e-03 2.355 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.035088e-03 2.394 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.035088e-03 2.394 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.417401e-03 2.355 1 0
NOD1/2 Signaling Pathway R-HSA-168638 4.199946e-03 2.377 1 1
Gap junction assembly R-HSA-190861 4.199946e-03 2.377 0 0
Depurination R-HSA-73927 4.442390e-03 2.352 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.610655e-03 2.336 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.624649e-03 2.335 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.624649e-03 2.335 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.680518e-03 2.330 0 0
Signaling by ROBO receptors R-HSA-376176 4.711163e-03 2.327 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.824683e-03 2.317 0 0
MHC class II antigen presentation R-HSA-2132295 4.985595e-03 2.302 0 0
Glycolysis R-HSA-70171 5.027070e-03 2.299 0 0
The NLRP3 inflammasome R-HSA-844456 5.223366e-03 2.282 0 0
Co-inhibition by PD-1 R-HSA-389948 5.430207e-03 2.265 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.430207e-03 2.265 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.437884e-03 2.265 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.592284e-03 2.252 0 0
Ca-dependent events R-HSA-111996 5.641344e-03 2.249 0 0
Signaling by WNT R-HSA-195721 5.729599e-03 2.242 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.736497e-03 2.241 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.747165e-03 2.241 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.606415e-03 2.180 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.182708e-03 2.209 0 0
Centrosome maturation R-HSA-380287 6.309733e-03 2.200 0 0
Neutrophil degranulation R-HSA-6798695 6.031754e-03 2.220 0 0
RET signaling R-HSA-8853659 6.484964e-03 2.188 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.466058e-03 2.189 0 0
Rab regulation of trafficking R-HSA-9007101 6.854934e-03 2.164 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.965669e-03 2.157 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.965669e-03 2.157 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.965669e-03 2.157 0 0
HATs acetylate histones R-HSA-3214847 7.612112e-03 2.118 0 0
Ion transport by P-type ATPases R-HSA-936837 7.857103e-03 2.105 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.130412e-03 2.090 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.130412e-03 2.090 0 0
Reproduction R-HSA-1474165 8.201026e-03 2.086 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.220102e-03 2.085 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.220102e-03 2.085 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.422336e-03 2.075 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.422336e-03 2.075 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.552995e-03 2.068 1 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.552995e-03 2.068 1 1
Hedgehog 'off' state R-HSA-5610787 8.589727e-03 2.066 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 9.681629e-03 2.014 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 9.871042e-03 2.006 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.941262e-03 2.049 0 0
Trafficking of AMPA receptors R-HSA-399719 9.094764e-03 2.041 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.756939e-03 2.011 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.007989e-03 2.045 0 0
PLC beta mediated events R-HSA-112043 9.350088e-03 2.029 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.941262e-03 2.049 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.935924e-03 2.049 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.018615e-03 2.045 0 0
G alpha (12/13) signalling events R-HSA-416482 9.611449e-03 2.017 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.646922e-03 2.063 0 0
Vesicle-mediated transport R-HSA-5653656 1.052811e-02 1.978 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.054550e-02 1.977 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.056587e-02 1.976 0 0
Cellular response to heat stress R-HSA-3371556 1.058635e-02 1.975 0 0
Chromosome Maintenance R-HSA-73886 1.058635e-02 1.975 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.070268e-02 1.971 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.070268e-02 1.971 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.077217e-02 1.968 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.103990e-02 1.957 0 0
Glucose metabolism R-HSA-70326 1.113373e-02 1.953 0 0
Protein ubiquitination R-HSA-8852135 1.139448e-02 1.943 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.158872e-02 1.936 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.172962e-02 1.931 0 0
Depyrimidination R-HSA-73928 1.172962e-02 1.931 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.174323e-02 1.930 1 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.174323e-02 1.930 1 0
Transmission across Chemical Synapses R-HSA-112315 1.176065e-02 1.930 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.201133e-02 1.920 0 0
G-protein mediated events R-HSA-112040 1.219932e-02 1.914 0 0
Gene Silencing by RNA R-HSA-211000 1.293480e-02 1.888 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.301120e-02 1.886 0 0
Platelet calcium homeostasis R-HSA-418360 1.336584e-02 1.874 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.351416e-02 1.869 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.375634e-02 1.861 0 0
Rap1 signalling R-HSA-392517 1.384193e-02 1.859 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.632086e-02 1.787 0 0
Signaling by MAPK mutants R-HSA-9652817 1.632086e-02 1.787 0 0
Co-stimulation by CD28 R-HSA-389356 1.619187e-02 1.791 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.401335e-02 1.853 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.510878e-02 1.821 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.600748e-02 1.796 1 1
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.440510e-02 1.841 1 1
Cellular response to chemical stress R-HSA-9711123 1.422189e-02 1.847 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.502025e-02 1.823 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.619187e-02 1.791 0 0
Neuronal System R-HSA-112316 1.445273e-02 1.840 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.633489e-02 1.787 0 0
NRAGE signals death through JNK R-HSA-193648 1.542303e-02 1.812 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.664909e-02 1.779 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.668090e-02 1.778 0 0
RNA Polymerase I Transcription R-HSA-73864 1.679452e-02 1.775 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.685633e-02 1.773 1 0
MAP kinase activation R-HSA-450294 1.725310e-02 1.763 1 0
MyD88-independent TLR4 cascade R-HSA-166166 1.774995e-02 1.751 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.774995e-02 1.751 1 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.793287e-02 1.746 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.793287e-02 1.746 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.793287e-02 1.746 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.850112e-02 1.733 0 0
Regulation of KIT signaling R-HSA-1433559 1.861394e-02 1.730 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.961920e-02 1.707 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.966045e-02 1.706 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.997546e-02 1.700 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.007585e-02 1.697 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.076700e-02 1.683 0 0
Influenza Infection R-HSA-168255 2.097306e-02 1.678 0 0
Activation of RAC1 R-HSA-428540 2.124460e-02 1.673 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.124460e-02 1.673 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.124460e-02 1.673 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.168430e-02 1.664 0 0
Opioid Signalling R-HSA-111885 2.186070e-02 1.660 0 0
Eukaryotic Translation Termination R-HSA-72764 2.189594e-02 1.660 0 0
Interleukin-12 signaling R-HSA-9020591 2.243687e-02 1.649 0 0
Signaling by NTRKs R-HSA-166520 2.256559e-02 1.647 0 0
Diseases of DNA repair R-HSA-9675135 2.260407e-02 1.646 0 0
ALK mutants bind TKIs R-HSA-9700645 2.373613e-02 1.625 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.389951e-02 1.622 1 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.870681e-02 1.542 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.870681e-02 1.542 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.870681e-02 1.542 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.870681e-02 1.542 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.870681e-02 1.542 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.461178e-02 1.609 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.809621e-02 1.551 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.809621e-02 1.551 0 0
Chromatin modifying enzymes R-HSA-3247509 2.656542e-02 1.576 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.395651e-02 1.621 0 0
Signaling by SCF-KIT R-HSA-1433557 2.705713e-02 1.568 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.809577e-02 1.551 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.870681e-02 1.542 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.565753e-02 1.591 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.628428e-02 1.580 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.829594e-02 1.548 0 0
Signalling to ERKs R-HSA-187687 2.395651e-02 1.621 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.809621e-02 1.551 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.461178e-02 1.609 0 0
Polo-like kinase mediated events R-HSA-156711 2.679341e-02 1.572 0 0
Selenocysteine synthesis R-HSA-2408557 2.553315e-02 1.593 0 0
Long-term potentiation R-HSA-9620244 2.875396e-02 1.541 0 0
Integrin signaling R-HSA-354192 2.878002e-02 1.541 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.878002e-02 1.541 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.893950e-02 1.539 0 0
Ribosome-associated quality control R-HSA-9948299 2.907390e-02 1.536 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.918053e-02 1.535 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.985758e-02 1.525 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.070808e-02 1.513 1 1
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.134865e-02 1.504 0 0
Netrin-1 signaling R-HSA-373752 3.140731e-02 1.503 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.160588e-02 1.500 1 0
Interleukin-12 family signaling R-HSA-447115 3.173459e-02 1.498 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.230628e-02 1.491 0 0
Cardiac conduction R-HSA-5576891 3.260167e-02 1.487 0 0
Cilium Assembly R-HSA-5617833 3.308873e-02 1.480 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.310149e-02 1.480 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.310149e-02 1.480 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.310149e-02 1.480 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.335173e-02 1.477 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.367730e-02 1.473 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.367730e-02 1.473 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.411193e-02 1.467 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.411193e-02 1.467 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.727551e-02 1.429 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.727551e-02 1.429 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.727551e-02 1.429 0 0
Diseases of cellular response to stress R-HSA-9675132 3.727551e-02 1.429 0 0
DSCAM interactions R-HSA-376172 3.727551e-02 1.429 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.727551e-02 1.429 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.727551e-02 1.429 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.727551e-02 1.429 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.006007e-02 1.397 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.006007e-02 1.397 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.776472e-02 1.423 0 0
Formation of axial mesoderm R-HSA-9796292 3.776472e-02 1.423 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.776472e-02 1.423 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.776472e-02 1.423 0 0
Disorders of Developmental Biology R-HSA-9675151 4.040787e-02 1.394 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.169294e-02 1.380 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.169294e-02 1.380 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.169294e-02 1.380 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.169294e-02 1.380 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.169294e-02 1.380 0 0
Nuclear import of Rev protein R-HSA-180746 4.011751e-02 1.397 0 0
HDACs deacetylate histones R-HSA-3214815 4.313952e-02 1.365 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.211887e-02 1.376 0 0
Chromatin organization R-HSA-4839726 3.686698e-02 1.433 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.878457e-02 1.411 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.732816e-02 1.428 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.205773e-02 1.376 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.536611e-02 1.451 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.901441e-02 1.409 0 0
Signaling by PTK6 R-HSA-8848021 3.901441e-02 1.409 0 0
Adaptive Immune System R-HSA-1280218 3.879984e-02 1.411 0 0
DNA Repair R-HSA-73894 4.079873e-02 1.389 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.814783e-02 1.419 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.458794e-02 1.461 0 0
Developmental Biology R-HSA-1266738 4.294698e-02 1.367 0 0
Signaling by NOTCH R-HSA-157118 3.868364e-02 1.412 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.915518e-02 1.407 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.040787e-02 1.394 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.803955e-02 1.420 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.340694e-02 1.362 0 0
Ca2+ pathway R-HSA-4086398 4.394137e-02 1.357 0 0
Signaling by APC mutants R-HSA-4839744 4.457916e-02 1.351 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.457916e-02 1.351 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.457916e-02 1.351 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.457916e-02 1.351 0 0
PECAM1 interactions R-HSA-210990 4.457916e-02 1.351 0 0
Signaling by ALK R-HSA-201556 4.516099e-02 1.345 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.516099e-02 1.345 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.616211e-02 1.336 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.622202e-02 1.335 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.752523e-02 1.323 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.835748e-02 1.316 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.851999e-02 1.314 0 0
HCMV Early Events R-HSA-9609690 4.921535e-02 1.308 0 0
Inflammasomes R-HSA-622312 4.964387e-02 1.304 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.037867e-02 1.298 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.037867e-02 1.298 0 0
ERK/MAPK targets R-HSA-198753 5.090282e-02 1.293 0 0
Neurexins and neuroligins R-HSA-6794361 5.130940e-02 1.290 0 0
Interleukin-17 signaling R-HSA-448424 5.172156e-02 1.286 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 5.182123e-02 1.285 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 5.182123e-02 1.285 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 5.182123e-02 1.285 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 5.182123e-02 1.285 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.204928e-02 1.284 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.211097e-02 1.283 0 0
RSK activation R-HSA-444257 5.211097e-02 1.283 0 0
Formation of annular gap junctions R-HSA-196025 5.211097e-02 1.283 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.242347e-02 1.280 0 0
Immune System R-HSA-168256 5.408159e-02 1.267 1 0
ISG15 antiviral mechanism R-HSA-1169408 5.416547e-02 1.266 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.459931e-02 1.263 0 0
Regulation of CDH1 Function R-HSA-9764561 5.478028e-02 1.261 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.522450e-02 1.258 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.644399e-02 1.248 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.644399e-02 1.248 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 6.393040e-02 1.194 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.955757e-02 1.225 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.955757e-02 1.225 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.955757e-02 1.225 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.955757e-02 1.225 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.955757e-02 1.225 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.955757e-02 1.225 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.955757e-02 1.225 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.955757e-02 1.225 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.985327e-02 1.156 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.985327e-02 1.156 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.985327e-02 1.156 0 0
Gap junction degradation R-HSA-190873 6.985327e-02 1.156 0 0
CASP8 activity is inhibited R-HSA-5218900 6.985327e-02 1.156 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.420006e-02 1.130 0 0
Pervasive developmental disorders R-HSA-9005895 7.420006e-02 1.130 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.420006e-02 1.130 0 0
Disorders of Nervous System Development R-HSA-9697154 7.420006e-02 1.130 0 0
p38MAPK events R-HSA-171007 6.104296e-02 1.214 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.104296e-02 1.214 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.104296e-02 1.214 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.537076e-02 1.123 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.819105e-02 1.166 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.819105e-02 1.166 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.538986e-02 1.184 0 0
MAP2K and MAPK activation R-HSA-5674135 6.791977e-02 1.168 0 0
Viral mRNA Translation R-HSA-192823 7.091375e-02 1.149 0 0
Interleukin-1 signaling R-HSA-9020702 6.011187e-02 1.221 1 1
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.181395e-02 1.209 0 0
Telomere Maintenance R-HSA-157579 6.384668e-02 1.195 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.850873e-02 1.233 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.420006e-02 1.130 1 1
Platelet Aggregation (Plug Formation) R-HSA-76009 6.442758e-02 1.191 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.081067e-02 1.150 0 0
Host Interactions of HIV factors R-HSA-162909 7.127905e-02 1.147 0 0
p75NTR signals via NF-kB R-HSA-193639 6.104296e-02 1.214 1 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.384668e-02 1.195 0 0
ESR-mediated signaling R-HSA-8939211 7.524775e-02 1.124 0 0
Signaling by TGFB family members R-HSA-9006936 7.667323e-02 1.115 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 6.393040e-02 1.194 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.420006e-02 1.130 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.420006e-02 1.130 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.843271e-02 1.233 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.843271e-02 1.233 0 0
Activation of BH3-only proteins R-HSA-114452 6.819105e-02 1.166 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.621550e-02 1.179 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.796029e-02 1.237 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.537076e-02 1.123 0 0
PI Metabolism R-HSA-1483255 6.535605e-02 1.185 0 0
Signaling by AXIN mutants R-HSA-4839735 5.826493e-02 1.235 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.181395e-02 1.209 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.135546e-02 1.212 0 0
Base Excision Repair R-HSA-73884 6.609179e-02 1.180 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.997933e-02 1.222 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.053229e-02 1.218 1 0
MITF-M-dependent gene expression R-HSA-9856651 7.568629e-02 1.121 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.112485e-02 1.214 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.955757e-02 1.225 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.808758e-02 1.107 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.894011e-02 1.103 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.894011e-02 1.103 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.018477e-02 1.096 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.085496e-02 1.092 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.085496e-02 1.092 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.134592e-02 1.090 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.134592e-02 1.090 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.134592e-02 1.090 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.172046e-02 1.088 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.261427e-02 1.083 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.323040e-02 1.080 0 0
CREB phosphorylation R-HSA-199920 8.323040e-02 1.080 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.593941e-02 1.066 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.593941e-02 1.066 0 0
TBC/RABGAPs R-HSA-8854214 8.670155e-02 1.062 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.683790e-02 1.061 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.919515e-02 1.050 0 0
Formation of definitive endoderm R-HSA-9823730 8.919515e-02 1.050 0 0
Signal transduction by L1 R-HSA-445144 8.919515e-02 1.050 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.968813e-02 1.047 0 0
Pexophagy R-HSA-9664873 9.051246e-02 1.043 0 0
Regulation of CDH11 function R-HSA-9762292 9.051246e-02 1.043 0 0
Tandem pore domain potassium channels R-HSA-1296346 9.051246e-02 1.043 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 9.051246e-02 1.043 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.057312e-02 1.043 0 0
G0 and Early G1 R-HSA-1538133 9.069185e-02 1.042 0 0
Intraflagellar transport R-HSA-5620924 9.139029e-02 1.039 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.150679e-02 1.039 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.198118e-02 1.036 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.198118e-02 1.036 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.520157e-02 1.021 0 0
Smooth Muscle Contraction R-HSA-445355 9.550283e-02 1.020 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 9.714431e-02 1.013 0 0
Dopamine receptors R-HSA-390651 9.714431e-02 1.013 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 9.714431e-02 1.013 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 9.714431e-02 1.013 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 9.714431e-02 1.013 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 9.714431e-02 1.013 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 9.714431e-02 1.013 0 0
RUNX2 regulates bone development R-HSA-8941326 9.756467e-02 1.011 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.756467e-02 1.011 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.855443e-02 1.006 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.017280e-01 0.993 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.034487e-01 0.985 0 0
G-protein beta:gamma signalling R-HSA-397795 1.034487e-01 0.985 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.035124e-01 0.985 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.038145e-01 0.984 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.038145e-01 0.984 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.038145e-01 0.984 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.038145e-01 0.984 0 0
IKBKB deficiency causes SCID R-HSA-5602636 1.038145e-01 0.984 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.038145e-01 0.984 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.038145e-01 0.984 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 1.038145e-01 0.984 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.038145e-01 0.984 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.038145e-01 0.984 0 0
Signalling to RAS R-HSA-167044 1.051429e-01 0.978 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.056992e-01 0.976 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.075565e-01 0.968 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.094215e-01 0.961 0 0
Late endosomal microautophagy R-HSA-9615710 1.096145e-01 0.960 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.100920e-01 0.958 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.107993e-01 0.955 0 0
Netrin mediated repulsion signals R-HSA-418886 1.107993e-01 0.955 0 0
Regulation of PTEN localization R-HSA-8948747 1.107993e-01 0.955 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.658469e-01 0.780 0 0
KIT mutants bind TKIs R-HSA-9669921 1.658469e-01 0.780 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.658469e-01 0.780 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.658469e-01 0.780 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.658469e-01 0.780 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.658469e-01 0.780 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.658469e-01 0.780 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.658469e-01 0.780 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.658469e-01 0.780 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.658469e-01 0.780 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.658469e-01 0.780 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.658469e-01 0.780 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.658469e-01 0.780 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.658469e-01 0.780 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.658469e-01 0.780 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.658469e-01 0.780 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.646443e-01 0.783 0 0
Regulation of TP53 Expression R-HSA-6804754 1.646443e-01 0.783 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.646443e-01 0.783 0 0
C6 deamination of adenosine R-HSA-75102 1.646443e-01 0.783 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.358476e-01 0.867 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.358476e-01 0.867 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 1.358476e-01 0.867 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.358476e-01 0.867 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.358476e-01 0.867 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.358476e-01 0.867 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.418523e-01 0.848 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.418523e-01 0.848 0 0
Regulation by c-FLIP R-HSA-3371378 1.418523e-01 0.848 0 0
Dimerization of procaspase-8 R-HSA-69416 1.418523e-01 0.848 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.399916e-01 0.854 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.683488e-01 0.774 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.683488e-01 0.774 1 1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.683488e-01 0.774 1 1
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.290544e-01 0.889 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 1.594513e-01 0.797 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.594513e-01 0.797 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.594513e-01 0.797 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.160164e-01 0.935 0 0
Signaling by KIT in disease R-HSA-9669938 1.413905e-01 0.850 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.413905e-01 0.850 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.413905e-01 0.850 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.328579e-01 0.877 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.172033e-01 0.931 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.172033e-01 0.931 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.509001e-01 0.821 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.509001e-01 0.821 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.700824e-01 0.769 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.197612e-01 0.922 0 0
snRNP Assembly R-HSA-191859 1.661451e-01 0.780 0 0
Metabolism of non-coding RNA R-HSA-194441 1.661451e-01 0.780 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.498101e-01 0.824 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.428524e-01 0.845 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.589004e-01 0.799 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.469077e-01 0.833 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.160799e-01 0.935 0 0
Ephrin signaling R-HSA-3928664 1.290544e-01 0.889 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.328579e-01 0.877 0 0
Prolonged ERK activation events R-HSA-169893 1.594513e-01 0.797 0 0
G1 Phase R-HSA-69236 1.573115e-01 0.803 0 0
Cyclin D associated events in G1 R-HSA-69231 1.573115e-01 0.803 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.509001e-01 0.821 0 0
MTOR signalling R-HSA-165159 1.287895e-01 0.890 0 0
S Phase R-HSA-69242 1.223098e-01 0.913 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.249613e-01 0.903 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.551429e-01 0.809 0 0
Adrenoceptors R-HSA-390696 1.418523e-01 0.848 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.160164e-01 0.935 0 0
Metalloprotease DUBs R-HSA-5689901 1.328579e-01 0.877 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.358476e-01 0.867 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.418523e-01 0.848 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.503165e-01 0.823 0 0
TNF signaling R-HSA-75893 1.280084e-01 0.893 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.638008e-01 0.786 0 0
Interleukin-9 signaling R-HSA-8985947 1.418523e-01 0.848 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.594513e-01 0.797 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.594513e-01 0.797 0 0
TGFBR3 expression R-HSA-9839394 1.160164e-01 0.935 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.413905e-01 0.850 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.615641e-01 0.792 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.615641e-01 0.792 0 0
Signaling by WNT in cancer R-HSA-4791275 1.583453e-01 0.800 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.287895e-01 0.890 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.689403e-01 0.772 0 0
Toll-like Receptor Cascades R-HSA-168898 1.150396e-01 0.939 1 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.181812e-01 0.927 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.181812e-01 0.927 0 0
Signaling by Hedgehog R-HSA-5358351 1.150426e-01 0.939 0 0
Repression of WNT target genes R-HSA-4641265 1.683488e-01 0.774 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.509001e-01 0.821 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.235129e-01 0.908 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.303893e-01 0.885 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.160164e-01 0.935 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.399916e-01 0.854 0 0
Cellular response to starvation R-HSA-9711097 1.223091e-01 0.913 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.451657e-01 0.838 0 0
Signaling by TGFBR3 R-HSA-9839373 1.204773e-01 0.919 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.646443e-01 0.783 0 0
NrCAM interactions R-HSA-447038 1.358476e-01 0.867 0 0
Syndecan interactions R-HSA-3000170 1.615641e-01 0.792 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.570617e-01 0.804 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.225592e-01 0.912 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 1.358476e-01 0.867 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.172033e-01 0.931 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.290544e-01 0.889 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.155877e-01 0.937 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.573115e-01 0.803 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.727044e-01 0.763 0 0
Nephrin family interactions R-HSA-373753 1.730939e-01 0.762 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.730939e-01 0.762 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.735859e-01 0.760 0 0
TCR signaling R-HSA-202403 1.736018e-01 0.760 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.736928e-01 0.760 0 0
mRNA Splicing R-HSA-72172 1.752762e-01 0.756 0 0
Interleukin-1 processing R-HSA-448706 1.758876e-01 0.755 0 0
Lipophagy R-HSA-9613354 1.758876e-01 0.755 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.758876e-01 0.755 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.758876e-01 0.755 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.758876e-01 0.755 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.758876e-01 0.755 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.758876e-01 0.755 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.758876e-01 0.755 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.758876e-01 0.755 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.766350e-01 0.753 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.766350e-01 0.753 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.788402e-01 0.748 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.788402e-01 0.748 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.788402e-01 0.748 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.788402e-01 0.748 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.788402e-01 0.748 0 0
Signaling by ERBB2 R-HSA-1227986 1.800458e-01 0.745 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.817262e-01 0.741 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 1.829900e-01 0.738 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.830535e-01 0.737 0 0
Platelet homeostasis R-HSA-418346 1.843956e-01 0.734 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.855096e-01 0.732 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 1.888106e-01 0.724 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 1.888106e-01 0.724 0 0
HSF1-dependent transactivation R-HSA-3371571 1.912295e-01 0.718 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.930940e-01 0.714 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.958551e-01 0.708 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.962757e-01 0.707 0 0
Amyloid fiber formation R-HSA-977225 1.969956e-01 0.706 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.972516e-01 0.705 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.972516e-01 0.705 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 1.972516e-01 0.705 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.985269e-01 0.702 1 1
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.987279e-01 0.702 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.987279e-01 0.702 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.987279e-01 0.702 0 0
Interleukin-6 signaling R-HSA-1059683 1.987279e-01 0.702 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.987279e-01 0.702 0 0
Maturation of nucleoprotein R-HSA-9683610 1.987279e-01 0.702 0 0
G1/S Transition R-HSA-69206 2.028973e-01 0.693 0 0
Interleukin-7 signaling R-HSA-1266695 2.055633e-01 0.687 0 0
Tight junction interactions R-HSA-420029 2.055633e-01 0.687 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.055922e-01 0.687 1 1
SARS-CoV-2 Infection R-HSA-9694516 2.056437e-01 0.687 1 0
DNA Replication R-HSA-69306 2.056526e-01 0.687 0 0
Heme signaling R-HSA-9707616 2.095010e-01 0.679 0 0
SARS-CoV Infections R-HSA-9679506 2.095457e-01 0.679 1 0
Activation, translocation and oligomerization of BAX R-HSA-114294 3.041964e-01 0.517 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.041964e-01 0.517 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.041964e-01 0.517 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.041964e-01 0.517 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.041964e-01 0.517 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 3.041964e-01 0.517 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 3.041964e-01 0.517 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 3.041964e-01 0.517 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 3.041964e-01 0.517 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 3.041964e-01 0.517 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 3.041964e-01 0.517 0 0
Tandem pore domain halothane-inhibited K+ channel (THIK) R-HSA-1299287 3.041964e-01 0.517 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.041964e-01 0.517 0 0
Defective SLC33A1 causes spastic paraplegia 42 (SPG42) R-HSA-5619061 3.041964e-01 0.517 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.041964e-01 0.517 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 3.041964e-01 0.517 0 0
Blockage of phagosome acidification R-HSA-9636467 3.041964e-01 0.517 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 3.041964e-01 0.517 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 3.041964e-01 0.517 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 3.041964e-01 0.517 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.299514e-01 0.638 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.299514e-01 0.638 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.299514e-01 0.638 0 0
Classical Kir channels R-HSA-1296053 2.299514e-01 0.638 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.299514e-01 0.638 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.249149e-01 0.648 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 2.249149e-01 0.648 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.249149e-01 0.648 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 2.249149e-01 0.648 0 0
Regulation of gap junction activity R-HSA-191650 2.965791e-01 0.528 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.965791e-01 0.528 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.965791e-01 0.528 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.965791e-01 0.528 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.965791e-01 0.528 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.965791e-01 0.528 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.123525e-01 0.673 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.729346e-01 0.564 0 0
PTK6 Expression R-HSA-8849473 2.729346e-01 0.564 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.729346e-01 0.564 0 0
Disinhibition of SNARE formation R-HSA-114516 2.729346e-01 0.564 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.729346e-01 0.564 0 0
SOS-mediated signalling R-HSA-112412 2.729346e-01 0.564 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.729346e-01 0.564 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 3.622937e-01 0.441 0 0
Co-inhibition by BTLA R-HSA-9927353 3.622937e-01 0.441 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.622937e-01 0.441 0 0
IRS activation R-HSA-74713 3.622937e-01 0.441 0 0
G2 Phase R-HSA-68911 3.622937e-01 0.441 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 3.622937e-01 0.441 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.622937e-01 0.441 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.622937e-01 0.441 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.307974e-01 0.637 0 0
Retrograde neurotrophin signalling R-HSA-177504 2.307974e-01 0.637 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.130947e-01 0.671 0 0
Type I hemidesmosome assembly R-HSA-446107 3.218775e-01 0.492 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.218775e-01 0.492 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.218775e-01 0.492 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.902909e-01 0.537 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.902909e-01 0.537 0 0
DCC mediated attractive signaling R-HSA-418885 2.642115e-01 0.578 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.642115e-01 0.578 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.419813e-01 0.616 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.419813e-01 0.616 0 0
PKA activation in glucagon signalling R-HSA-164378 2.419813e-01 0.616 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.291669e-01 0.640 0 0
Notch-HLH transcription pathway R-HSA-350054 2.490876e-01 0.604 0 0
Translesion Synthesis by POLH R-HSA-110320 2.719331e-01 0.566 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.986211e-01 0.525 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.986211e-01 0.525 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.306614e-01 0.481 0 0
Leading Strand Synthesis R-HSA-69109 3.306614e-01 0.481 0 0
Regulation of IFNG signaling R-HSA-877312 3.306614e-01 0.481 0 0
Polymerase switching R-HSA-69091 3.306614e-01 0.481 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.306614e-01 0.481 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.306614e-01 0.481 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.708595e-01 0.431 0 0
ARMS-mediated activation R-HSA-170984 3.708595e-01 0.431 0 0
Interleukin-21 signaling R-HSA-9020958 3.708595e-01 0.431 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.159365e-01 0.666 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.536741e-01 0.596 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.191184e-01 0.659 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.336845e-01 0.477 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.336845e-01 0.477 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.336845e-01 0.477 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.565981e-01 0.591 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.789512e-01 0.554 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.712892e-01 0.430 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.712892e-01 0.430 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 3.712892e-01 0.430 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.583718e-01 0.588 0 0
HSF1 activation R-HSA-3371511 2.583718e-01 0.588 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.801913e-01 0.553 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.340690e-01 0.476 1 1
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.340690e-01 0.476 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.191410e-01 0.378 0 0
2-LTR circle formation R-HSA-164843 4.191410e-01 0.378 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.191410e-01 0.378 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.596625e-01 0.586 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.596625e-01 0.586 0 0
HDMs demethylate histones R-HSA-3214842 3.330626e-01 0.477 0 0
G alpha (z) signalling events R-HSA-418597 2.590803e-01 0.587 0 0
Activation of the pre-replicative complex R-HSA-68962 3.312601e-01 0.480 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.312601e-01 0.480 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.657789e-01 0.437 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.657789e-01 0.437 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.117265e-01 0.385 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.117265e-01 0.385 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.289788e-01 0.483 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.620009e-01 0.441 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.044868e-01 0.393 0 0
GPER1 signaling R-HSA-9634597 3.207697e-01 0.494 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.458444e-01 0.609 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.911211e-01 0.408 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.866918e-01 0.543 0 0
RMTs methylate histone arginines R-HSA-3214858 3.458431e-01 0.461 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.849768e-01 0.415 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.267011e-01 0.486 0 0
PTEN Regulation R-HSA-6807070 2.655135e-01 0.576 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.974601e-01 0.401 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.974601e-01 0.401 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.974601e-01 0.401 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.593210e-01 0.586 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.541677e-01 0.451 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.161405e-01 0.500 0 0
Interleukin-15 signaling R-HSA-8983432 3.306614e-01 0.481 0 0
DNA Damage Bypass R-HSA-73893 3.418666e-01 0.466 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.115645e-01 0.675 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.565981e-01 0.591 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.419813e-01 0.616 0 0
Downstream TCR signaling R-HSA-202424 3.445411e-01 0.463 0 0
Mitophagy R-HSA-5205647 3.289788e-01 0.483 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.506752e-01 0.601 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.620009e-01 0.441 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.948867e-01 0.404 1 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.620009e-01 0.441 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.902909e-01 0.537 0 0
mRNA Editing R-HSA-75072 3.708595e-01 0.431 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 2.803017e-01 0.552 0 0
Interleukin-2 family signaling R-HSA-451927 2.389022e-01 0.622 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.306614e-01 0.481 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 3.712892e-01 0.430 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.911211e-01 0.408 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.562692e-01 0.591 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.307974e-01 0.637 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.044790e-01 0.516 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.178326e-01 0.498 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.735941e-01 0.428 0 0
Potassium Channels R-HSA-1296071 2.343091e-01 0.630 0 0
Frs2-mediated activation R-HSA-170968 3.712892e-01 0.430 0 0
GPVI-mediated activation cascade R-HSA-114604 3.791458e-01 0.421 0 0
Formation of the posterior neural plate R-HSA-9832991 2.506752e-01 0.601 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.191410e-01 0.378 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.330626e-01 0.477 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.043559e-01 0.517 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.117265e-01 0.385 0 0
Integration of energy metabolism R-HSA-163685 2.917509e-01 0.535 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.795999e-01 0.553 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.976146e-01 0.401 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.986211e-01 0.525 0 0
Regulation of insulin secretion R-HSA-422356 2.609829e-01 0.583 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 3.405084e-01 0.468 0 0
Leukotriene receptors R-HSA-391906 2.249149e-01 0.648 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.506752e-01 0.601 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.642115e-01 0.578 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.226378e-01 0.652 1 1
Processing of SMDT1 R-HSA-8949664 3.712892e-01 0.430 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.890580e-01 0.539 0 0
Interleukin-2 signaling R-HSA-9020558 2.506752e-01 0.601 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.289788e-01 0.483 0 0
Myogenesis R-HSA-525793 3.620009e-01 0.441 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.394144e-01 0.621 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.117265e-01 0.385 0 0
NF-kB is activated and signals survival R-HSA-209560 2.902909e-01 0.537 1 1
PKA activation R-HSA-163615 2.419813e-01 0.616 0 0
mTORC1-mediated signalling R-HSA-166208 2.490876e-01 0.604 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.719331e-01 0.566 0 0
Signaling by NODAL R-HSA-1181150 3.027090e-01 0.519 0 0
DARPP-32 events R-HSA-180024 3.048600e-01 0.516 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.330626e-01 0.477 0 0
cGMP effects R-HSA-418457 4.117265e-01 0.385 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.236419e-01 0.490 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.682917e-01 0.434 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.490876e-01 0.604 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.580116e-01 0.446 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.418666e-01 0.466 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.123525e-01 0.673 0 0
TRP channels R-HSA-3295583 2.291669e-01 0.640 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.801913e-01 0.553 0 0
Signal attenuation R-HSA-74749 4.191410e-01 0.378 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.043559e-01 0.517 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.803017e-01 0.552 0 0
Triglyceride catabolism R-HSA-163560 3.791458e-01 0.421 0 0
Leishmania infection R-HSA-9658195 2.469245e-01 0.607 0 0
Parasitic Infection Pathways R-HSA-9824443 2.469245e-01 0.607 0 0
Apoptotic factor-mediated response R-HSA-111471 4.044868e-01 0.393 0 0
Sensory perception of sour taste R-HSA-9729555 2.965791e-01 0.528 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.965791e-01 0.528 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.622937e-01 0.441 0 0
Hydroxycarboxylic acid-binding receptors R-HSA-3296197 3.622937e-01 0.441 0 0
HDL assembly R-HSA-8963896 2.307974e-01 0.637 0 0
Protein methylation R-HSA-8876725 2.642115e-01 0.578 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.191410e-01 0.378 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.117265e-01 0.385 0 0
Regulated Necrosis R-HSA-5218859 2.250155e-01 0.648 0 0
Diseases of Immune System R-HSA-5260271 2.389022e-01 0.622 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.389022e-01 0.622 0 0
Signaling by NOTCH1 R-HSA-1980143 3.581141e-01 0.446 0 0
HCMV Infection R-HSA-9609646 2.989712e-01 0.524 0 0
Nef and signal transduction R-HSA-164944 2.249149e-01 0.648 0 0
CHL1 interactions R-HSA-447041 2.729346e-01 0.564 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.801913e-01 0.553 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.657789e-01 0.437 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.117265e-01 0.385 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.195856e-01 0.495 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.366592e-01 0.626 0 0
Plasma lipoprotein assembly R-HSA-8963898 3.044790e-01 0.516 0 0
tRNA processing in the nucleus R-HSA-6784531 3.932031e-01 0.405 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.131433e-01 0.384 0 0
Downstream signal transduction R-HSA-186763 3.580116e-01 0.446 0 0
Aquaporin-mediated transport R-HSA-445717 3.733519e-01 0.428 0 0
Interleukin-27 signaling R-HSA-9020956 4.191410e-01 0.378 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.690749e-01 0.433 0 0
Interferon Signaling R-HSA-913531 3.887395e-01 0.410 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.059969e-01 0.514 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.405084e-01 0.468 0 0
Hemostasis R-HSA-109582 2.866901e-01 0.543 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.622937e-01 0.441 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.291669e-01 0.640 0 0
Pyroptosis R-HSA-5620971 2.789512e-01 0.554 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.191410e-01 0.378 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.596625e-01 0.586 0 0
Regulation of beta-cell development R-HSA-186712 3.341283e-01 0.476 0 0
Ion channel transport R-HSA-983712 2.134667e-01 0.671 0 0
FLT3 Signaling R-HSA-9607240 2.593210e-01 0.586 0 0
Platelet degranulation R-HSA-114608 2.244168e-01 0.649 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.690749e-01 0.433 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.017681e-01 0.520 0 0
Platelet sensitization by LDL R-HSA-432142 4.044868e-01 0.393 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.063794e-01 0.391 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.729346e-01 0.564 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.708595e-01 0.431 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.708595e-01 0.431 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.562692e-01 0.591 0 0
Sensory processing of sound R-HSA-9659379 2.388356e-01 0.622 0 0
Signaling by Leptin R-HSA-2586552 4.191410e-01 0.378 0 0
Viral Infection Pathways R-HSA-9824446 3.474994e-01 0.459 1 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.622937e-01 0.441 0 0
Formation of the anterior neural plate R-HSA-9823739 2.642115e-01 0.578 0 0
Specification of primordial germ cells R-HSA-9827857 2.130947e-01 0.671 0 0
Signal regulatory protein family interactions R-HSA-391160 4.117265e-01 0.385 0 0
Other interleukin signaling R-HSA-449836 2.719331e-01 0.566 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.789023e-01 0.421 0 0
Maturation of nucleoprotein R-HSA-9694631 2.719331e-01 0.566 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.419813e-01 0.616 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.340690e-01 0.476 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.642115e-01 0.578 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.795999e-01 0.553 0 0
Selenoamino acid metabolism R-HSA-2408522 3.864346e-01 0.413 0 0
FGFR4 mutant receptor activation R-HSA-1839128 4.196063e-01 0.377 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 4.196063e-01 0.377 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 4.196063e-01 0.377 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 4.196063e-01 0.377 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 4.196063e-01 0.377 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 4.196063e-01 0.377 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 4.196063e-01 0.377 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 4.196063e-01 0.377 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 4.196063e-01 0.377 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 4.196063e-01 0.377 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 4.196063e-01 0.377 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 4.196063e-01 0.377 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 4.196063e-01 0.377 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 4.196063e-01 0.377 0 0
Defective VWF binding to collagen type I R-HSA-9845622 4.196063e-01 0.377 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 4.196063e-01 0.377 0 0
Defective CD320 causes MMATC R-HSA-3359485 4.196063e-01 0.377 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 4.196063e-01 0.377 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 4.196063e-01 0.377 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 4.196063e-01 0.377 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 4.196063e-01 0.377 0 0
NTRK3 as a dependence receptor R-HSA-9603505 4.196063e-01 0.377 0 0
TRAIL signaling R-HSA-75158 4.255658e-01 0.371 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.255658e-01 0.371 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 4.255658e-01 0.371 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 4.255658e-01 0.371 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.255658e-01 0.371 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.255658e-01 0.371 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 4.255658e-01 0.371 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 4.255658e-01 0.371 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 4.255658e-01 0.371 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 4.255658e-01 0.371 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 4.255658e-01 0.371 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 4.255658e-01 0.371 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 4.255658e-01 0.371 0 0
Mitochondrial biogenesis R-HSA-1592230 4.260091e-01 0.371 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.293657e-01 0.367 0 0
Growth hormone receptor signaling R-HSA-982772 4.293657e-01 0.367 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.295459e-01 0.367 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.298017e-01 0.367 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.298017e-01 0.367 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.396410e-01 0.357 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.396410e-01 0.357 0 0
HIV Infection R-HSA-162906 4.478539e-01 0.349 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.492560e-01 0.348 0 0
Erythropoietin activates RAS R-HSA-9027284 4.515807e-01 0.345 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.515807e-01 0.345 0 0
Translesion synthesis by REV1 R-HSA-110312 4.515807e-01 0.345 0 0
G beta:gamma signalling through BTK R-HSA-8964315 4.515807e-01 0.345 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.515807e-01 0.345 0 0
Signaling by Activin R-HSA-1502540 4.515807e-01 0.345 0 0
Stabilization of p53 R-HSA-69541 4.550486e-01 0.342 0 0
UCH proteinases R-HSA-5689603 4.557176e-01 0.341 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.578489e-01 0.339 0 0
Degradation of CDH1 R-HSA-9766229 4.589889e-01 0.338 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.608374e-01 0.336 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.608374e-01 0.336 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.608374e-01 0.336 0 0
Interleukin-6 family signaling R-HSA-6783589 4.608374e-01 0.336 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.618703e-01 0.335 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.618703e-01 0.335 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.618703e-01 0.335 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.618703e-01 0.335 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.618703e-01 0.335 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.640810e-01 0.333 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.640810e-01 0.333 0 0
Dual Incision in GG-NER R-HSA-5696400 4.658486e-01 0.332 0 0
Signal amplification R-HSA-392518 4.658486e-01 0.332 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.661237e-01 0.331 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.661237e-01 0.331 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.661237e-01 0.331 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.661237e-01 0.331 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.661237e-01 0.331 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.661237e-01 0.331 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.661237e-01 0.331 0 0
IRE1alpha activates chaperones R-HSA-381070 4.672662e-01 0.330 0 0
Amine ligand-binding receptors R-HSA-375280 4.690568e-01 0.329 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.713080e-01 0.327 0 0
Signaling by NOTCH3 R-HSA-9012852 4.713080e-01 0.327 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.742866e-01 0.324 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.761485e-01 0.322 0 0
Innate Immune System R-HSA-168249 4.776535e-01 0.321 1 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.779702e-01 0.321 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.779702e-01 0.321 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.779702e-01 0.321 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.801103e-01 0.319 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.801103e-01 0.319 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.825022e-01 0.317 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.832306e-01 0.316 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.853982e-01 0.314 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.853982e-01 0.314 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 4.853982e-01 0.314 0 0
G2/M DNA replication checkpoint R-HSA-69478 4.853982e-01 0.314 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 4.853982e-01 0.314 0 0
NADPH regeneration R-HSA-389542 4.853982e-01 0.314 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.853982e-01 0.314 0 0
Potential therapeutics for SARS R-HSA-9679191 4.854788e-01 0.314 0 0
Translesion synthesis by POLI R-HSA-5656121 4.905166e-01 0.309 0 0
Phosphorylation of the APC/C R-HSA-176412 4.905166e-01 0.309 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.905166e-01 0.309 0 0
Differentiation of T cells R-HSA-9945266 4.905166e-01 0.309 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.905166e-01 0.309 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.918533e-01 0.308 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.918533e-01 0.308 0 0
G protein gated Potassium channels R-HSA-1296059 4.918533e-01 0.308 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.918533e-01 0.308 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.927447e-01 0.307 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.038399e-01 0.298 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.048960e-01 0.297 0 0
EGFR downregulation R-HSA-182971 5.062678e-01 0.296 0 0
G-protein activation R-HSA-202040 5.082038e-01 0.294 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.082038e-01 0.294 0 0
Lagging Strand Synthesis R-HSA-69186 5.082038e-01 0.294 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.082038e-01 0.294 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.082038e-01 0.294 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.113414e-01 0.291 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.113414e-01 0.291 0 0
ERKs are inactivated R-HSA-202670 5.113414e-01 0.291 0 0
Integration of provirus R-HSA-162592 5.113414e-01 0.291 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.113414e-01 0.291 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.139804e-01 0.289 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.143332e-01 0.289 1 1
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 5.158792e-01 0.287 0 0
Regulation of cortical dendrite branching R-HSA-8985801 5.158792e-01 0.287 0 0
Signalling to ERK5 R-HSA-198765 5.158792e-01 0.287 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 5.158792e-01 0.287 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 5.158792e-01 0.287 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 5.158792e-01 0.287 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 5.158792e-01 0.287 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 5.158792e-01 0.287 0 0
Potassium transport channels R-HSA-1296067 5.158792e-01 0.287 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 5.158792e-01 0.287 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 5.158792e-01 0.287 0 0
Defective visual phototransduction due to STRA6 loss of function R-HSA-9918449 5.158792e-01 0.287 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 5.158792e-01 0.287 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 5.158792e-01 0.287 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 5.158792e-01 0.287 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 5.158792e-01 0.287 0 0
The AIM2 inflammasome R-HSA-844615 5.158792e-01 0.287 0 0
G1/S-Specific Transcription R-HSA-69205 5.185583e-01 0.285 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.185583e-01 0.285 0 0
Translesion synthesis by POLK R-HSA-5655862 5.282553e-01 0.277 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.282553e-01 0.277 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.293217e-01 0.276 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.349610e-01 0.272 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.389339e-01 0.268 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.397991e-01 0.268 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.411913e-01 0.267 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 5.411913e-01 0.267 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.411913e-01 0.267 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 5.411913e-01 0.267 0 0
Recycling of eIF2:GDP R-HSA-72731 5.411913e-01 0.267 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.411913e-01 0.267 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.411913e-01 0.267 0 0
Ca2+ activated K+ channels R-HSA-1296052 5.411913e-01 0.267 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.411913e-01 0.267 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.411913e-01 0.267 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.412038e-01 0.267 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.412038e-01 0.267 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.442407e-01 0.264 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.442407e-01 0.264 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.455001e-01 0.263 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.476467e-01 0.261 0 0
Nucleotide Excision Repair R-HSA-5696398 5.480266e-01 0.261 0 0
COPII-mediated vesicle transport R-HSA-204005 5.510191e-01 0.259 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.510191e-01 0.259 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.519060e-01 0.258 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.519060e-01 0.258 0 0
Insulin processing R-HSA-264876 5.519060e-01 0.258 0 0
Activation of GABAB receptors R-HSA-991365 5.533106e-01 0.257 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.533106e-01 0.257 0 0
GABA B receptor activation R-HSA-977444 5.533106e-01 0.257 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.544464e-01 0.256 0 0
Maple Syrup Urine Disease R-HSA-9865114 5.544464e-01 0.256 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.544464e-01 0.256 0 0
Interleukin-35 Signalling R-HSA-8984722 5.544464e-01 0.256 0 0
Signaling by LTK R-HSA-9842663 5.544464e-01 0.256 0 0
Extension of Telomeres R-HSA-180786 5.556365e-01 0.255 0 0
Parasite infection R-HSA-9664407 5.606002e-01 0.251 0 0
Leishmania phagocytosis R-HSA-9664417 5.606002e-01 0.251 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.606002e-01 0.251 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.611489e-01 0.251 0 0
Gluconeogenesis R-HSA-70263 5.615080e-01 0.251 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.645728e-01 0.248 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.645728e-01 0.248 0 0
Inositol phosphate metabolism R-HSA-1483249 5.694306e-01 0.245 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.731284e-01 0.242 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.731284e-01 0.242 0 0
LDL clearance R-HSA-8964038 5.731284e-01 0.242 0 0
Adipogenesis R-HSA-9843745 5.770403e-01 0.239 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.806865e-01 0.236 0 0
Telomere Extension By Telomerase R-HSA-171319 5.806865e-01 0.236 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.836214e-01 0.234 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.836214e-01 0.234 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.875336e-01 0.231 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.926389e-01 0.227 0 0
FGFR1b ligand binding and activation R-HSA-190370 5.926389e-01 0.227 0 0
Activation of RAS in B cells R-HSA-1169092 5.926389e-01 0.227 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.926389e-01 0.227 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.926389e-01 0.227 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.926389e-01 0.227 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 5.926389e-01 0.227 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 5.926389e-01 0.227 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.926389e-01 0.227 0 0
Interleukin-23 signaling R-HSA-9020933 5.926389e-01 0.227 0 0
Co-stimulation by ICOS R-HSA-9927354 5.926389e-01 0.227 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.926389e-01 0.227 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.926389e-01 0.227 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.926389e-01 0.227 0 0
Developmental Cell Lineages R-HSA-9734767 5.927343e-01 0.227 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.938378e-01 0.226 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.938378e-01 0.226 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.951954e-01 0.225 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.951954e-01 0.225 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.951954e-01 0.225 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.951954e-01 0.225 0 0
MET activates STAT3 R-HSA-8875791 5.961873e-01 0.225 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.961873e-01 0.225 0 0
Axonal growth stimulation R-HSA-209563 5.961873e-01 0.225 0 0
Invadopodia formation R-HSA-8941237 5.961873e-01 0.225 0 0
Defective ABCA1 causes TGD R-HSA-5682113 5.961873e-01 0.225 0 0
Signalling to STAT3 R-HSA-198745 5.961873e-01 0.225 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.961873e-01 0.225 0 0
Defective MAOA causes BRUNS R-HSA-5579012 5.961873e-01 0.225 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 5.961873e-01 0.225 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.961873e-01 0.225 0 0
Defective CYP7B1 causes SPG5A and CBAS3 R-HSA-5579013 5.961873e-01 0.225 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.961873e-01 0.225 0 0
MET interacts with TNS proteins R-HSA-8875513 5.961873e-01 0.225 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.961873e-01 0.225 0 0
The IPAF inflammasome R-HSA-844623 5.961873e-01 0.225 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.961873e-01 0.225 0 0
Histamine receptors R-HSA-390650 5.961873e-01 0.225 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.992958e-01 0.222 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.038493e-01 0.219 0 0
Interleukin-20 family signaling R-HSA-8854691 6.038493e-01 0.219 0 0
Signaling by Erythropoietin R-HSA-9006335 6.084980e-01 0.216 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.084980e-01 0.216 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.084980e-01 0.216 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.084980e-01 0.216 0 0
Signaling by EGFR R-HSA-177929 6.104346e-01 0.214 0 0
Metabolism of RNA R-HSA-8953854 6.162829e-01 0.210 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.176134e-01 0.209 0 0
Attenuation phase R-HSA-3371568 6.176134e-01 0.209 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.176134e-01 0.209 0 0
Generation of second messenger molecules R-HSA-202433 6.176134e-01 0.209 0 0
rRNA processing R-HSA-72312 6.200820e-01 0.208 0 0
PPARA activates gene expression R-HSA-1989781 6.215160e-01 0.207 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.220024e-01 0.206 0 0
Signaling by ERBB4 R-HSA-1236394 6.246411e-01 0.204 0 0
Signaling by NOTCH4 R-HSA-9013694 6.246411e-01 0.204 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.256527e-01 0.204 0 0
Regulation of signaling by CBL R-HSA-912631 6.322975e-01 0.199 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.322975e-01 0.199 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.331778e-01 0.198 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.332662e-01 0.198 0 0
Deadenylation of mRNA R-HSA-429947 6.332662e-01 0.198 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.334340e-01 0.198 0 0
Removal of the Flap Intermediate R-HSA-69166 6.334340e-01 0.198 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.334340e-01 0.198 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.334340e-01 0.198 0 0
Malate-aspartate shuttle R-HSA-9856872 6.334340e-01 0.198 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.352600e-01 0.197 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.352600e-01 0.197 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.396474e-01 0.194 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.396474e-01 0.194 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.396474e-01 0.194 0 0
WNT mediated activation of DVL R-HSA-201688 6.396474e-01 0.194 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.396474e-01 0.194 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.396474e-01 0.194 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.396474e-01 0.194 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.396474e-01 0.194 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 6.396474e-01 0.194 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.396474e-01 0.194 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.396474e-01 0.194 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.396474e-01 0.194 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.436284e-01 0.191 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.449184e-01 0.190 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.457206e-01 0.190 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.457940e-01 0.190 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.467103e-01 0.189 0 0
Dual incision in TC-NER R-HSA-6782135 6.498283e-01 0.187 0 0
G alpha (q) signalling events R-HSA-416476 6.564489e-01 0.183 0 0
Cargo concentration in the ER R-HSA-5694530 6.609099e-01 0.180 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.609099e-01 0.180 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.613049e-01 0.180 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.613049e-01 0.180 0 0
Intra-Golgi traffic R-HSA-6811438 6.628449e-01 0.179 0 0
MTF1 activates gene expression R-HSA-5660489 6.631774e-01 0.178 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.631774e-01 0.178 0 0
HCN channels R-HSA-1296061 6.631774e-01 0.178 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.631774e-01 0.178 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 6.631774e-01 0.178 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.631774e-01 0.178 0 0
Defective MAT1A causes MATD R-HSA-5579024 6.631774e-01 0.178 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 6.631774e-01 0.178 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.631774e-01 0.178 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.631774e-01 0.178 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.631774e-01 0.178 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.631774e-01 0.178 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.631774e-01 0.178 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 6.631774e-01 0.178 0 0
Alanine metabolism R-HSA-8964540 6.631774e-01 0.178 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.631774e-01 0.178 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.631774e-01 0.178 0 0
NADE modulates death signalling R-HSA-205025 6.631774e-01 0.178 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.631774e-01 0.178 0 0
Vasopressin-like receptors R-HSA-388479 6.631774e-01 0.178 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.634927e-01 0.178 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.634927e-01 0.178 0 0
Negative regulation of MET activity R-HSA-6807004 6.634927e-01 0.178 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.634927e-01 0.178 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.634927e-01 0.178 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.665238e-01 0.176 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.665238e-01 0.176 0 0
Triglyceride metabolism R-HSA-8979227 6.686826e-01 0.175 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.690823e-01 0.175 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.690823e-01 0.175 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.690823e-01 0.175 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.690823e-01 0.175 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.690823e-01 0.175 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.690823e-01 0.175 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.690823e-01 0.175 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.690823e-01 0.175 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.690823e-01 0.175 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.690823e-01 0.175 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.690823e-01 0.175 0 0
Hedgehog 'on' state R-HSA-5632684 6.733255e-01 0.172 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 6.822738e-01 0.166 0 0
Binding and entry of HIV virion R-HSA-173107 6.822738e-01 0.166 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.822738e-01 0.166 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.822738e-01 0.166 0 0
Metabolism of serotonin R-HSA-380612 6.822738e-01 0.166 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.822738e-01 0.166 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.822738e-01 0.166 0 0
PI3K/AKT activation R-HSA-198203 6.822738e-01 0.166 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.822738e-01 0.166 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.822738e-01 0.166 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 6.822738e-01 0.166 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.822738e-01 0.166 0 0
Voltage gated Potassium channels R-HSA-1296072 6.843420e-01 0.165 0 0
DNA strand elongation R-HSA-69190 6.854014e-01 0.164 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.879149e-01 0.162 0 0
PCP/CE pathway R-HSA-4086400 6.918651e-01 0.160 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.928328e-01 0.159 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.928328e-01 0.159 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.928328e-01 0.159 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.928328e-01 0.159 0 0
Mitochondrial protein degradation R-HSA-9837999 6.976545e-01 0.156 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.021213e-01 0.154 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.021213e-01 0.154 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.021213e-01 0.154 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.021213e-01 0.154 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.021213e-01 0.154 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.045820e-01 0.152 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.047281e-01 0.152 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.063286e-01 0.151 0 0
Cardiogenesis R-HSA-9733709 7.087036e-01 0.150 0 0
Cristae formation R-HSA-8949613 7.130670e-01 0.147 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.130670e-01 0.147 0 0
Signaling by BMP R-HSA-201451 7.130670e-01 0.147 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.130670e-01 0.147 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 7.190573e-01 0.143 0 0
Activation of AMPA receptors R-HSA-399710 7.190573e-01 0.143 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 7.190573e-01 0.143 0 0
Defective F9 activation R-HSA-9673221 7.190573e-01 0.143 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.190573e-01 0.143 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 7.190573e-01 0.143 0 0
PTK6 Activates STAT3 R-HSA-8849474 7.190573e-01 0.143 0 0
Activation of AKT2 R-HSA-165158 7.190573e-01 0.143 0 0
Suppression of autophagy R-HSA-9636569 7.190573e-01 0.143 0 0
Muscarinic acetylcholine receptors R-HSA-390648 7.190573e-01 0.143 0 0
Inositol transporters R-HSA-429593 7.190573e-01 0.143 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 7.190573e-01 0.143 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 7.190573e-01 0.143 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.203006e-01 0.142 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.203006e-01 0.142 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.206780e-01 0.142 0 0
Chylomicron assembly R-HSA-8963888 7.206780e-01 0.142 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 7.206780e-01 0.142 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.206780e-01 0.142 0 0
vRNP Assembly R-HSA-192905 7.206780e-01 0.142 0 0
Transport of RCbl within the body R-HSA-9758890 7.206780e-01 0.142 0 0
Suppression of apoptosis R-HSA-9635465 7.206780e-01 0.142 0 0
LGI-ADAM interactions R-HSA-5682910 7.206780e-01 0.142 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.219246e-01 0.142 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.227849e-01 0.141 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.268869e-01 0.139 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.325806e-01 0.135 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.325806e-01 0.135 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.325806e-01 0.135 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.325806e-01 0.135 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.325806e-01 0.135 1 1
Passive transport by Aquaporins R-HSA-432047 7.325806e-01 0.135 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.367510e-01 0.133 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.367510e-01 0.133 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.459056e-01 0.127 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.459056e-01 0.127 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.459056e-01 0.127 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.459056e-01 0.127 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.459056e-01 0.127 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.466169e-01 0.127 0 0
Glycogen metabolism R-HSA-8982491 7.466169e-01 0.127 0 0
Gastrulation R-HSA-9758941 7.502793e-01 0.125 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.514790e-01 0.124 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.516836e-01 0.124 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.516836e-01 0.124 0 0
Stimuli-sensing channels R-HSA-2672351 7.528563e-01 0.123 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.550877e-01 0.122 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.550877e-01 0.122 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.550877e-01 0.122 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.550877e-01 0.122 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.550877e-01 0.122 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.550877e-01 0.122 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.576744e-01 0.121 0 0
Orc1 removal from chromatin R-HSA-68949 7.576744e-01 0.121 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.576744e-01 0.121 0 0
mRNA 3'-end processing R-HSA-72187 7.576744e-01 0.121 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.582418e-01 0.120 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.589729e-01 0.120 0 0
Glucagon-type ligand receptors R-HSA-420092 7.589729e-01 0.120 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.605277e-01 0.119 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.605277e-01 0.119 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.605277e-01 0.119 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.605277e-01 0.119 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.605277e-01 0.119 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.605277e-01 0.119 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.609014e-01 0.119 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.653145e-01 0.116 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.656693e-01 0.116 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.656693e-01 0.116 0 0
Cam-PDE 1 activation R-HSA-111957 7.656693e-01 0.116 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.656693e-01 0.116 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.656693e-01 0.116 0 0
Terminal pathway of complement R-HSA-166665 7.656693e-01 0.116 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.656693e-01 0.116 0 0
NGF-independant TRKA activation R-HSA-187024 7.656693e-01 0.116 0 0
Phosphorylation of Emi1 R-HSA-176417 7.656693e-01 0.116 0 0
Formation of the Editosome R-HSA-75094 7.656693e-01 0.116 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 7.656693e-01 0.116 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.656693e-01 0.116 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 7.656693e-01 0.116 0 0
VEGF ligand-receptor interactions R-HSA-194313 7.656693e-01 0.116 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.656693e-01 0.116 0 0
HIV Life Cycle R-HSA-162587 7.713408e-01 0.113 0 0
HCMV Late Events R-HSA-9610379 7.713408e-01 0.113 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.715199e-01 0.113 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.767091e-01 0.110 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.778261e-01 0.109 0 0
DAP12 signaling R-HSA-2424491 7.797526e-01 0.108 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.797526e-01 0.108 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.797526e-01 0.108 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.797526e-01 0.108 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.808006e-01 0.107 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.857711e-01 0.105 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.857711e-01 0.105 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.857711e-01 0.105 0 0
MET activates RAS signaling R-HSA-8851805 7.857711e-01 0.105 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.857711e-01 0.105 0 0
OAS antiviral response R-HSA-8983711 7.857711e-01 0.105 0 0
GABA receptor activation R-HSA-977443 7.858653e-01 0.105 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.860587e-01 0.105 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.860587e-01 0.105 0 0
Mismatch Repair R-HSA-5358508 7.860587e-01 0.105 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.898520e-01 0.102 0 0
RNA Polymerase III Transcription R-HSA-74158 7.898520e-01 0.102 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.898520e-01 0.102 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.916708e-01 0.101 0 0
NGF-stimulated transcription R-HSA-9031628 7.938585e-01 0.100 0 0
Circadian clock R-HSA-9909396 7.974009e-01 0.098 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.991220e-01 0.097 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 8.045499e-01 0.094 0 0
Signaling by LTK in cancer R-HSA-9842640 8.045499e-01 0.094 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 8.045499e-01 0.094 0 0
STAT5 Activation R-HSA-9645135 8.045499e-01 0.094 0 0
Autointegration results in viral DNA circles R-HSA-177539 8.045499e-01 0.094 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 8.045499e-01 0.094 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 8.045499e-01 0.094 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 8.045499e-01 0.094 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 8.045499e-01 0.094 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 8.045499e-01 0.094 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 8.045499e-01 0.094 0 0
Neurofascin interactions R-HSA-447043 8.045499e-01 0.094 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 8.045499e-01 0.094 0 0
Synthesis of dolichyl-phosphate-glucose R-HSA-480985 8.045499e-01 0.094 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 8.045499e-01 0.094 0 0
Metabolism of vitamin K R-HSA-6806664 8.045499e-01 0.094 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 8.045499e-01 0.094 0 0
HDL clearance R-HSA-8964011 8.045499e-01 0.094 0 0
VLDL assembly R-HSA-8866423 8.045499e-01 0.094 0 0
CREB3 factors activate genes R-HSA-8874211 8.045499e-01 0.094 0 0
Signaling by FGFR in disease R-HSA-1226099 8.071089e-01 0.093 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.071754e-01 0.093 0 0
Degradation of DVL R-HSA-4641258 8.071754e-01 0.093 0 0
Synthesis of DNA R-HSA-69239 8.090184e-01 0.092 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.092900e-01 0.092 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.092900e-01 0.092 0 0
Specification of the neural plate border R-HSA-9834899 8.092900e-01 0.092 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.092900e-01 0.092 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.119436e-01 0.090 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.130172e-01 0.090 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.130172e-01 0.090 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.130172e-01 0.090 0 0
Chylomicron remodeling R-HSA-8963901 8.130172e-01 0.090 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.130172e-01 0.090 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.130172e-01 0.090 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.130172e-01 0.090 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.130172e-01 0.090 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.130172e-01 0.090 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.130172e-01 0.090 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.130172e-01 0.090 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.135424e-01 0.090 0 0
Signaling by FGFR4 R-HSA-5654743 8.153132e-01 0.089 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.171224e-01 0.088 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.191636e-01 0.087 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.233632e-01 0.084 0 0
Pyruvate metabolism R-HSA-70268 8.254943e-01 0.083 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.300118e-01 0.081 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.303520e-01 0.081 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.303520e-01 0.081 0 0
Protein hydroxylation R-HSA-9629569 8.303520e-01 0.081 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.305714e-01 0.081 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.305714e-01 0.081 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.305714e-01 0.081 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.338029e-01 0.079 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.367466e-01 0.077 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.369812e-01 0.077 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 8.369812e-01 0.077 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 8.369812e-01 0.077 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 8.369812e-01 0.077 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.369812e-01 0.077 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 8.369812e-01 0.077 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 8.369812e-01 0.077 0 0
mRNA Editing: C to U Conversion R-HSA-72200 8.369812e-01 0.077 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 8.369812e-01 0.077 0 0
LDL remodeling R-HSA-8964041 8.369812e-01 0.077 0 0
Activation of TRKA receptors R-HSA-187015 8.369812e-01 0.077 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 8.369812e-01 0.077 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 8.369812e-01 0.077 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.371218e-01 0.077 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.371218e-01 0.077 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.371218e-01 0.077 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.371218e-01 0.077 0 0
Pentose phosphate pathway R-HSA-71336 8.384517e-01 0.077 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.384517e-01 0.077 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.387153e-01 0.076 0 0
Translation of Structural Proteins R-HSA-9694635 8.418432e-01 0.075 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.437705e-01 0.074 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.437705e-01 0.074 0 0
ER-Phagosome pathway R-HSA-1236974 8.461323e-01 0.073 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.492183e-01 0.071 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.492183e-01 0.071 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.493741e-01 0.071 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.493741e-01 0.071 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.493835e-01 0.071 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.493835e-01 0.071 0 0
Cellular response to hypoxia R-HSA-1234174 8.498857e-01 0.071 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.524812e-01 0.069 0 0
Peroxisomal protein import R-HSA-9033241 8.550514e-01 0.068 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.566212e-01 0.067 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.566212e-01 0.067 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.583772e-01 0.066 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.583772e-01 0.066 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.583772e-01 0.066 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.583772e-01 0.066 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.583772e-01 0.066 0 0
Biotin transport and metabolism R-HSA-196780 8.583772e-01 0.066 0 0
Other semaphorin interactions R-HSA-416700 8.583772e-01 0.066 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.612090e-01 0.065 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.634280e-01 0.064 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.640327e-01 0.063 0 0
phospho-PLA2 pathway R-HSA-111995 8.640327e-01 0.063 0 0
MET receptor recycling R-HSA-8875656 8.640327e-01 0.063 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 8.640327e-01 0.063 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.640327e-01 0.063 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.640327e-01 0.063 0 0
Fructose biosynthesis R-HSA-5652227 8.640327e-01 0.063 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.640327e-01 0.063 0 0
Sodium/Proton exchangers R-HSA-425986 8.640327e-01 0.063 0 0
Alpha-defensins R-HSA-1462054 8.640327e-01 0.063 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.654960e-01 0.063 0 0
Maturation of spike protein R-HSA-9694548 8.654960e-01 0.063 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.665270e-01 0.062 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.665270e-01 0.062 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.665270e-01 0.062 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.665270e-01 0.062 0 0
Signaling by MET R-HSA-6806834 8.715561e-01 0.060 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.722796e-01 0.059 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.762719e-01 0.057 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.762719e-01 0.057 0 0
Regulation of Apoptosis R-HSA-169911 8.764942e-01 0.057 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.767375e-01 0.057 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.770650e-01 0.057 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.770650e-01 0.057 0 0
Activation of SMO R-HSA-5635838 8.770650e-01 0.057 0 0
Attachment and Entry R-HSA-9678110 8.770650e-01 0.057 0 0
Regulation of BACH1 activity R-HSA-9708530 8.770650e-01 0.057 0 0
Negative regulation of FLT3 R-HSA-9706369 8.770650e-01 0.057 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 8.770650e-01 0.057 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.774243e-01 0.057 0 0
Translation of Structural Proteins R-HSA-9683701 8.775425e-01 0.057 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.817301e-01 0.055 0 0
Ethanol oxidation R-HSA-71384 8.819257e-01 0.055 0 0
Mitochondrial protein import R-HSA-1268020 8.858912e-01 0.053 0 0
Signaling by PDGF R-HSA-186797 8.858912e-01 0.053 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.865965e-01 0.052 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.865965e-01 0.052 0 0
Calcineurin activates NFAT R-HSA-2025928 8.865965e-01 0.052 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.865965e-01 0.052 0 0
Unwinding of DNA R-HSA-176974 8.865965e-01 0.052 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 8.865965e-01 0.052 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 8.865965e-01 0.052 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.865965e-01 0.052 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.865965e-01 0.052 0 0
FLT3 signaling in disease R-HSA-9682385 8.884808e-01 0.051 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.886688e-01 0.051 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.895147e-01 0.051 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.903285e-01 0.050 0 0
Neurotransmitter clearance R-HSA-112311 8.903285e-01 0.050 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.912406e-01 0.050 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.926293e-01 0.049 0 0
Phase 2 - plateau phase R-HSA-5576893 8.934520e-01 0.049 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.934520e-01 0.049 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.934520e-01 0.049 0 0
Glycine degradation R-HSA-6783984 8.934520e-01 0.049 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.934520e-01 0.049 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.934520e-01 0.049 0 0
Galactose catabolism R-HSA-70370 8.934520e-01 0.049 0 0
Synthesis of PG R-HSA-1483148 8.934520e-01 0.049 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.934520e-01 0.049 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.934520e-01 0.049 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.957205e-01 0.048 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.957205e-01 0.048 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.957205e-01 0.048 0 0
Degradation of AXIN R-HSA-4641257 8.994527e-01 0.046 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.994527e-01 0.046 0 0
PI3K Cascade R-HSA-109704 8.996648e-01 0.046 0 0
IRS-mediated signalling R-HSA-112399 9.012127e-01 0.045 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.020266e-01 0.045 0 0
Budding and maturation of HIV virion R-HSA-162588 9.020266e-01 0.045 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.020266e-01 0.045 0 0
IGF1R signaling cascade R-HSA-2428924 9.032797e-01 0.044 0 0
OADH complex synthesizes glutaryl-CoA from 2-OA R-HSA-9858328 9.054169e-01 0.043 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 9.054169e-01 0.043 0 0
Regulation of the apoptosome activity R-HSA-9627069 9.054169e-01 0.043 0 0
Formation of apoptosome R-HSA-111458 9.054169e-01 0.043 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 9.054169e-01 0.043 0 0
CASP4 inflammasome assembly R-HSA-9948001 9.054169e-01 0.043 0 0
Formation of intermediate mesoderm R-HSA-9761174 9.054169e-01 0.043 0 0
Arachidonate production from DAG R-HSA-426048 9.054169e-01 0.043 0 0
Maturation of spike protein R-HSA-9683686 9.054169e-01 0.043 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 9.054169e-01 0.043 0 0
Sperm Motility And Taxes R-HSA-1300642 9.054169e-01 0.043 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 9.054169e-01 0.043 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 9.054169e-01 0.043 0 0
Josephin domain DUBs R-HSA-5689877 9.054169e-01 0.043 0 0
Serotonin receptors R-HSA-390666 9.054169e-01 0.043 0 0
Neurotransmitter release cycle R-HSA-112310 9.072334e-01 0.042 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.077870e-01 0.042 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.077870e-01 0.042 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.077870e-01 0.042 0 0
Proteasome assembly R-HSA-9907900 9.083586e-01 0.042 0 0
DAP12 interactions R-HSA-2172127 9.083586e-01 0.042 0 0
MET promotes cell motility R-HSA-8875878 9.094744e-01 0.041 0 0
Elastic fibre formation R-HSA-1566948 9.094744e-01 0.041 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.111034e-01 0.040 0 0
GPCR downstream signalling R-HSA-388396 9.112735e-01 0.040 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.170208e-01 0.038 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.170208e-01 0.038 0 0
Signaling by FGFR3 R-HSA-5654741 9.170208e-01 0.038 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.172567e-01 0.038 0 0
G alpha (s) signalling events R-HSA-418555 9.179387e-01 0.037 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.183837e-01 0.037 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.186095e-01 0.037 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.186095e-01 0.037 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.190383e-01 0.037 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.190383e-01 0.037 0 0
GAB1 signalosome R-HSA-180292 9.202996e-01 0.036 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.202996e-01 0.036 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.202996e-01 0.036 0 0
Tie2 Signaling R-HSA-210993 9.202996e-01 0.036 0 0
Nephron development R-HSA-9831926 9.202996e-01 0.036 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.202996e-01 0.036 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 9.211148e-01 0.036 0 0
FGFR2b ligand binding and activation R-HSA-190377 9.211148e-01 0.036 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 9.211148e-01 0.036 0 0
Conjugation of benzoate with glycine R-HSA-177135 9.211148e-01 0.036 0 0
vRNA Synthesis R-HSA-192814 9.211148e-01 0.036 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 9.211148e-01 0.036 0 0
Synthesis of PI R-HSA-1483226 9.211148e-01 0.036 0 0
Bicarbonate transporters R-HSA-425381 9.211148e-01 0.036 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 9.211148e-01 0.036 0 0
Prostanoid ligand receptors R-HSA-391908 9.211148e-01 0.036 0 0
Dissolution of Fibrin Clot R-HSA-75205 9.211148e-01 0.036 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.263083e-01 0.033 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.269204e-01 0.033 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.269204e-01 0.033 0 0
HIV Transcription Elongation R-HSA-167169 9.269204e-01 0.033 0 0
MET activates PTK2 signaling R-HSA-8874081 9.288159e-01 0.032 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.288159e-01 0.032 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.288159e-01 0.032 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.288159e-01 0.032 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.310093e-01 0.031 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.311999e-01 0.031 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.311999e-01 0.031 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.311999e-01 0.031 0 0
Diseases of hemostasis R-HSA-9671793 9.311999e-01 0.031 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.311999e-01 0.031 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.311999e-01 0.031 0 0
Translation R-HSA-72766 9.323695e-01 0.030 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.333979e-01 0.030 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.342080e-01 0.030 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 9.342080e-01 0.030 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 9.342080e-01 0.030 0 0
Plasmalogen biosynthesis R-HSA-75896 9.342080e-01 0.030 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 9.342080e-01 0.030 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 9.342080e-01 0.030 0 0
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-141333 9.342080e-01 0.030 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 9.342080e-01 0.030 0 0
Sodium/Calcium exchangers R-HSA-425561 9.342080e-01 0.030 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 9.342080e-01 0.030 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.344674e-01 0.029 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.374966e-01 0.028 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.374966e-01 0.028 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.374966e-01 0.028 0 0
eNOS activation R-HSA-203615 9.384907e-01 0.028 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.384907e-01 0.028 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.406782e-01 0.027 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.406782e-01 0.027 0 0
Infectious disease R-HSA-5663205 9.417061e-01 0.026 1 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.418244e-01 0.026 0 0
Protein localization R-HSA-9609507 9.433775e-01 0.025 0 0
Signaling by FGFR1 R-HSA-5654736 9.434164e-01 0.025 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 9.451287e-01 0.025 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 9.451287e-01 0.025 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.451287e-01 0.025 0 0
Acetylation R-HSA-156582 9.451287e-01 0.025 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.451287e-01 0.025 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.451287e-01 0.025 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.451287e-01 0.025 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 9.451287e-01 0.025 0 0
Estrogen biosynthesis R-HSA-193144 9.451287e-01 0.025 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.451287e-01 0.025 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.451889e-01 0.024 0 0
HIV elongation arrest and recovery R-HSA-167287 9.451889e-01 0.024 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.451889e-01 0.024 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.454290e-01 0.024 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.454290e-01 0.024 0 0
Insulin receptor signalling cascade R-HSA-74751 9.478974e-01 0.023 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.489063e-01 0.023 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.489063e-01 0.023 0 0
Basigin interactions R-HSA-210991 9.489063e-01 0.023 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.489063e-01 0.023 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.516439e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.518017e-01 0.021 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.519932e-01 0.021 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.519932e-01 0.021 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.530915e-01 0.021 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 9.542372e-01 0.020 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.542372e-01 0.020 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.542372e-01 0.020 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.542372e-01 0.020 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.542372e-01 0.020 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.542372e-01 0.020 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.542372e-01 0.020 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.542372e-01 0.020 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.542372e-01 0.020 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.554180e-01 0.020 0 0
Attachment and Entry R-HSA-9694614 9.560379e-01 0.020 0 0
Assembly Of The HIV Virion R-HSA-175474 9.560379e-01 0.020 0 0
Ribavirin ADME R-HSA-9755088 9.560379e-01 0.020 0 0
Metabolism of folate and pterines R-HSA-196757 9.572015e-01 0.019 0 0
tRNA processing R-HSA-72306 9.590232e-01 0.018 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.603161e-01 0.018 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.618341e-01 0.017 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.618341e-01 0.017 0 0
Hydrolysis of LPC R-HSA-1483115 9.618341e-01 0.017 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.618341e-01 0.017 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.618341e-01 0.017 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.618341e-01 0.017 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.618341e-01 0.017 0 0
Physiological factors R-HSA-5578768 9.618341e-01 0.017 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.618341e-01 0.017 0 0
Zinc transporters R-HSA-435354 9.618341e-01 0.017 0 0
FGFR2 alternative splicing R-HSA-6803529 9.622102e-01 0.017 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.622102e-01 0.017 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.622102e-01 0.017 0 0
Fructose metabolism R-HSA-5652084 9.622102e-01 0.017 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.622102e-01 0.017 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.622252e-01 0.017 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.622252e-01 0.017 0 0
Somitogenesis R-HSA-9824272 9.626792e-01 0.017 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.632990e-01 0.016 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.640801e-01 0.016 0 0
Disease R-HSA-1643685 9.645610e-01 0.016 1 0
Leishmania parasite growth and survival R-HSA-9664433 9.662178e-01 0.015 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.662178e-01 0.015 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.667649e-01 0.015 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.675453e-01 0.014 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.675453e-01 0.014 0 0
Carnitine shuttle R-HSA-200425 9.675453e-01 0.014 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.675453e-01 0.014 0 0
Protein lipoylation R-HSA-9857492 9.681703e-01 0.014 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.681703e-01 0.014 0 0
Protein repair R-HSA-5676934 9.681703e-01 0.014 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.681703e-01 0.014 0 0
DNA Damage Reversal R-HSA-73942 9.681703e-01 0.014 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.705242e-01 0.013 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.721509e-01 0.012 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.721509e-01 0.012 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.721509e-01 0.012 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 9.734548e-01 0.012 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.734548e-01 0.012 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.734548e-01 0.012 0 0
Fructose catabolism R-HSA-70350 9.734548e-01 0.012 0 0
Carnitine synthesis R-HSA-71262 9.734548e-01 0.012 0 0
The retinoid cycle in cones (daylight vision) R-HSA-2187335 9.734548e-01 0.012 0 0
Metabolism of cofactors R-HSA-8978934 9.738631e-01 0.012 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.740242e-01 0.011 0 0
Heme degradation R-HSA-189483 9.756598e-01 0.011 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.761221e-01 0.010 0 0
Laminin interactions R-HSA-3000157 9.761221e-01 0.010 0 0
Formation of the nephric duct R-HSA-9830364 9.761221e-01 0.010 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.761221e-01 0.010 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.771311e-01 0.010 0 0
HIV Transcription Initiation R-HSA-167161 9.771311e-01 0.010 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.771311e-01 0.010 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.771311e-01 0.010 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.771311e-01 0.010 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.778623e-01 0.010 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.778623e-01 0.010 0 0
Fibronectin matrix formation R-HSA-1566977 9.778623e-01 0.010 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.778623e-01 0.010 0 0
Heme assimilation R-HSA-9927020 9.778623e-01 0.010 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.778623e-01 0.010 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.778623e-01 0.010 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.778623e-01 0.010 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.778623e-01 0.010 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.778623e-01 0.010 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 9.778623e-01 0.010 0 0
Response to metal ions R-HSA-5660526 9.778623e-01 0.010 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.788146e-01 0.009 0 0
Signaling by NOTCH2 R-HSA-1980145 9.788146e-01 0.009 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.788146e-01 0.009 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.788146e-01 0.009 0 0
RA biosynthesis pathway R-HSA-5365859 9.788146e-01 0.009 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.794320e-01 0.009 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.815381e-01 0.008 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.815381e-01 0.008 0 0
Choline catabolism R-HSA-6798163 9.815381e-01 0.008 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.815771e-01 0.008 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.815771e-01 0.008 0 0
PERK regulates gene expression R-HSA-381042 9.815771e-01 0.008 0 0
The phototransduction cascade R-HSA-2514856 9.816634e-01 0.008 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.823248e-01 0.008 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.824858e-01 0.008 0 0
Triglyceride biosynthesis R-HSA-75109 9.824858e-01 0.008 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.824858e-01 0.008 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.830878e-01 0.007 0 0
tRNA Aminoacylation R-HSA-379724 9.836498e-01 0.007 0 0
Transcription of the HIV genome R-HSA-167172 9.839272e-01 0.007 0 0
G alpha (i) signalling events R-HSA-418594 9.843129e-01 0.007 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.846038e-01 0.007 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.846038e-01 0.007 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.846038e-01 0.007 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.846038e-01 0.007 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.850158e-01 0.007 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.850158e-01 0.007 0 0
Nucleotide biosynthesis R-HSA-8956320 9.856387e-01 0.006 0 0
Lysine catabolism R-HSA-71064 9.861039e-01 0.006 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.861039e-01 0.006 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.863876e-01 0.006 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.871605e-01 0.006 0 0
Pyrimidine biosynthesis R-HSA-500753 9.871605e-01 0.006 0 0
Conjugation of carboxylic acids R-HSA-159424 9.871605e-01 0.006 0 0
Amino Acid conjugation R-HSA-156587 9.871605e-01 0.006 0 0
Amine Oxidase reactions R-HSA-140179 9.871605e-01 0.006 0 0
mRNA Capping R-HSA-72086 9.871887e-01 0.006 0 0
Thyroxine biosynthesis R-HSA-209968 9.871887e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.874452e-01 0.005 0 0
ABC transporter disorders R-HSA-5619084 9.874452e-01 0.005 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.879552e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.880153e-01 0.005 0 0
Neddylation R-HSA-8951664 9.884813e-01 0.005 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.884854e-01 0.005 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.892928e-01 0.005 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.892928e-01 0.005 0 0
Keratan sulfate degradation R-HSA-2022857 9.892928e-01 0.005 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.892928e-01 0.005 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.892928e-01 0.005 0 0
Creatine metabolism R-HSA-71288 9.892928e-01 0.005 0 0
Pregnenolone biosynthesis R-HSA-196108 9.892928e-01 0.005 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.892928e-01 0.005 0 0
Glycogen synthesis R-HSA-3322077 9.892928e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.895517e-01 0.005 0 0
RAS processing R-HSA-9648002 9.895517e-01 0.005 0 0
Signaling by GPCR R-HSA-372790 9.896325e-01 0.005 0 0
Signaling by FGFR2 R-HSA-5654738 9.898908e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.900986e-01 0.004 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.906520e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.908570e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.909504e-01 0.004 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.910711e-01 0.004 0 0
Phenylalanine metabolism R-HSA-8964208 9.910711e-01 0.004 0 0
Abacavir metabolism R-HSA-2161541 9.910711e-01 0.004 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.910711e-01 0.004 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.910711e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.912785e-01 0.004 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.920054e-01 0.003 0 0
Eicosanoids R-HSA-211979 9.925541e-01 0.003 0 0
Miscellaneous substrates R-HSA-211958 9.925541e-01 0.003 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.925541e-01 0.003 0 0
Serine metabolism R-HSA-977347 9.925541e-01 0.003 0 0
Glutathione synthesis and recycling R-HSA-174403 9.925541e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.927314e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.927361e-01 0.003 0 0
Azathioprine ADME R-HSA-9748787 9.930148e-01 0.003 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.931945e-01 0.003 0 0
Phospholipid metabolism R-HSA-1483257 9.932238e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.932351e-01 0.003 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 9.937909e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.940038e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.940486e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.941443e-01 0.003 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.941979e-01 0.003 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.941979e-01 0.003 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.942684e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.943764e-01 0.002 0 0
Signaling by FGFR R-HSA-190236 9.943959e-01 0.002 0 0
Fatty acids R-HSA-211935 9.948223e-01 0.002 0 0
Biosynthesis of maresins R-HSA-9018682 9.948223e-01 0.002 0 0
Formation of the ureteric bud R-HSA-9830674 9.948223e-01 0.002 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.948223e-01 0.002 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.948223e-01 0.002 0 0
Ketone body metabolism R-HSA-74182 9.948223e-01 0.002 0 0
Signaling by Insulin receptor R-HSA-74752 9.948509e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.950557e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.950557e-01 0.002 0 0
Interferon gamma signaling R-HSA-877300 9.951924e-01 0.002 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.954036e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.955431e-01 0.002 0 0
CYP2E1 reactions R-HSA-211999 9.956824e-01 0.002 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.956824e-01 0.002 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.956824e-01 0.002 0 0
Complex III assembly R-HSA-9865881 9.956824e-01 0.002 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.956824e-01 0.002 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.956824e-01 0.002 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.957887e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.957887e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.961409e-01 0.002 0 0
Hyaluronan degradation R-HSA-2160916 9.963997e-01 0.002 0 0
Fertilization R-HSA-1187000 9.963997e-01 0.002 0 0
Retinoid cycle disease events R-HSA-2453864 9.963997e-01 0.002 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.963997e-01 0.002 0 0
Diseases of the neuronal system R-HSA-9675143 9.963997e-01 0.002 0 0
Diseases associated with visual transduction R-HSA-2474795 9.963997e-01 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 9.964147e-01 0.002 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.964596e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.964795e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.965389e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.969490e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.969960e-01 0.001 0 0
Urea cycle R-HSA-70635 9.969978e-01 0.001 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.969978e-01 0.001 0 0
Abacavir ADME R-HSA-2161522 9.969978e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.970800e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.973355e-01 0.001 0 0
Purine salvage R-HSA-74217 9.974047e-01 0.001 0 0
Synthesis of PE R-HSA-1483213 9.974966e-01 0.001 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.974966e-01 0.001 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.974966e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.975891e-01 0.001 0 0
Kidney development R-HSA-9830369 9.976181e-01 0.001 0 0
Insulin receptor recycling R-HSA-77387 9.979126e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.979246e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.979246e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.981151e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.981244e-01 0.001 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.982143e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.983810e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.984644e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.984839e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.986075e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.987831e-01 0.001 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.987899e-01 0.001 0 0
Keratan sulfate biosynthesis R-HSA-2022854 9.991587e-01 0.000 0 0
Nuclear RNA decay R-HSA-9930044 9.991587e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.991724e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.991724e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.991724e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.991930e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.992980e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.992980e-01 0.000 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.992985e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.993598e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.993598e-01 0.000 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.994151e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994464e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.994657e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.994668e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.994954e-01 0.000 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.995124e-01 0.000 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.995124e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.995361e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.995361e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.995480e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.995785e-01 0.000 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.995934e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.996128e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.996213e-01 0.000 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.996610e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.996610e-01 0.000 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.996610e-01 0.000 0 0
Collagen chain trimerization R-HSA-8948216 9.996610e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996685e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.996931e-01 0.000 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.997174e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.997174e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.997706e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998022e-01 0.000 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.998035e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.998171e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.998635e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998735e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998873e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998891e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.998944e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998944e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.998968e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.999051e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.999051e-01 0.000 0 0
Defensins R-HSA-1461973 9.999051e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999192e-01 0.000 0 0
Methylation R-HSA-156581 9.999209e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999310e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999310e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.999340e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.999340e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999514e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.999514e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999527e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.999542e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999675e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.999681e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999706e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999707e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999824e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999861e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999886e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999894e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999905e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999911e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999925e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999937e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999940e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999947e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.999962e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999973e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999980e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999983e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999986e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999987e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999988e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999990e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999991e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999993e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999994e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999995e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999995e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999995e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999996e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999997e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999997e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999998e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999998e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999999e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999999e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999999e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999999e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999999e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
Initial triggering of complement R-HSA-166663 1.000000e+00 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cell Cycle Checkpoints R-HSA-69620 1.776357e-15 14.750 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.108624e-14 13.507 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.108624e-14 13.507 0 0
Metabolism of RNA R-HSA-8953854 3.375078e-14 13.472 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.815171e-14 13.055 0 0
HSF1-dependent transactivation R-HSA-3371571 1.125766e-13 12.949 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.580958e-13 12.801 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.295142e-13 12.482 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.080358e-12 11.966 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.235345e-12 11.908 0 0
Signaling by ROBO receptors R-HSA-376176 1.686651e-12 11.773 0 0
Attenuation phase R-HSA-3371568 1.857403e-12 11.731 0 0
Separation of Sister Chromatids R-HSA-2467813 2.609024e-12 11.584 0 0
Mitotic Anaphase R-HSA-68882 3.047118e-12 11.516 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.657741e-12 11.437 0 0
G2/M Checkpoints R-HSA-69481 8.800183e-12 11.056 0 0
Recycling pathway of L1 R-HSA-437239 1.346001e-11 10.871 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.331091e-11 10.876 0 0
Peptide chain elongation R-HSA-156902 1.544398e-11 10.811 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.365697e-11 10.626 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.511857e-11 10.600 0 0
HSF1 activation R-HSA-3371511 4.599687e-11 10.337 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.410073e-11 10.026 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.345747e-10 9.871 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.393085e-10 9.856 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.393085e-10 9.856 0 0
Mitotic Prophase R-HSA-68875 1.427675e-10 9.845 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.471289e-10 9.832 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.796612e-10 9.746 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.206859e-10 9.656 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.206859e-10 9.656 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.519249e-10 9.599 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.265479e-10 9.486 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.094898e-10 9.388 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.373455e-10 9.359 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.373455e-10 9.359 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.450244e-10 9.352 0 0
Signal Transduction R-HSA-162582 5.142513e-10 9.289 1 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.537291e-10 9.257 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.029298e-10 9.220 0 0
Cell junction organization R-HSA-446728 6.279796e-10 9.202 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.297144e-10 9.137 0 0
Cell-Cell communication R-HSA-1500931 7.719698e-10 9.112 0 0
Mitotic Prometaphase R-HSA-68877 7.820548e-10 9.107 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.690627e-10 9.061 0 0
Influenza Infection R-HSA-168255 1.266588e-09 8.897 0 0
Ribosome-associated quality control R-HSA-9948299 1.410423e-09 8.851 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.998229e-09 8.699 0 0
Eukaryotic Translation Termination R-HSA-72764 2.200205e-09 8.658 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.389993e-09 8.622 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.404172e-09 8.619 0 0
Selenocysteine synthesis R-HSA-2408557 2.849355e-09 8.545 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.158963e-09 8.381 0 0
DNA methylation R-HSA-5334118 5.083564e-09 8.294 0 0
L1CAM interactions R-HSA-373760 5.285955e-09 8.277 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.876040e-09 8.231 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.104044e-09 8.091 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.486407e-09 8.071 0 0
Cellular Senescence R-HSA-2559583 9.901270e-09 8.004 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.126233e-08 7.948 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.141777e-08 7.942 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.367102e-08 7.864 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.367142e-08 7.864 0 0
Viral mRNA Translation R-HSA-192823 1.409322e-08 7.851 0 0
Translation initiation complex formation R-HSA-72649 1.549745e-08 7.810 0 0
Apoptotic execution phase R-HSA-75153 1.881832e-08 7.725 0 0
Apoptosis R-HSA-109581 1.826805e-08 7.738 0 0
HDACs deacetylate histones R-HSA-3214815 2.118178e-08 7.674 0 0
Post NMDA receptor activation events R-HSA-438064 2.252271e-08 7.647 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.487961e-08 7.604 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.818082e-08 7.550 0 0
Aggrephagy R-HSA-9646399 2.985761e-08 7.525 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.876254e-08 7.541 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.985761e-08 7.525 0 0
Diseases of programmed cell death R-HSA-9645723 2.857125e-08 7.544 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.025763e-08 7.519 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.326205e-08 7.478 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.450679e-08 7.462 0 0
Adherens junctions interactions R-HSA-418990 4.200433e-08 7.377 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.663861e-08 7.247 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.376732e-08 7.195 0 0
Programmed Cell Death R-HSA-5357801 8.455372e-08 7.073 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.072602e-07 6.970 0 0
HCMV Early Events R-HSA-9609690 1.116348e-07 6.952 0 0
rRNA processing R-HSA-72312 1.213688e-07 6.916 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.298697e-07 6.886 0 0
Interleukin-12 signaling R-HSA-9020591 1.425195e-07 6.846 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.588939e-07 6.799 0 0
DNA Replication R-HSA-69306 1.731573e-07 6.762 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.794730e-07 6.746 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.909015e-07 6.719 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.413078e-07 6.617 0 0
Cell-cell junction organization R-HSA-421270 2.750617e-07 6.561 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.761829e-07 6.559 0 0
Packaging Of Telomere Ends R-HSA-171306 2.920417e-07 6.535 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.968701e-07 6.527 0 0
Viral Infection Pathways R-HSA-9824446 3.064077e-07 6.514 1 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.945506e-07 6.531 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.081198e-07 6.511 0 0
Meiotic recombination R-HSA-912446 3.561170e-07 6.448 0 0
Meiosis R-HSA-1500620 3.564247e-07 6.448 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.806698e-07 6.419 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.539304e-07 6.343 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.652665e-07 6.332 0 0
Defective pyroptosis R-HSA-9710421 4.787151e-07 6.320 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.499667e-07 6.260 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.583572e-07 6.253 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.698670e-07 6.244 0 0
Meiotic synapsis R-HSA-1221632 6.239918e-07 6.205 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.421478e-07 6.130 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.421478e-07 6.130 0 0
Selective autophagy R-HSA-9663891 8.327306e-07 6.079 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.345660e-07 6.079 0 0
Nucleosome assembly R-HSA-774815 8.745772e-07 6.058 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.745772e-07 6.058 0 0
Cellular response to starvation R-HSA-9711097 8.993692e-07 6.046 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.700769e-07 6.060 0 0
Gene Silencing by RNA R-HSA-211000 9.237379e-07 6.034 0 0
Developmental Biology R-HSA-1266738 1.017541e-06 5.992 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.152296e-06 5.938 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.269237e-06 5.896 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.319708e-06 5.880 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.319708e-06 5.880 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.427528e-06 5.845 0 0
Chromatin modifying enzymes R-HSA-3247509 1.543055e-06 5.812 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.717085e-06 5.765 0 0
G2/M Transition R-HSA-69275 1.752105e-06 5.756 0 0
Regulation of CDH1 Function R-HSA-9764561 1.782081e-06 5.749 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.831770e-06 5.737 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.933003e-06 5.714 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.933003e-06 5.714 0 0
Interleukin-12 family signaling R-HSA-447115 1.975728e-06 5.704 0 0
RNA Polymerase I Transcription R-HSA-73864 2.191658e-06 5.659 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.265632e-06 5.645 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.925710e-06 5.534 0 0
PKR-mediated signaling R-HSA-9833482 3.316303e-06 5.479 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.316303e-06 5.479 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.333616e-06 5.477 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.606389e-06 5.443 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.847467e-06 5.415 0 0
Chromatin organization R-HSA-4839726 4.010696e-06 5.397 0 0
Amyloid fiber formation R-HSA-977225 4.058073e-06 5.392 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.236663e-06 5.373 0 0
Signaling by RAS mutants R-HSA-6802949 4.236663e-06 5.373 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.236663e-06 5.373 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.236663e-06 5.373 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.236663e-06 5.373 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.473622e-06 5.349 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.606230e-06 5.337 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.100331e-06 5.292 0 0
Depyrimidination R-HSA-73928 5.100331e-06 5.292 0 0
Chromosome Maintenance R-HSA-73886 5.266181e-06 5.279 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.551045e-06 5.256 1 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.777732e-06 5.238 0 0
ESR-mediated signaling R-HSA-8939211 8.942477e-06 5.049 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.338131e-06 5.030 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.495661e-06 5.022 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.977938e-06 5.001 0 0
Selenoamino acid metabolism R-HSA-2408522 1.054899e-05 4.977 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.215878e-05 4.915 0 0
Signaling by ERBB2 R-HSA-1227986 1.167693e-05 4.933 0 0
Kinesins R-HSA-983189 1.167693e-05 4.933 0 0
Cleavage of the damaged purine R-HSA-110331 1.271362e-05 4.896 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.379611e-05 4.860 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.391681e-05 4.856 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.522504e-05 4.817 0 0
Depurination R-HSA-73927 1.683446e-05 4.774 0 0
HCMV Infection R-HSA-9609646 1.724221e-05 4.763 0 0
Telomere Maintenance R-HSA-157579 1.739420e-05 4.760 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.816848e-05 4.741 0 0
Homology Directed Repair R-HSA-5693538 1.962506e-05 4.707 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.089583e-05 4.680 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.100285e-05 4.678 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.391982e-05 4.621 0 0
HATs acetylate histones R-HSA-3214847 2.409004e-05 4.618 0 0
Interferon Signaling R-HSA-913531 2.403266e-05 4.619 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.618490e-05 4.582 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.630379e-05 4.580 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.748598e-05 4.561 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.872061e-05 4.542 0 0
Gap junction trafficking R-HSA-190828 2.991146e-05 4.524 0 0
Gap junction trafficking and regulation R-HSA-157858 3.015052e-05 4.521 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.076662e-05 4.512 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.667962e-05 4.436 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.867983e-05 4.413 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.938193e-05 4.405 0 0
Signaling by ALK in cancer R-HSA-9700206 3.938193e-05 4.405 0 0
Autophagy R-HSA-9612973 3.965583e-05 4.402 0 0
Protein folding R-HSA-391251 4.217721e-05 4.375 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.536428e-05 4.343 0 0
Signaling by Hippo R-HSA-2028269 4.536545e-05 4.343 0 0
Signaling by EGFR R-HSA-177929 4.568597e-05 4.340 0 0
Signaling by NOTCH R-HSA-157118 4.571829e-05 4.340 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.587563e-05 4.338 0 0
Membrane Trafficking R-HSA-199991 4.593789e-05 4.338 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.600658e-05 4.337 0 0
DNA Double Strand Break Response R-HSA-5693606 4.926118e-05 4.307 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.221592e-05 4.282 1 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.299952e-05 4.276 0 0
Macroautophagy R-HSA-1632852 5.580112e-05 4.253 0 0
Striated Muscle Contraction R-HSA-390522 5.582978e-05 4.253 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.684452e-05 4.175 0 0
mRNA Splicing R-HSA-72172 6.732559e-05 4.172 0 0
Glycolysis R-HSA-70171 6.921812e-05 4.160 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.999361e-05 4.155 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.200156e-05 4.086 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.965612e-05 4.047 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.990756e-05 4.046 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.019573e-05 4.045 0 0
HIV Life Cycle R-HSA-162587 9.357331e-05 4.029 0 0
RMTs methylate histone arginines R-HSA-3214858 9.689885e-05 4.014 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.785859e-05 4.009 0 0
Host Interactions of HIV factors R-HSA-162909 1.026607e-04 3.989 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.215244e-04 3.915 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.223086e-04 3.913 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.265230e-04 3.898 1 0
Switching of origins to a post-replicative state R-HSA-69052 1.451640e-04 3.838 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.519204e-04 3.818 0 0
MAP2K and MAPK activation R-HSA-5674135 1.552184e-04 3.809 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.504280e-04 3.823 0 0
HIV Infection R-HSA-162906 1.682278e-04 3.774 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.623297e-04 3.790 0 0
MAPK family signaling cascades R-HSA-5683057 1.829346e-04 3.738 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.842636e-04 3.735 0 0
Protein ubiquitination R-HSA-8852135 2.024776e-04 3.694 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.176797e-04 3.662 0 0
Translation R-HSA-72766 2.267794e-04 3.644 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.433498e-04 3.614 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.434002e-04 3.614 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.490019e-04 3.604 0 0
RAF activation R-HSA-5673000 2.506611e-04 3.601 0 0
Gap junction assembly R-HSA-190861 2.506611e-04 3.601 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.578390e-04 3.589 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.686322e-04 3.571 0 0
Reproduction R-HSA-1474165 2.729398e-04 3.564 0 0
Signaling by VEGF R-HSA-194138 2.845189e-04 3.546 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.110832e-04 3.507 0 0
NF-kB is activated and signals survival R-HSA-209560 3.154018e-04 3.501 1 1
p75NTR signals via NF-kB R-HSA-193639 3.216686e-04 3.493 1 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.706277e-04 3.431 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.731615e-04 3.428 0 0
Hedgehog 'off' state R-HSA-5610787 3.752357e-04 3.426 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.838039e-04 3.416 0 0
Base Excision Repair R-HSA-73884 3.841285e-04 3.416 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.925495e-04 3.406 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.001242e-04 3.398 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.805033e-04 3.318 1 1
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.931179e-04 3.307 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.414814e-04 3.355 1 1
Negative regulation of MAPK pathway R-HSA-5675221 4.759728e-04 3.322 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.997841e-04 3.301 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.414814e-04 3.355 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.016115e-04 3.300 0 0
Signaling by PTK6 R-HSA-8848021 4.734863e-04 3.325 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.734863e-04 3.325 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.117479e-04 3.291 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.117479e-04 3.291 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.234356e-04 3.281 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.272274e-04 3.203 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.272274e-04 3.203 0 0
Neurodegenerative Diseases R-HSA-8863678 6.272274e-04 3.203 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.442256e-04 3.191 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.495602e-04 3.187 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.095687e-04 3.149 0 0
Platelet degranulation R-HSA-114608 7.396219e-04 3.131 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.627144e-04 3.118 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.627144e-04 3.118 0 0
Neutrophil degranulation R-HSA-6798695 7.822881e-04 3.107 0 0
Degradation of CDH1 R-HSA-9766229 7.824601e-04 3.107 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.879642e-04 3.103 0 0
Nuclear import of Rev protein R-HSA-180746 8.044992e-04 3.094 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.255436e-04 3.083 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.363016e-04 3.078 0 0
Muscle contraction R-HSA-397014 8.972413e-04 3.047 0 0
Glucose metabolism R-HSA-70326 9.181628e-04 3.037 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.341856e-04 3.030 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.341856e-04 3.030 0 0
Regulation of PTEN localization R-HSA-8948747 9.615444e-04 3.017 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.652550e-04 3.015 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.019330e-03 2.992 0 0
Signaling by ERBB4 R-HSA-1236394 1.046114e-03 2.980 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.067085e-03 2.972 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.067085e-03 2.972 0 0
S Phase R-HSA-69242 1.129636e-03 2.947 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.226559e-03 2.911 0 0
RET signaling R-HSA-8853659 1.226559e-03 2.911 0 0
mTORC1-mediated signalling R-HSA-166208 1.318513e-03 2.880 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.498547e-03 2.824 0 0
Orc1 removal from chromatin R-HSA-68949 1.317356e-03 2.880 0 0
EPH-Ephrin signaling R-HSA-2682334 1.285825e-03 2.891 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.335299e-03 2.874 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.428767e-03 2.845 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.383200e-03 2.859 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.415503e-03 2.849 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.428767e-03 2.845 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.553896e-03 2.809 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.575143e-03 2.803 0 0
Signaling by Interleukins R-HSA-449147 1.611215e-03 2.793 1 0
Rap1 signalling R-HSA-392517 1.628670e-03 2.788 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.650288e-03 2.782 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.702025e-03 2.769 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.818749e-03 2.740 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.862187e-03 2.730 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.899877e-03 2.721 0 0
Synthesis of DNA R-HSA-69239 2.089090e-03 2.680 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.119664e-03 2.674 0 0
Negative regulation of MET activity R-HSA-6807004 2.137106e-03 2.670 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.166691e-03 2.664 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.193433e-03 2.659 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.193433e-03 2.659 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.254129e-03 2.647 1 1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.254129e-03 2.647 1 1
Late Phase of HIV Life Cycle R-HSA-162599 2.288360e-03 2.640 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.389706e-03 2.622 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.505638e-03 2.601 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.597155e-03 2.586 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.605249e-03 2.584 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.764522e-03 2.558 0 0
DAG and IP3 signaling R-HSA-1489509 2.773764e-03 2.557 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.866210e-03 2.543 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.866210e-03 2.543 0 0
Semaphorin interactions R-HSA-373755 2.866210e-03 2.543 0 0
UCH proteinases R-HSA-5689603 3.120278e-03 2.506 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.185901e-03 2.497 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.185901e-03 2.497 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.264880e-03 2.486 0 0
Ub-specific processing proteases R-HSA-5689880 3.288447e-03 2.483 0 0
mRNA 3'-end processing R-HSA-72187 3.325444e-03 2.478 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.407032e-03 2.468 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.507496e-03 2.455 0 0
Calmodulin induced events R-HSA-111933 3.507760e-03 2.455 0 0
CaM pathway R-HSA-111997 3.507760e-03 2.455 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.525370e-03 2.453 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.529299e-03 2.452 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.714014e-03 2.430 0 0
MTF1 activates gene expression R-HSA-5660489 4.677282e-03 2.330 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.267806e-03 2.370 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.514714e-03 2.345 0 0
Ephrin signaling R-HSA-3928664 4.514714e-03 2.345 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.209623e-03 2.376 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.683348e-03 2.329 0 0
snRNP Assembly R-HSA-191859 3.834864e-03 2.416 0 0
Metabolism of non-coding RNA R-HSA-194441 3.834864e-03 2.416 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.461722e-03 2.350 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.683348e-03 2.329 0 0
DNA Repair R-HSA-73894 4.244335e-03 2.372 0 0
Gene expression (Transcription) R-HSA-74160 3.857879e-03 2.414 1 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.514714e-03 2.345 0 0
Smooth Muscle Contraction R-HSA-445355 3.859531e-03 2.413 0 0
HCMV Late Events R-HSA-9610379 4.573303e-03 2.340 0 0
Infectious disease R-HSA-5663205 3.960345e-03 2.402 1 0
COPI-mediated anterograde transport R-HSA-6807878 4.746548e-03 2.324 0 0
Signaling by Hedgehog R-HSA-5358351 4.959586e-03 2.305 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.980441e-03 2.303 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.995010e-03 2.301 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.022068e-03 2.299 1 1
MAPK1/MAPK3 signaling R-HSA-5684996 5.322297e-03 2.274 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.441551e-03 2.264 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.616897e-03 2.251 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.679050e-03 2.246 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.679050e-03 2.246 0 0
Hemostasis R-HSA-109582 5.729892e-03 2.242 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.739134e-03 2.241 0 0
tRNA processing in the nucleus R-HSA-6784531 5.739134e-03 2.241 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.776211e-03 2.238 0 0
Signaling by WNT R-HSA-195721 5.968847e-03 2.224 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.988336e-03 2.223 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.003027e-03 2.222 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.003027e-03 2.222 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.312858e-03 2.200 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.909151e-03 2.161 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.933672e-03 2.159 0 0
Integration of provirus R-HSA-162592 6.933672e-03 2.159 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.132164e-03 2.147 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.289400e-03 2.137 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.909358e-03 2.102 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.919786e-03 2.101 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.954401e-03 2.099 0 0
Formation of annular gap junctions R-HSA-196025 7.977704e-03 2.098 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.977704e-03 2.098 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.977704e-03 2.098 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.052509e-03 2.094 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.082438e-03 2.092 0 0
Co-inhibition by PD-1 R-HSA-389948 8.229658e-03 2.085 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.365972e-03 2.077 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.365972e-03 2.077 0 0
Long-term potentiation R-HSA-9620244 8.365972e-03 2.077 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.666837e-03 2.062 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.007263e-03 2.045 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.037650e-03 2.044 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.037650e-03 2.044 0 0
SARS-CoV Infections R-HSA-9679506 9.052846e-03 2.043 1 0
Early Phase of HIV Life Cycle R-HSA-162594 9.083461e-03 2.042 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.271680e-03 2.033 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.271680e-03 2.033 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.326587e-03 2.030 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 9.326587e-03 2.030 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 9.326587e-03 2.030 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.382151e-03 2.028 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.382151e-03 2.028 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.510383e-03 2.022 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.510383e-03 2.022 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.510383e-03 2.022 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.510383e-03 2.022 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.958360e-03 2.002 0 0
Metalloprotease DUBs R-HSA-5689901 1.012709e-02 1.995 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.022764e-02 1.990 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.022764e-02 1.990 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.022764e-02 1.990 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.022764e-02 1.990 0 0
Immune System R-HSA-168256 1.034171e-02 1.985 1 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.036803e-02 1.984 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.068869e-02 1.971 0 0
Ca-dependent events R-HSA-111996 1.085203e-02 1.964 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.246117e-02 1.904 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.246117e-02 1.904 0 0
Gap junction degradation R-HSA-190873 1.128321e-02 1.948 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.225708e-02 1.912 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.118776e-02 1.951 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.363146e-02 1.865 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.259817e-02 1.900 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.167226e-02 1.933 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.319604e-02 1.880 0 0
Centrosome maturation R-HSA-380287 1.236668e-02 1.908 0 0
G1/S Transition R-HSA-69206 1.448647e-02 1.839 0 0
Degradation of DVL R-HSA-4641258 1.089669e-02 1.963 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.363146e-02 1.865 0 0
Ion homeostasis R-HSA-5578775 1.319604e-02 1.880 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.113377e-02 1.953 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.215349e-02 1.915 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.431862e-02 1.844 0 0
MHC class II antigen presentation R-HSA-2132295 1.140693e-02 1.943 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.319604e-02 1.880 0 0
Maturation of protein E R-HSA-9694493 1.246117e-02 1.904 0 0
Maturation of protein E R-HSA-9683683 1.246117e-02 1.904 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.162303e-02 1.935 1 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.466260e-02 1.834 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.475349e-02 1.831 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.475349e-02 1.831 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.541635e-02 1.812 0 0
2-LTR circle formation R-HSA-164843 1.541635e-02 1.812 0 0
Josephin domain DUBs R-HSA-5689877 1.541635e-02 1.812 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.541635e-02 1.812 0 0
Pexophagy R-HSA-9664873 1.541635e-02 1.812 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.578062e-02 1.802 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.578062e-02 1.802 0 0
Deubiquitination R-HSA-5688426 1.588867e-02 1.799 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.633962e-02 1.787 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.634222e-02 1.787 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.634222e-02 1.787 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.644316e-02 1.784 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.681226e-02 1.774 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.687773e-02 1.773 0 0
Late endosomal microautophagy R-HSA-9615710 1.709126e-02 1.767 0 0
Dual Incision in GG-NER R-HSA-5696400 1.717231e-02 1.765 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.717231e-02 1.765 0 0
Mitophagy R-HSA-5205647 1.717231e-02 1.765 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.721538e-02 1.764 0 0
RNA Polymerase II Transcription R-HSA-73857 1.725852e-02 1.763 1 0
Cilium Assembly R-HSA-5617833 1.791751e-02 1.747 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.811372e-02 1.742 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.837793e-02 1.736 0 0
FLT3 Signaling R-HSA-9607240 1.933349e-02 1.714 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.933349e-02 1.714 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.944962e-02 1.711 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.965051e-02 1.707 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.987197e-02 1.702 0 0
Regulation of Apoptosis R-HSA-169911 1.987197e-02 1.702 0 0
Signalling to ERKs R-HSA-187687 1.987197e-02 1.702 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.994865e-02 1.700 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.994865e-02 1.700 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.994865e-02 1.700 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.994865e-02 1.700 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.994865e-02 1.700 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.994865e-02 1.700 0 0
Activation of the pre-replicative complex R-HSA-68962 2.004619e-02 1.698 0 0
Activation of BH3-only proteins R-HSA-114452 2.004619e-02 1.698 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.087476e-02 1.680 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.091128e-02 1.680 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.091128e-02 1.680 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.091128e-02 1.680 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.091128e-02 1.680 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.091128e-02 1.680 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.091128e-02 1.680 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.091128e-02 1.680 0 0
Cellular response to chemical stress R-HSA-9711123 2.093050e-02 1.679 0 0
Vesicle-mediated transport R-HSA-5653656 2.118100e-02 1.674 0 0
Transmission across Chemical Synapses R-HSA-112315 2.140390e-02 1.670 0 0
Signaling by NOTCH4 R-HSA-9013694 2.209446e-02 1.656 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.231681e-02 1.651 0 0
Signal transduction by L1 R-HSA-445144 2.231681e-02 1.651 0 0
HDMs demethylate histones R-HSA-3214842 2.327986e-02 1.633 0 0
EGFR downregulation R-HSA-182971 2.335306e-02 1.632 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.389225e-02 1.622 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.478450e-02 1.606 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.478450e-02 1.606 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.478450e-02 1.606 0 0
Negative regulation of FLT3 R-HSA-9706369 2.480753e-02 1.605 0 0
Signaling by NOTCH3 R-HSA-9012852 2.492047e-02 1.603 0 0
MTOR signalling R-HSA-165159 2.502289e-02 1.602 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.568313e-02 1.590 0 0
SOS-mediated signalling R-HSA-112412 2.568313e-02 1.590 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.645984e-02 1.577 0 0
DNA Damage Bypass R-HSA-73893 2.662130e-02 1.575 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.680361e-02 1.572 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.703162e-02 1.568 0 0
PTEN Regulation R-HSA-6807070 2.712124e-02 1.567 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.735593e-02 1.563 0 0
Signaling by FGFR4 R-HSA-5654743 2.828347e-02 1.548 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.854350e-02 1.544 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.902287e-02 1.537 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.902287e-02 1.537 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.919295e-02 1.535 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.941462e-02 1.531 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.039777e-02 1.517 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.110041e-02 1.507 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.110041e-02 1.507 0 0
Ion transport by P-type ATPases R-HSA-936837 3.150903e-02 1.502 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.186759e-02 1.497 0 0
TCR signaling R-HSA-202403 3.270266e-02 1.485 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.348598e-02 1.475 0 0
Disorders of Nervous System Development R-HSA-9697154 3.348598e-02 1.475 0 0
Pervasive developmental disorders R-HSA-9005895 3.348598e-02 1.475 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.348598e-02 1.475 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 3.348598e-02 1.475 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 3.348598e-02 1.475 0 0
Stabilization of p53 R-HSA-69541 3.380679e-02 1.471 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.389526e-02 1.470 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.456924e-02 1.461 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.456924e-02 1.461 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.456924e-02 1.461 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.456924e-02 1.461 0 0
Sensory processing of sound R-HSA-9659379 3.491321e-02 1.457 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.557658e-02 1.449 0 0
Signaling by FGFR3 R-HSA-5654741 3.569953e-02 1.447 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.675337e-02 1.435 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.675337e-02 1.435 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.675337e-02 1.435 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 4.380204e-02 1.359 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.380204e-02 1.359 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.315025e-02 1.365 0 0
Deadenylation of mRNA R-HSA-429947 5.075852e-02 1.294 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.047572e-02 1.393 0 0
GPER1 signaling R-HSA-9634597 4.922793e-02 1.308 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.475267e-02 1.262 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.533436e-02 1.344 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.817890e-02 1.418 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.502809e-02 1.347 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.073412e-02 1.295 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.413169e-02 1.267 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.502809e-02 1.347 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.315025e-02 1.365 0 0
Budding and maturation of HIV virion R-HSA-162588 5.515261e-02 1.258 0 0
Trafficking of AMPA receptors R-HSA-399719 5.515261e-02 1.258 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.286260e-02 1.368 0 0
G alpha (z) signalling events R-HSA-418597 4.984909e-02 1.302 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.380204e-02 1.359 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.581166e-02 1.339 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.286260e-02 1.368 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.286260e-02 1.368 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.801984e-02 1.420 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.186144e-02 1.285 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.693720e-02 1.433 0 0
Oncogene Induced Senescence R-HSA-2559585 4.581166e-02 1.339 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.286260e-02 1.368 0 0
Generic Transcription Pathway R-HSA-212436 3.765894e-02 1.424 1 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.502809e-02 1.347 0 0
Unwinding of DNA R-HSA-176974 4.502809e-02 1.347 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.814961e-02 1.419 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.159639e-02 1.287 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.441677e-02 1.264 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.441677e-02 1.264 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.946126e-02 1.306 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.729593e-02 1.325 0 0
Adaptive Immune System R-HSA-1280218 4.377111e-02 1.359 0 0
Signaling by FGFR1 R-HSA-5654736 5.475267e-02 1.262 0 0
FLT3 signaling in disease R-HSA-9682385 5.159639e-02 1.287 0 0
Regulation of TP53 Activity R-HSA-5633007 4.160276e-02 1.381 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.047572e-02 1.393 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.047572e-02 1.393 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.475267e-02 1.262 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.073412e-02 1.295 0 0
Disease R-HSA-1643685 3.861357e-02 1.413 1 0
Gluconeogenesis R-HSA-70263 4.922793e-02 1.308 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.390135e-02 1.358 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.599182e-02 1.252 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.706143e-02 1.244 0 0
G alpha (12/13) signalling events R-HSA-416482 5.776197e-02 1.238 0 0
PCP/CE pathway R-HSA-4086400 5.776197e-02 1.238 0 0
Degradation of AXIN R-HSA-4641257 5.783992e-02 1.238 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.783992e-02 1.238 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.834619e-02 1.234 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.834619e-02 1.234 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.932721e-02 1.227 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.953316e-02 1.225 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.953316e-02 1.225 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.953316e-02 1.225 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.997094e-02 1.222 0 0
Protein hydroxylation R-HSA-9629569 6.064597e-02 1.217 0 0
Nephrin family interactions R-HSA-373753 6.064597e-02 1.217 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.098916e-02 1.215 0 0
p38MAPK events R-HSA-171007 6.098916e-02 1.215 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.098916e-02 1.215 0 0
Protein methylation R-HSA-8876725 6.098916e-02 1.215 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.359796e-02 1.197 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.455015e-02 1.190 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.455015e-02 1.190 0 0
Cellular response to hypoxia R-HSA-1234174 6.473864e-02 1.189 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.551020e-02 1.184 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.561836e-02 1.183 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.561836e-02 1.183 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.585834e-02 1.181 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.585834e-02 1.181 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.611946e-02 1.180 1 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.659697e-02 1.177 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.659697e-02 1.177 0 0
Signaling by MET R-HSA-6806834 6.723318e-02 1.172 0 0
Signaling by FGFR2 R-HSA-5654738 6.723318e-02 1.172 0 0
Developmental Cell Lineages R-HSA-9734767 6.910579e-02 1.160 0 0
Integrin signaling R-HSA-354192 7.000525e-02 1.155 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.000525e-02 1.155 0 0
PECAM1 interactions R-HSA-210990 7.064253e-02 1.151 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.064253e-02 1.151 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.173285e-02 1.144 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.212196e-02 1.142 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.232099e-02 1.141 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.232099e-02 1.141 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.232099e-02 1.141 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.232099e-02 1.141 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.233102e-02 1.141 0 0
Prolonged ERK activation events R-HSA-169893 7.233102e-02 1.141 0 0
Signaling by RAS GAP mutants R-HSA-9753510 7.254461e-02 1.139 0 0
Interleukin-1 signaling R-HSA-9020702 7.524848e-02 1.124 1 1
EPHA-mediated growth cone collapse R-HSA-3928663 7.551465e-02 1.122 0 0
G-protein mediated events R-HSA-112040 7.603021e-02 1.119 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.826421e-02 1.106 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.838623e-02 1.106 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.838623e-02 1.106 0 0
CREB phosphorylation R-HSA-199920 7.838623e-02 1.106 0 0
Glycogen metabolism R-HSA-8982491 7.939160e-02 1.100 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.943870e-02 1.100 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.943870e-02 1.100 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.070073e-02 1.093 1 1
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.070073e-02 1.093 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.070073e-02 1.093 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 8.070073e-02 1.093 0 0
MAP kinase activation R-HSA-450294 8.408637e-02 1.075 1 0
Viral Messenger RNA Synthesis R-HSA-168325 8.408637e-02 1.075 0 0
PLC beta mediated events R-HSA-112043 8.408637e-02 1.075 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 8.474351e-02 1.072 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.474351e-02 1.072 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.474351e-02 1.072 0 0
Disorders of Developmental Biology R-HSA-9675151 8.474351e-02 1.072 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.474351e-02 1.072 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.474351e-02 1.072 1 1
Negative regulation of FGFR3 signaling R-HSA-5654732 8.509850e-02 1.070 0 0
Activation of RAC1 R-HSA-428540 8.571977e-02 1.067 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.571977e-02 1.067 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.571977e-02 1.067 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.695889e-02 1.061 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.697342e-02 1.061 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.752773e-02 1.058 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.752773e-02 1.058 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.914864e-02 1.050 0 0
Opioid Signalling R-HSA-111885 9.045183e-02 1.044 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.195920e-02 1.036 0 0
Signaling by TGFB family members R-HSA-9006936 9.309313e-02 1.031 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.492539e-02 1.023 0 0
Intraflagellar transport R-HSA-5620924 9.492539e-02 1.023 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.521249e-02 1.021 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.534330e-02 1.021 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.534330e-02 1.021 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.614036e-02 1.017 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.644985e-02 1.016 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 9.644985e-02 1.016 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.812890e-02 1.008 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.819887e-02 1.008 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.948614e-02 1.002 0 0
Disinhibition of SNARE formation R-HSA-114516 9.948614e-02 1.002 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.948614e-02 1.002 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.948614e-02 1.002 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.989141e-02 1.000 1 1
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.989141e-02 1.000 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.989141e-02 1.000 1 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.008642e-01 0.996 0 0
TNF signaling R-HSA-75893 1.008642e-01 0.996 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.016107e-01 0.993 1 0
Death Receptor Signaling R-HSA-73887 1.019108e-01 0.992 1 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.022103e-01 0.991 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.041506e-01 0.982 0 0
KIT mutants bind TKIs R-HSA-9669921 1.041506e-01 0.982 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.041506e-01 0.982 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.041506e-01 0.982 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.041506e-01 0.982 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.041506e-01 0.982 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.041506e-01 0.982 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.041506e-01 0.982 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.041506e-01 0.982 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.056731e-01 0.976 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.056731e-01 0.976 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.056731e-01 0.976 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.062395e-01 0.974 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.974593e-01 0.705 0 0
Hereditary fructose intolerance R-HSA-5657560 1.974593e-01 0.705 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.974593e-01 0.705 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.974593e-01 0.705 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.974593e-01 0.705 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.974593e-01 0.705 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.974593e-01 0.705 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.974593e-01 0.705 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.419632e-01 0.848 0 0
Regulation of gap junction activity R-HSA-191650 1.419632e-01 0.848 0 0
NADE modulates death signalling R-HSA-205025 1.419632e-01 0.848 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.419632e-01 0.848 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.419632e-01 0.848 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.803979e-01 0.744 0 0
IRS activation R-HSA-74713 1.803979e-01 0.744 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.803979e-01 0.744 0 0
Type I hemidesmosome assembly R-HSA-446107 1.225805e-01 0.912 0 0
RSK activation R-HSA-444257 1.225805e-01 0.912 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.225805e-01 0.912 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.225805e-01 0.912 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.225805e-01 0.912 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.474016e-01 0.831 0 0
ARMS-mediated activation R-HSA-170984 1.474016e-01 0.831 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.201374e-01 0.657 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.201374e-01 0.657 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.201374e-01 0.657 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.736764e-01 0.760 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.736764e-01 0.760 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.391179e-01 0.857 0 0
GAB1 signalosome R-HSA-180292 1.126589e-01 0.948 0 0
PKA activation in glucagon signalling R-HSA-164378 1.126589e-01 0.948 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.011350e-01 0.697 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.280762e-01 0.893 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.443954e-01 0.840 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.443954e-01 0.840 0 0
Translesion synthesis by POLI R-HSA-5656121 1.804691e-01 0.744 0 0
Phosphorylation of the APC/C R-HSA-176412 1.804691e-01 0.744 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.804691e-01 0.744 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.025094e-01 0.694 0 0
Translesion synthesis by POLK R-HSA-5655862 2.025094e-01 0.694 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 1.447574e-01 0.839 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.794854e-01 0.746 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.597458e-01 0.797 0 0
HIV elongation arrest and recovery R-HSA-167287 1.753723e-01 0.756 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.753723e-01 0.756 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.915914e-01 0.718 0 0
Dual incision in TC-NER R-HSA-6782135 1.174485e-01 0.930 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.594944e-01 0.797 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.844067e-01 0.734 1 1
Signaling by NOTCH2 R-HSA-1980145 1.698804e-01 0.770 0 0
Nucleotide Excision Repair R-HSA-5696398 1.543393e-01 0.812 0 0
DAP12 signaling R-HSA-2424491 2.083551e-01 0.681 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.408361e-01 0.851 0 0
Signaling by SCF-KIT R-HSA-1433557 2.038802e-01 0.691 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.513148e-01 0.820 0 0
Translesion Synthesis by POLH R-HSA-110320 1.280762e-01 0.893 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.637932e-01 0.786 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.352613e-01 0.869 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.803979e-01 0.744 0 0
Translesion synthesis by REV1 R-HSA-110312 1.592967e-01 0.798 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.804691e-01 0.744 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.308523e-01 0.883 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.831102e-01 0.737 1 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.200544e-01 0.921 0 0
PKA activation R-HSA-163615 1.126589e-01 0.948 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.352613e-01 0.869 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.813814e-01 0.741 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.585289e-01 0.800 1 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.615543e-01 0.792 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.354774e-01 0.868 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.354774e-01 0.868 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.354774e-01 0.868 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.354774e-01 0.868 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.144633e-01 0.669 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.331078e-01 0.876 1 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.083816e-01 0.681 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.331078e-01 0.876 1 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.915914e-01 0.718 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 2.083551e-01 0.681 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.974593e-01 0.705 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.736764e-01 0.760 0 0
DCC mediated attractive signaling R-HSA-418885 1.592967e-01 0.798 0 0
DNA strand elongation R-HSA-69190 1.299273e-01 0.886 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.212622e-01 0.916 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.301827e-01 0.885 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.195932e-01 0.658 1 1
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.195932e-01 0.658 1 0
ER-Phagosome pathway R-HSA-1236974 1.296264e-01 0.887 0 0
Frs2-mediated activation R-HSA-170968 1.200544e-01 0.921 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.177734e-01 0.929 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.474016e-01 0.831 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.391179e-01 0.857 0 0
Signalling to RAS R-HSA-167044 1.615543e-01 0.792 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.352613e-01 0.869 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.147805e-01 0.940 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.198942e-01 0.921 1 1
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.263992e-01 0.898 1 1
Signal attenuation R-HSA-74749 1.736764e-01 0.760 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.767293e-01 0.753 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.794854e-01 0.746 0 0
Interleukin-17 signaling R-HSA-448424 1.575888e-01 0.802 1 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.915914e-01 0.718 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.354774e-01 0.868 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.208071e-01 0.918 1 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.544363e-01 0.811 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.974593e-01 0.705 0 0
Inhibition of PKR R-HSA-169131 1.974593e-01 0.705 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.225805e-01 0.912 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.474016e-01 0.831 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.474016e-01 0.831 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.201374e-01 0.657 0 0
Bicarbonate transporters R-HSA-425381 2.011350e-01 0.697 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.794854e-01 0.746 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.698804e-01 0.770 0 0
Signaling by FGFR R-HSA-190236 1.539611e-01 0.813 0 0
Netrin-1 signaling R-HSA-373752 1.247953e-01 0.904 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.391179e-01 0.857 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.426801e-01 0.846 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.161003e-01 0.935 0 0
Regulation of signaling by CBL R-HSA-912631 1.280762e-01 0.893 0 0
RAS processing R-HSA-9648002 1.393154e-01 0.856 0 0
Adrenoceptors R-HSA-390696 1.225805e-01 0.912 0 0
Cyclin D associated events in G1 R-HSA-69231 2.180437e-01 0.661 0 0
G1 Phase R-HSA-69236 2.180437e-01 0.661 0 0
Regulated Necrosis R-HSA-5218859 1.390062e-01 0.857 0 0
Signaling by NTRKs R-HSA-166520 1.115968e-01 0.952 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.562573e-01 0.806 0 0
Neuronal System R-HSA-112316 1.430147e-01 0.845 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.426801e-01 0.846 0 0
Ion channel transport R-HSA-983712 2.184363e-01 0.661 0 0
Interleukin-1 family signaling R-HSA-446652 1.333764e-01 0.875 1 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.168268e-01 0.932 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.981167e-01 0.703 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.615543e-01 0.792 1 1
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.560070e-01 0.807 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.393154e-01 0.856 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.200544e-01 0.921 0 0
Syndecan interactions R-HSA-3000170 2.173734e-01 0.663 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.222417e-01 0.913 1 1
Butyrophilin (BTN) family interactions R-HSA-8851680 1.474016e-01 0.831 0 0
Assembly Of The HIV Virion R-HSA-175474 1.794854e-01 0.746 0 0
Hedgehog 'on' state R-HSA-5632684 1.673338e-01 0.776 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.900999e-01 0.721 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.352613e-01 0.869 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.352613e-01 0.869 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.091307e-01 0.680 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.201374e-01 0.657 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.038802e-01 0.691 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.804691e-01 0.744 0 0
Glycogen synthesis R-HSA-3322077 1.443954e-01 0.840 0 0
Response to metal ions R-HSA-5660526 2.025094e-01 0.694 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.474016e-01 0.831 0 0
Regulation of BACH1 activity R-HSA-9708530 1.804691e-01 0.744 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.126589e-01 0.948 0 0
Interleukin-37 signaling R-HSA-9008059 2.083551e-01 0.681 0 0
Signaling by NOTCH1 R-HSA-1980143 2.202317e-01 0.657 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.252896e-01 0.647 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.252896e-01 0.647 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.252896e-01 0.647 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.252896e-01 0.647 0 0
Glycogen storage diseases R-HSA-3229121 2.252896e-01 0.647 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.256129e-01 0.647 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.256129e-01 0.647 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.295167e-01 0.639 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.295167e-01 0.639 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.295167e-01 0.639 0 0
Potential therapeutics for SARS R-HSA-9679191 2.337450e-01 0.631 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.371784e-01 0.625 0 0
G0 and Early G1 R-HSA-1538133 2.433125e-01 0.614 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.463028e-01 0.609 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.463028e-01 0.609 0 0
ABC-family proteins mediated transport R-HSA-382556 2.465074e-01 0.608 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.467945e-01 0.608 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.467945e-01 0.608 1 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.486819e-01 0.604 0 0
Platelet sensitization by LDL R-HSA-432142 2.486819e-01 0.604 0 0
Mismatch Repair R-HSA-5358508 2.486819e-01 0.604 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.486819e-01 0.604 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.535135e-01 0.596 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.574539e-01 0.589 0 0
Interleukin-7 signaling R-HSA-1266695 2.574539e-01 0.589 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.585739e-01 0.587 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.585739e-01 0.587 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.585739e-01 0.587 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.604935e-01 0.584 0 0
Signaling by LTK in cancer R-HSA-9842640 2.604935e-01 0.584 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.604935e-01 0.584 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.604935e-01 0.584 0 0
Nef and signal transduction R-HSA-164944 2.604935e-01 0.584 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.604935e-01 0.584 0 0
Nuclear RNA decay R-HSA-9930044 2.614008e-01 0.583 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.625497e-01 0.581 1 1
Generation of second messenger molecules R-HSA-202433 2.627443e-01 0.580 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 2.725605e-01 0.565 0 0
The NLRP3 inflammasome R-HSA-844456 2.725605e-01 0.565 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.730214e-01 0.564 1 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.752218e-01 0.560 0 0
Co-stimulation by CD28 R-HSA-389356 2.779577e-01 0.556 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.781218e-01 0.556 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.794812e-01 0.554 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.810542e-01 0.551 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.810542e-01 0.551 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.810542e-01 0.551 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.810542e-01 0.551 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.810542e-01 0.551 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.810542e-01 0.551 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.810542e-01 0.551 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.810542e-01 0.551 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.810542e-01 0.551 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.810542e-01 0.551 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.810542e-01 0.551 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.810542e-01 0.551 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.810542e-01 0.551 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.810542e-01 0.551 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.810542e-01 0.551 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.810542e-01 0.551 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.810542e-01 0.551 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.810542e-01 0.551 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.810542e-01 0.551 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.810542e-01 0.551 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.810542e-01 0.551 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.810542e-01 0.551 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.880751e-01 0.540 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.880751e-01 0.540 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.880751e-01 0.540 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.937818e-01 0.532 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.958878e-01 0.529 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.968033e-01 0.528 0 0
Formation of definitive endoderm R-HSA-9823730 2.968033e-01 0.528 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.968033e-01 0.528 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.985279e-01 0.525 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.985279e-01 0.525 1 1
Downstream TCR signaling R-HSA-202424 2.987367e-01 0.525 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 2.991048e-01 0.524 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.991048e-01 0.524 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.991048e-01 0.524 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.991048e-01 0.524 0 0
Insulin processing R-HSA-264876 2.991048e-01 0.524 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.991048e-01 0.524 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.991048e-01 0.524 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.009070e-01 0.522 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.009070e-01 0.522 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.009070e-01 0.522 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.009070e-01 0.522 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.009070e-01 0.522 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.009070e-01 0.522 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.009070e-01 0.522 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.009070e-01 0.522 0 0
CHL1 interactions R-HSA-447041 3.009070e-01 0.522 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.009070e-01 0.522 0 0
Activation of GABAB receptors R-HSA-991365 3.136804e-01 0.504 0 0
GABA B receptor activation R-HSA-977444 3.136804e-01 0.504 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.136804e-01 0.504 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.136804e-01 0.504 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.174591e-01 0.498 0 0
Regulation of KIT signaling R-HSA-1433559 3.178074e-01 0.498 0 0
Zinc transporters R-HSA-435354 3.178074e-01 0.498 0 0
HDL assembly R-HSA-8963896 3.178074e-01 0.498 0 0
Extension of Telomeres R-HSA-180786 3.198984e-01 0.495 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.203268e-01 0.494 0 0
ERK/MAPK targets R-HSA-198753 3.212928e-01 0.493 0 0
G-protein activation R-HSA-202040 3.212928e-01 0.493 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 3.212928e-01 0.493 0 0
Basigin interactions R-HSA-210991 3.212928e-01 0.493 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.212928e-01 0.493 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.212928e-01 0.493 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.212928e-01 0.493 0 0
IRE1alpha activates chaperones R-HSA-381070 3.228592e-01 0.491 0 0
Transcription of the HIV genome R-HSA-167172 3.285308e-01 0.483 0 0
G1/S-Specific Transcription R-HSA-69205 3.365646e-01 0.473 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.409285e-01 0.467 0 0
Activation of RAS in B cells R-HSA-1169092 3.409285e-01 0.467 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.409285e-01 0.467 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.416264e-01 0.466 0 0
Signaling by Erythropoietin R-HSA-9006335 3.417143e-01 0.466 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.417143e-01 0.466 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.417143e-01 0.466 0 0
Platelet calcium homeostasis R-HSA-418360 3.417143e-01 0.466 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.417143e-01 0.466 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.420241e-01 0.466 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.459175e-01 0.461 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.459175e-01 0.461 0 0
Erythropoietin activates RAS R-HSA-9027284 3.475769e-01 0.459 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.475769e-01 0.459 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 3.475769e-01 0.459 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.475769e-01 0.459 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.475769e-01 0.459 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.475769e-01 0.459 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.475769e-01 0.459 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.475769e-01 0.459 0 0
Amine ligand-binding receptors R-HSA-375280 3.485801e-01 0.458 0 0
Aquaporin-mediated transport R-HSA-445717 3.501097e-01 0.456 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.501097e-01 0.456 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.549608e-01 0.450 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.559460e-01 0.449 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.559460e-01 0.449 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.559460e-01 0.449 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.559460e-01 0.449 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.559460e-01 0.449 0 0
Potassium transport channels R-HSA-1296067 3.559460e-01 0.449 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.559460e-01 0.449 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.559460e-01 0.449 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.559460e-01 0.449 0 0
C6 deamination of adenosine R-HSA-75102 3.559460e-01 0.449 0 0
Signalling to ERK5 R-HSA-198765 3.559460e-01 0.449 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.559460e-01 0.449 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.578963e-01 0.446 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.589848e-01 0.445 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.631958e-01 0.440 0 0
Somitogenesis R-HSA-9824272 3.661941e-01 0.436 0 0
Circadian clock R-HSA-9909396 3.664052e-01 0.436 0 0
Pyruvate metabolism R-HSA-70268 3.679741e-01 0.434 0 0
Signaling by KIT in disease R-HSA-9669938 3.705722e-01 0.431 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.705722e-01 0.431 0 0
FGFR2 alternative splicing R-HSA-6803529 3.705722e-01 0.431 0 0
Notch-HLH transcription pathway R-HSA-350054 3.705722e-01 0.431 0 0
Rab regulation of trafficking R-HSA-9007101 3.711931e-01 0.430 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.723040e-01 0.429 0 0
Toll-like Receptor Cascades R-HSA-168898 3.725597e-01 0.429 1 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.750923e-01 0.426 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.772096e-01 0.423 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.772096e-01 0.423 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.772096e-01 0.423 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.779546e-01 0.423 0 0
Lipophagy R-HSA-9613354 3.802014e-01 0.420 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.802014e-01 0.420 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.802014e-01 0.420 0 0
WNT mediated activation of DVL R-HSA-201688 3.802014e-01 0.420 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 3.802014e-01 0.420 0 0
ALK mutants bind TKIs R-HSA-9700645 3.802014e-01 0.420 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.802014e-01 0.420 0 0
Calcineurin activates NFAT R-HSA-2025928 3.802014e-01 0.420 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.802014e-01 0.420 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.802014e-01 0.420 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.802014e-01 0.420 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.802014e-01 0.420 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.802014e-01 0.420 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.802014e-01 0.420 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.814022e-01 0.419 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.838665e-01 0.416 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.838665e-01 0.416 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.859785e-01 0.413 0 0
Inositol phosphate metabolism R-HSA-1483249 3.910501e-01 0.408 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.916467e-01 0.407 0 0
Growth hormone receptor signaling R-HSA-982772 3.951590e-01 0.403 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.061723e-01 0.391 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.061723e-01 0.391 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.065508e-01 0.391 0 0
NRAGE signals death through JNK R-HSA-193648 4.070619e-01 0.390 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.137152e-01 0.383 0 0
Binding and entry of HIV virion R-HSA-173107 4.184475e-01 0.378 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.184475e-01 0.378 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.184475e-01 0.378 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.184475e-01 0.378 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.184475e-01 0.378 0 0
Regulation of CDH11 function R-HSA-9762292 4.184475e-01 0.378 0 0
PI3K/AKT activation R-HSA-198203 4.184475e-01 0.378 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.184475e-01 0.378 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.184475e-01 0.378 0 0
Formation of apoptosome R-HSA-111458 4.184475e-01 0.378 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.184475e-01 0.378 0 0
Signaling by Leptin R-HSA-2586552 4.184475e-01 0.378 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.195876e-01 0.377 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.195876e-01 0.377 0 0
Protein localization R-HSA-9609507 4.216706e-01 0.375 0 0
Regulation of insulin secretion R-HSA-422356 4.226304e-01 0.374 0 0
PLC-gamma1 signalling R-HSA-167021 4.230403e-01 0.374 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.230403e-01 0.374 0 0
Axonal growth stimulation R-HSA-209563 4.230403e-01 0.374 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.230403e-01 0.374 0 0
MET activates PTPN11 R-HSA-8865999 4.230403e-01 0.374 0 0
Invadopodia formation R-HSA-8941237 4.230403e-01 0.374 0 0
Classical Kir channels R-HSA-1296053 4.230403e-01 0.374 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.230403e-01 0.374 0 0
MET interacts with TNS proteins R-HSA-8875513 4.230403e-01 0.374 0 0
Type II Na+/Pi cotransporters R-HSA-427589 4.230403e-01 0.374 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.230403e-01 0.374 0 0
Histamine receptors R-HSA-390650 4.230403e-01 0.374 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.275416e-01 0.369 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.275416e-01 0.369 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.275416e-01 0.369 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.329467e-01 0.364 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.354651e-01 0.361 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.437752e-01 0.353 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.437752e-01 0.353 0 0
G protein gated Potassium channels R-HSA-1296059 4.437752e-01 0.353 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.437752e-01 0.353 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 4.468106e-01 0.350 0 0
Interferon alpha/beta signaling R-HSA-909733 4.494921e-01 0.347 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.520678e-01 0.345 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.554548e-01 0.342 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.554548e-01 0.342 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.554548e-01 0.342 0 0
Signaling by APC mutants R-HSA-4839744 4.554548e-01 0.342 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.554548e-01 0.342 0 0
Transport of RCbl within the body R-HSA-9758890 4.554548e-01 0.342 0 0
Suppression of apoptosis R-HSA-9635465 4.554548e-01 0.342 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.554548e-01 0.342 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.593005e-01 0.338 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.604458e-01 0.337 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.638353e-01 0.334 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 4.638353e-01 0.334 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.638353e-01 0.334 0 0
Polo-like kinase mediated events R-HSA-156711 4.638353e-01 0.334 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.638353e-01 0.334 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.638353e-01 0.334 0 0
Apoptotic factor-mediated response R-HSA-111471 4.638353e-01 0.334 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.676468e-01 0.330 0 0
Myogenesis R-HSA-525793 4.676468e-01 0.330 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.676468e-01 0.330 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.676468e-01 0.330 0 0
Signal amplification R-HSA-392518 4.697572e-01 0.328 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.697572e-01 0.328 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.697572e-01 0.328 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.697572e-01 0.328 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.723814e-01 0.326 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.727034e-01 0.325 0 0
ABC transporter disorders R-HSA-5619084 4.728987e-01 0.325 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.729974e-01 0.325 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.730244e-01 0.325 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.779599e-01 0.321 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.831487e-01 0.316 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.831487e-01 0.316 0 0
HCN channels R-HSA-1296061 4.831487e-01 0.316 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.831487e-01 0.316 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.831487e-01 0.316 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.831487e-01 0.316 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.831487e-01 0.316 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.831487e-01 0.316 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.831487e-01 0.316 0 0
Alanine metabolism R-HSA-8964540 4.831487e-01 0.316 0 0
Dopamine receptors R-HSA-390651 4.831487e-01 0.316 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.831487e-01 0.316 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.831487e-01 0.316 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.831487e-01 0.316 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.831487e-01 0.316 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.831487e-01 0.316 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 4.831487e-01 0.316 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.884815e-01 0.311 0 0
TBC/RABGAPs R-HSA-8854214 4.898218e-01 0.310 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.910663e-01 0.309 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.910663e-01 0.309 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.910663e-01 0.309 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.910663e-01 0.309 0 0
Signaling by AXIN mutants R-HSA-4839735 4.910663e-01 0.309 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.910663e-01 0.309 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.910663e-01 0.309 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.911353e-01 0.309 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.911353e-01 0.309 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.911353e-01 0.309 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.915615e-01 0.308 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.915615e-01 0.308 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.915615e-01 0.308 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.915615e-01 0.308 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.915615e-01 0.308 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.960161e-01 0.305 0 0
Mitochondrial protein import R-HSA-1268020 5.044527e-01 0.297 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.062633e-01 0.296 0 0
Proteasome assembly R-HSA-9907900 5.083826e-01 0.294 0 0
DAP12 interactions R-HSA-2172127 5.083826e-01 0.294 0 0
Telomere Extension By Telomerase R-HSA-171319 5.141811e-01 0.289 0 0
Inflammasomes R-HSA-622312 5.141811e-01 0.289 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.185602e-01 0.285 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.185602e-01 0.285 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.185602e-01 0.285 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.185602e-01 0.285 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.185602e-01 0.285 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.251712e-01 0.280 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.251712e-01 0.280 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.251712e-01 0.280 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.251712e-01 0.280 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.251712e-01 0.280 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.251712e-01 0.280 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.251712e-01 0.280 0 0
Repression of WNT target genes R-HSA-4641265 5.251712e-01 0.280 0 0
MET activates RAS signaling R-HSA-8851805 5.251712e-01 0.280 0 0
Leading Strand Synthesis R-HSA-69109 5.251712e-01 0.280 0 0
Polymerase switching R-HSA-69091 5.251712e-01 0.280 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.251712e-01 0.280 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.251712e-01 0.280 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.251712e-01 0.280 0 0
Leishmania infection R-HSA-9658195 5.310538e-01 0.275 0 0
Parasitic Infection Pathways R-HSA-9824443 5.310538e-01 0.275 0 0
Ca2+ pathway R-HSA-4086398 5.325155e-01 0.274 0 0
Platelet homeostasis R-HSA-418346 5.348246e-01 0.272 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.367319e-01 0.270 0 0
DARPP-32 events R-HSA-180024 5.367319e-01 0.270 0 0
G2 Phase R-HSA-68911 5.369980e-01 0.270 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 5.369980e-01 0.270 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.369980e-01 0.270 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.369980e-01 0.270 0 0
PTK6 Down-Regulation R-HSA-8849472 5.369980e-01 0.270 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.369980e-01 0.270 0 0
Reelin signalling pathway R-HSA-8866376 5.369980e-01 0.270 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.369980e-01 0.270 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.369980e-01 0.270 0 0
Inositol transporters R-HSA-429593 5.369980e-01 0.270 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.369980e-01 0.270 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.369980e-01 0.270 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.369980e-01 0.270 0 0
Diseases of DNA repair R-HSA-9675135 5.447118e-01 0.264 0 0
Lagging Strand Synthesis R-HSA-69186 5.447627e-01 0.264 0 0
Signaling by FGFR in disease R-HSA-1226099 5.471005e-01 0.262 0 0
Cardiac conduction R-HSA-5576891 5.502580e-01 0.259 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.576971e-01 0.254 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.576971e-01 0.254 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.576971e-01 0.254 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.576971e-01 0.254 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.587427e-01 0.253 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.587427e-01 0.253 0 0
SLC transporter disorders R-HSA-5619102 5.608831e-01 0.251 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.624240e-01 0.250 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.700701e-01 0.244 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.700701e-01 0.244 0 0
Signaling by ALK R-HSA-201556 5.700701e-01 0.244 0 0
Downstream signal transduction R-HSA-186763 5.801751e-01 0.236 0 0
Plus-strand DNA synthesis R-HSA-164525 5.852398e-01 0.233 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.852398e-01 0.233 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.852398e-01 0.233 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.852398e-01 0.233 0 0
Phosphorylation of Emi1 R-HSA-176417 5.852398e-01 0.233 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.852398e-01 0.233 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.852398e-01 0.233 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.852398e-01 0.233 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.852398e-01 0.233 0 0
Ceramide signalling R-HSA-193681 5.852398e-01 0.233 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.852398e-01 0.233 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.852398e-01 0.233 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.852398e-01 0.233 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.852398e-01 0.233 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.852398e-01 0.233 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.852398e-01 0.233 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.852398e-01 0.233 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.884444e-01 0.230 0 0
Removal of the Flap Intermediate R-HSA-69166 5.886026e-01 0.230 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.886026e-01 0.230 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.886026e-01 0.230 0 0
Malate-aspartate shuttle R-HSA-9856872 5.886026e-01 0.230 0 0
HIV Transcription Elongation R-HSA-167169 5.889390e-01 0.230 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.889390e-01 0.230 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.889390e-01 0.230 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.889390e-01 0.230 0 0
Mitochondrial protein degradation R-HSA-9837999 5.917560e-01 0.228 0 0
LDL clearance R-HSA-8964038 5.945720e-01 0.226 0 0
Innate Immune System R-HSA-168249 5.962600e-01 0.225 1 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.968236e-01 0.224 0 0
tRNA processing R-HSA-72306 5.987889e-01 0.223 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.178724e-01 0.209 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.178724e-01 0.209 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.178724e-01 0.209 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.181054e-01 0.209 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.181054e-01 0.209 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.181054e-01 0.209 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.181054e-01 0.209 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.181054e-01 0.209 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.181054e-01 0.209 0 0
GABA receptor activation R-HSA-977443 6.193439e-01 0.208 0 0
G-protein beta:gamma signalling R-HSA-397795 6.211832e-01 0.207 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.211832e-01 0.207 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.211832e-01 0.207 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.236524e-01 0.205 0 0
Translation of Structural Proteins R-HSA-9683701 6.252655e-01 0.204 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.284576e-01 0.202 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.284576e-01 0.202 0 0
STAT5 Activation R-HSA-9645135 6.284576e-01 0.202 0 0
Uncoating of the HIV Virion R-HSA-162585 6.284576e-01 0.202 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.284576e-01 0.202 0 0
Abacavir transmembrane transport R-HSA-2161517 6.284576e-01 0.202 0 0
Lactose synthesis R-HSA-5653890 6.284576e-01 0.202 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.284576e-01 0.202 0 0
Chylomicron clearance R-HSA-8964026 6.284576e-01 0.202 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.284576e-01 0.202 0 0
HDL clearance R-HSA-8964011 6.284576e-01 0.202 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.284576e-01 0.202 0 0
VLDL assembly R-HSA-8866423 6.284576e-01 0.202 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.284576e-01 0.202 0 0
Neurofascin interactions R-HSA-447043 6.284576e-01 0.202 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.406934e-01 0.193 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.406934e-01 0.193 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.406934e-01 0.193 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.407127e-01 0.193 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.455117e-01 0.190 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.455117e-01 0.190 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.455117e-01 0.190 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.455117e-01 0.190 0 0
Killing mechanisms R-HSA-9664420 6.455117e-01 0.190 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.455117e-01 0.190 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.455762e-01 0.190 0 0
Heme signaling R-HSA-9707616 6.489279e-01 0.188 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.525129e-01 0.185 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.528805e-01 0.185 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.595707e-01 0.181 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.623240e-01 0.179 0 0
TGFBR3 expression R-HSA-9839394 6.623240e-01 0.179 0 0
Tight junction interactions R-HSA-420029 6.623240e-01 0.179 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 6.623240e-01 0.179 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.671744e-01 0.176 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.671744e-01 0.176 0 0
Recycling of eIF2:GDP R-HSA-72731 6.671744e-01 0.176 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.671744e-01 0.176 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.671744e-01 0.176 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.671744e-01 0.176 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.671744e-01 0.176 0 0
VLDL clearance R-HSA-8964046 6.671744e-01 0.176 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.671744e-01 0.176 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.671744e-01 0.176 0 0
LDL remodeling R-HSA-8964041 6.671744e-01 0.176 0 0
Netrin mediated repulsion signals R-HSA-418886 6.671744e-01 0.176 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.671744e-01 0.176 0 0
Stimuli-sensing channels R-HSA-2672351 6.673809e-01 0.176 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.687355e-01 0.175 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.715425e-01 0.173 0 0
Galactose catabolism R-HSA-70370 6.715425e-01 0.173 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.715425e-01 0.173 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.715425e-01 0.173 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.715425e-01 0.173 0 0
Insulin receptor signalling cascade R-HSA-74751 6.771092e-01 0.169 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.777468e-01 0.169 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.777468e-01 0.169 0 0
PERK regulates gene expression R-HSA-381042 6.777468e-01 0.169 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.829930e-01 0.166 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.829930e-01 0.166 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.829930e-01 0.166 0 0
TRP channels R-HSA-3295583 6.829930e-01 0.166 0 0
Iron uptake and transport R-HSA-917937 6.915389e-01 0.160 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.918173e-01 0.160 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.952351e-01 0.158 0 0
RUNX2 regulates bone development R-HSA-8941326 6.952351e-01 0.158 0 0
Triglyceride catabolism R-HSA-163560 6.952351e-01 0.158 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.959999e-01 0.157 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.959999e-01 0.157 0 0
Choline catabolism R-HSA-6798163 6.959999e-01 0.157 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.959999e-01 0.157 0 0
Specification of primordial germ cells R-HSA-9827857 6.959999e-01 0.157 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.018588e-01 0.154 0 0
Minus-strand DNA synthesis R-HSA-164516 7.018588e-01 0.154 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.018588e-01 0.154 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.018588e-01 0.154 0 0
MET receptor recycling R-HSA-8875656 7.018588e-01 0.154 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.018588e-01 0.154 0 0
Fructose biosynthesis R-HSA-5652227 7.018588e-01 0.154 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.018588e-01 0.154 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.018588e-01 0.154 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.018588e-01 0.154 0 0
Sodium/Proton exchangers R-HSA-425986 7.018588e-01 0.154 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.018588e-01 0.154 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.018588e-01 0.154 0 0
Interleukin-23 signaling R-HSA-9020933 7.018588e-01 0.154 0 0
Cristae formation R-HSA-8949613 7.027034e-01 0.153 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.027034e-01 0.153 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.027034e-01 0.153 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.027034e-01 0.153 0 0
Integration of energy metabolism R-HSA-163685 7.062255e-01 0.151 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.071257e-01 0.151 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.071257e-01 0.151 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 7.160530e-01 0.145 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.165049e-01 0.145 0 0
IRS-mediated signalling R-HSA-112399 7.184060e-01 0.144 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.189290e-01 0.143 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.189290e-01 0.143 0 0
Nephron development R-HSA-9831926 7.189290e-01 0.143 0 0
Tie2 Signaling R-HSA-210993 7.189290e-01 0.143 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.189290e-01 0.143 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.214638e-01 0.142 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.214638e-01 0.142 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.214638e-01 0.142 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.214638e-01 0.142 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.214638e-01 0.142 0 0
Pyroptosis R-HSA-5620971 7.214638e-01 0.142 0 0
MET promotes cell motility R-HSA-8875878 7.281436e-01 0.138 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.329304e-01 0.135 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.329304e-01 0.135 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.329304e-01 0.135 0 0
mRNA Editing R-HSA-75072 7.329304e-01 0.135 0 0
Metal ion SLC transporters R-HSA-425410 7.361204e-01 0.133 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.370352e-01 0.133 0 0
mRNA Capping R-HSA-72086 7.392881e-01 0.131 0 0
Glucagon-type ligand receptors R-HSA-420092 7.392881e-01 0.131 0 0
Metabolism of proteins R-HSA-392499 7.398060e-01 0.131 0 0
Methionine salvage pathway R-HSA-1237112 7.403827e-01 0.131 0 0
Other interleukin signaling R-HSA-449836 7.403827e-01 0.131 0 0
Leishmania phagocytosis R-HSA-9664417 7.412120e-01 0.130 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.412120e-01 0.130 0 0
Parasite infection R-HSA-9664407 7.412120e-01 0.130 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.435701e-01 0.129 0 0
Interferon gamma signaling R-HSA-877300 7.440090e-01 0.128 0 0
Peroxisomal protein import R-HSA-9033241 7.444430e-01 0.128 0 0
Regulation of beta-cell development R-HSA-186712 7.444430e-01 0.128 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.561944e-01 0.121 0 0
Neurotransmitter clearance R-HSA-112311 7.561944e-01 0.121 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.567929e-01 0.121 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.583205e-01 0.120 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.583205e-01 0.120 0 0
Diseases of Immune System R-HSA-5260271 7.583205e-01 0.120 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.604194e-01 0.119 0 0
Signaling by NODAL R-HSA-1181150 7.604194e-01 0.119 0 0
Creatine metabolism R-HSA-71288 7.604194e-01 0.119 0 0
Metabolism of serotonin R-HSA-380612 7.607655e-01 0.119 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.607655e-01 0.119 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.607655e-01 0.119 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.607655e-01 0.119 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.607655e-01 0.119 0 0
Serotonin receptors R-HSA-390666 7.607655e-01 0.119 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.629615e-01 0.117 0 0
Azathioprine ADME R-HSA-9748787 7.629615e-01 0.117 0 0
FOXO-mediated transcription R-HSA-9614085 7.669478e-01 0.115 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.686997e-01 0.114 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.724047e-01 0.112 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.749080e-01 0.111 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.791014e-01 0.108 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.791014e-01 0.108 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.791014e-01 0.108 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.801671e-01 0.108 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.801671e-01 0.108 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.812770e-01 0.107 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.857009e-01 0.105 0 0
LGI-ADAM interactions R-HSA-5682910 7.857009e-01 0.105 0 0
vRNA Synthesis R-HSA-192814 7.857009e-01 0.105 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.857009e-01 0.105 0 0
vRNP Assembly R-HSA-192905 7.857009e-01 0.105 0 0
Chylomicron assembly R-HSA-8963888 7.857009e-01 0.105 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.857009e-01 0.105 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.857009e-01 0.105 0 0
Interleukin-2 signaling R-HSA-9020558 7.857009e-01 0.105 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.857009e-01 0.105 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.858349e-01 0.105 0 0
HIV Transcription Initiation R-HSA-167161 7.858349e-01 0.105 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.858349e-01 0.105 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.873429e-01 0.104 0 0
Signaling by Insulin receptor R-HSA-74752 7.876444e-01 0.104 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.876859e-01 0.104 0 0
Neurexins and neuroligins R-HSA-6794361 7.876859e-01 0.104 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.964933e-01 0.099 0 0
Serine metabolism R-HSA-977347 7.964933e-01 0.099 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.964933e-01 0.099 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.964933e-01 0.099 0 0
Ribavirin ADME R-HSA-9755088 7.964933e-01 0.099 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.986251e-01 0.098 0 0
Nucleotide biosynthesis R-HSA-8956320 7.992729e-01 0.097 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.004117e-01 0.097 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.016368e-01 0.096 0 0
IGF1R signaling cascade R-HSA-2428924 8.018032e-01 0.096 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.080387e-01 0.093 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.080387e-01 0.093 0 0
ERKs are inactivated R-HSA-202670 8.080387e-01 0.093 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.080387e-01 0.093 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.080387e-01 0.093 0 0
Plasmalogen biosynthesis R-HSA-75896 8.080387e-01 0.093 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.080387e-01 0.093 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.080387e-01 0.093 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.080387e-01 0.093 0 0
Sodium/Calcium exchangers R-HSA-425561 8.080387e-01 0.093 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.107906e-01 0.091 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.119843e-01 0.090 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.126611e-01 0.090 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.126611e-01 0.090 0 0
Fructose metabolism R-HSA-5652084 8.126611e-01 0.090 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.126611e-01 0.090 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.126611e-01 0.090 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.126611e-01 0.090 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.126611e-01 0.090 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.151149e-01 0.089 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.151149e-01 0.089 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.151149e-01 0.089 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.151149e-01 0.089 0 0
RSV-host interactions R-HSA-9833110 8.185395e-01 0.087 0 0
Adipogenesis R-HSA-9843745 8.189018e-01 0.087 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.238424e-01 0.084 0 0
Translation of Structural Proteins R-HSA-9694635 8.238424e-01 0.084 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.276710e-01 0.082 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.276710e-01 0.082 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.278074e-01 0.082 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.280492e-01 0.082 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.280492e-01 0.082 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.280492e-01 0.082 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.280492e-01 0.082 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.280492e-01 0.082 0 0
Signaling by LTK R-HSA-9842663 8.280492e-01 0.082 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.280492e-01 0.082 0 0
Regulation of IFNG signaling R-HSA-877312 8.280492e-01 0.082 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.280492e-01 0.082 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.280492e-01 0.082 0 0
Interleukin-15 signaling R-HSA-8983432 8.280492e-01 0.082 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.280492e-01 0.082 0 0
OAS antiviral response R-HSA-8983711 8.280492e-01 0.082 0 0
Integrin cell surface interactions R-HSA-216083 8.325527e-01 0.080 0 0
G alpha (s) signalling events R-HSA-418555 8.331699e-01 0.079 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.333164e-01 0.079 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.415885e-01 0.075 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.415885e-01 0.075 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.415885e-01 0.075 0 0
Complex III assembly R-HSA-9865881 8.415885e-01 0.075 0 0
Signaling by TGFBR3 R-HSA-9839373 8.437132e-01 0.074 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.437132e-01 0.074 0 0
Formation of axial mesoderm R-HSA-9796292 8.459748e-01 0.073 0 0
Processing of SMDT1 R-HSA-8949664 8.459748e-01 0.073 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.459748e-01 0.073 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.459748e-01 0.073 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.459748e-01 0.073 0 0
Maturation of nucleoprotein R-HSA-9683610 8.459748e-01 0.073 0 0
GPVI-mediated activation cascade R-HSA-114604 8.509606e-01 0.070 0 0
Glycosphingolipid transport R-HSA-9845576 8.509606e-01 0.070 0 0
Laminin interactions R-HSA-3000157 8.544783e-01 0.068 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.544783e-01 0.068 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.544783e-01 0.068 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.547336e-01 0.068 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.566450e-01 0.067 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.620327e-01 0.064 0 0
cGMP effects R-HSA-418457 8.620327e-01 0.064 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.620327e-01 0.064 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.620327e-01 0.064 0 0
Signal regulatory protein family interactions R-HSA-391160 8.620327e-01 0.064 0 0
P2Y receptors R-HSA-417957 8.620327e-01 0.064 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.659002e-01 0.063 0 0
MET activates PTK2 signaling R-HSA-8874081 8.664033e-01 0.062 0 0
Urea cycle R-HSA-70635 8.664033e-01 0.062 0 0
RAB geranylgeranylation R-HSA-8873719 8.669120e-01 0.062 0 0
tRNA Aminoacylation R-HSA-379724 8.669120e-01 0.062 0 0
Metabolism of polyamines R-HSA-351202 8.669120e-01 0.062 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.711287e-01 0.060 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.713511e-01 0.060 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.764173e-01 0.057 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.764173e-01 0.057 0 0
Protein lipoylation R-HSA-9857492 8.764173e-01 0.057 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.764173e-01 0.057 0 0
Protein repair R-HSA-5676934 8.764173e-01 0.057 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.764173e-01 0.057 0 0
Transport and metabolism of PAPS R-HSA-174362 8.764173e-01 0.057 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.764173e-01 0.057 0 0
Other semaphorin interactions R-HSA-416700 8.764173e-01 0.057 0 0
Signaling by Activin R-HSA-1502540 8.764173e-01 0.057 0 0
DNA Damage Reversal R-HSA-73942 8.764173e-01 0.057 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.774245e-01 0.057 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.792512e-01 0.056 0 0
PI3K Cascade R-HSA-109704 8.799815e-01 0.056 0 0
Pentose phosphate pathway R-HSA-71336 8.805901e-01 0.055 0 0
Signaling by PDGF R-HSA-186797 8.822941e-01 0.054 0 0
Metabolism of amino acids and derivatives R-HSA-71291 8.847413e-01 0.053 0 0
Insulin receptor recycling R-HSA-77387 8.876008e-01 0.052 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.876008e-01 0.052 0 0
The phototransduction cascade R-HSA-2514856 8.878195e-01 0.052 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.893029e-01 0.051 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.893029e-01 0.051 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.893029e-01 0.051 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.893029e-01 0.051 0 0
Fructose catabolism R-HSA-70350 8.893029e-01 0.051 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.893029e-01 0.051 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.893029e-01 0.051 0 0
Activation of SMO R-HSA-5635838 8.893029e-01 0.051 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.893029e-01 0.051 0 0
Mitochondrial Uncoupling R-HSA-166187 8.893029e-01 0.051 0 0
Attachment and Entry R-HSA-9678110 8.893029e-01 0.051 0 0
Atorvastatin ADME R-HSA-9754706 8.893029e-01 0.051 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.924921e-01 0.049 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.006131e-01 0.045 0 0
Potassium Channels R-HSA-1296071 9.006131e-01 0.045 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.008456e-01 0.045 0 0
Glycine degradation R-HSA-6783984 9.008456e-01 0.045 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.008456e-01 0.045 0 0
Fibronectin matrix formation R-HSA-1566977 9.008456e-01 0.045 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.008456e-01 0.045 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.008456e-01 0.045 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.008456e-01 0.045 0 0
Passive transport by Aquaporins R-HSA-432047 9.008456e-01 0.045 0 0
Coenzyme A biosynthesis R-HSA-196783 9.008456e-01 0.045 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.021622e-01 0.045 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.056412e-01 0.043 0 0
Mitochondrial biogenesis R-HSA-1592230 9.094244e-01 0.041 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.107018e-01 0.041 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.111853e-01 0.040 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.111853e-01 0.040 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.111853e-01 0.040 0 0
Catecholamine biosynthesis R-HSA-209905 9.111853e-01 0.040 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.111853e-01 0.040 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.118963e-01 0.040 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.136102e-01 0.039 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.136102e-01 0.039 0 0
Paracetamol ADME R-HSA-9753281 9.148591e-01 0.039 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.204474e-01 0.036 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.204474e-01 0.036 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.204474e-01 0.036 0 0
Signaling by WNT in cancer R-HSA-4791275 9.209440e-01 0.036 0 0
Gastrulation R-HSA-9758941 9.220865e-01 0.035 0 0
Surfactant metabolism R-HSA-5683826 9.245722e-01 0.034 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.267887e-01 0.033 0 0
Cardiogenesis R-HSA-9733709 9.276883e-01 0.033 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.276883e-01 0.033 0 0
PI Metabolism R-HSA-1483255 9.282775e-01 0.032 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.287441e-01 0.032 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.287441e-01 0.032 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.287441e-01 0.032 0 0
Pyrimidine biosynthesis R-HSA-500753 9.287441e-01 0.032 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.287441e-01 0.032 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.287441e-01 0.032 0 0
Maturation of nucleoprotein R-HSA-9694631 9.287441e-01 0.032 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.321530e-01 0.031 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.327910e-01 0.030 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.327910e-01 0.030 0 0
Heme degradation R-HSA-189483 9.338863e-01 0.030 0 0
Triglyceride metabolism R-HSA-8979227 9.359220e-01 0.029 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.361759e-01 0.029 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.361759e-01 0.029 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.361759e-01 0.029 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.361759e-01 0.029 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.361759e-01 0.029 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.361759e-01 0.029 0 0
Pregnenolone biosynthesis R-HSA-196108 9.361759e-01 0.029 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.361759e-01 0.029 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.395785e-01 0.027 0 0
Synthesis of PC R-HSA-1483191 9.404752e-01 0.027 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.413570e-01 0.026 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.428330e-01 0.026 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.428330e-01 0.026 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.428330e-01 0.026 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.428330e-01 0.026 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.428330e-01 0.026 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.428330e-01 0.026 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.448031e-01 0.025 0 0
NGF-stimulated transcription R-HSA-9031628 9.450449e-01 0.025 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.457471e-01 0.024 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.487961e-01 0.023 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.487961e-01 0.023 0 0
Attachment and Entry R-HSA-9694614 9.487961e-01 0.023 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.495955e-01 0.022 0 0
RNA Polymerase III Transcription R-HSA-74158 9.495955e-01 0.022 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.521413e-01 0.021 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.541375e-01 0.020 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.541375e-01 0.020 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.541375e-01 0.020 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.541375e-01 0.020 0 0
Cellular hexose transport R-HSA-189200 9.541375e-01 0.020 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.541375e-01 0.020 0 0
Ethanol oxidation R-HSA-71384 9.541375e-01 0.020 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.580149e-01 0.019 0 0
Elastic fibre formation R-HSA-1566948 9.580149e-01 0.019 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.589219e-01 0.018 0 0
Biosynthesis of maresins R-HSA-9018682 9.589219e-01 0.018 0 0
Formation of the ureteric bud R-HSA-9830674 9.589219e-01 0.018 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.589219e-01 0.018 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.589219e-01 0.018 0 0
Ketone body metabolism R-HSA-74182 9.589219e-01 0.018 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.617018e-01 0.017 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.618034e-01 0.017 0 0
CYP2E1 reactions R-HSA-211999 9.632075e-01 0.016 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.632075e-01 0.016 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.650768e-01 0.015 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.650768e-01 0.015 0 0
Interleukin-2 family signaling R-HSA-451927 9.650768e-01 0.015 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.650768e-01 0.015 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.670463e-01 0.015 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.670463e-01 0.015 0 0
Hyaluronan degradation R-HSA-2160916 9.670463e-01 0.015 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.670463e-01 0.015 0 0
Maturation of spike protein R-HSA-9694548 9.681646e-01 0.014 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.682937e-01 0.014 0 0
Abacavir ADME R-HSA-2161522 9.704847e-01 0.013 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.704847e-01 0.013 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.709885e-01 0.013 0 0
Intra-Golgi traffic R-HSA-6811438 9.709885e-01 0.013 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.709885e-01 0.013 0 0
COPII-mediated vesicle transport R-HSA-204005 9.717500e-01 0.012 0 0
Signaling by BMP R-HSA-201451 9.735645e-01 0.012 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.735645e-01 0.012 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.735645e-01 0.012 0 0
Dectin-2 family R-HSA-5621480 9.737230e-01 0.012 0 0
Peptide hormone metabolism R-HSA-2980736 9.752089e-01 0.011 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.758373e-01 0.011 0 0
Prednisone ADME R-HSA-9757110 9.763231e-01 0.010 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.777893e-01 0.010 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.780833e-01 0.010 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.780833e-01 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.787940e-01 0.009 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.787940e-01 0.009 0 0
G alpha (q) signalling events R-HSA-416476 9.790794e-01 0.009 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.807163e-01 0.008 0 0
Neddylation R-HSA-8951664 9.807489e-01 0.008 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.808341e-01 0.008 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.810072e-01 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.810072e-01 0.008 0 0
Post-translational protein modification R-HSA-597592 9.810882e-01 0.008 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.829895e-01 0.007 0 0
Formation of the cornified envelope R-HSA-6809371 9.840800e-01 0.007 0 0
DAG1 glycosylations R-HSA-8931838 9.847650e-01 0.007 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.863402e-01 0.006 0 0
Recycling of bile acids and salts R-HSA-159418 9.863553e-01 0.006 0 0
Extracellular matrix organization R-HSA-1474244 9.875554e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.877797e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.877797e-01 0.005 0 0
Complex IV assembly R-HSA-9864848 9.887132e-01 0.005 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.888080e-01 0.005 0 0
Kidney development R-HSA-9830369 9.888080e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.889693e-01 0.005 0 0
eNOS activation R-HSA-203615 9.890554e-01 0.005 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.890554e-01 0.005 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.890554e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.890554e-01 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 9.890554e-01 0.005 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.897358e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.897405e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.901980e-01 0.004 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.901980e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.912215e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.912215e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.921101e-01 0.003 0 0
ECM proteoglycans R-HSA-3000178 9.921101e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.921101e-01 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 9.921381e-01 0.003 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.921381e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.921381e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.921381e-01 0.003 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.929590e-01 0.003 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.936943e-01 0.003 0 0
Transport of small molecules R-HSA-382551 9.939393e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.947487e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.947487e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.947830e-01 0.002 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.952834e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.954708e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.954708e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.957065e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.962417e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.963249e-01 0.002 0 0
Pyrimidine catabolism R-HSA-73621 9.963676e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.964690e-01 0.002 0 0
Methylation R-HSA-156581 9.967470e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.967922e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.967986e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.970869e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.973697e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.978402e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.979079e-01 0.001 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.981241e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.981265e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.983118e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.983223e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.984752e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.984976e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.986837e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.988083e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.988992e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.991025e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.991349e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.992004e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.992004e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.993735e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.994438e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995020e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996065e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.996903e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997433e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997433e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997662e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998158e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998223e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998350e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998502e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998748e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.998808e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998816e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999043e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999239e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999295e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999319e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999319e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999454e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999524e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999570e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999608e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999700e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999768e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999855e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999875e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999897e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999925e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999928e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999933e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999940e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999966e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999970e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999972e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999979e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999984e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999986e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999987e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999996e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999997e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999997e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999998e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999998e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways