Motif 97 (n=87)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S1037 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A2RU30 | TESPA1 | S356 | ochoa | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}. |
| A5YKK6 | CNOT1 | S749 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| A6NC98 | CCDC88B | S600 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6NF01 | POM121B | S542 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A6NKT7 | RGPD3 | S919 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A7KAX9 | ARHGAP32 | S952 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A7KAX9 | ARHGAP32 | S1203 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8CG34 | POM121C | S935 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00232 | PSMD12 | S335 | ochoa | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O14715 | RGPD8 | S918 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15075 | DCLK1 | S337 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15169 | AXIN1 | S217 | ochoa|psp | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O43189 | PHF1 | S515 | ochoa | PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) | Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}. |
| O43296 | ZNF264 | S150 | ochoa | Zinc finger protein 264 | May be involved in transcriptional regulation. |
| O43933 | PEX1 | S1172 | ochoa | Peroxisomal ATPase PEX1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis disorder protein 1) (Peroxisome biogenesis factor 1) | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772). {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118, ECO:0000269|PubMed:29884772}. |
| O60941 | DTNB | S555 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75061 | DNAJC6 | S709 | ochoa | Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) | May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}. |
| O75362 | ZNF217 | S980 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| P02671 | FGA | S356 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P10075 | GLI4 | S86 | ochoa | Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4) | None |
| P13378 | HOXD8 | S181 | ochoa | Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P46108 | CRK | S74 | ochoa | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P48552 | NRIP1 | S356 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P48637 | GSS | S415 | ochoa | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
| P49792 | RANBP2 | S1894 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P56945 | BCAR1 | S648 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| Q09666 | AHNAK | S5321 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13507 | TRPC3 | S785 | psp | Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:29726814, PubMed:30139744, PubMed:35051376, PubMed:9417057, PubMed:9930701, PubMed:10611319). {ECO:0000269|PubMed:10611319, ECO:0000269|PubMed:29726814, ECO:0000269|PubMed:30139744, ECO:0000269|PubMed:35051376, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.; FUNCTION: [Isoform 2]: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. {ECO:0000269|PubMed:8646775}. |
| Q13796 | SHROOM2 | S1039 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14524 | SCN5A | S577 | ochoa | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14789 | GOLGB1 | S3010 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15911 | ZFHX3 | S426 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q2KHR3 | QSER1 | S236 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2TAL5 | SMTNL2 | S281 | ochoa | Smoothelin-like protein 2 | None |
| Q3KR37 | GRAMD1B | S30 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q4ZG55 | GREB1 | S320 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
| Q53TQ3 | INO80D | S232 | ochoa | INO80 complex subunit D | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q5JTC6 | AMER1 | S518 | psp | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5T6F2 | UBAP2 | S633 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q5VT97 | SYDE2 | S1082 | ochoa | Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q68D10 | SPTY2D1 | S365 | ochoa | Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) | Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). {ECO:0000250|UniProtKB:E1BUG7, ECO:0000269|PubMed:23378026}. |
| Q69YH5 | CDCA2 | S960 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6P1L5 | FAM117B | S391 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6V0I7 | FAT4 | S4702 | ochoa | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}. |
| Q6ZNC4 | ZNF704 | S346 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q7Z2D5 | PLPPR4 | S547 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z2K8 | GPRIN1 | S64 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3J3 | RGPD4 | S919 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z591 | AKNA | S316 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q86VM9 | ZC3H18 | S791 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86Y07 | VRK2 | S438 | ochoa | Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) | Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249, PubMed:16495336, PubMed:16704422, PubMed:17709393, PubMed:18286207, PubMed:18617507, PubMed:20679487). Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (PubMed:17709393). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (PubMed:18286207). Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 (PubMed:16704422). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (PubMed:16495336). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (PubMed:20679487). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (PubMed:20679487). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (PubMed:14645249). {ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:17709393, ECO:0000269|PubMed:18286207, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20679487}.; FUNCTION: [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. {ECO:0000269|PubMed:16704422}. |
| Q8IUG5 | MYO18B | S1216 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IYT8 | ULK2 | S771 | ochoa | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. |
| Q8N1I0 | DOCK4 | S1799 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N264 | ARHGAP24 | S415 | ochoa|psp | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Q8N3V7 | SYNPO | S235 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N8K9 | KIAA1958 | S291 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NDV7 | TNRC6A | S1944 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8WWL2 | SPIRE2 | S476 | ochoa | Protein spire homolog 2 (Spir-2) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q8K1S6, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480}. |
| Q93052 | LPP | S231 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q969S8 | HDAC10 | S373 | ochoa | Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}. |
| Q96AY4 | TTC28 | S2293 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96HA1 | POM121 | S958 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96JK9 | MAML3 | S373 | ochoa | Mastermind-like protein 3 (Mam-3) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158}. |
| Q96JM2 | ZNF462 | S350 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96PN7 | TRERF1 | S491 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96T17 | MAP7D2 | S186 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q99666 | RGPD5 | S918 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BWF2 | TRAIP | S347 | ochoa | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) | E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). {ECO:0000250|UniProtKB:Q6NRV0, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:31545170}. |
| Q9C0A6 | SETD5 | S865 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0G0 | ZNF407 | S426 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9HAW4 | CLSPN | S1316 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9NX95 | SYBU | S99 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9NZT2 | OGFR | S315 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9ULD9 | ZNF608 | S627 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULM3 | YEATS2 | S868 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UPQ9 | TNRC6B | S1816 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UQ35 | SRRM2 | S1320 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2664 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2I7 | PIKFYVE | S88 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y4J8 | DTNA | S584 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y4K4 | MAP4K5 | Y401 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
| Q9Y534 | CSDC2 | S19 | ochoa | Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}. |
| Q9Y6Q9 | NCOA3 | S917 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q13409 | DYNC1I2 | T95 | Sugiyama | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}. |
| Q8N264 | ARHGAP24 | S573 | SIGNOR|iPTMNet|EPSD | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.912475e-08 | 7.718 |
| R-HSA-8939211 | ESR-mediated signaling | 2.122361e-06 | 5.673 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.434069e-05 | 4.614 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.630584e-05 | 4.440 |
| R-HSA-4839735 | Signaling by AXIN mutants | 9.234663e-05 | 4.035 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 9.234663e-05 | 4.035 |
| R-HSA-4791275 | Signaling by WNT in cancer | 7.035588e-05 | 4.153 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 8.772624e-05 | 4.057 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.429501e-05 | 4.192 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.831441e-04 | 3.548 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.363983e-04 | 3.271 |
| R-HSA-211000 | Gene Silencing by RNA | 6.050341e-04 | 3.218 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.171903e-03 | 2.931 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.267139e-03 | 2.897 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.267139e-03 | 2.897 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.471919e-03 | 2.832 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.471919e-03 | 2.832 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.581635e-03 | 2.801 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 7.541387e-04 | 3.123 |
| R-HSA-354192 | Integrin signaling | 1.471919e-03 | 2.832 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.154291e-03 | 2.938 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 1.237515e-03 | 2.907 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.581635e-03 | 2.801 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.522199e-03 | 2.818 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.173159e-04 | 3.037 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.835117e-03 | 2.736 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.816133e-03 | 2.741 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.347608e-03 | 2.629 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.071253e-03 | 2.684 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.696346e-03 | 2.770 |
| R-HSA-195721 | Signaling by WNT | 2.233620e-03 | 2.651 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.206739e-03 | 2.656 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.347608e-03 | 2.629 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.994231e-03 | 2.700 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.493933e-03 | 2.603 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.493933e-03 | 2.603 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.493933e-03 | 2.603 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.645784e-03 | 2.577 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.940077e-03 | 2.532 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.940077e-03 | 2.532 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.940077e-03 | 2.532 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.940077e-03 | 2.532 |
| R-HSA-4839744 | Signaling by APC mutants | 2.940077e-03 | 2.532 |
| R-HSA-74160 | Gene expression (Transcription) | 3.236383e-03 | 2.490 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 3.362751e-03 | 2.473 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 3.812082e-03 | 2.419 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 3.812082e-03 | 2.419 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 3.812082e-03 | 2.419 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 3.812082e-03 | 2.419 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 3.812082e-03 | 2.419 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.490296e-03 | 2.457 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.490296e-03 | 2.457 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.676699e-03 | 2.435 |
| R-HSA-162582 | Signal Transduction | 4.559192e-03 | 2.341 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 5.316967e-03 | 2.274 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 5.316967e-03 | 2.274 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 4.789494e-03 | 2.320 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.801077e-03 | 2.319 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.801077e-03 | 2.319 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 5.635358e-03 | 2.249 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 5.635358e-03 | 2.249 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.663271e-03 | 2.176 |
| R-HSA-191859 | snRNP Assembly | 6.663271e-03 | 2.176 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.219498e-03 | 2.141 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 7.050870e-03 | 2.152 |
| R-HSA-68875 | Mitotic Prophase | 7.219900e-03 | 2.141 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.507630e-03 | 2.124 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.645037e-03 | 2.117 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.984838e-03 | 2.098 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 9.005835e-03 | 2.045 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 9.705269e-03 | 2.013 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.117411e-02 | 1.952 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.112838e-02 | 1.954 |
| R-HSA-68882 | Mitotic Anaphase | 1.111716e-02 | 1.954 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.130537e-02 | 1.947 |
| R-HSA-418990 | Adherens junctions interactions | 1.149575e-02 | 1.939 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.187736e-02 | 1.925 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 1.194295e-02 | 1.923 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.265474e-02 | 1.898 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.309822e-02 | 1.883 |
| R-HSA-9839394 | TGFBR3 expression | 1.354812e-02 | 1.868 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.438390e-02 | 1.842 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.472343e-02 | 1.832 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.524145e-02 | 1.817 |
| R-HSA-157118 | Signaling by NOTCH | 1.625492e-02 | 1.789 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.940371e-02 | 1.712 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 1.888406e-02 | 1.724 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.082918e-02 | 1.681 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.702080e-02 | 1.769 |
| R-HSA-186763 | Downstream signal transduction | 1.888406e-02 | 1.724 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.082918e-02 | 1.681 |
| R-HSA-421270 | Cell-cell junction organization | 1.906505e-02 | 1.720 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.367399e-02 | 1.626 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.389588e-02 | 1.622 |
| R-HSA-70171 | Glycolysis | 2.539627e-02 | 1.595 |
| R-HSA-4641257 | Degradation of AXIN | 2.603680e-02 | 1.584 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.658107e-02 | 1.575 |
| R-HSA-68886 | M Phase | 2.698573e-02 | 1.569 |
| R-HSA-446728 | Cell junction organization | 2.727195e-02 | 1.564 |
| R-HSA-5579006 | Defective GSS causes GSS deficiency | 2.786441e-02 | 1.555 |
| R-HSA-212436 | Generic Transcription Pathway | 3.033326e-02 | 1.518 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.054139e-02 | 1.515 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.361896e-02 | 1.473 |
| R-HSA-9609690 | HCMV Early Events | 3.402075e-02 | 1.468 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.430230e-02 | 1.465 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.782690e-02 | 1.422 |
| R-HSA-70326 | Glucose metabolism | 3.855319e-02 | 1.414 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.169421e-02 | 1.380 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 4.421301e-02 | 1.354 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.707020e-02 | 1.327 |
| R-HSA-1500931 | Cell-Cell communication | 4.218827e-02 | 1.375 |
| R-HSA-162906 | HIV Infection | 5.186191e-02 | 1.285 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.570332e-02 | 1.340 |
| R-HSA-3371556 | Cellular response to heat stress | 4.152975e-02 | 1.382 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.412407e-02 | 1.267 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 5.496070e-02 | 1.260 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.630268e-02 | 1.249 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.704425e-02 | 1.244 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.704425e-02 | 1.244 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.704425e-02 | 1.244 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.704425e-02 | 1.244 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.704425e-02 | 1.244 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.741949e-02 | 1.241 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.749076e-02 | 1.240 |
| R-HSA-8875656 | MET receptor recycling | 6.028963e-02 | 1.220 |
| R-HSA-170984 | ARMS-mediated activation | 6.558885e-02 | 1.183 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 7.085850e-02 | 1.150 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 8.649176e-02 | 1.063 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 8.649176e-02 | 1.063 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.891171e-02 | 1.103 |
| R-HSA-6807070 | PTEN Regulation | 5.897843e-02 | 1.229 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.456917e-02 | 1.073 |
| R-HSA-1980143 | Signaling by NOTCH1 | 8.222173e-02 | 1.085 |
| R-HSA-5689603 | UCH proteinases | 8.222173e-02 | 1.085 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 8.649176e-02 | 1.063 |
| R-HSA-9609646 | HCMV Infection | 6.731284e-02 | 1.172 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.564537e-02 | 1.121 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.523855e-02 | 1.124 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.319137e-02 | 1.136 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.570684e-02 | 1.067 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 8.056135e-02 | 1.094 |
| R-HSA-9610379 | HCMV Late Events | 7.727017e-02 | 1.112 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.852467e-02 | 1.233 |
| R-HSA-5688426 | Deubiquitination | 7.095689e-02 | 1.149 |
| R-HSA-8848021 | Signaling by PTK6 | 6.152523e-02 | 1.211 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.152523e-02 | 1.211 |
| R-HSA-4086398 | Ca2+ pathway | 7.727300e-02 | 1.112 |
| R-HSA-186797 | Signaling by PDGF | 6.001840e-02 | 1.222 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.263816e-02 | 1.203 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.924930e-02 | 1.160 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.263816e-02 | 1.203 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.517478e-02 | 1.186 |
| R-HSA-162587 | HIV Life Cycle | 7.727017e-02 | 1.112 |
| R-HSA-5619102 | SLC transporter disorders | 8.778508e-02 | 1.057 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.423187e-02 | 1.129 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 8.896732e-02 | 1.051 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.982054e-02 | 1.047 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 9.164481e-02 | 1.038 |
| R-HSA-72306 | tRNA processing | 9.215271e-02 | 1.035 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.437010e-02 | 1.025 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.548707e-02 | 1.020 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.937983e-02 | 1.003 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.937983e-02 | 1.003 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 1.018648e-01 | 0.992 |
| R-HSA-168255 | Influenza Infection | 1.023026e-01 | 0.990 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.065027e-01 | 0.973 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.069321e-01 | 0.971 |
| R-HSA-169893 | Prolonged ERK activation events | 1.069321e-01 | 0.971 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.069321e-01 | 0.971 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.069519e-01 | 0.971 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.367474e-01 | 0.864 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.416199e-01 | 0.849 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.842669e-01 | 0.735 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.367474e-01 | 0.864 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.204120e-01 | 0.657 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.655778e-01 | 0.781 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.305269e-01 | 0.884 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 1.749747e-01 | 0.757 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.888741e-01 | 0.724 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.159819e-01 | 0.666 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.169820e-01 | 0.932 |
| R-HSA-1980145 | Signaling by NOTCH2 | 2.070471e-01 | 0.684 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.299105e-01 | 0.886 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.934556e-01 | 0.713 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.115270e-01 | 0.675 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.115270e-01 | 0.675 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.230035e-01 | 0.910 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.775802e-01 | 0.751 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.655778e-01 | 0.781 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.269200e-01 | 0.896 |
| R-HSA-4641258 | Degradation of DVL | 2.204120e-01 | 0.657 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.275981e-01 | 0.894 |
| R-HSA-429947 | Deadenylation of mRNA | 1.560751e-01 | 0.807 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.702894e-01 | 0.769 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.159819e-01 | 0.666 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.159819e-01 | 0.666 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.204120e-01 | 0.657 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.842669e-01 | 0.735 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.980115e-01 | 0.703 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.159819e-01 | 0.666 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.169820e-01 | 0.932 |
| R-HSA-9930044 | Nuclear RNA decay | 1.980115e-01 | 0.703 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.025420e-01 | 0.693 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.025420e-01 | 0.693 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.070471e-01 | 0.684 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.070471e-01 | 0.684 |
| R-HSA-169911 | Regulation of Apoptosis | 2.115270e-01 | 0.675 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.497740e-01 | 0.825 |
| R-HSA-187687 | Signalling to ERKs | 2.115270e-01 | 0.675 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.655778e-01 | 0.781 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.052984e-01 | 0.688 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.608398e-01 | 0.794 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.416199e-01 | 0.849 |
| R-HSA-3295583 | TRP channels | 1.655778e-01 | 0.781 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 1.318474e-01 | 0.880 |
| R-HSA-8953854 | Metabolism of RNA | 2.098698e-01 | 0.678 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.796338e-01 | 0.746 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.159819e-01 | 0.666 |
| R-HSA-69481 | G2/M Checkpoints | 1.917738e-01 | 0.717 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.478236e-01 | 0.830 |
| R-HSA-9909396 | Circadian clock | 2.040577e-01 | 0.690 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.153791e-01 | 0.938 |
| R-HSA-174403 | Glutathione synthesis and recycling | 1.416199e-01 | 0.849 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.025420e-01 | 0.693 |
| R-HSA-1640170 | Cell Cycle | 1.186621e-01 | 0.926 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 2.070471e-01 | 0.684 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.343282e-01 | 0.872 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.464653e-01 | 0.834 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.025420e-01 | 0.693 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.115270e-01 | 0.675 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 2.159819e-01 | 0.666 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.655572e-01 | 0.781 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.635679e-01 | 0.786 |
| R-HSA-194138 | Signaling by VEGF | 1.877020e-01 | 0.727 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.657256e-01 | 0.781 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.934556e-01 | 0.713 |
| R-HSA-2262752 | Cellular responses to stress | 1.326859e-01 | 0.877 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.125451e-01 | 0.673 |
| R-HSA-8875878 | MET promotes cell motility | 2.248172e-01 | 0.648 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.291979e-01 | 0.640 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.291979e-01 | 0.640 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.291979e-01 | 0.640 |
| R-HSA-69541 | Stabilization of p53 | 2.291979e-01 | 0.640 |
| R-HSA-9646399 | Aggrephagy | 2.335540e-01 | 0.632 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.335540e-01 | 0.632 |
| R-HSA-5260271 | Diseases of Immune System | 2.335540e-01 | 0.632 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.335540e-01 | 0.632 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.335540e-01 | 0.632 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.378858e-01 | 0.624 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.378858e-01 | 0.624 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.378858e-01 | 0.624 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.378858e-01 | 0.624 |
| R-HSA-597592 | Post-translational protein modification | 2.381927e-01 | 0.623 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.392734e-01 | 0.621 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.421934e-01 | 0.616 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.421934e-01 | 0.616 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.421934e-01 | 0.616 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.421934e-01 | 0.616 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.421934e-01 | 0.616 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.421934e-01 | 0.616 |
| R-HSA-9758941 | Gastrulation | 2.434429e-01 | 0.614 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.455290e-01 | 0.610 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.464769e-01 | 0.608 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.476158e-01 | 0.606 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.507365e-01 | 0.601 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.538801e-01 | 0.595 |
| R-HSA-9907900 | Proteasome assembly | 2.549722e-01 | 0.594 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.549722e-01 | 0.594 |
| R-HSA-373752 | Netrin-1 signaling | 2.549722e-01 | 0.594 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.591843e-01 | 0.586 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.591843e-01 | 0.586 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.591843e-01 | 0.586 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.591843e-01 | 0.586 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.591843e-01 | 0.586 |
| R-HSA-9824272 | Somitogenesis | 2.591843e-01 | 0.586 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.633728e-01 | 0.579 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.633728e-01 | 0.579 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.633728e-01 | 0.579 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.633728e-01 | 0.579 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.633728e-01 | 0.579 |
| R-HSA-75153 | Apoptotic execution phase | 2.633728e-01 | 0.579 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.634640e-01 | 0.579 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.664197e-01 | 0.574 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.675379e-01 | 0.573 |
| R-HSA-109581 | Apoptosis | 2.706008e-01 | 0.568 |
| R-HSA-9766229 | Degradation of CDH1 | 2.757983e-01 | 0.559 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.757983e-01 | 0.559 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.757983e-01 | 0.559 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.798939e-01 | 0.553 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.839666e-01 | 0.547 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.839666e-01 | 0.547 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.839666e-01 | 0.547 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.880165e-01 | 0.541 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.880165e-01 | 0.541 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.880165e-01 | 0.541 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.920437e-01 | 0.535 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.920437e-01 | 0.535 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.920437e-01 | 0.535 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.960484e-01 | 0.529 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.000307e-01 | 0.523 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.000307e-01 | 0.523 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.000307e-01 | 0.523 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.000307e-01 | 0.523 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.039908e-01 | 0.517 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.079286e-01 | 0.512 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.079286e-01 | 0.512 |
| R-HSA-2559583 | Cellular Senescence | 3.102371e-01 | 0.508 |
| R-HSA-9033241 | Peroxisomal protein import | 3.157384e-01 | 0.501 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.157384e-01 | 0.501 |
| R-HSA-186712 | Regulation of beta-cell development | 3.157384e-01 | 0.501 |
| R-HSA-1474244 | Extracellular matrix organization | 3.188090e-01 | 0.496 |
| R-HSA-156590 | Glutathione conjugation | 3.196105e-01 | 0.495 |
| R-HSA-351202 | Metabolism of polyamines | 3.196105e-01 | 0.495 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.196105e-01 | 0.495 |
| R-HSA-69275 | G2/M Transition | 3.226831e-01 | 0.491 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.234610e-01 | 0.490 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.268203e-01 | 0.486 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.272899e-01 | 0.485 |
| R-HSA-9707616 | Heme signaling | 3.272899e-01 | 0.485 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.272899e-01 | 0.485 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.310973e-01 | 0.480 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.310973e-01 | 0.480 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.310973e-01 | 0.480 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.358226e-01 | 0.474 |
| R-HSA-68877 | Mitotic Prometaphase | 3.371348e-01 | 0.472 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.386484e-01 | 0.470 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.386484e-01 | 0.470 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.423923e-01 | 0.465 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.466452e-01 | 0.460 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.498173e-01 | 0.456 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.555828e-01 | 0.449 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.571594e-01 | 0.447 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.571594e-01 | 0.447 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.571594e-01 | 0.447 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.571594e-01 | 0.447 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.607996e-01 | 0.443 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.607996e-01 | 0.443 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.607996e-01 | 0.443 |
| R-HSA-5357801 | Programmed Cell Death | 3.637264e-01 | 0.439 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.644194e-01 | 0.438 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.644194e-01 | 0.438 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.680190e-01 | 0.434 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.680190e-01 | 0.434 |
| R-HSA-380287 | Centrosome maturation | 3.751577e-01 | 0.426 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.798982e-01 | 0.420 |
| R-HSA-216083 | Integrin cell surface interactions | 3.857165e-01 | 0.414 |
| R-HSA-5619084 | ABC transporter disorders | 3.857165e-01 | 0.414 |
| R-HSA-4086400 | PCP/CE pathway | 3.857165e-01 | 0.414 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 3.891968e-01 | 0.410 |
| R-HSA-6806834 | Signaling by MET | 3.926575e-01 | 0.406 |
| R-HSA-8951664 | Neddylation | 3.959007e-01 | 0.402 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.960989e-01 | 0.402 |
| R-HSA-977225 | Amyloid fiber formation | 3.960989e-01 | 0.402 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.004109e-01 | 0.397 |
| R-HSA-913531 | Interferon Signaling | 4.004109e-01 | 0.397 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.029238e-01 | 0.395 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.063076e-01 | 0.391 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.063076e-01 | 0.391 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.063076e-01 | 0.391 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.096725e-01 | 0.388 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.130184e-01 | 0.384 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.215017e-01 | 0.375 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.229442e-01 | 0.374 |
| R-HSA-9663891 | Selective autophagy | 4.229442e-01 | 0.374 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.294690e-01 | 0.367 |
| R-HSA-202424 | Downstream TCR signaling | 4.294690e-01 | 0.367 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.423005e-01 | 0.354 |
| R-HSA-4839726 | Chromatin organization | 4.503520e-01 | 0.346 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.517364e-01 | 0.345 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.548465e-01 | 0.342 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 4.548465e-01 | 0.342 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.610144e-01 | 0.336 |
| R-HSA-3214847 | HATs acetylate histones | 4.640724e-01 | 0.333 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.671132e-01 | 0.331 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.671132e-01 | 0.331 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.701370e-01 | 0.328 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.731439e-01 | 0.325 |
| R-HSA-1483255 | PI Metabolism | 4.731439e-01 | 0.325 |
| R-HSA-109582 | Hemostasis | 4.798517e-01 | 0.319 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.820634e-01 | 0.317 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.820634e-01 | 0.317 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.850033e-01 | 0.314 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.857236e-01 | 0.314 |
| R-HSA-418346 | Platelet homeostasis | 4.879267e-01 | 0.312 |
| R-HSA-69239 | Synthesis of DNA | 4.908337e-01 | 0.309 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.908337e-01 | 0.309 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.908337e-01 | 0.309 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.937243e-01 | 0.307 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.965987e-01 | 0.304 |
| R-HSA-202403 | TCR signaling | 4.994570e-01 | 0.302 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 5.064490e-01 | 0.295 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.107304e-01 | 0.292 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.108852e-01 | 0.292 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.135093e-01 | 0.289 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.204522e-01 | 0.284 |
| R-HSA-373760 | L1CAM interactions | 5.217526e-01 | 0.283 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.231663e-01 | 0.281 |
| R-HSA-5693538 | Homology Directed Repair | 5.271713e-01 | 0.278 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.298578e-01 | 0.276 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.298578e-01 | 0.276 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.298578e-01 | 0.276 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.351857e-01 | 0.271 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.352428e-01 | 0.271 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.378271e-01 | 0.269 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.378271e-01 | 0.269 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.404538e-01 | 0.267 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.404538e-01 | 0.267 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.482454e-01 | 0.261 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.482454e-01 | 0.261 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.482454e-01 | 0.261 |
| R-HSA-69206 | G1/S Transition | 5.482454e-01 | 0.261 |
| R-HSA-114608 | Platelet degranulation | 5.533671e-01 | 0.257 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.559064e-01 | 0.255 |
| R-HSA-1280218 | Adaptive Immune System | 5.647507e-01 | 0.248 |
| R-HSA-9843745 | Adipogenesis | 5.659214e-01 | 0.247 |
| R-HSA-5576891 | Cardiac conduction | 5.659214e-01 | 0.247 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.683901e-01 | 0.245 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.708449e-01 | 0.243 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.852862e-01 | 0.233 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.852862e-01 | 0.233 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.899923e-01 | 0.229 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.899923e-01 | 0.229 |
| R-HSA-9664407 | Parasite infection | 5.899923e-01 | 0.229 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.923256e-01 | 0.227 |
| R-HSA-1632852 | Macroautophagy | 5.923256e-01 | 0.227 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.992467e-01 | 0.222 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.015279e-01 | 0.221 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.060517e-01 | 0.217 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.105247e-01 | 0.214 |
| R-HSA-69242 | S Phase | 6.105247e-01 | 0.214 |
| R-HSA-166520 | Signaling by NTRKs | 6.105247e-01 | 0.214 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.193205e-01 | 0.208 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.193205e-01 | 0.208 |
| R-HSA-9609507 | Protein localization | 6.214886e-01 | 0.207 |
| R-HSA-69306 | DNA Replication | 6.214886e-01 | 0.207 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.214886e-01 | 0.207 |
| R-HSA-422475 | Axon guidance | 6.242710e-01 | 0.205 |
| R-HSA-1989781 | PPARA activates gene expression | 6.257882e-01 | 0.204 |
| R-HSA-9612973 | Autophagy | 6.279199e-01 | 0.202 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.300395e-01 | 0.201 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.321472e-01 | 0.199 |
| R-HSA-73894 | DNA Repair | 6.358645e-01 | 0.197 |
| R-HSA-9679506 | SARS-CoV Infections | 6.361397e-01 | 0.196 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.604376e-01 | 0.180 |
| R-HSA-1643685 | Disease | 6.636798e-01 | 0.178 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.662139e-01 | 0.176 |
| R-HSA-9675108 | Nervous system development | 6.668941e-01 | 0.176 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.681177e-01 | 0.175 |
| R-HSA-983712 | Ion channel transport | 6.936695e-01 | 0.159 |
| R-HSA-5617833 | Cilium Assembly | 6.954183e-01 | 0.158 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.971572e-01 | 0.157 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.023153e-01 | 0.153 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.123723e-01 | 0.147 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.172740e-01 | 0.144 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.172740e-01 | 0.144 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.176950e-01 | 0.144 |
| R-HSA-72172 | mRNA Splicing | 7.204958e-01 | 0.142 |
| R-HSA-397014 | Muscle contraction | 7.330239e-01 | 0.135 |
| R-HSA-199991 | Membrane Trafficking | 7.341004e-01 | 0.134 |
| R-HSA-392499 | Metabolism of proteins | 7.367950e-01 | 0.133 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.489676e-01 | 0.126 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 7.713445e-01 | 0.113 |
| R-HSA-9824446 | Viral Infection Pathways | 7.852114e-01 | 0.105 |
| R-HSA-416476 | G alpha (q) signalling events | 8.019507e-01 | 0.096 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.204113e-01 | 0.086 |
| R-HSA-9658195 | Leishmania infection | 8.204113e-01 | 0.086 |
| R-HSA-1483257 | Phospholipid metabolism | 8.343278e-01 | 0.079 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.532735e-01 | 0.069 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.565768e-01 | 0.067 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.777145e-01 | 0.057 |
| R-HSA-1266738 | Developmental Biology | 8.806410e-01 | 0.055 |
| R-HSA-449147 | Signaling by Interleukins | 8.842807e-01 | 0.053 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.070752e-01 | 0.042 |
| R-HSA-5668914 | Diseases of metabolism | 9.232795e-01 | 0.035 |
| R-HSA-72766 | Translation | 9.241663e-01 | 0.034 |
| R-HSA-5663205 | Infectious disease | 9.307322e-01 | 0.031 |
| R-HSA-6798695 | Neutrophil degranulation | 9.355676e-01 | 0.029 |
| R-HSA-211859 | Biological oxidations | 9.561656e-01 | 0.019 |
| R-HSA-372790 | Signaling by GPCR | 9.619877e-01 | 0.017 |
| R-HSA-168256 | Immune System | 9.654787e-01 | 0.015 |
| R-HSA-500792 | GPCR ligand binding | 9.702276e-01 | 0.013 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.748945e-01 | 0.011 |
| R-HSA-382551 | Transport of small molecules | 9.796549e-01 | 0.009 |
| R-HSA-168249 | Innate Immune System | 9.848907e-01 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 9.900216e-01 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 9.986549e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999794e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.836 | 0.771 | 1 | 0.856 |
CDK18 |
0.830 | 0.804 | 1 | 0.878 |
CDK19 |
0.830 | 0.812 | 1 | 0.865 |
KIS |
0.826 | 0.721 | 1 | 0.835 |
CDK8 |
0.825 | 0.807 | 1 | 0.841 |
CDK17 |
0.823 | 0.797 | 1 | 0.893 |
P38G |
0.822 | 0.810 | 1 | 0.904 |
P38B |
0.822 | 0.832 | 1 | 0.890 |
ERK1 |
0.822 | 0.815 | 1 | 0.893 |
CDK1 |
0.820 | 0.768 | 1 | 0.873 |
CDK7 |
0.819 | 0.776 | 1 | 0.849 |
JNK2 |
0.817 | 0.807 | 1 | 0.885 |
DYRK2 |
0.817 | 0.735 | 1 | 0.811 |
P38D |
0.816 | 0.799 | 1 | 0.902 |
CDK16 |
0.816 | 0.765 | 1 | 0.882 |
CDK3 |
0.814 | 0.688 | 1 | 0.893 |
HIPK4 |
0.813 | 0.577 | 1 | 0.626 |
DYRK4 |
0.812 | 0.722 | 1 | 0.874 |
P38A |
0.812 | 0.814 | 1 | 0.836 |
CDK5 |
0.812 | 0.743 | 1 | 0.832 |
CLK3 |
0.810 | 0.512 | 1 | 0.620 |
CDK10 |
0.809 | 0.716 | 1 | 0.863 |
CDK13 |
0.808 | 0.746 | 1 | 0.861 |
HIPK1 |
0.808 | 0.680 | 1 | 0.790 |
CDK12 |
0.807 | 0.748 | 1 | 0.876 |
JNK3 |
0.805 | 0.781 | 1 | 0.865 |
DYRK1B |
0.804 | 0.692 | 1 | 0.845 |
CDK9 |
0.802 | 0.730 | 1 | 0.858 |
MAK |
0.802 | 0.616 | -2 | 0.830 |
DYRK1A |
0.802 | 0.637 | 1 | 0.775 |
CDK14 |
0.800 | 0.740 | 1 | 0.850 |
ERK2 |
0.800 | 0.772 | 1 | 0.851 |
HIPK3 |
0.796 | 0.660 | 1 | 0.771 |
SRPK1 |
0.794 | 0.353 | -3 | 0.687 |
ICK |
0.791 | 0.493 | -3 | 0.740 |
CDK4 |
0.790 | 0.735 | 1 | 0.873 |
NLK |
0.790 | 0.661 | 1 | 0.650 |
CLK2 |
0.789 | 0.396 | -3 | 0.675 |
CDKL5 |
0.789 | 0.312 | -3 | 0.711 |
CDK6 |
0.789 | 0.709 | 1 | 0.858 |
ERK5 |
0.788 | 0.438 | 1 | 0.631 |
JNK1 |
0.787 | 0.697 | 1 | 0.876 |
SRPK2 |
0.786 | 0.295 | -3 | 0.617 |
DYRK3 |
0.786 | 0.524 | 1 | 0.757 |
CLK1 |
0.784 | 0.398 | -3 | 0.677 |
MOK |
0.783 | 0.541 | 1 | 0.725 |
CDK2 |
0.781 | 0.557 | 1 | 0.784 |
MTOR |
0.779 | 0.270 | 1 | 0.457 |
CLK4 |
0.779 | 0.359 | -3 | 0.695 |
CDKL1 |
0.778 | 0.255 | -3 | 0.715 |
SRPK3 |
0.772 | 0.254 | -3 | 0.658 |
NDR2 |
0.771 | 0.075 | -3 | 0.711 |
COT |
0.771 | -0.038 | 2 | 0.811 |
CDC7 |
0.767 | -0.007 | 1 | 0.328 |
PRP4 |
0.765 | 0.439 | -3 | 0.678 |
PRKD1 |
0.764 | 0.056 | -3 | 0.709 |
PIM3 |
0.763 | 0.017 | -3 | 0.726 |
MOS |
0.763 | 0.045 | 1 | 0.354 |
ATR |
0.759 | 0.019 | 1 | 0.376 |
PRKD2 |
0.759 | 0.050 | -3 | 0.680 |
PIM1 |
0.758 | 0.063 | -3 | 0.703 |
CHAK2 |
0.757 | 0.033 | -1 | 0.843 |
TBK1 |
0.757 | -0.091 | 1 | 0.260 |
PRPK |
0.756 | -0.063 | -1 | 0.782 |
CAMK1B |
0.756 | -0.006 | -3 | 0.760 |
NDR1 |
0.755 | -0.012 | -3 | 0.717 |
MST4 |
0.755 | -0.003 | 2 | 0.811 |
LATS2 |
0.755 | 0.021 | -5 | 0.749 |
RAF1 |
0.754 | -0.134 | 1 | 0.299 |
WNK1 |
0.754 | -0.025 | -2 | 0.716 |
NUAK2 |
0.754 | 0.023 | -3 | 0.745 |
GCN2 |
0.753 | -0.157 | 2 | 0.723 |
GRK1 |
0.753 | 0.031 | -2 | 0.678 |
CK1E |
0.752 | 0.141 | -3 | 0.642 |
MPSK1 |
0.752 | 0.206 | 1 | 0.334 |
ERK7 |
0.751 | 0.233 | 2 | 0.452 |
AURC |
0.751 | 0.016 | -2 | 0.476 |
RSK2 |
0.750 | 0.004 | -3 | 0.693 |
PKN3 |
0.750 | -0.038 | -3 | 0.712 |
IKKB |
0.749 | -0.162 | -2 | 0.589 |
IKKE |
0.749 | -0.147 | 1 | 0.255 |
NIK |
0.748 | -0.031 | -3 | 0.758 |
MAPKAPK2 |
0.748 | 0.008 | -3 | 0.640 |
SKMLCK |
0.748 | -0.037 | -2 | 0.692 |
P90RSK |
0.748 | 0.007 | -3 | 0.687 |
AMPKA1 |
0.747 | -0.030 | -3 | 0.740 |
PDHK4 |
0.747 | -0.160 | 1 | 0.360 |
PKCD |
0.747 | -0.010 | 2 | 0.722 |
BMPR2 |
0.747 | -0.160 | -2 | 0.709 |
MAPKAPK3 |
0.747 | -0.018 | -3 | 0.671 |
CAMK2D |
0.747 | -0.048 | -3 | 0.731 |
NEK6 |
0.746 | -0.094 | -2 | 0.661 |
PKN2 |
0.746 | -0.055 | -3 | 0.740 |
AMPKA2 |
0.746 | -0.007 | -3 | 0.716 |
DSTYK |
0.746 | -0.174 | 2 | 0.805 |
RSK3 |
0.745 | -0.012 | -3 | 0.671 |
RIPK3 |
0.745 | -0.096 | 3 | 0.689 |
TGFBR2 |
0.745 | -0.093 | -2 | 0.632 |
CAMK2G |
0.745 | -0.087 | 2 | 0.777 |
GRK7 |
0.745 | 0.035 | 1 | 0.332 |
DAPK2 |
0.744 | -0.028 | -3 | 0.757 |
ULK2 |
0.744 | -0.205 | 2 | 0.696 |
MLK2 |
0.744 | -0.036 | 2 | 0.747 |
IRE1 |
0.744 | -0.047 | 1 | 0.289 |
PKACG |
0.743 | -0.031 | -2 | 0.532 |
IKKA |
0.743 | -0.095 | -2 | 0.603 |
P70S6KB |
0.743 | -0.009 | -3 | 0.703 |
CAMLCK |
0.743 | -0.034 | -2 | 0.660 |
PRKD3 |
0.742 | 0.018 | -3 | 0.665 |
BMPR1B |
0.742 | -0.020 | 1 | 0.306 |
MARK4 |
0.742 | -0.069 | 4 | 0.800 |
CK1D |
0.742 | 0.141 | -3 | 0.608 |
TSSK1 |
0.742 | -0.020 | -3 | 0.753 |
PKCB |
0.742 | -0.012 | 2 | 0.665 |
GRK5 |
0.741 | -0.105 | -3 | 0.749 |
CAMK2A |
0.741 | 0.013 | 2 | 0.776 |
PDHK1 |
0.741 | -0.185 | 1 | 0.328 |
MLK1 |
0.741 | -0.109 | 2 | 0.736 |
PKACB |
0.741 | 0.011 | -2 | 0.472 |
HUNK |
0.741 | -0.151 | 2 | 0.716 |
RSK4 |
0.741 | 0.021 | -3 | 0.658 |
LATS1 |
0.740 | 0.026 | -3 | 0.709 |
PRKX |
0.740 | 0.036 | -3 | 0.615 |
PKCG |
0.740 | -0.014 | 2 | 0.666 |
PKCA |
0.740 | -0.002 | 2 | 0.653 |
NUAK1 |
0.740 | -0.019 | -3 | 0.681 |
DLK |
0.739 | -0.116 | 1 | 0.319 |
NEK7 |
0.739 | -0.199 | -3 | 0.698 |
PHKG1 |
0.739 | -0.044 | -3 | 0.721 |
PKCZ |
0.739 | -0.016 | 2 | 0.687 |
MLK3 |
0.739 | -0.029 | 2 | 0.678 |
AKT2 |
0.738 | 0.030 | -3 | 0.636 |
MNK2 |
0.738 | -0.032 | -2 | 0.591 |
BCKDK |
0.737 | -0.138 | -1 | 0.746 |
GSK3A |
0.737 | 0.196 | 4 | 0.421 |
DNAPK |
0.737 | -0.010 | 1 | 0.342 |
ULK1 |
0.736 | -0.185 | -3 | 0.666 |
PAK1 |
0.736 | -0.045 | -2 | 0.619 |
MASTL |
0.736 | -0.167 | -2 | 0.645 |
RIPK1 |
0.736 | -0.149 | 1 | 0.296 |
CAMK2B |
0.736 | -0.036 | 2 | 0.761 |
ALK4 |
0.735 | -0.051 | -2 | 0.679 |
WNK3 |
0.735 | -0.180 | 1 | 0.292 |
PKR |
0.734 | -0.048 | 1 | 0.313 |
TSSK2 |
0.734 | -0.085 | -5 | 0.766 |
CK1G1 |
0.734 | 0.071 | -3 | 0.606 |
MNK1 |
0.734 | -0.023 | -2 | 0.596 |
CK1A2 |
0.734 | 0.110 | -3 | 0.613 |
PAK3 |
0.734 | -0.075 | -2 | 0.605 |
MSK2 |
0.733 | -0.040 | -3 | 0.663 |
MELK |
0.733 | -0.063 | -3 | 0.702 |
VRK2 |
0.733 | 0.048 | 1 | 0.399 |
TGFBR1 |
0.733 | -0.058 | -2 | 0.668 |
TTBK2 |
0.733 | -0.137 | 2 | 0.637 |
PIM2 |
0.732 | 0.029 | -3 | 0.670 |
NIM1 |
0.732 | -0.089 | 3 | 0.750 |
QSK |
0.732 | -0.037 | 4 | 0.783 |
ATM |
0.732 | -0.069 | 1 | 0.338 |
NEK9 |
0.732 | -0.193 | 2 | 0.753 |
ANKRD3 |
0.732 | -0.182 | 1 | 0.332 |
SGK3 |
0.731 | -0.011 | -3 | 0.674 |
DCAMKL1 |
0.731 | -0.019 | -3 | 0.686 |
PAK6 |
0.731 | -0.023 | -2 | 0.517 |
CAMK1G |
0.731 | -0.031 | -3 | 0.686 |
AURB |
0.730 | -0.036 | -2 | 0.465 |
CAMK4 |
0.730 | -0.113 | -3 | 0.719 |
PASK |
0.730 | 0.031 | -3 | 0.747 |
GRK6 |
0.730 | -0.128 | 1 | 0.311 |
SIK |
0.730 | -0.037 | -3 | 0.665 |
GRK4 |
0.730 | -0.132 | -2 | 0.677 |
MEK1 |
0.729 | -0.097 | 2 | 0.771 |
MSK1 |
0.729 | -0.030 | -3 | 0.661 |
PKG2 |
0.729 | -0.038 | -2 | 0.474 |
IRE2 |
0.729 | -0.080 | 2 | 0.652 |
PINK1 |
0.729 | 0.096 | 1 | 0.471 |
CHAK1 |
0.728 | -0.109 | 2 | 0.684 |
PKCH |
0.728 | -0.060 | 2 | 0.631 |
TAO3 |
0.728 | 0.004 | 1 | 0.322 |
SMG1 |
0.728 | -0.071 | 1 | 0.351 |
MLK4 |
0.727 | -0.087 | 2 | 0.648 |
QIK |
0.727 | -0.107 | -3 | 0.729 |
TLK2 |
0.727 | -0.106 | 1 | 0.289 |
GRK2 |
0.727 | -0.055 | -2 | 0.591 |
MYLK4 |
0.727 | -0.051 | -2 | 0.579 |
FAM20C |
0.726 | -0.043 | 2 | 0.550 |
MST3 |
0.726 | -0.023 | 2 | 0.761 |
BRSK2 |
0.726 | -0.085 | -3 | 0.706 |
YSK4 |
0.725 | -0.163 | 1 | 0.271 |
CHK1 |
0.725 | -0.051 | -3 | 0.671 |
AKT1 |
0.725 | -0.001 | -3 | 0.646 |
ACVR2A |
0.724 | -0.097 | -2 | 0.627 |
BRSK1 |
0.723 | -0.073 | -3 | 0.683 |
MARK3 |
0.723 | -0.061 | 4 | 0.724 |
PAK2 |
0.723 | -0.090 | -2 | 0.595 |
MAPKAPK5 |
0.723 | -0.076 | -3 | 0.633 |
DCAMKL2 |
0.722 | -0.037 | -3 | 0.709 |
WNK4 |
0.722 | -0.084 | -2 | 0.703 |
ACVR2B |
0.722 | -0.107 | -2 | 0.640 |
PKACA |
0.722 | -0.016 | -2 | 0.431 |
ALK2 |
0.721 | -0.094 | -2 | 0.668 |
BMPR1A |
0.720 | -0.057 | 1 | 0.282 |
PKCI |
0.720 | -0.037 | 2 | 0.654 |
MEK5 |
0.720 | -0.128 | 2 | 0.741 |
NEK2 |
0.720 | -0.171 | 2 | 0.719 |
PKCT |
0.720 | -0.061 | 2 | 0.646 |
LKB1 |
0.719 | -0.014 | -3 | 0.697 |
TLK1 |
0.719 | -0.113 | -2 | 0.674 |
GAK |
0.719 | 0.008 | 1 | 0.355 |
SBK |
0.718 | 0.114 | -3 | 0.540 |
PHKG2 |
0.718 | -0.077 | -3 | 0.716 |
PERK |
0.718 | -0.144 | -2 | 0.668 |
PKCE |
0.718 | -0.004 | 2 | 0.643 |
MARK2 |
0.718 | -0.086 | 4 | 0.704 |
GSK3B |
0.718 | 0.048 | 4 | 0.421 |
GCK |
0.718 | -0.017 | 1 | 0.316 |
IRAK4 |
0.718 | -0.110 | 1 | 0.277 |
MEKK3 |
0.718 | -0.137 | 1 | 0.312 |
PLK1 |
0.718 | -0.198 | -2 | 0.602 |
NEK5 |
0.717 | -0.135 | 1 | 0.312 |
AURA |
0.717 | -0.065 | -2 | 0.451 |
DRAK1 |
0.717 | -0.149 | 1 | 0.313 |
CAMK1D |
0.717 | -0.023 | -3 | 0.603 |
MEKK1 |
0.717 | -0.157 | 1 | 0.302 |
AKT3 |
0.717 | 0.014 | -3 | 0.585 |
SSTK |
0.717 | -0.068 | 4 | 0.808 |
MEKK2 |
0.716 | -0.110 | 2 | 0.721 |
P70S6K |
0.716 | -0.027 | -3 | 0.632 |
ZAK |
0.716 | -0.158 | 1 | 0.281 |
PLK4 |
0.716 | -0.148 | 2 | 0.538 |
NEK11 |
0.716 | -0.091 | 1 | 0.324 |
BRAF |
0.715 | -0.154 | -4 | 0.766 |
BUB1 |
0.715 | 0.051 | -5 | 0.756 |
MAP3K15 |
0.714 | -0.031 | 1 | 0.292 |
SGK1 |
0.714 | 0.031 | -3 | 0.566 |
MEKK6 |
0.714 | -0.058 | 1 | 0.320 |
SMMLCK |
0.713 | -0.060 | -3 | 0.728 |
HRI |
0.713 | -0.185 | -2 | 0.666 |
GRK3 |
0.713 | -0.057 | -2 | 0.560 |
MARK1 |
0.712 | -0.109 | 4 | 0.754 |
PAK5 |
0.712 | -0.059 | -2 | 0.469 |
PDK1 |
0.712 | -0.054 | 1 | 0.332 |
KHS1 |
0.712 | -0.005 | 1 | 0.297 |
DAPK3 |
0.711 | -0.040 | -3 | 0.712 |
SNRK |
0.711 | -0.189 | 2 | 0.573 |
KHS2 |
0.711 | 0.008 | 1 | 0.314 |
HASPIN |
0.711 | 0.064 | -1 | 0.729 |
CK1A |
0.711 | 0.088 | -3 | 0.537 |
HPK1 |
0.711 | -0.048 | 1 | 0.315 |
TAO2 |
0.711 | -0.065 | 2 | 0.769 |
PBK |
0.710 | -0.003 | 1 | 0.328 |
PLK3 |
0.710 | -0.179 | 2 | 0.702 |
CAMK1A |
0.710 | -0.007 | -3 | 0.596 |
TNIK |
0.709 | -0.036 | 3 | 0.880 |
PKN1 |
0.708 | -0.046 | -3 | 0.659 |
HGK |
0.708 | -0.064 | 3 | 0.877 |
PAK4 |
0.708 | -0.053 | -2 | 0.484 |
CHK2 |
0.708 | -0.013 | -3 | 0.595 |
CAMKK2 |
0.708 | -0.132 | -2 | 0.603 |
ROCK2 |
0.708 | 0.001 | -3 | 0.691 |
TTBK1 |
0.706 | -0.140 | 2 | 0.561 |
MRCKB |
0.706 | -0.012 | -3 | 0.661 |
MINK |
0.706 | -0.099 | 1 | 0.285 |
LRRK2 |
0.706 | -0.028 | 2 | 0.747 |
MRCKA |
0.706 | -0.016 | -3 | 0.664 |
DMPK1 |
0.705 | 0.024 | -3 | 0.693 |
NEK8 |
0.705 | -0.178 | 2 | 0.720 |
CAMKK1 |
0.705 | -0.200 | -2 | 0.597 |
DAPK1 |
0.705 | -0.047 | -3 | 0.711 |
NEK4 |
0.705 | -0.155 | 1 | 0.282 |
MST2 |
0.704 | -0.135 | 1 | 0.304 |
SLK |
0.704 | -0.057 | -2 | 0.544 |
LOK |
0.703 | -0.079 | -2 | 0.576 |
EEF2K |
0.703 | -0.062 | 3 | 0.822 |
CRIK |
0.701 | 0.031 | -3 | 0.638 |
MST1 |
0.700 | -0.118 | 1 | 0.286 |
NEK1 |
0.699 | -0.149 | 1 | 0.281 |
CK2A2 |
0.698 | -0.085 | 1 | 0.261 |
TAK1 |
0.698 | -0.168 | 1 | 0.288 |
VRK1 |
0.697 | -0.148 | 2 | 0.745 |
STK33 |
0.697 | -0.120 | 2 | 0.550 |
PDHK3_TYR |
0.696 | 0.172 | 4 | 0.862 |
IRAK1 |
0.696 | -0.248 | -1 | 0.680 |
YSK1 |
0.695 | -0.114 | 2 | 0.728 |
BIKE |
0.693 | -0.024 | 1 | 0.318 |
ROCK1 |
0.692 | -0.025 | -3 | 0.668 |
PKG1 |
0.691 | -0.066 | -2 | 0.397 |
LIMK2_TYR |
0.690 | 0.143 | -3 | 0.751 |
AAK1 |
0.690 | 0.015 | 1 | 0.306 |
YANK3 |
0.690 | -0.015 | 2 | 0.383 |
NEK3 |
0.690 | -0.136 | 1 | 0.294 |
CK2A1 |
0.690 | -0.087 | 1 | 0.251 |
PDHK4_TYR |
0.689 | 0.098 | 2 | 0.810 |
TESK1_TYR |
0.689 | 0.072 | 3 | 0.872 |
PLK2 |
0.689 | -0.117 | -3 | 0.606 |
OSR1 |
0.689 | -0.085 | 2 | 0.728 |
PKMYT1_TYR |
0.687 | 0.120 | 3 | 0.832 |
ASK1 |
0.685 | -0.105 | 1 | 0.280 |
MEK2 |
0.685 | -0.228 | 2 | 0.735 |
MAP2K4_TYR |
0.685 | 0.046 | -1 | 0.791 |
TAO1 |
0.684 | -0.089 | 1 | 0.271 |
MAP2K6_TYR |
0.684 | 0.046 | -1 | 0.804 |
PDHK1_TYR |
0.684 | 0.036 | -1 | 0.813 |
RIPK2 |
0.683 | -0.250 | 1 | 0.260 |
TTK |
0.683 | -0.113 | -2 | 0.643 |
MYO3B |
0.683 | -0.090 | 2 | 0.745 |
MAP2K7_TYR |
0.679 | -0.083 | 2 | 0.777 |
BMPR2_TYR |
0.678 | -0.012 | -1 | 0.791 |
MYO3A |
0.676 | -0.114 | 1 | 0.283 |
LIMK1_TYR |
0.675 | -0.009 | 2 | 0.765 |
PINK1_TYR |
0.675 | -0.139 | 1 | 0.353 |
ALPHAK3 |
0.674 | -0.092 | -1 | 0.682 |
CK1G3 |
0.674 | 0.051 | -3 | 0.497 |
RET |
0.672 | -0.134 | 1 | 0.318 |
MST1R |
0.670 | -0.097 | 3 | 0.787 |
EPHA6 |
0.670 | -0.094 | -1 | 0.750 |
ABL2 |
0.669 | -0.063 | -1 | 0.692 |
EPHB4 |
0.667 | -0.103 | -1 | 0.704 |
ROS1 |
0.667 | -0.134 | 3 | 0.758 |
JAK2 |
0.667 | -0.136 | 1 | 0.325 |
TNNI3K_TYR |
0.667 | -0.038 | 1 | 0.337 |
CSF1R |
0.666 | -0.093 | 3 | 0.758 |
DDR1 |
0.666 | -0.112 | 4 | 0.837 |
ABL1 |
0.666 | -0.064 | -1 | 0.684 |
TXK |
0.666 | -0.066 | 1 | 0.326 |
NEK10_TYR |
0.665 | -0.097 | 1 | 0.258 |
TYRO3 |
0.665 | -0.166 | 3 | 0.793 |
FGR |
0.665 | -0.133 | 1 | 0.337 |
JAK3 |
0.664 | -0.130 | 1 | 0.313 |
TNK1 |
0.664 | -0.047 | 3 | 0.773 |
TNK2 |
0.664 | -0.077 | 3 | 0.720 |
TYK2 |
0.663 | -0.233 | 1 | 0.304 |
STLK3 |
0.662 | -0.204 | 1 | 0.260 |
MET |
0.660 | -0.079 | 3 | 0.761 |
YANK2 |
0.659 | -0.030 | 2 | 0.399 |
YES1 |
0.659 | -0.124 | -1 | 0.738 |
INSRR |
0.659 | -0.146 | 3 | 0.711 |
JAK1 |
0.658 | -0.115 | 1 | 0.287 |
LCK |
0.657 | -0.099 | -1 | 0.710 |
EPHA4 |
0.657 | -0.097 | 2 | 0.704 |
FGFR2 |
0.657 | -0.100 | 3 | 0.742 |
KIT |
0.656 | -0.131 | 3 | 0.754 |
ITK |
0.655 | -0.146 | -1 | 0.659 |
BLK |
0.655 | -0.096 | -1 | 0.716 |
FGFR1 |
0.655 | -0.097 | 3 | 0.720 |
CK1G2 |
0.654 | 0.024 | -3 | 0.556 |
KDR |
0.654 | -0.122 | 3 | 0.704 |
FER |
0.654 | -0.209 | 1 | 0.341 |
DDR2 |
0.653 | -0.052 | 3 | 0.679 |
PDGFRB |
0.652 | -0.221 | 3 | 0.780 |
TEK |
0.652 | -0.084 | 3 | 0.706 |
HCK |
0.652 | -0.175 | -1 | 0.698 |
FLT3 |
0.652 | -0.186 | 3 | 0.784 |
EPHB1 |
0.651 | -0.189 | 1 | 0.330 |
SRMS |
0.650 | -0.195 | 1 | 0.318 |
EPHB3 |
0.650 | -0.171 | -1 | 0.679 |
EPHB2 |
0.650 | -0.162 | -1 | 0.677 |
PDGFRA |
0.648 | -0.208 | 3 | 0.783 |
BMX |
0.648 | -0.129 | -1 | 0.576 |
FYN |
0.648 | -0.090 | -1 | 0.698 |
FLT1 |
0.647 | -0.137 | -1 | 0.726 |
FGFR3 |
0.646 | -0.114 | 3 | 0.706 |
AXL |
0.645 | -0.211 | 3 | 0.732 |
WEE1_TYR |
0.645 | -0.121 | -1 | 0.652 |
MERTK |
0.645 | -0.192 | 3 | 0.734 |
ERBB2 |
0.644 | -0.171 | 1 | 0.282 |
PTK2B |
0.643 | -0.104 | -1 | 0.652 |
TEC |
0.643 | -0.179 | -1 | 0.586 |
PTK2 |
0.643 | -0.046 | -1 | 0.691 |
INSR |
0.642 | -0.176 | 3 | 0.696 |
EPHA3 |
0.642 | -0.155 | 2 | 0.675 |
FRK |
0.641 | -0.165 | -1 | 0.700 |
EPHA7 |
0.641 | -0.153 | 2 | 0.692 |
ALK |
0.641 | -0.200 | 3 | 0.688 |
SYK |
0.640 | -0.064 | -1 | 0.663 |
MATK |
0.640 | -0.117 | -1 | 0.648 |
EGFR |
0.640 | -0.123 | 1 | 0.250 |
BTK |
0.638 | -0.258 | -1 | 0.618 |
FLT4 |
0.638 | -0.194 | 3 | 0.691 |
CSK |
0.638 | -0.132 | 2 | 0.706 |
NTRK1 |
0.638 | -0.256 | -1 | 0.709 |
EPHA1 |
0.638 | -0.190 | 3 | 0.729 |
ZAP70 |
0.637 | -0.028 | -1 | 0.609 |
LTK |
0.637 | -0.212 | 3 | 0.696 |
NTRK3 |
0.637 | -0.186 | -1 | 0.660 |
PTK6 |
0.636 | -0.237 | -1 | 0.592 |
SRC |
0.636 | -0.140 | -1 | 0.692 |
NTRK2 |
0.636 | -0.255 | 3 | 0.717 |
EPHA8 |
0.635 | -0.138 | -1 | 0.670 |
ERBB4 |
0.635 | -0.082 | 1 | 0.268 |
FGFR4 |
0.634 | -0.127 | -1 | 0.645 |
LYN |
0.634 | -0.180 | 3 | 0.678 |
EPHA5 |
0.632 | -0.172 | 2 | 0.677 |
MUSK |
0.627 | -0.172 | 1 | 0.246 |
IGF1R |
0.627 | -0.166 | 3 | 0.632 |
EPHA2 |
0.623 | -0.159 | -1 | 0.627 |
FES |
0.610 | -0.171 | -1 | 0.564 |