Motif 975 (n=209)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NI28 | ARHGAP42 | S383 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| A6NKT7 | RGPD3 | S395 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MVW0 | FAM171A2 | S512 | ochoa | Protein FAM171A2 | None |
| K7ERQ8 | None | S124 | ochoa | PCAF N-terminal domain-containing protein | None |
| O00151 | PDLIM1 | S250 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00410 | IPO5 | S635 | ochoa | Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}. |
| O14686 | KMT2D | S3463 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14745 | NHERF1 | S46 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O43707 | ACTN4 | S121 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43715 | TRIAP1 | S33 | ochoa | TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV) | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759, ECO:0000269|PubMed:26071602}. |
| O60516 | EIF4EBP3 | S21 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:22684010}. |
| O75582 | RPS6KA5 | S376 | ochoa|psp | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| O75762 | TRPA1 | S602 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O95466 | FMNL1 | S921 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| P04075 | ALDOA | S176 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P04280 | PRB1 | S24 | psp | Basic salivary proline-rich protein 1 (Salivary proline-rich protein) [Cleaved into: Proline-rich peptide II-2; Basic peptide IB-6; Peptide P-H] | None |
| P09651 | HNRNPA1 | S95 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P09972 | ALDOC | S176 | ochoa | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P0C0S8 | H2AC11 | T102 | ochoa | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P0C7T5 | ATXN1L | S292 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P10412 | H1-4 | S89 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10809 | HSPD1 | S383 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P12814 | ACTN1 | S102 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13056 | NR2C1 | S64 | ochoa | Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. {ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}. |
| P13639 | EEF2 | S595 | ochoa|psp | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P13798 | APEH | S187 | ochoa | Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) | This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}. |
| P16401 | H1-5 | S92 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S90 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S89 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P18206 | VCL | S434 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18583 | SON | S1688 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18669 | PGAM1 | S23 | ochoa|psp | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}. |
| P20339 | RAB5A | S123 | ochoa|psp | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P20671 | H2AC7 | T102 | ochoa | Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P22626 | HNRNPA2B1 | S102 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P25054 | APC | S80 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27708 | CAD | S1321 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P28290 | ITPRID2 | S98 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29017 | CD1C | S215 | ochoa | T-cell surface glycoprotein CD1c (CD antigen CD1c) | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10786796, ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:21167756}. |
| P29274 | ADORA2A | S329 | ochoa | Adenosine receptor A2a | Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| P30050 | RPL12 | S126 | ochoa | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P35609 | ACTN2 | S109 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P41227 | NAA10 | S205 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P42356 | PI4KA | S763 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
| P42568 | MLLT3 | S311 | ochoa | Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}. |
| P42684 | ABL2 | S953 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P45973 | CBX5 | S132 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P46531 | NOTCH1 | S2439 | psp | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P48047 | ATP5PO | S166 | ochoa | ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP synthase subunit O) (Oligomycin sensitivity conferral protein) (OSCP) | Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13621, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P49023 | PXN | S274 | psp | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49642 | PRIM1 | S310 | ochoa | DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) | Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed:17893144, PubMed:24043831, PubMed:25550159, PubMed:26975377, PubMed:31479243, PubMed:33060134, PubMed:9268648, PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs) (PubMed:26975377). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end (PubMed:25550159, PubMed:26975377). Binds single stranded DNA (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:33060134, ECO:0000269|PubMed:9268648, ECO:0000269|PubMed:9705292}. |
| P49790 | NUP153 | S661 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S394 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51148 | RAB5C | S124 | ochoa | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P51153 | RAB13 | S111 | ochoa|psp | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
| P51398 | DAP3 | S252 | psp | Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}. |
| P51523 | ZNF84 | S128 | ochoa | Zinc finger protein 84 (Zinc finger protein HPF2) | May be involved in transcriptional regulation. |
| P51991 | HNRNPA3 | S116 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P52788 | SMS | S104 | ochoa | Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase) | Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). {ECO:0000269|PubMed:18367445, ECO:0000269|PubMed:18550699, ECO:0000269|PubMed:23696453, ECO:0000269|PubMed:23897707}. |
| P52948 | NUP98 | S494 | psp | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P53396 | ACLY | S663 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P55011 | SLC12A2 | S994 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P55268 | LAMB2 | S1548 | ochoa | Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P60709 | ACTB | S234 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61020 | RAB5B | S123 | ochoa|psp | Ras-related protein Rab-5B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P61289 | PSME3 | S43 | ochoa | Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}. |
| P61981 | YWHAG | S38 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62736 | ACTA2 | S236 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S234 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S235 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S236 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S236 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78344 | EIF4G2 | S443 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P83916 | CBX1 | S128 | ochoa | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
| Q00653 | NFKB2 | S739 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q00G26 | PLIN5 | S148 | ochoa | Perilipin-5 (Lipid storage droplet protein 5) | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250, ECO:0000269|PubMed:17234449}. |
| Q01538 | MYT1 | S105 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
| Q01968 | OCRL | S716 | ochoa | Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86) | Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:10764818, PubMed:15474001, PubMed:7761412, PubMed:9430698). Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:25869668, PubMed:7761412). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:15474001, ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:22072788, ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:7761412, ECO:0000269|PubMed:9430698}. |
| Q02078 | MEF2A | S59 | psp | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q04726 | TLE3 | S240 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q05209 | PTPN12 | S398 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q06413 | MEF2C | S59 | psp | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q06830 | PRDX1 | S152 | ochoa | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q08043 | ACTN3 | S116 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q08050 | FOXM1 | S717 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q09666 | AHNAK | S5499 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12770 | SCAP | S483 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q12772 | SREBF2 | S1098 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12800 | TFCP2 | S353 | ochoa | Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) | Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}. |
| Q12802 | AKAP13 | S2436 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13185 | CBX3 | S132 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13263 | TRIM28 | S689 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13416 | ORC2 | S280 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13459 | MYO9B | S83 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13796 | SHROOM2 | S456 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13796 | SHROOM2 | S1524 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13936 | CACNA1C | S1535 | psp | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:25260352, ECO:0000269|PubMed:25633834, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:31430211, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:8099908, ECO:0000305}.; FUNCTION: [Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:8392192}.; FUNCTION: [Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:11741969}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. |
| Q14154 | DELE1 | S474 | ochoa | DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1) (cDELE1)] | Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks (PubMed:32132706, PubMed:32132707, PubMed:35388015, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed:35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:35388015, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}.; FUNCTION: [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. {ECO:0000269|PubMed:37327776}.; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546). Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (PubMed:38340717). {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}. |
| Q14185 | DOCK1 | S1807 | ochoa | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}. |
| Q14191 | WRN | S1400 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q15149 | PLEC | S476 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15596 | NCOA2 | S699 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15633 | TARBP2 | S246 | ochoa | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250|UniProtKB:P97473, ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:11438532, PubMed:12475984, PubMed:2011739). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269|PubMed:11438532, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:2011739, ECO:0000269|PubMed:30626973}. |
| Q15643 | TRIP11 | S383 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15758 | SLC1A5 | S503 | ochoa|psp | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
| Q16777 | H2AC20 | T102 | ochoa | Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q2LD37 | BLTP1 | S3196 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2NKX8 | ERCC6L | S1173 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2PPJ7 | RALGAPA2 | S820 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q32P51 | HNRNPA1L2 | S95 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q53ET0 | CRTC2 | S64 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q562R1 | ACTBL2 | S235 | ochoa | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
| Q5JTH9 | RRP12 | S92 | ochoa | RRP12-like protein | None |
| Q5SW79 | CEP170 | S887 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5THK1 | PRR14L | S1971 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5UIP0 | RIF1 | S1793 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VST9 | OBSCN | S6942 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VWN6 | TASOR2 | S867 | ochoa | Protein TASOR 2 | None |
| Q5VZ89 | DENND4C | S1355 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5VZL5 | ZMYM4 | S1068 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q6FI13 | H2AC18 | T102 | ochoa | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6IQ55 | TTBK2 | S407 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6PCD5 | RFWD3 | S46 | psp | E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) | E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094). {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:28575657, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:28691929, ECO:0000269|PubMed:33321094}. |
| Q6S8J3 | POTEE | S934 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q7Z3J3 | RGPD4 | S395 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3S7 | CACNA2D4 | S499 | ochoa | Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}. |
| Q7Z3T8 | ZFYVE16 | S319 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q86Y56 | DNAAF5 | S837 | ochoa | Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2) | Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}. |
| Q8IWP9 | CCDC28A | S255 | ochoa | Coiled-coil domain-containing protein 28A (CCRL1AP) | None |
| Q8N1B4 | VPS52 | S352 | ochoa | Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. |
| Q8N4C8 | MINK1 | S903 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N7R7 | CCNYL1 | S121 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8NB90 | AFG2A | S274 | ochoa | ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q8NCG7 | DAGLB | S178 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
| Q8NDX5 | PHC3 | S318 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8TAA3 | PSMA8 | S209 | ochoa | Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. {ECO:0000250|UniProtKB:Q9CWH6}. |
| Q8TD55 | PLEKHO2 | S164 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8WVT3 | TRAPPC12 | S78 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q8WYP5 | AHCTF1 | S1533 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92794 | KAT6A | S974 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92859 | NEO1 | S1434 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q93077 | H2AC6 | T102 | ochoa | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96A49 | SYAP1 | S231 | ochoa | Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) | Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}. |
| Q96AQ6 | PBXIP1 | S67 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96DY7 | MTBP | S639 | ochoa | Mdm2-binding protein (hMTBP) | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}. |
| Q96F24 | NRBF2 | S120 | ochoa|psp | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}. |
| Q96H22 | CENPN | S299 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96KK5 | H2AC12 | T102 | ochoa | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96RL1 | UIMC1 | S463 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96TC7 | RMDN3 | S232 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99878 | H2AC14 | T102 | ochoa | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BYM8 | RBCK1 | S50 | ochoa | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9BYW2 | SETD2 | S676 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H4L7 | SMARCAD1 | S173 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H6S3 | EPS8L2 | S693 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H8V3 | ECT2 | S376 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H9C1 | VIPAS39 | S93 | ochoa | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
| Q9HCE1 | MOV10 | S815 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9HCH5 | SYTL2 | S322 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NQZ2 | UTP3 | S37 | ochoa | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}. |
| Q9NRY4 | ARHGAP35 | S770 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NUQ8 | ABCF3 | S79 | ochoa | ATP-binding cassette sub-family F member 3 | Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}. |
| Q9NVP2 | ASF1B | S169 | ochoa | Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904). {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:26527279}. |
| Q9NY74 | ETAA1 | S529 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZI7 | UBP1 | S393 | ochoa | Upstream-binding protein 1 (Transcription factor LBP-1) | Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:2006421, ECO:0000269|PubMed:8114710}. |
| Q9P0K7 | RAI14 | S341 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P270 | SLAIN2 | S179 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2D1 | CHD7 | S2490 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2J5 | LARS1 | S720 | ochoa | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q9UGU0 | TCF20 | S1675 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UIF8 | BAZ2B | S1465 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UKL3 | CASP8AP2 | S800 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9ULI4 | KIF26A | S1437 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULV3 | CIZ1 | S821 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMS6 | SYNPO2 | S88 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9Y2F5 | ICE1 | S1053 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2G0 | EFR3B | S693 | ochoa | Protein EFR3 homolog B | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}. |
| Q9Y2H2 | INPP5F | S942 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y3Z3 | SAMHD1 | S93 | ochoa | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}. |
| Q9Y446 | PKP3 | S80 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y520 | PRRC2C | S1100 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6I3 | EPN1 | S419 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6M5 | SLC30A1 | S197 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6Q9 | NCOA3 | S1062 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| A0A2R8Y4L2 | HNRNPA1L3 | S95 | Sugiyama | Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) | None |
| P84098 | RPL19 | S37 | Sugiyama | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P55039 | DRG2 | S72 | EPSD|PSP | Developmentally-regulated GTP-binding protein 2 (DRG-2) (Translation factor GTPase DRG2) (TRAFAC GTPase DRG2) (EC 3.6.5.-) | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. {ECO:0000269|PubMed:29915238}. |
| Q99613 | EIF3C | S638 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O43765 | SGTA | S197 | Sugiyama | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. |
| P13639 | EEF2 | S793 | Sugiyama | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P31327 | CPS1 | S759 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| O43283 | MAP3K13 | S684 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| P36871 | PGM1 | S485 | Sugiyama | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| O60566 | BUB1B | S985 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q12805 | EFEMP1 | S382 | Sugiyama | EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. {ECO:0000269|PubMed:19804359, ECO:0000269|PubMed:19887559, ECO:0000269|PubMed:20005202}. |
| P62277 | RPS13 | S21 | Sugiyama | Small ribosomal subunit protein uS15 (40S ribosomal protein S13) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P32119 | PRDX2 | S151 | Sugiyama | Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}. |
| P35606 | COPB2 | S195 | Sugiyama | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| Q04917 | YWHAH | S38 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P24046 | GABRR1 | S402 | iPTMNet | Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABAAR subunit rho-1) (GABA(C) receptor) | Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (PubMed:37659407). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:37659407). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (PubMed:1849271). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity). {ECO:0000250|UniProtKB:P56475, ECO:0000269|PubMed:1849271, ECO:0000269|PubMed:37659407}. |
| Q16512 | PKN1 | S297 | Sugiyama | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| P05023 | ATP1A1 | S675 | Sugiyama | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P15153 | RAC2 | S158 | Sugiyama | Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2) | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). {ECO:0000269|PubMed:1660188, ECO:0000269|PubMed:30723080}. |
| P60763 | RAC3 | S158 | Sugiyama | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}. |
| P63000 | RAC1 | S158 | Sugiyama | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:22843693, PubMed:23512198, PubMed:28886345). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:1643658). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity). Required for DSG3 translocation to cell-cell junctions, DSG3-mediated organization of cortical F-actin bundles and anchoring of actin at cell junctions; via interaction with DSG3 (PubMed:22796473). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:38355798). {ECO:0000250|UniProtKB:P63001, ECO:0000250|UniProtKB:Q6RUV5, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:22843693, ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:28886345, ECO:0000269|PubMed:38355798, ECO:0000269|PubMed:9121475}.; FUNCTION: [Isoform B]: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins (PubMed:14625275). It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction (PubMed:14625275). {ECO:0000269|PubMed:14625275}. |
| Q9H093 | NUAK2 | S573 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q9H093 | NUAK2 | S585 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q8IW41 | MAPKAPK5 | S160 | SIGNOR|PSP | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q6PIW4 | FIGNL1 | S616 | Sugiyama | Fidgetin-like protein 1 (EC 3.6.4.-) | Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.457159e-08 | 7.351 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.675030e-08 | 7.435 |
| R-HSA-1500931 | Cell-Cell communication | 4.236504e-08 | 7.373 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 1.102071e-07 | 6.958 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.300603e-07 | 6.886 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.510080e-07 | 6.600 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.510080e-07 | 6.600 |
| R-HSA-211000 | Gene Silencing by RNA | 2.960243e-07 | 6.529 |
| R-HSA-2559583 | Cellular Senescence | 3.921996e-07 | 6.406 |
| R-HSA-446728 | Cell junction organization | 6.574373e-07 | 6.182 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 7.694129e-07 | 6.114 |
| R-HSA-9609690 | HCMV Early Events | 1.016507e-06 | 5.993 |
| R-HSA-3214847 | HATs acetylate histones | 1.006240e-06 | 5.997 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.016507e-06 | 5.993 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.301640e-06 | 5.886 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.788863e-06 | 5.747 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.355393e-06 | 5.628 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.135614e-06 | 5.504 |
| R-HSA-418990 | Adherens junctions interactions | 3.464127e-06 | 5.460 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.160362e-06 | 5.287 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.607474e-06 | 5.251 |
| R-HSA-68875 | Mitotic Prophase | 6.480128e-06 | 5.188 |
| R-HSA-9764561 | Regulation of CDH1 Function | 7.021070e-06 | 5.154 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 7.870029e-06 | 5.104 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 7.833860e-06 | 5.106 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.169009e-05 | 4.932 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.169009e-05 | 4.932 |
| R-HSA-2262752 | Cellular responses to stress | 1.248830e-05 | 4.903 |
| R-HSA-9710421 | Defective pyroptosis | 1.326308e-05 | 4.877 |
| R-HSA-9609646 | HCMV Infection | 1.517669e-05 | 4.819 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.500616e-05 | 4.824 |
| R-HSA-9610379 | HCMV Late Events | 1.470932e-05 | 4.832 |
| R-HSA-421270 | Cell-cell junction organization | 1.583543e-05 | 4.800 |
| R-HSA-5334118 | DNA methylation | 1.623658e-05 | 4.790 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.693444e-05 | 4.771 |
| R-HSA-774815 | Nucleosome assembly | 1.693444e-05 | 4.771 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.756748e-05 | 4.755 |
| R-HSA-75153 | Apoptotic execution phase | 1.906298e-05 | 4.720 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.121655e-05 | 4.673 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.135261e-05 | 4.671 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.563134e-05 | 4.591 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.563451e-05 | 4.591 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.802648e-05 | 4.552 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.182887e-05 | 4.497 |
| R-HSA-912446 | Meiotic recombination | 3.329554e-05 | 4.478 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.698973e-05 | 4.432 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.101404e-05 | 4.387 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.898294e-05 | 4.409 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.898294e-05 | 4.409 |
| R-HSA-5689603 | UCH proteinases | 4.300149e-05 | 4.367 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.062369e-05 | 4.296 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.667140e-05 | 4.247 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 5.740461e-05 | 4.241 |
| R-HSA-110331 | Cleavage of the damaged purine | 5.740461e-05 | 4.241 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.420804e-05 | 4.266 |
| R-HSA-4839726 | Chromatin organization | 5.853725e-05 | 4.233 |
| R-HSA-73927 | Depurination | 6.489253e-05 | 4.188 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 8.043076e-05 | 4.095 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 8.220313e-05 | 4.085 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 9.213855e-05 | 4.036 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.120556e-04 | 3.951 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.148691e-04 | 3.940 |
| R-HSA-73928 | Depyrimidination | 1.148691e-04 | 3.940 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.329704e-04 | 3.876 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.349432e-04 | 3.870 |
| R-HSA-157118 | Signaling by NOTCH | 1.584870e-04 | 3.800 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.735959e-04 | 3.760 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.027482e-04 | 3.693 |
| R-HSA-162582 | Signal Transduction | 2.037654e-04 | 3.691 |
| R-HSA-73886 | Chromosome Maintenance | 2.127021e-04 | 3.672 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.212209e-04 | 3.655 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.329433e-04 | 3.633 |
| R-HSA-157579 | Telomere Maintenance | 2.376047e-04 | 3.624 |
| R-HSA-1640170 | Cell Cycle | 2.380178e-04 | 3.623 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.506944e-04 | 3.601 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.506944e-04 | 3.601 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.695547e-04 | 3.569 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.770056e-04 | 3.558 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.770056e-04 | 3.558 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.770056e-04 | 3.558 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.000897e-04 | 3.523 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.895205e-04 | 3.538 |
| R-HSA-70171 | Glycolysis | 2.849267e-04 | 3.545 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.184996e-04 | 3.497 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.184996e-04 | 3.497 |
| R-HSA-1221632 | Meiotic synapsis | 3.312034e-04 | 3.480 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.330158e-04 | 3.478 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.572016e-04 | 3.447 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.807472e-04 | 3.419 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.807472e-04 | 3.419 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.572016e-04 | 3.447 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.607254e-04 | 3.443 |
| R-HSA-68886 | M Phase | 3.828293e-04 | 3.417 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.993575e-04 | 3.399 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.451640e-04 | 3.351 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.013029e-04 | 3.300 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.206376e-04 | 3.283 |
| R-HSA-1500620 | Meiosis | 5.281641e-04 | 3.277 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.485347e-04 | 3.261 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.065121e-04 | 3.217 |
| R-HSA-373753 | Nephrin family interactions | 5.671637e-04 | 3.246 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.836774e-04 | 3.234 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.689659e-04 | 3.175 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 6.689659e-04 | 3.175 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.778746e-04 | 3.169 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 7.361118e-04 | 3.133 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 7.361118e-04 | 3.133 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 7.361118e-04 | 3.133 |
| R-HSA-397014 | Muscle contraction | 7.745871e-04 | 3.111 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 8.081689e-04 | 3.092 |
| R-HSA-70326 | Glucose metabolism | 8.351040e-04 | 3.078 |
| R-HSA-5688426 | Deubiquitination | 9.234398e-04 | 3.035 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 9.542076e-04 | 3.020 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.180141e-03 | 2.928 |
| R-HSA-195721 | Signaling by WNT | 1.030061e-03 | 2.987 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.177471e-03 | 2.929 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.227809e-03 | 2.911 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.249998e-03 | 2.903 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.255680e-03 | 2.901 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.356285e-03 | 2.868 |
| R-HSA-109581 | Apoptosis | 1.606777e-03 | 2.794 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.998999e-03 | 2.699 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.151199e-03 | 2.667 |
| R-HSA-977225 | Amyloid fiber formation | 2.274430e-03 | 2.643 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.296398e-03 | 2.639 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.386876e-03 | 2.622 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.402908e-03 | 2.619 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.470547e-03 | 2.607 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.676161e-03 | 2.572 |
| R-HSA-390522 | Striated Muscle Contraction | 3.130237e-03 | 2.504 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.972087e-03 | 2.527 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.972087e-03 | 2.527 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.419796e-03 | 2.466 |
| R-HSA-191859 | snRNP Assembly | 3.419796e-03 | 2.466 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.972087e-03 | 2.527 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.442016e-03 | 2.463 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.009143e-03 | 2.522 |
| R-HSA-168255 | Influenza Infection | 3.022736e-03 | 2.520 |
| R-HSA-73884 | Base Excision Repair | 3.818596e-03 | 2.418 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.869272e-03 | 2.412 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.109184e-03 | 2.386 |
| R-HSA-69306 | DNA Replication | 4.280113e-03 | 2.369 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.429262e-03 | 2.354 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.628119e-03 | 2.335 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 5.113025e-03 | 2.291 |
| R-HSA-8939211 | ESR-mediated signaling | 5.367128e-03 | 2.270 |
| R-HSA-69481 | G2/M Checkpoints | 5.595182e-03 | 2.252 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.758390e-03 | 2.240 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.565963e-03 | 2.183 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.490566e-03 | 2.125 |
| R-HSA-198753 | ERK/MAPK targets | 7.043953e-03 | 2.152 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 6.439856e-03 | 2.191 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.871609e-03 | 2.104 |
| R-HSA-1474165 | Reproduction | 6.471963e-03 | 2.189 |
| R-HSA-74160 | Gene expression (Transcription) | 6.903191e-03 | 2.161 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 7.043953e-03 | 2.152 |
| R-HSA-5357801 | Programmed Cell Death | 6.814155e-03 | 2.167 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.071993e-03 | 2.093 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.624760e-03 | 2.064 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.056144e-03 | 2.043 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.056144e-03 | 2.043 |
| R-HSA-597592 | Post-translational protein modification | 9.213702e-03 | 2.036 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 9.771577e-03 | 2.010 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 9.869618e-03 | 2.006 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.002572e-02 | 1.999 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.068846e-02 | 1.971 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.091895e-02 | 1.962 |
| R-HSA-199991 | Membrane Trafficking | 1.119148e-02 | 1.951 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.141604e-02 | 1.942 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.171019e-02 | 1.931 |
| R-HSA-9824446 | Viral Infection Pathways | 1.175650e-02 | 1.930 |
| R-HSA-196025 | Formation of annular gap junctions | 1.182757e-02 | 1.927 |
| R-HSA-525793 | Myogenesis | 1.231436e-02 | 1.910 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.298647e-02 | 1.887 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.303821e-02 | 1.885 |
| R-HSA-392499 | Metabolism of proteins | 1.377663e-02 | 1.861 |
| R-HSA-190873 | Gap junction degradation | 1.394079e-02 | 1.856 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.396144e-02 | 1.855 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.467162e-02 | 1.834 |
| R-HSA-1266738 | Developmental Biology | 1.489785e-02 | 1.827 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.560437e-02 | 1.807 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.562579e-02 | 1.806 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.594301e-02 | 1.797 |
| R-HSA-1474244 | Extracellular matrix organization | 1.629710e-02 | 1.788 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 2.116326e-02 | 1.674 |
| R-HSA-8873719 | RAB geranylgeranylation | 1.903707e-02 | 1.720 |
| R-HSA-194138 | Signaling by VEGF | 1.868335e-02 | 1.729 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.187548e-02 | 1.660 |
| R-HSA-8848021 | Signaling by PTK6 | 2.187548e-02 | 1.660 |
| R-HSA-9675108 | Nervous system development | 1.830873e-02 | 1.737 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.861341e-02 | 1.730 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 1.804618e-02 | 1.744 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.720359e-02 | 1.764 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.755127e-02 | 1.756 |
| R-HSA-422475 | Axon guidance | 2.217041e-02 | 1.654 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.369267e-02 | 1.625 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.666698e-02 | 1.574 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 2.666698e-02 | 1.574 |
| R-HSA-73894 | DNA Repair | 2.711069e-02 | 1.567 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.725410e-02 | 1.565 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.817307e-02 | 1.550 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.817307e-02 | 1.550 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.954168e-02 | 1.530 |
| R-HSA-8875878 | MET promotes cell motility | 2.982039e-02 | 1.525 |
| R-HSA-5663205 | Infectious disease | 3.072492e-02 | 1.513 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.151756e-02 | 1.501 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.249250e-02 | 1.488 |
| R-HSA-418885 | DCC mediated attractive signaling | 3.267982e-02 | 1.486 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 3.267982e-02 | 1.486 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 3.267982e-02 | 1.486 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3.267982e-02 | 1.486 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.313136e-02 | 1.480 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.394553e-02 | 1.469 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.394553e-02 | 1.469 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.506069e-02 | 1.455 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.690620e-02 | 1.433 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.690620e-02 | 1.433 |
| R-HSA-68877 | Mitotic Prometaphase | 3.959925e-02 | 1.402 |
| R-HSA-212436 | Generic Transcription Pathway | 4.038610e-02 | 1.394 |
| R-HSA-8854214 | TBC/RABGAPs | 4.074378e-02 | 1.390 |
| R-HSA-9907900 | Proteasome assembly | 4.273525e-02 | 1.369 |
| R-HSA-373752 | Netrin-1 signaling | 4.273525e-02 | 1.369 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.273525e-02 | 1.369 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.274356e-02 | 1.369 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 4.337489e-02 | 1.363 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.513837e-02 | 1.345 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.513837e-02 | 1.345 |
| R-HSA-373760 | L1CAM interactions | 4.513837e-02 | 1.345 |
| R-HSA-156711 | Polo-like kinase mediated events | 4.609816e-02 | 1.336 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 4.609816e-02 | 1.336 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.686185e-02 | 1.329 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.686185e-02 | 1.329 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.686185e-02 | 1.329 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.686185e-02 | 1.329 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.767701e-02 | 1.322 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.849978e-02 | 1.314 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.899625e-02 | 1.310 |
| R-HSA-437239 | Recycling pathway of L1 | 4.899625e-02 | 1.310 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 4.971957e-02 | 1.303 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.110986e-02 | 1.291 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.117751e-02 | 1.291 |
| R-HSA-70263 | Gluconeogenesis | 5.117751e-02 | 1.291 |
| R-HSA-3371556 | Cellular response to heat stress | 5.147046e-02 | 1.288 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 7.124542e-02 | 1.147 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 7.124542e-02 | 1.147 |
| R-HSA-72649 | Translation initiation complex formation | 6.522459e-02 | 1.186 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.026089e-02 | 1.153 |
| R-HSA-156902 | Peptide chain elongation | 5.703797e-02 | 1.244 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.414624e-02 | 1.193 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.365217e-02 | 1.133 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 7.546722e-02 | 1.122 |
| R-HSA-3000157 | Laminin interactions | 7.764511e-02 | 1.110 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.365217e-02 | 1.133 |
| R-HSA-6798695 | Neutrophil degranulation | 5.356791e-02 | 1.271 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.599269e-02 | 1.181 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 5.741272e-02 | 1.241 |
| R-HSA-417973 | Adenosine P1 receptors | 7.124542e-02 | 1.147 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.488071e-02 | 1.261 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 7.764511e-02 | 1.110 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.787470e-02 | 1.168 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.024742e-02 | 1.220 |
| R-HSA-114608 | Platelet degranulation | 6.116607e-02 | 1.213 |
| R-HSA-177929 | Signaling by EGFR | 7.026089e-02 | 1.153 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.182793e-02 | 1.144 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.994664e-02 | 1.155 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 7.026089e-02 | 1.153 |
| R-HSA-8863678 | Neurodegenerative Diseases | 7.340394e-02 | 1.134 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 7.340394e-02 | 1.134 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.255165e-02 | 1.139 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.817620e-02 | 1.107 |
| R-HSA-913531 | Interferon Signaling | 7.933660e-02 | 1.101 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.967999e-02 | 1.099 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.967999e-02 | 1.099 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.967999e-02 | 1.099 |
| R-HSA-1643685 | Disease | 8.135572e-02 | 1.090 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.174233e-02 | 1.088 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 8.196149e-02 | 1.086 |
| R-HSA-70635 | Urea cycle | 8.196149e-02 | 1.086 |
| R-HSA-8874081 | MET activates PTK2 signaling | 8.196149e-02 | 1.086 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 8.196149e-02 | 1.086 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 8.196149e-02 | 1.086 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 8.196149e-02 | 1.086 |
| R-HSA-450294 | MAP kinase activation | 8.358567e-02 | 1.078 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 8.487595e-02 | 1.071 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 8.487595e-02 | 1.071 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 8.487595e-02 | 1.071 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.517986e-02 | 1.070 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.517986e-02 | 1.070 |
| R-HSA-9664407 | Parasite infection | 8.517986e-02 | 1.070 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 8.634998e-02 | 1.064 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 8.634998e-02 | 1.064 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 8.634998e-02 | 1.064 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 8.634998e-02 | 1.064 |
| R-HSA-9707616 | Heme signaling | 8.637189e-02 | 1.064 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.693496e-02 | 1.061 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 1.115423e-01 | 0.953 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 1.115423e-01 | 0.953 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.115423e-01 | 0.953 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 1.115423e-01 | 0.953 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.245838e-01 | 0.905 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.374347e-01 | 0.862 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.374347e-01 | 0.862 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.500978e-01 | 0.824 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.500978e-01 | 0.824 |
| R-HSA-68952 | DNA replication initiation | 1.748711e-01 | 0.757 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.748711e-01 | 0.757 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 9.533128e-02 | 1.021 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.358338e-01 | 0.867 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.132769e-01 | 0.946 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.132769e-01 | 0.946 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.391974e-01 | 0.856 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 9.496235e-02 | 1.022 |
| R-HSA-68962 | Activation of the pre-replicative complex | 9.991826e-02 | 1.000 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.188436e-01 | 0.925 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.140310e-01 | 0.943 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.625757e-01 | 0.789 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.237060e-01 | 0.908 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.181672e-01 | 0.928 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.245838e-01 | 0.905 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.460083e-01 | 0.836 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.114362e-01 | 0.953 |
| R-HSA-5693538 | Homology Directed Repair | 1.333723e-01 | 0.875 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.599460e-01 | 0.796 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 9.830727e-02 | 1.007 |
| R-HSA-187024 | NGF-independant TRKA activation | 1.115423e-01 | 0.953 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.115423e-01 | 0.953 |
| R-HSA-199920 | CREB phosphorylation | 1.245838e-01 | 0.905 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.245838e-01 | 0.905 |
| R-HSA-426048 | Arachidonate production from DAG | 1.748711e-01 | 0.757 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.748711e-01 | 0.757 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.641158e-01 | 0.785 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.594868e-01 | 0.797 |
| R-HSA-182971 | EGFR downregulation | 1.045657e-01 | 0.981 |
| R-HSA-9733709 | Cardiogenesis | 1.140310e-01 | 0.943 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.188436e-01 | 0.925 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.245838e-01 | 0.905 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.688473e-02 | 1.014 |
| R-HSA-187015 | Activation of TRKA receptors | 1.374347e-01 | 0.862 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.374347e-01 | 0.862 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.625757e-01 | 0.789 |
| R-HSA-68882 | Mitotic Anaphase | 1.393369e-01 | 0.856 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.412852e-01 | 0.850 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.830727e-02 | 1.007 |
| R-HSA-164944 | Nef and signal transduction | 1.245838e-01 | 0.905 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.374347e-01 | 0.862 |
| R-HSA-448706 | Interleukin-1 processing | 1.625757e-01 | 0.789 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.748711e-01 | 0.757 |
| R-HSA-73887 | Death Receptor Signaling | 1.134469e-01 | 0.945 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.374347e-01 | 0.862 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.625757e-01 | 0.789 |
| R-HSA-9659379 | Sensory processing of sound | 1.391974e-01 | 0.856 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 9.830727e-02 | 1.007 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.500978e-01 | 0.824 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.188436e-01 | 0.925 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.038875e-01 | 0.983 |
| R-HSA-448424 | Interleukin-17 signaling | 1.100152e-01 | 0.959 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.037759e-01 | 0.984 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.335707e-01 | 0.874 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.140310e-01 | 0.943 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.061156e-01 | 0.974 |
| R-HSA-114452 | Activation of BH3-only proteins | 9.991826e-02 | 1.000 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.084792e-01 | 0.965 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.359816e-01 | 0.867 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.162789e-01 | 0.934 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.084792e-01 | 0.965 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.359816e-01 | 0.867 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.439324e-01 | 0.842 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 9.690242e-02 | 1.014 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.625757e-01 | 0.789 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.439324e-01 | 0.842 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.157106e-01 | 0.937 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.412619e-01 | 0.850 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.231480e-01 | 0.910 |
| R-HSA-9931953 | Biofilm formation | 1.436058e-01 | 0.843 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.055098e-01 | 0.977 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.307841e-01 | 0.883 |
| R-HSA-1483255 | PI Metabolism | 8.808601e-02 | 1.055 |
| R-HSA-9008059 | Interleukin-37 signaling | 9.991826e-02 | 1.000 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.631651e-01 | 0.787 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.358338e-01 | 0.867 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 9.916907e-02 | 1.004 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.460083e-01 | 0.836 |
| R-HSA-166520 | Signaling by NTRKs | 1.016482e-01 | 0.993 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.131303e-01 | 0.946 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.092708e-01 | 0.961 |
| R-HSA-168256 | Immune System | 1.438840e-01 | 0.842 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.226734e-01 | 0.911 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 9.050173e-02 | 1.043 |
| R-HSA-4086400 | PCP/CE pathway | 1.358338e-01 | 0.867 |
| R-HSA-6806834 | Signaling by MET | 1.425892e-01 | 0.846 |
| R-HSA-162906 | HIV Infection | 1.614482e-01 | 0.792 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 9.050173e-02 | 1.043 |
| R-HSA-72306 | tRNA processing | 1.501856e-01 | 0.823 |
| R-HSA-162587 | HIV Life Cycle | 1.195831e-01 | 0.922 |
| R-HSA-5619102 | SLC transporter disorders | 1.411240e-01 | 0.850 |
| R-HSA-190828 | Gap junction trafficking | 1.798170e-01 | 0.745 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.798170e-01 | 0.745 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.826440e-01 | 0.738 |
| R-HSA-9824272 | Somitogenesis | 1.851010e-01 | 0.733 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.851010e-01 | 0.733 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.852409e-01 | 0.732 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.855459e-01 | 0.732 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.869868e-01 | 0.728 |
| R-HSA-4839744 | Signaling by APC mutants | 1.869868e-01 | 0.728 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.869868e-01 | 0.728 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.869868e-01 | 0.728 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.869868e-01 | 0.728 |
| R-HSA-192905 | vRNP Assembly | 1.869868e-01 | 0.728 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.869868e-01 | 0.728 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 1.869868e-01 | 0.728 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.904071e-01 | 0.720 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.921241e-01 | 0.716 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.926541e-01 | 0.715 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.989254e-01 | 0.701 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.989254e-01 | 0.701 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.989254e-01 | 0.701 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.989254e-01 | 0.701 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.989254e-01 | 0.701 |
| R-HSA-428540 | Activation of RAC1 | 1.989254e-01 | 0.701 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.001406e-01 | 0.699 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.039098e-01 | 0.691 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.064400e-01 | 0.685 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.064400e-01 | 0.685 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.106893e-01 | 0.676 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.106893e-01 | 0.676 |
| R-HSA-69109 | Leading Strand Synthesis | 2.106893e-01 | 0.676 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.106893e-01 | 0.676 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.106893e-01 | 0.676 |
| R-HSA-69091 | Polymerase switching | 2.106893e-01 | 0.676 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.106893e-01 | 0.676 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.106893e-01 | 0.676 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.106893e-01 | 0.676 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.106893e-01 | 0.676 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.106893e-01 | 0.676 |
| R-HSA-4641265 | Repression of WNT target genes | 2.106893e-01 | 0.676 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.106893e-01 | 0.676 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.114969e-01 | 0.675 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.222812e-01 | 0.653 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.222812e-01 | 0.653 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.226104e-01 | 0.652 |
| R-HSA-72766 | Translation | 2.242930e-01 | 0.649 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.280237e-01 | 0.642 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.307210e-01 | 0.637 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.319192e-01 | 0.635 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.337036e-01 | 0.631 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.337036e-01 | 0.631 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.337036e-01 | 0.631 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.337036e-01 | 0.631 |
| R-HSA-435354 | Zinc transporters | 2.337036e-01 | 0.631 |
| R-HSA-192823 | Viral mRNA Translation | 2.385005e-01 | 0.623 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.399610e-01 | 0.620 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.413828e-01 | 0.617 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.424073e-01 | 0.615 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.443126e-01 | 0.612 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 2.443126e-01 | 0.612 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.445572e-01 | 0.612 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.449589e-01 | 0.611 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.449589e-01 | 0.611 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.449589e-01 | 0.611 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.449589e-01 | 0.611 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.449589e-01 | 0.611 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.449589e-01 | 0.611 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.449589e-01 | 0.611 |
| R-HSA-8876725 | Protein methylation | 2.449589e-01 | 0.611 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.550323e-01 | 0.593 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.560495e-01 | 0.592 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.560495e-01 | 0.592 |
| R-HSA-9664420 | Killing mechanisms | 2.560495e-01 | 0.592 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.560495e-01 | 0.592 |
| R-HSA-5635838 | Activation of SMO | 2.560495e-01 | 0.592 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.560495e-01 | 0.592 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.581339e-01 | 0.588 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.606464e-01 | 0.584 |
| R-HSA-180786 | Extension of Telomeres | 2.606464e-01 | 0.584 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.669780e-01 | 0.574 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.669780e-01 | 0.574 |
| R-HSA-5576893 | Phase 2 - plateau phase | 2.669780e-01 | 0.574 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.669780e-01 | 0.574 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.669780e-01 | 0.574 |
| R-HSA-70370 | Galactose catabolism | 2.669780e-01 | 0.574 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.675459e-01 | 0.573 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.715434e-01 | 0.566 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.735901e-01 | 0.563 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 2.769907e-01 | 0.558 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 2.769907e-01 | 0.558 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.777465e-01 | 0.556 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.777465e-01 | 0.556 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.824356e-01 | 0.549 |
| R-HSA-373755 | Semaphorin interactions | 2.824356e-01 | 0.549 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.832979e-01 | 0.548 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.874453e-01 | 0.541 |
| R-HSA-9658195 | Leishmania infection | 2.874453e-01 | 0.541 |
| R-HSA-3928664 | Ephrin signaling | 2.883575e-01 | 0.540 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.883575e-01 | 0.540 |
| R-HSA-180292 | GAB1 signalosome | 2.883575e-01 | 0.540 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 2.883575e-01 | 0.540 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.933139e-01 | 0.533 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.988133e-01 | 0.525 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.988133e-01 | 0.525 |
| R-HSA-500753 | Pyrimidine biosynthesis | 2.988133e-01 | 0.525 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.988133e-01 | 0.525 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.041700e-01 | 0.517 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.041700e-01 | 0.517 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.063181e-01 | 0.514 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.091161e-01 | 0.510 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.091161e-01 | 0.510 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.091161e-01 | 0.510 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.091161e-01 | 0.510 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.091161e-01 | 0.510 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.091161e-01 | 0.510 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.091161e-01 | 0.510 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 3.091161e-01 | 0.510 |
| R-HSA-445144 | Signal transduction by L1 | 3.091161e-01 | 0.510 |
| R-HSA-9629569 | Protein hydroxylation | 3.091161e-01 | 0.510 |
| R-HSA-3322077 | Glycogen synthesis | 3.091161e-01 | 0.510 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.149960e-01 | 0.502 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.192681e-01 | 0.496 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.192681e-01 | 0.496 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.192681e-01 | 0.496 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.192681e-01 | 0.496 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 3.192681e-01 | 0.496 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.203954e-01 | 0.494 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.228826e-01 | 0.491 |
| R-HSA-3000178 | ECM proteoglycans | 3.257844e-01 | 0.487 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.292716e-01 | 0.482 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.292716e-01 | 0.482 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.292716e-01 | 0.482 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.311624e-01 | 0.480 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.311624e-01 | 0.480 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.391287e-01 | 0.470 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.391287e-01 | 0.470 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.391287e-01 | 0.470 |
| R-HSA-8852135 | Protein ubiquitination | 3.472212e-01 | 0.459 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 3.472212e-01 | 0.459 |
| R-HSA-9679506 | SARS-CoV Infections | 3.475628e-01 | 0.459 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 3.488415e-01 | 0.457 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.488415e-01 | 0.457 |
| R-HSA-3000170 | Syndecan interactions | 3.488415e-01 | 0.457 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.488415e-01 | 0.457 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.525465e-01 | 0.453 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.525465e-01 | 0.453 |
| R-HSA-429947 | Deadenylation of mRNA | 3.584122e-01 | 0.446 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.584122e-01 | 0.446 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.584122e-01 | 0.446 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.584122e-01 | 0.446 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.605650e-01 | 0.443 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.661636e-01 | 0.436 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.678427e-01 | 0.434 |
| R-HSA-9839394 | TGFBR3 expression | 3.678427e-01 | 0.434 |
| R-HSA-9620244 | Long-term potentiation | 3.678427e-01 | 0.434 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 3.678427e-01 | 0.434 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.678427e-01 | 0.434 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.678427e-01 | 0.434 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.678427e-01 | 0.434 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.678427e-01 | 0.434 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.678427e-01 | 0.434 |
| R-HSA-9843745 | Adipogenesis | 3.701522e-01 | 0.432 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.736905e-01 | 0.427 |
| R-HSA-9909396 | Circadian clock | 3.741417e-01 | 0.427 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.761529e-01 | 0.425 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.771353e-01 | 0.424 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.771353e-01 | 0.424 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.771353e-01 | 0.424 |
| R-HSA-3295583 | TRP channels | 3.771353e-01 | 0.424 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 3.771353e-01 | 0.424 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.771353e-01 | 0.424 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.771353e-01 | 0.424 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.862918e-01 | 0.413 |
| R-HSA-8949613 | Cristae formation | 3.862918e-01 | 0.413 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.862918e-01 | 0.413 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.862918e-01 | 0.413 |
| R-HSA-201451 | Signaling by BMP | 3.862918e-01 | 0.413 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.862918e-01 | 0.413 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.862918e-01 | 0.413 |
| R-HSA-8953854 | Metabolism of RNA | 3.876243e-01 | 0.412 |
| R-HSA-163685 | Integration of energy metabolism | 3.940096e-01 | 0.404 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.953142e-01 | 0.403 |
| R-HSA-622312 | Inflammasomes | 3.953142e-01 | 0.403 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.979648e-01 | 0.400 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.019131e-01 | 0.396 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.042046e-01 | 0.393 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.042046e-01 | 0.393 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.060179e-01 | 0.391 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.099892e-01 | 0.387 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.099892e-01 | 0.387 |
| R-HSA-109582 | Hemostasis | 4.120173e-01 | 0.385 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.129648e-01 | 0.384 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.129648e-01 | 0.384 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.129648e-01 | 0.384 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.129648e-01 | 0.384 |
| R-HSA-2424491 | DAP12 signaling | 4.129648e-01 | 0.384 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.129648e-01 | 0.384 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.150926e-01 | 0.382 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.150926e-01 | 0.382 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.215967e-01 | 0.375 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 4.215967e-01 | 0.375 |
| R-HSA-69190 | DNA strand elongation | 4.301022e-01 | 0.366 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.301022e-01 | 0.366 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.302687e-01 | 0.366 |
| R-HSA-168249 | Innate Immune System | 4.364703e-01 | 0.360 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.384831e-01 | 0.358 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.384831e-01 | 0.358 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.384831e-01 | 0.358 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.384831e-01 | 0.358 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.384831e-01 | 0.358 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.384831e-01 | 0.358 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.384831e-01 | 0.358 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.384831e-01 | 0.358 |
| R-HSA-159418 | Recycling of bile acids and salts | 4.384831e-01 | 0.358 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 4.384831e-01 | 0.358 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.467414e-01 | 0.350 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.467414e-01 | 0.350 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.548786e-01 | 0.342 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.548786e-01 | 0.342 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.548786e-01 | 0.342 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.550907e-01 | 0.342 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.601041e-01 | 0.337 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.628967e-01 | 0.335 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.628967e-01 | 0.335 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.628967e-01 | 0.335 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.628967e-01 | 0.335 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.648456e-01 | 0.333 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.696846e-01 | 0.328 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.707973e-01 | 0.327 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.707973e-01 | 0.327 |
| R-HSA-1989781 | PPARA activates gene expression | 4.714633e-01 | 0.327 |
| R-HSA-419037 | NCAM1 interactions | 4.785822e-01 | 0.320 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.785822e-01 | 0.320 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.789764e-01 | 0.320 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.792839e-01 | 0.319 |
| R-HSA-9711097 | Cellular response to starvation | 4.827143e-01 | 0.316 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.862531e-01 | 0.313 |
| R-HSA-1566948 | Elastic fibre formation | 4.862531e-01 | 0.313 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.862531e-01 | 0.313 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.901520e-01 | 0.310 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.938115e-01 | 0.306 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.981609e-01 | 0.303 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.012593e-01 | 0.300 |
| R-HSA-5260271 | Diseases of Immune System | 5.012593e-01 | 0.300 |
| R-HSA-8982491 | Glycogen metabolism | 5.012593e-01 | 0.300 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.085979e-01 | 0.294 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.085979e-01 | 0.294 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.085979e-01 | 0.294 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.085979e-01 | 0.294 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.085979e-01 | 0.294 |
| R-HSA-9607240 | FLT3 Signaling | 5.085979e-01 | 0.294 |
| R-HSA-72312 | rRNA processing | 5.121406e-01 | 0.291 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.158289e-01 | 0.287 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.158289e-01 | 0.287 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.229540e-01 | 0.282 |
| R-HSA-165159 | MTOR signalling | 5.229540e-01 | 0.282 |
| R-HSA-69239 | Synthesis of DNA | 5.256462e-01 | 0.279 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.299747e-01 | 0.276 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.299747e-01 | 0.276 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.301278e-01 | 0.276 |
| R-HSA-5683826 | Surfactant metabolism | 5.368925e-01 | 0.270 |
| R-HSA-2172127 | DAP12 interactions | 5.368925e-01 | 0.270 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.437089e-01 | 0.265 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 5.504253e-01 | 0.259 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.504253e-01 | 0.259 |
| R-HSA-9675135 | Diseases of DNA repair | 5.504253e-01 | 0.259 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.504253e-01 | 0.259 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.504253e-01 | 0.259 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.570434e-01 | 0.254 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.570434e-01 | 0.254 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.606887e-01 | 0.251 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.635644e-01 | 0.249 |
| R-HSA-5620924 | Intraflagellar transport | 5.635644e-01 | 0.249 |
| R-HSA-425410 | Metal ion SLC transporters | 5.635644e-01 | 0.249 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.691569e-01 | 0.245 |
| R-HSA-9766229 | Degradation of CDH1 | 5.699898e-01 | 0.244 |
| R-HSA-9748787 | Azathioprine ADME | 5.763210e-01 | 0.239 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.816377e-01 | 0.235 |
| R-HSA-69275 | G2/M Transition | 5.849325e-01 | 0.233 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.887062e-01 | 0.230 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.887062e-01 | 0.230 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.887062e-01 | 0.230 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.887062e-01 | 0.230 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.887062e-01 | 0.230 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.887062e-01 | 0.230 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.914973e-01 | 0.228 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.947630e-01 | 0.226 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.947630e-01 | 0.226 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.947630e-01 | 0.226 |
| R-HSA-5617833 | Cilium Assembly | 5.979951e-01 | 0.223 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.007309e-01 | 0.221 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.018462e-01 | 0.221 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.033376e-01 | 0.219 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.066113e-01 | 0.217 |
| R-HSA-9012852 | Signaling by NOTCH3 | 6.066113e-01 | 0.217 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.107881e-01 | 0.214 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.124054e-01 | 0.213 |
| R-HSA-75893 | TNF signaling | 6.124054e-01 | 0.213 |
| R-HSA-5578775 | Ion homeostasis | 6.124054e-01 | 0.213 |
| R-HSA-69206 | G1/S Transition | 6.136151e-01 | 0.212 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.237400e-01 | 0.205 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.292829e-01 | 0.201 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 6.292829e-01 | 0.201 |
| R-HSA-186712 | Regulation of beta-cell development | 6.292829e-01 | 0.201 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.292829e-01 | 0.201 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.326377e-01 | 0.199 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.347445e-01 | 0.197 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.347445e-01 | 0.197 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.347445e-01 | 0.197 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.347445e-01 | 0.197 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.347445e-01 | 0.197 |
| R-HSA-379724 | tRNA Aminoacylation | 6.347445e-01 | 0.197 |
| R-HSA-983189 | Kinesins | 6.347445e-01 | 0.197 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.347445e-01 | 0.197 |
| R-HSA-977443 | GABA receptor activation | 6.347445e-01 | 0.197 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.347445e-01 | 0.197 |
| R-HSA-351202 | Metabolism of polyamines | 6.347445e-01 | 0.197 |
| R-HSA-5576891 | Cardiac conduction | 6.400403e-01 | 0.194 |
| R-HSA-211976 | Endogenous sterols | 6.401259e-01 | 0.194 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.436976e-01 | 0.191 |
| R-HSA-72172 | mRNA Splicing | 6.445515e-01 | 0.191 |
| R-HSA-1268020 | Mitochondrial protein import | 6.454284e-01 | 0.190 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.454284e-01 | 0.190 |
| R-HSA-186797 | Signaling by PDGF | 6.454284e-01 | 0.190 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.506531e-01 | 0.187 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.506531e-01 | 0.187 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.506531e-01 | 0.187 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.558011e-01 | 0.183 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.558011e-01 | 0.183 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.658716e-01 | 0.177 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.677828e-01 | 0.175 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.707963e-01 | 0.173 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.707963e-01 | 0.173 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.713822e-01 | 0.173 |
| R-HSA-6807070 | PTEN Regulation | 6.719085e-01 | 0.173 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.851408e-01 | 0.164 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.851408e-01 | 0.164 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.858967e-01 | 0.164 |
| R-HSA-1483257 | Phospholipid metabolism | 6.858967e-01 | 0.164 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.882717e-01 | 0.162 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.897826e-01 | 0.161 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.897826e-01 | 0.161 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 6.897826e-01 | 0.161 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.897826e-01 | 0.161 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.943563e-01 | 0.158 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.982893e-01 | 0.156 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.988628e-01 | 0.156 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.988628e-01 | 0.156 |
| R-HSA-4086398 | Ca2+ pathway | 6.988628e-01 | 0.156 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.033031e-01 | 0.153 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.033031e-01 | 0.153 |
| R-HSA-69242 | S Phase | 7.046048e-01 | 0.152 |
| R-HSA-380287 | Centrosome maturation | 7.076783e-01 | 0.150 |
| R-HSA-9758941 | Gastrulation | 7.077213e-01 | 0.150 |
| R-HSA-1280218 | Adaptive Immune System | 7.144703e-01 | 0.146 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 7.162368e-01 | 0.145 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.169069e-01 | 0.145 |
| R-HSA-9609507 | Protein localization | 7.199146e-01 | 0.143 |
| R-HSA-191273 | Cholesterol biosynthesis | 7.204220e-01 | 0.142 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.286088e-01 | 0.138 |
| R-HSA-9833482 | PKR-mediated signaling | 7.286088e-01 | 0.138 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.286088e-01 | 0.138 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.402250e-01 | 0.131 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.404436e-01 | 0.131 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.404436e-01 | 0.131 |
| R-HSA-449147 | Signaling by Interleukins | 7.416050e-01 | 0.130 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 7.442732e-01 | 0.128 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.442732e-01 | 0.128 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 7.480466e-01 | 0.126 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.517644e-01 | 0.124 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.554277e-01 | 0.122 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.590371e-01 | 0.120 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.625935e-01 | 0.118 |
| R-HSA-1236974 | ER-Phagosome pathway | 7.660976e-01 | 0.116 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.721244e-01 | 0.112 |
| R-HSA-391251 | Protein folding | 7.796063e-01 | 0.108 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.839846e-01 | 0.106 |
| R-HSA-1474290 | Collagen formation | 7.860665e-01 | 0.105 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.892255e-01 | 0.103 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.954048e-01 | 0.099 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.954048e-01 | 0.099 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.954048e-01 | 0.099 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.984265e-01 | 0.098 |
| R-HSA-5368286 | Mitochondrial translation initiation | 8.014037e-01 | 0.096 |
| R-HSA-422356 | Regulation of insulin secretion | 8.014037e-01 | 0.096 |
| R-HSA-190236 | Signaling by FGFR | 8.014037e-01 | 0.096 |
| R-HSA-3781865 | Diseases of glycosylation | 8.027888e-01 | 0.095 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.043372e-01 | 0.095 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.043372e-01 | 0.095 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.100752e-01 | 0.091 |
| R-HSA-983712 | Ion channel transport | 8.135766e-01 | 0.090 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 8.156457e-01 | 0.088 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.183696e-01 | 0.087 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.183696e-01 | 0.087 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.236978e-01 | 0.084 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.313996e-01 | 0.080 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.313996e-01 | 0.080 |
| R-HSA-5419276 | Mitochondrial translation termination | 8.338917e-01 | 0.079 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.361631e-01 | 0.078 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.363471e-01 | 0.078 |
| R-HSA-9640148 | Infection with Enterobacteria | 8.410367e-01 | 0.075 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.411500e-01 | 0.075 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.458125e-01 | 0.073 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.587208e-01 | 0.066 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.651633e-01 | 0.063 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.691237e-01 | 0.061 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.710602e-01 | 0.060 |
| R-HSA-8956319 | Nucleotide catabolism | 8.820946e-01 | 0.054 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.837325e-01 | 0.054 |
| R-HSA-8957322 | Metabolism of steroids | 8.849175e-01 | 0.053 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.889231e-01 | 0.051 |
| R-HSA-15869 | Metabolism of nucleotides | 8.931300e-01 | 0.049 |
| R-HSA-5368287 | Mitochondrial translation | 8.999389e-01 | 0.046 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.999389e-01 | 0.046 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 9.138147e-01 | 0.039 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.175909e-01 | 0.037 |
| R-HSA-112316 | Neuronal System | 9.322824e-01 | 0.030 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.360786e-01 | 0.029 |
| R-HSA-418555 | G alpha (s) signalling events | 9.406837e-01 | 0.027 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.476623e-01 | 0.023 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.627077e-01 | 0.017 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.632624e-01 | 0.016 |
| R-HSA-6805567 | Keratinization | 9.654002e-01 | 0.015 |
| R-HSA-9748784 | Drug ADME | 9.710984e-01 | 0.013 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.754964e-01 | 0.011 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.831545e-01 | 0.007 |
| R-HSA-416476 | G alpha (q) signalling events | 9.855192e-01 | 0.006 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.882706e-01 | 0.005 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.889564e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.905308e-01 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 9.921190e-01 | 0.003 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.954664e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.968339e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.979989e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.983572e-01 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.986920e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.992412e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.997073e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.997196e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.998980e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999904e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999991e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.837 | 0.360 | -3 | 0.839 |
PRKD2 |
0.831 | 0.254 | -3 | 0.813 |
CLK3 |
0.831 | 0.114 | 1 | 0.892 |
COT |
0.827 | -0.027 | 2 | 0.772 |
CDC7 |
0.825 | 0.058 | 1 | 0.821 |
CAMK1B |
0.825 | 0.150 | -3 | 0.876 |
NUAK2 |
0.824 | 0.164 | -3 | 0.864 |
TSSK1 |
0.824 | 0.297 | -3 | 0.879 |
TSSK2 |
0.823 | 0.307 | -5 | 0.613 |
PIM3 |
0.823 | 0.040 | -3 | 0.855 |
NDR2 |
0.822 | 0.047 | -3 | 0.843 |
MOS |
0.822 | 0.055 | 1 | 0.854 |
PRKD3 |
0.820 | 0.269 | -3 | 0.796 |
CDKL1 |
0.820 | 0.089 | -3 | 0.833 |
HIPK4 |
0.819 | 0.124 | 1 | 0.847 |
PIM1 |
0.819 | 0.103 | -3 | 0.823 |
SRPK1 |
0.819 | 0.097 | -3 | 0.805 |
MAPKAPK2 |
0.819 | 0.150 | -3 | 0.774 |
NLK |
0.818 | 0.081 | 1 | 0.876 |
PRPK |
0.818 | -0.083 | -1 | 0.860 |
RSK2 |
0.818 | 0.089 | -3 | 0.817 |
KIS |
0.817 | 0.113 | 1 | 0.783 |
MAPKAPK3 |
0.816 | 0.136 | -3 | 0.805 |
CDKL5 |
0.816 | 0.095 | -3 | 0.826 |
PKN3 |
0.816 | 0.075 | -3 | 0.842 |
AMPKA1 |
0.815 | 0.138 | -3 | 0.864 |
ATR |
0.815 | 0.003 | 1 | 0.830 |
ERK5 |
0.815 | 0.064 | 1 | 0.844 |
CHK1 |
0.814 | 0.286 | -3 | 0.825 |
NUAK1 |
0.813 | 0.169 | -3 | 0.819 |
ICK |
0.813 | 0.105 | -3 | 0.856 |
MST4 |
0.813 | 0.055 | 2 | 0.825 |
P90RSK |
0.813 | 0.079 | -3 | 0.815 |
RAF1 |
0.812 | -0.068 | 1 | 0.821 |
BMPR2 |
0.812 | -0.073 | -2 | 0.905 |
CAMK2G |
0.812 | -0.041 | 2 | 0.717 |
CAMK2D |
0.812 | 0.102 | -3 | 0.843 |
IKKB |
0.812 | -0.076 | -2 | 0.785 |
LATS2 |
0.811 | 0.019 | -5 | 0.359 |
NIK |
0.811 | 0.063 | -3 | 0.874 |
WNK1 |
0.811 | 0.046 | -2 | 0.884 |
PDHK4 |
0.811 | -0.119 | 1 | 0.837 |
NDR1 |
0.811 | 0.004 | -3 | 0.847 |
PKN2 |
0.811 | 0.067 | -3 | 0.851 |
AMPKA2 |
0.810 | 0.126 | -3 | 0.840 |
CAMK2B |
0.810 | 0.110 | 2 | 0.709 |
DSTYK |
0.809 | -0.071 | 2 | 0.788 |
PDHK1 |
0.809 | -0.036 | 1 | 0.827 |
MTOR |
0.809 | -0.104 | 1 | 0.792 |
MARK4 |
0.809 | 0.055 | 4 | 0.867 |
CAMLCK |
0.809 | 0.033 | -2 | 0.875 |
SKMLCK |
0.809 | 0.007 | -2 | 0.876 |
CAMK2A |
0.809 | 0.116 | 2 | 0.711 |
RSK3 |
0.808 | 0.053 | -3 | 0.813 |
SRPK2 |
0.808 | 0.075 | -3 | 0.736 |
BMPR1B |
0.807 | 0.094 | 1 | 0.778 |
TBK1 |
0.807 | -0.081 | 1 | 0.716 |
DAPK2 |
0.807 | 0.041 | -3 | 0.870 |
TGFBR2 |
0.807 | 0.014 | -2 | 0.828 |
CDK8 |
0.807 | 0.087 | 1 | 0.757 |
P70S6KB |
0.807 | 0.028 | -3 | 0.828 |
GCN2 |
0.807 | -0.128 | 2 | 0.718 |
NEK6 |
0.806 | -0.027 | -2 | 0.874 |
GRK5 |
0.806 | -0.069 | -3 | 0.827 |
GRK6 |
0.806 | -0.003 | 1 | 0.812 |
PKCD |
0.805 | 0.022 | 2 | 0.694 |
IKKA |
0.805 | -0.022 | -2 | 0.777 |
FAM20C |
0.804 | 0.025 | 2 | 0.538 |
AURC |
0.804 | 0.063 | -2 | 0.695 |
CLK1 |
0.804 | 0.108 | -3 | 0.800 |
DYRK2 |
0.804 | 0.095 | 1 | 0.774 |
CLK4 |
0.803 | 0.095 | -3 | 0.815 |
CAMK4 |
0.803 | 0.078 | -3 | 0.833 |
RIPK3 |
0.803 | -0.063 | 3 | 0.719 |
MLK1 |
0.803 | -0.091 | 2 | 0.731 |
CDK18 |
0.803 | 0.116 | 1 | 0.702 |
ULK2 |
0.802 | -0.144 | 2 | 0.685 |
GRK1 |
0.802 | -0.010 | -2 | 0.818 |
NEK7 |
0.802 | -0.098 | -3 | 0.787 |
SRPK3 |
0.801 | 0.054 | -3 | 0.774 |
PKACG |
0.801 | 0.018 | -2 | 0.788 |
HIPK2 |
0.801 | 0.130 | 1 | 0.702 |
HUNK |
0.801 | -0.059 | 2 | 0.703 |
QSK |
0.801 | 0.095 | 4 | 0.850 |
IKKE |
0.801 | -0.109 | 1 | 0.710 |
CDK19 |
0.801 | 0.086 | 1 | 0.723 |
CDK1 |
0.801 | 0.089 | 1 | 0.725 |
MELK |
0.801 | 0.110 | -3 | 0.827 |
ATM |
0.800 | 0.002 | 1 | 0.765 |
RSK4 |
0.800 | 0.049 | -3 | 0.782 |
P38A |
0.800 | 0.117 | 1 | 0.787 |
CDK7 |
0.800 | 0.076 | 1 | 0.765 |
HIPK1 |
0.800 | 0.120 | 1 | 0.792 |
SIK |
0.799 | 0.104 | -3 | 0.793 |
BUB1 |
0.799 | 0.395 | -5 | 0.675 |
ALK4 |
0.799 | 0.034 | -2 | 0.871 |
LATS1 |
0.799 | 0.012 | -3 | 0.847 |
PKR |
0.799 | 0.026 | 1 | 0.840 |
BCKDK |
0.799 | -0.073 | -1 | 0.798 |
MNK2 |
0.798 | 0.064 | -2 | 0.821 |
JNK2 |
0.798 | 0.108 | 1 | 0.714 |
GRK7 |
0.798 | 0.034 | 1 | 0.745 |
TGFBR1 |
0.798 | 0.050 | -2 | 0.847 |
DLK |
0.797 | -0.096 | 1 | 0.813 |
QIK |
0.797 | 0.061 | -3 | 0.833 |
MSK2 |
0.797 | 0.029 | -3 | 0.784 |
CHAK2 |
0.797 | -0.076 | -1 | 0.845 |
CDK5 |
0.796 | 0.076 | 1 | 0.780 |
PKACB |
0.796 | 0.057 | -2 | 0.719 |
CAMK1G |
0.796 | 0.106 | -3 | 0.800 |
P38B |
0.796 | 0.112 | 1 | 0.724 |
ANKRD3 |
0.796 | -0.085 | 1 | 0.840 |
AKT2 |
0.796 | 0.076 | -3 | 0.753 |
CLK2 |
0.796 | 0.088 | -3 | 0.807 |
ERK1 |
0.795 | 0.095 | 1 | 0.718 |
MARK3 |
0.795 | 0.078 | 4 | 0.823 |
MYLK4 |
0.795 | 0.046 | -2 | 0.800 |
DYRK1A |
0.795 | 0.107 | 1 | 0.811 |
PIM2 |
0.795 | 0.045 | -3 | 0.793 |
ACVR2A |
0.795 | 0.043 | -2 | 0.818 |
IRE1 |
0.794 | -0.041 | 1 | 0.795 |
PRKX |
0.794 | 0.076 | -3 | 0.736 |
PKCB |
0.794 | 0.002 | 2 | 0.657 |
MARK2 |
0.794 | 0.075 | 4 | 0.787 |
PAK6 |
0.794 | 0.061 | -2 | 0.730 |
GRK4 |
0.794 | -0.084 | -2 | 0.851 |
CDK13 |
0.794 | 0.066 | 1 | 0.738 |
BRSK1 |
0.794 | 0.032 | -3 | 0.823 |
WNK3 |
0.794 | -0.152 | 1 | 0.797 |
CDK17 |
0.794 | 0.091 | 1 | 0.652 |
MSK1 |
0.794 | 0.048 | -3 | 0.788 |
NEK9 |
0.793 | -0.110 | 2 | 0.757 |
ALK2 |
0.793 | 0.045 | -2 | 0.849 |
PAK1 |
0.793 | -0.024 | -2 | 0.814 |
AURB |
0.793 | 0.038 | -2 | 0.694 |
PHKG1 |
0.793 | 0.029 | -3 | 0.841 |
RIPK1 |
0.793 | -0.087 | 1 | 0.799 |
JNK3 |
0.792 | 0.073 | 1 | 0.741 |
PLK1 |
0.792 | -0.050 | -2 | 0.846 |
MLK3 |
0.792 | -0.047 | 2 | 0.667 |
MASTL |
0.792 | -0.183 | -2 | 0.830 |
BMPR1A |
0.792 | 0.081 | 1 | 0.756 |
NIM1 |
0.792 | -0.057 | 3 | 0.771 |
MLK2 |
0.792 | -0.112 | 2 | 0.740 |
CDK16 |
0.792 | 0.113 | 1 | 0.667 |
PKCA |
0.792 | -0.012 | 2 | 0.647 |
CAMK1D |
0.791 | 0.147 | -3 | 0.742 |
HIPK3 |
0.791 | 0.112 | 1 | 0.780 |
PKCG |
0.791 | -0.029 | 2 | 0.648 |
P38G |
0.791 | 0.086 | 1 | 0.645 |
ACVR2B |
0.791 | 0.013 | -2 | 0.832 |
ULK1 |
0.791 | -0.162 | -3 | 0.767 |
CDK2 |
0.790 | 0.042 | 1 | 0.783 |
PKG2 |
0.790 | 0.037 | -2 | 0.723 |
SGK3 |
0.790 | 0.034 | -3 | 0.802 |
CDK14 |
0.789 | 0.104 | 1 | 0.740 |
PRP4 |
0.789 | 0.065 | -3 | 0.779 |
MNK1 |
0.789 | 0.026 | -2 | 0.833 |
ERK2 |
0.789 | 0.067 | 1 | 0.752 |
SSTK |
0.789 | 0.091 | 4 | 0.832 |
TTBK2 |
0.789 | -0.133 | 2 | 0.623 |
MEK1 |
0.789 | -0.105 | 2 | 0.737 |
TLK2 |
0.789 | -0.033 | 1 | 0.787 |
PKCH |
0.788 | -0.016 | 2 | 0.630 |
MARK1 |
0.788 | 0.056 | 4 | 0.834 |
MAPKAPK5 |
0.788 | 0.036 | -3 | 0.753 |
PAK3 |
0.788 | -0.050 | -2 | 0.810 |
CDK12 |
0.788 | 0.071 | 1 | 0.714 |
BRSK2 |
0.788 | 0.008 | -3 | 0.832 |
AURA |
0.787 | 0.026 | -2 | 0.662 |
PASK |
0.787 | 0.039 | -3 | 0.856 |
DYRK1B |
0.787 | 0.085 | 1 | 0.736 |
CDK9 |
0.787 | 0.057 | 1 | 0.744 |
DCAMKL1 |
0.787 | 0.042 | -3 | 0.826 |
CDK3 |
0.787 | 0.084 | 1 | 0.670 |
DYRK4 |
0.787 | 0.086 | 1 | 0.715 |
PKCZ |
0.787 | -0.031 | 2 | 0.686 |
DNAPK |
0.787 | -0.009 | 1 | 0.703 |
VRK2 |
0.786 | -0.136 | 1 | 0.867 |
CAMK1A |
0.786 | 0.184 | -3 | 0.724 |
P38D |
0.786 | 0.103 | 1 | 0.669 |
SMG1 |
0.785 | -0.045 | 1 | 0.781 |
PLK3 |
0.785 | -0.050 | 2 | 0.662 |
MLK4 |
0.785 | -0.092 | 2 | 0.644 |
GRK2 |
0.785 | -0.023 | -2 | 0.762 |
YSK4 |
0.785 | -0.116 | 1 | 0.751 |
IRE2 |
0.784 | -0.085 | 2 | 0.638 |
SMMLCK |
0.784 | 0.030 | -3 | 0.839 |
DCAMKL2 |
0.784 | 0.046 | -3 | 0.841 |
NEK2 |
0.784 | -0.083 | 2 | 0.727 |
CDK10 |
0.783 | 0.086 | 1 | 0.730 |
PKACA |
0.783 | 0.056 | -2 | 0.667 |
CHK2 |
0.783 | 0.140 | -3 | 0.711 |
DYRK3 |
0.783 | 0.079 | 1 | 0.788 |
PAK2 |
0.782 | -0.053 | -2 | 0.799 |
P70S6K |
0.782 | 0.024 | -3 | 0.752 |
PERK |
0.781 | -0.049 | -2 | 0.843 |
TLK1 |
0.781 | -0.041 | -2 | 0.860 |
SBK |
0.781 | 0.130 | -3 | 0.655 |
PINK1 |
0.781 | -0.078 | 1 | 0.870 |
BRAF |
0.780 | -0.083 | -4 | 0.824 |
HRI |
0.780 | -0.068 | -2 | 0.865 |
GAK |
0.780 | 0.036 | 1 | 0.844 |
AKT1 |
0.780 | 0.051 | -3 | 0.764 |
MST3 |
0.779 | -0.027 | 2 | 0.764 |
WNK4 |
0.779 | -0.028 | -2 | 0.866 |
PHKG2 |
0.779 | 0.016 | -3 | 0.830 |
CK2A2 |
0.778 | 0.067 | 1 | 0.686 |
MPSK1 |
0.778 | 0.029 | 1 | 0.811 |
MAK |
0.778 | 0.124 | -2 | 0.777 |
DRAK1 |
0.778 | -0.073 | 1 | 0.746 |
GSK3A |
0.778 | 0.014 | 4 | 0.422 |
MEKK3 |
0.778 | -0.128 | 1 | 0.784 |
MEKK2 |
0.777 | -0.099 | 2 | 0.714 |
MEK5 |
0.777 | -0.155 | 2 | 0.730 |
CHAK1 |
0.777 | -0.140 | 2 | 0.673 |
CK1E |
0.777 | -0.021 | -3 | 0.548 |
PKCT |
0.775 | -0.014 | 2 | 0.644 |
NEK5 |
0.775 | -0.097 | 1 | 0.817 |
TAO3 |
0.775 | -0.071 | 1 | 0.783 |
SNRK |
0.775 | -0.120 | 2 | 0.578 |
PKCE |
0.774 | 0.028 | 2 | 0.634 |
GRK3 |
0.774 | -0.008 | -2 | 0.720 |
DAPK3 |
0.774 | 0.031 | -3 | 0.834 |
PKCI |
0.774 | 0.006 | 2 | 0.656 |
PLK4 |
0.774 | -0.111 | 2 | 0.541 |
PKN1 |
0.773 | 0.074 | -3 | 0.772 |
ZAK |
0.773 | -0.126 | 1 | 0.765 |
GSK3B |
0.773 | -0.014 | 4 | 0.411 |
JNK1 |
0.772 | 0.058 | 1 | 0.696 |
MEKK1 |
0.772 | -0.169 | 1 | 0.799 |
IRAK4 |
0.772 | -0.098 | 1 | 0.795 |
CK1D |
0.771 | -0.008 | -3 | 0.496 |
SGK1 |
0.771 | 0.053 | -3 | 0.682 |
AKT3 |
0.770 | 0.052 | -3 | 0.700 |
ERK7 |
0.770 | -0.006 | 2 | 0.479 |
MOK |
0.770 | 0.097 | 1 | 0.792 |
PAK5 |
0.769 | 0.003 | -2 | 0.669 |
CK1A2 |
0.768 | -0.013 | -3 | 0.502 |
DAPK1 |
0.768 | 0.026 | -3 | 0.820 |
MRCKA |
0.768 | 0.033 | -3 | 0.791 |
PDK1 |
0.767 | -0.073 | 1 | 0.786 |
EEF2K |
0.767 | -0.032 | 3 | 0.805 |
MRCKB |
0.767 | 0.036 | -3 | 0.783 |
NEK8 |
0.767 | -0.128 | 2 | 0.718 |
TAO2 |
0.767 | -0.093 | 2 | 0.752 |
CDK6 |
0.767 | 0.052 | 1 | 0.722 |
CK2A1 |
0.766 | 0.045 | 1 | 0.662 |
GCK |
0.766 | -0.066 | 1 | 0.790 |
CK1G1 |
0.766 | -0.045 | -3 | 0.543 |
PLK2 |
0.765 | -0.018 | -3 | 0.772 |
LKB1 |
0.765 | -0.099 | -3 | 0.795 |
NEK11 |
0.765 | -0.150 | 1 | 0.783 |
DMPK1 |
0.764 | 0.065 | -3 | 0.812 |
TTBK1 |
0.764 | -0.117 | 2 | 0.538 |
MST2 |
0.764 | -0.080 | 1 | 0.789 |
TNIK |
0.764 | -0.044 | 3 | 0.818 |
CDK4 |
0.763 | 0.055 | 1 | 0.703 |
ROCK2 |
0.763 | 0.017 | -3 | 0.817 |
TAK1 |
0.763 | -0.080 | 1 | 0.817 |
PAK4 |
0.762 | -0.005 | -2 | 0.675 |
IRAK1 |
0.762 | -0.160 | -1 | 0.755 |
CRIK |
0.762 | 0.073 | -3 | 0.760 |
CAMKK1 |
0.762 | -0.170 | -2 | 0.767 |
LRRK2 |
0.762 | -0.093 | 2 | 0.747 |
HGK |
0.762 | -0.064 | 3 | 0.817 |
MINK |
0.761 | -0.068 | 1 | 0.782 |
NEK4 |
0.761 | -0.111 | 1 | 0.782 |
MEKK6 |
0.761 | -0.085 | 1 | 0.775 |
CAMKK2 |
0.761 | -0.140 | -2 | 0.760 |
HPK1 |
0.759 | -0.065 | 1 | 0.775 |
MAP3K15 |
0.759 | -0.111 | 1 | 0.747 |
LOK |
0.758 | -0.065 | -2 | 0.793 |
NEK1 |
0.758 | -0.062 | 1 | 0.786 |
KHS2 |
0.757 | -0.031 | 1 | 0.785 |
KHS1 |
0.756 | -0.049 | 1 | 0.769 |
PBK |
0.756 | -0.008 | 1 | 0.768 |
MST1 |
0.755 | -0.100 | 1 | 0.773 |
SLK |
0.755 | -0.086 | -2 | 0.743 |
BIKE |
0.753 | 0.056 | 1 | 0.732 |
PKG1 |
0.753 | 0.022 | -2 | 0.639 |
VRK1 |
0.752 | -0.183 | 2 | 0.720 |
HASPIN |
0.751 | 0.005 | -1 | 0.713 |
YSK1 |
0.751 | -0.077 | 2 | 0.742 |
TTK |
0.750 | -0.045 | -2 | 0.849 |
ROCK1 |
0.749 | 0.004 | -3 | 0.793 |
STK33 |
0.747 | -0.149 | 2 | 0.529 |
OSR1 |
0.746 | -0.083 | 2 | 0.729 |
MEK2 |
0.745 | -0.195 | 2 | 0.721 |
AAK1 |
0.744 | 0.098 | 1 | 0.640 |
PDHK3_TYR |
0.744 | 0.077 | 4 | 0.884 |
RIPK2 |
0.744 | -0.164 | 1 | 0.726 |
NEK3 |
0.743 | -0.085 | 1 | 0.745 |
MYO3B |
0.741 | -0.055 | 2 | 0.745 |
YANK3 |
0.740 | -0.054 | 2 | 0.353 |
MYO3A |
0.738 | -0.081 | 1 | 0.778 |
TESK1_TYR |
0.737 | -0.037 | 3 | 0.873 |
PDHK4_TYR |
0.736 | -0.025 | 2 | 0.775 |
ALPHAK3 |
0.736 | -0.087 | -1 | 0.778 |
ASK1 |
0.736 | -0.143 | 1 | 0.734 |
MAP2K4_TYR |
0.734 | -0.048 | -1 | 0.865 |
BMPR2_TYR |
0.734 | -0.014 | -1 | 0.868 |
PKMYT1_TYR |
0.733 | -0.034 | 3 | 0.834 |
MAP2K6_TYR |
0.733 | -0.065 | -1 | 0.868 |
TAO1 |
0.733 | -0.101 | 1 | 0.710 |
LIMK2_TYR |
0.731 | 0.010 | -3 | 0.864 |
MAP2K7_TYR |
0.731 | -0.138 | 2 | 0.756 |
CK1A |
0.731 | -0.043 | -3 | 0.411 |
PDHK1_TYR |
0.731 | -0.049 | -1 | 0.879 |
PINK1_TYR |
0.728 | -0.140 | 1 | 0.825 |
STLK3 |
0.724 | -0.152 | 1 | 0.731 |
EPHA6 |
0.722 | -0.060 | -1 | 0.862 |
LIMK1_TYR |
0.722 | -0.113 | 2 | 0.749 |
RET |
0.721 | -0.116 | 1 | 0.781 |
TYK2 |
0.720 | -0.084 | 1 | 0.778 |
MST1R |
0.720 | -0.078 | 3 | 0.786 |
EPHB4 |
0.718 | -0.081 | -1 | 0.839 |
JAK2 |
0.716 | -0.089 | 1 | 0.778 |
FGR |
0.716 | -0.058 | 1 | 0.826 |
DDR1 |
0.716 | -0.151 | 4 | 0.805 |
CK1G3 |
0.715 | -0.051 | -3 | 0.366 |
ROS1 |
0.715 | -0.119 | 3 | 0.733 |
TYRO3 |
0.715 | -0.140 | 3 | 0.772 |
FER |
0.715 | -0.093 | 1 | 0.833 |
TNNI3K_TYR |
0.714 | -0.005 | 1 | 0.817 |
EPHA4 |
0.714 | -0.052 | 2 | 0.662 |
TXK |
0.713 | -0.032 | 1 | 0.805 |
CSF1R |
0.713 | -0.127 | 3 | 0.762 |
YES1 |
0.711 | -0.089 | -1 | 0.831 |
ABL2 |
0.710 | -0.078 | -1 | 0.793 |
JAK3 |
0.710 | -0.122 | 1 | 0.756 |
INSRR |
0.710 | -0.112 | 3 | 0.736 |
HCK |
0.710 | -0.050 | -1 | 0.818 |
LCK |
0.709 | -0.023 | -1 | 0.827 |
EPHB1 |
0.709 | -0.071 | 1 | 0.808 |
SRMS |
0.709 | -0.091 | 1 | 0.812 |
NEK10_TYR |
0.707 | -0.076 | 1 | 0.658 |
FGFR2 |
0.707 | -0.141 | 3 | 0.795 |
ITK |
0.707 | -0.095 | -1 | 0.789 |
EPHB2 |
0.707 | -0.071 | -1 | 0.823 |
KIT |
0.707 | -0.125 | 3 | 0.776 |
EPHB3 |
0.707 | -0.087 | -1 | 0.819 |
KDR |
0.707 | -0.117 | 3 | 0.739 |
ABL1 |
0.707 | -0.077 | -1 | 0.787 |
PDGFRB |
0.706 | -0.152 | 3 | 0.780 |
TNK2 |
0.706 | -0.112 | 3 | 0.731 |
BLK |
0.705 | -0.038 | -1 | 0.821 |
WEE1_TYR |
0.705 | -0.060 | -1 | 0.760 |
YANK2 |
0.705 | -0.081 | 2 | 0.360 |
FLT3 |
0.705 | -0.126 | 3 | 0.763 |
TNK1 |
0.704 | -0.099 | 3 | 0.748 |
JAK1 |
0.704 | -0.059 | 1 | 0.718 |
FGFR1 |
0.704 | -0.125 | 3 | 0.760 |
FYN |
0.704 | -0.018 | -1 | 0.812 |
EPHA3 |
0.702 | -0.084 | 2 | 0.639 |
MET |
0.702 | -0.117 | 3 | 0.766 |
BMX |
0.702 | -0.058 | -1 | 0.719 |
MERTK |
0.701 | -0.105 | 3 | 0.765 |
TEK |
0.701 | -0.151 | 3 | 0.719 |
TEC |
0.701 | -0.089 | -1 | 0.727 |
AXL |
0.700 | -0.138 | 3 | 0.764 |
PTK6 |
0.700 | -0.125 | -1 | 0.726 |
EPHA7 |
0.700 | -0.082 | 2 | 0.658 |
PDGFRA |
0.700 | -0.150 | 3 | 0.772 |
LTK |
0.700 | -0.105 | 3 | 0.727 |
ALK |
0.699 | -0.116 | 3 | 0.701 |
FLT1 |
0.698 | -0.128 | -1 | 0.829 |
PTK2 |
0.697 | -0.001 | -1 | 0.801 |
PTK2B |
0.697 | -0.054 | -1 | 0.780 |
LYN |
0.696 | -0.071 | 3 | 0.688 |
ERBB2 |
0.696 | -0.124 | 1 | 0.726 |
FGFR3 |
0.696 | -0.152 | 3 | 0.772 |
BTK |
0.695 | -0.167 | -1 | 0.745 |
NTRK1 |
0.695 | -0.167 | -1 | 0.817 |
EPHA5 |
0.695 | -0.079 | 2 | 0.642 |
EPHA1 |
0.694 | -0.105 | 3 | 0.744 |
FRK |
0.694 | -0.090 | -1 | 0.815 |
DDR2 |
0.693 | -0.093 | 3 | 0.726 |
FLT4 |
0.693 | -0.156 | 3 | 0.737 |
INSR |
0.693 | -0.133 | 3 | 0.701 |
NTRK2 |
0.693 | -0.160 | 3 | 0.743 |
CK1G2 |
0.692 | -0.064 | -3 | 0.459 |
SRC |
0.691 | -0.070 | -1 | 0.801 |
EGFR |
0.691 | -0.072 | 1 | 0.633 |
SYK |
0.691 | -0.020 | -1 | 0.781 |
EPHA8 |
0.691 | -0.086 | -1 | 0.796 |
CSK |
0.690 | -0.106 | 2 | 0.666 |
MATK |
0.690 | -0.115 | -1 | 0.730 |
NTRK3 |
0.689 | -0.122 | -1 | 0.772 |
FGFR4 |
0.685 | -0.106 | -1 | 0.773 |
EPHA2 |
0.681 | -0.083 | -1 | 0.771 |
IGF1R |
0.679 | -0.123 | 3 | 0.655 |
ERBB4 |
0.676 | -0.077 | 1 | 0.655 |
MUSK |
0.674 | -0.118 | 1 | 0.615 |
FES |
0.668 | -0.103 | -1 | 0.707 |
ZAP70 |
0.663 | -0.074 | -1 | 0.712 |