Motif 992 (n=61)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00141 | SGK1 | S255 | ochoa | Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. {ECO:0000269|PubMed:11154281, ECO:0000269|PubMed:11410590, ECO:0000269|PubMed:11696533, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12761204, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15234985, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15733869, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16443776, ECO:0000269|PubMed:16982696, ECO:0000269|PubMed:17382906, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:18753299, ECO:0000269|PubMed:19447520, ECO:0000269|PubMed:19756449, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:20730100, ECO:0000269|PubMed:21865597}. |
| O60814 | H2BC12 | T89 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O75676 | RPS6KA4 | T194 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O75914 | PAK3 | S435 | ochoa | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| P06493 | CDK1 | T161 | ochoa|psp | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P21127 | CDK11B | T595 | ochoa|psp | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P24941 | CDK2 | T160 | ochoa|psp | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}. |
| P29317 | EPHA2 | Y772 | ochoa|psp | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29320 | EPHA3 | Y779 | ochoa|psp | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| P29323 | EPHB2 | T779 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P41743 | PRKCI | S411 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P43403 | ZAP70 | T494 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P49840 | GSK3A | S278 | ochoa|psp | Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). {ECO:0000250|UniProtKB:P18265, ECO:0000250|UniProtKB:P49841, ECO:0000250|UniProtKB:Q2NL51, ECO:0000269|PubMed:10868943, ECO:0000269|PubMed:12761548, ECO:0000269|PubMed:17229088, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:30704899, ECO:0000303|PubMed:11749387, ECO:0000303|PubMed:17478001, ECO:0000303|PubMed:19366350}. |
| P49841 | GSK3B | S215 | ochoa | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:11430833, PubMed:12554650, PubMed:14690523, PubMed:16484495, PubMed:1846781, PubMed:20937854, PubMed:9072970). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282, PubMed:25827072, PubMed:29059170). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (PubMed:21343617). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
| P50613 | CDK7 | T170 | ochoa|psp | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) | Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, PubMed:28768201). CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| P51812 | RPS6KA3 | Y226 | ochoa | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| P54753 | EPHB3 | T791 | ochoa | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
| P54756 | EPHA5 | Y833 | ochoa | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}. |
| P54760 | EPHB4 | T773 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P54764 | EPHA4 | Y779 | ochoa|psp | Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (By similarity). {ECO:0000250|UniProtKB:Q03137, ECO:0000269|PubMed:17143272}. |
| P57053 | H2BC12L | T89 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | T89 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62807 | H2BC4 | T89 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q00526 | CDK3 | T160 | ochoa | Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. {ECO:0000269|PubMed:15084261, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:8846921}. |
| Q00535 | CDK5 | S159 | psp | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q03114, ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}. |
| Q05513 | PRKCZ | S409 | ochoa | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q05655 | PRKCD | S506 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q06187 | BTK | S554 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08881 | ITK | S515 | ochoa | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q13153 | PAK1 | S422 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13177 | PAK2 | S401 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13523 | PRP4K | Y849 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14164 | IKBKE | S172 | psp | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q15131 | CDK10 | T196 | ochoa | Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE) | Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). {ECO:0000269|PubMed:24218572, ECO:0000269|PubMed:27104747}. |
| Q15375 | EPHA7 | Y791 | ochoa | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
| Q15418 | RPS6KA1 | Y220 | ochoa | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q16512 | PKN1 | S773 | ochoa|psp | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q16513 | PKN2 | S815 | ochoa|psp | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16778 | H2BC21 | T89 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q52WX2 | SBK1 | S209 | ochoa | Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3 domain-binding kinase 1) | May be involved in signal-transduction pathways related to the control of brain development. {ECO:0000250}. |
| Q5QNW6 | H2BC18 | T89 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6P5Z2 | PKN3 | S717 | ochoa | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Q86Z02 | HIPK1 | Y352 | ochoa | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q8N4S9 | MARVELD2 | T166 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q93079 | H2BC9 | T89 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99877 | H2BC15 | T89 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | T89 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | T89 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9H2X6 | HIPK2 | Y361 | ochoa|psp | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H422 | HIPK3 | Y359 | ochoa | Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}. |
| Q9NRP7 | STK36 | T158 | ochoa | Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:28543983}. |
| Q9NSY1 | BMP2K | T1137 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9UHD2 | TBK1 | S172 | ochoa|psp | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UK32 | RPS6KA6 | Y231 | ochoa | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9UQ88 | CDK11A | T583 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2U5 | MAP3K2 | T516 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| O00444 | PLK4 | Y169 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| P29322 | EPHA8 | Y793 | Sugiyama | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| P07332 | FES | S716 | Sugiyama | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| Q13163 | MAP2K5 | Y316 | Sugiyama | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:Q62862, ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}. |
| Q96PN8 | TSSK3 | S166 | SIGNOR | Testis-specific serine/threonine-protein kinase 3 (TSK-3) (TSSK-3) (Testis-specific kinase 3) (EC 2.7.11.1) (Serine/threonine-protein kinase 22C) | Serine/threonine protein kinase required for spermatid development and male fertility. {ECO:0000250|UniProtKB:Q9D2E1}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.220446e-16 | 15.654 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.220446e-16 | 15.654 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.440892e-16 | 15.353 |
| R-HSA-171306 | Packaging Of Telomere Ends | 6.661338e-16 | 15.176 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 6.661338e-16 | 15.176 |
| R-HSA-5334118 | DNA methylation | 1.110223e-15 | 14.955 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.554312e-15 | 14.808 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.553513e-15 | 14.593 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.219647e-15 | 14.492 |
| R-HSA-912446 | Meiotic recombination | 3.885781e-15 | 14.411 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.662937e-15 | 14.331 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.329071e-15 | 14.273 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.329071e-15 | 14.273 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.662137e-15 | 14.247 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 8.548717e-15 | 14.068 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.065814e-14 | 13.972 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.065814e-14 | 13.972 |
| R-HSA-73927 | Depurination | 1.332268e-14 | 13.875 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.042810e-14 | 13.690 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.042810e-14 | 13.690 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.509104e-14 | 13.600 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.486900e-14 | 13.604 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.486900e-14 | 13.604 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.752554e-14 | 13.426 |
| R-HSA-73928 | Depyrimidination | 3.752554e-14 | 13.426 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.507505e-14 | 13.346 |
| R-HSA-9710421 | Defective pyroptosis | 4.551914e-14 | 13.342 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 6.639134e-14 | 13.178 |
| R-HSA-774815 | Nucleosome assembly | 6.639134e-14 | 13.178 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 9.103829e-14 | 13.041 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 9.103829e-14 | 13.041 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.140199e-13 | 12.943 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.356693e-13 | 12.868 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.756373e-13 | 12.755 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.259304e-13 | 12.646 |
| R-HSA-1221632 | Meiotic synapsis | 2.634559e-13 | 12.579 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.888800e-13 | 12.539 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.089751e-13 | 12.510 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.259615e-13 | 12.487 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.612666e-13 | 12.442 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.646283e-13 | 12.333 |
| R-HSA-1500620 | Meiosis | 5.214718e-13 | 12.283 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.692113e-13 | 12.245 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.592504e-13 | 12.181 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.619461e-13 | 12.118 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.619461e-13 | 12.118 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.172352e-13 | 12.088 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.130651e-12 | 11.947 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.737721e-12 | 11.760 |
| R-HSA-1266738 | Developmental Biology | 1.907918e-12 | 11.719 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.980416e-12 | 11.703 |
| R-HSA-69481 | G2/M Checkpoints | 2.081668e-12 | 11.682 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.252976e-12 | 11.647 |
| R-HSA-157579 | Telomere Maintenance | 2.563727e-12 | 11.591 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.900791e-12 | 11.537 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.900791e-12 | 11.537 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.710476e-12 | 11.431 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.435563e-12 | 11.353 |
| R-HSA-422475 | Axon guidance | 4.607204e-12 | 11.337 |
| R-HSA-2559583 | Cellular Senescence | 5.633605e-12 | 11.249 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.553935e-12 | 11.068 |
| R-HSA-977225 | Amyloid fiber formation | 1.044032e-11 | 10.981 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.206368e-11 | 10.919 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.312295e-11 | 10.882 |
| R-HSA-9675108 | Nervous system development | 1.362022e-11 | 10.866 |
| R-HSA-5693538 | Homology Directed Repair | 2.143796e-11 | 10.669 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.218792e-11 | 10.654 |
| R-HSA-68875 | Mitotic Prophase | 2.511846e-11 | 10.600 |
| R-HSA-73886 | Chromosome Maintenance | 2.716427e-11 | 10.566 |
| R-HSA-73884 | Base Excision Repair | 2.923661e-11 | 10.534 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.982548e-11 | 10.400 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.982548e-11 | 10.400 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.982548e-11 | 10.400 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.284006e-11 | 10.368 |
| R-HSA-1474165 | Reproduction | 6.187917e-11 | 10.208 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.065471e-11 | 10.093 |
| R-HSA-3214847 | HATs acetylate histones | 8.067391e-11 | 10.093 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.044761e-10 | 9.981 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.044761e-10 | 9.981 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.343501e-10 | 9.872 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.343501e-10 | 9.872 |
| R-HSA-211000 | Gene Silencing by RNA | 1.716142e-10 | 9.765 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.226466e-10 | 9.491 |
| R-HSA-69306 | DNA Replication | 3.226466e-10 | 9.491 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.314709e-10 | 9.480 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.428202e-10 | 9.465 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.596886e-10 | 9.444 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.589217e-10 | 9.181 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.015785e-09 | 8.993 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.061021e-09 | 8.974 |
| R-HSA-3928664 | Ephrin signaling | 1.223578e-09 | 8.912 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.809704e-09 | 8.742 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.879868e-09 | 8.726 |
| R-HSA-1640170 | Cell Cycle | 2.499280e-09 | 8.602 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.068818e-09 | 8.391 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.147820e-09 | 8.382 |
| R-HSA-8852135 | Protein ubiquitination | 4.446582e-09 | 8.352 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.030622e-08 | 7.987 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.587350e-08 | 7.799 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.587350e-08 | 7.799 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.587350e-08 | 7.799 |
| R-HSA-8939211 | ESR-mediated signaling | 2.110880e-08 | 7.676 |
| R-HSA-157118 | Signaling by NOTCH | 2.373260e-08 | 7.625 |
| R-HSA-421270 | Cell-cell junction organization | 3.602254e-08 | 7.443 |
| R-HSA-5688426 | Deubiquitination | 4.173382e-08 | 7.380 |
| R-HSA-9609690 | HCMV Early Events | 4.538351e-08 | 7.343 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.538351e-08 | 7.343 |
| R-HSA-162582 | Signal Transduction | 4.843317e-08 | 7.315 |
| R-HSA-446728 | Cell junction organization | 9.315645e-08 | 7.031 |
| R-HSA-9610379 | HCMV Late Events | 9.707637e-08 | 7.013 |
| R-HSA-418990 | Adherens junctions interactions | 1.156424e-07 | 6.937 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.214451e-07 | 6.916 |
| R-HSA-73894 | DNA Repair | 1.228898e-07 | 6.910 |
| R-HSA-195721 | Signaling by WNT | 1.774531e-07 | 6.751 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.095126e-07 | 6.679 |
| R-HSA-68886 | M Phase | 2.295854e-07 | 6.639 |
| R-HSA-1500931 | Cell-Cell communication | 3.052805e-07 | 6.515 |
| R-HSA-4839726 | Chromatin organization | 3.527305e-07 | 6.453 |
| R-HSA-9609646 | HCMV Infection | 3.647769e-07 | 6.438 |
| R-HSA-2262752 | Cellular responses to stress | 5.260402e-07 | 6.279 |
| R-HSA-373755 | Semaphorin interactions | 8.946451e-07 | 6.048 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.092689e-06 | 5.962 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.870087e-06 | 5.728 |
| R-HSA-202433 | Generation of second messenger molecules | 2.518410e-06 | 5.599 |
| R-HSA-1280218 | Adaptive Immune System | 3.630856e-06 | 5.440 |
| R-HSA-9824446 | Viral Infection Pathways | 9.564836e-06 | 5.019 |
| R-HSA-212436 | Generic Transcription Pathway | 1.263121e-05 | 4.899 |
| R-HSA-444257 | RSK activation | 1.835087e-05 | 4.736 |
| R-HSA-373760 | L1CAM interactions | 2.741222e-05 | 4.562 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.423380e-05 | 4.354 |
| R-HSA-428540 | Activation of RAC1 | 4.593902e-05 | 4.338 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 6.644629e-05 | 4.178 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 7.862305e-05 | 4.104 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 9.388625e-05 | 4.027 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.153857e-04 | 3.938 |
| R-HSA-437239 | Recycling pathway of L1 | 1.163214e-04 | 3.934 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.527004e-04 | 3.816 |
| R-HSA-202403 | TCR signaling | 2.290750e-04 | 3.640 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.412807e-04 | 3.467 |
| R-HSA-69275 | G2/M Transition | 3.242262e-04 | 3.489 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.955663e-04 | 3.529 |
| R-HSA-74160 | Gene expression (Transcription) | 3.417797e-04 | 3.466 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.502798e-04 | 3.456 |
| R-HSA-194138 | Signaling by VEGF | 4.284486e-04 | 3.368 |
| R-HSA-5663205 | Infectious disease | 4.290831e-04 | 3.367 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.714709e-04 | 3.327 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.787645e-04 | 3.320 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.014712e-04 | 3.300 |
| R-HSA-380287 | Centrosome maturation | 5.491700e-04 | 3.260 |
| R-HSA-1538133 | G0 and Early G1 | 6.939056e-04 | 3.159 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 7.477506e-04 | 3.126 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.477506e-04 | 3.126 |
| R-HSA-168256 | Immune System | 7.645717e-04 | 3.117 |
| R-HSA-199920 | CREB phosphorylation | 7.778952e-04 | 3.109 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 8.371000e-04 | 3.077 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 9.053823e-04 | 3.043 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.182607e-04 | 3.037 |
| R-HSA-166520 | Signaling by NTRKs | 9.182607e-04 | 3.037 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 9.895191e-04 | 3.005 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.155347e-03 | 2.937 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.199877e-03 | 2.921 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.354621e-03 | 2.868 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.935232e-03 | 2.713 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.096966e-03 | 2.678 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.123713e-03 | 2.673 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.123713e-03 | 2.673 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.249979e-03 | 2.648 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.249979e-03 | 2.648 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.409356e-03 | 2.618 |
| R-HSA-1643685 | Disease | 2.477436e-03 | 2.606 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.558290e-03 | 2.592 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.712107e-03 | 2.567 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 4.091133e-03 | 2.388 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 4.091133e-03 | 2.388 |
| R-HSA-69206 | G1/S Transition | 3.674360e-03 | 2.435 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 3.721477e-03 | 2.429 |
| R-HSA-5578768 | Physiological factors | 3.031813e-03 | 2.518 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 3.031813e-03 | 2.518 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 5.297596e-03 | 2.276 |
| R-HSA-9694631 | Maturation of nucleoprotein | 5.297596e-03 | 2.276 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.060292e-03 | 2.218 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 6.181672e-03 | 2.209 |
| R-HSA-198753 | ERK/MAPK targets | 6.181672e-03 | 2.209 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.388020e-03 | 2.195 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 6.647202e-03 | 2.177 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 7.624523e-03 | 2.118 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 8.662576e-03 | 2.062 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 8.903119e-03 | 2.050 |
| R-HSA-438064 | Post NMDA receptor activation events | 9.305618e-03 | 2.031 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.038590e-02 | 1.984 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.055708e-02 | 1.976 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.091638e-02 | 1.962 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.132356e-02 | 1.946 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.212992e-02 | 1.916 |
| R-HSA-397795 | G-protein beta:gamma signalling | 1.339976e-02 | 1.873 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.438383e-02 | 1.842 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.472485e-02 | 1.832 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.610411e-02 | 1.793 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 1.681374e-02 | 1.774 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.770082e-02 | 1.752 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 1.772806e-02 | 1.751 |
| R-HSA-198765 | Signalling to ERK5 | 1.772806e-02 | 1.751 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 2.647551e-02 | 1.577 |
| R-HSA-68911 | G2 Phase | 3.082038e-02 | 1.511 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 3.514613e-02 | 1.454 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 3.945284e-02 | 1.404 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 3.945284e-02 | 1.404 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.054401e-02 | 1.392 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.054401e-02 | 1.392 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 3.082038e-02 | 1.511 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 2.211143e-02 | 1.655 |
| R-HSA-176417 | Phosphorylation of Emi1 | 3.514613e-02 | 1.454 |
| R-HSA-69242 | S Phase | 3.862241e-02 | 1.413 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.952172e-02 | 1.403 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 3.082038e-02 | 1.511 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 3.945284e-02 | 1.404 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.202362e-02 | 1.657 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.202362e-02 | 1.657 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.332727e-02 | 1.632 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.332727e-02 | 1.632 |
| R-HSA-164944 | Nef and signal transduction | 3.945284e-02 | 1.404 |
| R-HSA-416476 | G alpha (q) signalling events | 3.866833e-02 | 1.413 |
| R-HSA-69236 | G1 Phase | 2.295371e-02 | 1.639 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.295371e-02 | 1.639 |
| R-HSA-9824272 | Somitogenesis | 2.377720e-02 | 1.624 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.054401e-02 | 1.392 |
| R-HSA-75153 | Apoptotic execution phase | 2.461272e-02 | 1.609 |
| R-HSA-9031628 | NGF-stimulated transcription | 2.631938e-02 | 1.580 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.456378e-02 | 1.461 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.850952e-02 | 1.414 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.987187e-02 | 1.525 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.078830e-02 | 1.512 |
| R-HSA-450294 | MAP kinase activation | 3.850952e-02 | 1.414 |
| R-HSA-9683701 | Translation of Structural Proteins | 2.055666e-02 | 1.687 |
| R-HSA-75893 | TNF signaling | 3.360367e-02 | 1.474 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.461272e-02 | 1.609 |
| R-HSA-397014 | Muscle contraction | 2.042734e-02 | 1.690 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.987187e-02 | 1.525 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.071345e-02 | 1.684 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.631938e-02 | 1.580 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.037529e-02 | 1.394 |
| R-HSA-597592 | Post-translational protein modification | 3.432450e-02 | 1.464 |
| R-HSA-73887 | Death Receptor Signaling | 4.216807e-02 | 1.375 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.261845e-02 | 1.370 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.367038e-02 | 1.360 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 4.374059e-02 | 1.359 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.797370e-02 | 1.319 |
| R-HSA-448424 | Interleukin-17 signaling | 4.797370e-02 | 1.319 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.907292e-02 | 1.309 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.907292e-02 | 1.309 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.907292e-02 | 1.309 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.018129e-02 | 1.299 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 5.225955e-02 | 1.282 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 5.225955e-02 | 1.282 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 5.225955e-02 | 1.282 |
| R-HSA-9020591 | Interleukin-12 signaling | 5.470426e-02 | 1.262 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.581379e-02 | 1.253 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.585688e-02 | 1.253 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 5.649092e-02 | 1.248 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 6.070366e-02 | 1.217 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 6.070366e-02 | 1.217 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 6.070366e-02 | 1.217 |
| R-HSA-4839744 | Signaling by APC mutants | 6.070366e-02 | 1.217 |
| R-HSA-9635465 | Suppression of apoptosis | 6.070366e-02 | 1.217 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.415938e-02 | 1.193 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 6.489785e-02 | 1.188 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 6.489785e-02 | 1.188 |
| R-HSA-4839735 | Signaling by AXIN mutants | 6.489785e-02 | 1.188 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 6.489785e-02 | 1.188 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.783784e-02 | 1.169 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 6.907357e-02 | 1.161 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 6.907357e-02 | 1.161 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 6.907357e-02 | 1.161 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 6.907357e-02 | 1.161 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 6.907357e-02 | 1.161 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 6.907357e-02 | 1.161 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 6.907357e-02 | 1.161 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.907935e-02 | 1.161 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.032838e-02 | 1.153 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.284867e-02 | 1.138 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 7.323090e-02 | 1.135 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 7.323090e-02 | 1.135 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 7.323090e-02 | 1.135 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 7.323090e-02 | 1.135 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.539800e-02 | 1.123 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.668333e-02 | 1.115 |
| R-HSA-168249 | Innate Immune System | 7.734372e-02 | 1.112 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.766320e-02 | 1.110 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.918321e-02 | 1.101 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.058097e-02 | 1.094 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 8.149072e-02 | 1.089 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 8.149072e-02 | 1.089 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 8.149072e-02 | 1.089 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 8.149072e-02 | 1.089 |
| R-HSA-193639 | p75NTR signals via NF-kB | 8.149072e-02 | 1.089 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.230687e-02 | 1.085 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.357338e-02 | 1.078 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 8.559336e-02 | 1.068 |
| R-HSA-176412 | Phosphorylation of the APC/C | 8.559336e-02 | 1.068 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 8.559336e-02 | 1.068 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.587181e-02 | 1.066 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.587181e-02 | 1.066 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.587181e-02 | 1.066 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.595258e-02 | 1.066 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 8.967794e-02 | 1.047 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 8.967794e-02 | 1.047 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 8.967794e-02 | 1.047 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 9.399873e-02 | 1.027 |
| R-HSA-111885 | Opioid Signalling | 9.399873e-02 | 1.027 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 9.779318e-02 | 1.010 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 9.779318e-02 | 1.010 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 9.814328e-02 | 1.008 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.953629e-02 | 1.002 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.953629e-02 | 1.002 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.009349e-01 | 0.996 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.018240e-01 | 0.992 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.018240e-01 | 0.992 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.018240e-01 | 0.992 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.023391e-01 | 0.990 |
| R-HSA-445144 | Signal transduction by L1 | 1.058371e-01 | 0.975 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 1.065841e-01 | 0.972 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.080096e-01 | 0.967 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.094404e-01 | 0.961 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.098325e-01 | 0.959 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.123171e-01 | 0.950 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 1.137629e-01 | 0.944 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.138102e-01 | 0.944 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.138102e-01 | 0.944 |
| R-HSA-9679506 | SARS-CoV Infections | 1.154665e-01 | 0.938 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.177705e-01 | 0.929 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.181293e-01 | 0.928 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.195943e-01 | 0.922 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.217133e-01 | 0.915 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.217133e-01 | 0.915 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.217133e-01 | 0.915 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 1.256387e-01 | 0.901 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.256387e-01 | 0.901 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.256387e-01 | 0.901 |
| R-HSA-420029 | Tight junction interactions | 1.295468e-01 | 0.888 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.373114e-01 | 0.862 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.373114e-01 | 0.862 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.373114e-01 | 0.862 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.373114e-01 | 0.862 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.385816e-01 | 0.858 |
| R-HSA-5576891 | Cardiac conduction | 1.405556e-01 | 0.852 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.411681e-01 | 0.850 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.411681e-01 | 0.850 |
| R-HSA-171319 | Telomere Extension By Telomerase | 1.411681e-01 | 0.850 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.411681e-01 | 0.850 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 1.411681e-01 | 0.850 |
| R-HSA-388396 | GPCR downstream signalling | 1.446667e-01 | 0.840 |
| R-HSA-72086 | mRNA Capping | 1.450078e-01 | 0.839 |
| R-HSA-180024 | DARPP-32 events | 1.450078e-01 | 0.839 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.488305e-01 | 0.827 |
| R-HSA-2424491 | DAP12 signaling | 1.488305e-01 | 0.827 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.488305e-01 | 0.827 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.488305e-01 | 0.827 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.488305e-01 | 0.827 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.526364e-01 | 0.816 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.544234e-01 | 0.811 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.564255e-01 | 0.806 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.564255e-01 | 0.806 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.564255e-01 | 0.806 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.575412e-01 | 0.803 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.601978e-01 | 0.795 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.601978e-01 | 0.795 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.601978e-01 | 0.795 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.606711e-01 | 0.794 |
| R-HSA-449147 | Signaling by Interleukins | 1.626158e-01 | 0.789 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.639536e-01 | 0.785 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.671093e-01 | 0.777 |
| R-HSA-5205647 | Mitophagy | 1.676928e-01 | 0.775 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.676928e-01 | 0.775 |
| R-HSA-169911 | Regulation of Apoptosis | 1.714155e-01 | 0.766 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.714155e-01 | 0.766 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.714155e-01 | 0.766 |
| R-HSA-9758941 | Gastrulation | 1.717149e-01 | 0.765 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.733031e-01 | 0.761 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.733031e-01 | 0.761 |
| R-HSA-111933 | Calmodulin induced events | 1.751217e-01 | 0.757 |
| R-HSA-111997 | CaM pathway | 1.751217e-01 | 0.757 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.751217e-01 | 0.757 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.788117e-01 | 0.748 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.788117e-01 | 0.748 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 1.861427e-01 | 0.730 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.861427e-01 | 0.730 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 1.897840e-01 | 0.722 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 1.897840e-01 | 0.722 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.897840e-01 | 0.722 |
| R-HSA-5260271 | Diseases of Immune System | 1.897840e-01 | 0.722 |
| R-HSA-167169 | HIV Transcription Elongation | 1.897840e-01 | 0.722 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.897840e-01 | 0.722 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.897840e-01 | 0.722 |
| R-HSA-392499 | Metabolism of proteins | 1.899610e-01 | 0.721 |
| R-HSA-109581 | Apoptosis | 1.925405e-01 | 0.715 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.970185e-01 | 0.705 |
| R-HSA-167161 | HIV Transcription Initiation | 1.970185e-01 | 0.705 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.970185e-01 | 0.705 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.970185e-01 | 0.705 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.970185e-01 | 0.705 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.983471e-01 | 0.703 |
| R-HSA-372790 | Signaling by GPCR | 1.986527e-01 | 0.702 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.006118e-01 | 0.698 |
| R-HSA-111996 | Ca-dependent events | 2.006118e-01 | 0.698 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.041893e-01 | 0.690 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.041893e-01 | 0.690 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.041893e-01 | 0.690 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.077509e-01 | 0.682 |
| R-HSA-2172127 | DAP12 interactions | 2.077509e-01 | 0.682 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.112969e-01 | 0.675 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.112969e-01 | 0.675 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.112969e-01 | 0.675 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.112969e-01 | 0.675 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.148272e-01 | 0.668 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.153201e-01 | 0.667 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.170568e-01 | 0.663 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.183860e-01 | 0.661 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.253248e-01 | 0.647 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.253248e-01 | 0.647 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.356841e-01 | 0.628 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.356841e-01 | 0.628 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.356841e-01 | 0.628 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.391067e-01 | 0.621 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.391067e-01 | 0.621 |
| R-HSA-5617833 | Cilium Assembly | 2.399938e-01 | 0.620 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.425142e-01 | 0.615 |
| R-HSA-68877 | Mitotic Prometaphase | 2.449498e-01 | 0.611 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.459066e-01 | 0.609 |
| R-HSA-418597 | G alpha (z) signalling events | 2.459066e-01 | 0.609 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.492841e-01 | 0.603 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.492841e-01 | 0.603 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.526467e-01 | 0.597 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.559944e-01 | 0.592 |
| R-HSA-180786 | Extension of Telomeres | 2.593273e-01 | 0.586 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.626455e-01 | 0.581 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.659490e-01 | 0.575 |
| R-HSA-112043 | PLC beta mediated events | 2.659490e-01 | 0.575 |
| R-HSA-5357801 | Programmed Cell Death | 2.664667e-01 | 0.574 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.692380e-01 | 0.570 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.725124e-01 | 0.565 |
| R-HSA-8848021 | Signaling by PTK6 | 2.725124e-01 | 0.565 |
| R-HSA-112040 | G-protein mediated events | 2.854659e-01 | 0.544 |
| R-HSA-167172 | Transcription of the HIV genome | 2.886686e-01 | 0.540 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.950316e-01 | 0.530 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.950316e-01 | 0.530 |
| R-HSA-9638482 | Metal ion assimilation from the host | 2.981920e-01 | 0.526 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.013384e-01 | 0.521 |
| R-HSA-162906 | HIV Infection | 3.028678e-01 | 0.519 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.044709e-01 | 0.516 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.045178e-01 | 0.516 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.075896e-01 | 0.512 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.106945e-01 | 0.508 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.199270e-01 | 0.495 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.199270e-01 | 0.495 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 3.229773e-01 | 0.491 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.260141e-01 | 0.487 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.260141e-01 | 0.487 |
| R-HSA-9833482 | PKR-mediated signaling | 3.260141e-01 | 0.487 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.380276e-01 | 0.471 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.439550e-01 | 0.463 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.468990e-01 | 0.460 |
| R-HSA-9663891 | Selective autophagy | 3.527480e-01 | 0.453 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.556531e-01 | 0.449 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.699868e-01 | 0.432 |
| R-HSA-112316 | Neuronal System | 3.744019e-01 | 0.427 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.793383e-01 | 0.421 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.812270e-01 | 0.419 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.840060e-01 | 0.416 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.895271e-01 | 0.409 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.922693e-01 | 0.406 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.949994e-01 | 0.403 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.977174e-01 | 0.400 |
| R-HSA-9833110 | RSV-host interactions | 4.057994e-01 | 0.392 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.084695e-01 | 0.389 |
| R-HSA-69239 | Synthesis of DNA | 4.137744e-01 | 0.383 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.164092e-01 | 0.380 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.164092e-01 | 0.380 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.396029e-01 | 0.357 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.507609e-01 | 0.346 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.545579e-01 | 0.342 |
| R-HSA-3371556 | Cellular response to heat stress | 4.545579e-01 | 0.342 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.545579e-01 | 0.342 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.545579e-01 | 0.342 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.618872e-01 | 0.335 |
| R-HSA-9909396 | Circadian clock | 4.856235e-01 | 0.314 |
| R-HSA-109582 | Hemostasis | 4.879039e-01 | 0.312 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.993665e-01 | 0.302 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.016216e-01 | 0.300 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.061016e-01 | 0.296 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.061016e-01 | 0.296 |
| R-HSA-9664407 | Parasite infection | 5.061016e-01 | 0.296 |
| R-HSA-1632852 | Macroautophagy | 5.083267e-01 | 0.294 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.127473e-01 | 0.290 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.342692e-01 | 0.272 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.342692e-01 | 0.272 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.384597e-01 | 0.269 |
| R-HSA-913531 | Interferon Signaling | 5.420963e-01 | 0.266 |
| R-HSA-9612973 | Autophagy | 5.426130e-01 | 0.266 |
| R-HSA-162587 | HIV Life Cycle | 5.446758e-01 | 0.264 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.467295e-01 | 0.262 |
| R-HSA-877300 | Interferon gamma signaling | 5.487740e-01 | 0.261 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.508094e-01 | 0.259 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.514458e-01 | 0.258 |
| R-HSA-418594 | G alpha (i) signalling events | 5.736014e-01 | 0.241 |
| R-HSA-983712 | Ion channel transport | 6.078346e-01 | 0.216 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.166182e-01 | 0.210 |
| R-HSA-9640148 | Infection with Enterobacteria | 6.319424e-01 | 0.199 |
| R-HSA-72172 | mRNA Splicing | 6.352649e-01 | 0.197 |
| R-HSA-68882 | Mitotic Anaphase | 6.545875e-01 | 0.184 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.561514e-01 | 0.183 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.210172e-01 | 0.142 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.406200e-01 | 0.130 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.429728e-01 | 0.129 |
| R-HSA-9658195 | Leishmania infection | 7.429728e-01 | 0.129 |
| R-HSA-8953854 | Metabolism of RNA | 7.434258e-01 | 0.129 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.599605e-01 | 0.119 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.394929e-01 | 0.076 |
| R-HSA-6798695 | Neutrophil degranulation | 8.857772e-01 | 0.053 |
| R-HSA-382551 | Transport of small molecules | 9.902024e-01 | 0.004 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
DAPK1 |
0.692 | 0.276 | -3 | 0.714 |
GRK7 |
0.688 | 0.156 | 1 | 0.692 |
SKMLCK |
0.687 | 0.259 | -2 | 0.799 |
DAPK2 |
0.687 | 0.239 | -3 | 0.709 |
DAPK3 |
0.685 | 0.249 | -3 | 0.737 |
PASK |
0.684 | 0.208 | -3 | 0.720 |
CAMLCK |
0.683 | 0.205 | -2 | 0.774 |
CLK3 |
0.683 | 0.208 | 1 | 0.640 |
DRAK1 |
0.682 | 0.240 | 1 | 0.693 |
GRK1 |
0.681 | 0.151 | -2 | 0.671 |
AURA |
0.680 | 0.264 | -2 | 0.756 |
BMPR1B |
0.680 | 0.154 | 1 | 0.678 |
SMMLCK |
0.679 | 0.205 | -3 | 0.703 |
CLK2 |
0.678 | 0.239 | -3 | 0.719 |
COT |
0.678 | 0.142 | 2 | 0.661 |
CAMK1B |
0.678 | 0.164 | -3 | 0.732 |
GAK |
0.677 | 0.123 | 1 | 0.637 |
MOS |
0.677 | 0.093 | 1 | 0.604 |
CLK4 |
0.677 | 0.211 | -3 | 0.712 |
GRK2 |
0.677 | 0.112 | -2 | 0.599 |
GRK6 |
0.676 | 0.109 | 1 | 0.726 |
ACVR2B |
0.676 | 0.116 | -2 | 0.627 |
DMPK1 |
0.674 | 0.233 | -3 | 0.743 |
MYLK4 |
0.674 | 0.224 | -2 | 0.800 |
TAO3 |
0.674 | 0.110 | 1 | 0.659 |
CLK1 |
0.674 | 0.204 | -3 | 0.719 |
DLK |
0.674 | 0.073 | 1 | 0.711 |
NIK |
0.674 | 0.103 | -3 | 0.726 |
AKT2 |
0.673 | 0.190 | -3 | 0.661 |
LATS1 |
0.673 | 0.120 | -3 | 0.731 |
TGFBR1 |
0.673 | 0.075 | -2 | 0.615 |
MST3 |
0.673 | 0.104 | 2 | 0.594 |
PRPK |
0.673 | 0.013 | -1 | 0.739 |
BMPR2 |
0.672 | -0.032 | -2 | 0.664 |
ALK4 |
0.672 | 0.038 | -2 | 0.637 |
NLK |
0.671 | 0.030 | 1 | 0.678 |
GRK3 |
0.671 | 0.112 | -2 | 0.588 |
GSK3B |
0.671 | 0.083 | 4 | 0.379 |
MEKK3 |
0.671 | 0.037 | 1 | 0.674 |
PKN2 |
0.670 | 0.157 | -3 | 0.719 |
GSK3A |
0.670 | 0.092 | 4 | 0.378 |
ATR |
0.669 | 0.029 | 1 | 0.612 |
ICK |
0.669 | 0.071 | -3 | 0.694 |
ACVR2A |
0.669 | 0.073 | -2 | 0.612 |
ANKRD3 |
0.669 | -0.011 | 1 | 0.675 |
PAK1 |
0.668 | 0.201 | -2 | 0.769 |
RSK2 |
0.668 | 0.179 | -3 | 0.696 |
MEK1 |
0.668 | 0.002 | 2 | 0.637 |
PIM3 |
0.668 | 0.115 | -3 | 0.731 |
VRK2 |
0.668 | -0.079 | 1 | 0.663 |
BMPR1A |
0.668 | 0.108 | 1 | 0.650 |
RAF1 |
0.668 | 0.057 | 1 | 0.671 |
PLK1 |
0.668 | 0.038 | -2 | 0.611 |
GRK5 |
0.667 | 0.023 | -3 | 0.651 |
MSK1 |
0.667 | 0.213 | -3 | 0.648 |
P70S6KB |
0.667 | 0.146 | -3 | 0.708 |
PKACG |
0.667 | 0.208 | -2 | 0.790 |
RIPK3 |
0.667 | 0.052 | 3 | 0.522 |
HPK1 |
0.667 | 0.113 | 1 | 0.687 |
CDKL1 |
0.667 | 0.045 | -3 | 0.677 |
MEKK2 |
0.666 | -0.012 | 2 | 0.584 |
RSK4 |
0.666 | 0.183 | -3 | 0.700 |
BRAF |
0.666 | 0.020 | -4 | 0.628 |
GCK |
0.666 | 0.088 | 1 | 0.685 |
MLK4 |
0.666 | 0.040 | 2 | 0.519 |
SGK3 |
0.666 | 0.166 | -3 | 0.675 |
MLK1 |
0.665 | -0.010 | 2 | 0.589 |
PDK1 |
0.665 | 0.047 | 1 | 0.594 |
PKCD |
0.665 | 0.120 | 2 | 0.554 |
PKG2 |
0.665 | 0.226 | -2 | 0.775 |
JNK3 |
0.665 | 0.049 | 1 | 0.557 |
PKACB |
0.664 | 0.242 | -2 | 0.781 |
GRK4 |
0.664 | 0.050 | -2 | 0.678 |
PKR |
0.664 | -0.032 | 1 | 0.590 |
CAMK2G |
0.664 | 0.007 | 2 | 0.614 |
AURB |
0.663 | 0.220 | -2 | 0.765 |
NEK11 |
0.663 | 0.013 | 1 | 0.673 |
TAK1 |
0.663 | 0.051 | 1 | 0.642 |
MEK5 |
0.663 | -0.046 | 2 | 0.615 |
PKN3 |
0.663 | 0.066 | -3 | 0.704 |
DSTYK |
0.663 | 0.034 | 2 | 0.650 |
MAP3K15 |
0.663 | 0.024 | 1 | 0.649 |
PKCA |
0.663 | 0.113 | 2 | 0.506 |
SRPK3 |
0.662 | 0.072 | -3 | 0.657 |
ALPHAK3 |
0.662 | 0.083 | -1 | 0.677 |
YSK4 |
0.662 | -0.015 | 1 | 0.649 |
ALK2 |
0.662 | 0.020 | -2 | 0.623 |
TAO2 |
0.662 | 0.040 | 2 | 0.591 |
MST4 |
0.662 | 0.077 | 2 | 0.572 |
JNK2 |
0.662 | 0.054 | 1 | 0.553 |
PAK2 |
0.661 | 0.162 | -2 | 0.751 |
AKT1 |
0.661 | 0.189 | -3 | 0.672 |
MTOR |
0.661 | 0.039 | 1 | 0.638 |
EEF2K |
0.661 | -0.001 | 3 | 0.545 |
CDK1 |
0.660 | 0.058 | 1 | 0.567 |
RIPK1 |
0.660 | -0.005 | 1 | 0.596 |
PLK2 |
0.659 | 0.079 | -3 | 0.665 |
AURC |
0.659 | 0.236 | -2 | 0.775 |
TGFBR2 |
0.659 | 0.006 | -2 | 0.643 |
HIPK1 |
0.659 | 0.077 | 1 | 0.572 |
ZAK |
0.659 | -0.025 | 1 | 0.684 |
PAK3 |
0.659 | 0.166 | -2 | 0.752 |
WNK1 |
0.658 | 0.058 | -2 | 0.716 |
TTK |
0.658 | 0.031 | -2 | 0.650 |
JNK1 |
0.658 | 0.047 | 1 | 0.550 |
MINK |
0.658 | 0.006 | 1 | 0.654 |
SGK1 |
0.658 | 0.145 | -3 | 0.597 |
PKCH |
0.658 | 0.089 | 2 | 0.523 |
TTBK2 |
0.658 | -0.012 | 2 | 0.558 |
PIM1 |
0.658 | 0.092 | -3 | 0.710 |
ROCK2 |
0.658 | 0.156 | -3 | 0.709 |
TLK2 |
0.658 | -0.022 | 1 | 0.589 |
MLK3 |
0.658 | 0.000 | 2 | 0.519 |
MRCKB |
0.658 | 0.174 | -3 | 0.695 |
PKACA |
0.658 | 0.230 | -2 | 0.765 |
DYRK2 |
0.657 | 0.069 | 1 | 0.557 |
IKKB |
0.657 | 0.026 | -2 | 0.561 |
PKCG |
0.657 | 0.100 | 2 | 0.537 |
KHS2 |
0.657 | 0.065 | 1 | 0.671 |
CDK14 |
0.657 | 0.081 | 1 | 0.569 |
MST2 |
0.657 | -0.015 | 1 | 0.679 |
TNIK |
0.657 | 0.024 | 3 | 0.523 |
DCAMKL1 |
0.657 | 0.101 | -3 | 0.743 |
PKCE |
0.656 | 0.129 | 2 | 0.518 |
TBK1 |
0.656 | -0.019 | 1 | 0.638 |
DCAMKL2 |
0.656 | 0.095 | -3 | 0.758 |
MSK2 |
0.656 | 0.147 | -3 | 0.640 |
NEK8 |
0.656 | -0.040 | 2 | 0.610 |
VRK1 |
0.656 | -0.040 | 2 | 0.661 |
DYRK4 |
0.656 | 0.107 | 1 | 0.515 |
RSK3 |
0.656 | 0.131 | -3 | 0.693 |
OSR1 |
0.656 | 0.027 | 2 | 0.573 |
SRPK1 |
0.655 | 0.074 | -3 | 0.670 |
MAK |
0.655 | 0.082 | -2 | 0.591 |
PLK3 |
0.655 | 0.009 | 2 | 0.646 |
KHS1 |
0.654 | 0.045 | 1 | 0.647 |
CAMK4 |
0.654 | 0.135 | -3 | 0.730 |
P38A |
0.654 | 0.016 | 1 | 0.578 |
P90RSK |
0.654 | 0.102 | -3 | 0.683 |
DYRK3 |
0.654 | 0.127 | 1 | 0.561 |
MEKK6 |
0.654 | -0.018 | 1 | 0.640 |
PDHK4 |
0.654 | -0.124 | 1 | 0.667 |
MST1 |
0.654 | -0.019 | 1 | 0.663 |
MRCKA |
0.654 | 0.155 | -3 | 0.706 |
P38G |
0.654 | 0.031 | 1 | 0.510 |
MNK1 |
0.654 | 0.176 | -2 | 0.781 |
MEKK1 |
0.654 | -0.081 | 1 | 0.658 |
NUAK2 |
0.654 | 0.055 | -3 | 0.745 |
IKKE |
0.653 | -0.017 | 1 | 0.646 |
IKKA |
0.653 | 0.046 | -2 | 0.535 |
MASTL |
0.653 | -0.122 | -2 | 0.607 |
ERK5 |
0.653 | -0.052 | 1 | 0.619 |
CDC7 |
0.653 | -0.010 | 1 | 0.617 |
P38B |
0.652 | 0.021 | 1 | 0.558 |
PIM2 |
0.652 | 0.087 | -3 | 0.680 |
CAMK2A |
0.652 | 0.103 | 2 | 0.585 |
PRKX |
0.652 | 0.233 | -3 | 0.700 |
HGK |
0.652 | -0.020 | 3 | 0.545 |
CDK5 |
0.652 | 0.027 | 1 | 0.564 |
NDR1 |
0.652 | 0.094 | -3 | 0.731 |
CAMK2B |
0.651 | 0.071 | 2 | 0.592 |
MYO3A |
0.651 | 0.029 | 1 | 0.602 |
PRP4 |
0.651 | -0.026 | -3 | 0.503 |
ROCK1 |
0.651 | 0.158 | -3 | 0.696 |
CDK2 |
0.650 | 0.017 | 1 | 0.659 |
LRRK2 |
0.650 | -0.066 | 2 | 0.628 |
CK1A2 |
0.650 | 0.046 | -3 | 0.405 |
PLK4 |
0.649 | -0.010 | 2 | 0.572 |
PKCB |
0.649 | 0.056 | 2 | 0.501 |
HIPK3 |
0.649 | 0.061 | 1 | 0.570 |
CDKL5 |
0.649 | 0.015 | -3 | 0.656 |
HIPK2 |
0.649 | 0.076 | 1 | 0.488 |
YANK3 |
0.649 | 0.040 | 2 | 0.397 |
TLK1 |
0.649 | -0.064 | -2 | 0.667 |
NEK7 |
0.649 | -0.082 | -3 | 0.582 |
ASK1 |
0.648 | -0.020 | 1 | 0.646 |
DYRK1A |
0.648 | 0.052 | 1 | 0.578 |
MNK2 |
0.648 | 0.167 | -2 | 0.770 |
LOK |
0.648 | 0.015 | -2 | 0.647 |
HUNK |
0.648 | -0.057 | 2 | 0.652 |
CHAK2 |
0.648 | -0.082 | -1 | 0.652 |
CHK2 |
0.648 | 0.105 | -3 | 0.641 |
WNK3 |
0.648 | -0.066 | 1 | 0.612 |
BMPR2_TYR |
0.648 | 0.209 | -1 | 0.719 |
AKT3 |
0.647 | 0.156 | -3 | 0.609 |
HASPIN |
0.647 | 0.029 | -1 | 0.596 |
ULK2 |
0.647 | -0.096 | 2 | 0.594 |
MLK2 |
0.647 | -0.124 | 2 | 0.569 |
CDK17 |
0.647 | 0.040 | 1 | 0.506 |
PAK6 |
0.646 | 0.222 | -2 | 0.709 |
NEK5 |
0.646 | -0.124 | 1 | 0.601 |
PDHK1 |
0.646 | -0.148 | 1 | 0.677 |
SRPK2 |
0.646 | 0.075 | -3 | 0.626 |
SLK |
0.646 | 0.006 | -2 | 0.600 |
CAMK2D |
0.646 | 0.019 | -3 | 0.671 |
PKCZ |
0.646 | 0.028 | 2 | 0.555 |
CDK18 |
0.646 | 0.050 | 1 | 0.522 |
ERK2 |
0.645 | -0.016 | 1 | 0.566 |
IRE1 |
0.645 | -0.060 | 1 | 0.525 |
NDR2 |
0.645 | 0.077 | -3 | 0.732 |
WNK4 |
0.645 | -0.058 | -2 | 0.672 |
ATM |
0.645 | -0.026 | 1 | 0.549 |
TSSK2 |
0.645 | -0.002 | -5 | 0.611 |
CDK3 |
0.644 | 0.036 | 1 | 0.512 |
CDK10 |
0.644 | 0.074 | 1 | 0.547 |
PKCT |
0.644 | 0.082 | 2 | 0.520 |
YSK1 |
0.644 | -0.027 | 2 | 0.549 |
FYN |
0.644 | 0.151 | -1 | 0.723 |
ERK1 |
0.643 | -0.001 | 1 | 0.540 |
CHAK1 |
0.643 | -0.080 | 2 | 0.574 |
NEK9 |
0.643 | -0.145 | 2 | 0.581 |
PERK |
0.643 | -0.137 | -2 | 0.639 |
IRAK4 |
0.643 | -0.058 | 1 | 0.547 |
HRI |
0.643 | -0.131 | -2 | 0.649 |
PINK1 |
0.642 | -0.067 | 1 | 0.584 |
IRAK1 |
0.642 | -0.087 | -1 | 0.635 |
ITK |
0.642 | 0.156 | -1 | 0.680 |
CK1D |
0.642 | 0.019 | -3 | 0.396 |
BMX |
0.641 | 0.151 | -1 | 0.692 |
HIPK4 |
0.641 | 0.002 | 1 | 0.570 |
TXK |
0.641 | 0.154 | 1 | 0.705 |
TSSK1 |
0.641 | 0.018 | -3 | 0.726 |
MPSK1 |
0.640 | -0.068 | 1 | 0.534 |
DYRK1B |
0.640 | 0.046 | 1 | 0.538 |
AMPKA1 |
0.640 | -0.020 | -3 | 0.722 |
CAMK1G |
0.640 | 0.054 | -3 | 0.692 |
IRE2 |
0.639 | -0.070 | 2 | 0.559 |
CDK16 |
0.639 | 0.042 | 1 | 0.510 |
RIPK2 |
0.639 | -0.051 | 1 | 0.628 |
P70S6K |
0.639 | 0.070 | -3 | 0.631 |
NEK4 |
0.639 | -0.122 | 1 | 0.611 |
YES1 |
0.639 | 0.081 | -1 | 0.701 |
CDK6 |
0.639 | 0.019 | 1 | 0.534 |
PKCI |
0.639 | 0.061 | 2 | 0.536 |
TTBK1 |
0.638 | -0.038 | 2 | 0.531 |
NEK6 |
0.638 | -0.073 | -2 | 0.651 |
FGFR2 |
0.638 | 0.114 | 3 | 0.572 |
YANK2 |
0.638 | 0.020 | 2 | 0.406 |
CAMKK1 |
0.638 | -0.153 | -2 | 0.520 |
EPHA6 |
0.638 | 0.129 | -1 | 0.693 |
STK33 |
0.638 | -0.041 | 2 | 0.553 |
ULK1 |
0.638 | -0.105 | -3 | 0.560 |
TAO1 |
0.638 | -0.009 | 1 | 0.593 |
NEK2 |
0.638 | -0.088 | 2 | 0.562 |
MEK2 |
0.638 | -0.145 | 2 | 0.597 |
CRIK |
0.638 | 0.087 | -3 | 0.651 |
KDR |
0.638 | 0.102 | 3 | 0.540 |
GCN2 |
0.637 | -0.116 | 2 | 0.564 |
MYO3B |
0.637 | -0.024 | 2 | 0.554 |
PAK5 |
0.637 | 0.200 | -2 | 0.684 |
CK1E |
0.637 | 0.014 | -3 | 0.441 |
STLK3 |
0.637 | -0.056 | 1 | 0.655 |
MELK |
0.637 | 0.023 | -3 | 0.705 |
SNRK |
0.637 | 0.018 | 2 | 0.627 |
NEK1 |
0.636 | -0.128 | 1 | 0.596 |
MAP2K6_TYR |
0.636 | 0.117 | -1 | 0.705 |
CDK12 |
0.636 | 0.003 | 1 | 0.528 |
PRKD3 |
0.636 | 0.053 | -3 | 0.696 |
FGFR3 |
0.636 | 0.098 | 3 | 0.550 |
CAMK1D |
0.636 | 0.083 | -3 | 0.673 |
KIT |
0.635 | 0.090 | 3 | 0.519 |
SRC |
0.635 | 0.095 | -1 | 0.707 |
MET |
0.635 | 0.097 | 3 | 0.517 |
DNAPK |
0.635 | -0.034 | 1 | 0.525 |
PDHK1_TYR |
0.635 | 0.096 | -1 | 0.709 |
MAPKAPK3 |
0.635 | 0.027 | -3 | 0.668 |
CDK8 |
0.634 | -0.017 | 1 | 0.578 |
SYK |
0.634 | 0.150 | -1 | 0.664 |
SRMS |
0.634 | 0.111 | 1 | 0.709 |
PHKG2 |
0.634 | 0.110 | -3 | 0.750 |
FGR |
0.634 | 0.062 | 1 | 0.680 |
P38D |
0.634 | 0.012 | 1 | 0.461 |
PTK2 |
0.634 | 0.158 | -1 | 0.643 |
NIM1 |
0.634 | -0.060 | 3 | 0.483 |
PDHK3_TYR |
0.634 | 0.065 | 4 | 0.512 |
CSF1R |
0.634 | 0.056 | 3 | 0.509 |
PHKG1 |
0.634 | 0.016 | -3 | 0.720 |
INSRR |
0.633 | 0.057 | 3 | 0.518 |
LKB1 |
0.633 | -0.123 | -3 | 0.573 |
EPHB4 |
0.633 | 0.089 | -1 | 0.663 |
CDK13 |
0.633 | -0.013 | 1 | 0.538 |
PAK4 |
0.633 | 0.191 | -2 | 0.700 |
EGFR |
0.633 | 0.098 | 1 | 0.674 |
CDK4 |
0.633 | 0.016 | 1 | 0.521 |
PBK |
0.633 | -0.037 | 1 | 0.534 |
MOK |
0.632 | 0.028 | 1 | 0.542 |
PTK2B |
0.632 | 0.114 | -1 | 0.680 |
FAM20C |
0.632 | 0.029 | 2 | 0.511 |
SMG1 |
0.632 | -0.076 | 1 | 0.552 |
FLT3 |
0.632 | 0.060 | 3 | 0.538 |
KIS |
0.632 | 0.024 | 1 | 0.569 |
PRKD2 |
0.632 | 0.077 | -3 | 0.696 |
LCK |
0.632 | 0.078 | -1 | 0.719 |
MERTK |
0.632 | 0.078 | 3 | 0.510 |
BLK |
0.632 | 0.086 | -1 | 0.699 |
MAP2K4_TYR |
0.632 | 0.030 | -1 | 0.709 |
MARK4 |
0.631 | -0.092 | 4 | 0.427 |
MAPKAPK2 |
0.631 | 0.056 | -3 | 0.672 |
PKG1 |
0.631 | 0.184 | -2 | 0.740 |
TYRO3 |
0.631 | 0.027 | 3 | 0.521 |
BIKE |
0.630 | -0.033 | 1 | 0.527 |
FER |
0.630 | 0.049 | 1 | 0.683 |
LATS2 |
0.630 | 0.014 | -5 | 0.633 |
ERK7 |
0.630 | -0.035 | 2 | 0.365 |
BUB1 |
0.630 | 0.003 | -5 | 0.615 |
RET |
0.630 | 0.044 | 1 | 0.655 |
PINK1_TYR |
0.630 | 0.021 | 1 | 0.643 |
FGFR4 |
0.630 | 0.088 | -1 | 0.658 |
MST1R |
0.630 | 0.028 | 3 | 0.529 |
QIK |
0.630 | -0.060 | -3 | 0.690 |
MATK |
0.630 | 0.085 | -1 | 0.652 |
BRSK1 |
0.630 | 0.029 | -3 | 0.716 |
EPHA8 |
0.629 | 0.105 | -1 | 0.659 |
CK2A2 |
0.629 | 0.023 | 1 | 0.552 |
SSTK |
0.629 | -0.000 | 4 | 0.421 |
HCK |
0.629 | 0.033 | -1 | 0.710 |
AMPKA2 |
0.629 | -0.023 | -3 | 0.723 |
PDHK4_TYR |
0.629 | 0.064 | 2 | 0.675 |
CAMKK2 |
0.629 | -0.183 | -2 | 0.535 |
ERBB4 |
0.629 | 0.103 | 1 | 0.707 |
PKN1 |
0.629 | 0.065 | -3 | 0.650 |
MAP2K7_TYR |
0.629 | -0.027 | 2 | 0.660 |
MARK2 |
0.629 | -0.052 | 4 | 0.355 |
ABL2 |
0.629 | 0.040 | -1 | 0.693 |
FLT1 |
0.629 | 0.067 | -1 | 0.649 |
MARK3 |
0.628 | -0.018 | 4 | 0.375 |
FRK |
0.628 | 0.072 | -1 | 0.681 |
CDK7 |
0.628 | -0.016 | 1 | 0.555 |
ERBB2 |
0.628 | 0.045 | 1 | 0.694 |
PKMYT1_TYR |
0.628 | -0.043 | 3 | 0.543 |
ROS1 |
0.628 | 0.006 | 3 | 0.515 |
CAMK1A |
0.628 | 0.081 | -3 | 0.673 |
EPHB1 |
0.628 | 0.075 | 1 | 0.708 |
CK2A1 |
0.628 | 0.037 | 1 | 0.553 |
ABL1 |
0.627 | 0.030 | -1 | 0.689 |
ALK |
0.627 | 0.055 | 3 | 0.541 |
MARK1 |
0.627 | -0.031 | 4 | 0.383 |
WEE1_TYR |
0.627 | 0.055 | -1 | 0.683 |
PRKD1 |
0.627 | -0.011 | -3 | 0.665 |
QSK |
0.626 | -0.022 | 4 | 0.413 |
PDGFRB |
0.626 | 0.011 | 3 | 0.539 |
EPHB2 |
0.626 | 0.068 | -1 | 0.647 |
EPHA7 |
0.626 | 0.072 | 2 | 0.657 |
TEC |
0.626 | 0.048 | -1 | 0.639 |
CSK |
0.626 | 0.061 | 2 | 0.648 |
EPHA4 |
0.626 | 0.055 | 2 | 0.662 |
FGFR1 |
0.626 | 0.028 | 3 | 0.532 |
ZAP70 |
0.625 | 0.125 | -1 | 0.671 |
LTK |
0.625 | 0.047 | 3 | 0.547 |
CK1G1 |
0.625 | 0.000 | -3 | 0.478 |
NTRK1 |
0.624 | 0.019 | -1 | 0.671 |
TESK1_TYR |
0.624 | -0.044 | 3 | 0.543 |
MAPKAPK5 |
0.624 | -0.017 | -3 | 0.584 |
CDK19 |
0.624 | -0.020 | 1 | 0.552 |
NTRK3 |
0.624 | 0.044 | -1 | 0.664 |
FLT4 |
0.623 | 0.021 | 3 | 0.528 |
SIK |
0.623 | -0.007 | -3 | 0.705 |
BTK |
0.623 | -0.002 | -1 | 0.650 |
LYN |
0.623 | 0.022 | 3 | 0.496 |
JAK2 |
0.623 | -0.042 | 1 | 0.662 |
AXL |
0.623 | 0.012 | 3 | 0.503 |
EPHA2 |
0.623 | 0.096 | -1 | 0.644 |
JAK3 |
0.622 | 0.003 | 1 | 0.629 |
NUAK1 |
0.622 | -0.020 | -3 | 0.733 |
TEK |
0.622 | 0.001 | 3 | 0.508 |
CHK1 |
0.622 | -0.070 | -3 | 0.701 |
EPHA5 |
0.622 | 0.069 | 2 | 0.667 |
CDK9 |
0.621 | -0.033 | 1 | 0.546 |
DDR1 |
0.621 | -0.022 | 4 | 0.458 |
TNK2 |
0.621 | 0.015 | 3 | 0.513 |
BRSK2 |
0.621 | -0.021 | -3 | 0.704 |
CK1G2 |
0.621 | 0.042 | -3 | 0.409 |
TYK2 |
0.621 | -0.071 | 1 | 0.649 |
SBK |
0.621 | 0.057 | -3 | 0.591 |
FES |
0.621 | 0.087 | -1 | 0.682 |
IGF1R |
0.620 | 0.025 | 3 | 0.457 |
INSR |
0.620 | -0.023 | 3 | 0.472 |
NTRK2 |
0.620 | -0.018 | 3 | 0.523 |
DDR2 |
0.619 | 0.055 | 3 | 0.553 |
EPHA3 |
0.619 | 0.027 | 2 | 0.643 |
LIMK2_TYR |
0.619 | -0.012 | -3 | 0.674 |
EPHB3 |
0.618 | 0.010 | -1 | 0.648 |
EPHA1 |
0.618 | 0.028 | 3 | 0.518 |
BCKDK |
0.618 | -0.180 | -1 | 0.585 |
AAK1 |
0.615 | -0.019 | 1 | 0.443 |
LIMK1_TYR |
0.615 | -0.126 | 2 | 0.627 |
JAK1 |
0.615 | -0.023 | 1 | 0.628 |
CK1A |
0.613 | 0.035 | -3 | 0.345 |
PDGFRA |
0.612 | -0.079 | 3 | 0.546 |
NEK3 |
0.612 | -0.170 | 1 | 0.588 |
PTK6 |
0.612 | -0.063 | -1 | 0.658 |
TNK1 |
0.612 | -0.031 | 3 | 0.500 |
MUSK |
0.611 | 0.019 | 1 | 0.639 |
CK1G3 |
0.608 | -0.010 | -3 | 0.325 |
TNNI3K_TYR |
0.604 | -0.025 | 1 | 0.624 |
NEK10_TYR |
0.602 | -0.089 | 1 | 0.544 |