Motif 978 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00287 | RFXAP | S241 | ochoa | Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) | Part of the RFX complex that binds to the X-box of MHC II promoters. |
| O00422 | SAP18 | S119 | ochoa | Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18) | Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. {ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:20966198, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:9150135}. |
| O14686 | KMT2D | S1606 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S21 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14879 | IFIT3 | S203 | ochoa | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}. |
| O14936 | CASK | S314 | ochoa | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O43194 | GPR39 | S396 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O43379 | WDR62 | S1405 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43464 | HTRA2 | S400 | psp | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}. |
| O43741 | PRKAB2 | S39 | ochoa | 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| O60343 | TBC1D4 | S344 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60506 | SYNCRIP | S159 | ochoa | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}. |
| O75152 | ZC3H11A | S196 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75223 | GGCT | S37 | ochoa | Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}. |
| O75376 | NCOR1 | S2202 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75995 | SASH3 | S243 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O94901 | SUN1 | S138 | psp | SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). {ECO:0000250|UniProtKB:Q9D666, ECO:0000269|PubMed:18039933, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:24375709}. |
| O95382 | MAP3K6 | S783 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| O96019 | ACTL6A | S195 | psp | Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P00505 | GOT2 | S143 | ochoa | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
| P00533 | EGFR | S1153 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02679 | FGG | S404 | ochoa | Fibrinogen gamma chain | Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P09086 | POU2F2 | S279 | ochoa | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250|UniProtKB:Q00196, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980}. |
| P13010 | XRCC5 | S191 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13805 | TNNT1 | S259 | ochoa | Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P14649 | MYL6B | S114 | ochoa | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | Regulatory light chain of myosin. Does not bind calcium. |
| P20340 | RAB6A | S179 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P25391 | LAMA1 | S3048 | ochoa | Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P28749 | RBL1 | S776 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P31629 | HIVEP2 | S374 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P33993 | MCM7 | S365 | psp | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35240 | NF2 | S566 | ochoa | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P35520 | CBS | S525 | psp | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}. |
| P36896 | ACVR1B | S168 | ochoa | Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) | Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. {ECO:0000269|PubMed:12364468, ECO:0000269|PubMed:12639945, ECO:0000269|PubMed:18039968, ECO:0000269|PubMed:20226172, ECO:0000269|PubMed:8196624, ECO:0000269|PubMed:9032295, ECO:0000269|PubMed:9892009}. |
| P37802 | TAGLN2 | S83 | psp | Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) | None |
| P38398 | BRCA1 | S1271 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P39019 | RPS19 | S93 | ochoa | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P42694 | HELZ | S1179 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P43121 | MCAM | S603 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P49792 | RANBP2 | S21 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51398 | DAP3 | S185 | psp | Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}. |
| P52569 | SLC7A2 | S455 | ochoa | Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) | Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}. |
| P53667 | LIMK1 | S210 | ochoa | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. |
| P57075 | UBASH3A | S369 | ochoa | Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}. |
| P60660 | MYL6 | S57 | ochoa | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | Regulatory light chain of myosin. Does not bind calcium. |
| Q00872 | MYBPC1 | S474 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q08499 | PDE4D | S305 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q12923 | PTPN13 | S240 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13428 | TCOF1 | S503 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13554 | CAMK2B | S358 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q14137 | BOP1 | S598 | ochoa | Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. |
| Q14155 | ARHGEF7 | S148 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14690 | PDCD11 | S1357 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q15311 | RALBP1 | S353 | psp | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q16656 | NRF1 | S138 | ochoa | Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) | Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. |
| Q16822 | PCK2 | S304 | ochoa | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) | Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:28955899). {ECO:0000269|PubMed:28955899}. |
| Q16828 | DUSP6 | S300 | psp | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}. |
| Q5CZC0 | FSIP2 | S3181 | ochoa | Fibrous sheath-interacting protein 2 | Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}. |
| Q5SGD2 | PPM1L | S213 | ochoa | Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) | Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269|PubMed:17456047}. |
| Q5SRI9 | MANEA | S289 | ochoa | Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin) | None |
| Q5T7B8 | KIF24 | S1268 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5VYS8 | TUT7 | S939 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q5VZK9 | CARMIL1 | S960 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q5W0B1 | OBI1 | S553 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6P0N0 | MIS18BP1 | S335 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P4F7 | ARHGAP11A | S340 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P9A1 | ZNF530 | S131 | ochoa | Zinc finger protein 530 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6T310 | RASL11A | S217 | ochoa | Ras-like protein family member 11A (EC 3.6.5.2) | Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). {ECO:0000250}. |
| Q6XZF7 | DNMBP | S518 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q7L7V1 | DHX32 | S562 | ochoa | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) | None |
| Q7L8J4 | SH3BP5L | S343 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
| Q7Z6M1 | RABEPK | S191 | ochoa | Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) | Rab9 effector required for endosome to trans-Golgi network (TGN) transport. {ECO:0000269|PubMed:9230071}. |
| Q86TU7 | SETD3 | S512 | ochoa | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
| Q86XL3 | ANKLE2 | S875 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IVF2 | AHNAK2 | S2175 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4320 | ochoa | Protein AHNAK2 | None |
| Q8IVJ1 | SLC41A1 | S89 | ochoa | Solute carrier family 41 member 1 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}. |
| Q8NCF5 | NFATC2IP | S127 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NDX5 | PHC3 | S229 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8TC05 | MDM1 | S263 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TEQ6 | GEMIN5 | S1267 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8TEV9 | SMCR8 | S638 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WWQ0 | PHIP | S1243 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WXI7 | MUC16 | S12481 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q92786 | PROX1 | S199 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92834 | RPGR | S518 | ochoa | X-linked retinitis pigmentosa GTPase regulator | Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:20631154). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (PubMed:20631154). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (By similarity). Involved in photoreceptor integrity (By similarity). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (PubMed:21933838). May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). {ECO:0000250|UniProtKB:Q9R0X5, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:21933838}. |
| Q96C12 | ARMC5 | S341 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96DG6 | CMBL | S223 | ochoa | Carboxymethylenebutenolidase homolog (EC 3.1.-.-) | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
| Q96EK5 | KIFBP | S500 | ochoa | KIF-binding protein (KIF1-binding protein) (Kinesin family binding protein) | Activator of KIF1B plus-end-directed microtubule motor activity (PubMed:16225668). Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. {ECO:0000269|PubMed:16225668, ECO:0000269|PubMed:20621975, ECO:0000269|PubMed:23427148}. |
| Q96GX5 | MASTL | S277 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96PY6 | NEK1 | S798 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96Q45 | TMEM237 | S205 | ochoa | Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein) | Component of the transition zone in primary cilia. Required for ciliogenesis. {ECO:0000269|PubMed:22152675}. |
| Q96R06 | SPAG5 | S135 | ochoa|psp | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96SN8 | CDK5RAP2 | S843 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99666 | RGPD5 | S21 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99755 | PIP5K1A | S458 | ochoa | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}. |
| Q9BPZ7 | MAPKAP1 | S447 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BUF5 | TUBB6 | S239 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BY89 | KIAA1671 | S518 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0B0 | UNK | S85 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0C9 | UBE2O | S1231 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H089 | LSG1 | S97 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H5Q4 | TFB2M | S197 | psp | Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2) | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:12068295, PubMed:15526033, PubMed:20410300, PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033, PubMed:29149603). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:29149603, ECO:0000305|PubMed:12897151, ECO:0000305|PubMed:17031457}. |
| Q9H7N4 | SCAF1 | S161 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HBI1 | PARVB | S254 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
| Q9HCE3 | ZNF532 | S456 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9NR09 | BIRC6 | S1248 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NS00 | C1GALT1 | S69 | ochoa | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1) | Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed:11677243). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity). {ECO:0000250|UniProtKB:Q7K237, ECO:0000250|UniProtKB:Q9JJ06, ECO:0000269|PubMed:11677243}. |
| Q9NYL9 | TMOD3 | S59 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9P270 | SLAIN2 | S160 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2M4 | TBC1D14 | S295 | ochoa | TBC1 domain family member 14 | Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}. |
| Q9UBB5 | MBD2 | S183 | ochoa | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| Q9UGU0 | TCF20 | S1675 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHI6 | DDX20 | S502 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9ULD9 | ZNF608 | S895 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULE3 | DENND2A | S404 | ochoa | DENN domain-containing protein 2A | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}. |
| Q9UNM6 | PSMD13 | S191 | ochoa | 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q9UPQ0 | LIMCH1 | S907 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQK1 | PPP1R3C | S33 | ochoa|psp | Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG) | Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:8985175}. |
| Q9Y230 | RUVBL2 | S437 | ochoa | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| P31153 | MAT2A | S247 | Sugiyama | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. |
| P27797 | CALR | S80 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| Q14457 | BECN1 | S279 | PSP | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:37776275, ECO:0000269|PubMed:9765397}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.; FUNCTION: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269|PubMed:9765397}. |
| Q07866 | KLC1 | S389 | Sugiyama | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
| Q9H0B6 | KLC2 | S374 | Sugiyama | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9NSK0 | KLC4 | S387 | Sugiyama | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q00610 | CLTC | S902 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9BXP5 | SRRT | S703 | Sugiyama | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| P06756 | ITGAV | S127 | Sugiyama | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). {ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
| Q09028 | RBBP4 | S159 | Sugiyama | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q14C86 | GAPVD1 | S1019 | Sugiyama | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}. |
| P60484 | PTEN | S179 | SIGNOR | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| Q86Z02 | HIPK1 | S342 | Sugiyama | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q9H2X6 | HIPK2 | S351 | Sugiyama | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H422 | HIPK3 | S349 | Sugiyama | Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}. |
| Q14524 | SCN5A | S61 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| P15311 | EZR | S149 | Sugiyama | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.000111 | 3.954 |
| R-HSA-373760 | L1CAM interactions | 0.000369 | 3.433 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.000368 | 3.434 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.000412 | 3.385 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.000503 | 3.298 |
| R-HSA-397014 | Muscle contraction | 0.000600 | 3.222 |
| R-HSA-983189 | Kinesins | 0.000659 | 3.181 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.002127 | 2.672 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.002142 | 2.669 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.002185 | 2.660 |
| R-HSA-199991 | Membrane Trafficking | 0.003087 | 2.511 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.003710 | 2.431 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.003515 | 2.454 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.003961 | 2.402 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.006612 | 2.180 |
| R-HSA-390522 | Striated Muscle Contraction | 0.007816 | 2.107 |
| R-HSA-1538133 | G0 and Early G1 | 0.006799 | 2.168 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.005071 | 2.295 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.007297 | 2.137 |
| R-HSA-6807070 | PTEN Regulation | 0.005092 | 2.293 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.004693 | 2.329 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.007576 | 2.121 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.005844 | 2.233 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.006841 | 2.165 |
| R-HSA-1640170 | Cell Cycle | 0.006705 | 2.174 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.007980 | 2.098 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.007297 | 2.137 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005592 | 2.252 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.004665 | 2.331 |
| R-HSA-74160 | Gene expression (Transcription) | 0.008018 | 2.096 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.009249 | 2.034 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.009414 | 2.026 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.009685 | 2.014 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.010131 | 1.994 |
| R-HSA-422475 | Axon guidance | 0.011901 | 1.924 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.011793 | 1.928 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.012749 | 1.895 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.012845 | 1.891 |
| R-HSA-5578768 | Physiological factors | 0.014307 | 1.844 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.013465 | 1.871 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.014519 | 1.838 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.014307 | 1.844 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.013878 | 1.858 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.019799 | 1.703 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.019799 | 1.703 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.017436 | 1.759 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.020826 | 1.681 |
| R-HSA-437239 | Recycling pathway of L1 | 0.018239 | 1.739 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.019099 | 1.719 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.016280 | 1.788 |
| R-HSA-69275 | G2/M Transition | 0.017693 | 1.752 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.018457 | 1.734 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.015431 | 1.812 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.015730 | 1.803 |
| R-HSA-4839726 | Chromatin organization | 0.019206 | 1.717 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.019827 | 1.703 |
| R-HSA-1280218 | Adaptive Immune System | 0.020915 | 1.680 |
| R-HSA-9675108 | Nervous system development | 0.018616 | 1.730 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.019099 | 1.719 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.024850 | 1.605 |
| R-HSA-212436 | Generic Transcription Pathway | 0.024413 | 1.612 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.024513 | 1.611 |
| R-HSA-162582 | Signal Transduction | 0.024966 | 1.603 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.025886 | 1.587 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.025232 | 1.598 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.026376 | 1.579 |
| R-HSA-445144 | Signal transduction by L1 | 0.026376 | 1.579 |
| R-HSA-1483255 | PI Metabolism | 0.027487 | 1.561 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.028345 | 1.548 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 0.029552 | 1.529 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.030261 | 1.519 |
| R-HSA-191859 | snRNP Assembly | 0.030261 | 1.519 |
| R-HSA-163282 | Mitochondrial transcription initiation | 0.029552 | 1.529 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.032316 | 1.491 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.032316 | 1.491 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.048769 | 1.312 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.048769 | 1.312 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.058235 | 1.235 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.076888 | 1.114 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.076888 | 1.114 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.076888 | 1.114 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.076888 | 1.114 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.086076 | 1.065 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.095174 | 1.021 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.104181 | 0.982 |
| R-HSA-196025 | Formation of annular gap junctions | 0.104181 | 0.982 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.104181 | 0.982 |
| R-HSA-190873 | Gap junction degradation | 0.113099 | 0.947 |
| R-HSA-164843 | 2-LTR circle formation | 0.121929 | 0.914 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.147899 | 0.830 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.046043 | 1.337 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.048480 | 1.314 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.164786 | 0.783 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.164786 | 0.783 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.173104 | 0.762 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.173104 | 0.762 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.181340 | 0.742 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.181340 | 0.742 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.181340 | 0.742 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.181340 | 0.742 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.197569 | 0.704 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.213478 | 0.671 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.221314 | 0.655 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.221314 | 0.655 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.221314 | 0.655 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.221314 | 0.655 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.221314 | 0.655 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.229073 | 0.640 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.099161 | 1.004 |
| R-HSA-774815 | Nucleosome assembly | 0.099161 | 1.004 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.236755 | 0.626 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.236755 | 0.626 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.236755 | 0.626 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.251892 | 0.599 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.251892 | 0.599 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.259348 | 0.586 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.266730 | 0.574 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.148605 | 0.828 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.295534 | 0.529 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.302558 | 0.519 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.166033 | 0.780 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.309512 | 0.509 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.309512 | 0.509 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.176654 | 0.753 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.323214 | 0.491 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.323214 | 0.491 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.329963 | 0.482 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.194579 | 0.711 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.227352 | 0.643 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.245734 | 0.610 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.253105 | 0.597 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.274039 | 0.562 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.229073 | 0.640 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.229073 | 0.640 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.197569 | 0.704 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.197569 | 0.704 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.124921 | 0.903 |
| R-HSA-182971 | EGFR downregulation | 0.053491 | 1.272 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.302558 | 0.519 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.260482 | 0.584 |
| R-HSA-177929 | Signaling by EGFR | 0.134957 | 0.870 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.205563 | 0.687 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.293306 | 0.533 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.108635 | 0.964 |
| R-HSA-180292 | GAB1 signalosome | 0.205563 | 0.687 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.259348 | 0.586 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.295534 | 0.529 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.113099 | 0.947 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.113099 | 0.947 |
| R-HSA-9609690 | HCMV Early Events | 0.065867 | 1.181 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.086925 | 1.061 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.102292 | 0.990 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.102292 | 0.990 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.102292 | 0.990 |
| R-HSA-9620244 | Long-term potentiation | 0.266730 | 0.574 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.302558 | 0.519 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.121929 | 0.914 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.147899 | 0.830 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.173104 | 0.762 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.221314 | 0.655 |
| R-HSA-1221632 | Meiotic synapsis | 0.124921 | 0.903 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.302558 | 0.519 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.309512 | 0.509 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.323214 | 0.491 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.067327 | 1.172 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.111268 | 0.954 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.111268 | 0.954 |
| R-HSA-354192 | Integrin signaling | 0.323214 | 0.491 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.329963 | 0.482 |
| R-HSA-3000157 | Laminin interactions | 0.039020 | 1.409 |
| R-HSA-9930044 | Nuclear RNA decay | 0.323214 | 0.491 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.218639 | 0.660 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.323214 | 0.491 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.302558 | 0.519 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.236755 | 0.626 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.187379 | 0.727 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.102292 | 0.990 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.034589 | 1.461 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.095174 | 1.021 |
| R-HSA-176974 | Unwinding of DNA | 0.113099 | 0.947 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.121929 | 0.914 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.121929 | 0.914 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.121929 | 0.914 |
| R-HSA-429947 | Deadenylation of mRNA | 0.036779 | 1.434 |
| R-HSA-202670 | ERKs are inactivated | 0.139328 | 0.856 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.147899 | 0.830 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.046043 | 1.337 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.156384 | 0.806 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.189495 | 0.722 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.069536 | 1.158 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.197569 | 0.704 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.236755 | 0.626 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.244361 | 0.612 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.121618 | 0.915 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.281275 | 0.551 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.309512 | 0.509 |
| R-HSA-3928664 | Ephrin signaling | 0.205563 | 0.687 |
| R-HSA-3322077 | Glycogen synthesis | 0.221314 | 0.655 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.076064 | 1.119 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.302558 | 0.519 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.197569 | 0.704 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.131592 | 0.881 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.076888 | 1.114 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.181340 | 0.742 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.205563 | 0.687 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.105450 | 0.977 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.244361 | 0.612 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.121618 | 0.915 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.155531 | 0.808 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.329963 | 0.482 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.194579 | 0.711 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.178027 | 0.750 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.131015 | 0.883 |
| R-HSA-1500620 | Meiosis | 0.238372 | 0.623 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.274370 | 0.562 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.121618 | 0.915 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.190974 | 0.719 |
| R-HSA-9609646 | HCMV Infection | 0.135372 | 0.868 |
| R-HSA-190828 | Gap junction trafficking | 0.096058 | 1.017 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.275239 | 0.560 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.112145 | 0.950 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 0.039208 | 1.407 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.113099 | 0.947 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.113099 | 0.947 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.139328 | 0.856 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.205563 | 0.687 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.213478 | 0.671 |
| R-HSA-1181150 | Signaling by NODAL | 0.221314 | 0.655 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.048411 | 1.315 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.316397 | 0.500 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.187379 | 0.727 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.220027 | 0.658 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.033166 | 1.479 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.124921 | 0.903 |
| R-HSA-216083 | Integrin cell surface interactions | 0.212722 | 0.672 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.066762 | 1.175 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.173104 | 0.762 |
| R-HSA-1502540 | Signaling by Activin | 0.173104 | 0.762 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.266730 | 0.574 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.266730 | 0.574 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.111844 | 0.951 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.302558 | 0.519 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.323214 | 0.491 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.051355 | 1.289 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.309512 | 0.509 |
| R-HSA-5689603 | UCH proteinases | 0.205443 | 0.687 |
| R-HSA-3000170 | Syndecan interactions | 0.034589 | 1.461 |
| R-HSA-8953854 | Metabolism of RNA | 0.150519 | 0.822 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.147899 | 0.830 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.064027 | 1.194 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.281275 | 0.551 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.281275 | 0.551 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.309512 | 0.509 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.190974 | 0.719 |
| R-HSA-69481 | G2/M Checkpoints | 0.170662 | 0.768 |
| R-HSA-68882 | Mitotic Anaphase | 0.211883 | 0.674 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.033781 | 1.471 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.213962 | 0.670 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.121929 | 0.914 |
| R-HSA-68886 | M Phase | 0.217500 | 0.663 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.323214 | 0.491 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.084605 | 1.073 |
| R-HSA-3000178 | ECM proteoglycans | 0.187379 | 0.727 |
| R-HSA-162592 | Integration of provirus | 0.139328 | 0.856 |
| R-HSA-69206 | G1/S Transition | 0.052907 | 1.276 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.238372 | 0.623 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.220027 | 0.658 |
| R-HSA-9613354 | Lipophagy | 0.113099 | 0.947 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.147899 | 0.830 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.147899 | 0.830 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.147899 | 0.830 |
| R-HSA-964739 | N-glycan trimming and elongation in the cis-Golgi | 0.164786 | 0.783 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.164786 | 0.783 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.173104 | 0.762 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.173104 | 0.762 |
| R-HSA-3229121 | Glycogen storage diseases | 0.197569 | 0.704 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.274039 | 0.562 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.145167 | 0.838 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.309512 | 0.509 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.329963 | 0.482 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.329963 | 0.482 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.205443 | 0.687 |
| R-HSA-1632852 | Macroautophagy | 0.210874 | 0.676 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.069036 | 1.161 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.303067 | 0.518 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.051355 | 1.289 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.304693 | 0.516 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.189495 | 0.722 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.055930 | 1.252 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.312028 | 0.506 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.043377 | 1.363 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.164786 | 0.783 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.274039 | 0.562 |
| R-HSA-4086400 | PCP/CE pathway | 0.212722 | 0.672 |
| R-HSA-69242 | S Phase | 0.231710 | 0.635 |
| R-HSA-9612973 | Autophagy | 0.252905 | 0.597 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.242052 | 0.616 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.198442 | 0.702 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.109170 | 0.962 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.260127 | 0.585 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.039020 | 1.409 |
| R-HSA-9659379 | Sensory processing of sound | 0.216372 | 0.665 |
| R-HSA-168255 | Influenza Infection | 0.138087 | 0.860 |
| R-HSA-8964038 | LDL clearance | 0.244361 | 0.612 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.133067 | 0.876 |
| R-HSA-373755 | Semaphorin interactions | 0.159017 | 0.799 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.210715 | 0.676 |
| R-HSA-210990 | PECAM1 interactions | 0.130672 | 0.884 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.164786 | 0.783 |
| R-HSA-8854214 | TBC/RABGAPs | 0.092984 | 1.032 |
| R-HSA-198753 | ERK/MAPK targets | 0.229073 | 0.640 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.274039 | 0.562 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.309512 | 0.509 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.176654 | 0.753 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.323214 | 0.491 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.212722 | 0.672 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.146806 | 0.833 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.221314 | 0.655 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.231022 | 0.636 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.198192 | 0.703 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.244361 | 0.612 |
| R-HSA-69190 | DNA strand elongation | 0.316397 | 0.500 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.319347 | 0.496 |
| R-HSA-73886 | Chromosome Maintenance | 0.153844 | 0.813 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.158594 | 0.800 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.101932 | 0.992 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.213478 | 0.671 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.134957 | 0.870 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.312028 | 0.506 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.298735 | 0.525 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.134957 | 0.870 |
| R-HSA-174403 | Glutathione synthesis and recycling | 0.236755 | 0.626 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.281275 | 0.551 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.316397 | 0.500 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.323214 | 0.491 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.301881 | 0.520 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.069536 | 1.158 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.306117 | 0.514 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.190974 | 0.719 |
| R-HSA-5688426 | Deubiquitination | 0.142894 | 0.845 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.104181 | 0.982 |
| R-HSA-200425 | Carnitine shuttle | 0.251892 | 0.599 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.288440 | 0.540 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.183793 | 0.736 |
| R-HSA-1266738 | Developmental Biology | 0.243274 | 0.614 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.213478 | 0.671 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.274039 | 0.562 |
| R-HSA-5576891 | Cardiac conduction | 0.061045 | 1.214 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.309512 | 0.509 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.104542 | 0.981 |
| R-HSA-9663891 | Selective autophagy | 0.253105 | 0.597 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.298594 | 0.525 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.244361 | 0.612 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.251892 | 0.599 |
| R-HSA-180024 | DARPP-32 events | 0.295534 | 0.529 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.323214 | 0.491 |
| R-HSA-202424 | Downstream TCR signaling | 0.260482 | 0.584 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.094934 | 1.023 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.139879 | 0.854 |
| R-HSA-373753 | Nephrin family interactions | 0.221314 | 0.655 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.229073 | 0.640 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.301451 | 0.521 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.104385 | 0.981 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.050963 | 1.293 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.244361 | 0.612 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.138342 | 0.859 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.323214 | 0.491 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.329963 | 0.482 |
| R-HSA-111885 | Opioid Signalling | 0.319347 | 0.496 |
| R-HSA-3214847 | HATs acetylate histones | 0.301020 | 0.521 |
| R-HSA-2262752 | Cellular responses to stress | 0.057219 | 1.242 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.295534 | 0.529 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.067608 | 1.170 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.058676 | 1.232 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.145167 | 0.838 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.095108 | 1.022 |
| R-HSA-913531 | Interferon Signaling | 0.112145 | 0.950 |
| R-HSA-9824446 | Viral Infection Pathways | 0.258990 | 0.587 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.251892 | 0.599 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.173101 | 0.762 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.329963 | 0.482 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.245734 | 0.610 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.236979 | 0.625 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.213478 | 0.671 |
| R-HSA-168268 | Virus Assembly and Release | 0.181340 | 0.742 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.096058 | 1.017 |
| R-HSA-168256 | Immune System | 0.290476 | 0.537 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.325535 | 0.487 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.205563 | 0.687 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.310010 | 0.509 |
| R-HSA-157118 | Signaling by NOTCH | 0.263175 | 0.580 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.244361 | 0.612 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.242268 | 0.616 |
| R-HSA-69239 | Synthesis of DNA | 0.333929 | 0.476 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.336646 | 0.473 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.336646 | 0.473 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.336646 | 0.473 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.336646 | 0.473 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.336646 | 0.473 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.336646 | 0.473 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.336646 | 0.473 |
| R-HSA-190861 | Gap junction assembly | 0.336646 | 0.473 |
| R-HSA-5673000 | RAF activation | 0.336646 | 0.473 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.336646 | 0.473 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.337561 | 0.472 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.341187 | 0.467 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.341187 | 0.467 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.342277 | 0.466 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.343262 | 0.464 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.343262 | 0.464 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.343262 | 0.464 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.343262 | 0.464 |
| R-HSA-169911 | Regulation of Apoptosis | 0.343262 | 0.464 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.343262 | 0.464 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.343262 | 0.464 |
| R-HSA-202403 | TCR signaling | 0.344807 | 0.462 |
| R-HSA-5617833 | Cilium Assembly | 0.347718 | 0.459 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.349813 | 0.456 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.349813 | 0.456 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.349813 | 0.456 |
| R-HSA-111933 | Calmodulin induced events | 0.349813 | 0.456 |
| R-HSA-111997 | CaM pathway | 0.349813 | 0.456 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.349813 | 0.456 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.349813 | 0.456 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.350374 | 0.455 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.352028 | 0.453 |
| R-HSA-9679506 | SARS-CoV Infections | 0.354312 | 0.451 |
| R-HSA-68877 | Mitotic Prometaphase | 0.355870 | 0.449 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.356298 | 0.448 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.356298 | 0.448 |
| R-HSA-4641258 | Degradation of DVL | 0.356298 | 0.448 |
| R-HSA-4641257 | Degradation of AXIN | 0.356298 | 0.448 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.356298 | 0.448 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.356298 | 0.448 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.356298 | 0.448 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.356298 | 0.448 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.362720 | 0.440 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.362720 | 0.440 |
| R-HSA-1566948 | Elastic fibre formation | 0.362720 | 0.440 |
| R-HSA-9931953 | Biofilm formation | 0.362720 | 0.440 |
| R-HSA-8875878 | MET promotes cell motility | 0.362720 | 0.440 |
| R-HSA-112316 | Neuronal System | 0.364270 | 0.439 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.369078 | 0.433 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.369078 | 0.433 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.369078 | 0.433 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.369078 | 0.433 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.369078 | 0.433 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.369078 | 0.433 |
| R-HSA-69541 | Stabilization of p53 | 0.369078 | 0.433 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.369078 | 0.433 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.369958 | 0.432 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.374840 | 0.426 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.375372 | 0.426 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.375372 | 0.426 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.375372 | 0.426 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.375372 | 0.426 |
| R-HSA-9646399 | Aggrephagy | 0.375372 | 0.426 |
| R-HSA-8982491 | Glycogen metabolism | 0.375372 | 0.426 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.375372 | 0.426 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.375372 | 0.426 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.375372 | 0.426 |
| R-HSA-5260271 | Diseases of Immune System | 0.375372 | 0.426 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.375372 | 0.426 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.375372 | 0.426 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.375372 | 0.426 |
| R-HSA-70326 | Glucose metabolism | 0.377076 | 0.424 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.381605 | 0.418 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.381605 | 0.418 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.381605 | 0.418 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.381605 | 0.418 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.381605 | 0.418 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.381605 | 0.418 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.384161 | 0.415 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.384161 | 0.415 |
| R-HSA-1483257 | Phospholipid metabolism | 0.386527 | 0.413 |
| R-HSA-68875 | Mitotic Prophase | 0.387691 | 0.412 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.387775 | 0.411 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.387775 | 0.411 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.387775 | 0.411 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.387775 | 0.411 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.387775 | 0.411 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.387775 | 0.411 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.387775 | 0.411 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.391212 | 0.408 |
| R-HSA-3371556 | Cellular response to heat stress | 0.391212 | 0.408 |
| R-HSA-165159 | MTOR signalling | 0.393884 | 0.405 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.393884 | 0.405 |
| R-HSA-111996 | Ca-dependent events | 0.393884 | 0.405 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.394724 | 0.404 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.394724 | 0.404 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.398227 | 0.400 |
| R-HSA-9710421 | Defective pyroptosis | 0.399933 | 0.398 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.399933 | 0.398 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.399933 | 0.398 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.401721 | 0.396 |
| R-HSA-9907900 | Proteasome assembly | 0.405922 | 0.392 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.405922 | 0.392 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.405922 | 0.392 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.405922 | 0.392 |
| R-HSA-69236 | G1 Phase | 0.405922 | 0.392 |
| R-HSA-373752 | Netrin-1 signaling | 0.405922 | 0.392 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.405922 | 0.392 |
| R-HSA-156581 | Methylation | 0.405922 | 0.392 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.408679 | 0.389 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.408679 | 0.389 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.408679 | 0.389 |
| R-HSA-194138 | Signaling by VEGF | 0.408679 | 0.389 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.411851 | 0.385 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.411851 | 0.385 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.411851 | 0.385 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.411851 | 0.385 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.411851 | 0.385 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.411851 | 0.385 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.411851 | 0.385 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.411851 | 0.385 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.411851 | 0.385 |
| R-HSA-9824272 | Somitogenesis | 0.411851 | 0.385 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.411851 | 0.385 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.412419 | 0.385 |
| R-HSA-109582 | Hemostasis | 0.414368 | 0.383 |
| R-HSA-114608 | Platelet degranulation | 0.415599 | 0.381 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.417722 | 0.379 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.417722 | 0.379 |
| R-HSA-9675135 | Diseases of DNA repair | 0.417722 | 0.379 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.417722 | 0.379 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.417722 | 0.379 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.419044 | 0.378 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.423534 | 0.373 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.423534 | 0.373 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.423534 | 0.373 |
| R-HSA-5620924 | Intraflagellar transport | 0.429289 | 0.367 |
| R-HSA-70263 | Gluconeogenesis | 0.429289 | 0.367 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.429289 | 0.367 |
| R-HSA-425410 | Metal ion SLC transporters | 0.429289 | 0.367 |
| R-HSA-1474165 | Reproduction | 0.429316 | 0.367 |
| R-HSA-9843745 | Adipogenesis | 0.432719 | 0.364 |
| R-HSA-1500931 | Cell-Cell communication | 0.433570 | 0.363 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.434986 | 0.362 |
| R-HSA-9766229 | Degradation of CDH1 | 0.434986 | 0.362 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.434986 | 0.362 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.434986 | 0.362 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.434986 | 0.362 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.434986 | 0.362 |
| R-HSA-9909396 | Circadian clock | 0.436112 | 0.360 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.439493 | 0.357 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.440627 | 0.356 |
| R-HSA-912446 | Meiotic recombination | 0.446212 | 0.350 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.446212 | 0.350 |
| R-HSA-9864848 | Complex IV assembly | 0.446212 | 0.350 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.446212 | 0.350 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.446212 | 0.350 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.446212 | 0.350 |
| R-HSA-162906 | HIV Infection | 0.449285 | 0.347 |
| R-HSA-72187 | mRNA 3'-end processing | 0.451742 | 0.345 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.451742 | 0.345 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.452908 | 0.344 |
| R-HSA-5173105 | O-linked glycosylation | 0.456233 | 0.341 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.456233 | 0.341 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.457216 | 0.340 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.457216 | 0.340 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.457216 | 0.340 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.459547 | 0.338 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.459547 | 0.338 |
| R-HSA-72312 | rRNA processing | 0.462233 | 0.335 |
| R-HSA-72649 | Translation initiation complex formation | 0.462637 | 0.335 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.462637 | 0.335 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.462849 | 0.335 |
| R-HSA-1474244 | Extracellular matrix organization | 0.466591 | 0.331 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.468003 | 0.330 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.468003 | 0.330 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.469419 | 0.328 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.473317 | 0.325 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.473317 | 0.325 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.473317 | 0.325 |
| R-HSA-5578775 | Ion homeostasis | 0.473317 | 0.325 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.475940 | 0.322 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.478577 | 0.320 |
| R-HSA-5621480 | Dectin-2 family | 0.478577 | 0.320 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.478577 | 0.320 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.483786 | 0.315 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.483786 | 0.315 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.483786 | 0.315 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.483786 | 0.315 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.488942 | 0.311 |
| R-HSA-180786 | Extension of Telomeres | 0.488942 | 0.311 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.494048 | 0.306 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.494048 | 0.306 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.494048 | 0.306 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.494048 | 0.306 |
| R-HSA-156590 | Glutathione conjugation | 0.494048 | 0.306 |
| R-HSA-351202 | Metabolism of polyamines | 0.494048 | 0.306 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.494048 | 0.306 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.494048 | 0.306 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.494048 | 0.306 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.494048 | 0.306 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.494048 | 0.306 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.495212 | 0.305 |
| R-HSA-166520 | Signaling by NTRKs | 0.495212 | 0.305 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.499102 | 0.302 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.499102 | 0.302 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.499102 | 0.302 |
| R-HSA-112043 | PLC beta mediated events | 0.499102 | 0.302 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.499102 | 0.302 |
| R-HSA-450294 | MAP kinase activation | 0.499102 | 0.302 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.501536 | 0.300 |
| R-HSA-9707616 | Heme signaling | 0.504107 | 0.297 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.504107 | 0.297 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.504107 | 0.297 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.504679 | 0.297 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.507809 | 0.294 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.509062 | 0.293 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.509062 | 0.293 |
| R-HSA-8848021 | Signaling by PTK6 | 0.509062 | 0.293 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.509062 | 0.293 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.509062 | 0.293 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.509062 | 0.293 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.510927 | 0.292 |
| R-HSA-69306 | DNA Replication | 0.510927 | 0.292 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.513968 | 0.289 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.514032 | 0.289 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.517124 | 0.286 |
| R-HSA-1989781 | PPARA activates gene expression | 0.517124 | 0.286 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.518825 | 0.285 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.523268 | 0.281 |
| R-HSA-162587 | HIV Life Cycle | 0.523268 | 0.281 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.523633 | 0.281 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.523633 | 0.281 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.528394 | 0.277 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.528394 | 0.277 |
| R-HSA-112040 | G-protein mediated events | 0.528394 | 0.277 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.533108 | 0.273 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.533108 | 0.273 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.537775 | 0.269 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.537906 | 0.269 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.539281 | 0.268 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.542395 | 0.266 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.542395 | 0.266 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.542395 | 0.266 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.542395 | 0.266 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.542395 | 0.266 |
| R-HSA-448424 | Interleukin-17 signaling | 0.542395 | 0.266 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.544361 | 0.264 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.546970 | 0.262 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.546970 | 0.262 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.546970 | 0.262 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.546970 | 0.262 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.546970 | 0.262 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.551499 | 0.258 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.551499 | 0.258 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.551499 | 0.258 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.555983 | 0.255 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.555983 | 0.255 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.555983 | 0.255 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.560423 | 0.251 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.560423 | 0.251 |
| R-HSA-380287 | Centrosome maturation | 0.564818 | 0.248 |
| R-HSA-418555 | G alpha (s) signalling events | 0.567668 | 0.246 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.567668 | 0.246 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.569170 | 0.245 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.573360 | 0.242 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.573360 | 0.242 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.573479 | 0.241 |
| R-HSA-446728 | Cell junction organization | 0.574253 | 0.241 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.576185 | 0.239 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.577744 | 0.238 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.577744 | 0.238 |
| R-HSA-5619084 | ABC transporter disorders | 0.577744 | 0.238 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.578998 | 0.237 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.583300 | 0.234 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.586149 | 0.232 |
| R-HSA-9833482 | PKR-mediated signaling | 0.586149 | 0.232 |
| R-HSA-6806834 | Signaling by MET | 0.586149 | 0.232 |
| R-HSA-611105 | Respiratory electron transport | 0.587352 | 0.231 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.590289 | 0.229 |
| R-HSA-2559583 | Cellular Senescence | 0.592854 | 0.227 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.598445 | 0.223 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.601004 | 0.221 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.602463 | 0.220 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.602463 | 0.220 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.602463 | 0.220 |
| R-HSA-3781865 | Diseases of glycosylation | 0.603694 | 0.219 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.606440 | 0.217 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.610378 | 0.214 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.610378 | 0.214 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.618137 | 0.209 |
| R-HSA-70268 | Pyruvate metabolism | 0.618137 | 0.209 |
| R-HSA-195721 | Signaling by WNT | 0.618257 | 0.209 |
| R-HSA-597592 | Post-translational protein modification | 0.619214 | 0.208 |
| R-HSA-156902 | Peptide chain elongation | 0.621959 | 0.206 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.621959 | 0.206 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.622141 | 0.206 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.629488 | 0.201 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.629843 | 0.201 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.633197 | 0.198 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.634910 | 0.197 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.636869 | 0.196 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.640504 | 0.193 |
| R-HSA-391251 | Protein folding | 0.640504 | 0.193 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.640504 | 0.193 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.647667 | 0.189 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.647667 | 0.189 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.649787 | 0.187 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.651195 | 0.186 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.652220 | 0.186 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.654688 | 0.184 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.654688 | 0.184 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.654688 | 0.184 |
| R-HSA-1643685 | Disease | 0.655869 | 0.183 |
| R-HSA-72172 | mRNA Splicing | 0.657045 | 0.182 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.658146 | 0.182 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.658146 | 0.182 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.658146 | 0.182 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.658146 | 0.182 |
| R-HSA-157579 | Telomere Maintenance | 0.661569 | 0.179 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.661569 | 0.179 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.664959 | 0.177 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.664959 | 0.177 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.664959 | 0.177 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.664959 | 0.177 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.664959 | 0.177 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.668315 | 0.175 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.671637 | 0.173 |
| R-HSA-70171 | Glycolysis | 0.671637 | 0.173 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.671637 | 0.173 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.674926 | 0.171 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.674926 | 0.171 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.674926 | 0.171 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.678183 | 0.169 |
| R-HSA-192823 | Viral mRNA Translation | 0.681407 | 0.167 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.681407 | 0.167 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.684599 | 0.165 |
| R-HSA-9833110 | RSV-host interactions | 0.687759 | 0.163 |
| R-HSA-418990 | Adherens junctions interactions | 0.689343 | 0.162 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.690888 | 0.161 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.690888 | 0.161 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.693986 | 0.159 |
| R-HSA-8951664 | Neddylation | 0.695932 | 0.157 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.697053 | 0.157 |
| R-HSA-211000 | Gene Silencing by RNA | 0.697053 | 0.157 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.700089 | 0.155 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.700089 | 0.155 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.700089 | 0.155 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.702116 | 0.154 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.703095 | 0.153 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.703095 | 0.153 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.706071 | 0.151 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.706071 | 0.151 |
| R-HSA-6798695 | Neutrophil degranulation | 0.706686 | 0.151 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.711934 | 0.148 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.711934 | 0.148 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.714822 | 0.146 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.714822 | 0.146 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.717682 | 0.144 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.720512 | 0.142 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.723315 | 0.141 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.728836 | 0.137 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.728836 | 0.137 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.733085 | 0.135 |
| R-HSA-5693538 | Homology Directed Repair | 0.734248 | 0.134 |
| R-HSA-73894 | DNA Repair | 0.734456 | 0.134 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.736914 | 0.133 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.742166 | 0.129 |
| R-HSA-5663205 | Infectious disease | 0.742197 | 0.129 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.748329 | 0.126 |
| R-HSA-421270 | Cell-cell junction organization | 0.755669 | 0.122 |
| R-HSA-416476 | G alpha (q) signalling events | 0.778268 | 0.109 |
| R-HSA-163685 | Integration of energy metabolism | 0.784981 | 0.105 |
| R-HSA-5368287 | Mitochondrial translation | 0.789278 | 0.103 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.790819 | 0.102 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.794394 | 0.100 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.799653 | 0.097 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.803659 | 0.095 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.809519 | 0.092 |
| R-HSA-9758941 | Gastrulation | 0.813329 | 0.090 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.815205 | 0.089 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.818902 | 0.087 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.822243 | 0.085 |
| R-HSA-73887 | Death Receptor Signaling | 0.822526 | 0.085 |
| R-HSA-9610379 | HCMV Late Events | 0.827826 | 0.082 |
| R-HSA-5668914 | Diseases of metabolism | 0.828025 | 0.082 |
| R-HSA-9711097 | Cellular response to starvation | 0.829558 | 0.081 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.829558 | 0.081 |
| R-HSA-72766 | Translation | 0.830293 | 0.081 |
| R-HSA-877300 | Interferon gamma signaling | 0.831272 | 0.080 |
| R-HSA-109581 | Apoptosis | 0.836313 | 0.078 |
| R-HSA-5619102 | SLC transporter disorders | 0.844384 | 0.073 |
| R-HSA-72306 | tRNA processing | 0.850555 | 0.070 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.857530 | 0.067 |
| R-HSA-983712 | Ion channel transport | 0.876703 | 0.057 |
| R-HSA-382551 | Transport of small molecules | 0.878966 | 0.056 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.885222 | 0.053 |
| R-HSA-449147 | Signaling by Interleukins | 0.890207 | 0.051 |
| R-HSA-428157 | Sphingolipid metabolism | 0.890820 | 0.050 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.893011 | 0.049 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.893011 | 0.049 |
| R-HSA-5357801 | Programmed Cell Death | 0.896216 | 0.048 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.897892 | 0.047 |
| R-HSA-392499 | Metabolism of proteins | 0.902408 | 0.045 |
| R-HSA-388396 | GPCR downstream signalling | 0.903163 | 0.044 |
| R-HSA-211859 | Biological oxidations | 0.911527 | 0.040 |
| R-HSA-8939211 | ESR-mediated signaling | 0.924998 | 0.034 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.924998 | 0.034 |
| R-HSA-418594 | G alpha (i) signalling events | 0.929450 | 0.032 |
| R-HSA-168249 | Innate Immune System | 0.929658 | 0.032 |
| R-HSA-372790 | Signaling by GPCR | 0.942056 | 0.026 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.950578 | 0.022 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.984433 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.985059 | 0.007 |
| R-HSA-556833 | Metabolism of lipids | 0.986486 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 0.986926 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 0.998006 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.999846 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999970 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.855 | 0.481 | 1 | 0.870 |
CDK5 |
0.853 | 0.471 | 1 | 0.923 |
NLK |
0.852 | 0.443 | 1 | 0.933 |
CDK16 |
0.850 | 0.516 | 1 | 0.841 |
CDK19 |
0.848 | 0.418 | 1 | 0.884 |
CDK8 |
0.848 | 0.405 | 1 | 0.907 |
COT |
0.846 | 0.060 | 2 | 0.867 |
CDK17 |
0.846 | 0.459 | 1 | 0.828 |
KIS |
0.844 | 0.344 | 1 | 0.914 |
CDK7 |
0.844 | 0.394 | 1 | 0.913 |
HIPK4 |
0.843 | 0.279 | 1 | 0.946 |
CDKL5 |
0.843 | 0.201 | -3 | 0.748 |
ERK5 |
0.842 | 0.254 | 1 | 0.854 |
CDKL1 |
0.841 | 0.169 | -3 | 0.759 |
CDK14 |
0.840 | 0.473 | 1 | 0.889 |
CLK3 |
0.840 | 0.278 | 1 | 0.924 |
CDK1 |
0.838 | 0.420 | 1 | 0.875 |
SRPK1 |
0.838 | 0.199 | -3 | 0.691 |
MLK3 |
0.837 | 0.266 | 2 | 0.841 |
ULK2 |
0.837 | 0.031 | 2 | 0.797 |
IRE1 |
0.837 | 0.167 | 1 | 0.787 |
ERK1 |
0.837 | 0.440 | 1 | 0.862 |
NEK6 |
0.837 | 0.106 | -2 | 0.893 |
CDK3 |
0.836 | 0.414 | 1 | 0.841 |
P38A |
0.835 | 0.433 | 1 | 0.910 |
CDK13 |
0.835 | 0.377 | 1 | 0.896 |
IRE2 |
0.835 | 0.174 | 2 | 0.829 |
PKN3 |
0.834 | 0.119 | -3 | 0.764 |
PKCD |
0.834 | 0.182 | 2 | 0.871 |
P38G |
0.833 | 0.431 | 1 | 0.824 |
DSTYK |
0.833 | 0.044 | 2 | 0.883 |
ICK |
0.833 | 0.237 | -3 | 0.777 |
MTOR |
0.833 | 0.045 | 1 | 0.797 |
PRPK |
0.832 | -0.060 | -1 | 0.807 |
PRKD1 |
0.832 | 0.126 | -3 | 0.741 |
DYRK2 |
0.832 | 0.351 | 1 | 0.927 |
CDK9 |
0.831 | 0.382 | 1 | 0.898 |
PIM3 |
0.831 | 0.042 | -3 | 0.752 |
CDK10 |
0.831 | 0.437 | 1 | 0.885 |
MLK1 |
0.831 | 0.113 | 2 | 0.866 |
HIPK2 |
0.831 | 0.388 | 1 | 0.892 |
PKCA |
0.831 | 0.215 | 2 | 0.843 |
PKCB |
0.831 | 0.210 | 2 | 0.851 |
GCN2 |
0.830 | -0.110 | 2 | 0.797 |
WNK1 |
0.830 | 0.091 | -2 | 0.879 |
ERK2 |
0.830 | 0.411 | 1 | 0.898 |
P38B |
0.830 | 0.427 | 1 | 0.859 |
JNK2 |
0.830 | 0.417 | 1 | 0.864 |
MLK2 |
0.830 | 0.133 | 2 | 0.840 |
NEK7 |
0.829 | 0.015 | -3 | 0.848 |
SRPK2 |
0.829 | 0.152 | -3 | 0.622 |
HIPK1 |
0.829 | 0.368 | 1 | 0.936 |
CDK12 |
0.829 | 0.375 | 1 | 0.880 |
CDC7 |
0.829 | -0.081 | 1 | 0.738 |
CDK2 |
0.829 | 0.317 | 1 | 0.892 |
MST4 |
0.829 | 0.094 | 2 | 0.889 |
NUAK2 |
0.828 | 0.091 | -3 | 0.762 |
TGFBR2 |
0.828 | 0.027 | -2 | 0.821 |
ERK7 |
0.828 | 0.353 | 2 | 0.744 |
ATR |
0.828 | 0.015 | 1 | 0.788 |
MOS |
0.828 | -0.022 | 1 | 0.802 |
NIK |
0.827 | 0.101 | -3 | 0.823 |
NDR2 |
0.827 | 0.004 | -3 | 0.753 |
HIPK3 |
0.827 | 0.357 | 1 | 0.923 |
PKN2 |
0.827 | 0.109 | -3 | 0.767 |
CDK6 |
0.827 | 0.431 | 1 | 0.883 |
PKCZ |
0.827 | 0.175 | 2 | 0.859 |
DYRK1A |
0.827 | 0.321 | 1 | 0.943 |
PKCG |
0.826 | 0.176 | 2 | 0.841 |
PDHK4 |
0.826 | -0.198 | 1 | 0.798 |
NEK9 |
0.826 | 0.067 | 2 | 0.871 |
TBK1 |
0.826 | -0.095 | 1 | 0.649 |
JNK3 |
0.826 | 0.389 | 1 | 0.891 |
RAF1 |
0.825 | -0.113 | 1 | 0.749 |
NUAK1 |
0.825 | 0.075 | -3 | 0.721 |
BMPR2 |
0.825 | -0.134 | -2 | 0.924 |
P38D |
0.824 | 0.429 | 1 | 0.852 |
PDHK1 |
0.824 | -0.135 | 1 | 0.772 |
RIPK3 |
0.824 | -0.015 | 3 | 0.762 |
ULK1 |
0.824 | -0.058 | -3 | 0.822 |
PRKD2 |
0.824 | 0.072 | -3 | 0.689 |
PIM1 |
0.823 | 0.079 | -3 | 0.700 |
CHAK2 |
0.823 | 0.008 | -1 | 0.815 |
CAMK1B |
0.823 | -0.036 | -3 | 0.808 |
MARK4 |
0.822 | -0.026 | 4 | 0.707 |
PHKG1 |
0.822 | 0.106 | -3 | 0.740 |
P90RSK |
0.821 | 0.046 | -3 | 0.711 |
NDR1 |
0.821 | -0.024 | -3 | 0.751 |
AMPKA1 |
0.820 | 0.000 | -3 | 0.773 |
PKCH |
0.820 | 0.152 | 2 | 0.820 |
IKKE |
0.820 | -0.138 | 1 | 0.648 |
WNK3 |
0.819 | -0.120 | 1 | 0.770 |
MLK4 |
0.819 | 0.129 | 2 | 0.805 |
PRKD3 |
0.819 | 0.082 | -3 | 0.678 |
SRPK3 |
0.819 | 0.112 | -3 | 0.681 |
MELK |
0.818 | 0.037 | -3 | 0.731 |
CDK4 |
0.818 | 0.404 | 1 | 0.875 |
NEK2 |
0.818 | 0.106 | 2 | 0.865 |
IRAK4 |
0.817 | 0.132 | 1 | 0.774 |
RSK3 |
0.817 | 0.010 | -3 | 0.703 |
TSSK1 |
0.817 | 0.058 | -3 | 0.785 |
AMPKA2 |
0.817 | 0.017 | -3 | 0.740 |
RSK2 |
0.817 | 0.027 | -3 | 0.703 |
PKR |
0.817 | 0.106 | 1 | 0.812 |
CLK1 |
0.817 | 0.194 | -3 | 0.674 |
CAMK2G |
0.816 | -0.148 | 2 | 0.770 |
IKKB |
0.816 | -0.207 | -2 | 0.800 |
NIM1 |
0.816 | -0.046 | 3 | 0.765 |
CAMLCK |
0.816 | -0.046 | -2 | 0.847 |
CHAK1 |
0.815 | 0.047 | 2 | 0.778 |
TSSK2 |
0.815 | 0.047 | -5 | 0.837 |
ANKRD3 |
0.815 | -0.025 | 1 | 0.786 |
DYRK1B |
0.815 | 0.325 | 1 | 0.909 |
LATS2 |
0.815 | -0.027 | -5 | 0.706 |
QIK |
0.814 | -0.012 | -3 | 0.781 |
BCKDK |
0.814 | -0.163 | -1 | 0.732 |
PRP4 |
0.813 | 0.212 | -3 | 0.716 |
MAPKAPK3 |
0.813 | -0.021 | -3 | 0.695 |
SKMLCK |
0.813 | -0.051 | -2 | 0.844 |
DAPK2 |
0.813 | -0.055 | -3 | 0.814 |
PKCT |
0.813 | 0.135 | 2 | 0.827 |
MASTL |
0.813 | -0.162 | -2 | 0.875 |
HUNK |
0.813 | -0.135 | 2 | 0.753 |
MNK2 |
0.812 | 0.009 | -2 | 0.769 |
CAMK2D |
0.812 | -0.058 | -3 | 0.782 |
MNK1 |
0.812 | 0.054 | -2 | 0.785 |
GRK5 |
0.811 | -0.187 | -3 | 0.805 |
PINK1 |
0.811 | 0.093 | 1 | 0.902 |
CLK4 |
0.811 | 0.145 | -3 | 0.696 |
MPSK1 |
0.811 | 0.162 | 1 | 0.804 |
YSK4 |
0.810 | 0.019 | 1 | 0.699 |
DYRK3 |
0.810 | 0.247 | 1 | 0.932 |
P70S6KB |
0.809 | -0.034 | -3 | 0.736 |
QSK |
0.809 | -0.016 | 4 | 0.701 |
RIPK1 |
0.809 | -0.150 | 1 | 0.767 |
PIM2 |
0.809 | 0.074 | -3 | 0.686 |
TTBK2 |
0.809 | -0.129 | 2 | 0.728 |
SIK |
0.809 | -0.011 | -3 | 0.697 |
PKCI |
0.809 | 0.150 | 2 | 0.852 |
DYRK4 |
0.809 | 0.319 | 1 | 0.890 |
IKKA |
0.808 | -0.119 | -2 | 0.800 |
VRK2 |
0.807 | -0.004 | 1 | 0.847 |
MAK |
0.807 | 0.321 | -2 | 0.802 |
LATS1 |
0.807 | 0.038 | -3 | 0.756 |
HRI |
0.807 | -0.007 | -2 | 0.888 |
PERK |
0.807 | 0.001 | -2 | 0.879 |
MOK |
0.806 | 0.298 | 1 | 0.913 |
NEK5 |
0.806 | 0.085 | 1 | 0.784 |
AURC |
0.805 | -0.009 | -2 | 0.606 |
PKCE |
0.805 | 0.174 | 2 | 0.836 |
PAK3 |
0.805 | -0.079 | -2 | 0.768 |
CHK1 |
0.804 | 0.029 | -3 | 0.743 |
PHKG2 |
0.804 | 0.054 | -3 | 0.724 |
WNK4 |
0.803 | -0.001 | -2 | 0.884 |
PKACG |
0.803 | -0.071 | -2 | 0.722 |
MST3 |
0.803 | 0.154 | 2 | 0.881 |
CAMK4 |
0.803 | -0.098 | -3 | 0.744 |
DLK |
0.803 | -0.210 | 1 | 0.751 |
ATM |
0.802 | -0.089 | 1 | 0.720 |
ZAK |
0.801 | 0.018 | 1 | 0.706 |
MARK3 |
0.801 | -0.039 | 4 | 0.656 |
MEKK1 |
0.801 | -0.027 | 1 | 0.755 |
PKN1 |
0.801 | 0.112 | -3 | 0.663 |
FAM20C |
0.801 | -0.036 | 2 | 0.545 |
MAPKAPK2 |
0.801 | -0.034 | -3 | 0.644 |
PAK1 |
0.801 | -0.073 | -2 | 0.767 |
SMG1 |
0.801 | -0.075 | 1 | 0.751 |
SGK3 |
0.800 | 0.011 | -3 | 0.682 |
BRSK2 |
0.800 | -0.078 | -3 | 0.741 |
ALK4 |
0.800 | -0.079 | -2 | 0.857 |
CAMK1G |
0.800 | -0.010 | -3 | 0.708 |
GRK1 |
0.800 | -0.095 | -2 | 0.827 |
MEKK2 |
0.799 | 0.026 | 2 | 0.819 |
AKT2 |
0.799 | 0.028 | -3 | 0.626 |
PAK6 |
0.799 | -0.027 | -2 | 0.678 |
PKG2 |
0.799 | -0.014 | -2 | 0.634 |
MARK2 |
0.799 | -0.067 | 4 | 0.611 |
RSK4 |
0.799 | 0.010 | -3 | 0.667 |
PLK1 |
0.798 | -0.129 | -2 | 0.855 |
AURB |
0.797 | -0.038 | -2 | 0.610 |
MSK2 |
0.797 | -0.075 | -3 | 0.680 |
MEK5 |
0.797 | -0.079 | 2 | 0.805 |
CLK2 |
0.797 | 0.149 | -3 | 0.666 |
NEK8 |
0.797 | 0.062 | 2 | 0.861 |
JNK1 |
0.797 | 0.315 | 1 | 0.853 |
NEK4 |
0.796 | 0.089 | 1 | 0.738 |
MEK1 |
0.796 | -0.212 | 2 | 0.778 |
SNRK |
0.796 | -0.152 | 2 | 0.652 |
PLK4 |
0.795 | -0.099 | 2 | 0.586 |
DNAPK |
0.795 | -0.047 | 1 | 0.668 |
BRSK1 |
0.795 | -0.090 | -3 | 0.716 |
CAMK2A |
0.794 | -0.057 | 2 | 0.739 |
BUB1 |
0.794 | 0.206 | -5 | 0.838 |
MARK1 |
0.794 | -0.082 | 4 | 0.682 |
GRK6 |
0.794 | -0.235 | 1 | 0.723 |
DCAMKL1 |
0.793 | -0.038 | -3 | 0.687 |
BRAF |
0.793 | -0.090 | -4 | 0.817 |
TGFBR1 |
0.793 | -0.092 | -2 | 0.828 |
TAO2 |
0.793 | 0.063 | 2 | 0.894 |
PAK2 |
0.793 | -0.113 | -2 | 0.755 |
TAO3 |
0.793 | 0.019 | 1 | 0.747 |
GRK4 |
0.792 | -0.259 | -2 | 0.867 |
BMPR1B |
0.792 | -0.059 | 1 | 0.666 |
SSTK |
0.792 | -0.031 | 4 | 0.712 |
MYLK4 |
0.792 | -0.072 | -2 | 0.738 |
CAMK2B |
0.792 | -0.103 | 2 | 0.716 |
MEKK6 |
0.791 | 0.081 | 1 | 0.752 |
HGK |
0.791 | 0.089 | 3 | 0.811 |
AKT1 |
0.791 | 0.023 | -3 | 0.631 |
TLK2 |
0.791 | -0.162 | 1 | 0.770 |
EEF2K |
0.790 | 0.108 | 3 | 0.770 |
NEK11 |
0.790 | -0.015 | 1 | 0.723 |
PKACB |
0.790 | -0.029 | -2 | 0.627 |
MAPKAPK5 |
0.789 | -0.116 | -3 | 0.669 |
ACVR2A |
0.789 | -0.103 | -2 | 0.824 |
NEK1 |
0.789 | 0.106 | 1 | 0.754 |
MEKK3 |
0.789 | -0.143 | 1 | 0.733 |
TNIK |
0.789 | 0.096 | 3 | 0.795 |
LOK |
0.789 | 0.070 | -2 | 0.809 |
SMMLCK |
0.788 | -0.041 | -3 | 0.768 |
LRRK2 |
0.788 | 0.081 | 2 | 0.867 |
PLK3 |
0.787 | -0.151 | 2 | 0.703 |
IRAK1 |
0.787 | -0.159 | -1 | 0.711 |
DCAMKL2 |
0.787 | -0.046 | -3 | 0.725 |
DRAK1 |
0.787 | -0.114 | 1 | 0.650 |
LKB1 |
0.787 | -0.041 | -3 | 0.802 |
MINK |
0.786 | 0.051 | 1 | 0.720 |
TTBK1 |
0.786 | -0.125 | 2 | 0.645 |
ACVR2B |
0.786 | -0.128 | -2 | 0.838 |
P70S6K |
0.786 | -0.050 | -3 | 0.661 |
MAP3K15 |
0.786 | 0.042 | 1 | 0.708 |
GSK3A |
0.785 | 0.024 | 4 | 0.296 |
ALK2 |
0.785 | -0.121 | -2 | 0.838 |
NEK3 |
0.785 | 0.035 | 1 | 0.731 |
TLK1 |
0.785 | -0.162 | -2 | 0.856 |
GRK7 |
0.784 | -0.092 | 1 | 0.688 |
MSK1 |
0.784 | -0.077 | -3 | 0.683 |
YSK1 |
0.784 | 0.108 | 2 | 0.874 |
CAMKK1 |
0.784 | -0.120 | -2 | 0.805 |
CK1E |
0.784 | -0.073 | -3 | 0.468 |
GCK |
0.783 | 0.023 | 1 | 0.727 |
MST2 |
0.783 | -0.028 | 1 | 0.722 |
KHS1 |
0.783 | 0.083 | 1 | 0.713 |
PDK1 |
0.782 | -0.064 | 1 | 0.748 |
GAK |
0.782 | -0.015 | 1 | 0.796 |
PRKX |
0.782 | -0.022 | -3 | 0.584 |
AKT3 |
0.781 | 0.025 | -3 | 0.553 |
MST1 |
0.780 | 0.008 | 1 | 0.716 |
CAMK1D |
0.780 | -0.038 | -3 | 0.610 |
GRK2 |
0.779 | -0.135 | -2 | 0.751 |
GSK3B |
0.779 | -0.066 | 4 | 0.288 |
KHS2 |
0.779 | 0.080 | 1 | 0.725 |
VRK1 |
0.779 | -0.071 | 2 | 0.843 |
PBK |
0.779 | 0.017 | 1 | 0.740 |
SLK |
0.778 | 0.009 | -2 | 0.765 |
CAMK1A |
0.778 | 0.010 | -3 | 0.584 |
ROCK2 |
0.777 | 0.024 | -3 | 0.700 |
CHK2 |
0.777 | 0.010 | -3 | 0.562 |
MYO3B |
0.777 | 0.144 | 2 | 0.884 |
PASK |
0.777 | -0.073 | -3 | 0.776 |
TTK |
0.776 | 0.089 | -2 | 0.854 |
CAMKK2 |
0.776 | -0.146 | -2 | 0.803 |
PAK5 |
0.776 | -0.090 | -2 | 0.620 |
MRCKB |
0.775 | -0.006 | -3 | 0.675 |
TAK1 |
0.775 | -0.066 | 1 | 0.753 |
HPK1 |
0.775 | -0.012 | 1 | 0.706 |
AURA |
0.773 | -0.103 | -2 | 0.580 |
HASPIN |
0.773 | 0.040 | -1 | 0.649 |
CK1G1 |
0.772 | -0.116 | -3 | 0.462 |
PKACA |
0.772 | -0.053 | -2 | 0.569 |
STK33 |
0.772 | -0.102 | 2 | 0.602 |
CK1D |
0.772 | -0.078 | -3 | 0.419 |
MRCKA |
0.772 | -0.017 | -3 | 0.679 |
BMPR1A |
0.772 | -0.098 | 1 | 0.645 |
SGK1 |
0.771 | 0.000 | -3 | 0.542 |
DAPK3 |
0.771 | -0.071 | -3 | 0.720 |
DMPK1 |
0.771 | 0.048 | -3 | 0.677 |
PAK4 |
0.771 | -0.089 | -2 | 0.623 |
MYO3A |
0.769 | 0.100 | 1 | 0.749 |
RIPK2 |
0.769 | -0.170 | 1 | 0.662 |
SBK |
0.769 | 0.033 | -3 | 0.507 |
MEK2 |
0.769 | -0.175 | 2 | 0.767 |
BIKE |
0.768 | 0.044 | 1 | 0.690 |
ROCK1 |
0.766 | 0.008 | -3 | 0.677 |
TAO1 |
0.765 | 0.023 | 1 | 0.685 |
LIMK2_TYR |
0.764 | 0.185 | -3 | 0.835 |
CK1A2 |
0.764 | -0.103 | -3 | 0.418 |
TESK1_TYR |
0.762 | 0.103 | 3 | 0.829 |
PDHK3_TYR |
0.762 | 0.068 | 4 | 0.762 |
OSR1 |
0.761 | -0.037 | 2 | 0.802 |
PKMYT1_TYR |
0.761 | 0.113 | 3 | 0.815 |
PKG1 |
0.760 | -0.070 | -2 | 0.545 |
AAK1 |
0.759 | 0.092 | 1 | 0.611 |
GRK3 |
0.759 | -0.150 | -2 | 0.700 |
TNNI3K_TYR |
0.759 | 0.172 | 1 | 0.766 |
DAPK1 |
0.758 | -0.102 | -3 | 0.714 |
ASK1 |
0.758 | -0.043 | 1 | 0.689 |
ROS1 |
0.757 | 0.094 | 3 | 0.800 |
LIMK1_TYR |
0.757 | 0.078 | 2 | 0.851 |
CRIK |
0.756 | -0.019 | -3 | 0.630 |
PLK2 |
0.756 | -0.118 | -3 | 0.761 |
TYK2 |
0.756 | 0.046 | 1 | 0.747 |
JAK2 |
0.753 | 0.033 | 1 | 0.747 |
MAP2K7_TYR |
0.753 | -0.129 | 2 | 0.813 |
JAK1 |
0.752 | 0.128 | 1 | 0.683 |
RET |
0.751 | -0.030 | 1 | 0.757 |
TYRO3 |
0.751 | -0.015 | 3 | 0.811 |
PINK1_TYR |
0.751 | -0.084 | 1 | 0.797 |
PDHK4_TYR |
0.751 | -0.071 | 2 | 0.811 |
TNK1 |
0.750 | 0.066 | 3 | 0.781 |
MST1R |
0.750 | -0.027 | 3 | 0.809 |
MAP2K4_TYR |
0.750 | -0.165 | -1 | 0.807 |
CSF1R |
0.749 | -0.000 | 3 | 0.805 |
CK2A2 |
0.749 | -0.148 | 1 | 0.591 |
MAP2K6_TYR |
0.747 | -0.159 | -1 | 0.806 |
EPHA6 |
0.746 | -0.038 | -1 | 0.754 |
TNK2 |
0.745 | 0.012 | 3 | 0.781 |
BMPR2_TYR |
0.745 | -0.125 | -1 | 0.765 |
FGR |
0.744 | -0.020 | 1 | 0.747 |
PDGFRB |
0.743 | -0.043 | 3 | 0.820 |
PDHK1_TYR |
0.743 | -0.180 | -1 | 0.807 |
YES1 |
0.743 | -0.030 | -1 | 0.797 |
LCK |
0.743 | 0.017 | -1 | 0.754 |
EPHB4 |
0.742 | -0.065 | -1 | 0.739 |
KDR |
0.742 | 0.017 | 3 | 0.779 |
JAK3 |
0.741 | -0.075 | 1 | 0.735 |
DDR1 |
0.741 | -0.125 | 4 | 0.698 |
TEK |
0.741 | -0.016 | 3 | 0.776 |
HCK |
0.741 | -0.038 | -1 | 0.752 |
WEE1_TYR |
0.741 | 0.037 | -1 | 0.693 |
ABL2 |
0.741 | -0.062 | -1 | 0.731 |
FLT3 |
0.740 | -0.042 | 3 | 0.804 |
PDGFRA |
0.740 | -0.046 | 3 | 0.815 |
NEK10_TYR |
0.739 | -0.039 | 1 | 0.670 |
ABL1 |
0.739 | -0.060 | -1 | 0.731 |
YANK3 |
0.739 | -0.090 | 2 | 0.396 |
ALPHAK3 |
0.738 | -0.164 | -1 | 0.699 |
STLK3 |
0.738 | -0.195 | 1 | 0.680 |
INSRR |
0.738 | -0.084 | 3 | 0.779 |
CK2A1 |
0.737 | -0.163 | 1 | 0.569 |
FGFR1 |
0.737 | -0.050 | 3 | 0.794 |
ALK |
0.736 | -0.031 | 3 | 0.757 |
BLK |
0.736 | -0.007 | -1 | 0.747 |
FER |
0.735 | -0.146 | 1 | 0.746 |
FGFR2 |
0.735 | -0.091 | 3 | 0.800 |
KIT |
0.734 | -0.105 | 3 | 0.809 |
TXK |
0.734 | -0.062 | 1 | 0.699 |
AXL |
0.733 | -0.092 | 3 | 0.804 |
ITK |
0.733 | -0.090 | -1 | 0.722 |
LTK |
0.730 | -0.074 | 3 | 0.763 |
EPHB1 |
0.730 | -0.125 | 1 | 0.709 |
DDR2 |
0.729 | -0.006 | 3 | 0.765 |
BTK |
0.729 | -0.146 | -1 | 0.702 |
EPHB3 |
0.728 | -0.127 | -1 | 0.723 |
SRMS |
0.728 | -0.162 | 1 | 0.711 |
PTK6 |
0.728 | -0.150 | -1 | 0.690 |
TEC |
0.728 | -0.089 | -1 | 0.667 |
MERTK |
0.728 | -0.115 | 3 | 0.785 |
NTRK2 |
0.727 | -0.123 | 3 | 0.790 |
EPHA1 |
0.727 | -0.075 | 3 | 0.787 |
EPHA4 |
0.726 | -0.128 | 2 | 0.695 |
INSR |
0.726 | -0.101 | 3 | 0.748 |
MET |
0.726 | -0.123 | 3 | 0.793 |
EPHB2 |
0.725 | -0.131 | -1 | 0.709 |
LYN |
0.724 | -0.084 | 3 | 0.728 |
BMX |
0.723 | -0.111 | -1 | 0.630 |
CK1A |
0.723 | -0.141 | -3 | 0.328 |
FRK |
0.722 | -0.101 | -1 | 0.741 |
FLT4 |
0.721 | -0.136 | 3 | 0.765 |
FYN |
0.721 | -0.069 | -1 | 0.733 |
EPHA7 |
0.721 | -0.105 | 2 | 0.718 |
FGFR3 |
0.721 | -0.131 | 3 | 0.781 |
NTRK1 |
0.720 | -0.203 | -1 | 0.742 |
ERBB2 |
0.719 | -0.169 | 1 | 0.679 |
NTRK3 |
0.719 | -0.129 | -1 | 0.701 |
MATK |
0.719 | -0.104 | -1 | 0.657 |
FLT1 |
0.718 | -0.147 | -1 | 0.726 |
MUSK |
0.716 | -0.067 | 1 | 0.591 |
EPHA3 |
0.715 | -0.170 | 2 | 0.683 |
PTK2B |
0.715 | -0.097 | -1 | 0.720 |
SRC |
0.714 | -0.108 | -1 | 0.740 |
YANK2 |
0.709 | -0.106 | 2 | 0.413 |
CSK |
0.707 | -0.166 | 2 | 0.718 |
EPHA5 |
0.706 | -0.168 | 2 | 0.677 |
EPHA8 |
0.706 | -0.152 | -1 | 0.690 |
EGFR |
0.705 | -0.139 | 1 | 0.583 |
CK1G3 |
0.704 | -0.149 | -3 | 0.285 |
IGF1R |
0.703 | -0.164 | 3 | 0.698 |
FGFR4 |
0.702 | -0.161 | -1 | 0.685 |
PTK2 |
0.698 | -0.116 | -1 | 0.672 |
EPHA2 |
0.696 | -0.161 | -1 | 0.649 |
FES |
0.690 | -0.158 | -1 | 0.627 |
SYK |
0.690 | -0.162 | -1 | 0.661 |
ERBB4 |
0.689 | -0.146 | 1 | 0.575 |
CK1G2 |
0.676 | -0.163 | -3 | 0.380 |
ZAP70 |
0.675 | -0.132 | -1 | 0.591 |