Motif 977 (n=204)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S527 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A8CG34 | POM121C | S348 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00287 | RFXAP | S193 | ochoa | Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) | Part of the RFX complex that binds to the X-box of MHC II promoters. |
| O00522 | KRIT1 | S22 | ochoa | Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067). {ECO:0000250|UniProtKB:Q6S5J6, ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:20616044, ECO:0000269|PubMed:20668652, ECO:0000269|PubMed:21633110, ECO:0000269|PubMed:23317506, ECO:0000269|PubMed:26417067}. |
| O14617 | AP3D1 | S1071 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O60610 | DIAPH1 | S154 | psp | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| O60825 | PFKFB2 | S32 | psp | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}. |
| O75143 | ATG13 | S478 | ochoa | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O94885 | SASH1 | S731 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94967 | WDR47 | S183 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95071 | UBR5 | S2586 | psp | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95359 | TACC2 | S2533 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O96018 | APBA3 | S46 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) | May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}. |
| P02144 | MB | S59 | ochoa | Myoglobin (Nitrite reductase MB) (EC 1.7.-.-) (Pseudoperoxidase MB) (EC 1.11.1.-) | Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218). {ECO:0000269|PubMed:30918256, ECO:0000269|PubMed:32891753, ECO:0000269|PubMed:34679218}. |
| P02545 | LMNA | S573 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02730 | SLC4A1 | S50 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P04083 | ANXA1 | S37 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04233 | CD74 | S45 | psp | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}. |
| P05107 | ITGB2 | S349 | ochoa | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}. |
| P07900 | HSP90AA1 | S50 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07910 | HNRNPC | S253 | ochoa|psp | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P07949 | RET | S909 | psp | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P08195 | SLC3A2 | S129 | ochoa | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P08238 | HSP90AB1 | S45 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09467 | FBP1 | S63 | psp | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P10155 | RO60 | S19 | ochoa | RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) | RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853). Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). May play roles in cilia formation and/or maintenance (By similarity). {ECO:0000250|UniProtKB:O08848, ECO:0000269|PubMed:18056422, ECO:0000269|PubMed:26382853}. |
| P10809 | HSPD1 | S232 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11277 | SPTB | S2060 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P14625 | HSP90B1 | S106 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P16083 | NQO2 | S83 | ochoa | Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) | The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}. |
| P16144 | ITGB4 | S1212 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16234 | PDGFRA | S767 | ochoa|psp | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| P18031 | PTPN1 | S365 | ochoa | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18206 | VCL | S434 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20700 | LMNB1 | S279 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P21796 | VDAC1 | S44 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P21860 | ERBB3 | S844 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P26358 | DNMT1 | S35 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P30086 | PEBP1 | S52 | ochoa|psp | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P30530 | AXL | S635 | ochoa | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| P30740 | SERPINB1 | S72 | ochoa | Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). {ECO:0000269|PubMed:11747453, ECO:0000269|PubMed:23269243, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}. |
| P31751 | AKT2 | S447 | ochoa | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta) | Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through the phosphorylation of a range of downstream substrates. Over 100 substrates have been reported so far, although for most of them, the precise AKT kinase catalyzing the reaction was not specified. AKT regulates glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1). AKT mediates the antiapoptotic effects of IGF1. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development (PubMed:21432781, PubMed:21620960). In response to lysophosphatidic acid stimulation, inhibits the ciliogenesis cascade. In this context, phosphorylates WDR44, hence stabilizing its interaction with Rab11 and preventing the formation of the ciliogenic Rab11-FIP3-RAB3IP complex. Also phosphorylates RAB3IP/Rabin8, thus may affect RAB3IP guanine nucleotide exchange factor (GEF) activity toward Rab8, which is important for cilia growth (PubMed:31204173). Phosphorylates PKP1, facilitating its interaction with YWHAG and translocation to the nucleus, ultimately resulting in a reduction in keratinocyte intercellular adhesion (By similarity). Phosphorylation of PKP1 increases PKP1 protein stability, translocation to the cytoplasm away from desmosome plaques and PKP1-driven cap-dependent translation (PubMed:23444369). {ECO:0000250|UniProtKB:Q60823, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:31204173, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.; FUNCTION: Several AKT2-specific substrates have been identified, including ANKRD2, C2CD5, CLK2 and PITX2. May play a role in myoblast differentiation. In this context, may act through PITX2 phosphorylation. Unphosphorylated PITX2 associates with an ELAVL1/HuR-containing complex, which stabilizes CCND1 cyclin mRNA, ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation (By similarity). Also involved in the negative regulation of myogenesis in response to stress conditions. In this context, acts by phosphorylating ANKRD2 (By similarity). May also be a key regulator of glucose uptake. Regulates insulin-stimulated glucose transport by the increase of glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. In this context, acts by phosphorylating C2CD5/CDP138 on 'Ser-197' in insulin-stimulated adipocytes (By similarity). Through the phosphorylation of CLK2 on 'Thr-343', involved in insulin-regulated suppression of hepatic gluconeogenesis (By similarity). {ECO:0000250|UniProtKB:Q60823}. |
| P34910 | EVI2B | S268 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35520 | CBS | S227 | psp | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}. |
| P35579 | MYH9 | S364 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P42858 | HTT | S464 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P43307 | SSR1 | S247 | ochoa | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. |
| P46100 | ATRX | S750 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S890 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S1764 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48634 | PRRC2A | S204 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48681 | NES | S1590 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49411 | TUFM | S222 | psp | Elongation factor Tu, mitochondrial (EF-Tu) (EC 3.6.5.3) (P43) | GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. {ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:28407488}. |
| P49796 | RGS3 | S917 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P49815 | TSC2 | S1338 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P49959 | MRE11 | S531 | psp | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P50990 | CCT8 | S150 | ochoa | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51116 | FXR2 | S192 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P53814 | SMTN | S139 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P53990 | IST1 | S181 | ochoa | IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) | ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| P54198 | HIRA | S584 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P54284 | CACNB3 | S422 | ochoa | Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) | Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). {ECO:0000250|UniProtKB:P54287, ECO:0000250|UniProtKB:Q9MZL3, ECO:0000269|PubMed:8119293}. |
| P55196 | AFDN | S1510 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56945 | BCAR1 | S440 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P60484 | PTEN | S302 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P62333 | PSMC6 | S131 | ochoa | 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P62820 | RAB1A | S114 | ochoa | Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Regulates the level of CASR present at the cell membrane (PubMed:20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). {ECO:0000250|UniProtKB:P62821, ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:26209634}. |
| P62826 | RAN | S150 | ochoa | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) | GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:11336674, PubMed:26272610, PubMed:29040603, PubMed:7819259, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:12194828, PubMed:29040603, PubMed:8421051). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640). {ECO:0000269|PubMed:10400640, ECO:0000269|PubMed:10408446, ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:7819259, ECO:0000269|PubMed:8276887, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8636225, ECO:0000269|PubMed:8692944, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9428644, ECO:0000269|PubMed:9822603, ECO:0000305|PubMed:26272610}. |
| P78559 | MAP1A | S1196 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q01082 | SPTBN1 | S768 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01970 | PLCB3 | S1107 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q03135 | CAV1 | S37 | ochoa | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| Q05682 | CALD1 | S724 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q07157 | TJP1 | S1366 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08050 | FOXM1 | S306 | psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q12802 | AKAP13 | S1363 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12802 | AKAP13 | S1408 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13136 | PPFIA1 | S596 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13144 | EIF2B5 | S544 | ochoa|psp | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q13151 | HNRNPA0 | S19 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13416 | ORC2 | S145 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13422 | IKZF1 | S361 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13433 | SLC39A6 | S498 | ochoa | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q8C145, ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:18272141, ECO:0000269|PubMed:21422171, ECO:0000269|PubMed:23919497, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30552163, ECO:0000269|PubMed:32797246, ECO:0000269|PubMed:34394081}. |
| Q13813 | SPTAN1 | S2139 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14151 | SAFB2 | S274 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14315 | FLNC | S339 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14562 | DHX8 | S377 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q14568 | HSP90AA2P | S50 | ochoa | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q14761 | PTPRCAP | S163 | ochoa|psp | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
| Q14BN4 | SLMAP | S458 | ochoa | Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) | Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}. |
| Q15306 | IRF4 | Y62 | psp | Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5) | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. {ECO:0000269|PubMed:29537367, ECO:0000269|PubMed:36662884, ECO:0000269|PubMed:36917008}. |
| Q15398 | DLGAP5 | S777 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15424 | SAFB | S275 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15746 | MYLK | S1570 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q15751 | HERC1 | S1541 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q16513 | PKN2 | S603 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16659 | MAPK6 | S676 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q27J81 | INF2 | S1083 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2LD37 | BLTP1 | S3562 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2TBE0 | CWF19L2 | S474 | ochoa | CWF19-like protein 2 | None |
| Q52LW3 | ARHGAP29 | S492 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5CZC0 | FSIP2 | S3898 | ochoa | Fibrous sheath-interacting protein 2 | Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}. |
| Q5JSH3 | WDR44 | S96 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5PRF9 | SAMD4B | S299 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5QJE6 | DNTTIP2 | S474 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5VT25 | CDC42BPA | S940 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q641Q2 | WASHC2A | S552 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q66K14 | TBC1D9B | S442 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6P4F7 | ARHGAP11A | S582 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P9F7 | LRRC8B | S192 | ochoa | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}. |
| Q6UX04 | CWC27 | S266 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q7KZ85 | SUPT6H | S280 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7Z6E9 | RBBP6 | S960 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6Z7 | HUWE1 | S3258 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86U86 | PBRM1 | S375 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UP2 | KTN1 | S1325 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86UR5 | RIMS1 | S1496 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86W56 | PARG | S197 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q86W92 | PPFIBP1 | S936 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8IW35 | CEP97 | S762 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IXI1 | RHOT2 | S331 | ochoa | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8IZD2 | KMT2E | S843 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8N0S6 | CENPL | S53 | ochoa | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16716197}. |
| Q8N565 | MREG | S38 | ochoa | Melanoregulin (Dilute suppressor protein homolog) | Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). {ECO:0000250|UniProtKB:Q6NVG5, ECO:0000269|PubMed:19240024}. |
| Q8NEM2 | SHCBP1 | S574 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NFG4 | FLCN | S406 | psp | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
| Q8NHV4 | NEDD1 | S586 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TB72 | PUM2 | S93 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8TC05 | MDM1 | S686 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TDB6 | DTX3L | S539 | ochoa | E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}. |
| Q8TDJ6 | DMXL2 | S1140 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TF62 | ATP8B4 | S728 | ochoa | Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) | Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}. |
| Q8WVC0 | LEO1 | S608 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WVM8 | SCFD1 | S384 | ochoa | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q96CW1 | AP2M1 | S240 | ochoa | AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) | Component of the adaptor protein complex 2 (AP-2) (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:16581796). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (PubMed:19033387). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:11877457). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (PubMed:11877457). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P84092, ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:12694563, ECO:0000269|PubMed:12952941, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:16581796, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:31104773}. |
| Q96IQ7 | VSIG2 | S293 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96LD4 | TRIM47 | S399 | ochoa | E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Gene overexpressed in astrocytoma protein) (RING finger protein 100) (Tripartite motif-containing protein 47) | E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. {ECO:0000269|PubMed:29291351}. |
| Q96QB1 | DLC1 | S1296 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96QE3 | ATAD5 | S369 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96RL1 | UIMC1 | S419 | ochoa|psp | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99460 | PSMD1 | S315 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q9BT25 | HAUS8 | S352 | ochoa | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9H089 | LSG1 | S272 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H0U4 | RAB1B | S111 | ochoa | Ras-related protein Rab-1B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}. |
| Q9H334 | FOXP1 | S37 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H4A3 | WNK1 | S2005 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H9Q4 | NHEJ1 | S203 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9HCY8 | S100A14 | S83 | ochoa | Protein S100-A14 (S100 calcium-binding protein A14) (S114) | Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}. |
| Q9HD26 | GOPC | S439 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NPQ8 | RIC8A | S32 | ochoa | Chaperone Ric-8A (Synembryn-A) | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}. |
| Q9NQC7 | CYLD | S547 | ochoa | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NR45 | NANS | S248 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
| Q9NSV4 | DIAPH3 | S1173 | ochoa | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}. |
| Q9NV70 | EXOC1 | S297 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9NVG8 | TBC1D13 | S135 | ochoa | TBC1 domain family member 13 | Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. {ECO:0000250|UniProtKB:Q8R3D1}. |
| Q9NYP3 | DONSON | S139 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
| Q9P203 | BTBD7 | S1112 | ochoa | BTB/POZ domain-containing protein 7 | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}. |
| Q9P246 | STIM2 | S343 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P2E9 | RRBP1 | S978 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2N5 | RBM27 | S656 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9P2R3 | ANKFY1 | S861 | ochoa | Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif) | Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}. |
| Q9UBE0 | SAE1 | S185 | ochoa | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
| Q9UHB6 | LIMA1 | S490 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB9 | SRP68 | S267 | ochoa | Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38687, ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| Q9UJD0 | RIMS3 | S114 | ochoa | Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) | Regulates synaptic membrane exocytosis. {ECO:0000250}. |
| Q9UK61 | TASOR | S903 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UK61 | TASOR | S1206 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UK97 | FBXO9 | S145 | ochoa | F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:23263282, PubMed:34480022). Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (PubMed:23263282). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (PubMed:34480022). Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BK06, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:34480022}. |
| Q9UKL3 | CASP8AP2 | S1672 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKV3 | ACIN1 | S551 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UM01 | SLC7A7 | S25 | ochoa | Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). {ECO:0000250|UniProtKB:Q9R0S5, ECO:0000269|PubMed:10080182, ECO:0000269|PubMed:10655553, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:15776427, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}. |
| Q9UMD9 | COL17A1 | S374 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UQ26 | RIMS2 | S1215 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9UQ35 | SRRM2 | S1349 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2L5 | TRAPPC8 | S269 | ochoa | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
| Q9Y2Y0 | ARL2BP | S140 | ochoa | ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1) | Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. {ECO:0000269|PubMed:18234692}. |
| Q9Y485 | DMXL1 | S469 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4J8 | DTNA | S645 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y4J8 | DTNA | S714 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y5Z4 | HEBP2 | S141 | ochoa | Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) | Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}. |
| U3KPZ7 | LOC127814297 | S601 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| Q96RT7 | TUBGCP6 | S1437 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| O00506 | STK25 | S133 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| P30626 | SRI | S111 | Sugiyama | Sorcin (22 kDa protein) (CP-22) (CP22) (V19) | Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}. |
| Q15154 | PCM1 | S861 | Sugiyama | Pericentriolar material 1 protein (PCM-1) (hPCM-1) | Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:34782749}. |
| P10109 | FDX1 | Y142 | Sugiyama | Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin) | Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
| Q07021 | C1QBP | S106 | Sugiyama | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}. |
| Q03135 | CAV1 | S88 | SIGNOR|ELM|iPTMNet | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| P41279 | MAP3K8 | S368 | Sugiyama | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}. |
| P07237 | P4HB | S449 | Sugiyama | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| Q15181 | PPA1 | S127 | Sugiyama | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| P18859 | ATP5PF | S57 | Sugiyama | ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P02721, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| Q13526 | PIN1 | S108 | Sugiyama | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| P07942 | LAMB1 | S449 | Sugiyama | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| Q00534 | CDK6 | S138 | Sugiyama | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q15139 | PRKD1 | S460 | Sugiyama | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15349 | RPS6KA2 | S525 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q15418 | RPS6KA1 | S528 | Sugiyama | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q6PJT7 | ZC3H14 | S330 | Sugiyama | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6XUX3 | DSTYK | S770 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q13011 | ECH1 | S240 | Sugiyama | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) | Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}. |
| P50897 | PPT1 | S249 | Sugiyama | Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.2) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) | Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins (PubMed:12855696, PubMed:26731412, PubMed:8816748). In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine (PubMed:12855696). {ECO:0000269|PubMed:12855696, ECO:0000269|PubMed:26731412, ECO:0000269|PubMed:8816748}. |
| O15067 | PFAS | S225 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| Q9Y6E0 | STK24 | S149 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000014 | 4.869 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000014 | 4.869 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000023 | 4.630 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000025 | 4.601 |
| R-HSA-68886 | M Phase | 0.000036 | 4.439 |
| R-HSA-1640170 | Cell Cycle | 0.000033 | 4.479 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000054 | 4.269 |
| R-HSA-109581 | Apoptosis | 0.000089 | 4.051 |
| R-HSA-5357801 | Programmed Cell Death | 0.000152 | 3.819 |
| R-HSA-75153 | Apoptotic execution phase | 0.000170 | 3.770 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.000206 | 3.686 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.000943 | 3.026 |
| R-HSA-69275 | G2/M Transition | 0.001046 | 2.981 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.001124 | 2.949 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.001394 | 2.856 |
| R-HSA-380287 | Centrosome maturation | 0.001575 | 2.803 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.002107 | 2.676 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.002255 | 2.647 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.002569 | 2.590 |
| R-HSA-68882 | Mitotic Anaphase | 0.002894 | 2.538 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.002981 | 2.526 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.002956 | 2.529 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.003391 | 2.470 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.003378 | 2.471 |
| R-HSA-373760 | L1CAM interactions | 0.003414 | 2.467 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.003663 | 2.436 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.003741 | 2.427 |
| R-HSA-68875 | Mitotic Prophase | 0.004019 | 2.396 |
| R-HSA-162582 | Signal Transduction | 0.003898 | 2.409 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.004283 | 2.368 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.004283 | 2.368 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.004431 | 2.353 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.005086 | 2.294 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.004938 | 2.306 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.004978 | 2.303 |
| R-HSA-6798695 | Neutrophil degranulation | 0.005231 | 2.281 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.005418 | 2.266 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.005990 | 2.223 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.006388 | 2.195 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.008007 | 2.097 |
| R-HSA-199920 | CREB phosphorylation | 0.008007 | 2.097 |
| R-HSA-210991 | Basigin interactions | 0.006963 | 2.157 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.007715 | 2.113 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.007536 | 2.123 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.008838 | 2.054 |
| R-HSA-6807070 | PTEN Regulation | 0.008913 | 2.050 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.009791 | 2.009 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.011733 | 1.931 |
| R-HSA-444257 | RSK activation | 0.011733 | 1.931 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.013213 | 1.879 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.013154 | 1.881 |
| R-HSA-5617833 | Cilium Assembly | 0.013026 | 1.885 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.012242 | 1.912 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.013213 | 1.879 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 0.014610 | 1.835 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 0.014610 | 1.835 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 0.014610 | 1.835 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 0.014610 | 1.835 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 0.014610 | 1.835 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 0.014610 | 1.835 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.013830 | 1.859 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.013701 | 1.863 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.016616 | 1.779 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.016077 | 1.794 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.016616 | 1.779 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.017193 | 1.765 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.016926 | 1.771 |
| R-HSA-449147 | Signaling by Interleukins | 0.015810 | 1.801 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.017230 | 1.764 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.017580 | 1.755 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.018778 | 1.726 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.019340 | 1.714 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.020620 | 1.686 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.020998 | 1.678 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.020620 | 1.686 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.019716 | 1.705 |
| R-HSA-2262752 | Cellular responses to stress | 0.019853 | 1.702 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.023278 | 1.633 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.023664 | 1.626 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.023664 | 1.626 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.029008 | 1.537 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.029008 | 1.537 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.029008 | 1.537 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.029008 | 1.537 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 0.029008 | 1.537 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.029008 | 1.537 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.026461 | 1.577 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.032430 | 1.489 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.029073 | 1.537 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.026461 | 1.577 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.029504 | 1.530 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.032430 | 1.489 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.032430 | 1.489 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.032430 | 1.489 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.031813 | 1.497 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.026461 | 1.577 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.029057 | 1.537 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.032915 | 1.483 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 0.043197 | 1.365 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 0.043197 | 1.365 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.043197 | 1.365 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 0.043197 | 1.365 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.057179 | 1.243 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.057179 | 1.243 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.057179 | 1.243 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.057179 | 1.243 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.057179 | 1.243 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.057179 | 1.243 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.057179 | 1.243 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.057179 | 1.243 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.057179 | 1.243 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.057179 | 1.243 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.057179 | 1.243 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.084535 | 1.073 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.111101 | 0.954 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 0.124094 | 0.906 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.124094 | 0.906 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.136899 | 0.864 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.136899 | 0.864 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.136899 | 0.864 |
| R-HSA-196025 | Formation of annular gap junctions | 0.149517 | 0.825 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.161951 | 0.791 |
| R-HSA-190873 | Gap junction degradation | 0.161951 | 0.791 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.174204 | 0.759 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.186279 | 0.730 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.209904 | 0.678 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.221459 | 0.655 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.221459 | 0.655 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.099220 | 1.003 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.103839 | 0.984 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.103839 | 0.984 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.113247 | 0.946 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.113247 | 0.946 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.118030 | 0.928 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.127745 | 0.894 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.147697 | 0.831 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.152780 | 0.816 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.094067 | 1.027 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.078742 | 1.104 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.096757 | 1.014 |
| R-HSA-186763 | Downstream signal transduction | 0.103839 | 0.984 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.102920 | 0.987 |
| R-HSA-3000157 | Laminin interactions | 0.077088 | 1.113 |
| R-HSA-191650 | Regulation of gap junction activity | 0.084535 | 1.073 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.113247 | 0.946 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.081376 | 1.090 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.072874 | 1.137 |
| R-HSA-72172 | mRNA Splicing | 0.115299 | 0.938 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.076731 | 1.115 |
| R-HSA-164939 | Nef mediated downregulation of CD28 cell surface expression | 0.043197 | 1.365 |
| R-HSA-165158 | Activation of AKT2 | 0.097915 | 1.009 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.097915 | 1.009 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 0.149517 | 0.825 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.198178 | 0.703 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.034693 | 1.460 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.085737 | 1.067 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.137640 | 0.861 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.163047 | 0.788 |
| R-HSA-1268020 | Mitochondrial protein import | 0.085547 | 1.068 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.045753 | 1.340 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.111101 | 0.954 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.136899 | 0.864 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.108515 | 0.965 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.094661 | 1.024 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.099220 | 1.003 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.189201 | 0.723 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.189201 | 0.723 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.189201 | 0.723 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.142650 | 0.846 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.085547 | 1.068 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.080175 | 1.096 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.043411 | 1.362 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.158565 | 0.800 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.068739 | 1.163 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.050659 | 1.295 |
| R-HSA-203615 | eNOS activation | 0.122864 | 0.911 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 0.043197 | 1.365 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 0.043197 | 1.365 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.070957 | 1.149 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.084535 | 1.073 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.084535 | 1.073 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 0.084535 | 1.073 |
| R-HSA-165160 | PDE3B signalling | 0.111101 | 0.954 |
| R-HSA-109703 | PKB-mediated events | 0.111101 | 0.954 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.111101 | 0.954 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.136899 | 0.864 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 0.136899 | 0.864 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.045753 | 1.340 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.174204 | 0.759 |
| R-HSA-192905 | vRNP Assembly | 0.186279 | 0.730 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.209904 | 0.678 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.209904 | 0.678 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.209904 | 0.678 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.221459 | 0.655 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.044315 | 1.353 |
| R-HSA-437239 | Recycling pathway of L1 | 0.048498 | 1.314 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.103839 | 0.984 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.059761 | 1.224 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.137640 | 0.861 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.189201 | 0.723 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.221247 | 0.655 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.226635 | 0.645 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.049750 | 1.303 |
| R-HSA-9646399 | Aggrephagy | 0.152780 | 0.816 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.189201 | 0.723 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.194768 | 0.710 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 0.174204 | 0.759 |
| R-HSA-3371511 | HSF1 activation | 0.132672 | 0.877 |
| R-HSA-9612973 | Autophagy | 0.045275 | 1.344 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.064685 | 1.189 |
| R-HSA-8963888 | Chylomicron assembly | 0.186279 | 0.730 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.186279 | 0.730 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.118030 | 0.928 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.167090 | 0.777 |
| R-HSA-1632852 | Macroautophagy | 0.085764 | 1.067 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.103839 | 0.984 |
| R-HSA-199991 | Membrane Trafficking | 0.040145 | 1.396 |
| R-HSA-9663891 | Selective autophagy | 0.172792 | 0.762 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 0.057179 | 1.243 |
| R-HSA-9675132 | Diseases of cellular response to stress | 0.057179 | 1.243 |
| R-HSA-8981607 | Intracellular oxygen transport | 0.070957 | 1.149 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 0.097915 | 1.009 |
| R-HSA-8964041 | LDL remodeling | 0.136899 | 0.864 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.056834 | 1.245 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.072874 | 1.137 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.198178 | 0.703 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.108515 | 0.965 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.127745 | 0.894 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.127745 | 0.894 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.163047 | 0.788 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.163047 | 0.788 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.118372 | 0.927 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.194500 | 0.711 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.221247 | 0.655 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.226635 | 0.645 |
| R-HSA-68877 | Mitotic Prometaphase | 0.038858 | 1.411 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.043282 | 1.364 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.199819 | 0.699 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.065765 | 1.182 |
| R-HSA-450294 | MAP kinase activation | 0.082784 | 1.082 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.118372 | 0.927 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.198497 | 0.702 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.205154 | 0.688 |
| R-HSA-194138 | Signaling by VEGF | 0.057465 | 1.241 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.209904 | 0.678 |
| R-HSA-4641258 | Degradation of DVL | 0.137640 | 0.861 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.085547 | 1.068 |
| R-HSA-448424 | Interleukin-17 signaling | 0.109000 | 0.963 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.042110 | 1.376 |
| R-HSA-1474290 | Collagen formation | 0.198497 | 0.702 |
| R-HSA-425381 | Bicarbonate transporters | 0.186279 | 0.730 |
| R-HSA-425561 | Sodium/Calcium exchangers | 0.198178 | 0.703 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.081376 | 1.090 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.209904 | 0.678 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.132672 | 0.877 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.132672 | 0.877 |
| R-HSA-4641257 | Degradation of AXIN | 0.137640 | 0.861 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.137640 | 0.861 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.147697 | 0.831 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.152780 | 0.816 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.157898 | 0.802 |
| R-HSA-69481 | G2/M Checkpoints | 0.060298 | 1.220 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.215870 | 0.666 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.232032 | 0.634 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.103839 | 0.984 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.049349 | 1.307 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.044315 | 1.353 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.113247 | 0.946 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.124781 | 0.904 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.066268 | 1.179 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.096566 | 1.015 |
| R-HSA-3371556 | Cellular response to heat stress | 0.139753 | 0.855 |
| R-HSA-8866423 | VLDL assembly | 0.124094 | 0.906 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.186279 | 0.730 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.198178 | 0.703 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.046383 | 1.334 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.113247 | 0.946 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.057418 | 1.241 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.118030 | 0.928 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.122864 | 0.911 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.122864 | 0.911 |
| R-HSA-169911 | Regulation of Apoptosis | 0.127745 | 0.894 |
| R-HSA-3371568 | Attenuation phase | 0.152780 | 0.816 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.163047 | 0.788 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.163047 | 0.788 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.115215 | 0.938 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.210505 | 0.677 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.221247 | 0.655 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.108026 | 0.966 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.046915 | 1.329 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.118612 | 0.926 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.072132 | 1.142 |
| R-HSA-1500620 | Meiosis | 0.158565 | 0.800 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.208318 | 0.681 |
| R-HSA-264876 | Insulin processing | 0.085737 | 1.067 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.035594 | 1.449 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.161951 | 0.791 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.209904 | 0.678 |
| R-HSA-354192 | Integrin signaling | 0.113247 | 0.946 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.113247 | 0.946 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.147697 | 0.831 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.152780 | 0.816 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.157898 | 0.802 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.157898 | 0.802 |
| R-HSA-4086400 | PCP/CE pathway | 0.134624 | 0.871 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.226635 | 0.645 |
| R-HSA-1221632 | Meiotic synapsis | 0.226635 | 0.645 |
| R-HSA-69206 | G1/S Transition | 0.153188 | 0.815 |
| R-HSA-422475 | Axon guidance | 0.042027 | 1.376 |
| R-HSA-9675108 | Nervous system development | 0.063992 | 1.194 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.112015 | 0.951 |
| R-HSA-9659379 | Sensory processing of sound | 0.137963 | 0.860 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.228896 | 0.640 |
| R-HSA-9907900 | Proteasome assembly | 0.178665 | 0.748 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.183922 | 0.735 |
| R-HSA-2559583 | Cellular Senescence | 0.075676 | 1.121 |
| R-HSA-198753 | ERK/MAPK targets | 0.056834 | 1.245 |
| R-HSA-9635465 | Suppression of apoptosis | 0.186279 | 0.730 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.186279 | 0.730 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.085737 | 1.067 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.147697 | 0.831 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.147697 | 0.831 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.102920 | 0.987 |
| R-HSA-8854214 | TBC/RABGAPs | 0.173432 | 0.761 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.173432 | 0.761 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.178665 | 0.748 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.183922 | 0.735 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.217387 | 0.663 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.217387 | 0.663 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.217387 | 0.663 |
| R-HSA-392499 | Metabolism of proteins | 0.082879 | 1.082 |
| R-HSA-597592 | Post-translational protein modification | 0.053604 | 1.271 |
| R-HSA-165159 | MTOR signalling | 0.168226 | 0.774 |
| R-HSA-162906 | HIV Infection | 0.159293 | 0.798 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.148146 | 0.829 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.126740 | 0.897 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.136206 | 0.866 |
| R-HSA-70171 | Glycolysis | 0.225047 | 0.648 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.228896 | 0.640 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.221459 | 0.655 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.094661 | 1.024 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.069572 | 1.158 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.183922 | 0.735 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.124781 | 0.904 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.066223 | 1.179 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.190212 | 0.721 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.087504 | 1.058 |
| R-HSA-5688426 | Deubiquitination | 0.113870 | 0.944 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.088349 | 1.054 |
| R-HSA-8848021 | Signaling by PTK6 | 0.088349 | 1.054 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.186279 | 0.730 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.068739 | 1.163 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.152780 | 0.816 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.157898 | 0.802 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.183922 | 0.735 |
| R-HSA-69242 | S Phase | 0.229730 | 0.639 |
| R-HSA-112316 | Neuronal System | 0.187030 | 0.728 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.067055 | 1.174 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.056336 | 1.249 |
| R-HSA-9830364 | Formation of the nephric duct | 0.077088 | 1.113 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.099220 | 1.003 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.115215 | 0.938 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.149517 | 0.825 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.161951 | 0.791 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.060715 | 1.217 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.221459 | 0.655 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.109000 | 0.963 |
| R-HSA-9766229 | Degradation of CDH1 | 0.205154 | 0.688 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.215870 | 0.666 |
| R-HSA-211000 | Gene Silencing by RNA | 0.100309 | 0.999 |
| R-HSA-70326 | Glucose metabolism | 0.129365 | 0.888 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.179133 | 0.747 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.116861 | 0.932 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.229730 | 0.639 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.051355 | 1.289 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.070840 | 1.150 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.060715 | 1.217 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.072874 | 1.137 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.072874 | 1.137 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.183922 | 0.735 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.183922 | 0.735 |
| R-HSA-195721 | Signaling by WNT | 0.190918 | 0.719 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.127745 | 0.894 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.149517 | 0.825 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.215870 | 0.666 |
| R-HSA-202424 | Downstream TCR signaling | 0.180038 | 0.745 |
| R-HSA-373753 | Nephrin family interactions | 0.053044 | 1.275 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.081376 | 1.090 |
| R-HSA-446728 | Cell junction organization | 0.152748 | 0.816 |
| R-HSA-373755 | Semaphorin interactions | 0.088349 | 1.054 |
| R-HSA-425410 | Metal ion SLC transporters | 0.199819 | 0.699 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.119318 | 0.923 |
| R-HSA-1500931 | Cell-Cell communication | 0.062543 | 1.204 |
| R-HSA-69541 | Stabilization of p53 | 0.147697 | 0.831 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.211224 | 0.675 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.069572 | 1.158 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.104134 | 0.982 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.158565 | 0.800 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.199168 | 0.701 |
| R-HSA-168256 | Immune System | 0.223086 | 0.652 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.122864 | 0.911 |
| R-HSA-168249 | Innate Immune System | 0.194690 | 0.711 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.128032 | 0.893 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.131705 | 0.880 |
| R-HSA-9824272 | Somitogenesis | 0.183922 | 0.735 |
| R-HSA-5619102 | SLC transporter disorders | 0.139387 | 0.856 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.101729 | 0.993 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.178665 | 0.748 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.205154 | 0.688 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.205154 | 0.688 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.221247 | 0.655 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.086695 | 1.062 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.179843 | 0.745 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.052987 | 1.276 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.157244 | 0.803 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.063369 | 1.198 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.221210 | 0.655 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.169201 | 0.772 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.147697 | 0.831 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.221247 | 0.655 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.232846 | 0.633 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.232846 | 0.633 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.232846 | 0.633 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.232846 | 0.633 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.232846 | 0.633 |
| R-HSA-435354 | Zinc transporters | 0.232846 | 0.633 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.237438 | 0.624 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.240517 | 0.619 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.242850 | 0.615 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.244067 | 0.612 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.244067 | 0.612 |
| R-HSA-9857492 | Protein lipoylation | 0.244067 | 0.612 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.244067 | 0.612 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.244067 | 0.612 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.244067 | 0.612 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.244067 | 0.612 |
| R-HSA-9609507 | Protein localization | 0.245450 | 0.610 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.246771 | 0.608 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.248319 | 0.605 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.255124 | 0.593 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.255124 | 0.593 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.255124 | 0.593 |
| R-HSA-69239 | Synthesis of DNA | 0.256159 | 0.591 |
| R-HSA-397014 | Muscle contraction | 0.257722 | 0.589 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.259113 | 0.587 |
| R-HSA-191859 | snRNP Assembly | 0.259113 | 0.587 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.259113 | 0.587 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.259113 | 0.587 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.259113 | 0.587 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.260092 | 0.585 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.264033 | 0.578 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.264033 | 0.578 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.264538 | 0.578 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.264538 | 0.578 |
| R-HSA-351202 | Metabolism of polyamines | 0.264538 | 0.578 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.266021 | 0.575 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.267982 | 0.572 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.267982 | 0.572 |
| R-HSA-202403 | TCR signaling | 0.267982 | 0.572 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.269964 | 0.569 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.269964 | 0.569 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.269964 | 0.569 |
| R-HSA-186797 | Signaling by PDGF | 0.275389 | 0.560 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.275389 | 0.560 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.276758 | 0.558 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.276758 | 0.558 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.276758 | 0.558 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.276758 | 0.558 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.276758 | 0.558 |
| R-HSA-2028269 | Signaling by Hippo | 0.276758 | 0.558 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.279867 | 0.553 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.280797 | 0.552 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.280812 | 0.552 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.286231 | 0.543 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.286231 | 0.543 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.287340 | 0.542 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.287340 | 0.542 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.287340 | 0.542 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.287340 | 0.542 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.287340 | 0.542 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.287340 | 0.542 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.291647 | 0.535 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.291647 | 0.535 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.291801 | 0.535 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.295787 | 0.529 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.297767 | 0.526 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.297767 | 0.526 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.297767 | 0.526 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.297767 | 0.526 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.297767 | 0.526 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.297767 | 0.526 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.297767 | 0.526 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.302462 | 0.519 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.302462 | 0.519 |
| R-HSA-9830369 | Kidney development | 0.302462 | 0.519 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.307859 | 0.512 |
| R-HSA-382551 | Transport of small molecules | 0.307937 | 0.512 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.308042 | 0.511 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.308042 | 0.511 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.308042 | 0.511 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.308042 | 0.511 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.308042 | 0.511 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.308042 | 0.511 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.308042 | 0.511 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.308042 | 0.511 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.308042 | 0.511 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.308042 | 0.511 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.308042 | 0.511 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.308042 | 0.511 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.311762 | 0.506 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.311762 | 0.506 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.311762 | 0.506 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.318167 | 0.497 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.318167 | 0.497 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.318167 | 0.497 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.318167 | 0.497 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.318627 | 0.497 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.318627 | 0.497 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.318627 | 0.497 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.323761 | 0.490 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.323761 | 0.490 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.323997 | 0.489 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.323997 | 0.489 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.323997 | 0.489 |
| R-HSA-8978934 | Metabolism of cofactors | 0.323997 | 0.489 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.323997 | 0.489 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.327761 | 0.484 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.328145 | 0.484 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.328404 | 0.484 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.329357 | 0.482 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.329357 | 0.482 |
| R-HSA-168255 | Influenza Infection | 0.333412 | 0.477 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.334704 | 0.475 |
| R-HSA-157118 | Signaling by NOTCH | 0.337053 | 0.472 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.337978 | 0.471 |
| R-HSA-8964038 | LDL clearance | 0.337978 | 0.471 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.340039 | 0.468 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.340039 | 0.468 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.340039 | 0.468 |
| R-HSA-9679506 | SARS-CoV Infections | 0.342836 | 0.465 |
| R-HSA-72766 | Translation | 0.344502 | 0.463 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.347667 | 0.459 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.347667 | 0.459 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.347667 | 0.459 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.347667 | 0.459 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.347667 | 0.459 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.347667 | 0.459 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.347667 | 0.459 |
| R-HSA-3000170 | Syndecan interactions | 0.347667 | 0.459 |
| R-HSA-5689603 | UCH proteinases | 0.350670 | 0.455 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.351746 | 0.454 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.357215 | 0.447 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.357215 | 0.447 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.357215 | 0.447 |
| R-HSA-5619084 | ABC transporter disorders | 0.361241 | 0.442 |
| R-HSA-1474165 | Reproduction | 0.363707 | 0.439 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.366623 | 0.436 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.366623 | 0.436 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.366623 | 0.436 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.366623 | 0.436 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.366623 | 0.436 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.366623 | 0.436 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.366623 | 0.436 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.371662 | 0.430 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.371748 | 0.430 |
| R-HSA-6806834 | Signaling by MET | 0.371748 | 0.430 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.375895 | 0.425 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.375895 | 0.425 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.375895 | 0.425 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.375895 | 0.425 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.375895 | 0.425 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.375895 | 0.425 |
| R-HSA-70635 | Urea cycle | 0.375895 | 0.425 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.375895 | 0.425 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.375895 | 0.425 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.375895 | 0.425 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.376977 | 0.424 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.382187 | 0.418 |
| R-HSA-8949613 | Cristae formation | 0.385032 | 0.415 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.385032 | 0.415 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 0.385032 | 0.415 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.385032 | 0.415 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.385032 | 0.415 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.387378 | 0.412 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.392551 | 0.406 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.394035 | 0.404 |
| R-HSA-77387 | Insulin receptor recycling | 0.394035 | 0.404 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.394035 | 0.404 |
| R-HSA-622312 | Inflammasomes | 0.394035 | 0.404 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.395408 | 0.403 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.399344 | 0.399 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.402836 | 0.395 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.402836 | 0.395 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.402836 | 0.395 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.402907 | 0.395 |
| R-HSA-209968 | Thyroxine biosynthesis | 0.402907 | 0.395 |
| R-HSA-5334118 | DNA methylation | 0.402907 | 0.395 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.402907 | 0.395 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.402907 | 0.395 |
| R-HSA-416476 | G alpha (q) signalling events | 0.406560 | 0.391 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.407948 | 0.389 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.411110 | 0.386 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.411649 | 0.385 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.411649 | 0.385 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.411649 | 0.385 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.411649 | 0.385 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.411649 | 0.385 |
| R-HSA-112311 | Neurotransmitter clearance | 0.411649 | 0.385 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.411649 | 0.385 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.413038 | 0.384 |
| R-HSA-1474244 | Extracellular matrix organization | 0.413444 | 0.384 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.418413 | 0.378 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.418915 | 0.378 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.420265 | 0.376 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.420265 | 0.376 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.420265 | 0.376 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.423154 | 0.374 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.428179 | 0.368 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.437120 | 0.359 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.437120 | 0.359 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.437120 | 0.359 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.437120 | 0.359 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.437120 | 0.359 |
| R-HSA-9930044 | Nuclear RNA decay | 0.437120 | 0.359 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.437120 | 0.359 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.437120 | 0.359 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.437120 | 0.359 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.437120 | 0.359 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.437120 | 0.359 |
| R-HSA-166520 | Signaling by NTRKs | 0.442117 | 0.354 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.443112 | 0.353 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.443112 | 0.353 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.443112 | 0.353 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.445364 | 0.351 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.445364 | 0.351 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.445364 | 0.351 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.445364 | 0.351 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.445364 | 0.351 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.445470 | 0.351 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.449774 | 0.347 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.452948 | 0.344 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.453487 | 0.343 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.453487 | 0.343 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.453487 | 0.343 |
| R-HSA-5205647 | Mitophagy | 0.453487 | 0.343 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.453487 | 0.343 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.453487 | 0.343 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.453586 | 0.343 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.457387 | 0.340 |
| R-HSA-1643685 | Disease | 0.459194 | 0.338 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.461177 | 0.336 |
| R-HSA-69306 | DNA Replication | 0.461177 | 0.336 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.461492 | 0.336 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.461492 | 0.336 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.461492 | 0.336 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.461492 | 0.336 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.462685 | 0.335 |
| R-HSA-418990 | Adherens junctions interactions | 0.464784 | 0.333 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.464956 | 0.333 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.467515 | 0.330 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.467515 | 0.330 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.468724 | 0.329 |
| R-HSA-8853659 | RET signaling | 0.469380 | 0.328 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.469380 | 0.328 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.469380 | 0.328 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.469380 | 0.328 |
| R-HSA-163560 | Triglyceride catabolism | 0.469380 | 0.328 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.469380 | 0.328 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.472319 | 0.326 |
| R-HSA-74160 | Gene expression (Transcription) | 0.473462 | 0.325 |
| R-HSA-8951664 | Neddylation | 0.474353 | 0.324 |
| R-HSA-162587 | HIV Life Cycle | 0.476223 | 0.322 |
| R-HSA-422356 | Regulation of insulin secretion | 0.477098 | 0.321 |
| R-HSA-419037 | NCAM1 interactions | 0.477154 | 0.321 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.477154 | 0.321 |
| R-HSA-2142789 | Ubiquinol biosynthesis | 0.477154 | 0.321 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.477154 | 0.321 |
| R-HSA-8948216 | Collagen chain trimerization | 0.477154 | 0.321 |
| R-HSA-877300 | Interferon gamma signaling | 0.483674 | 0.315 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.484813 | 0.314 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.484813 | 0.314 |
| R-HSA-9931953 | Biofilm formation | 0.484813 | 0.314 |
| R-HSA-8875878 | MET promotes cell motility | 0.484813 | 0.314 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.484813 | 0.314 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.484813 | 0.314 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.486576 | 0.313 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.486576 | 0.313 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.486576 | 0.313 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.487380 | 0.312 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.492361 | 0.308 |
| R-HSA-201556 | Signaling by ALK | 0.492361 | 0.308 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.492361 | 0.308 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.495946 | 0.305 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.495946 | 0.305 |
| R-HSA-1483255 | PI Metabolism | 0.495946 | 0.305 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.499799 | 0.301 |
| R-HSA-71240 | Tryptophan catabolism | 0.499799 | 0.301 |
| R-HSA-1280218 | Adaptive Immune System | 0.506058 | 0.296 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.507129 | 0.295 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.507129 | 0.295 |
| R-HSA-9607240 | FLT3 Signaling | 0.507129 | 0.295 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.514351 | 0.289 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.514351 | 0.289 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.514351 | 0.289 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.514351 | 0.289 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.518893 | 0.285 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.521468 | 0.283 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.523398 | 0.281 |
| R-HSA-8939211 | ESR-mediated signaling | 0.524214 | 0.280 |
| R-HSA-72306 | tRNA processing | 0.527268 | 0.278 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.527875 | 0.277 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.527875 | 0.277 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.527875 | 0.277 |
| R-HSA-9710421 | Defective pyroptosis | 0.528481 | 0.277 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.528481 | 0.277 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.532324 | 0.274 |
| R-HSA-69236 | G1 Phase | 0.535392 | 0.271 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.535392 | 0.271 |
| R-HSA-190828 | Gap junction trafficking | 0.535392 | 0.271 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.535392 | 0.271 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.537848 | 0.269 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.537848 | 0.269 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.541345 | 0.267 |
| R-HSA-774815 | Nucleosome assembly | 0.542202 | 0.266 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.542202 | 0.266 |
| R-HSA-913531 | Interferon Signaling | 0.547554 | 0.262 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.548913 | 0.260 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.548913 | 0.260 |
| R-HSA-9675135 | Diseases of DNA repair | 0.548913 | 0.260 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.548913 | 0.260 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.548913 | 0.260 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.554138 | 0.256 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.555525 | 0.255 |
| R-HSA-5620924 | Intraflagellar transport | 0.562041 | 0.250 |
| R-HSA-70263 | Gluconeogenesis | 0.562041 | 0.250 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.562041 | 0.250 |
| R-HSA-421270 | Cell-cell junction organization | 0.565927 | 0.247 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.571066 | 0.243 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.571066 | 0.243 |
| R-HSA-109704 | PI3K Cascade | 0.574789 | 0.240 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.575225 | 0.240 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.575381 | 0.240 |
| R-HSA-5693538 | Homology Directed Repair | 0.579355 | 0.237 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.580334 | 0.236 |
| R-HSA-912446 | Meiotic recombination | 0.581024 | 0.236 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.587168 | 0.231 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.587168 | 0.231 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.591568 | 0.228 |
| R-HSA-73886 | Chromosome Maintenance | 0.591568 | 0.228 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.591568 | 0.228 |
| R-HSA-983712 | Ion channel transport | 0.591915 | 0.228 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.593222 | 0.227 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.593222 | 0.227 |
| R-HSA-72649 | Translation initiation complex formation | 0.599188 | 0.222 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.599562 | 0.222 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.605066 | 0.218 |
| R-HSA-1266738 | Developmental Biology | 0.605351 | 0.218 |
| R-HSA-8953854 | Metabolism of RNA | 0.609582 | 0.215 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.610859 | 0.214 |
| R-HSA-75893 | TNF signaling | 0.610859 | 0.214 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 0.610859 | 0.214 |
| R-HSA-5578775 | Ion homeostasis | 0.610859 | 0.214 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.610859 | 0.214 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.610859 | 0.214 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.613773 | 0.212 |
| R-HSA-9609690 | HCMV Early Events | 0.614255 | 0.212 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.614255 | 0.212 |
| R-HSA-112399 | IRS-mediated signalling | 0.616567 | 0.210 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.622192 | 0.206 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.622192 | 0.206 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.626648 | 0.203 |
| R-HSA-9033241 | Peroxisomal protein import | 0.627734 | 0.202 |
| R-HSA-4085001 | Sialic acid metabolism | 0.627734 | 0.202 |
| R-HSA-8979227 | Triglyceride metabolism | 0.627734 | 0.202 |
| R-HSA-186712 | Regulation of beta-cell development | 0.627734 | 0.202 |
| R-HSA-212436 | Generic Transcription Pathway | 0.631268 | 0.200 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.633196 | 0.198 |
| R-HSA-379724 | tRNA Aminoacylation | 0.633196 | 0.198 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.633910 | 0.198 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.638577 | 0.195 |
| R-HSA-112043 | PLC beta mediated events | 0.638577 | 0.195 |
| R-HSA-211976 | Endogenous sterols | 0.638577 | 0.195 |
| R-HSA-1442490 | Collagen degradation | 0.638577 | 0.195 |
| R-HSA-9909396 | Circadian clock | 0.641432 | 0.193 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.641432 | 0.193 |
| R-HSA-109582 | Hemostasis | 0.641728 | 0.193 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.643880 | 0.191 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.654255 | 0.184 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.654255 | 0.184 |
| R-HSA-163685 | Integration of energy metabolism | 0.659298 | 0.181 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.659298 | 0.181 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.659329 | 0.181 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.666243 | 0.176 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.669256 | 0.174 |
| R-HSA-112040 | G-protein mediated events | 0.669256 | 0.174 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.669256 | 0.174 |
| R-HSA-5218859 | Regulated Necrosis | 0.674111 | 0.171 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.683608 | 0.165 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.688253 | 0.162 |
| R-HSA-3000178 | ECM proteoglycans | 0.688253 | 0.162 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.688253 | 0.162 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.689657 | 0.161 |
| R-HSA-4086398 | Ca2+ pathway | 0.697340 | 0.157 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.697340 | 0.157 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.701785 | 0.154 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.701785 | 0.154 |
| R-HSA-9758941 | Gastrulation | 0.705544 | 0.151 |
| R-HSA-8852135 | Protein ubiquitination | 0.706164 | 0.151 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.708639 | 0.150 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.714749 | 0.146 |
| R-HSA-216083 | Integrin cell surface interactions | 0.718921 | 0.143 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.718921 | 0.143 |
| R-HSA-73887 | Death Receptor Signaling | 0.720751 | 0.142 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.723049 | 0.141 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.723049 | 0.141 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.727118 | 0.138 |
| R-HSA-9610379 | HCMV Late Events | 0.729555 | 0.137 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.732437 | 0.135 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.753976 | 0.123 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.757592 | 0.121 |
| R-HSA-70268 | Pyruvate metabolism | 0.757592 | 0.121 |
| R-HSA-9609646 | HCMV Infection | 0.760506 | 0.119 |
| R-HSA-73884 | Base Excision Repair | 0.768125 | 0.115 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.770120 | 0.113 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.772627 | 0.112 |
| R-HSA-391251 | Protein folding | 0.778201 | 0.109 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.780007 | 0.108 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.790962 | 0.102 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.794036 | 0.100 |
| R-HSA-157579 | Telomere Maintenance | 0.797065 | 0.099 |
| R-HSA-9824446 | Viral Infection Pathways | 0.801891 | 0.096 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.802991 | 0.095 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.808654 | 0.092 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.811559 | 0.091 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.811559 | 0.091 |
| R-HSA-73894 | DNA Repair | 0.811943 | 0.090 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.815836 | 0.088 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.816703 | 0.088 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.817063 | 0.088 |
| R-HSA-111885 | Opioid Signalling | 0.817063 | 0.088 |
| R-HSA-9833110 | RSV-host interactions | 0.819755 | 0.086 |
| R-HSA-418346 | Platelet homeostasis | 0.825021 | 0.084 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.830134 | 0.081 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.830134 | 0.081 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.833748 | 0.079 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.839335 | 0.076 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.839335 | 0.076 |
| R-HSA-1483257 | Phospholipid metabolism | 0.843863 | 0.074 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.855707 | 0.068 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.856529 | 0.067 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.864023 | 0.063 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.868001 | 0.061 |
| R-HSA-114608 | Platelet degranulation | 0.877444 | 0.057 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.882470 | 0.054 |
| R-HSA-5576891 | Cardiac conduction | 0.886215 | 0.052 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.886215 | 0.052 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.889546 | 0.051 |
| R-HSA-5368287 | Mitochondrial translation | 0.898966 | 0.046 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.901925 | 0.045 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.901925 | 0.045 |
| R-HSA-9664407 | Parasite infection | 0.901925 | 0.045 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.907587 | 0.042 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.911206 | 0.040 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.921615 | 0.035 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.924958 | 0.034 |
| R-HSA-9711097 | Cellular response to starvation | 0.926066 | 0.033 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.932382 | 0.030 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.935336 | 0.029 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.936999 | 0.028 |
| R-HSA-9658195 | Leishmania infection | 0.936999 | 0.028 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.941737 | 0.026 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.941737 | 0.026 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.943447 | 0.025 |
| R-HSA-388396 | GPCR downstream signalling | 0.950109 | 0.022 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.951998 | 0.021 |
| R-HSA-418594 | G alpha (i) signalling events | 0.952204 | 0.021 |
| R-HSA-428157 | Sphingolipid metabolism | 0.961620 | 0.017 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.962558 | 0.017 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.962749 | 0.016 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.962749 | 0.016 |
| R-HSA-8957322 | Metabolism of steroids | 0.963025 | 0.016 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.970158 | 0.013 |
| R-HSA-5663205 | Infectious disease | 0.972104 | 0.012 |
| R-HSA-372790 | Signaling by GPCR | 0.975851 | 0.011 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.976904 | 0.010 |
| R-HSA-15869 | Metabolism of nucleotides | 0.977585 | 0.010 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.977734 | 0.010 |
| R-HSA-4839726 | Chromatin organization | 0.981547 | 0.008 |
| R-HSA-211859 | Biological oxidations | 0.987382 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 0.987391 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997946 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.998753 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999687 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999894 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999998 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.886 | 0.118 | 2 | 0.896 |
CLK3 |
0.878 | 0.218 | 1 | 0.847 |
CDC7 |
0.876 | 0.089 | 1 | 0.853 |
IKKB |
0.874 | 0.004 | -2 | 0.774 |
MOS |
0.874 | 0.104 | 1 | 0.889 |
CAMK1B |
0.873 | 0.113 | -3 | 0.887 |
PIM3 |
0.873 | 0.106 | -3 | 0.854 |
RAF1 |
0.872 | 0.006 | 1 | 0.878 |
PRPK |
0.872 | -0.089 | -1 | 0.833 |
MTOR |
0.871 | -0.049 | 1 | 0.839 |
PRKD1 |
0.871 | 0.158 | -3 | 0.817 |
DSTYK |
0.871 | 0.021 | 2 | 0.903 |
TBK1 |
0.870 | -0.027 | 1 | 0.800 |
CDKL1 |
0.870 | 0.124 | -3 | 0.838 |
GCN2 |
0.869 | -0.135 | 2 | 0.834 |
ATR |
0.869 | 0.051 | 1 | 0.865 |
NLK |
0.869 | 0.068 | 1 | 0.852 |
NDR2 |
0.868 | 0.037 | -3 | 0.850 |
PRKD2 |
0.868 | 0.171 | -3 | 0.790 |
PDHK4 |
0.868 | -0.200 | 1 | 0.887 |
ERK5 |
0.868 | 0.112 | 1 | 0.825 |
CAMK2G |
0.867 | -0.034 | 2 | 0.823 |
IKKE |
0.867 | -0.038 | 1 | 0.794 |
RSK2 |
0.866 | 0.142 | -3 | 0.813 |
BMPR2 |
0.865 | -0.140 | -2 | 0.867 |
PDHK1 |
0.865 | -0.125 | 1 | 0.883 |
PKN3 |
0.864 | 0.061 | -3 | 0.839 |
HIPK4 |
0.864 | 0.129 | 1 | 0.813 |
CDKL5 |
0.864 | 0.126 | -3 | 0.826 |
WNK1 |
0.864 | 0.032 | -2 | 0.861 |
IKKA |
0.864 | 0.048 | -2 | 0.761 |
NEK6 |
0.863 | -0.035 | -2 | 0.826 |
NIK |
0.863 | 0.025 | -3 | 0.887 |
PIM1 |
0.863 | 0.144 | -3 | 0.821 |
ULK2 |
0.863 | -0.152 | 2 | 0.826 |
NEK7 |
0.863 | -0.098 | -3 | 0.826 |
GRK6 |
0.862 | 0.087 | 1 | 0.834 |
GRK1 |
0.862 | 0.091 | -2 | 0.799 |
MARK4 |
0.862 | 0.011 | 4 | 0.825 |
SKMLCK |
0.862 | 0.068 | -2 | 0.848 |
NUAK2 |
0.862 | 0.061 | -3 | 0.865 |
NDR1 |
0.861 | 0.027 | -3 | 0.850 |
CAMLCK |
0.861 | 0.056 | -2 | 0.852 |
KIS |
0.861 | 0.087 | 1 | 0.723 |
SRPK1 |
0.861 | 0.125 | -3 | 0.791 |
HUNK |
0.861 | -0.050 | 2 | 0.852 |
MST4 |
0.861 | 0.032 | 2 | 0.880 |
GRK5 |
0.860 | -0.083 | -3 | 0.863 |
P90RSK |
0.860 | 0.096 | -3 | 0.808 |
RSK3 |
0.860 | 0.098 | -3 | 0.804 |
P70S6KB |
0.860 | 0.093 | -3 | 0.833 |
ICK |
0.859 | 0.105 | -3 | 0.856 |
MAPKAPK3 |
0.859 | 0.086 | -3 | 0.788 |
MAPKAPK2 |
0.859 | 0.134 | -3 | 0.757 |
DAPK2 |
0.859 | 0.052 | -3 | 0.884 |
AMPKA1 |
0.858 | 0.038 | -3 | 0.862 |
CAMK2D |
0.858 | 0.022 | -3 | 0.845 |
PKN2 |
0.858 | 0.032 | -3 | 0.851 |
MLK1 |
0.857 | -0.099 | 2 | 0.847 |
RIPK3 |
0.857 | -0.093 | 3 | 0.729 |
BCKDK |
0.857 | -0.135 | -1 | 0.791 |
TSSK1 |
0.857 | 0.097 | -3 | 0.873 |
PKCD |
0.857 | 0.058 | 2 | 0.816 |
PKACG |
0.856 | 0.064 | -2 | 0.760 |
AURC |
0.856 | 0.111 | -2 | 0.681 |
TGFBR2 |
0.856 | -0.078 | -2 | 0.765 |
WNK3 |
0.855 | -0.172 | 1 | 0.862 |
TSSK2 |
0.855 | 0.058 | -5 | 0.859 |
PRKD3 |
0.855 | 0.129 | -3 | 0.782 |
FAM20C |
0.855 | 0.050 | 2 | 0.587 |
NIM1 |
0.855 | -0.008 | 3 | 0.780 |
LATS2 |
0.854 | -0.006 | -5 | 0.747 |
ULK1 |
0.854 | -0.176 | -3 | 0.783 |
CHAK2 |
0.854 | -0.080 | -1 | 0.812 |
GRK4 |
0.853 | -0.084 | -2 | 0.794 |
SRPK2 |
0.853 | 0.111 | -3 | 0.730 |
ATM |
0.852 | 0.012 | 1 | 0.812 |
CAMK4 |
0.852 | 0.001 | -3 | 0.845 |
MSK2 |
0.852 | 0.061 | -3 | 0.782 |
BMPR1B |
0.852 | 0.125 | 1 | 0.768 |
CAMK2B |
0.852 | 0.070 | 2 | 0.783 |
AMPKA2 |
0.852 | 0.041 | -3 | 0.838 |
CLK4 |
0.851 | 0.139 | -3 | 0.815 |
NEK9 |
0.851 | -0.135 | 2 | 0.871 |
ANKRD3 |
0.851 | -0.127 | 1 | 0.882 |
DYRK2 |
0.851 | 0.106 | 1 | 0.703 |
PAK1 |
0.850 | 0.036 | -2 | 0.781 |
PKACB |
0.850 | 0.136 | -2 | 0.691 |
DLK |
0.850 | -0.138 | 1 | 0.843 |
NUAK1 |
0.850 | 0.041 | -3 | 0.821 |
PKR |
0.849 | 0.044 | 1 | 0.859 |
MASTL |
0.849 | -0.278 | -2 | 0.818 |
CDK8 |
0.849 | 0.032 | 1 | 0.681 |
TGFBR1 |
0.849 | 0.039 | -2 | 0.779 |
QSK |
0.849 | 0.032 | 4 | 0.796 |
SRPK3 |
0.849 | 0.081 | -3 | 0.775 |
MNK2 |
0.849 | 0.043 | -2 | 0.798 |
AURB |
0.848 | 0.081 | -2 | 0.677 |
CLK1 |
0.848 | 0.142 | -3 | 0.791 |
ALK4 |
0.848 | -0.003 | -2 | 0.808 |
MELK |
0.848 | 0.029 | -3 | 0.822 |
TTBK2 |
0.848 | -0.153 | 2 | 0.742 |
RSK4 |
0.848 | 0.114 | -3 | 0.784 |
SIK |
0.848 | 0.047 | -3 | 0.801 |
RIPK1 |
0.848 | -0.168 | 1 | 0.839 |
PAK3 |
0.848 | -0.011 | -2 | 0.786 |
CAMK2A |
0.848 | 0.053 | 2 | 0.805 |
QIK |
0.848 | -0.043 | -3 | 0.853 |
PAK6 |
0.847 | 0.080 | -2 | 0.737 |
MLK2 |
0.847 | -0.140 | 2 | 0.849 |
JNK2 |
0.847 | 0.123 | 1 | 0.635 |
CLK2 |
0.847 | 0.197 | -3 | 0.791 |
IRE1 |
0.847 | -0.095 | 1 | 0.819 |
GRK7 |
0.847 | 0.065 | 1 | 0.778 |
LATS1 |
0.847 | 0.025 | -3 | 0.859 |
MSK1 |
0.846 | 0.091 | -3 | 0.782 |
SGK3 |
0.845 | 0.112 | -3 | 0.791 |
AKT2 |
0.845 | 0.131 | -3 | 0.746 |
PLK1 |
0.845 | -0.083 | -2 | 0.776 |
PRKX |
0.845 | 0.155 | -3 | 0.732 |
ALK2 |
0.845 | 0.069 | -2 | 0.791 |
JNK3 |
0.845 | 0.092 | 1 | 0.675 |
MARK2 |
0.845 | 0.010 | 4 | 0.742 |
MYLK4 |
0.844 | 0.055 | -2 | 0.778 |
P38A |
0.844 | 0.085 | 1 | 0.727 |
CDK19 |
0.844 | 0.040 | 1 | 0.639 |
NEK2 |
0.844 | -0.069 | 2 | 0.844 |
DNAPK |
0.844 | 0.044 | 1 | 0.780 |
CHK1 |
0.843 | 0.042 | -3 | 0.829 |
MEK1 |
0.843 | -0.136 | 2 | 0.865 |
PKCB |
0.843 | 0.014 | 2 | 0.773 |
MLK3 |
0.843 | -0.072 | 2 | 0.773 |
PHKG1 |
0.843 | -0.023 | -3 | 0.842 |
MARK3 |
0.843 | 0.008 | 4 | 0.763 |
PLK3 |
0.842 | -0.032 | 2 | 0.798 |
YSK4 |
0.842 | -0.113 | 1 | 0.820 |
AURA |
0.842 | 0.059 | -2 | 0.647 |
ACVR2B |
0.842 | 0.022 | -2 | 0.769 |
MNK1 |
0.841 | 0.025 | -2 | 0.810 |
VRK2 |
0.841 | -0.192 | 1 | 0.890 |
PKCG |
0.841 | -0.020 | 2 | 0.769 |
ACVR2A |
0.841 | -0.003 | -2 | 0.759 |
TLK2 |
0.841 | -0.032 | 1 | 0.842 |
PKG2 |
0.841 | 0.063 | -2 | 0.700 |
PKCA |
0.841 | -0.006 | 2 | 0.760 |
PKCZ |
0.841 | -0.034 | 2 | 0.812 |
PIM2 |
0.840 | 0.096 | -3 | 0.791 |
HIPK2 |
0.840 | 0.128 | 1 | 0.621 |
HIPK1 |
0.840 | 0.121 | 1 | 0.723 |
PAK2 |
0.840 | -0.033 | -2 | 0.772 |
MAPKAPK5 |
0.840 | -0.013 | -3 | 0.749 |
CDK13 |
0.839 | 0.011 | 1 | 0.671 |
P38B |
0.839 | 0.089 | 1 | 0.650 |
CAMK1G |
0.839 | 0.031 | -3 | 0.803 |
DYRK1A |
0.839 | 0.102 | 1 | 0.764 |
ERK1 |
0.839 | 0.065 | 1 | 0.646 |
IRE2 |
0.839 | -0.109 | 2 | 0.782 |
CDK7 |
0.839 | -0.002 | 1 | 0.695 |
SMG1 |
0.839 | -0.073 | 1 | 0.822 |
CDK5 |
0.839 | 0.047 | 1 | 0.711 |
CDK1 |
0.838 | 0.050 | 1 | 0.630 |
PKCH |
0.838 | -0.029 | 2 | 0.762 |
BRSK1 |
0.838 | -0.025 | -3 | 0.816 |
DCAMKL1 |
0.838 | 0.052 | -3 | 0.810 |
BRAF |
0.838 | -0.030 | -4 | 0.870 |
MLK4 |
0.838 | -0.099 | 2 | 0.758 |
HIPK3 |
0.838 | 0.100 | 1 | 0.742 |
CDK18 |
0.837 | 0.053 | 1 | 0.616 |
MARK1 |
0.837 | -0.026 | 4 | 0.780 |
BMPR1A |
0.837 | 0.108 | 1 | 0.751 |
CHAK1 |
0.837 | -0.162 | 2 | 0.802 |
BRSK2 |
0.836 | -0.072 | -3 | 0.830 |
PKACA |
0.835 | 0.114 | -2 | 0.652 |
ERK2 |
0.835 | 0.027 | 1 | 0.692 |
AKT1 |
0.835 | 0.122 | -3 | 0.754 |
WNK4 |
0.835 | -0.065 | -2 | 0.847 |
PERK |
0.835 | -0.128 | -2 | 0.819 |
CK1E |
0.835 | 0.024 | -3 | 0.609 |
PRP4 |
0.834 | 0.010 | -3 | 0.723 |
P70S6K |
0.834 | 0.057 | -3 | 0.757 |
P38G |
0.833 | 0.064 | 1 | 0.548 |
P38D |
0.833 | 0.113 | 1 | 0.588 |
PINK1 |
0.833 | -0.135 | 1 | 0.865 |
DYRK4 |
0.833 | 0.102 | 1 | 0.629 |
MEKK3 |
0.833 | -0.148 | 1 | 0.822 |
MEKK1 |
0.833 | -0.147 | 1 | 0.851 |
CAMK1D |
0.833 | 0.093 | -3 | 0.735 |
PHKG2 |
0.832 | 0.001 | -3 | 0.828 |
SMMLCK |
0.832 | 0.027 | -3 | 0.847 |
TLK1 |
0.832 | -0.106 | -2 | 0.786 |
SNRK |
0.832 | -0.176 | 2 | 0.731 |
CDK12 |
0.832 | 0.010 | 1 | 0.642 |
GRK2 |
0.832 | -0.092 | -2 | 0.697 |
HRI |
0.832 | -0.209 | -2 | 0.822 |
MEK5 |
0.832 | -0.236 | 2 | 0.862 |
PLK4 |
0.831 | -0.140 | 2 | 0.678 |
NEK5 |
0.831 | -0.092 | 1 | 0.869 |
CDK2 |
0.831 | -0.010 | 1 | 0.706 |
DCAMKL2 |
0.830 | 0.005 | -3 | 0.834 |
MEKK2 |
0.830 | -0.113 | 2 | 0.841 |
DYRK3 |
0.830 | 0.100 | 1 | 0.724 |
CAMKK1 |
0.830 | -0.007 | -2 | 0.827 |
DRAK1 |
0.830 | -0.118 | 1 | 0.744 |
MST3 |
0.830 | -0.026 | 2 | 0.869 |
CDK9 |
0.830 | -0.017 | 1 | 0.676 |
ZAK |
0.829 | -0.162 | 1 | 0.815 |
MPSK1 |
0.829 | 0.031 | 1 | 0.832 |
GAK |
0.829 | 0.070 | 1 | 0.859 |
IRAK4 |
0.829 | -0.107 | 1 | 0.832 |
CDK17 |
0.829 | 0.024 | 1 | 0.555 |
SSTK |
0.829 | -0.010 | 4 | 0.785 |
TAO3 |
0.829 | -0.047 | 1 | 0.830 |
DYRK1B |
0.829 | 0.073 | 1 | 0.657 |
PKCT |
0.828 | -0.009 | 2 | 0.770 |
PAK5 |
0.827 | 0.021 | -2 | 0.674 |
PASK |
0.827 | -0.009 | -3 | 0.869 |
CK1D |
0.826 | 0.025 | -3 | 0.556 |
LKB1 |
0.826 | 0.010 | -3 | 0.806 |
CAMKK2 |
0.826 | -0.006 | -2 | 0.831 |
CK1G1 |
0.826 | -0.009 | -3 | 0.601 |
CDK3 |
0.825 | 0.061 | 1 | 0.575 |
CDK14 |
0.825 | 0.035 | 1 | 0.662 |
PKCI |
0.825 | -0.012 | 2 | 0.779 |
PDK1 |
0.825 | -0.012 | 1 | 0.849 |
DAPK3 |
0.825 | 0.079 | -3 | 0.833 |
NEK8 |
0.824 | -0.126 | 2 | 0.855 |
CK1A2 |
0.824 | 0.022 | -3 | 0.561 |
GSK3A |
0.824 | -0.004 | 4 | 0.431 |
GSK3B |
0.824 | -0.044 | 4 | 0.419 |
TAK1 |
0.823 | 0.009 | 1 | 0.882 |
CHK2 |
0.823 | 0.093 | -3 | 0.692 |
TTBK1 |
0.822 | -0.170 | 2 | 0.663 |
SGK1 |
0.822 | 0.125 | -3 | 0.670 |
PAK4 |
0.822 | 0.019 | -2 | 0.678 |
NEK11 |
0.822 | -0.163 | 1 | 0.838 |
CK2A2 |
0.822 | 0.071 | 1 | 0.666 |
TAO2 |
0.822 | -0.104 | 2 | 0.872 |
PLK2 |
0.821 | 0.045 | -3 | 0.825 |
CAMK1A |
0.821 | 0.098 | -3 | 0.703 |
AKT3 |
0.821 | 0.115 | -3 | 0.681 |
CDK10 |
0.821 | 0.054 | 1 | 0.646 |
PKN1 |
0.821 | 0.048 | -3 | 0.768 |
MRCKB |
0.820 | 0.099 | -3 | 0.782 |
MAK |
0.820 | 0.157 | -2 | 0.745 |
GRK3 |
0.820 | -0.072 | -2 | 0.647 |
CDK16 |
0.820 | 0.042 | 1 | 0.580 |
PKCE |
0.819 | 0.024 | 2 | 0.754 |
NEK4 |
0.819 | -0.088 | 1 | 0.835 |
ERK7 |
0.819 | 0.006 | 2 | 0.552 |
MST2 |
0.819 | -0.082 | 1 | 0.836 |
JNK1 |
0.818 | 0.051 | 1 | 0.613 |
TNIK |
0.818 | -0.006 | 3 | 0.858 |
DAPK1 |
0.818 | 0.054 | -3 | 0.825 |
IRAK1 |
0.818 | -0.252 | -1 | 0.730 |
EEF2K |
0.818 | -0.040 | 3 | 0.820 |
GCK |
0.817 | -0.051 | 1 | 0.826 |
MRCKA |
0.817 | 0.078 | -3 | 0.794 |
MINK |
0.817 | -0.053 | 1 | 0.834 |
HGK |
0.816 | -0.061 | 3 | 0.854 |
MEKK6 |
0.816 | -0.107 | 1 | 0.840 |
ROCK2 |
0.816 | 0.093 | -3 | 0.813 |
SBK |
0.815 | 0.116 | -3 | 0.634 |
LOK |
0.815 | -0.049 | -2 | 0.804 |
NEK1 |
0.815 | -0.052 | 1 | 0.842 |
MAP3K15 |
0.815 | -0.110 | 1 | 0.815 |
LRRK2 |
0.814 | -0.142 | 2 | 0.878 |
HPK1 |
0.814 | -0.036 | 1 | 0.815 |
MOK |
0.813 | 0.126 | 1 | 0.738 |
DMPK1 |
0.812 | 0.132 | -3 | 0.803 |
PBK |
0.811 | 0.027 | 1 | 0.794 |
PDHK3_TYR |
0.811 | 0.190 | 4 | 0.869 |
SLK |
0.810 | -0.076 | -2 | 0.752 |
CK2A1 |
0.810 | 0.037 | 1 | 0.636 |
CDK4 |
0.810 | 0.021 | 1 | 0.627 |
CDK6 |
0.810 | 0.007 | 1 | 0.649 |
KHS1 |
0.809 | -0.017 | 1 | 0.826 |
BUB1 |
0.809 | 0.072 | -5 | 0.851 |
MST1 |
0.809 | -0.117 | 1 | 0.822 |
KHS2 |
0.809 | 0.011 | 1 | 0.829 |
VRK1 |
0.808 | -0.208 | 2 | 0.868 |
YSK1 |
0.807 | -0.092 | 2 | 0.846 |
MEK2 |
0.806 | -0.240 | 2 | 0.842 |
PKG1 |
0.806 | 0.036 | -2 | 0.611 |
RIPK2 |
0.805 | -0.257 | 1 | 0.788 |
ROCK1 |
0.804 | 0.077 | -3 | 0.789 |
CRIK |
0.804 | 0.099 | -3 | 0.746 |
STK33 |
0.803 | -0.201 | 2 | 0.652 |
NEK3 |
0.803 | -0.134 | 1 | 0.817 |
ALPHAK3 |
0.802 | 0.017 | -1 | 0.759 |
MAP2K4_TYR |
0.801 | -0.021 | -1 | 0.847 |
PDHK4_TYR |
0.801 | 0.032 | 2 | 0.904 |
MAP2K6_TYR |
0.801 | 0.003 | -1 | 0.854 |
OSR1 |
0.799 | -0.087 | 2 | 0.833 |
HASPIN |
0.799 | -0.003 | -1 | 0.703 |
BMPR2_TYR |
0.799 | 0.010 | -1 | 0.859 |
TESK1_TYR |
0.799 | -0.114 | 3 | 0.888 |
MAP2K7_TYR |
0.799 | -0.168 | 2 | 0.890 |
TTK |
0.798 | -0.067 | -2 | 0.777 |
PDHK1_TYR |
0.797 | -0.055 | -1 | 0.864 |
PINK1_TYR |
0.796 | -0.131 | 1 | 0.868 |
PKMYT1_TYR |
0.796 | -0.121 | 3 | 0.855 |
EPHA6 |
0.795 | 0.048 | -1 | 0.856 |
BIKE |
0.794 | 0.016 | 1 | 0.742 |
MYO3B |
0.793 | -0.083 | 2 | 0.849 |
LIMK2_TYR |
0.793 | -0.050 | -3 | 0.868 |
RET |
0.793 | -0.089 | 1 | 0.847 |
ASK1 |
0.791 | -0.165 | 1 | 0.808 |
TYK2 |
0.791 | -0.107 | 1 | 0.856 |
YANK3 |
0.791 | -0.073 | 2 | 0.422 |
TAO1 |
0.790 | -0.122 | 1 | 0.783 |
MYO3A |
0.790 | -0.109 | 1 | 0.816 |
JAK2 |
0.789 | -0.080 | 1 | 0.852 |
EPHB4 |
0.789 | -0.019 | -1 | 0.814 |
ABL2 |
0.788 | 0.011 | -1 | 0.808 |
MST1R |
0.787 | -0.146 | 3 | 0.812 |
LIMK1_TYR |
0.786 | -0.224 | 2 | 0.881 |
CK1A |
0.785 | -0.027 | -3 | 0.471 |
DDR1 |
0.785 | -0.155 | 4 | 0.794 |
CSF1R |
0.785 | -0.094 | 3 | 0.786 |
ROS1 |
0.785 | -0.136 | 3 | 0.770 |
JAK3 |
0.784 | -0.100 | 1 | 0.831 |
ABL1 |
0.784 | -0.003 | -1 | 0.801 |
TYRO3 |
0.783 | -0.170 | 3 | 0.801 |
FER |
0.782 | -0.091 | 1 | 0.867 |
YES1 |
0.782 | -0.052 | -1 | 0.818 |
EPHA4 |
0.782 | -0.022 | 2 | 0.791 |
LCK |
0.781 | 0.025 | -1 | 0.818 |
INSRR |
0.781 | -0.095 | 3 | 0.746 |
HCK |
0.781 | -0.050 | -1 | 0.809 |
STLK3 |
0.781 | -0.197 | 1 | 0.784 |
FGR |
0.781 | -0.119 | 1 | 0.847 |
NEK10_TYR |
0.781 | -0.066 | 1 | 0.772 |
TXK |
0.780 | 0.017 | 1 | 0.794 |
EPHB1 |
0.779 | -0.060 | 1 | 0.842 |
SRMS |
0.779 | -0.052 | 1 | 0.841 |
BLK |
0.779 | 0.044 | -1 | 0.831 |
FLT3 |
0.779 | -0.117 | 3 | 0.795 |
EPHB2 |
0.779 | -0.018 | -1 | 0.797 |
TNK2 |
0.778 | -0.086 | 3 | 0.777 |
JAK1 |
0.778 | -0.047 | 1 | 0.804 |
EPHB3 |
0.778 | -0.061 | -1 | 0.802 |
KIT |
0.777 | -0.120 | 3 | 0.786 |
TNNI3K_TYR |
0.776 | -0.052 | 1 | 0.832 |
FGFR2 |
0.776 | -0.170 | 3 | 0.792 |
AAK1 |
0.775 | 0.049 | 1 | 0.640 |
KDR |
0.775 | -0.142 | 3 | 0.751 |
PDGFRB |
0.774 | -0.205 | 3 | 0.805 |
ITK |
0.774 | -0.095 | -1 | 0.773 |
TNK1 |
0.774 | -0.131 | 3 | 0.778 |
FYN |
0.772 | 0.024 | -1 | 0.799 |
FGFR1 |
0.772 | -0.187 | 3 | 0.770 |
MET |
0.772 | -0.120 | 3 | 0.793 |
BTK |
0.772 | -0.167 | -1 | 0.725 |
TEC |
0.772 | -0.073 | -1 | 0.718 |
ALK |
0.770 | -0.135 | 3 | 0.729 |
EPHA7 |
0.770 | -0.072 | 2 | 0.797 |
TEK |
0.770 | -0.205 | 3 | 0.734 |
LTK |
0.769 | -0.131 | 3 | 0.744 |
FLT1 |
0.769 | -0.134 | -1 | 0.818 |
BMX |
0.769 | -0.087 | -1 | 0.702 |
FRK |
0.769 | -0.080 | -1 | 0.822 |
AXL |
0.768 | -0.185 | 3 | 0.775 |
MERTK |
0.768 | -0.145 | 3 | 0.776 |
PDGFRA |
0.768 | -0.252 | 3 | 0.802 |
EPHA3 |
0.768 | -0.129 | 2 | 0.771 |
WEE1_TYR |
0.768 | -0.153 | -1 | 0.708 |
NTRK1 |
0.768 | -0.206 | -1 | 0.793 |
LYN |
0.767 | -0.069 | 3 | 0.707 |
PTK6 |
0.766 | -0.203 | -1 | 0.699 |
FGFR3 |
0.766 | -0.165 | 3 | 0.762 |
ERBB2 |
0.766 | -0.189 | 1 | 0.779 |
CK1G3 |
0.765 | -0.035 | -3 | 0.426 |
INSR |
0.764 | -0.171 | 3 | 0.720 |
DDR2 |
0.763 | -0.086 | 3 | 0.739 |
EPHA5 |
0.763 | -0.069 | 2 | 0.780 |
EPHA1 |
0.763 | -0.154 | 3 | 0.763 |
NTRK2 |
0.763 | -0.232 | 3 | 0.757 |
MATK |
0.763 | -0.133 | -1 | 0.740 |
FLT4 |
0.762 | -0.224 | 3 | 0.737 |
SRC |
0.761 | -0.060 | -1 | 0.797 |
PTK2B |
0.761 | -0.071 | -1 | 0.768 |
EPHA8 |
0.761 | -0.082 | -1 | 0.800 |
PTK2 |
0.760 | 0.001 | -1 | 0.791 |
SYK |
0.760 | 0.014 | -1 | 0.772 |
EGFR |
0.760 | -0.103 | 1 | 0.683 |
CSK |
0.759 | -0.138 | 2 | 0.804 |
NTRK3 |
0.759 | -0.193 | -1 | 0.746 |
FGFR4 |
0.755 | -0.128 | -1 | 0.753 |
YANK2 |
0.754 | -0.113 | 2 | 0.431 |
EPHA2 |
0.751 | -0.098 | -1 | 0.760 |
IGF1R |
0.750 | -0.159 | 3 | 0.660 |
CK1G2 |
0.747 | -0.052 | -3 | 0.519 |
MUSK |
0.746 | -0.201 | 1 | 0.684 |
ERBB4 |
0.743 | -0.104 | 1 | 0.676 |
FES |
0.737 | -0.153 | -1 | 0.683 |
ZAP70 |
0.732 | -0.075 | -1 | 0.706 |