Motif 980 (n=85)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| K7ERQ8 | None | S124 | ochoa | PCAF N-terminal domain-containing protein | None |
| O00161 | SNAP23 | S161 | ochoa|psp | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O60907 | TBL1X | S223 | psp | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}. |
| O95155 | UBE4B | S118 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| P02686 | MBP | S19 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P02686 | MBP | S285 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P04075 | ALDOA | S39 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P06748 | NPM1 | S43 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P09972 | ALDOC | S39 | ochoa | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P0CG47 | UBB | T22 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | T22 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P0DMV8 | HSPA1A | T66 | psp | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11142 | HSPA8 | S153 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12814 | ACTN1 | S754 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P14317 | HCLS1 | S112 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P14598 | NCF1 | S283 | psp | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P17066 | HSPA6 | T68 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P20339 | RAB5A | S123 | ochoa|psp | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P21333 | FLNA | S377 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P27348 | YWHAQ | S37 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P31946 | YWHAB | S39 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S37 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P31948 | STIP1 | S481 | ochoa | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P35609 | ACTN2 | S761 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P36871 | PGM1 | S408 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P38646 | HSPA9 | S89 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P38646 | HSPA9 | S200 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P46013 | MKI67 | S707 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48741 | HSPA7 | T68 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P50552 | VASP | S46 | ochoa | Vasodilator-stimulated phosphoprotein (VASP) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| P51148 | RAB5C | S124 | ochoa | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P52788 | SMS | S104 | ochoa | Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase) | Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). {ECO:0000269|PubMed:18367445, ECO:0000269|PubMed:18550699, ECO:0000269|PubMed:23696453, ECO:0000269|PubMed:23897707}. |
| P61020 | RAB5B | S123 | ochoa|psp | Ras-related protein Rab-5B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P61981 | YWHAG | S38 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62979 | RPS27A | T22 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | T22 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P63104 | YWHAZ | S37 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P78371 | CCT2 | S470 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q08043 | ACTN3 | S768 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q13243 | SRSF5 | S153 | ochoa | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. |
| Q13485 | SMAD4 | S343 | psp | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) | In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:9389648}. |
| Q13546 | RIPK1 | S389 | ochoa|psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q14247 | CTTN | S113 | ochoa|psp | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S150 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S261 | ochoa|psp | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S298 | ochoa|psp | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14D04 | VEPH1 | S425 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15056 | EIF4H | S94 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15599 | NHERF2 | S303 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15654 | TRIP6 | S102 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q2WGJ9 | FER1L6 | S27 | ochoa | Fer-1-like protein 6 | None |
| Q32MZ4 | LRRFIP1 | S686 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q6UXT9 | ABHD15 | S429 | ochoa | Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) | May regulate adipocyte lipolysis and liver lipid accumulation. {ECO:0000250|UniProtKB:Q5F2F2}. |
| Q86U42 | PABPN1 | S197 | ochoa | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| Q86U86 | PBRM1 | S378 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8IYS0 | GRAMD1C | S531 | ochoa | Protein Aster-C (GRAM domain-containing protein 1C) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q8CI52}. |
| Q8TAA3 | PSMA8 | S209 | ochoa | Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. {ECO:0000250|UniProtKB:Q9CWH6}. |
| Q92945 | KHSRP | S99 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96HC4 | PDLIM5 | S214 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JM3 | CHAMP1 | S572 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96K58 | ZNF668 | S176 | ochoa | Zinc finger protein 668 | May be involved in transcriptional regulation. May play a role in DNA repair process. {ECO:0000269|PubMed:34313816}. |
| Q99575 | POP1 | S24 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q9BRU9 | UTP23 | S174 | ochoa | rRNA-processing protein UTP23 homolog | Involved in rRNA-processing and ribosome biogenesis. {ECO:0000250}. |
| Q9BY12 | SCAPER | S294 | ochoa | S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) | CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}. |
| Q9C0D5 | TANC1 | S280 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9NQ84 | GPRC5C | S335 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NVU0 | POLR3E | S161 | ochoa | DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P36121, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:35637192}. |
| Q9UBT2 | UBA2 | S229 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
| Q9UIF9 | BAZ2A | S1559 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKI8 | TLK1 | S134 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UNK0 | STX8 | S160 | ochoa | Syntaxin-8 | Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. |
| Q9Y4C1 | KDM3A | S445 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
| P11142 | HSPA8 | T66 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P31327 | CPS1 | S569 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P16070 | CD44 | S71 | Sugiyama | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| O43390 | HNRNPR | Y136 | Sugiyama | Heterogeneous nuclear ribonucleoprotein R (hnRNP R) | Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. |
| O60506 | SYNCRIP | Y133 | Sugiyama | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}. |
| P28074 | PSMB5 | S229 | Sugiyama | Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| Q8TDD1 | DDX54 | S587 | Sugiyama | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q04917 | YWHAH | S38 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| O95747 | OXSR1 | S498 | Sugiyama | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| Q9UHX1 | PUF60 | S461 | Sugiyama | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9BVC4 | MLST8 | S43 | Sugiyama | Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) | Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073, PubMed:28489822). mTORC1 is activated in response to growth factors or amino acids (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:24403073). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:24403073). Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity (PubMed:12718876). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity (PubMed:12718876). As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:35926713). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (PubMed:15467718, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15467718, PubMed:35926713). mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15467718). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:15467718). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (PubMed:15467718). Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR (PubMed:31085701). {ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:28489822, ECO:0000269|PubMed:31085701, ECO:0000269|PubMed:35926713}. |
| Q9NQR4 | NIT2 | S244 | Sugiyama | Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) | Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}. |
| Q9NUQ8 | ABCF3 | S186 | Sugiyama | ATP-binding cassette sub-family F member 3 | Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.185541e-14 | 13.378 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.834644e-12 | 11.165 |
| R-HSA-3371556 | Cellular response to heat stress | 4.720446e-12 | 11.326 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.074374e-11 | 10.969 |
| R-HSA-3371568 | Attenuation phase | 2.757594e-11 | 10.559 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.989309e-11 | 10.524 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 5.330136e-11 | 10.273 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.287318e-10 | 9.890 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.709090e-09 | 8.767 |
| R-HSA-69481 | G2/M Checkpoints | 2.138367e-09 | 8.670 |
| R-HSA-109581 | Apoptosis | 2.026808e-09 | 8.693 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 3.297302e-09 | 8.482 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 3.297302e-09 | 8.482 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.432138e-08 | 7.844 |
| R-HSA-3371511 | HSF1 activation | 1.432138e-08 | 7.844 |
| R-HSA-8953854 | Metabolism of RNA | 1.718543e-08 | 7.765 |
| R-HSA-5357801 | Programmed Cell Death | 2.335653e-08 | 7.632 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 2.675841e-08 | 7.573 |
| R-HSA-2262752 | Cellular responses to stress | 2.591181e-08 | 7.587 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 3.856616e-08 | 7.414 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 1.466619e-07 | 6.834 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.398882e-07 | 6.854 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.731611e-07 | 6.762 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.245410e-07 | 6.649 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.208507e-07 | 6.656 |
| R-HSA-9694493 | Maturation of protein E | 2.489849e-07 | 6.604 |
| R-HSA-9683683 | Maturation of protein E | 2.489849e-07 | 6.604 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 4.411825e-07 | 6.355 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 5.430752e-07 | 6.265 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.682968e-07 | 6.245 |
| R-HSA-8948747 | Regulation of PTEN localization | 6.019911e-07 | 6.220 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 6.549337e-07 | 6.184 |
| R-HSA-3322077 | Glycogen synthesis | 6.627179e-07 | 6.179 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 8.771013e-07 | 6.057 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 7.393400e-07 | 6.131 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 8.771013e-07 | 6.057 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 8.771013e-07 | 6.057 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 8.022698e-07 | 6.096 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.727578e-07 | 6.112 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 8.771013e-07 | 6.057 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 8.771013e-07 | 6.057 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 9.901859e-07 | 6.004 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 9.909848e-07 | 6.004 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.236213e-06 | 5.908 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.694460e-06 | 5.771 |
| R-HSA-5689877 | Josephin domain DUBs | 1.694460e-06 | 5.771 |
| R-HSA-9664873 | Pexophagy | 1.694460e-06 | 5.771 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.186945e-06 | 5.660 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.268088e-06 | 5.644 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.268088e-06 | 5.644 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 2.198662e-06 | 5.658 |
| R-HSA-9824446 | Viral Infection Pathways | 2.550398e-06 | 5.593 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.551554e-06 | 5.593 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.974426e-06 | 5.527 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.974426e-06 | 5.527 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.974426e-06 | 5.527 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.390229e-06 | 5.470 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 3.831851e-06 | 5.417 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 3.831851e-06 | 5.417 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 3.831851e-06 | 5.417 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 3.831851e-06 | 5.417 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 3.831851e-06 | 5.417 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 3.831851e-06 | 5.417 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 3.831851e-06 | 5.417 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.828951e-06 | 5.417 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.431513e-06 | 5.353 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5.038357e-06 | 5.298 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 4.859765e-06 | 5.313 |
| R-HSA-199991 | Membrane Trafficking | 4.952922e-06 | 5.305 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 6.078562e-06 | 5.216 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.708497e-06 | 5.243 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 6.078562e-06 | 5.216 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 6.078562e-06 | 5.216 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 6.446541e-06 | 5.191 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 6.078562e-06 | 5.216 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 7.509601e-06 | 5.124 |
| R-HSA-110312 | Translesion synthesis by REV1 | 7.509601e-06 | 5.124 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 7.257287e-06 | 5.139 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 7.257287e-06 | 5.139 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 7.509601e-06 | 5.124 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 7.509601e-06 | 5.124 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 7.509601e-06 | 5.124 |
| R-HSA-193639 | p75NTR signals via NF-kB | 7.509601e-06 | 5.124 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.906234e-06 | 5.161 |
| R-HSA-5656121 | Translesion synthesis by POLI | 9.175174e-06 | 5.037 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 8.145728e-06 | 5.089 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 8.145728e-06 | 5.089 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 9.117051e-06 | 5.040 |
| R-HSA-169911 | Regulation of Apoptosis | 8.145728e-06 | 5.089 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 9.117051e-06 | 5.040 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 9.175174e-06 | 5.037 |
| R-HSA-9708530 | Regulation of BACH1 activity | 9.175174e-06 | 5.037 |
| R-HSA-9706369 | Negative regulation of FLT3 | 9.175174e-06 | 5.037 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.017664e-05 | 4.992 |
| R-HSA-4641258 | Degradation of DVL | 1.017664e-05 | 4.992 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.017664e-05 | 4.992 |
| R-HSA-4641257 | Degradation of AXIN | 1.017664e-05 | 4.992 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.017664e-05 | 4.992 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.017664e-05 | 4.992 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.109849e-05 | 4.955 |
| R-HSA-6798695 | Neutrophil degranulation | 1.099271e-05 | 4.959 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.133007e-05 | 4.946 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.109849e-05 | 4.955 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.258313e-05 | 4.900 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.109849e-05 | 4.955 |
| R-HSA-69541 | Stabilization of p53 | 1.258313e-05 | 4.900 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.258313e-05 | 4.900 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.109849e-05 | 4.955 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.254900e-05 | 4.901 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.269946e-05 | 4.896 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.308446e-05 | 4.883 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.330362e-05 | 4.876 |
| R-HSA-3229121 | Glycogen storage diseases | 1.330362e-05 | 4.876 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.394178e-05 | 4.856 |
| R-HSA-8982491 | Glycogen metabolism | 1.394178e-05 | 4.856 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.523486e-05 | 4.817 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.541221e-05 | 4.812 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.541221e-05 | 4.812 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.545620e-05 | 4.811 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.545620e-05 | 4.811 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.581552e-05 | 4.801 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.700078e-05 | 4.770 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.700078e-05 | 4.770 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.700078e-05 | 4.770 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.700078e-05 | 4.770 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.700078e-05 | 4.770 |
| R-HSA-9679506 | SARS-CoV Infections | 1.720499e-05 | 4.764 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.865994e-05 | 4.729 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.865994e-05 | 4.729 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.055890e-05 | 4.687 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.254221e-05 | 4.647 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.186346e-05 | 4.660 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.055890e-05 | 4.687 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.865994e-05 | 4.729 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.055890e-05 | 4.687 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.914803e-05 | 4.718 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.871409e-05 | 4.728 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.395240e-05 | 4.621 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.467118e-05 | 4.608 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.467118e-05 | 4.608 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.467118e-05 | 4.608 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.467118e-05 | 4.608 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.467118e-05 | 4.608 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.945792e-05 | 4.531 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.695320e-05 | 4.569 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.695320e-05 | 4.569 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.545342e-05 | 4.594 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.939586e-05 | 4.532 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.299831e-05 | 4.482 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.545342e-05 | 4.594 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.945792e-05 | 4.531 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.390577e-05 | 4.470 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.945792e-05 | 4.531 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.945792e-05 | 4.531 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.545342e-05 | 4.594 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 2.545342e-05 | 4.594 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.390577e-05 | 4.470 |
| R-HSA-168249 | Innate Immune System | 3.254724e-05 | 4.487 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.945792e-05 | 4.531 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.545342e-05 | 4.594 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.545342e-05 | 4.594 |
| R-HSA-9766229 | Degradation of CDH1 | 3.479447e-05 | 4.458 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.479447e-05 | 4.458 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.479447e-05 | 4.458 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.479447e-05 | 4.458 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.093172e-05 | 4.388 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.093172e-05 | 4.388 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.093172e-05 | 4.388 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.151967e-05 | 4.382 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.425035e-05 | 4.354 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.429845e-05 | 4.354 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.429845e-05 | 4.354 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.429845e-05 | 4.354 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.787558e-05 | 4.320 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.787558e-05 | 4.320 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.787558e-05 | 4.320 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.167210e-05 | 4.287 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.569721e-05 | 4.254 |
| R-HSA-5689901 | Metalloprotease DUBs | 5.673134e-05 | 4.246 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 5.673134e-05 | 4.246 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 5.673134e-05 | 4.246 |
| R-HSA-1500931 | Cell-Cell communication | 5.803537e-05 | 4.236 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.996029e-05 | 4.222 |
| R-HSA-75893 | TNF signaling | 5.996029e-05 | 4.222 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.996029e-05 | 4.222 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 6.385209e-05 | 4.195 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 6.385209e-05 | 4.195 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.447096e-05 | 4.191 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.698473e-05 | 4.174 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.069395e-05 | 4.151 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 7.160307e-05 | 4.145 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 7.160307e-05 | 4.145 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.812428e-05 | 4.107 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.958727e-05 | 4.099 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.958727e-05 | 4.099 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.958727e-05 | 4.099 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.958727e-05 | 4.099 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.958727e-05 | 4.099 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 8.001752e-05 | 4.097 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 8.001752e-05 | 4.097 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 8.001752e-05 | 4.097 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 8.001752e-05 | 4.097 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 8.518808e-05 | 4.070 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 8.912923e-05 | 4.050 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 9.108737e-05 | 4.041 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.108737e-05 | 4.041 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 9.729589e-05 | 4.012 |
| R-HSA-162588 | Budding and maturation of HIV virion | 9.897253e-05 | 4.004 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 9.897253e-05 | 4.004 |
| R-HSA-182971 | EGFR downregulation | 9.897253e-05 | 4.004 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 9.897253e-05 | 4.004 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.463649e-04 | 3.835 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.332424e-04 | 3.875 |
| R-HSA-5218859 | Regulated Necrosis | 1.333669e-04 | 3.875 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.594501e-04 | 3.797 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.594501e-04 | 3.797 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.463649e-04 | 3.835 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.463649e-04 | 3.835 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.209936e-04 | 3.917 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.106846e-04 | 3.956 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.547685e-04 | 3.810 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 1.463649e-04 | 3.835 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.503577e-04 | 3.823 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.503577e-04 | 3.823 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.503577e-04 | 3.823 |
| R-HSA-202403 | TCR signaling | 1.368179e-04 | 3.864 |
| R-HSA-1980145 | Signaling by NOTCH2 | 1.463649e-04 | 3.835 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.463649e-04 | 3.835 |
| R-HSA-5205647 | Mitophagy | 1.463649e-04 | 3.835 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.603977e-04 | 3.795 |
| R-HSA-168256 | Immune System | 1.687139e-04 | 3.773 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.689569e-04 | 3.772 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.753777e-04 | 3.756 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.788909e-04 | 3.747 |
| R-HSA-5689603 | UCH proteinases | 2.113840e-04 | 3.675 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.113840e-04 | 3.675 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.172054e-04 | 3.663 |
| R-HSA-9648002 | RAS processing | 2.263773e-04 | 3.645 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.263773e-04 | 3.645 |
| R-HSA-5619084 | ABC transporter disorders | 2.354205e-04 | 3.628 |
| R-HSA-4086400 | PCP/CE pathway | 2.354205e-04 | 3.628 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.355474e-04 | 3.628 |
| R-HSA-9646399 | Aggrephagy | 2.455240e-04 | 3.610 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.455240e-04 | 3.610 |
| R-HSA-913531 | Interferon Signaling | 2.572929e-04 | 3.590 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.584385e-04 | 3.588 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.642597e-04 | 3.578 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.658085e-04 | 3.575 |
| R-HSA-9607240 | FLT3 Signaling | 2.658085e-04 | 3.575 |
| R-HSA-9683701 | Translation of Structural Proteins | 2.872698e-04 | 3.542 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.046166e-04 | 3.516 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.201292e-04 | 3.495 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.201292e-04 | 3.495 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.338804e-04 | 3.476 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.362333e-04 | 3.473 |
| R-HSA-69236 | G1 Phase | 3.591090e-04 | 3.445 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.591090e-04 | 3.445 |
| R-HSA-9909396 | Circadian clock | 3.822347e-04 | 3.418 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.856733e-04 | 3.414 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.856733e-04 | 3.414 |
| R-HSA-9663891 | Selective autophagy | 4.068614e-04 | 3.391 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.136133e-04 | 3.383 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.136133e-04 | 3.383 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.429698e-04 | 3.354 |
| R-HSA-202424 | Downstream TCR signaling | 4.461142e-04 | 3.351 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.868127e-04 | 3.313 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.868127e-04 | 3.313 |
| R-HSA-6807070 | PTEN Regulation | 5.034098e-04 | 3.298 |
| R-HSA-73893 | DNA Damage Bypass | 5.060943e-04 | 3.296 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.060943e-04 | 3.296 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.331184e-04 | 3.273 |
| R-HSA-1632852 | Macroautophagy | 5.379250e-04 | 3.269 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.580843e-04 | 3.253 |
| R-HSA-373753 | Nephrin family interactions | 5.727572e-04 | 3.242 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.811245e-04 | 3.236 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.811245e-04 | 3.236 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.063103e-04 | 3.217 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 6.124246e-04 | 3.213 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.124246e-04 | 3.213 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.323066e-04 | 3.199 |
| R-HSA-446728 | Cell junction organization | 6.450584e-04 | 3.190 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.591299e-04 | 3.181 |
| R-HSA-1640170 | Cell Cycle | 7.182330e-04 | 3.144 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.337172e-04 | 3.134 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.447299e-04 | 3.128 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.447299e-04 | 3.128 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.750298e-04 | 3.111 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.776665e-04 | 3.109 |
| R-HSA-177929 | Signaling by EGFR | 7.776665e-04 | 3.109 |
| R-HSA-5654736 | Signaling by FGFR1 | 7.776665e-04 | 3.109 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.854486e-04 | 3.105 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.145224e-04 | 3.089 |
| R-HSA-6782135 | Dual incision in TC-NER | 8.710925e-04 | 3.060 |
| R-HSA-9612973 | Autophagy | 8.849934e-04 | 3.053 |
| R-HSA-9033241 | Peroxisomal protein import | 9.206526e-04 | 3.036 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.206526e-04 | 3.036 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.398547e-04 | 3.027 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 9.405528e-04 | 3.027 |
| R-HSA-5663205 | Infectious disease | 9.535749e-04 | 3.021 |
| R-HSA-1227986 | Signaling by ERBB2 | 9.721665e-04 | 3.012 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.013633e-03 | 2.994 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.013633e-03 | 2.994 |
| R-HSA-69239 | Synthesis of DNA | 1.013633e-03 | 2.994 |
| R-HSA-450294 | MAP kinase activation | 1.025676e-03 | 2.989 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.051716e-03 | 2.978 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.090851e-03 | 2.962 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.113068e-03 | 2.953 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.131058e-03 | 2.947 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.131058e-03 | 2.947 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.138848e-03 | 2.944 |
| R-HSA-8848021 | Signaling by PTK6 | 1.138848e-03 | 2.944 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.198594e-03 | 2.921 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.269974e-03 | 2.896 |
| R-HSA-157118 | Signaling by NOTCH | 1.388832e-03 | 2.857 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.390974e-03 | 2.857 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.390974e-03 | 2.857 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.420894e-03 | 2.847 |
| R-HSA-448424 | Interleukin-17 signaling | 1.603937e-03 | 2.795 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.679692e-03 | 2.775 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 1.757609e-03 | 2.755 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 1.759487e-03 | 2.755 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.759487e-03 | 2.755 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.838600e-03 | 2.736 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 1.838600e-03 | 2.736 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.880929e-03 | 2.726 |
| R-HSA-8852135 | Protein ubiquitination | 2.007645e-03 | 2.697 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.007645e-03 | 2.697 |
| R-HSA-5688426 | Deubiquitination | 1.905021e-03 | 2.720 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.902465e-03 | 2.537 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 2.722237e-03 | 2.565 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.392424e-03 | 2.621 |
| R-HSA-69275 | G2/M Transition | 2.024040e-03 | 2.694 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.123929e-03 | 2.673 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.803691e-03 | 2.552 |
| R-HSA-977225 | Amyloid fiber formation | 2.578846e-03 | 2.589 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.944096e-03 | 2.711 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.463266e-03 | 2.608 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.476737e-03 | 2.606 |
| R-HSA-70268 | Pyruvate metabolism | 3.375772e-03 | 2.472 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.007645e-03 | 2.697 |
| R-HSA-6806834 | Signaling by MET | 2.476737e-03 | 2.606 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.578846e-03 | 2.589 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.784798e-03 | 2.422 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.683810e-03 | 2.571 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.009674e-03 | 2.521 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.921835e-03 | 2.716 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.252849e-03 | 2.488 |
| R-HSA-69206 | G1/S Transition | 2.058787e-03 | 2.686 |
| R-HSA-917937 | Iron uptake and transport | 2.007645e-03 | 2.697 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.187152e-03 | 2.660 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 3.831260e-03 | 2.417 |
| R-HSA-68882 | Mitotic Anaphase | 4.030811e-03 | 2.395 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.033674e-03 | 2.394 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.113649e-03 | 2.386 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.180312e-03 | 2.379 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 4.180312e-03 | 2.379 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.243635e-03 | 2.372 |
| R-HSA-69242 | S Phase | 4.243635e-03 | 2.372 |
| R-HSA-8854214 | TBC/RABGAPs | 4.318381e-03 | 2.365 |
| R-HSA-9907900 | Proteasome assembly | 4.556649e-03 | 2.341 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.573062e-03 | 2.340 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.686810e-03 | 2.329 |
| R-HSA-9609507 | Protein localization | 4.802560e-03 | 2.319 |
| R-HSA-69306 | DNA Replication | 4.802560e-03 | 2.319 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.917074e-03 | 2.308 |
| R-HSA-73887 | Death Receptor Signaling | 4.920330e-03 | 2.308 |
| R-HSA-162906 | HIV Infection | 5.012986e-03 | 2.300 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.169233e-03 | 2.287 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.271947e-03 | 2.278 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.271947e-03 | 2.278 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.271947e-03 | 2.278 |
| R-HSA-190236 | Signaling by FGFR | 5.271947e-03 | 2.278 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.411991e-03 | 2.267 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.442016e-03 | 2.264 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.670433e-03 | 2.246 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.670433e-03 | 2.246 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.974162e-03 | 2.224 |
| R-HSA-74160 | Gene expression (Transcription) | 6.206805e-03 | 2.207 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.347548e-03 | 2.197 |
| R-HSA-9833110 | RSV-host interactions | 6.539926e-03 | 2.184 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.736138e-03 | 2.172 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 7.317266e-03 | 2.136 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.348096e-03 | 2.134 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.348096e-03 | 2.134 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.348096e-03 | 2.134 |
| R-HSA-72649 | Translation initiation complex formation | 7.380612e-03 | 2.132 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.406998e-03 | 2.130 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.559961e-03 | 2.121 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.728773e-03 | 2.112 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.728773e-03 | 2.112 |
| R-HSA-449147 | Signaling by Interleukins | 7.996060e-03 | 2.097 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 8.034281e-03 | 2.095 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 8.044895e-03 | 2.094 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 8.389825e-03 | 2.076 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.447629e-03 | 2.073 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.679748e-03 | 2.061 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 8.743345e-03 | 2.058 |
| R-HSA-168255 | Influenza Infection | 8.752412e-03 | 2.058 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 9.156433e-03 | 2.038 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.401056e-03 | 2.027 |
| R-HSA-8873719 | RAB geranylgeranylation | 9.476330e-03 | 2.023 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 9.649903e-03 | 2.015 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 9.649903e-03 | 2.015 |
| R-HSA-212436 | Generic Transcription Pathway | 9.735295e-03 | 2.012 |
| R-HSA-5693538 | Homology Directed Repair | 1.016038e-02 | 1.993 |
| R-HSA-392517 | Rap1 signalling | 1.036561e-02 | 1.984 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.042206e-02 | 1.982 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.042206e-02 | 1.982 |
| R-HSA-983712 | Ion channel transport | 1.066113e-02 | 1.972 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 1.095038e-02 | 1.961 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.107449e-02 | 1.956 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.123321e-02 | 1.949 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.123321e-02 | 1.949 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.215557e-02 | 1.915 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.275991e-02 | 1.894 |
| R-HSA-114608 | Platelet degranulation | 1.297522e-02 | 1.887 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.378665e-02 | 1.861 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 1.387988e-02 | 1.858 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.387988e-02 | 1.858 |
| R-HSA-68886 | M Phase | 1.442447e-02 | 1.841 |
| R-HSA-9675108 | Nervous system development | 1.454941e-02 | 1.837 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.460279e-02 | 1.836 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.461630e-02 | 1.835 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.521505e-02 | 1.818 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.534346e-02 | 1.814 |
| R-HSA-195721 | Signaling by WNT | 1.600009e-02 | 1.796 |
| R-HSA-418990 | Adherens junctions interactions | 1.805511e-02 | 1.743 |
| R-HSA-9833482 | PKR-mediated signaling | 1.876568e-02 | 1.727 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 1.882499e-02 | 1.725 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 1.882499e-02 | 1.725 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 1.882499e-02 | 1.725 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 1.882499e-02 | 1.725 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 1.882499e-02 | 1.725 |
| R-HSA-8951664 | Neddylation | 1.894254e-02 | 1.723 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.920296e-02 | 1.717 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.920296e-02 | 1.717 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.107706e-02 | 1.676 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.226312e-02 | 1.652 |
| R-HSA-162582 | Signal Transduction | 2.280674e-02 | 1.642 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.378387e-02 | 1.624 |
| R-HSA-156902 | Peptide chain elongation | 2.413619e-02 | 1.617 |
| R-HSA-72766 | Translation | 2.462220e-02 | 1.609 |
| R-HSA-162587 | HIV Life Cycle | 2.560049e-02 | 1.592 |
| R-HSA-9711097 | Cellular response to starvation | 2.606738e-02 | 1.584 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.609215e-02 | 1.583 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.676253e-02 | 1.572 |
| R-HSA-390522 | Striated Muscle Contraction | 2.697529e-02 | 1.569 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.744211e-02 | 1.562 |
| R-HSA-422475 | Axon guidance | 2.764099e-02 | 1.558 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.785379e-02 | 1.555 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.797104e-02 | 1.553 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.822611e-02 | 1.549 |
| R-HSA-421270 | Cell-cell junction organization | 2.942576e-02 | 1.531 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.025215e-02 | 1.519 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.025215e-02 | 1.519 |
| R-HSA-1643685 | Disease | 3.125199e-02 | 1.505 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.474106e-02 | 1.459 |
| R-HSA-192823 | Viral mRNA Translation | 3.630992e-02 | 1.440 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.710786e-02 | 1.431 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 3.729902e-02 | 1.428 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 3.729902e-02 | 1.428 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 3.729902e-02 | 1.428 |
| R-HSA-1280218 | Adaptive Immune System | 3.762629e-02 | 1.425 |
| R-HSA-2559583 | Cellular Senescence | 3.823314e-02 | 1.418 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.955026e-02 | 1.403 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.038929e-02 | 1.394 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 4.047595e-02 | 1.393 |
| R-HSA-165159 | MTOR signalling | 4.047595e-02 | 1.393 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.200054e-02 | 1.377 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.338016e-02 | 1.363 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.351404e-02 | 1.361 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.469103e-02 | 1.350 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.469103e-02 | 1.350 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.645515e-02 | 1.333 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.699361e-02 | 1.328 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.849733e-02 | 1.314 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 4.942326e-02 | 1.306 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 4.942326e-02 | 1.306 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 4.942326e-02 | 1.306 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 4.942326e-02 | 1.306 |
| R-HSA-70263 | Gluconeogenesis | 4.955899e-02 | 1.305 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.108071e-02 | 1.292 |
| R-HSA-72172 | mRNA Splicing | 5.459782e-02 | 1.263 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 5.542855e-02 | 1.256 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 5.542855e-02 | 1.256 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 5.542855e-02 | 1.256 |
| R-HSA-72187 | mRNA 3'-end processing | 5.598347e-02 | 1.252 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.763309e-02 | 1.239 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.929957e-02 | 1.227 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.128750e-02 | 1.213 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 6.139628e-02 | 1.212 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 6.139628e-02 | 1.212 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 6.139628e-02 | 1.212 |
| R-HSA-447041 | CHL1 interactions | 6.139628e-02 | 1.212 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.612849e-02 | 1.180 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 6.732667e-02 | 1.172 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 6.732667e-02 | 1.172 |
| R-HSA-3371378 | Regulation by c-FLIP | 6.732667e-02 | 1.172 |
| R-HSA-69416 | Dimerization of procaspase-8 | 6.732667e-02 | 1.172 |
| R-HSA-1266738 | Developmental Biology | 6.918294e-02 | 1.160 |
| R-HSA-351202 | Metabolism of polyamines | 6.963704e-02 | 1.157 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.141392e-02 | 1.146 |
| R-HSA-9613354 | Lipophagy | 7.321995e-02 | 1.135 |
| R-HSA-5218900 | CASP8 activity is inhibited | 7.321995e-02 | 1.135 |
| R-HSA-9700645 | ALK mutants bind TKIs | 7.321995e-02 | 1.135 |
| R-HSA-170984 | ARMS-mediated activation | 7.321995e-02 | 1.135 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 7.321995e-02 | 1.135 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 7.866625e-02 | 1.104 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 7.907636e-02 | 1.102 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 7.907636e-02 | 1.102 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 7.907636e-02 | 1.102 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.963721e-02 | 1.099 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.994203e-02 | 1.097 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 8.489613e-02 | 1.071 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 9.067947e-02 | 1.042 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 9.187758e-02 | 1.037 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 9.642662e-02 | 1.016 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 9.642662e-02 | 1.016 |
| R-HSA-9697154 | Disorders of Nervous System Development | 9.642662e-02 | 1.016 |
| R-HSA-9005895 | Pervasive developmental disorders | 9.642662e-02 | 1.016 |
| R-HSA-9842663 | Signaling by LTK | 9.642662e-02 | 1.016 |
| R-HSA-8983711 | OAS antiviral response | 9.642662e-02 | 1.016 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.775848e-02 | 1.010 |
| R-HSA-9020591 | Interleukin-12 signaling | 9.969803e-02 | 1.001 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.016817e-01 | 0.993 |
| R-HSA-170968 | Frs2-mediated activation | 1.021378e-01 | 0.991 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.078132e-01 | 0.967 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.078132e-01 | 0.967 |
| R-HSA-597592 | Post-translational protein modification | 1.089692e-01 | 0.963 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.094319e-01 | 0.961 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 1.134531e-01 | 0.945 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.134531e-01 | 0.945 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.134531e-01 | 0.945 |
| R-HSA-1502540 | Signaling by Activin | 1.134531e-01 | 0.945 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.134531e-01 | 0.945 |
| R-HSA-8876725 | Protein methylation | 1.134531e-01 | 0.945 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.179287e-01 | 0.928 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.188673e-01 | 0.925 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.190577e-01 | 0.924 |
| R-HSA-169893 | Prolonged ERK activation events | 1.190577e-01 | 0.924 |
| R-HSA-5635838 | Activation of SMO | 1.190577e-01 | 0.924 |
| R-HSA-9824439 | Bacterial Infection Pathways | 1.204759e-01 | 0.919 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.241809e-01 | 0.906 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.246273e-01 | 0.904 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.246273e-01 | 0.904 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.246273e-01 | 0.904 |
| R-HSA-70370 | Galactose catabolism | 1.246273e-01 | 0.904 |
| R-HSA-2028269 | Signaling by Hippo | 1.301619e-01 | 0.886 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.356619e-01 | 0.868 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.356619e-01 | 0.868 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.356619e-01 | 0.868 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.411275e-01 | 0.850 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.444309e-01 | 0.840 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.465588e-01 | 0.834 |
| R-HSA-1181150 | Signaling by NODAL | 1.465588e-01 | 0.834 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.465588e-01 | 0.834 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.519561e-01 | 0.818 |
| R-HSA-5668914 | Diseases of metabolism | 1.556262e-01 | 0.808 |
| R-HSA-70171 | Glycolysis | 1.565229e-01 | 0.805 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.573196e-01 | 0.803 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.573196e-01 | 0.803 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.573196e-01 | 0.803 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 1.573196e-01 | 0.803 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.573196e-01 | 0.803 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.626496e-01 | 0.789 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.626496e-01 | 0.789 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.626496e-01 | 0.789 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.626496e-01 | 0.789 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.679461e-01 | 0.775 |
| R-HSA-3000170 | Syndecan interactions | 1.679461e-01 | 0.775 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.679461e-01 | 0.775 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.698465e-01 | 0.770 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.732095e-01 | 0.761 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.732095e-01 | 0.761 |
| R-HSA-9865881 | Complex III assembly | 1.732095e-01 | 0.761 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 1.732095e-01 | 0.761 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.766234e-01 | 0.753 |
| R-HSA-9620244 | Long-term potentiation | 1.784399e-01 | 0.749 |
| R-HSA-2160916 | Hyaluronan degradation | 1.784399e-01 | 0.749 |
| R-HSA-9839394 | TGFBR3 expression | 1.784399e-01 | 0.749 |
| R-HSA-3214842 | HDMs demethylate histones | 1.784399e-01 | 0.749 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 1.784399e-01 | 0.749 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.784399e-01 | 0.749 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.784399e-01 | 0.749 |
| R-HSA-3295583 | TRP channels | 1.836375e-01 | 0.736 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.836375e-01 | 0.736 |
| R-HSA-70635 | Urea cycle | 1.836375e-01 | 0.736 |
| R-HSA-8949613 | Cristae formation | 1.888026e-01 | 0.724 |
| R-HSA-201451 | Signaling by BMP | 1.888026e-01 | 0.724 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.888026e-01 | 0.724 |
| R-HSA-392499 | Metabolism of proteins | 1.924906e-01 | 0.716 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 1.939353e-01 | 0.712 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.971043e-01 | 0.705 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.016968e-01 | 0.695 |
| R-HSA-70326 | Glucose metabolism | 2.016968e-01 | 0.695 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.041044e-01 | 0.690 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.041044e-01 | 0.690 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.041044e-01 | 0.690 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.041044e-01 | 0.690 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.091413e-01 | 0.680 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.141465e-01 | 0.669 |
| R-HSA-72312 | rRNA processing | 2.148342e-01 | 0.668 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.181270e-01 | 0.661 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.191204e-01 | 0.659 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.191204e-01 | 0.659 |
| R-HSA-9930044 | Nuclear RNA decay | 2.191204e-01 | 0.659 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.191204e-01 | 0.659 |
| R-HSA-9733709 | Cardiogenesis | 2.191204e-01 | 0.659 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.191204e-01 | 0.659 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 2.191204e-01 | 0.659 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 2.192459e-01 | 0.659 |
| R-HSA-73894 | DNA Repair | 2.212392e-01 | 0.655 |
| R-HSA-194138 | Signaling by VEGF | 2.225045e-01 | 0.653 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.240632e-01 | 0.650 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.240632e-01 | 0.650 |
| R-HSA-5673000 | RAF activation | 2.289749e-01 | 0.640 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.289749e-01 | 0.640 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.289749e-01 | 0.640 |
| R-HSA-2142845 | Hyaluronan metabolism | 2.289749e-01 | 0.640 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.289749e-01 | 0.640 |
| R-HSA-187687 | Signalling to ERKs | 2.338558e-01 | 0.631 |
| R-HSA-381042 | PERK regulates gene expression | 2.338558e-01 | 0.631 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.387062e-01 | 0.622 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.387062e-01 | 0.622 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.387062e-01 | 0.622 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.387062e-01 | 0.622 |
| R-HSA-9843745 | Adipogenesis | 2.388074e-01 | 0.622 |
| R-HSA-4839726 | Chromatin organization | 2.431393e-01 | 0.614 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.435261e-01 | 0.613 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.483159e-01 | 0.605 |
| R-HSA-109582 | Hemostasis | 2.489186e-01 | 0.604 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.530756e-01 | 0.597 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.530756e-01 | 0.597 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.530756e-01 | 0.597 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.530756e-01 | 0.597 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.578054e-01 | 0.589 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 2.578054e-01 | 0.589 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 2.578054e-01 | 0.589 |
| R-HSA-202433 | Generation of second messenger molecules | 2.578054e-01 | 0.589 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.625056e-01 | 0.581 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.671763e-01 | 0.573 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.671763e-01 | 0.573 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.671763e-01 | 0.573 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.671763e-01 | 0.573 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.671763e-01 | 0.573 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.810134e-01 | 0.551 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.810134e-01 | 0.551 |
| R-HSA-774815 | Nucleosome assembly | 2.855680e-01 | 0.544 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.855680e-01 | 0.544 |
| R-HSA-9824272 | Somitogenesis | 2.855680e-01 | 0.544 |
| R-HSA-9758941 | Gastrulation | 2.856065e-01 | 0.544 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.900941e-01 | 0.537 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.900941e-01 | 0.537 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.900941e-01 | 0.537 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.900941e-01 | 0.537 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.900941e-01 | 0.537 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.900941e-01 | 0.537 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.990612e-01 | 0.524 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.990612e-01 | 0.524 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.087895e-01 | 0.510 |
| R-HSA-877300 | Interferon gamma signaling | 3.089518e-01 | 0.510 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.166603e-01 | 0.499 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.209913e-01 | 0.494 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.295718e-01 | 0.482 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.338218e-01 | 0.476 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.505563e-01 | 0.455 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.546745e-01 | 0.450 |
| R-HSA-1268020 | Mitochondrial protein import | 3.587669e-01 | 0.445 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.587669e-01 | 0.445 |
| R-HSA-9707616 | Heme signaling | 3.587669e-01 | 0.445 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.587669e-01 | 0.445 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.628335e-01 | 0.440 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.628335e-01 | 0.440 |
| R-HSA-6799198 | Complex I biogenesis | 3.628335e-01 | 0.440 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.628335e-01 | 0.440 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.708903e-01 | 0.431 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.748808e-01 | 0.426 |
| R-HSA-5617833 | Cilium Assembly | 3.823475e-01 | 0.418 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.868377e-01 | 0.412 |
| R-HSA-68877 | Mitotic Prometaphase | 3.890776e-01 | 0.410 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 3.944603e-01 | 0.404 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.944603e-01 | 0.404 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.021210e-01 | 0.396 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.021210e-01 | 0.396 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.059153e-01 | 0.392 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 4.059153e-01 | 0.392 |
| R-HSA-380287 | Centrosome maturation | 4.096857e-01 | 0.388 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.096857e-01 | 0.388 |
| R-HSA-216083 | Integrin cell surface interactions | 4.208554e-01 | 0.376 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.245319e-01 | 0.372 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.281853e-01 | 0.368 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.281853e-01 | 0.368 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.318158e-01 | 0.365 |
| R-HSA-397014 | Muscle contraction | 4.330793e-01 | 0.363 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.354234e-01 | 0.361 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.390083e-01 | 0.358 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.461107e-01 | 0.351 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.496284e-01 | 0.347 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.496284e-01 | 0.347 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.565977e-01 | 0.340 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.565977e-01 | 0.340 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.600494e-01 | 0.337 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.600494e-01 | 0.337 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.668880e-01 | 0.331 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.668880e-01 | 0.331 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.702750e-01 | 0.328 |
| R-HSA-391251 | Protein folding | 4.769853e-01 | 0.321 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.836114e-01 | 0.316 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.933950e-01 | 0.307 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.061548e-01 | 0.296 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.124149e-01 | 0.290 |
| R-HSA-1483255 | PI Metabolism | 5.124149e-01 | 0.290 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.185964e-01 | 0.285 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.366790e-01 | 0.270 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.370512e-01 | 0.270 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.512328e-01 | 0.259 |
| R-HSA-373760 | L1CAM interactions | 5.625491e-01 | 0.250 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.681009e-01 | 0.246 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.762980e-01 | 0.239 |
| R-HSA-73886 | Chromosome Maintenance | 5.762980e-01 | 0.239 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.816769e-01 | 0.235 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.896187e-01 | 0.229 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.896187e-01 | 0.229 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.896187e-01 | 0.229 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.974113e-01 | 0.224 |
| R-HSA-112316 | Neuronal System | 6.019504e-01 | 0.220 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.100745e-01 | 0.215 |
| R-HSA-382551 | Transport of small molecules | 6.148482e-01 | 0.211 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.295202e-01 | 0.201 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.418323e-01 | 0.193 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.418323e-01 | 0.193 |
| R-HSA-166520 | Signaling by NTRKs | 6.524818e-01 | 0.185 |
| R-HSA-1474244 | Extracellular matrix organization | 6.543190e-01 | 0.184 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.569021e-01 | 0.182 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.655764e-01 | 0.177 |
| R-HSA-1989781 | PPARA activates gene expression | 6.677108e-01 | 0.175 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.719392e-01 | 0.173 |
| R-HSA-72306 | tRNA processing | 7.000829e-01 | 0.155 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.008538e-01 | 0.154 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.095435e-01 | 0.149 |
| R-HSA-611105 | Respiratory electron transport | 7.150774e-01 | 0.146 |
| R-HSA-3781865 | Diseases of glycosylation | 7.258339e-01 | 0.139 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 7.412190e-01 | 0.130 |
| R-HSA-9609690 | HCMV Early Events | 7.461550e-01 | 0.127 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.724144e-01 | 0.112 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.062188e-01 | 0.094 |
| R-HSA-9609646 | HCMV Infection | 8.217807e-01 | 0.085 |
| R-HSA-1483257 | Phospholipid metabolism | 8.666868e-01 | 0.062 |
| R-HSA-8957322 | Metabolism of steroids | 8.894828e-01 | 0.051 |
| R-HSA-1430728 | Metabolism | 9.888709e-01 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 9.994945e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
NUAK2 |
0.806 | 0.168 | -3 | 0.847 |
COT |
0.805 | 0.052 | 2 | 0.803 |
TSSK1 |
0.804 | 0.232 | -3 | 0.861 |
ATR |
0.804 | 0.172 | 1 | 0.871 |
PRKD1 |
0.804 | 0.216 | -3 | 0.820 |
TSSK2 |
0.802 | 0.227 | -5 | 0.837 |
MARK4 |
0.800 | 0.152 | 4 | 0.680 |
CLK3 |
0.800 | 0.104 | 1 | 0.787 |
PKN3 |
0.800 | 0.107 | -3 | 0.810 |
DSTYK |
0.799 | 0.065 | 2 | 0.823 |
ATM |
0.799 | 0.192 | 1 | 0.849 |
PIM3 |
0.798 | 0.098 | -3 | 0.829 |
AMPKA1 |
0.798 | 0.131 | -3 | 0.849 |
CAMK1B |
0.797 | 0.090 | -3 | 0.847 |
PRKD2 |
0.796 | 0.165 | -3 | 0.790 |
SIK |
0.796 | 0.171 | -3 | 0.778 |
RAF1 |
0.796 | -0.012 | 1 | 0.795 |
MST4 |
0.795 | 0.079 | 2 | 0.815 |
NLK |
0.795 | 0.044 | 1 | 0.809 |
FAM20C |
0.795 | 0.228 | 2 | 0.686 |
HUNK |
0.794 | 0.101 | 2 | 0.725 |
QSK |
0.794 | 0.158 | 4 | 0.656 |
WNK1 |
0.794 | 0.050 | -2 | 0.861 |
PRPK |
0.794 | -0.093 | -1 | 0.795 |
NEK7 |
0.794 | 0.014 | -3 | 0.796 |
PDHK4 |
0.794 | -0.059 | 1 | 0.806 |
CDC7 |
0.793 | 0.035 | 1 | 0.734 |
IKKB |
0.793 | 0.030 | -2 | 0.738 |
NUAK1 |
0.793 | 0.127 | -3 | 0.806 |
PIM1 |
0.793 | 0.120 | -3 | 0.795 |
CDKL1 |
0.793 | 0.062 | -3 | 0.793 |
CAMK2B |
0.793 | 0.181 | 2 | 0.707 |
PDHK1 |
0.793 | 0.030 | 1 | 0.813 |
AMPKA2 |
0.792 | 0.121 | -3 | 0.828 |
NEK6 |
0.792 | 0.024 | -2 | 0.817 |
PKN2 |
0.791 | 0.067 | -3 | 0.829 |
NIK |
0.791 | 0.045 | -3 | 0.849 |
MLK1 |
0.791 | 0.005 | 2 | 0.770 |
MOS |
0.791 | -0.009 | 1 | 0.760 |
SKMLCK |
0.791 | 0.070 | -2 | 0.840 |
MARK2 |
0.791 | 0.161 | 4 | 0.622 |
CAMK2G |
0.791 | 0.004 | 2 | 0.718 |
BCKDK |
0.791 | 0.083 | -1 | 0.806 |
MTOR |
0.790 | -0.055 | 1 | 0.759 |
BMPR2 |
0.790 | -0.067 | -2 | 0.854 |
TBK1 |
0.790 | -0.032 | 1 | 0.732 |
QIK |
0.789 | 0.109 | -3 | 0.837 |
MAPKAPK2 |
0.789 | 0.162 | -3 | 0.753 |
NIM1 |
0.788 | 0.072 | 3 | 0.680 |
PKCD |
0.788 | 0.065 | 2 | 0.736 |
MAPKAPK3 |
0.788 | 0.119 | -3 | 0.794 |
CAMK2D |
0.788 | 0.104 | -3 | 0.831 |
ULK2 |
0.788 | -0.062 | 2 | 0.732 |
NDR2 |
0.787 | 0.022 | -3 | 0.835 |
SRPK1 |
0.787 | 0.072 | -3 | 0.758 |
CAMLCK |
0.786 | 0.017 | -2 | 0.822 |
DAPK2 |
0.786 | 0.031 | -3 | 0.848 |
PRKD3 |
0.786 | 0.127 | -3 | 0.773 |
GCN2 |
0.786 | -0.107 | 2 | 0.715 |
MARK3 |
0.785 | 0.126 | 4 | 0.634 |
CHK1 |
0.785 | 0.182 | -3 | 0.823 |
ANKRD3 |
0.785 | -0.009 | 1 | 0.849 |
IKKA |
0.785 | 0.064 | -2 | 0.726 |
WNK3 |
0.785 | -0.059 | 1 | 0.804 |
GRK6 |
0.784 | 0.048 | 1 | 0.762 |
RSK2 |
0.784 | 0.068 | -3 | 0.787 |
IKKE |
0.784 | -0.057 | 1 | 0.723 |
MARK1 |
0.783 | 0.150 | 4 | 0.641 |
ERK5 |
0.783 | -0.019 | 1 | 0.702 |
TGFBR2 |
0.783 | -0.026 | -2 | 0.758 |
HIPK4 |
0.783 | 0.049 | 1 | 0.779 |
DNAPK |
0.783 | 0.146 | 1 | 0.817 |
MELK |
0.783 | 0.086 | -3 | 0.816 |
RIPK3 |
0.783 | -0.075 | 3 | 0.577 |
ICK |
0.782 | 0.037 | -3 | 0.826 |
CAMK2A |
0.782 | 0.117 | 2 | 0.682 |
GRK5 |
0.782 | -0.059 | -3 | 0.791 |
CAMK4 |
0.782 | 0.044 | -3 | 0.827 |
CDK8 |
0.782 | 0.052 | 1 | 0.687 |
GRK4 |
0.781 | 0.004 | -2 | 0.809 |
GRK1 |
0.781 | 0.054 | -2 | 0.771 |
CDKL5 |
0.781 | 0.030 | -3 | 0.790 |
NEK9 |
0.781 | -0.062 | 2 | 0.786 |
KIS |
0.781 | 0.063 | 1 | 0.693 |
PKCB |
0.781 | 0.043 | 2 | 0.703 |
CDK5 |
0.781 | 0.066 | 1 | 0.686 |
PKCH |
0.780 | 0.037 | 2 | 0.695 |
NDR1 |
0.780 | -0.013 | -3 | 0.831 |
DLK |
0.780 | -0.061 | 1 | 0.802 |
SSTK |
0.780 | 0.124 | 4 | 0.674 |
SRPK2 |
0.780 | 0.072 | -3 | 0.692 |
IRE1 |
0.779 | -0.037 | 1 | 0.767 |
SMG1 |
0.779 | 0.121 | 1 | 0.846 |
PKACG |
0.779 | 0.022 | -2 | 0.722 |
PKCA |
0.779 | 0.046 | 2 | 0.701 |
P90RSK |
0.779 | 0.038 | -3 | 0.780 |
PKR |
0.779 | 0.020 | 1 | 0.808 |
BRSK1 |
0.779 | 0.100 | -3 | 0.805 |
P70S6KB |
0.778 | 0.011 | -3 | 0.802 |
LATS2 |
0.778 | 0.020 | -5 | 0.601 |
SRPK3 |
0.778 | 0.054 | -3 | 0.724 |
LATS1 |
0.778 | 0.060 | -3 | 0.838 |
MASTL |
0.778 | -0.147 | -2 | 0.797 |
RSK3 |
0.778 | 0.032 | -3 | 0.776 |
BMPR1B |
0.777 | 0.071 | 1 | 0.662 |
SGK3 |
0.777 | 0.066 | -3 | 0.788 |
PHKG1 |
0.777 | 0.035 | -3 | 0.827 |
ULK1 |
0.776 | -0.110 | -3 | 0.735 |
MLK4 |
0.776 | 0.001 | 2 | 0.680 |
MLK3 |
0.776 | -0.018 | 2 | 0.700 |
CLK1 |
0.776 | 0.075 | -3 | 0.775 |
RIPK1 |
0.775 | -0.105 | 1 | 0.807 |
TLK2 |
0.775 | 0.031 | 1 | 0.826 |
PLK1 |
0.775 | -0.023 | -2 | 0.775 |
PKCG |
0.775 | 0.006 | 2 | 0.691 |
BRAF |
0.775 | 0.045 | -4 | 0.725 |
IRE2 |
0.775 | -0.038 | 2 | 0.716 |
CHAK2 |
0.775 | -0.097 | -1 | 0.766 |
NEK2 |
0.775 | -0.020 | 2 | 0.762 |
CDK19 |
0.774 | 0.042 | 1 | 0.651 |
GRK7 |
0.774 | 0.044 | 1 | 0.686 |
MLK2 |
0.774 | -0.091 | 2 | 0.759 |
BRSK2 |
0.774 | 0.029 | -3 | 0.826 |
JNK3 |
0.774 | 0.065 | 1 | 0.648 |
CLK4 |
0.774 | 0.054 | -3 | 0.785 |
ALK4 |
0.773 | -0.017 | -2 | 0.808 |
MNK2 |
0.773 | 0.016 | -2 | 0.767 |
MEK1 |
0.773 | -0.055 | 2 | 0.743 |
WNK4 |
0.773 | 0.002 | -2 | 0.841 |
MSK2 |
0.772 | 0.023 | -3 | 0.757 |
VRK2 |
0.772 | -0.112 | 1 | 0.845 |
TGFBR1 |
0.772 | 0.022 | -2 | 0.791 |
PKCZ |
0.772 | -0.023 | 2 | 0.738 |
MYLK4 |
0.772 | 0.026 | -2 | 0.760 |
PAK1 |
0.772 | -0.009 | -2 | 0.778 |
DYRK2 |
0.772 | 0.042 | 1 | 0.689 |
AKT2 |
0.771 | 0.056 | -3 | 0.726 |
JNK2 |
0.771 | 0.071 | 1 | 0.622 |
CDK1 |
0.771 | 0.042 | 1 | 0.615 |
ZAK |
0.770 | -0.015 | 1 | 0.795 |
PAK3 |
0.770 | -0.027 | -2 | 0.778 |
YSK4 |
0.770 | -0.071 | 1 | 0.739 |
PKACB |
0.770 | 0.056 | -2 | 0.658 |
CAMK1D |
0.770 | 0.112 | -3 | 0.745 |
TLK1 |
0.770 | -0.006 | -2 | 0.819 |
DCAMKL1 |
0.770 | 0.052 | -3 | 0.806 |
PINK1 |
0.769 | -0.025 | 1 | 0.804 |
PIM2 |
0.769 | 0.053 | -3 | 0.770 |
CAMK1G |
0.769 | 0.033 | -3 | 0.771 |
PLK3 |
0.769 | 0.001 | 2 | 0.680 |
MEKK2 |
0.769 | -0.014 | 2 | 0.746 |
MEKK1 |
0.768 | -0.047 | 1 | 0.829 |
MST3 |
0.768 | 0.018 | 2 | 0.777 |
AKT1 |
0.768 | 0.068 | -3 | 0.746 |
P38A |
0.768 | 0.032 | 1 | 0.670 |
TAO3 |
0.768 | 0.020 | 1 | 0.768 |
RSK4 |
0.768 | 0.033 | -3 | 0.763 |
TTBK2 |
0.767 | -0.134 | 2 | 0.641 |
ALK2 |
0.767 | 0.025 | -2 | 0.788 |
PKCT |
0.767 | 0.024 | 2 | 0.706 |
HIPK1 |
0.767 | 0.057 | 1 | 0.703 |
MSK1 |
0.767 | 0.034 | -3 | 0.760 |
HIPK2 |
0.767 | 0.068 | 1 | 0.610 |
MNK1 |
0.767 | -0.002 | -2 | 0.768 |
NEK5 |
0.767 | -0.040 | 1 | 0.820 |
CDK2 |
0.767 | 0.006 | 1 | 0.687 |
CDK13 |
0.767 | 0.011 | 1 | 0.644 |
CLK2 |
0.766 | 0.074 | -3 | 0.770 |
SNRK |
0.766 | -0.055 | 2 | 0.654 |
ACVR2A |
0.766 | -0.019 | -2 | 0.755 |
PKG2 |
0.766 | 0.020 | -2 | 0.649 |
ERK1 |
0.766 | 0.038 | 1 | 0.602 |
CDK18 |
0.766 | 0.041 | 1 | 0.598 |
PHKG2 |
0.766 | 0.045 | -3 | 0.808 |
AURC |
0.766 | 0.008 | -2 | 0.627 |
PAK2 |
0.765 | -0.039 | -2 | 0.758 |
ERK2 |
0.765 | 0.022 | 1 | 0.642 |
DYRK1A |
0.765 | 0.050 | 1 | 0.735 |
SMMLCK |
0.765 | 0.016 | -3 | 0.814 |
MAPKAPK5 |
0.765 | 0.013 | -3 | 0.725 |
MEKK3 |
0.765 | -0.090 | 1 | 0.776 |
P38G |
0.764 | 0.047 | 1 | 0.542 |
PLK4 |
0.764 | -0.053 | 2 | 0.584 |
HRI |
0.764 | -0.106 | -2 | 0.811 |
MEK5 |
0.764 | -0.142 | 2 | 0.756 |
BMPR1A |
0.764 | 0.060 | 1 | 0.656 |
AURA |
0.764 | 0.010 | -2 | 0.606 |
P38B |
0.763 | 0.048 | 1 | 0.596 |
CHAK1 |
0.763 | -0.120 | 2 | 0.699 |
CDK7 |
0.763 | 0.001 | 1 | 0.671 |
AURB |
0.763 | -0.003 | -2 | 0.631 |
ACVR2B |
0.763 | -0.036 | -2 | 0.772 |
PAK6 |
0.762 | 0.018 | -2 | 0.675 |
CDK9 |
0.761 | 0.006 | 1 | 0.652 |
GRK2 |
0.761 | -0.044 | -2 | 0.708 |
DCAMKL2 |
0.761 | 0.016 | -3 | 0.828 |
CHK2 |
0.761 | 0.090 | -3 | 0.684 |
PRKX |
0.761 | 0.064 | -3 | 0.735 |
HIPK3 |
0.761 | 0.034 | 1 | 0.709 |
P38D |
0.761 | 0.071 | 1 | 0.591 |
CDK12 |
0.761 | 0.010 | 1 | 0.624 |
CDK3 |
0.760 | 0.047 | 1 | 0.562 |
PERK |
0.760 | -0.114 | -2 | 0.786 |
DRAK1 |
0.760 | -0.076 | 1 | 0.719 |
CDK17 |
0.760 | 0.029 | 1 | 0.551 |
NEK8 |
0.760 | -0.060 | 2 | 0.771 |
PRP4 |
0.760 | -0.022 | -3 | 0.662 |
DAPK3 |
0.760 | 0.054 | -3 | 0.811 |
PKCE |
0.760 | 0.038 | 2 | 0.685 |
IRAK4 |
0.760 | -0.091 | 1 | 0.792 |
PASK |
0.760 | 0.003 | -3 | 0.842 |
TAO2 |
0.759 | -0.019 | 2 | 0.793 |
PDK1 |
0.759 | -0.006 | 1 | 0.804 |
PKCI |
0.758 | -0.004 | 2 | 0.713 |
PKN1 |
0.758 | 0.061 | -3 | 0.755 |
GAK |
0.758 | 0.014 | 1 | 0.761 |
EEF2K |
0.758 | 0.006 | 3 | 0.698 |
CK1E |
0.758 | -0.011 | -3 | 0.535 |
PKACA |
0.757 | 0.044 | -2 | 0.603 |
MST2 |
0.757 | 0.006 | 1 | 0.773 |
MPSK1 |
0.757 | -0.020 | 1 | 0.746 |
CAMK1A |
0.757 | 0.098 | -3 | 0.693 |
TNIK |
0.757 | 0.027 | 3 | 0.688 |
CDK14 |
0.757 | 0.029 | 1 | 0.644 |
CDK16 |
0.756 | 0.051 | 1 | 0.564 |
TAK1 |
0.756 | 0.024 | 1 | 0.825 |
GSK3A |
0.755 | -0.029 | 4 | 0.326 |
SGK1 |
0.754 | 0.062 | -3 | 0.657 |
IRAK1 |
0.754 | -0.120 | -1 | 0.663 |
DYRK1B |
0.754 | 0.029 | 1 | 0.641 |
MAP3K15 |
0.754 | -0.041 | 1 | 0.774 |
MINK |
0.754 | -0.018 | 1 | 0.771 |
DYRK3 |
0.753 | 0.030 | 1 | 0.713 |
HGK |
0.753 | -0.016 | 3 | 0.689 |
GCK |
0.753 | -0.042 | 1 | 0.761 |
DYRK4 |
0.753 | 0.038 | 1 | 0.621 |
GSK3B |
0.752 | -0.064 | 4 | 0.319 |
P70S6K |
0.752 | -0.010 | -3 | 0.729 |
JNK1 |
0.752 | 0.037 | 1 | 0.594 |
BUB1 |
0.752 | 0.110 | -5 | 0.792 |
GRK3 |
0.751 | -0.021 | -2 | 0.671 |
CAMKK1 |
0.751 | -0.105 | -2 | 0.717 |
NEK11 |
0.751 | -0.151 | 1 | 0.795 |
CDK6 |
0.751 | 0.032 | 1 | 0.633 |
CDK10 |
0.751 | 0.032 | 1 | 0.635 |
MEKK6 |
0.750 | -0.071 | 1 | 0.765 |
CK1D |
0.750 | -0.009 | -3 | 0.486 |
AKT3 |
0.750 | 0.046 | -3 | 0.672 |
ERK7 |
0.750 | 0.018 | 2 | 0.531 |
SBK |
0.749 | 0.091 | -3 | 0.623 |
LRRK2 |
0.749 | -0.083 | 2 | 0.790 |
PLK2 |
0.749 | 0.025 | -3 | 0.722 |
NEK4 |
0.749 | -0.108 | 1 | 0.784 |
DAPK1 |
0.749 | 0.015 | -3 | 0.795 |
YSK1 |
0.749 | -0.001 | 2 | 0.771 |
CK1A2 |
0.748 | -0.017 | -3 | 0.492 |
NEK1 |
0.748 | -0.054 | 1 | 0.787 |
CAMKK2 |
0.748 | -0.097 | -2 | 0.705 |
ROCK2 |
0.748 | 0.034 | -3 | 0.808 |
VRK1 |
0.748 | -0.086 | 2 | 0.779 |
CDK4 |
0.748 | 0.033 | 1 | 0.612 |
CK2A2 |
0.748 | 0.054 | 1 | 0.539 |
CK1G1 |
0.748 | -0.029 | -3 | 0.513 |
KHS2 |
0.748 | 0.009 | 1 | 0.764 |
MRCKB |
0.748 | 0.028 | -3 | 0.764 |
MAK |
0.747 | 0.072 | -2 | 0.693 |
MRCKA |
0.747 | 0.021 | -3 | 0.779 |
LKB1 |
0.747 | -0.110 | -3 | 0.791 |
HPK1 |
0.747 | -0.047 | 1 | 0.744 |
PAK5 |
0.747 | -0.011 | -2 | 0.621 |
MST1 |
0.746 | -0.054 | 1 | 0.760 |
KHS1 |
0.746 | -0.019 | 1 | 0.754 |
TTBK1 |
0.744 | -0.129 | 2 | 0.562 |
OSR1 |
0.744 | 0.003 | 2 | 0.740 |
LOK |
0.743 | -0.068 | -2 | 0.733 |
RIPK2 |
0.743 | -0.121 | 1 | 0.768 |
MOK |
0.740 | 0.043 | 1 | 0.678 |
TTK |
0.739 | -0.023 | -2 | 0.790 |
DMPK1 |
0.738 | 0.036 | -3 | 0.784 |
PAK4 |
0.738 | -0.024 | -2 | 0.625 |
MEK2 |
0.738 | -0.143 | 2 | 0.735 |
ROCK1 |
0.737 | 0.018 | -3 | 0.775 |
SLK |
0.736 | -0.096 | -2 | 0.677 |
MYO3A |
0.735 | -0.015 | 1 | 0.770 |
NEK3 |
0.735 | -0.097 | 1 | 0.777 |
CK2A1 |
0.735 | 0.011 | 1 | 0.514 |
ALPHAK3 |
0.735 | 0.008 | -1 | 0.724 |
STK33 |
0.735 | -0.147 | 2 | 0.550 |
PBK |
0.734 | -0.055 | 1 | 0.685 |
MYO3B |
0.734 | -0.027 | 2 | 0.769 |
CRIK |
0.732 | 0.023 | -3 | 0.739 |
PKG1 |
0.732 | 0.000 | -2 | 0.576 |
TAO1 |
0.731 | -0.043 | 1 | 0.731 |
BIKE |
0.729 | 0.004 | 1 | 0.645 |
ASK1 |
0.729 | -0.087 | 1 | 0.761 |
HASPIN |
0.727 | -0.060 | -1 | 0.604 |
STLK3 |
0.722 | -0.067 | 1 | 0.758 |
YANK3 |
0.722 | -0.064 | 2 | 0.338 |
PDHK3_TYR |
0.717 | 0.003 | 4 | 0.683 |
AAK1 |
0.715 | 0.031 | 1 | 0.544 |
PKMYT1_TYR |
0.714 | -0.041 | 3 | 0.693 |
CK1A |
0.714 | -0.036 | -3 | 0.400 |
BMPR2_TYR |
0.713 | 0.002 | -1 | 0.807 |
PINK1_TYR |
0.712 | -0.058 | 1 | 0.779 |
TYK2 |
0.711 | -0.001 | 1 | 0.789 |
MAP2K6_TYR |
0.711 | -0.053 | -1 | 0.832 |
TESK1_TYR |
0.710 | -0.113 | 3 | 0.730 |
MAP2K4_TYR |
0.710 | -0.110 | -1 | 0.831 |
MAP2K7_TYR |
0.710 | -0.165 | 2 | 0.779 |
PDHK4_TYR |
0.709 | -0.054 | 2 | 0.780 |
DDR1 |
0.709 | -0.021 | 4 | 0.694 |
RET |
0.709 | -0.032 | 1 | 0.787 |
CK1G3 |
0.709 | -0.011 | -3 | 0.356 |
ROS1 |
0.708 | -0.038 | 3 | 0.620 |
JAK2 |
0.707 | -0.023 | 1 | 0.796 |
LIMK2_TYR |
0.707 | -0.058 | -3 | 0.848 |
PDHK1_TYR |
0.707 | -0.077 | -1 | 0.821 |
TNNI3K_TYR |
0.707 | 0.058 | 1 | 0.824 |
MST1R |
0.704 | -0.075 | 3 | 0.642 |
FLT3 |
0.704 | 0.007 | 3 | 0.635 |
CSF1R |
0.704 | -0.051 | 3 | 0.628 |
EPHA6 |
0.703 | -0.018 | -1 | 0.794 |
TYRO3 |
0.703 | -0.090 | 3 | 0.648 |
LIMK1_TYR |
0.702 | -0.146 | 2 | 0.791 |
PDGFRB |
0.701 | -0.048 | 3 | 0.647 |
JAK3 |
0.700 | -0.045 | 1 | 0.769 |
FER |
0.700 | -0.057 | 1 | 0.773 |
INSRR |
0.699 | -0.056 | 3 | 0.613 |
EPHB4 |
0.699 | -0.057 | -1 | 0.790 |
KDR |
0.697 | -0.057 | 3 | 0.586 |
FGFR2 |
0.697 | -0.061 | 3 | 0.639 |
ABL2 |
0.696 | -0.058 | -1 | 0.728 |
KIT |
0.696 | -0.071 | 3 | 0.639 |
JAK1 |
0.696 | -0.039 | 1 | 0.754 |
YANK2 |
0.695 | -0.078 | 2 | 0.355 |
FGR |
0.694 | -0.111 | 1 | 0.755 |
EPHB1 |
0.694 | -0.044 | 1 | 0.767 |
ALK |
0.694 | -0.061 | 3 | 0.589 |
YES1 |
0.694 | -0.085 | -1 | 0.718 |
FGFR1 |
0.693 | -0.072 | 3 | 0.617 |
DDR2 |
0.693 | -0.009 | 3 | 0.590 |
TNK1 |
0.693 | -0.097 | 3 | 0.628 |
WEE1_TYR |
0.692 | -0.059 | -1 | 0.687 |
ITK |
0.692 | -0.062 | -1 | 0.694 |
PDGFRA |
0.692 | -0.104 | 3 | 0.640 |
EPHA4 |
0.690 | -0.068 | 2 | 0.678 |
HCK |
0.690 | -0.094 | -1 | 0.706 |
EPHB2 |
0.690 | -0.042 | -1 | 0.765 |
MET |
0.689 | -0.085 | 3 | 0.614 |
EPHB3 |
0.689 | -0.066 | -1 | 0.771 |
TXK |
0.689 | -0.059 | 1 | 0.713 |
NEK10_TYR |
0.689 | -0.097 | 1 | 0.655 |
LCK |
0.688 | -0.063 | -1 | 0.700 |
TEK |
0.688 | -0.133 | 3 | 0.599 |
INSR |
0.688 | -0.072 | 3 | 0.587 |
ABL1 |
0.688 | -0.108 | -1 | 0.713 |
PTK6 |
0.687 | -0.099 | -1 | 0.634 |
TEC |
0.687 | -0.068 | -1 | 0.640 |
LTK |
0.686 | -0.092 | 3 | 0.596 |
FLT1 |
0.686 | -0.071 | -1 | 0.786 |
CK1G2 |
0.686 | -0.045 | -3 | 0.438 |
BMX |
0.686 | -0.053 | -1 | 0.630 |
BTK |
0.686 | -0.112 | -1 | 0.667 |
FGFR3 |
0.686 | -0.085 | 3 | 0.616 |
TNK2 |
0.686 | -0.137 | 3 | 0.578 |
NTRK2 |
0.685 | -0.100 | 3 | 0.594 |
FLT4 |
0.685 | -0.095 | 3 | 0.585 |
ERBB2 |
0.685 | -0.101 | 1 | 0.717 |
NTRK1 |
0.684 | -0.126 | -1 | 0.787 |
MERTK |
0.684 | -0.102 | 3 | 0.605 |
SRMS |
0.684 | -0.126 | 1 | 0.750 |
BLK |
0.683 | -0.073 | -1 | 0.705 |
AXL |
0.682 | -0.145 | 3 | 0.612 |
FRK |
0.682 | -0.077 | -1 | 0.733 |
EPHA7 |
0.680 | -0.085 | 2 | 0.694 |
NTRK3 |
0.680 | -0.093 | -1 | 0.746 |
EGFR |
0.679 | -0.037 | 1 | 0.636 |
EPHA3 |
0.679 | -0.109 | 2 | 0.662 |
LYN |
0.678 | -0.093 | 3 | 0.566 |
FYN |
0.677 | -0.070 | -1 | 0.663 |
EPHA5 |
0.677 | -0.058 | 2 | 0.678 |
EPHA1 |
0.676 | -0.128 | 3 | 0.588 |
IGF1R |
0.676 | -0.072 | 3 | 0.548 |
MATK |
0.676 | -0.113 | -1 | 0.661 |
FGFR4 |
0.674 | -0.061 | -1 | 0.714 |
CSK |
0.674 | -0.098 | 2 | 0.687 |
SYK |
0.673 | -0.025 | -1 | 0.716 |
EPHA8 |
0.672 | -0.088 | -1 | 0.723 |
PTK2 |
0.668 | -0.045 | -1 | 0.720 |
SRC |
0.668 | -0.120 | -1 | 0.660 |
MUSK |
0.667 | -0.123 | 1 | 0.602 |
PTK2B |
0.667 | -0.140 | -1 | 0.667 |
ERBB4 |
0.664 | -0.068 | 1 | 0.626 |
EPHA2 |
0.662 | -0.097 | -1 | 0.721 |
FES |
0.651 | -0.136 | -1 | 0.602 |
ZAP70 |
0.650 | -0.067 | -1 | 0.643 |