Motif 973 (n=236)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A075B6Q4 | None | S68 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000256|ARBA:ARBA00043887}. |
| A6NDU8 | RIMOC1 | S238 | ochoa | RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51) | Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A. Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy. {ECO:0000269|PubMed:34432599}. |
| A8TX70 | COL6A5 | S859 | ochoa | Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| B2RTY4 | MYO9A | S48 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O14745 | NHERF1 | S217 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O14936 | CASK | S313 | ochoa | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O15360 | FANCA | S695 | ochoa | Fanconi anemia group A protein (Protein FACA) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
| O60701 | UGDH | S275 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O60941 | DTNB | S594 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75140 | DEPDC5 | S524 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75369 | FLNB | S1529 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75390 | CS | S97 | ochoa | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) | Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}. |
| O75794 | CDC123 | S314 | ochoa | Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32) | ATP-dependent protein-folding chaperone for the eIF2 complex (PubMed:35031321, PubMed:37507029). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity). {ECO:0000250|UniProtKB:Q05791, ECO:0000269|PubMed:35031321, ECO:0000269|PubMed:37507029}. |
| O94988 | FAM13A | S555 | ochoa | Protein FAM13A | None |
| O95239 | KIF4A | S508 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95644 | NFATC1 | S335 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O95772 | STARD3NL | S21 | ochoa | STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog) | Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}. |
| P04626 | ERBB2 | S1002 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P04899 | GNAI2 | S44 | psp | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05023 | ATP1A1 | S452 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05549 | TFAP2A | S222 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P05783 | KRT18 | S401 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P07195 | LDHB | S85 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P08133 | ANXA6 | S494 | ochoa | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P08151 | GLI1 | S204 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P08238 | HSP90AB1 | S445 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P0C0S8 | H2AC11 | T102 | ochoa | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P11766 | ADH5 | S247 | ochoa | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P28474, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}. |
| P13569 | CFTR | S795 | psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| P14314 | PRKCSH | S230 | ochoa | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| P16070 | CD44 | S672 | psp | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P17480 | UBTF | S238 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P18206 | VCL | S383 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18206 | VCL | S755 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18583 | SON | S354 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P20671 | H2AC7 | T102 | ochoa | Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P23443 | RPS6KB1 | S243 | ochoa | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P25705 | ATP5F1A | S462 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P31946 | YWHAB | S136 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P33981 | TTK | S317 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P34931 | HSPA1L | S546 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35573 | AGL | S894 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P40818 | USP8 | S153 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P46013 | MKI67 | S411 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46060 | RANGAP1 | S506 | ochoa|psp | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P48736 | PIK3CG | S582 | psp | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K) | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation, activation, and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway downstream of RASGRP4-mediated Ras-activation, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:Q9JHG7, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12163475, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:15294162, ECO:0000269|PubMed:16094730, ECO:0000269|PubMed:16123124, ECO:0000269|PubMed:21393242, ECO:0000269|PubMed:31554793, ECO:0000269|PubMed:33054089, ECO:0000269|PubMed:7624799}. |
| P49327 | FASN | S265 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P50991 | CCT4 | S202 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51587 | BRCA2 | S1099 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P51587 | BRCA2 | S1982 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P51948 | MNAT1 | S234 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P54132 | BLM | S601 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54578 | USP14 | S232 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P54868 | HMGCS2 | S324 | ochoa | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}. |
| P55196 | AFDN | S589 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55211 | CASP9 | S99 | psp | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}. |
| P56856 | CLDN18 | S228 | ochoa | Claudin-18 | Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity). {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection. {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A2]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. {ECO:0000250|UniProtKB:P56857}. |
| P61962 | DCAF7 | S38 | psp | DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog) | Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250, ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}. |
| P78316 | NOP14 | S239 | ochoa | Nucleolar protein 14 (Nucleolar complex protein 14) | Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}. |
| P78524 | DENND2B | S673 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78527 | PRKDC | S3205 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78563 | ADARB1 | S255 | ochoa | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. |
| P84022 | SMAD3 | S264 | psp | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| Q00987 | MDM2 | S121 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q02790 | FKBP4 | S350 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q03188 | CENPC | S684 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q06418 | TYRO3 | S466 | ochoa | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}. |
| Q06710 | PAX8 | S217 | ochoa | Paired box protein Pax-8 | Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. |
| Q07157 | TJP1 | S1102 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07869 | PPARA | S179 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q13418 | ILK | S186 | ochoa | Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) | Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:16517730, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:18283114, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:30367047, ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:9736715}. |
| Q13480 | GAB1 | S401 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13485 | SMAD4 | S155 | ochoa | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) | In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:9389648}. |
| Q14527 | HLTF | S381 | ochoa | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}. |
| Q14966 | ZNF638 | S671 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15327 | ANKRD1 | S213 | ochoa | Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein) | May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}. |
| Q15369 | ELOC | S39 | ochoa | Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1) | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P83940, ECO:0000269|PubMed:7821821}.; FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694, PubMed:21199876, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:30166453, PubMed:33268465, PubMed:38326650, PubMed:35512830). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:36805027, PubMed:38177675). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (PubMed:33268465). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). {ECO:0000250|UniProtKB:P83940, ECO:0000269|PubMed:10205047, ECO:0000269|PubMed:12004076, ECO:0000269|PubMed:12050673, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:21199876, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0000269|PubMed:38326650}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:18562529, PubMed:20532212, PubMed:22190037, PubMed:24225024, PubMed:24402281, PubMed:36754086). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699). {ECO:0000269|PubMed:18562529, ECO:0000269|PubMed:20532212, ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:24225024, ECO:0000269|PubMed:24402281, ECO:0000269|PubMed:36754086, ECO:0000269|PubMed:37640699}. |
| Q15722 | LTB4R | S313 | ochoa|psp | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Q16236 | NFE2L2 | S40 | psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
| Q16763 | UBE2S | S73 | ochoa | Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}. |
| Q16777 | H2AC20 | T102 | ochoa | Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q16825 | PTPN21 | S602 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q2PPJ7 | RALGAPA2 | S717 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q3MJ13 | WDR72 | S976 | ochoa | WD repeat-containing protein 72 | Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4, ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}. |
| Q49A88 | CCDC14 | S751 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q4G0J3 | LARP7 | S247 | ochoa | La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}. |
| Q562E7 | WDR81 | S1136 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q562F6 | SGO2 | S743 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5H943 | CT83 | S73 | ochoa | Kita-kyushu lung cancer antigen 1 (KK-LC-1) (Cancer/testis antigen 83) | None |
| Q5QJE6 | DNTTIP2 | S434 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5TB30 | DEPDC1 | S338 | ochoa | DEP domain-containing protein 1A | May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}. |
| Q5VWN6 | TASOR2 | S867 | ochoa | Protein TASOR 2 | None |
| Q5VYS8 | TUT7 | S85 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q68DQ2 | CRYBG3 | S144 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q68EM7 | ARHGAP17 | S162 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6FI13 | H2AC18 | T102 | ochoa | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6IQ23 | PLEKHA7 | S448 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6IQ55 | TTBK2 | S852 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6NT76 | HMBOX1 | S133 | ochoa | Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23685356, PubMed:23813958). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). {ECO:0000250|UniProtKB:Q8BJA3, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}. |
| Q6P4Q7 | CNNM4 | S728 | ochoa | Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}. |
| Q6UB99 | ANKRD11 | S1307 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6VUC0 | TFAP2E | S229 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
| Q6XZF7 | DNMBP | S316 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6XZF7 | DNMBP | S540 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZV89 | SH2D5 | S197 | ochoa | SH2 domain-containing protein 5 | May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. {ECO:0000250|UniProtKB:Q8JZW5}. |
| Q70CQ2 | USP34 | S486 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q7KZI7 | MARK2 | S29 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z5J4 | RAI1 | S846 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6R9 | TFAP2D | S222 | ochoa | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}. |
| Q86TI0 | TBC1D1 | S503 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86U86 | PBRM1 | S1410 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UP2 | KTN1 | S1084 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86US8 | SMG6 | S85 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86V48 | LUZP1 | S248 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86V48 | LUZP1 | S839 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86W92 | PPFIBP1 | S460 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q86XP3 | DDX42 | S104 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8IW35 | CEP97 | S371 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IWU2 | LMTK2 | S438 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IY22 | CMIP | S660 | ochoa | C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}. |
| Q8IZH2 | XRN1 | S1045 | ochoa | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. |
| Q8N1I0 | DOCK4 | S1755 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N4C6 | NIN | S1837 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8NB90 | AFG2A | S274 | ochoa | ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q8ND24 | RNF214 | S40 | ochoa | RING finger protein 214 | None |
| Q8NEV8 | EXPH5 | S1501 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEZ3 | WDR19 | S893 | ochoa | WD repeat-containing protein 19 (Intraflagellar transport 144 homolog) | As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed:20889716). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed:20889716). Associates with the BBSome complex to mediate ciliary transport (By similarity). {ECO:0000250|UniProtKB:Q3UGF1, ECO:0000269|PubMed:20889716}. |
| Q8NFU3 | TSTD1 | S94 | ochoa | Thiosulfate:glutathione sulfurtransferase (TST) (EC 2.8.1.3) | Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). GSS(-) spontaneously reacts with glutathione to form glutathione disulfide (Probable). {ECO:0000269|PubMed:24981631, ECO:0000305}. |
| Q8TCU6 | PREX1 | S436 | psp | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TDG4 | HELQ | S1054 | ochoa | Helicase POLQ-like (EC 5.6.2.4) (Mus308-like helicase) (POLQ-like helicase) | Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:11751861, PubMed:19995904, PubMed:21398521, PubMed:24005041, PubMed:24005565, PubMed:34316696, PubMed:34937945). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (PubMed:34937945). Possesses both DNA unwinding and annealing activities (PubMed:34937945). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (PubMed:34937945). Efficiently unwinds substrates containing 3' overhangs or a D-loop (PubMed:21398521, PubMed:34937945). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (PubMed:34937945). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (PubMed:34316696, PubMed:34937945). {ECO:0000269|PubMed:11751861, ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:21398521, ECO:0000269|PubMed:24005041, ECO:0000269|PubMed:24005565, ECO:0000269|PubMed:34316696, ECO:0000269|PubMed:34937945}. |
| Q8TDM6 | DLG5 | S900 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEW0 | PARD3 | S225 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WWQ0 | PHIP | S1734 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WXG6 | MADD | S762 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q92481 | TFAP2B | S241 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
| Q92621 | NUP205 | S942 | ochoa | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
| Q92754 | TFAP2C | S235 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
| Q92888 | ARHGEF1 | S631 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q93009 | USP7 | S967 | ochoa | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}. |
| Q93077 | H2AC6 | T102 | ochoa | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96A65 | EXOC4 | S32 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
| Q96DR7 | ARHGEF26 | S422 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96DR7 | ARHGEF26 | S739 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96GA3 | LTV1 | S244 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96GM8 | TOE1 | S358 | ochoa | Target of EGR1 protein 1 | Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}. |
| Q96KK5 | H2AC12 | T102 | ochoa | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96M96 | FGD4 | S388 | ochoa | FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}. |
| Q96QE3 | ATAD5 | S261 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96QT4 | TRPM7 | S1598 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RL1 | UIMC1 | S29 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99878 | H2AC14 | T102 | ochoa | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99988 | GDF15 | S72 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BPZ7 | MAPKAP1 | S200 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BS91 | SLC35A5 | S401 | ochoa | UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) | Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi. {ECO:0000269|PubMed:2322548, ECO:0000269|PubMed:30641943}. |
| Q9BSC4 | NOL10 | S514 | ochoa | Nucleolar protein 10 | None |
| Q9BTT0 | ANP32E | S104 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) | Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}. |
| Q9BY89 | KIAA1671 | S726 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0C9 | UBE2O | S73 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0F1 | CEP44 | S342 | ochoa | Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3) | Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111). {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}. |
| Q9H000 | MKRN2 | S366 | ochoa | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). {ECO:0000250|UniProtKB:Q9ERV1}. |
| Q9H1D0 | TRPV6 | S184 | psp | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}. |
| Q9H1I8 | ASCC2 | S706 | ochoa | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q9H4Z2 | ZNF335 | S686 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H6R7 | WDCP | S416 | ochoa | WD repeat and coiled-coil-containing protein | None |
| Q9H814 | PHAX | S146 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9H8K7 | PAAT | S424 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9HBI1 | PARVB | S254 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
| Q9NQA5 | TRPV5 | S144 | psp | Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:11549322, ECO:0000269|PubMed:18768590}. |
| Q9NQC7 | CYLD | S362 | psp | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NQC7 | CYLD | S552 | ochoa | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NR46 | SH3GLB2 | S207 | ochoa | Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) | None |
| Q9NRY4 | ARHGAP35 | S591 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NS56 | TOPORS | S718 | psp | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NXG2 | THUMPD1 | S295 | ochoa | THUMP domain-containing protein 1 | Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C) (PubMed:25653167, PubMed:35196516). {ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:35196516}. |
| Q9NXL9 | MCM9 | S663 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NYF8 | BCLAF1 | S564 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYL2 | MAP3K20 | S268 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NYL2 | MAP3K20 | S362 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P1W3 | TMEM63C | S80 | ochoa | Osmosensitive cation channel TMEM63C (Calcium permeable stress-gated cation channel 1) (Transmembrane protein 63C) (hTMEM63C) | Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:24503647, PubMed:35718349). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (PubMed:35718349). In particular may regulate mitochondrial motility and function in motor neuron axons (PubMed:35718349). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). {ECO:0000250|UniProtKB:D3ZNF5, ECO:0000269|PubMed:24503647, ECO:0000269|PubMed:35718349, ECO:0000269|PubMed:39716028}. |
| Q9P2K8 | EIF2AK4 | S572 | ochoa | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| Q9UBF9 | MYOT | S225 | ochoa | Myotilin (57 kDa cytoskeletal protein) (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein) | Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. {ECO:0000269|PubMed:12499399}. |
| Q9UBU7 | DBF4 | S571 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UKE5 | TNIK | S972 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKY1 | ZHX1 | S591 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9UMZ2 | SYNRG | S785 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UNS1 | TIMELESS | S126 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9UPN4 | CEP131 | S450 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y2B0 | CNPY2 | S74 | ochoa | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| Q9Y2F5 | ICE1 | S671 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2H5 | PLEKHA6 | S962 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y365 | STARD10 | S253 | ochoa | START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) | May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}. |
| Q9Y483 | MTF2 | S513 | ochoa | Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}. |
| Q9Y4F4 | TOGARAM1 | S484 | ochoa | TOG array regulator of axonemal microtubules protein 1 (Crescerin-1) (Protein FAM179B) | Involved in ciliogenesis (PubMed:32453716). It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (PubMed:32453716). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). {ECO:0000250|UniProtKB:Q17423, ECO:0000250|UniProtKB:Q6A070, ECO:0000269|PubMed:32453716}. |
| Q9Y6Y8 | SEC23IP | S894 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| P00491 | PNP | S163 | Sugiyama | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) | Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964). {ECO:0000269|PubMed:23438750, ECO:0000269|PubMed:9305964}. |
| O43423 | ANP32CP | S100 | Sugiyama | Putative uncharacterized protein ANP32CP (Acidic leucine-rich nuclear phosphoprotein 32 family member C) (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1) | None |
| O95626 | ANP32D | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member D (Phosphoprotein 32-related protein 2) (Tumorigenic protein pp32r2) | None |
| P39687 | ANP32A | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| P30086 | PEBP1 | S139 | Sugiyama | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| O95881 | TXNDC12 | S136 | Sugiyama | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}. |
| Q96GA3 | LTV1 | S34 | Sugiyama | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q99816 | TSG101 | S232 | Sugiyama | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q92688 | ANP32B | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| Q92688 | ANP32B | S134 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| P62241 | RPS8 | S115 | Sugiyama | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P47897 | QARS1 | S750 | Sugiyama | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) | Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}. |
| P23142 | FBLN1 | S247 | Sugiyama | Fibulin-1 (FIBL-1) | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. |
| Q12906 | ILF3 | S19 | Sugiyama | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q9Y281 | CFL2 | S70 | Sugiyama | Cofilin-2 (Cofilin, muscle isoform) | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}. |
| Q5QJE6 | DNTTIP2 | S703 | Sugiyama | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| P11441 | UBL4A | S60 | Sugiyama | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}. |
| Q00610 | CLTC | S1483 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| P10721 | KIT | S729 | Sugiyama | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| O60479 | DLX3 | S138 | SIGNOR|iPTMNet|EPSD | Homeobox protein DLX-3 | Transcriptional activator (By similarity). Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q64205}. |
| Q9UI26 | IPO11 | S214 | Sugiyama | Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11032817}. |
| Q01082 | SPTBN1 | S1966 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| P50990 | CCT8 | S243 | Sugiyama | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q00610 | CLTC | S902 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| O15355 | PPM1G | S349 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| Q8TB72 | PUM2 | S943 | Sugiyama | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| P61769 | B2M | S77 | Sugiyama | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}. |
| Q13237 | PRKG2 | S285 | Sugiyama | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
| Q13464 | ROCK1 | S417 | Sugiyama | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q14289 | PTK2B | S866 | Sugiyama | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q9GZL7 | WDR12 | S206 | Sugiyama | Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:17353269}. |
| Q15303 | ERBB4 | S1263 | Sugiyama | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q99962 | SH3GL2 | S75 | SIGNOR | Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}. |
| P06756 | ITGAV | S127 | Sugiyama | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). {ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
| P04843 | RPN1 | S276 | Sugiyama | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39567208}. |
| P36954 | POLR2I | S73 | Sugiyama | DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5) | Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2I/RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. {ECO:0000250|UniProtKB:P27999, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:9852112}. |
| Q9Y230 | RUVBL2 | S358 | Sugiyama | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| Q14444 | CAPRIN1 | S120 | Sugiyama | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
| Q15154 | PCM1 | S588 | Sugiyama | Pericentriolar material 1 protein (PCM-1) (hPCM-1) | Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:34782749}. |
| Q9UK32 | RPS6KA6 | S223 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q14524 | SCN5A | S1925 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q9Y572 | RIPK3 | S199 | GPS6|EPSD | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5689880 | Ub-specific processing proteases | 8.287743e-09 | 8.082 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 4.728588e-08 | 7.325 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 3.830722e-08 | 7.417 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.059963e-08 | 7.514 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.915411e-08 | 7.718 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 9.832087e-08 | 7.007 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.051737e-07 | 6.978 |
| R-HSA-5688426 | Deubiquitination | 3.516968e-07 | 6.454 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.369412e-06 | 5.863 |
| R-HSA-3371568 | Attenuation phase | 1.831099e-06 | 5.737 |
| R-HSA-1500931 | Cell-Cell communication | 1.681256e-06 | 5.774 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 2.370717e-06 | 5.625 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 2.875802e-06 | 5.541 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 3.488939e-06 | 5.457 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.823054e-06 | 5.418 |
| R-HSA-3371571 | HSF1-dependent transactivation | 9.485873e-06 | 5.023 |
| R-HSA-446728 | Cell junction organization | 1.749560e-05 | 4.757 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.525943e-05 | 4.598 |
| R-HSA-912446 | Meiotic recombination | 7.876586e-05 | 4.104 |
| R-HSA-421270 | Cell-cell junction organization | 7.616844e-05 | 4.118 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 8.734297e-05 | 4.059 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.074077e-04 | 3.969 |
| R-HSA-3371511 | HSF1 activation | 1.074077e-04 | 3.969 |
| R-HSA-5689603 | UCH proteinases | 1.115127e-04 | 3.953 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.177462e-04 | 3.929 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.219437e-04 | 3.914 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.731465e-04 | 3.762 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.781832e-04 | 3.556 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.793016e-04 | 3.554 |
| R-HSA-418990 | Adherens junctions interactions | 2.581800e-04 | 3.588 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 3.408060e-04 | 3.467 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.647091e-04 | 3.438 |
| R-HSA-5334118 | DNA methylation | 3.647091e-04 | 3.438 |
| R-HSA-774815 | Nucleosome assembly | 3.272938e-04 | 3.485 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.272938e-04 | 3.485 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.364889e-04 | 3.473 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.660314e-04 | 3.436 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.811373e-04 | 3.419 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.141653e-04 | 3.383 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.141653e-04 | 3.383 |
| R-HSA-1266738 | Developmental Biology | 4.466627e-04 | 3.350 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 4.953174e-04 | 3.305 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.570161e-04 | 3.340 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.920339e-04 | 3.308 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.910541e-04 | 3.309 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.155934e-04 | 3.288 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.155934e-04 | 3.288 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.280752e-04 | 3.277 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 5.887876e-04 | 3.230 |
| R-HSA-3371556 | Cellular response to heat stress | 5.755096e-04 | 3.240 |
| R-HSA-73886 | Chromosome Maintenance | 5.755096e-04 | 3.240 |
| R-HSA-157579 | Telomere Maintenance | 5.891658e-04 | 3.230 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 5.931475e-04 | 3.227 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.381584e-04 | 3.195 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.540751e-04 | 3.184 |
| R-HSA-3214847 | HATs acetylate histones | 6.629776e-04 | 3.179 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 7.411221e-04 | 3.130 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 7.411221e-04 | 3.130 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.495909e-04 | 3.125 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.875149e-04 | 3.104 |
| R-HSA-9834899 | Specification of the neural plate border | 8.121671e-04 | 3.090 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 8.558197e-04 | 3.068 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 9.315276e-04 | 3.031 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.012623e-03 | 2.995 |
| R-HSA-1474165 | Reproduction | 9.929890e-04 | 3.003 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.012623e-03 | 2.995 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.103756e-03 | 2.957 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.183754e-03 | 2.927 |
| R-HSA-1500620 | Meiosis | 1.173766e-03 | 2.930 |
| R-HSA-73927 | Depurination | 1.117695e-03 | 2.952 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.213476e-03 | 2.916 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 1.246071e-03 | 2.904 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 1.246071e-03 | 2.904 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 1.246071e-03 | 2.904 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.351791e-03 | 2.869 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.481528e-03 | 2.829 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.481528e-03 | 2.829 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.808367e-03 | 2.743 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.768185e-03 | 2.752 |
| R-HSA-73928 | Depyrimidination | 1.768185e-03 | 2.752 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.832143e-03 | 2.737 |
| R-HSA-9710421 | Defective pyroptosis | 1.925836e-03 | 2.715 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.082429e-03 | 2.681 |
| R-HSA-3295583 | TRP channels | 2.310246e-03 | 2.636 |
| R-HSA-9758941 | Gastrulation | 2.456407e-03 | 2.610 |
| R-HSA-73894 | DNA Repair | 2.389669e-03 | 2.622 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.345818e-03 | 2.630 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.460506e-03 | 2.609 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.178563e-03 | 2.498 |
| R-HSA-9610379 | HCMV Late Events | 3.334764e-03 | 2.477 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 3.384918e-03 | 2.470 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.458789e-03 | 2.461 |
| R-HSA-1640170 | Cell Cycle | 3.468361e-03 | 2.460 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.511359e-03 | 2.455 |
| R-HSA-162582 | Signal Transduction | 3.890753e-03 | 2.410 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.983013e-03 | 2.400 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.983013e-03 | 2.400 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.115872e-03 | 2.386 |
| R-HSA-1221632 | Meiotic synapsis | 4.115872e-03 | 2.386 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 4.346275e-03 | 2.362 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.686646e-03 | 2.329 |
| R-HSA-211000 | Gene Silencing by RNA | 4.565415e-03 | 2.341 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.404426e-03 | 2.356 |
| R-HSA-977225 | Amyloid fiber formation | 4.443884e-03 | 2.352 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 4.820307e-03 | 2.317 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 4.820307e-03 | 2.317 |
| R-HSA-8939211 | ESR-mediated signaling | 4.917003e-03 | 2.308 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 5.533295e-03 | 2.257 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.703602e-03 | 2.244 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 5.724919e-03 | 2.242 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 6.521973e-03 | 2.186 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.445237e-03 | 2.191 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.667845e-03 | 2.176 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.445237e-03 | 2.191 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.252033e-03 | 2.140 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.252033e-03 | 2.140 |
| R-HSA-373760 | L1CAM interactions | 7.262464e-03 | 2.139 |
| R-HSA-2559583 | Cellular Senescence | 7.506722e-03 | 2.125 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.680736e-03 | 2.115 |
| R-HSA-8848021 | Signaling by PTK6 | 7.680736e-03 | 2.115 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.169471e-03 | 2.088 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 8.213854e-03 | 2.085 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 8.381089e-03 | 2.077 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 8.381089e-03 | 2.077 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 8.835899e-03 | 2.054 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 9.193842e-03 | 2.037 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 8.381089e-03 | 2.077 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 9.196128e-03 | 2.036 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 8.381089e-03 | 2.077 |
| R-HSA-69306 | DNA Replication | 9.458812e-03 | 2.024 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.004519e-02 | 1.998 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.009082e-02 | 1.996 |
| R-HSA-5617833 | Cilium Assembly | 1.011144e-02 | 1.995 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.049034e-02 | 1.979 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.049034e-02 | 1.979 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.118533e-02 | 1.951 |
| R-HSA-597592 | Post-translational protein modification | 1.136606e-02 | 1.944 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.176181e-02 | 1.930 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.334575e-02 | 1.875 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.366190e-02 | 1.864 |
| R-HSA-8852135 | Protein ubiquitination | 1.426945e-02 | 1.846 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-9669921 | KIT mutants bind TKIs | 1.681098e-02 | 1.774 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 1.681098e-02 | 1.774 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.628360e-02 | 1.788 |
| R-HSA-437239 | Recycling pathway of L1 | 1.493425e-02 | 1.826 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.636992e-02 | 1.786 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.538002e-02 | 1.813 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.475056e-02 | 1.831 |
| R-HSA-9620244 | Long-term potentiation | 1.628360e-02 | 1.788 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.726538e-02 | 1.763 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.752612e-02 | 1.756 |
| R-HSA-2262752 | Cellular responses to stress | 1.878516e-02 | 1.726 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.985390e-02 | 1.702 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.026309e-02 | 1.693 |
| R-HSA-8953854 | Metabolism of RNA | 2.073077e-02 | 1.683 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.094093e-02 | 1.679 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 2.094093e-02 | 1.679 |
| R-HSA-195721 | Signaling by WNT | 2.110015e-02 | 1.676 |
| R-HSA-9824446 | Viral Infection Pathways | 2.122429e-02 | 1.673 |
| R-HSA-68886 | M Phase | 2.133613e-02 | 1.671 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.152479e-02 | 1.667 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 2.727313e-02 | 1.564 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.402058e-02 | 1.619 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.437555e-02 | 1.613 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.313966e-02 | 1.636 |
| R-HSA-73884 | Base Excision Repair | 2.781945e-02 | 1.556 |
| R-HSA-68875 | Mitotic Prophase | 2.789059e-02 | 1.555 |
| R-HSA-73887 | Death Receptor Signaling | 2.868668e-02 | 1.542 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.886648e-02 | 1.540 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.057788e-02 | 1.515 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 3.069193e-02 | 1.513 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 3.069193e-02 | 1.513 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 3.069193e-02 | 1.513 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.078716e-02 | 1.512 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.134359e-02 | 1.504 |
| R-HSA-9609690 | HCMV Early Events | 3.174650e-02 | 1.498 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.206038e-02 | 1.494 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 3.334037e-02 | 1.477 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 3.334037e-02 | 1.477 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 3.334037e-02 | 1.477 |
| R-HSA-422475 | Axon guidance | 3.341222e-02 | 1.476 |
| R-HSA-373755 | Semaphorin interactions | 3.374375e-02 | 1.472 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 3.427053e-02 | 1.465 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 3.800262e-02 | 1.420 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.671291e-02 | 1.331 |
| R-HSA-167169 | HIV Transcription Elongation | 4.671291e-02 | 1.331 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.671291e-02 | 1.331 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.432644e-02 | 1.353 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.476391e-02 | 1.349 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.974241e-02 | 1.401 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 4.188208e-02 | 1.378 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 4.188208e-02 | 1.378 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.754588e-02 | 1.425 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.671291e-02 | 1.331 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.671291e-02 | 1.331 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.188208e-02 | 1.378 |
| R-HSA-1502540 | Signaling by Activin | 4.188208e-02 | 1.378 |
| R-HSA-9609646 | HCMV Infection | 4.253604e-02 | 1.371 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.382399e-02 | 1.358 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.394136e-02 | 1.357 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.669105e-02 | 1.331 |
| R-HSA-4839726 | Chromatin organization | 4.172453e-02 | 1.380 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.476391e-02 | 1.349 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.855464e-02 | 1.414 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.657451e-02 | 1.332 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.847834e-02 | 1.314 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 4.959287e-02 | 1.305 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 4.959287e-02 | 1.305 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 4.959287e-02 | 1.305 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.030304e-02 | 1.298 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.030304e-02 | 1.298 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.041326e-02 | 1.297 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.557310e-02 | 1.183 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.557310e-02 | 1.183 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.557310e-02 | 1.183 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.557310e-02 | 1.183 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.557310e-02 | 1.183 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.557310e-02 | 1.183 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.557310e-02 | 1.183 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.557310e-02 | 1.183 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.557310e-02 | 1.183 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.557310e-02 | 1.183 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.557310e-02 | 1.183 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 5.875651e-02 | 1.231 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 6.328634e-02 | 1.199 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 6.793002e-02 | 1.168 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 6.793002e-02 | 1.168 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 6.793002e-02 | 1.168 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 6.793002e-02 | 1.168 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 6.793002e-02 | 1.168 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.512422e-02 | 1.186 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.512422e-02 | 1.186 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.216506e-02 | 1.283 |
| R-HSA-9823730 | Formation of definitive endoderm | 6.793002e-02 | 1.168 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.512422e-02 | 1.186 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.512422e-02 | 1.186 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 5.875651e-02 | 1.231 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.512422e-02 | 1.186 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.681729e-02 | 1.246 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.167192e-02 | 1.287 |
| R-HSA-9827857 | Specification of primordial germ cells | 5.434573e-02 | 1.265 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 6.328634e-02 | 1.199 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 6.557310e-02 | 1.183 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 6.557310e-02 | 1.183 |
| R-HSA-75102 | C6 deamination of adenosine | 6.557310e-02 | 1.183 |
| R-HSA-1181150 | Signaling by NODAL | 6.793002e-02 | 1.168 |
| R-HSA-162906 | HIV Infection | 6.161121e-02 | 1.210 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.512422e-02 | 1.186 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.687478e-02 | 1.245 |
| R-HSA-6807004 | Negative regulation of MET activity | 6.793002e-02 | 1.168 |
| R-HSA-392499 | Metabolism of proteins | 6.087682e-02 | 1.216 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.203412e-02 | 1.284 |
| R-HSA-373753 | Nephrin family interactions | 6.793002e-02 | 1.168 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.356616e-02 | 1.271 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.356616e-02 | 1.271 |
| R-HSA-9675108 | Nervous system development | 5.342091e-02 | 1.272 |
| R-HSA-2028269 | Signaling by Hippo | 5.434573e-02 | 1.265 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.330466e-02 | 1.199 |
| R-HSA-9679506 | SARS-CoV Infections | 6.817351e-02 | 1.166 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 7.268246e-02 | 1.139 |
| R-HSA-1989781 | PPARA activates gene expression | 7.623203e-02 | 1.118 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 7.753874e-02 | 1.110 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.951543e-02 | 1.100 |
| R-HSA-162587 | HIV Life Cycle | 7.951543e-02 | 1.100 |
| R-HSA-8865999 | MET activates PTPN11 | 8.128560e-02 | 1.090 |
| R-HSA-438064 | Post NMDA receptor activation events | 8.207242e-02 | 1.086 |
| R-HSA-166208 | mTORC1-mediated signalling | 8.249403e-02 | 1.084 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 8.314883e-02 | 1.080 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 8.314883e-02 | 1.080 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.556304e-02 | 1.068 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 8.634092e-02 | 1.064 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 8.754367e-02 | 1.058 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 8.754367e-02 | 1.058 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 8.754367e-02 | 1.058 |
| R-HSA-3000170 | Syndecan interactions | 8.754367e-02 | 1.058 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.758223e-02 | 1.058 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.938215e-02 | 1.049 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 9.169483e-02 | 1.038 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 9.169483e-02 | 1.038 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 9.169483e-02 | 1.038 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 9.268313e-02 | 1.033 |
| R-HSA-429947 | Deadenylation of mRNA | 9.268313e-02 | 1.033 |
| R-HSA-9735763 | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | 9.673485e-02 | 1.014 |
| R-HSA-9735786 | Nucleotide catabolism defects | 9.673485e-02 | 1.014 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 9.673485e-02 | 1.014 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 9.673485e-02 | 1.014 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 9.673485e-02 | 1.014 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 9.673485e-02 | 1.014 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 1.119252e-01 | 0.951 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 1.119252e-01 | 0.951 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 1.119252e-01 | 0.951 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.268611e-01 | 0.897 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.415466e-01 | 0.849 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.559861e-01 | 0.807 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.559861e-01 | 0.807 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 1.701835e-01 | 0.769 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.701835e-01 | 0.769 |
| R-HSA-444257 | RSK activation | 1.701835e-01 | 0.769 |
| R-HSA-196025 | Formation of annular gap junctions | 1.701835e-01 | 0.769 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.701835e-01 | 0.769 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.701835e-01 | 0.769 |
| R-HSA-8875656 | MET receptor recycling | 1.701835e-01 | 0.769 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.701835e-01 | 0.769 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.841430e-01 | 0.735 |
| R-HSA-190873 | Gap junction degradation | 1.841430e-01 | 0.735 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.841430e-01 | 0.735 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.978685e-01 | 0.704 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.246331e-01 | 0.649 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 9.790796e-02 | 1.009 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.376798e-01 | 0.624 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.085967e-01 | 0.964 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.085967e-01 | 0.964 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.140524e-01 | 0.943 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.140524e-01 | 0.943 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.140524e-01 | 0.943 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.140524e-01 | 0.943 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.195770e-01 | 0.922 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.195770e-01 | 0.922 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.631207e-01 | 0.580 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.755221e-01 | 0.560 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.755221e-01 | 0.560 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.539641e-01 | 0.813 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 9.622155e-02 | 1.017 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.030529e-01 | 0.987 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.718006e-01 | 0.765 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.021947e-01 | 0.694 |
| R-HSA-167161 | HIV Transcription Initiation | 2.021947e-01 | 0.694 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.021947e-01 | 0.694 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.398511e-01 | 0.854 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.145224e-01 | 0.669 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.269175e-01 | 0.644 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.269175e-01 | 0.644 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.331347e-01 | 0.632 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.331347e-01 | 0.632 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.393620e-01 | 0.621 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.678552e-01 | 0.775 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.705804e-01 | 0.568 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.768271e-01 | 0.558 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.768271e-01 | 0.558 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.146848e-01 | 0.668 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.146848e-01 | 0.668 |
| R-HSA-167172 | Transcription of the HIV genome | 1.398511e-01 | 0.854 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 2.505078e-01 | 0.601 |
| R-HSA-72086 | mRNA Capping | 1.195770e-01 | 0.922 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.021947e-01 | 0.694 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.365264e-01 | 0.865 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.978685e-01 | 0.704 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.246331e-01 | 0.649 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.308176e-01 | 0.883 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.718006e-01 | 0.765 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.021947e-01 | 0.694 |
| R-HSA-111458 | Formation of apoptosome | 1.978685e-01 | 0.704 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.283805e-01 | 0.892 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.234869e-01 | 0.651 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.539641e-01 | 0.813 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.455975e-01 | 0.610 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.637574e-01 | 0.786 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.103122e-01 | 0.677 |
| R-HSA-191650 | Regulation of gap junction activity | 9.673485e-02 | 1.014 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 2.246331e-01 | 0.649 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.085967e-01 | 0.964 |
| R-HSA-418457 | cGMP effects | 2.631207e-01 | 0.580 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.658160e-01 | 0.780 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.643323e-01 | 0.578 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.539641e-01 | 0.813 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.190766e-01 | 0.659 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.598695e-01 | 0.796 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.215504e-01 | 0.915 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.778204e-01 | 0.750 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.481030e-01 | 0.829 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.841430e-01 | 0.735 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.978685e-01 | 0.704 |
| R-HSA-420029 | Tight junction interactions | 9.790796e-02 | 1.009 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.422893e-01 | 0.847 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.675836e-01 | 0.776 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.984027e-01 | 0.702 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.130878e-01 | 0.947 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 9.673485e-02 | 1.014 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.268611e-01 | 0.897 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 1.308176e-01 | 0.883 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.899539e-01 | 0.721 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.930338e-01 | 0.714 |
| R-HSA-5693538 | Homology Directed Repair | 1.875118e-01 | 0.727 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.960622e-01 | 0.708 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.292562e-01 | 0.640 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.696570e-01 | 0.569 |
| R-HSA-391251 | Protein folding | 2.502859e-01 | 0.602 |
| R-HSA-69541 | Stabilization of p53 | 1.838724e-01 | 0.735 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.757159e-01 | 0.560 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 9.673485e-02 | 1.014 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 1.119252e-01 | 0.951 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.701835e-01 | 0.769 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.978685e-01 | 0.704 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.376798e-01 | 0.624 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.085967e-01 | 0.964 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.505078e-01 | 0.601 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.505078e-01 | 0.601 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.755221e-01 | 0.560 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.698682e-01 | 0.770 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.215504e-01 | 0.915 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 2.376798e-01 | 0.624 |
| R-HSA-170968 | Frs2-mediated activation | 2.505078e-01 | 0.601 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.559861e-01 | 0.807 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.768271e-01 | 0.558 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.671083e-01 | 0.777 |
| R-HSA-1566948 | Elastic fibre formation | 1.778204e-01 | 0.750 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.516523e-01 | 0.819 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.268611e-01 | 0.897 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.978685e-01 | 0.704 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.032139e-01 | 0.986 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 2.505078e-01 | 0.601 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.631207e-01 | 0.580 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.755221e-01 | 0.560 |
| R-HSA-9766229 | Degradation of CDH1 | 2.518389e-01 | 0.599 |
| R-HSA-73942 | DNA Damage Reversal | 2.755221e-01 | 0.560 |
| R-HSA-9764561 | Regulation of CDH1 Function | 9.961345e-02 | 1.002 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.556549e-01 | 0.808 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.696570e-01 | 0.569 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.518389e-01 | 0.599 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.518389e-01 | 0.599 |
| R-HSA-75893 | TNF signaling | 9.622155e-02 | 1.017 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 9.673485e-02 | 1.014 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 1.119252e-01 | 0.951 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.559861e-01 | 0.807 |
| R-HSA-75072 | mRNA Editing | 1.841430e-01 | 0.735 |
| R-HSA-170984 | ARMS-mediated activation | 1.841430e-01 | 0.735 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 2.246331e-01 | 0.649 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.085967e-01 | 0.964 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.631207e-01 | 0.580 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.755221e-01 | 0.560 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.755221e-01 | 0.560 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.899539e-01 | 0.721 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.083489e-01 | 0.681 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.637574e-01 | 0.786 |
| R-HSA-6806834 | Signaling by MET | 1.887718e-01 | 0.724 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.085967e-01 | 0.964 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.899539e-01 | 0.721 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.768271e-01 | 0.558 |
| R-HSA-1280218 | Adaptive Immune System | 9.752504e-02 | 1.011 |
| R-HSA-216083 | Integrin cell surface interactions | 1.803236e-01 | 0.744 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.065391e-01 | 0.972 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.778204e-01 | 0.750 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.593266e-01 | 0.586 |
| R-HSA-69481 | G2/M Checkpoints | 9.590550e-02 | 1.018 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.518389e-01 | 0.599 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.867924e-01 | 0.729 |
| R-HSA-199991 | Membrane Trafficking | 1.674496e-01 | 0.776 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.841430e-01 | 0.735 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.841430e-01 | 0.735 |
| R-HSA-68882 | Mitotic Anaphase | 2.138649e-01 | 0.670 |
| R-HSA-165159 | MTOR signalling | 2.083489e-01 | 0.681 |
| R-HSA-9843745 | Adipogenesis | 2.402460e-01 | 0.619 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.165308e-01 | 0.664 |
| R-HSA-74160 | Gene expression (Transcription) | 2.407003e-01 | 0.619 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 9.673485e-02 | 1.014 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 1.119252e-01 | 0.951 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.559861e-01 | 0.807 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.841430e-01 | 0.735 |
| R-HSA-9683686 | Maturation of spike protein | 1.978685e-01 | 0.704 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.978685e-01 | 0.704 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.376798e-01 | 0.624 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.376798e-01 | 0.624 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.755221e-01 | 0.560 |
| R-HSA-9694548 | Maturation of spike protein | 1.960622e-01 | 0.708 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.678552e-01 | 0.775 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.195770e-01 | 0.922 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.440664e-01 | 0.841 |
| R-HSA-5357801 | Programmed Cell Death | 1.853474e-01 | 0.732 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.481030e-01 | 0.829 |
| R-HSA-9675135 | Diseases of DNA repair | 2.331347e-01 | 0.632 |
| R-HSA-69275 | G2/M Transition | 2.692888e-01 | 0.570 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.268611e-01 | 0.897 |
| R-HSA-391906 | Leukotriene receptors | 1.415466e-01 | 0.849 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.559861e-01 | 0.807 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.841430e-01 | 0.735 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.113639e-01 | 0.675 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.505078e-01 | 0.601 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.631207e-01 | 0.580 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.631207e-01 | 0.580 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.755221e-01 | 0.560 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.755221e-01 | 0.560 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.838724e-01 | 0.735 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.757159e-01 | 0.560 |
| R-HSA-212436 | Generic Transcription Pathway | 1.190237e-01 | 0.924 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.021947e-01 | 0.694 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.803236e-01 | 0.744 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.130878e-01 | 0.947 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.701835e-01 | 0.769 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.631207e-01 | 0.580 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.455975e-01 | 0.610 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.465649e-01 | 0.608 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.978685e-01 | 0.704 |
| R-HSA-210990 | PECAM1 interactions | 2.113639e-01 | 0.675 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 2.580845e-01 | 0.588 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.622398e-01 | 0.581 |
| R-HSA-109581 | Apoptosis | 1.925662e-01 | 0.715 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.246351e-01 | 0.904 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.023154e-01 | 0.990 |
| R-HSA-9839394 | TGFBR3 expression | 9.790796e-02 | 1.009 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.505078e-01 | 0.601 |
| R-HSA-9707616 | Heme signaling | 1.172676e-01 | 0.931 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.209305e-01 | 0.917 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.539641e-01 | 0.813 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.539641e-01 | 0.813 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.589381e-01 | 0.799 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.516523e-01 | 0.819 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.113639e-01 | 0.675 |
| R-HSA-9830364 | Formation of the nephric duct | 9.790796e-02 | 1.009 |
| R-HSA-9909396 | Circadian clock | 2.438821e-01 | 0.613 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.774518e-01 | 0.751 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.701835e-01 | 0.769 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.631207e-01 | 0.580 |
| R-HSA-9833482 | PKR-mediated signaling | 1.887718e-01 | 0.724 |
| R-HSA-983712 | Ion channel transport | 2.789414e-01 | 0.554 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.845348e-01 | 0.734 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.484725e-01 | 0.828 |
| R-HSA-194138 | Signaling by VEGF | 2.151801e-01 | 0.667 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.598695e-01 | 0.796 |
| R-HSA-877300 | Interferon gamma signaling | 1.839296e-01 | 0.735 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.698682e-01 | 0.770 |
| R-HSA-913531 | Interferon Signaling | 1.518810e-01 | 0.818 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.145546e-01 | 0.941 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.021947e-01 | 0.694 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.539641e-01 | 0.813 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.365264e-01 | 0.865 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.331347e-01 | 0.632 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.705804e-01 | 0.568 |
| R-HSA-75153 | Apoptotic execution phase | 2.331347e-01 | 0.632 |
| R-HSA-157118 | Signaling by NOTCH | 1.557153e-01 | 0.808 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.186998e-01 | 0.926 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.830707e-01 | 0.548 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.866793e-01 | 0.543 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.877156e-01 | 0.541 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.877156e-01 | 0.541 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.877156e-01 | 0.541 |
| R-HSA-169893 | Prolonged ERK activation events | 2.877156e-01 | 0.541 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.877156e-01 | 0.541 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 2.877156e-01 | 0.541 |
| R-HSA-9945266 | Differentiation of T cells | 2.877156e-01 | 0.541 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.877156e-01 | 0.541 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.877156e-01 | 0.541 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.893096e-01 | 0.539 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.906772e-01 | 0.537 |
| R-HSA-68877 | Mitotic Prometaphase | 2.919174e-01 | 0.535 |
| R-HSA-6798695 | Neutrophil degranulation | 2.946052e-01 | 0.531 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.955420e-01 | 0.529 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.955420e-01 | 0.529 |
| R-HSA-177929 | Signaling by EGFR | 2.955420e-01 | 0.529 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.955420e-01 | 0.529 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.955420e-01 | 0.529 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.997046e-01 | 0.523 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.997046e-01 | 0.523 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.997046e-01 | 0.523 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.096445e-01 | 0.509 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.096445e-01 | 0.509 |
| R-HSA-166520 | Signaling by NTRKs | 3.110194e-01 | 0.507 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.114924e-01 | 0.507 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.114924e-01 | 0.507 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.114924e-01 | 0.507 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.114924e-01 | 0.507 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 3.114924e-01 | 0.507 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 3.114924e-01 | 0.507 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.119741e-01 | 0.506 |
| R-HSA-191859 | snRNP Assembly | 3.141860e-01 | 0.503 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.141860e-01 | 0.503 |
| R-HSA-180786 | Extension of Telomeres | 3.141860e-01 | 0.503 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.188519e-01 | 0.496 |
| R-HSA-180292 | GAB1 signalosome | 3.230826e-01 | 0.491 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.230826e-01 | 0.491 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.230826e-01 | 0.491 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.230826e-01 | 0.491 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.265566e-01 | 0.486 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.326683e-01 | 0.478 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.327203e-01 | 0.478 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.327203e-01 | 0.478 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.327203e-01 | 0.478 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.327203e-01 | 0.478 |
| R-HSA-1268020 | Mitochondrial protein import | 3.327203e-01 | 0.478 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.344784e-01 | 0.476 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.344784e-01 | 0.476 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 3.344784e-01 | 0.476 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 3.344784e-01 | 0.476 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.344784e-01 | 0.476 |
| R-HSA-392517 | Rap1 signalling | 3.344784e-01 | 0.476 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.344784e-01 | 0.476 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.344784e-01 | 0.476 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.344784e-01 | 0.476 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.372726e-01 | 0.472 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.388678e-01 | 0.470 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.388678e-01 | 0.470 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.388678e-01 | 0.470 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.388678e-01 | 0.470 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.456830e-01 | 0.461 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.456830e-01 | 0.461 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 3.456830e-01 | 0.461 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.456830e-01 | 0.461 |
| R-HSA-196108 | Pregnenolone biosynthesis | 3.456830e-01 | 0.461 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 3.456830e-01 | 0.461 |
| R-HSA-445144 | Signal transduction by L1 | 3.456830e-01 | 0.461 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 3.456830e-01 | 0.461 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.511098e-01 | 0.455 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.566997e-01 | 0.448 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 3.566997e-01 | 0.448 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.566997e-01 | 0.448 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.566997e-01 | 0.448 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.566997e-01 | 0.448 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.566997e-01 | 0.448 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.566997e-01 | 0.448 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.567531e-01 | 0.448 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.572020e-01 | 0.447 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.602564e-01 | 0.443 |
| R-HSA-1643685 | Disease | 3.630756e-01 | 0.440 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.632736e-01 | 0.440 |
| R-HSA-9830369 | Kidney development | 3.632736e-01 | 0.440 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.636841e-01 | 0.439 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.675316e-01 | 0.435 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.675316e-01 | 0.435 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.675316e-01 | 0.435 |
| R-HSA-9755088 | Ribavirin ADME | 3.675316e-01 | 0.435 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.693235e-01 | 0.433 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.753508e-01 | 0.426 |
| R-HSA-5663205 | Infectious disease | 3.770410e-01 | 0.424 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.781817e-01 | 0.422 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.781817e-01 | 0.422 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.781817e-01 | 0.422 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.781817e-01 | 0.422 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.781817e-01 | 0.422 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.781817e-01 | 0.422 |
| R-HSA-8964038 | LDL clearance | 3.781817e-01 | 0.422 |
| R-HSA-71384 | Ethanol oxidation | 3.781817e-01 | 0.422 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.781817e-01 | 0.422 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.813544e-01 | 0.419 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.813544e-01 | 0.419 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.813544e-01 | 0.419 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.873336e-01 | 0.412 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.873336e-01 | 0.412 |
| R-HSA-3000178 | ECM proteoglycans | 3.873336e-01 | 0.412 |
| R-HSA-8951664 | Neddylation | 3.880358e-01 | 0.411 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 3.886531e-01 | 0.410 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.886531e-01 | 0.410 |
| R-HSA-74182 | Ketone body metabolism | 3.886531e-01 | 0.410 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.932874e-01 | 0.405 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.986785e-01 | 0.399 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.989488e-01 | 0.399 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.992149e-01 | 0.399 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.992149e-01 | 0.399 |
| R-HSA-4086398 | Ca2+ pathway | 3.992149e-01 | 0.399 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.012855e-01 | 0.397 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.012855e-01 | 0.397 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.051155e-01 | 0.392 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.051155e-01 | 0.392 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.090718e-01 | 0.388 |
| R-HSA-2160916 | Hyaluronan degradation | 4.090718e-01 | 0.388 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 4.090718e-01 | 0.388 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.090718e-01 | 0.388 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.090718e-01 | 0.388 |
| R-HSA-3000157 | Laminin interactions | 4.090718e-01 | 0.388 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.090718e-01 | 0.388 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.090718e-01 | 0.388 |
| R-HSA-380287 | Centrosome maturation | 4.109882e-01 | 0.386 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.109882e-01 | 0.386 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.190249e-01 | 0.378 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 4.190249e-01 | 0.378 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.190249e-01 | 0.378 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 4.190249e-01 | 0.378 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.226475e-01 | 0.374 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.226475e-01 | 0.374 |
| R-HSA-69206 | G1/S Transition | 4.237722e-01 | 0.373 |
| R-HSA-72312 | rRNA processing | 4.246063e-01 | 0.372 |
| R-HSA-5619084 | ABC transporter disorders | 4.284327e-01 | 0.368 |
| R-HSA-4086400 | PCP/CE pathway | 4.284327e-01 | 0.368 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 4.288109e-01 | 0.368 |
| R-HSA-8949613 | Cristae formation | 4.288109e-01 | 0.368 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.288109e-01 | 0.368 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.288109e-01 | 0.368 |
| R-HSA-201451 | Signaling by BMP | 4.288109e-01 | 0.368 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.288109e-01 | 0.368 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.288109e-01 | 0.368 |
| R-HSA-264876 | Insulin processing | 4.288109e-01 | 0.368 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.288109e-01 | 0.368 |
| R-HSA-168255 | Influenza Infection | 4.326516e-01 | 0.364 |
| R-HSA-9659379 | Sensory processing of sound | 4.341873e-01 | 0.362 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.354519e-01 | 0.361 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.371270e-01 | 0.359 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.384327e-01 | 0.358 |
| R-HSA-622312 | Inflammasomes | 4.384327e-01 | 0.358 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.384327e-01 | 0.358 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.399107e-01 | 0.357 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.399107e-01 | 0.357 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.399107e-01 | 0.357 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.478930e-01 | 0.349 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.478930e-01 | 0.349 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.478930e-01 | 0.349 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.478930e-01 | 0.349 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.478930e-01 | 0.349 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.568886e-01 | 0.340 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.571945e-01 | 0.340 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.571945e-01 | 0.340 |
| R-HSA-2424491 | DAP12 signaling | 4.571945e-01 | 0.340 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.571945e-01 | 0.340 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.571945e-01 | 0.340 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.571945e-01 | 0.340 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.571945e-01 | 0.340 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.571945e-01 | 0.340 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.571945e-01 | 0.340 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.624820e-01 | 0.335 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.663399e-01 | 0.331 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.663399e-01 | 0.331 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.663399e-01 | 0.331 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.663399e-01 | 0.331 |
| R-HSA-182971 | EGFR downregulation | 4.663399e-01 | 0.331 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.663399e-01 | 0.331 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.663399e-01 | 0.331 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.663399e-01 | 0.331 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.663399e-01 | 0.331 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.680416e-01 | 0.330 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.735670e-01 | 0.325 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.735670e-01 | 0.325 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.753317e-01 | 0.323 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.753317e-01 | 0.323 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.790577e-01 | 0.320 |
| R-HSA-163685 | Integration of energy metabolism | 4.807416e-01 | 0.318 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.841726e-01 | 0.315 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.841726e-01 | 0.315 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.841726e-01 | 0.315 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.841726e-01 | 0.315 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.841726e-01 | 0.315 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.841726e-01 | 0.315 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.841726e-01 | 0.315 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.841726e-01 | 0.315 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.841726e-01 | 0.315 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.841726e-01 | 0.315 |
| R-HSA-9733709 | Cardiogenesis | 4.841726e-01 | 0.315 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.841726e-01 | 0.315 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.899337e-01 | 0.310 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.928651e-01 | 0.307 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 4.928651e-01 | 0.307 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.928651e-01 | 0.307 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 4.928651e-01 | 0.307 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.928651e-01 | 0.307 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.928651e-01 | 0.307 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.953182e-01 | 0.305 |
| R-HSA-202424 | Downstream TCR signaling | 5.006666e-01 | 0.300 |
| R-HSA-5673000 | RAF activation | 5.014115e-01 | 0.300 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.014115e-01 | 0.300 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.014115e-01 | 0.300 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.014115e-01 | 0.300 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.014115e-01 | 0.300 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.014115e-01 | 0.300 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.014115e-01 | 0.300 |
| R-HSA-392518 | Signal amplification | 5.014115e-01 | 0.300 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.014115e-01 | 0.300 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.098145e-01 | 0.293 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.098145e-01 | 0.293 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.098145e-01 | 0.293 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.098145e-01 | 0.293 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.098145e-01 | 0.293 |
| R-HSA-187687 | Signalling to ERKs | 5.098145e-01 | 0.293 |
| R-HSA-169911 | Regulation of Apoptosis | 5.098145e-01 | 0.293 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.098145e-01 | 0.293 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.103106e-01 | 0.292 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.144630e-01 | 0.289 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.164922e-01 | 0.287 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.164922e-01 | 0.287 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.180764e-01 | 0.286 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.180764e-01 | 0.286 |
| R-HSA-8853659 | RET signaling | 5.180764e-01 | 0.286 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.180764e-01 | 0.286 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.180764e-01 | 0.286 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 5.180764e-01 | 0.286 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.261995e-01 | 0.279 |
| R-HSA-4641258 | Degradation of DVL | 5.261995e-01 | 0.279 |
| R-HSA-4641257 | Degradation of AXIN | 5.261995e-01 | 0.279 |
| R-HSA-419037 | NCAM1 interactions | 5.261995e-01 | 0.279 |
| R-HSA-8948216 | Collagen chain trimerization | 5.261995e-01 | 0.279 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.268071e-01 | 0.278 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.292218e-01 | 0.276 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.319828e-01 | 0.274 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.319828e-01 | 0.274 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.341862e-01 | 0.272 |
| R-HSA-8875878 | MET promotes cell motility | 5.341862e-01 | 0.272 |
| R-HSA-74217 | Purine salvage | 5.341862e-01 | 0.272 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.341862e-01 | 0.272 |
| R-HSA-69242 | S Phase | 5.349399e-01 | 0.272 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.370709e-01 | 0.270 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.420387e-01 | 0.266 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.420387e-01 | 0.266 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.420387e-01 | 0.266 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.420387e-01 | 0.266 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 5.420387e-01 | 0.266 |
| R-HSA-9648002 | RAS processing | 5.420387e-01 | 0.266 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.420387e-01 | 0.266 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.421209e-01 | 0.266 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.421209e-01 | 0.266 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.469902e-01 | 0.262 |
| R-HSA-1474244 | Extracellular matrix organization | 5.480563e-01 | 0.261 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.497594e-01 | 0.260 |
| R-HSA-9646399 | Aggrephagy | 5.497594e-01 | 0.260 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.497594e-01 | 0.260 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.497594e-01 | 0.260 |
| R-HSA-202433 | Generation of second messenger molecules | 5.497594e-01 | 0.260 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.497594e-01 | 0.260 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 5.497594e-01 | 0.260 |
| R-HSA-8982491 | Glycogen metabolism | 5.497594e-01 | 0.260 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 5.497594e-01 | 0.260 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.497594e-01 | 0.260 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.509665e-01 | 0.259 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.509665e-01 | 0.259 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.509665e-01 | 0.259 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.521062e-01 | 0.258 |
| R-HSA-190236 | Signaling by FGFR | 5.521062e-01 | 0.258 |
| R-HSA-397014 | Muscle contraction | 5.547131e-01 | 0.256 |
| R-HSA-9609507 | Protein localization | 5.549222e-01 | 0.256 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.573503e-01 | 0.254 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.573503e-01 | 0.254 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.573503e-01 | 0.254 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.573503e-01 | 0.254 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.573503e-01 | 0.254 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.573503e-01 | 0.254 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.580976e-01 | 0.253 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.619375e-01 | 0.250 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.627713e-01 | 0.250 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.648138e-01 | 0.248 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.648138e-01 | 0.248 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.648138e-01 | 0.248 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.648138e-01 | 0.248 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.648138e-01 | 0.248 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.648138e-01 | 0.248 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.648138e-01 | 0.248 |
| R-HSA-9612973 | Autophagy | 5.666644e-01 | 0.247 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.667951e-01 | 0.247 |
| R-HSA-1483255 | PI Metabolism | 5.716140e-01 | 0.243 |
| R-HSA-991365 | Activation of GABAB receptors | 5.721518e-01 | 0.242 |
| R-HSA-977444 | GABA B receptor activation | 5.721518e-01 | 0.242 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.721518e-01 | 0.242 |
| R-HSA-9711097 | Cellular response to starvation | 5.743869e-01 | 0.241 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.793666e-01 | 0.237 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.793666e-01 | 0.237 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.793666e-01 | 0.237 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.811350e-01 | 0.236 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.821058e-01 | 0.235 |
| R-HSA-2172127 | DAP12 interactions | 5.864601e-01 | 0.232 |
| R-HSA-190828 | Gap junction trafficking | 5.864601e-01 | 0.232 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.864601e-01 | 0.232 |
| R-HSA-9907900 | Proteasome assembly | 5.864601e-01 | 0.232 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.864601e-01 | 0.232 |
| R-HSA-69236 | G1 Phase | 5.864601e-01 | 0.232 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.864601e-01 | 0.232 |
| R-HSA-112316 | Neuronal System | 5.894335e-01 | 0.230 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.905002e-01 | 0.229 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.934345e-01 | 0.227 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.934345e-01 | 0.227 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.934345e-01 | 0.227 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.934345e-01 | 0.227 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.934345e-01 | 0.227 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.934345e-01 | 0.227 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.934345e-01 | 0.227 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.934345e-01 | 0.227 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.934345e-01 | 0.227 |
| R-HSA-9824272 | Somitogenesis | 5.934345e-01 | 0.227 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 5.934345e-01 | 0.227 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.997092e-01 | 0.222 |
| R-HSA-69239 | Synthesis of DNA | 5.997092e-01 | 0.222 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 6.002916e-01 | 0.222 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.002916e-01 | 0.222 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.002916e-01 | 0.222 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.002916e-01 | 0.222 |
| R-HSA-1483191 | Synthesis of PC | 6.070335e-01 | 0.217 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.070335e-01 | 0.217 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.070335e-01 | 0.217 |
| R-HSA-168256 | Immune System | 6.101646e-01 | 0.215 |
| R-HSA-202403 | TCR signaling | 6.132301e-01 | 0.212 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.132301e-01 | 0.212 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.132301e-01 | 0.212 |
| R-HSA-5620924 | Intraflagellar transport | 6.136621e-01 | 0.212 |
| R-HSA-9634597 | GPER1 signaling | 6.136621e-01 | 0.212 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.201793e-01 | 0.207 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.220490e-01 | 0.206 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.220490e-01 | 0.206 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 6.265870e-01 | 0.203 |
| R-HSA-109704 | PI3K Cascade | 6.265870e-01 | 0.203 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.328869e-01 | 0.199 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 6.328869e-01 | 0.199 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.349861e-01 | 0.197 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.390809e-01 | 0.194 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.390809e-01 | 0.194 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.390809e-01 | 0.194 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.390809e-01 | 0.194 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.390809e-01 | 0.194 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.451708e-01 | 0.190 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.451708e-01 | 0.190 |
| R-HSA-72649 | Translation initiation complex formation | 6.511584e-01 | 0.186 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.511584e-01 | 0.186 |
| R-HSA-156588 | Glucuronidation | 6.511584e-01 | 0.186 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.516948e-01 | 0.186 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.516948e-01 | 0.186 |
| R-HSA-418597 | G alpha (z) signalling events | 6.570452e-01 | 0.182 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.598190e-01 | 0.181 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.628331e-01 | 0.179 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.628331e-01 | 0.179 |
| R-HSA-5578775 | Ion homeostasis | 6.628331e-01 | 0.179 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.685236e-01 | 0.175 |
| R-HSA-112399 | IRS-mediated signalling | 6.685236e-01 | 0.175 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.685236e-01 | 0.175 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.741184e-01 | 0.171 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.796192e-01 | 0.168 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.796192e-01 | 0.168 |
| R-HSA-977443 | GABA receptor activation | 6.850274e-01 | 0.164 |
| R-HSA-379724 | tRNA Aminoacylation | 6.850274e-01 | 0.164 |
| R-HSA-983189 | Kinesins | 6.850274e-01 | 0.164 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.850274e-01 | 0.164 |
| R-HSA-351202 | Metabolism of polyamines | 6.850274e-01 | 0.164 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.903447e-01 | 0.161 |
| R-HSA-8956321 | Nucleotide salvage | 6.903447e-01 | 0.161 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.903447e-01 | 0.161 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.903447e-01 | 0.161 |
| R-HSA-1442490 | Collagen degradation | 6.903447e-01 | 0.161 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.955725e-01 | 0.158 |
| R-HSA-186797 | Signaling by PDGF | 6.955725e-01 | 0.158 |
| R-HSA-936837 | Ion transport by P-type ATPases | 7.057658e-01 | 0.151 |
| R-HSA-2428924 | IGF1R signaling cascade | 7.057658e-01 | 0.151 |
| R-HSA-74751 | Insulin receptor signalling cascade | 7.057658e-01 | 0.151 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 7.107342e-01 | 0.148 |
| R-HSA-5576891 | Cardiac conduction | 7.124964e-01 | 0.147 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.159854e-01 | 0.145 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.204216e-01 | 0.142 |
| R-HSA-112040 | G-protein mediated events | 7.204216e-01 | 0.142 |
| R-HSA-196071 | Metabolism of steroid hormones | 7.204216e-01 | 0.142 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.205975e-01 | 0.142 |
| R-HSA-5218859 | Regulated Necrosis | 7.251434e-01 | 0.140 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 7.251434e-01 | 0.140 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.271910e-01 | 0.138 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.343499e-01 | 0.134 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 7.343499e-01 | 0.134 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.343499e-01 | 0.134 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.361806e-01 | 0.133 |
| R-HSA-8978934 | Metabolism of cofactors | 7.388373e-01 | 0.131 |
| R-HSA-6807070 | PTEN Regulation | 7.426361e-01 | 0.129 |
| R-HSA-74259 | Purine catabolism | 7.432492e-01 | 0.129 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.475868e-01 | 0.126 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.560441e-01 | 0.121 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.682037e-01 | 0.115 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.700391e-01 | 0.113 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.721212e-01 | 0.112 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.729221e-01 | 0.112 |
| R-HSA-72766 | Translation | 7.762671e-01 | 0.110 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.797593e-01 | 0.108 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.834822e-01 | 0.106 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.871424e-01 | 0.104 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.907409e-01 | 0.102 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.942788e-01 | 0.100 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.000606e-01 | 0.097 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 8.011767e-01 | 0.096 |
| R-HSA-70268 | Pyruvate metabolism | 8.045388e-01 | 0.094 |
| R-HSA-156902 | Peptide chain elongation | 8.078443e-01 | 0.093 |
| R-HSA-9663891 | Selective autophagy | 8.078443e-01 | 0.093 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.119900e-01 | 0.090 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.142890e-01 | 0.089 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.149331e-01 | 0.089 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.174301e-01 | 0.088 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.205183e-01 | 0.086 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.235544e-01 | 0.084 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.235544e-01 | 0.084 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.235544e-01 | 0.084 |
| R-HSA-1474290 | Collagen formation | 8.294741e-01 | 0.081 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.317199e-01 | 0.080 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.332264e-01 | 0.079 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.351958e-01 | 0.078 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.351958e-01 | 0.078 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.357197e-01 | 0.078 |
| R-HSA-8957322 | Metabolism of steroids | 8.361126e-01 | 0.078 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.379845e-01 | 0.077 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.379845e-01 | 0.077 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.417492e-01 | 0.075 |
| R-HSA-422356 | Regulation of insulin secretion | 8.434217e-01 | 0.074 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.434217e-01 | 0.074 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.434217e-01 | 0.074 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.434217e-01 | 0.074 |
| R-HSA-70171 | Glycolysis | 8.486771e-01 | 0.071 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.512385e-01 | 0.070 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.512385e-01 | 0.070 |
| R-HSA-192823 | Viral mRNA Translation | 8.562324e-01 | 0.067 |
| R-HSA-111885 | Opioid Signalling | 8.586663e-01 | 0.066 |
| R-HSA-9833110 | RSV-host interactions | 8.610592e-01 | 0.065 |
| R-HSA-418346 | Platelet homeostasis | 8.657246e-01 | 0.063 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.702339e-01 | 0.060 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.702339e-01 | 0.060 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.702339e-01 | 0.060 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.720344e-01 | 0.059 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.724316e-01 | 0.059 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.763444e-01 | 0.057 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.770847e-01 | 0.057 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.788048e-01 | 0.056 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.808579e-01 | 0.055 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.833560e-01 | 0.054 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.868115e-01 | 0.052 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.868115e-01 | 0.052 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.887295e-01 | 0.051 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.896689e-01 | 0.051 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.906150e-01 | 0.050 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.906150e-01 | 0.050 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.911553e-01 | 0.050 |
| R-HSA-70326 | Glucose metabolism | 8.924687e-01 | 0.049 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.924687e-01 | 0.049 |
| R-HSA-72172 | mRNA Splicing | 8.940728e-01 | 0.049 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.960828e-01 | 0.048 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.960828e-01 | 0.048 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.995758e-01 | 0.046 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 9.012781e-01 | 0.045 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 9.012781e-01 | 0.045 |
| R-HSA-1483257 | Phospholipid metabolism | 9.034771e-01 | 0.044 |
| R-HSA-6809371 | Formation of the cornified envelope | 9.045971e-01 | 0.044 |
| R-HSA-114608 | Platelet degranulation | 9.109052e-01 | 0.041 |
| R-HSA-8956319 | Nucleotide catabolism | 9.139017e-01 | 0.039 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.195966e-01 | 0.036 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.209607e-01 | 0.036 |
| R-HSA-168249 | Innate Immune System | 9.235913e-01 | 0.035 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.249037e-01 | 0.034 |
| R-HSA-388396 | GPCR downstream signalling | 9.253256e-01 | 0.034 |
| R-HSA-109582 | Hemostasis | 9.313835e-01 | 0.031 |
| R-HSA-1632852 | Macroautophagy | 9.322451e-01 | 0.030 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 9.322451e-01 | 0.030 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.367306e-01 | 0.028 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.429100e-01 | 0.026 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.436534e-01 | 0.025 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.450833e-01 | 0.025 |
| R-HSA-5619102 | SLC transporter disorders | 9.573414e-01 | 0.019 |
| R-HSA-72306 | tRNA processing | 9.601701e-01 | 0.018 |
| R-HSA-418555 | G alpha (s) signalling events | 9.608476e-01 | 0.017 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.621683e-01 | 0.017 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.621683e-01 | 0.017 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.624999e-01 | 0.017 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.628119e-01 | 0.016 |
| R-HSA-372790 | Signaling by GPCR | 9.640844e-01 | 0.016 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.640879e-01 | 0.016 |
| R-HSA-9658195 | Leishmania infection | 9.640879e-01 | 0.016 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.697346e-01 | 0.013 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.710784e-01 | 0.013 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.731632e-01 | 0.012 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.762046e-01 | 0.010 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.774006e-01 | 0.010 |
| R-HSA-6805567 | Keratinization | 9.789025e-01 | 0.009 |
| R-HSA-9748784 | Drug ADME | 9.828373e-01 | 0.008 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.860404e-01 | 0.006 |
| R-HSA-15869 | Metabolism of nucleotides | 9.874110e-01 | 0.006 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.878773e-01 | 0.005 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.880451e-01 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 9.892655e-01 | 0.005 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.894514e-01 | 0.005 |
| R-HSA-416476 | G alpha (q) signalling events | 9.922318e-01 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.934028e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.945903e-01 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.950580e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.952890e-01 | 0.002 |
| R-HSA-449147 | Signaling by Interleukins | 9.954959e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.993525e-01 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 9.993601e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.995484e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.996899e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.892 | 0.114 | 2 | 0.882 |
PIM3 |
0.885 | 0.123 | -3 | 0.853 |
TGFBR2 |
0.882 | 0.153 | -2 | 0.827 |
ULK2 |
0.882 | 0.001 | 2 | 0.833 |
NEK6 |
0.881 | 0.117 | -2 | 0.886 |
DSTYK |
0.881 | 0.084 | 2 | 0.893 |
RSK2 |
0.881 | 0.164 | -3 | 0.790 |
NLK |
0.880 | 0.090 | 1 | 0.844 |
PKN3 |
0.880 | 0.131 | -3 | 0.849 |
PKN2 |
0.880 | 0.192 | -3 | 0.860 |
RAF1 |
0.880 | -0.018 | 1 | 0.916 |
WNK1 |
0.880 | 0.133 | -2 | 0.853 |
TBK1 |
0.880 | 0.009 | 1 | 0.846 |
CAMK1B |
0.879 | 0.088 | -3 | 0.869 |
GCN2 |
0.879 | -0.073 | 2 | 0.837 |
MST4 |
0.879 | 0.161 | 2 | 0.895 |
PRPK |
0.879 | -0.142 | -1 | 0.884 |
NEK7 |
0.878 | 0.035 | -3 | 0.850 |
PKCD |
0.878 | 0.193 | 2 | 0.855 |
RSK3 |
0.878 | 0.134 | -3 | 0.788 |
CDKL1 |
0.878 | 0.097 | -3 | 0.815 |
CDC7 |
0.877 | -0.028 | 1 | 0.852 |
PRKD1 |
0.877 | 0.153 | -3 | 0.872 |
PRKD2 |
0.877 | 0.173 | -3 | 0.810 |
IKKE |
0.877 | -0.003 | 1 | 0.844 |
NIK |
0.876 | 0.126 | -3 | 0.891 |
NDR1 |
0.876 | 0.082 | -3 | 0.854 |
P90RSK |
0.876 | 0.115 | -3 | 0.797 |
BMPR2 |
0.876 | -0.018 | -2 | 0.896 |
CDKL5 |
0.876 | 0.126 | -3 | 0.813 |
MLK1 |
0.875 | 0.058 | 2 | 0.868 |
IKKB |
0.875 | -0.091 | -2 | 0.767 |
NEK9 |
0.875 | 0.077 | 2 | 0.896 |
MOS |
0.874 | -0.042 | 1 | 0.876 |
PDHK1 |
0.874 | -0.100 | 1 | 0.911 |
NUAK2 |
0.874 | 0.096 | -3 | 0.853 |
CLK3 |
0.874 | 0.134 | 1 | 0.811 |
NDR2 |
0.874 | 0.026 | -3 | 0.863 |
MAPKAPK3 |
0.873 | 0.092 | -3 | 0.822 |
PIM1 |
0.873 | 0.140 | -3 | 0.798 |
P70S6KB |
0.873 | 0.119 | -3 | 0.815 |
CAMLCK |
0.873 | 0.074 | -2 | 0.859 |
AMPKA1 |
0.873 | 0.098 | -3 | 0.878 |
PDHK4 |
0.873 | -0.249 | 1 | 0.906 |
SRPK1 |
0.872 | 0.143 | -3 | 0.772 |
RIPK3 |
0.872 | -0.003 | 3 | 0.743 |
MTOR |
0.872 | -0.137 | 1 | 0.827 |
ATR |
0.871 | -0.041 | 1 | 0.848 |
PKACG |
0.871 | 0.114 | -2 | 0.798 |
ERK5 |
0.871 | 0.047 | 1 | 0.815 |
CAMK2G |
0.870 | -0.093 | 2 | 0.785 |
PKCA |
0.870 | 0.185 | 2 | 0.813 |
IRE1 |
0.870 | 0.100 | 1 | 0.845 |
TSSK2 |
0.870 | 0.141 | -5 | 0.844 |
ULK1 |
0.870 | -0.090 | -3 | 0.821 |
DAPK2 |
0.869 | 0.044 | -3 | 0.880 |
NEK2 |
0.869 | 0.121 | 2 | 0.880 |
PRKD3 |
0.869 | 0.162 | -3 | 0.779 |
PKG2 |
0.869 | 0.177 | -2 | 0.739 |
TSSK1 |
0.868 | 0.136 | -3 | 0.896 |
PKCB |
0.868 | 0.158 | 2 | 0.819 |
WNK3 |
0.868 | -0.095 | 1 | 0.887 |
IRE2 |
0.868 | 0.124 | 2 | 0.812 |
MLK3 |
0.867 | 0.117 | 2 | 0.815 |
ANKRD3 |
0.867 | 0.028 | 1 | 0.935 |
PHKG1 |
0.867 | 0.110 | -3 | 0.856 |
CHAK2 |
0.867 | -0.014 | -1 | 0.829 |
PKCG |
0.867 | 0.145 | 2 | 0.809 |
SRPK2 |
0.867 | 0.139 | -3 | 0.695 |
HUNK |
0.867 | -0.063 | 2 | 0.830 |
MELK |
0.867 | 0.091 | -3 | 0.841 |
AMPKA2 |
0.866 | 0.080 | -3 | 0.848 |
CAMK2D |
0.866 | 0.008 | -3 | 0.874 |
MARK4 |
0.866 | -0.012 | 4 | 0.830 |
CAMK4 |
0.866 | 0.046 | -3 | 0.840 |
SRPK3 |
0.866 | 0.147 | -3 | 0.737 |
AURC |
0.866 | 0.099 | -2 | 0.686 |
MLK2 |
0.866 | -0.006 | 2 | 0.875 |
GRK5 |
0.865 | -0.144 | -3 | 0.839 |
ICK |
0.865 | 0.046 | -3 | 0.855 |
LATS2 |
0.865 | 0.004 | -5 | 0.766 |
PIM2 |
0.865 | 0.171 | -3 | 0.769 |
PKCH |
0.865 | 0.137 | 2 | 0.803 |
PLK1 |
0.865 | 0.069 | -2 | 0.862 |
BCKDK |
0.864 | -0.111 | -1 | 0.827 |
SKMLCK |
0.864 | -0.016 | -2 | 0.842 |
DLK |
0.864 | -0.069 | 1 | 0.907 |
MNK2 |
0.863 | 0.081 | -2 | 0.807 |
PAK6 |
0.863 | 0.121 | -2 | 0.721 |
PKR |
0.863 | 0.130 | 1 | 0.895 |
PAK3 |
0.863 | 0.019 | -2 | 0.790 |
SGK3 |
0.863 | 0.153 | -3 | 0.795 |
HRI |
0.862 | 0.120 | -2 | 0.885 |
QIK |
0.862 | 0.013 | -3 | 0.859 |
NIM1 |
0.861 | -0.043 | 3 | 0.797 |
AURB |
0.861 | 0.080 | -2 | 0.684 |
YSK4 |
0.861 | 0.027 | 1 | 0.861 |
NUAK1 |
0.861 | 0.041 | -3 | 0.812 |
RSK4 |
0.861 | 0.116 | -3 | 0.761 |
GRK6 |
0.860 | -0.060 | 1 | 0.898 |
RIPK1 |
0.860 | -0.111 | 1 | 0.890 |
MASTL |
0.860 | -0.253 | -2 | 0.823 |
CHAK1 |
0.860 | 0.020 | 2 | 0.843 |
MAPKAPK2 |
0.860 | 0.049 | -3 | 0.766 |
PKCZ |
0.860 | 0.068 | 2 | 0.851 |
MLK4 |
0.860 | 0.052 | 2 | 0.787 |
HIPK4 |
0.860 | 0.017 | 1 | 0.788 |
AKT2 |
0.859 | 0.133 | -3 | 0.711 |
ALK4 |
0.859 | 0.040 | -2 | 0.833 |
PAK1 |
0.859 | 0.007 | -2 | 0.784 |
IKKA |
0.858 | -0.094 | -2 | 0.755 |
CLK1 |
0.858 | 0.115 | -3 | 0.765 |
QSK |
0.857 | 0.038 | 4 | 0.815 |
MSK2 |
0.857 | 0.002 | -3 | 0.771 |
PHKG2 |
0.857 | 0.130 | -3 | 0.819 |
TTBK2 |
0.857 | -0.141 | 2 | 0.750 |
PKACB |
0.857 | 0.104 | -2 | 0.721 |
SIK |
0.856 | 0.036 | -3 | 0.790 |
MNK1 |
0.856 | 0.069 | -2 | 0.826 |
LATS1 |
0.856 | 0.038 | -3 | 0.866 |
MYLK4 |
0.856 | 0.049 | -2 | 0.778 |
BMPR1B |
0.855 | 0.094 | 1 | 0.829 |
PKCT |
0.855 | 0.131 | 2 | 0.813 |
ACVR2A |
0.854 | 0.073 | -2 | 0.826 |
VRK2 |
0.854 | -0.079 | 1 | 0.918 |
MST3 |
0.854 | 0.170 | 2 | 0.891 |
PERK |
0.854 | 0.034 | -2 | 0.857 |
GRK4 |
0.854 | -0.153 | -2 | 0.813 |
MEK1 |
0.854 | -0.102 | 2 | 0.858 |
IRAK4 |
0.854 | 0.078 | 1 | 0.867 |
TGFBR1 |
0.854 | 0.034 | -2 | 0.802 |
AKT1 |
0.854 | 0.138 | -3 | 0.737 |
CLK4 |
0.854 | 0.065 | -3 | 0.781 |
PAK2 |
0.854 | -0.022 | -2 | 0.772 |
CHK1 |
0.854 | 0.043 | -3 | 0.846 |
P70S6K |
0.853 | 0.100 | -3 | 0.734 |
MSK1 |
0.853 | 0.045 | -3 | 0.778 |
CAMK2B |
0.852 | -0.014 | 2 | 0.729 |
PKCI |
0.852 | 0.132 | 2 | 0.823 |
BRSK2 |
0.852 | -0.025 | -3 | 0.852 |
NEK5 |
0.852 | 0.061 | 1 | 0.895 |
CAMK2A |
0.851 | 0.008 | 2 | 0.760 |
WNK4 |
0.851 | 0.011 | -2 | 0.846 |
MEKK1 |
0.851 | -0.001 | 1 | 0.902 |
ZAK |
0.851 | 0.021 | 1 | 0.879 |
CDK5 |
0.851 | 0.046 | 1 | 0.662 |
GRK1 |
0.851 | -0.083 | -2 | 0.766 |
BRSK1 |
0.851 | -0.009 | -3 | 0.825 |
AURA |
0.850 | 0.031 | -2 | 0.636 |
ACVR2B |
0.850 | 0.043 | -2 | 0.835 |
ATM |
0.850 | -0.082 | 1 | 0.783 |
SNRK |
0.850 | -0.107 | 2 | 0.706 |
SMMLCK |
0.849 | 0.067 | -3 | 0.835 |
KIS |
0.849 | -0.042 | 1 | 0.676 |
CAMK1G |
0.849 | 0.029 | -3 | 0.783 |
BRAF |
0.849 | -0.022 | -4 | 0.804 |
SMG1 |
0.849 | -0.041 | 1 | 0.791 |
CDK8 |
0.849 | -0.062 | 1 | 0.648 |
MAPKAPK5 |
0.849 | -0.048 | -3 | 0.758 |
PKCE |
0.848 | 0.176 | 2 | 0.802 |
MARK3 |
0.848 | 0.003 | 4 | 0.775 |
CDK2 |
0.848 | 0.025 | 1 | 0.703 |
PRKX |
0.848 | 0.127 | -3 | 0.704 |
MEK5 |
0.848 | -0.093 | 2 | 0.861 |
MEKK2 |
0.848 | 0.015 | 2 | 0.856 |
MARK2 |
0.848 | -0.012 | 4 | 0.728 |
ALK2 |
0.848 | 0.011 | -2 | 0.810 |
PLK3 |
0.848 | -0.063 | 2 | 0.737 |
PKACA |
0.848 | 0.106 | -2 | 0.680 |
DRAK1 |
0.848 | -0.016 | 1 | 0.831 |
DCAMKL1 |
0.847 | 0.021 | -3 | 0.817 |
PLK4 |
0.847 | -0.055 | 2 | 0.648 |
EEF2K |
0.847 | 0.202 | 3 | 0.899 |
P38A |
0.846 | 0.006 | 1 | 0.691 |
PKN1 |
0.846 | 0.131 | -3 | 0.755 |
CDK7 |
0.846 | -0.055 | 1 | 0.644 |
TLK2 |
0.846 | -0.100 | 1 | 0.859 |
TAO2 |
0.846 | 0.116 | 2 | 0.899 |
DNAPK |
0.846 | -0.032 | 1 | 0.737 |
SSTK |
0.845 | 0.072 | 4 | 0.817 |
DYRK2 |
0.845 | -0.023 | 1 | 0.694 |
MARK1 |
0.845 | -0.028 | 4 | 0.796 |
CDK19 |
0.844 | -0.048 | 1 | 0.605 |
CDK1 |
0.844 | 0.007 | 1 | 0.600 |
TAO3 |
0.844 | 0.045 | 1 | 0.870 |
DCAMKL2 |
0.844 | 0.019 | -3 | 0.833 |
MEKK3 |
0.844 | -0.113 | 1 | 0.894 |
HGK |
0.844 | 0.180 | 3 | 0.904 |
CDK13 |
0.844 | -0.041 | 1 | 0.616 |
PRP4 |
0.844 | 0.046 | -3 | 0.800 |
NEK8 |
0.843 | 0.009 | 2 | 0.871 |
NEK4 |
0.843 | 0.090 | 1 | 0.880 |
FAM20C |
0.843 | -0.061 | 2 | 0.505 |
PAK5 |
0.843 | 0.041 | -2 | 0.660 |
TLK1 |
0.843 | -0.053 | -2 | 0.836 |
HIPK3 |
0.842 | 0.023 | 1 | 0.728 |
LOK |
0.842 | 0.146 | -2 | 0.822 |
TNIK |
0.842 | 0.200 | 3 | 0.902 |
CAMKK1 |
0.842 | -0.023 | -2 | 0.782 |
CDK18 |
0.842 | -0.004 | 1 | 0.568 |
GRK7 |
0.842 | -0.033 | 1 | 0.814 |
BUB1 |
0.842 | 0.282 | -5 | 0.822 |
AKT3 |
0.841 | 0.129 | -3 | 0.656 |
HIPK1 |
0.841 | 0.024 | 1 | 0.711 |
PINK1 |
0.841 | -0.125 | 1 | 0.828 |
IRAK1 |
0.840 | -0.105 | -1 | 0.795 |
CLK2 |
0.840 | 0.098 | -3 | 0.770 |
CDK9 |
0.840 | -0.054 | 1 | 0.629 |
JNK2 |
0.840 | -0.012 | 1 | 0.596 |
CDK14 |
0.840 | 0.019 | 1 | 0.625 |
MINK |
0.840 | 0.142 | 1 | 0.889 |
GCK |
0.839 | 0.107 | 1 | 0.889 |
NEK11 |
0.839 | -0.055 | 1 | 0.882 |
CHK2 |
0.839 | 0.096 | -3 | 0.664 |
CAMK1D |
0.839 | 0.045 | -3 | 0.725 |
DYRK1A |
0.839 | -0.005 | 1 | 0.726 |
NEK1 |
0.838 | 0.121 | 1 | 0.882 |
CAMKK2 |
0.838 | -0.025 | -2 | 0.778 |
P38B |
0.838 | -0.013 | 1 | 0.613 |
CDK10 |
0.838 | 0.066 | 1 | 0.606 |
CDK12 |
0.838 | -0.039 | 1 | 0.592 |
MRCKB |
0.837 | 0.121 | -3 | 0.765 |
HPK1 |
0.837 | 0.130 | 1 | 0.879 |
JNK3 |
0.837 | -0.051 | 1 | 0.629 |
MEKK6 |
0.837 | 0.044 | 1 | 0.872 |
MPSK1 |
0.837 | 0.038 | 1 | 0.814 |
ERK1 |
0.837 | -0.035 | 1 | 0.602 |
BMPR1A |
0.837 | 0.039 | 1 | 0.808 |
PAK4 |
0.837 | 0.033 | -2 | 0.654 |
ERK2 |
0.836 | -0.067 | 1 | 0.649 |
TTBK1 |
0.836 | -0.124 | 2 | 0.658 |
GRK2 |
0.836 | -0.097 | -2 | 0.707 |
LKB1 |
0.836 | -0.022 | -3 | 0.875 |
CDK3 |
0.836 | 0.051 | 1 | 0.531 |
MRCKA |
0.836 | 0.104 | -3 | 0.779 |
KHS1 |
0.836 | 0.169 | 1 | 0.876 |
MST2 |
0.835 | 0.017 | 1 | 0.900 |
SGK1 |
0.835 | 0.112 | -3 | 0.635 |
YSK1 |
0.834 | 0.121 | 2 | 0.879 |
CDK16 |
0.834 | 0.031 | 1 | 0.530 |
PASK |
0.834 | -0.040 | -3 | 0.863 |
HIPK2 |
0.834 | 0.002 | 1 | 0.589 |
KHS2 |
0.834 | 0.184 | 1 | 0.882 |
P38G |
0.834 | -0.034 | 1 | 0.511 |
ERK7 |
0.834 | 0.072 | 2 | 0.618 |
PDK1 |
0.834 | -0.036 | 1 | 0.871 |
CDK17 |
0.833 | -0.043 | 1 | 0.514 |
ROCK2 |
0.833 | 0.122 | -3 | 0.816 |
MST1 |
0.833 | 0.061 | 1 | 0.888 |
TAK1 |
0.833 | 0.020 | 1 | 0.892 |
DAPK3 |
0.833 | 0.025 | -3 | 0.821 |
CAMK1A |
0.832 | 0.081 | -3 | 0.686 |
PKG1 |
0.832 | 0.116 | -2 | 0.661 |
LRRK2 |
0.831 | -0.020 | 2 | 0.885 |
CDK6 |
0.831 | 0.047 | 1 | 0.601 |
MAP3K15 |
0.831 | -0.027 | 1 | 0.857 |
GAK |
0.831 | -0.013 | 1 | 0.874 |
DYRK3 |
0.830 | 0.008 | 1 | 0.724 |
SLK |
0.830 | 0.018 | -2 | 0.767 |
NEK3 |
0.830 | 0.053 | 1 | 0.852 |
VRK1 |
0.830 | -0.018 | 2 | 0.873 |
GSK3B |
0.830 | -0.043 | 4 | 0.416 |
RIPK2 |
0.829 | -0.110 | 1 | 0.845 |
CDK4 |
0.827 | 0.020 | 1 | 0.575 |
DYRK1B |
0.827 | -0.035 | 1 | 0.639 |
DMPK1 |
0.826 | 0.134 | -3 | 0.775 |
DAPK1 |
0.825 | 0.007 | -3 | 0.800 |
PBK |
0.825 | 0.057 | 1 | 0.800 |
MEK2 |
0.825 | -0.122 | 2 | 0.850 |
CK1E |
0.824 | -0.111 | -3 | 0.503 |
ROCK1 |
0.824 | 0.115 | -3 | 0.782 |
STK33 |
0.824 | -0.122 | 2 | 0.635 |
MYO3B |
0.823 | 0.150 | 2 | 0.887 |
P38D |
0.822 | -0.027 | 1 | 0.516 |
MOK |
0.822 | 0.075 | 1 | 0.730 |
TTK |
0.822 | 0.106 | -2 | 0.851 |
DYRK4 |
0.821 | -0.047 | 1 | 0.601 |
GSK3A |
0.819 | -0.056 | 4 | 0.424 |
MYO3A |
0.819 | 0.127 | 1 | 0.868 |
MAK |
0.819 | 0.063 | -2 | 0.714 |
OSR1 |
0.819 | 0.029 | 2 | 0.852 |
GRK3 |
0.819 | -0.109 | -2 | 0.655 |
CK1G1 |
0.818 | -0.118 | -3 | 0.491 |
TAO1 |
0.818 | 0.075 | 1 | 0.819 |
CRIK |
0.818 | 0.111 | -3 | 0.732 |
CK1A2 |
0.818 | -0.089 | -3 | 0.455 |
CK1D |
0.817 | -0.105 | -3 | 0.457 |
CK2A2 |
0.816 | -0.012 | 1 | 0.704 |
SBK |
0.814 | 0.018 | -3 | 0.598 |
PLK2 |
0.813 | -0.104 | -3 | 0.723 |
BIKE |
0.812 | 0.077 | 1 | 0.745 |
HASPIN |
0.811 | 0.016 | -1 | 0.675 |
ASK1 |
0.808 | -0.074 | 1 | 0.839 |
JNK1 |
0.806 | -0.096 | 1 | 0.574 |
CK2A1 |
0.806 | -0.031 | 1 | 0.685 |
PDHK3_TYR |
0.804 | 0.091 | 4 | 0.884 |
TESK1_TYR |
0.800 | 0.015 | 3 | 0.905 |
STLK3 |
0.800 | -0.106 | 1 | 0.850 |
LIMK2_TYR |
0.799 | 0.110 | -3 | 0.915 |
PKMYT1_TYR |
0.797 | -0.035 | 3 | 0.865 |
MAP2K7_TYR |
0.795 | -0.167 | 2 | 0.865 |
MAP2K4_TYR |
0.795 | -0.109 | -1 | 0.895 |
PINK1_TYR |
0.795 | -0.068 | 1 | 0.878 |
AAK1 |
0.795 | 0.110 | 1 | 0.631 |
TYK2 |
0.794 | 0.026 | 1 | 0.885 |
RET |
0.794 | 0.011 | 1 | 0.881 |
ROS1 |
0.792 | 0.034 | 3 | 0.777 |
BMPR2_TYR |
0.792 | -0.052 | -1 | 0.879 |
TNNI3K_TYR |
0.792 | 0.182 | 1 | 0.899 |
TYRO3 |
0.792 | 0.025 | 3 | 0.813 |
EPHA6 |
0.792 | 0.042 | -1 | 0.895 |
MAP2K6_TYR |
0.791 | -0.139 | -1 | 0.893 |
ALPHAK3 |
0.791 | -0.164 | -1 | 0.793 |
LIMK1_TYR |
0.791 | -0.057 | 2 | 0.886 |
PDHK4_TYR |
0.790 | -0.128 | 2 | 0.864 |
YANK3 |
0.790 | -0.123 | 2 | 0.384 |
MST1R |
0.789 | -0.037 | 3 | 0.805 |
EPHB4 |
0.789 | 0.009 | -1 | 0.892 |
JAK2 |
0.788 | -0.018 | 1 | 0.881 |
PDHK1_TYR |
0.788 | -0.163 | -1 | 0.907 |
FGR |
0.786 | -0.009 | 1 | 0.908 |
ABL2 |
0.785 | 0.015 | -1 | 0.874 |
ITK |
0.785 | 0.056 | -1 | 0.867 |
TXK |
0.785 | 0.087 | 1 | 0.879 |
JAK1 |
0.785 | 0.080 | 1 | 0.844 |
CSF1R |
0.785 | -0.054 | 3 | 0.788 |
PDGFRB |
0.784 | -0.022 | 3 | 0.814 |
DDR1 |
0.784 | -0.108 | 4 | 0.820 |
YES1 |
0.783 | -0.010 | -1 | 0.898 |
TNK1 |
0.782 | 0.007 | 3 | 0.787 |
JAK3 |
0.782 | -0.072 | 1 | 0.853 |
HCK |
0.782 | 0.005 | -1 | 0.893 |
TNK2 |
0.782 | -0.011 | 3 | 0.745 |
NEK10_TYR |
0.782 | -0.010 | 1 | 0.736 |
ABL1 |
0.781 | -0.003 | -1 | 0.870 |
LCK |
0.781 | 0.063 | -1 | 0.892 |
EPHB1 |
0.780 | -0.024 | 1 | 0.913 |
TEC |
0.780 | 0.042 | -1 | 0.818 |
FLT3 |
0.779 | -0.057 | 3 | 0.814 |
FER |
0.778 | -0.146 | 1 | 0.904 |
WEE1_TYR |
0.778 | 0.026 | -1 | 0.792 |
INSRR |
0.777 | -0.109 | 3 | 0.749 |
AXL |
0.777 | -0.051 | 3 | 0.761 |
BTK |
0.776 | -0.046 | -1 | 0.843 |
PDGFRA |
0.776 | -0.094 | 3 | 0.809 |
KDR |
0.776 | -0.075 | 3 | 0.748 |
EPHB3 |
0.776 | -0.062 | -1 | 0.886 |
BLK |
0.776 | 0.037 | -1 | 0.890 |
ALK |
0.775 | -0.055 | 3 | 0.722 |
BMX |
0.775 | 0.001 | -1 | 0.793 |
SRMS |
0.775 | -0.091 | 1 | 0.905 |
EPHB2 |
0.774 | -0.052 | -1 | 0.883 |
KIT |
0.774 | -0.127 | 3 | 0.799 |
MERTK |
0.774 | -0.050 | 3 | 0.759 |
TEK |
0.772 | -0.129 | 3 | 0.747 |
FGFR2 |
0.772 | -0.172 | 3 | 0.786 |
LTK |
0.772 | -0.069 | 3 | 0.737 |
EPHA4 |
0.772 | -0.108 | 2 | 0.727 |
FGFR1 |
0.771 | -0.149 | 3 | 0.758 |
CK1A |
0.771 | -0.158 | -3 | 0.361 |
PTK6 |
0.770 | -0.149 | -1 | 0.802 |
EPHA1 |
0.769 | -0.050 | 3 | 0.750 |
NTRK2 |
0.769 | -0.128 | 3 | 0.750 |
MET |
0.768 | -0.133 | 3 | 0.775 |
EPHA7 |
0.768 | -0.070 | 2 | 0.745 |
FRK |
0.768 | -0.061 | -1 | 0.903 |
DDR2 |
0.768 | -0.013 | 3 | 0.730 |
PTK2B |
0.766 | -0.012 | -1 | 0.860 |
NTRK1 |
0.765 | -0.201 | -1 | 0.868 |
FLT1 |
0.765 | -0.132 | -1 | 0.861 |
LYN |
0.764 | -0.064 | 3 | 0.728 |
EPHA3 |
0.764 | -0.139 | 2 | 0.712 |
INSR |
0.764 | -0.155 | 3 | 0.727 |
FYN |
0.763 | -0.046 | -1 | 0.860 |
ERBB2 |
0.763 | -0.185 | 1 | 0.838 |
FLT4 |
0.762 | -0.172 | 3 | 0.744 |
NTRK3 |
0.762 | -0.142 | -1 | 0.825 |
CK1G3 |
0.761 | -0.131 | -3 | 0.314 |
MUSK |
0.761 | -0.055 | 1 | 0.742 |
YANK2 |
0.758 | -0.151 | 2 | 0.399 |
FGFR3 |
0.757 | -0.228 | 3 | 0.758 |
SRC |
0.756 | -0.091 | -1 | 0.862 |
EPHA5 |
0.755 | -0.138 | 2 | 0.707 |
MATK |
0.754 | -0.161 | -1 | 0.786 |
EPHA8 |
0.753 | -0.139 | -1 | 0.853 |
CSK |
0.750 | -0.212 | 2 | 0.753 |
EGFR |
0.750 | -0.141 | 1 | 0.753 |
IGF1R |
0.744 | -0.186 | 3 | 0.674 |
FGFR4 |
0.744 | -0.198 | -1 | 0.824 |
PTK2 |
0.743 | -0.086 | -1 | 0.799 |
EPHA2 |
0.743 | -0.146 | -1 | 0.825 |
SYK |
0.739 | -0.131 | -1 | 0.803 |
ERBB4 |
0.735 | -0.144 | 1 | 0.762 |
CK1G2 |
0.733 | -0.163 | -3 | 0.409 |
FES |
0.731 | -0.174 | -1 | 0.772 |
ZAP70 |
0.714 | -0.152 | -1 | 0.723 |