Motif 969 (n=138)

Position-wise Probabilities

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uniprot genes site source protein function
A0A096LP49 CCDC187 S775 ochoa Coiled-coil domain-containing protein 187 None
A0A0B4J1V8 PPAN-P2RY11 S238 ochoa HCG2039996 (PPAN-P2RY11 readthrough) None
A6NF01 POM121B S127 ochoa Putative nuclear envelope pore membrane protein POM 121B Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}.
A8CG34 POM121C S520 ochoa Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
H3BNR1 BORCS8-MEF2B S90 ochoa BORCS8-MEF2B readthrough None
O14617 AP3D1 S1068 ochoa AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}.
O60315 ZEB2 S641 ochoa Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}.
O95983 MBD3 S144 ochoa Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}.
P00492 HPRT1 S104 ochoa Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
P02810 PRH1; S24 psp Salivary acidic proline-rich phosphoprotein 1/2 (Db-s) (PRP-1/PRP-2) (Parotid acidic protein) (Pa) (Parotid double-band protein) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) [Cleaved into: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (Db-F) (PIF-F) (PRP-3/PRP-4) (Protein A); Peptide P-C] PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.
P05164 MPO S713 ochoa Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971). {ECO:0000269|PubMed:25698971, ECO:0000269|PubMed:9922160}.
P08493 MGP S25 psp Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein) Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
P0DMU7 CT45A6 T112 ochoa Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) None
P0DMU8 CT45A5 T112 ochoa Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) None
P0DMV0 CT45A7 T112 ochoa Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) None
P12814 ACTN1 S471 ochoa Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}.
P21333 FLNA S1409 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21860 ERBB3 S844 ochoa Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}.
P27348 YWHAQ S210 ochoa 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
P31946 YWHAB S212 ochoa 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.
P35372 OPRM1 S268 psp Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.
P35579 MYH9 S1290 ochoa Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}.
P37173 TGFBR2 S548 ochoa TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. {ECO:0000269|PubMed:7774578}.; FUNCTION: [Isoform 1]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 2]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 3]: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1. {ECO:0000269|PubMed:34568316}.
P38398 BRCA1 S423 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P38398 BRCA1 S1577 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P49327 FASN S1028 psp Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
P49589 CARS1 S305 ochoa Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). {ECO:0000269|PubMed:11347887, ECO:0000269|PubMed:30824121}.
P49790 NUP153 S297 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P52948 NUP98 S656 ochoa Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
P54105 CLNS1A S193 ochoa Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}.
P61981 YWHAG S215 ochoa 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}.
P62258 YWHAE S213 ochoa 14-3-3 protein epsilon (14-3-3E) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}.
P62314 SNRPD1 S59 ochoa Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1) Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000305|PubMed:23333303}.
P63104 YWHAZ S210 ochoa 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}.
P69891 HBG1 S51 ochoa Hemoglobin subunit gamma-1 (Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain) Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:11514664, ECO:0000269|PubMed:22096240, ECO:0000269|PubMed:6198905}.
P69892 HBG2 S51 ochoa Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain) Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:19065339, ECO:0000269|PubMed:21561349, ECO:0000269|PubMed:24502349}.
P78527 PRKDC S2827 ochoa DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
P78559 MAP1A S1324 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q00403 GTF2B S81 ochoa Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}.
Q02080 MEF2B S73 ochoa Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Q02952 AKAP12 S885 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q04206 RELA S281 psp Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}.
Q07157 TJP1 S275 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q07812 BAX S163 psp Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) Plays a role in the mitochondrial apoptotic process (PubMed:10772918, PubMed:11060313, PubMed:16113678, PubMed:16199525, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:36361894, PubMed:8358790, PubMed:8521816). Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis (PubMed:10772918, PubMed:11060313, PubMed:16113678, PubMed:16199525, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816). Promotes activation of CASP3, and thereby apoptosis (PubMed:10772918, PubMed:11060313, PubMed:16113678, PubMed:16199525, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816). {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11060313, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:16199525, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:21458670, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:36361894, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}.
Q07955 SRSF1 S182 ochoa Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.
Q08043 ACTN3 S319 ochoa Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Q12888 TP53BP1 S78 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S103 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S580 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13572 ITPK1 S72 ochoa Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159) Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 (PubMed:11042108, PubMed:8662638). Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 (PubMed:11042108). This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:11042108, PubMed:8662638). Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4 (PubMed:11909533, PubMed:17616525). May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium (PubMed:11909533). Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11042108, ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525, ECO:0000269|PubMed:8662638}.
Q14008 CKAP5 S1471 ochoa Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.
Q14694 USP10 S547 ochoa Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}.
Q14789 GOLGB1 S673 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q15139 PRKD1 S223 psp Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}.
Q15149 PLEC S3853 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15149 PLEC S3975 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q16706 MAN2A1 S80 ochoa Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}.
Q4KMP7 TBC1D10B S277 ochoa TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q5BJF6 ODF2 S115 ochoa Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}.
Q5HYN5 CT45A1 T112 ochoa Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) None
Q5JSZ5 PRRC2B S166 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5THJ4 VPS13D S1707 ochoa Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.
Q5THK1 PRR14L S1969 ochoa Protein PRR14L (Proline rich 14-like protein) None
Q658Y4 FAM91A1 S671 ochoa Protein FAM91A1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.
Q68CZ2 TNS3 S337 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q68EM7 ARHGAP17 S845 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6P996 PDXDC1 S736 ochoa Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) None
Q6WKZ4 RAB11FIP1 S266 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZU65 UBN2 S631 ochoa Ubinuclein-2 None
Q6ZVM7 TOM1L2 S424 ochoa TOM1-like protein 2 (Target of Myb-like protein 2) Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}.
Q7Z2T5 TRMT1L S707 ochoa tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}.
Q7Z2Z1 TICRR S923 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z3B3 KANSL1 S115 ochoa KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q7Z3T8 ZFYVE16 S168 ochoa Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}.
Q86UX7 FERMT3 S328 ochoa Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}.
Q86XZ4 SPATS2 S210 ochoa Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) None
Q86Y13 DZIP3 S707 ochoa E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. {ECO:0000269|PubMed:12538761}.
Q8N9U0 TC2N S172 ochoa Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) None
Q8NF91 SYNE1 S8663 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NFG4 FLCN S537 psp Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}.
Q8NHU0 CT45A3 T112 ochoa Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) None
Q8TCU6 PREX1 S1200 ochoa Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Q8TDD1 DDX54 S696 ochoa ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}.
Q8WZA1 POMGNT1 S66 ochoa Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2) Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity. {ECO:0000269|PubMed:11709191, ECO:0000269|PubMed:11742540, ECO:0000269|PubMed:26908613, ECO:0000269|PubMed:27391550, ECO:0000269|PubMed:27493216, ECO:0000269|PubMed:28512129}.
Q969U7 PSMG2 S37 ochoa Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1) Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.
Q96EV2 RBM33 S54 ochoa RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}.
Q96HA1 POM121 S543 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96JN0 LCOR S72 ochoa Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2) May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}.
Q9BSC4 NOL10 S632 ochoa Nucleolar protein 10 None
Q9BVJ6 UTP14A S29 ochoa U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) May be required for ribosome biogenesis. {ECO:0000250}.
Q9H0K1 SIK2 S512 psp Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}.
Q9H1A4 ANAPC1 S555 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H2Y7 ZNF106 S554 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H792 PEAK1 S212 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9H8M2 BRD9 S43 ochoa Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}.
Q9H9L4 KANSL2 S134 ochoa KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac) (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). {ECO:0000250|UniProtKB:Q8BQR4, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:33657400}.
Q9HB19 PLEKHA2 S273 ochoa Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}.
Q9NPG3 UBN1 S321 ochoa Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
Q9NQ55 PPAN S238 ochoa Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) May have a role in cell growth.
Q9NRF8 CTPS2 S562 ochoa CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2) Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339}.
Q9NS91 RAD18 S55 ochoa E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}.
Q9NSI6 BRWD1 S1276 ochoa Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Q9NX02 NLRP2 S669 ochoa NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases. {ECO:0000269|PubMed:15456791}.
Q9NZ63 C9orf78 S101 ochoa Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}.
Q9UGU0 TCF20 S1303 ochoa Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.
Q9UHD2 TBK1 S509 ochoa Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}.
Q9UJV9 DDX41 S66 ochoa Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}.
Q9UK58 CCNL1 S65 ochoa Cyclin-L1 (Cyclin-L) Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}.
Q9ULH0 KIDINS220 S1526 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9UPM8 AP4E1 S855 ochoa AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}.
Q9Y2H0 DLGAP4 S707 ochoa Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Q9Y2H5 PLEKHA6 S919 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
P07737 PFN1 S85 Sugiyama Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.
P07602 PSAP S29 Sugiyama Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250|UniProtKB:Q61207, ECO:0000269|PubMed:10383054}.; FUNCTION: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
Q13242 SRSF9 S172 Sugiyama Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}.
O00116 AGPS S174 Sugiyama Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}.
P49327 FASN S2465 Sugiyama Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
Q04864 REL S516 GPS6 Proto-oncogene c-Rel Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
P13489 RNH1 S208 Sugiyama Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}.
O15111 CHUK S356 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}.
O15146 MUSK S567 Sugiyama Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}.
Q13049 TRIM32 S55 SIGNOR E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:19349376, PubMed:31123703). Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 (PubMed:22745133). Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (PubMed:37543647). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions (PubMed:32918979). Ubiquitinates XIAP and targets it for proteasomal degradation (PubMed:21628460). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376). May ubiquitinate BBS2 (PubMed:22500027). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703). Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (PubMed:34888944). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-45' to initiate autophagy (PubMed:37943659). {ECO:0000250|UniProtKB:Q8CH72, ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:21628460, ECO:0000269|PubMed:22500027, ECO:0000269|PubMed:22745133, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32918979, ECO:0000269|PubMed:34888944, ECO:0000269|PubMed:37543647, ECO:0000269|PubMed:37943659}.; FUNCTION: (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269). Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269). {ECO:0000269|PubMed:7778269}.
Q04917 YWHAH S215 Sugiyama 14-3-3 protein eta (Protein AS1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
P05771 PRKCB S476 Sugiyama Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}.
P17252 PRKCA S473 Sugiyama Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}.
O00443 PIK3C2A S58 Sugiyama Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}.
P31947 SFN S212 Sugiyama 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}.
P09619 PDGFRB S980 Sugiyama Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.
P41743 PRKCI S388 Sugiyama Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}.
P42684 ABL2 S962 Sugiyama Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.
O60563 CCNT1 S444 Sugiyama Cyclin-T1 (CycT1) (Cyclin-T) Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}.
Q13459 MYO9B S1308 Sugiyama Unconventional myosin-IXb (Unconventional myosin-9b) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.
O75828 CBR3 S69 Sugiyama Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:15537833, PubMed:18493841, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672). {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841, ECO:0000269|PubMed:19841672}.
P16152 CBR1 S69 Sugiyama Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}.
Q5S007 LRRK2 S1536 EPSD|PSP Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}.
Q8IW41 MAPKAPK5 S438 Sugiyama MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}.
P12109 COL6A1 S201 Sugiyama Collagen alpha-1(VI) chain Collagen VI acts as a cell-binding protein.
Q9Y243 AKT3 S136 Sugiyama RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.
Download
reactome_id name p -log10_p
R-HSA-9705683 SARS-CoV-2-host interactions 6.708745e-12 11.173
R-HSA-111447 Activation of BAD and translocation to mitochondria 2.454126e-11 10.610
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 2.454126e-11 10.610
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 5.183406e-10 9.285
R-HSA-9694516 SARS-CoV-2 Infection 7.543848e-10 9.122
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 1.110908e-09 8.954
R-HSA-114452 Activation of BH3-only proteins 3.545245e-09 8.450
R-HSA-9614399 Regulation of localization of FOXO transcription factors 7.287466e-09 8.137
R-HSA-109606 Intrinsic Pathway for Apoptosis 1.843609e-08 7.734
R-HSA-191859 snRNP Assembly 2.716234e-08 7.566
R-HSA-194441 Metabolism of non-coding RNA 2.716234e-08 7.566
R-HSA-9679506 SARS-CoV Infections 5.439131e-08 7.264
R-HSA-69473 G2/M DNA damage checkpoint 1.478635e-07 6.830
R-HSA-1640170 Cell Cycle 1.959134e-07 6.708
R-HSA-2980766 Nuclear Envelope Breakdown 3.156552e-07 6.501
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.610110e-06 5.793
R-HSA-69481 G2/M Checkpoints 1.639871e-06 5.785
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.610110e-06 5.793
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.766256e-06 5.753
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.065253e-06 5.685
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.065253e-06 5.685
R-HSA-109581 Apoptosis 1.908709e-06 5.719
R-HSA-1855170 IPs transport between nucleus and cytosol 2.787410e-06 5.555
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.787410e-06 5.555
R-HSA-9692914 SARS-CoV-1-host interactions 2.907929e-06 5.536
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.218836e-06 5.492
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.218836e-06 5.492
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 3.474690e-06 5.459
R-HSA-180746 Nuclear import of Rev protein 3.703124e-06 5.431
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 4.245095e-06 5.372
R-HSA-69620 Cell Cycle Checkpoints 4.069083e-06 5.391
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 4.879218e-06 5.312
R-HSA-180910 Vpr-mediated nuclear import of PICs 5.522839e-06 5.258
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 6.269737e-06 5.203
R-HSA-3700989 Transcriptional Regulation by TP53 6.297031e-06 5.201
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 7.096588e-06 5.149
R-HSA-168276 NS1 Mediated Effects on Host Pathways 7.096588e-06 5.149
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 8.009743e-06 5.096
R-HSA-177243 Interactions of Rev with host cellular proteins 8.009743e-06 5.096
R-HSA-176033 Interactions of Vpr with host cellular proteins 8.009743e-06 5.096
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 9.015880e-06 5.045
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 1.352166e-05 4.869
R-HSA-5357801 Programmed Cell Death 1.529789e-05 4.815
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 1.569889e-05 4.804
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 1.742241e-05 4.759
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 4.254712e-05 4.371
R-HSA-5628897 TP53 Regulates Metabolic Genes 4.263368e-05 4.370
R-HSA-68875 Mitotic Prophase 5.856564e-05 4.232
R-HSA-168325 Viral Messenger RNA Synthesis 6.727825e-05 4.172
R-HSA-6784531 tRNA processing in the nucleus 7.276252e-05 4.138
R-HSA-5603029 IkBA variant leads to EDA-ID 7.326173e-05 4.135
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 8.516470e-05 4.070
R-HSA-9730414 MITF-M-regulated melanocyte development 1.093666e-04 3.961
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 1.364681e-04 3.865
R-HSA-9678108 SARS-CoV-1 Infection 1.365996e-04 3.865
R-HSA-5578749 Transcriptional regulation by small RNAs 1.497197e-04 3.825
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 1.399450e-04 3.854
R-HSA-74160 Gene expression (Transcription) 1.689827e-04 3.772
R-HSA-68886 M Phase 1.795904e-04 3.746
R-HSA-1169408 ISG15 antiviral mechanism 1.823235e-04 3.739
R-HSA-162599 Late Phase of HIV Life Cycle 1.957529e-04 3.708
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.957529e-04 3.708
R-HSA-1483249 Inositol phosphate metabolism 2.392770e-04 3.621
R-HSA-69278 Cell Cycle, Mitotic 2.201052e-04 3.657
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.166284e-04 3.499
R-HSA-9824446 Viral Infection Pathways 3.347759e-04 3.475
R-HSA-162587 HIV Life Cycle 3.548350e-04 3.450
R-HSA-3371556 Cellular response to heat stress 3.970061e-04 3.401
R-HSA-162909 Host Interactions of HIV factors 4.519864e-04 3.345
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.076941e-04 3.150
R-HSA-9614085 FOXO-mediated transcription 7.973472e-04 3.098
R-HSA-70171 Glycolysis 8.351968e-04 3.078
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 9.074109e-04 3.042
R-HSA-3270619 IRF3-mediated induction of type I IFN 9.074109e-04 3.042
R-HSA-162582 Signal Transduction 1.119550e-03 2.951
R-HSA-211000 Gene Silencing by RNA 1.190223e-03 2.924
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 1.207885e-03 2.918
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 1.207885e-03 2.918
R-HSA-2028269 Signaling by Hippo 1.378955e-03 2.860
R-HSA-1834941 STING mediated induction of host immune responses 1.765015e-03 2.753
R-HSA-5683826 Surfactant metabolism 1.789055e-03 2.747
R-HSA-8953854 Metabolism of RNA 1.829464e-03 2.738
R-HSA-70326 Glucose metabolism 1.926554e-03 2.715
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 2.212689e-03 2.655
R-HSA-199991 Membrane Trafficking 2.424816e-03 2.615
R-HSA-1169091 Activation of NF-kappaB in B cells 2.813663e-03 2.551
R-HSA-5688890 Defective CSF2RA causes SMDP4 2.871662e-03 2.542
R-HSA-5688849 Defective CSF2RB causes SMDP5 2.871662e-03 2.542
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 2.871662e-03 2.542
R-HSA-162906 HIV Infection 3.116796e-03 2.506
R-HSA-933542 TRAF6 mediated NF-kB activation 3.303777e-03 2.481
R-HSA-114516 Disinhibition of SNARE formation 4.430143e-03 2.354
R-HSA-73857 RNA Polymerase II Transcription 4.523626e-03 2.345
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 5.326458e-03 2.274
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 5.395326e-03 2.268
R-HSA-380259 Loss of Nlp from mitotic centrosomes 5.395326e-03 2.268
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.054955e-03 2.218
R-HSA-8854518 AURKA Activation by TPX2 6.226071e-03 2.206
R-HSA-170984 ARMS-mediated activation 6.298733e-03 2.201
R-HSA-430116 GP1b-IX-V activation signalling 6.298733e-03 2.201
R-HSA-448706 Interleukin-1 processing 6.298733e-03 2.201
R-HSA-73887 Death Receptor Signaling 7.148016e-03 2.146
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 7.460201e-03 2.127
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.343205e-03 2.134
R-HSA-9610379 HCMV Late Events 7.745107e-03 2.111
R-HSA-5663205 Infectious disease 8.339653e-03 2.079
R-HSA-9832991 Formation of the posterior neural plate 8.465027e-03 2.072
R-HSA-163765 ChREBP activates metabolic gene expression 8.465027e-03 2.072
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 8.484704e-03 2.071
R-HSA-76002 Platelet activation, signaling and aggregation 8.596339e-03 2.066
R-HSA-380287 Centrosome maturation 9.216455e-03 2.035
R-HSA-5687868 Defective SFTPA2 causes IPF 9.702661e-03 2.013
R-HSA-5619102 SLC transporter disorders 9.995771e-03 2.000
R-HSA-212436 Generic Transcription Pathway 1.016967e-02 1.993
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 1.038928e-02 1.983
R-HSA-198323 AKT phosphorylates targets in the cytosol 1.091698e-02 1.962
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 1.091698e-02 1.962
R-HSA-5687613 Diseases associated with surfactant metabolism 1.091698e-02 1.962
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.301523e-02 1.886
R-HSA-5602358 Diseases associated with the TLR signaling cascade 1.126923e-02 1.948
R-HSA-5260271 Diseases of Immune System 1.126923e-02 1.948
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 1.224640e-02 1.912
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 1.114260e-02 1.953
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 1.114260e-02 1.953
R-HSA-72306 tRNA processing 1.101460e-02 1.958
R-HSA-114608 Platelet degranulation 1.320726e-02 1.879
R-HSA-168255 Influenza Infection 1.357226e-02 1.867
R-HSA-391160 Signal regulatory protein family interactions 1.364289e-02 1.865
R-HSA-72165 mRNA Splicing - Minor Pathway 1.627321e-02 1.789
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 1.789703e-02 1.747
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.550032e-02 1.810
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 1.549384e-02 1.810
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.657233e-02 1.781
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 1.707425e-02 1.768
R-HSA-169893 Prolonged ERK activation events 1.663139e-02 1.779
R-HSA-193639 p75NTR signals via NF-kB 1.510501e-02 1.821
R-HSA-9823739 Formation of the anterior neural plate 1.510501e-02 1.821
R-HSA-446353 Cell-extracellular matrix interactions 1.510501e-02 1.821
R-HSA-5099900 WNT5A-dependent internalization of FZD4 1.663139e-02 1.779
R-HSA-168898 Toll-like Receptor Cascades 1.759303e-02 1.755
R-HSA-5653656 Vesicle-mediated transport 1.599285e-02 1.796
R-HSA-1500931 Cell-Cell communication 1.785987e-02 1.748
R-HSA-4839726 Chromatin organization 1.697977e-02 1.770
R-HSA-72163 mRNA Splicing - Major Pathway 1.871363e-02 1.728
R-HSA-114294 Activation, translocation and oligomerization of BAX 1.931177e-02 1.714
R-HSA-3642279 TGFBR2 MSI Frameshift Mutants in Cancer 1.931177e-02 1.714
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 1.931177e-02 1.714
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 1.931177e-02 1.714
R-HSA-9609690 HCMV Early Events 1.948729e-02 1.710
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 2.006284e-02 1.698
R-HSA-1280215 Cytokine Signaling in Immune system 2.095047e-02 1.679
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 2.158250e-02 1.666
R-HSA-4419969 Depolymerization of the Nuclear Lamina 2.158250e-02 1.666
R-HSA-432722 Golgi Associated Vesicle Biogenesis 2.233806e-02 1.651
R-HSA-72172 mRNA Splicing 2.323928e-02 1.634
R-HSA-193704 p75 NTR receptor-mediated signalling 2.329323e-02 1.633
R-HSA-392517 Rap1 signalling 2.335243e-02 1.632
R-HSA-844456 The NLRP3 inflammasome 2.335243e-02 1.632
R-HSA-1643685 Disease 2.481247e-02 1.605
R-HSA-373753 Nephrin family interactions 2.517998e-02 1.599
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 2.628416e-02 1.580
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 2.831928e-02 1.548
R-HSA-176034 Interactions of Tat with host cellular proteins 2.882824e-02 1.540
R-HSA-5602636 IKBKB deficiency causes SCID 2.882824e-02 1.540
R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 2.882824e-02 1.540
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 2.882824e-02 1.540
R-HSA-9603505 NTRK3 as a dependence receptor 2.882824e-02 1.540
R-HSA-1227986 Signaling by ERBB2 2.947272e-02 1.531
R-HSA-3642278 Loss of Function of TGFBR2 in Cancer 3.825293e-02 1.417
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer 3.825293e-02 1.417
R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer 3.825293e-02 1.417
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 3.948177e-02 1.404
R-HSA-5218921 VEGFR2 mediated cell proliferation 3.728542e-02 1.428
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 3.227518e-02 1.491
R-HSA-166166 MyD88-independent TLR4 cascade 3.227518e-02 1.491
R-HSA-1266695 Interleukin-7 signaling 3.728542e-02 1.428
R-HSA-2219528 PI3K/AKT Signaling in Cancer 4.111414e-02 1.386
R-HSA-3000170 Syndecan interactions 3.304122e-02 1.481
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 3.304122e-02 1.481
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 3.170699e-02 1.499
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 3.948177e-02 1.404
R-HSA-3247509 Chromatin modifying enzymes 3.916038e-02 1.407
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 3.402763e-02 1.468
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 4.172611e-02 1.380
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 4.236318e-02 1.373
R-HSA-622312 Inflammasomes 4.401729e-02 1.356
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.416307e-02 1.355
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 4.416307e-02 1.355
R-HSA-913531 Interferon Signaling 4.537912e-02 1.343
R-HSA-9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage 4.758675e-02 1.323
R-HSA-3249367 STAT6-mediated induction of chemokines 4.758675e-02 1.323
R-HSA-8875513 MET interacts with TNS proteins 4.758675e-02 1.323
R-HSA-5619115 Disorders of transmembrane transporters 4.779584e-02 1.321
R-HSA-1250196 SHC1 events in ERBB2 signaling 4.873581e-02 1.312
R-HSA-8863795 Downregulation of ERBB2 signaling 4.873581e-02 1.312
R-HSA-9609646 HCMV Infection 4.994351e-02 1.302
R-HSA-399719 Trafficking of AMPA receptors 5.116097e-02 1.291
R-HSA-69275 G2/M Transition 5.138028e-02 1.289
R-HSA-109582 Hemostasis 5.209254e-02 1.283
R-HSA-4086400 PCP/CE pathway 5.264005e-02 1.279
R-HSA-453274 Mitotic G2-G2/M phases 5.313172e-02 1.275
R-HSA-111465 Apoptotic cleavage of cellular proteins 5.362865e-02 1.271
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 5.613782e-02 1.251
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 5.613782e-02 1.251
R-HSA-1306955 GRB7 events in ERBB2 signaling 5.683055e-02 1.245
R-HSA-3656532 TGFBR1 KD Mutants in Cancer 5.683055e-02 1.245
R-HSA-191650 Regulation of gap junction activity 5.683055e-02 1.245
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 5.683055e-02 1.245
R-HSA-211163 AKT-mediated inactivation of FOXO1A 5.683055e-02 1.245
R-HSA-205025 NADE modulates death signalling 5.683055e-02 1.245
R-HSA-68877 Mitotic Prometaphase 5.766140e-02 1.239
R-HSA-5686938 Regulation of TLR by endogenous ligand 6.127650e-02 1.213
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 6.598520e-02 1.181
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 6.598520e-02 1.181
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 7.505155e-02 1.125
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 9.292274e-02 1.032
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 9.292274e-02 1.032
R-HSA-446107 Type I hemidesmosome assembly 1.017292e-01 0.993
R-HSA-9660537 Signaling by MRAS-complex mutants 1.017292e-01 0.993
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.017292e-01 0.993
R-HSA-198693 AKT phosphorylates targets in the nucleus 1.104508e-01 0.957
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.528124e-01 0.816
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.528124e-01 0.816
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 1.610410e-01 0.793
R-HSA-6785631 ERBB2 Regulates Cell Motility 1.691902e-01 0.772
R-HSA-176412 Phosphorylation of the APC/C 1.772607e-01 0.751
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 1.772607e-01 0.751
R-HSA-72187 mRNA 3'-end processing 1.167287e-01 0.933
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 1.691902e-01 0.772
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 8.042278e-02 1.095
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 8.403045e-02 1.076
R-HSA-69618 Mitotic Spindle Checkpoint 9.539758e-02 1.020
R-HSA-186797 Signaling by PDGF 1.494992e-01 0.825
R-HSA-1606341 IRF3 mediated activation of type 1 IFN 6.598520e-02 1.181
R-HSA-8857538 PTK6 promotes HIF1A stabilization 8.403045e-02 1.076
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 1.017292e-01 0.993
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 1.361138e-01 0.866
R-HSA-1221632 Meiotic synapsis 1.199172e-01 0.921
R-HSA-167172 Transcription of the HIV genome 1.699503e-01 0.770
R-HSA-9758274 Regulation of NF-kappa B signaling 1.772607e-01 0.751
R-HSA-111457 Release of apoptotic factors from the mitochondria 7.505155e-02 1.125
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 7.505155e-02 1.125
R-HSA-9839389 TGFBR3 regulates TGF-beta signaling 9.292274e-02 1.032
R-HSA-8932506 DAG1 core M1 glycosylations 9.292274e-02 1.032
R-HSA-176974 Unwinding of DNA 1.104508e-01 0.957
R-HSA-75896 Plasmalogen biosynthesis 1.361138e-01 0.866
R-HSA-209560 NF-kB is activated and signals survival 1.361138e-01 0.866
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.852534e-01 0.732
R-HSA-170968 Frs2-mediated activation 1.528124e-01 0.816
R-HSA-918233 TRAF3-dependent IRF activation pathway 1.852534e-01 0.732
R-HSA-9010642 ROBO receptors bind AKAP5 1.017292e-01 0.993
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 1.361138e-01 0.866
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 1.852534e-01 0.732
R-HSA-187687 Signalling to ERKs 6.390401e-02 1.194
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 1.167287e-01 0.933
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 1.394755e-01 0.856
R-HSA-8932504 DAG1 core M2 glycosylations 1.017292e-01 0.993
R-HSA-9734207 Nucleotide salvage defects 1.017292e-01 0.993
R-HSA-2179392 EGFR Transactivation by Gastrin 1.190882e-01 0.924
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.691902e-01 0.772
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 1.691902e-01 0.772
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.852534e-01 0.732
R-HSA-5607764 CLEC7A (Dectin-1) signaling 8.780766e-02 1.056
R-HSA-9020702 Interleukin-1 signaling 9.733599e-02 1.012
R-HSA-69052 Switching of origins to a post-replicative state 1.873292e-01 0.727
R-HSA-199418 Negative regulation of the PI3K/AKT network 1.691774e-01 0.772
R-HSA-5693606 DNA Double Strand Break Response 1.665084e-01 0.779
R-HSA-9818749 Regulation of NFE2L2 gene expression 8.403045e-02 1.076
R-HSA-8941413 Events associated with phagocytolytic activity of PMN cells 1.691902e-01 0.772
R-HSA-399997 Acetylcholine regulates insulin secretion 1.852534e-01 0.732
R-HSA-5660668 CLEC7A/inflammasome pathway 7.505155e-02 1.125
R-HSA-937039 IRAK1 recruits IKK complex 1.445035e-01 0.840
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.445035e-01 0.840
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 1.610410e-01 0.793
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.691902e-01 0.772
R-HSA-73856 RNA Polymerase II Transcription Termination 1.461416e-01 0.835
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1.134044e-01 0.945
R-HSA-418597 G alpha (z) signalling events 1.263579e-01 0.898
R-HSA-446652 Interleukin-1 family signaling 8.589609e-02 1.066
R-HSA-9006925 Intracellular signaling by second messengers 1.440451e-01 0.842
R-HSA-9762293 Regulation of CDH11 gene transcription 1.104508e-01 0.957
R-HSA-975871 MyD88 cascade initiated on plasma membrane 9.156953e-02 1.038
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 9.156953e-02 1.038
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 9.156953e-02 1.038
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 7.505155e-02 1.125
R-HSA-193692 Regulated proteolysis of p75NTR 1.104508e-01 0.957
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 1.104508e-01 0.957
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 1.276422e-01 0.894
R-HSA-9735804 Diseases of nucleotide metabolism 1.528124e-01 0.816
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 1.772607e-01 0.751
R-HSA-975155 MyD88 dependent cascade initiated on endosome 1.154804e-01 0.937
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 9.451863e-02 1.024
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 1.414581e-01 0.849
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 1.414581e-01 0.849
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1.239259e-01 0.907
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 1.304036e-01 0.885
R-HSA-3000178 ECM proteoglycans 1.803459e-01 0.744
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 7.505155e-02 1.125
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 1.231271e-01 0.910
R-HSA-376176 Signaling by ROBO receptors 1.725685e-01 0.763
R-HSA-5617833 Cilium Assembly 1.485800e-01 0.828
R-HSA-8853884 Transcriptional Regulation by VENTX 8.042278e-02 1.095
R-HSA-2559583 Cellular Senescence 1.310918e-01 0.882
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins 7.505155e-02 1.125
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 1.104508e-01 0.957
R-HSA-8941332 RUNX2 regulates genes involved in cell migration 1.276422e-01 0.894
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 8.035584e-02 1.095
R-HSA-1433559 Regulation of KIT signaling 1.610410e-01 0.793
R-HSA-5357905 Regulation of TNFR1 signaling 9.809175e-02 1.008
R-HSA-75893 TNF signaling 1.296088e-01 0.887
R-HSA-73893 DNA Damage Bypass 1.073000e-01 0.969
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.873292e-01 0.727
R-HSA-9007101 Rab regulation of trafficking 1.369987e-01 0.863
R-HSA-8848021 Signaling by PTK6 1.528724e-01 0.816
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 1.528724e-01 0.816
R-HSA-9662834 CD163 mediating an anti-inflammatory response 1.276422e-01 0.894
R-HSA-209543 p75NTR recruits signalling complexes 1.445035e-01 0.840
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 1.630791e-01 0.788
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.017292e-01 0.993
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1.104508e-01 0.957
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.528124e-01 0.816
R-HSA-446728 Cell junction organization 1.674298e-01 0.776
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 9.271444e-02 1.033
R-HSA-1483255 PI Metabolism 9.929041e-02 1.003
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.325892e-01 0.877
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 6.390401e-02 1.194
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 9.809175e-02 1.008
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 9.809175e-02 1.008
R-HSA-9706369 Negative regulation of FLT3 1.772607e-01 0.751
R-HSA-168256 Immune System 1.342476e-01 0.872
R-HSA-194138 Signaling by VEGF 1.574370e-01 0.803
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 1.394755e-01 0.856
R-HSA-5633007 Regulation of TP53 Activity 9.748096e-02 1.011
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 1.190882e-01 0.924
R-HSA-8983711 OAS antiviral response 1.445035e-01 0.840
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 1.167287e-01 0.933
R-HSA-8953750 Transcriptional Regulation by E2F6 7.477922e-02 1.126
R-HSA-3858494 Beta-catenin independent WNT signaling 1.884637e-01 0.725
R-HSA-449147 Signaling by Interleukins 1.810640e-01 0.742
R-HSA-163685 Integration of energy metabolism 1.884637e-01 0.725
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 1.528724e-01 0.816
R-HSA-9607240 FLT3 Signaling 8.042278e-02 1.095
R-HSA-3214841 PKMTs methylate histone lysines 8.042278e-02 1.095
R-HSA-9755511 KEAP1-NFE2L2 pathway 8.449818e-02 1.073
R-HSA-2262752 Cellular responses to stress 8.335032e-02 1.079
R-HSA-8953897 Cellular responses to stimuli 1.052831e-01 0.978
R-HSA-8878166 Transcriptional regulation by RUNX2 1.414581e-01 0.849
R-HSA-9856651 MITF-M-dependent gene expression 8.311162e-02 1.080
R-HSA-75153 Apoptotic execution phase 9.809175e-02 1.008
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 6.390401e-02 1.194
R-HSA-674695 RNA Polymerase II Pre-transcription Events 1.908352e-01 0.719
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1.931688e-01 0.714
R-HSA-1963642 PI3K events in ERBB2 signaling 1.931688e-01 0.714
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 1.931688e-01 0.714
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 1.931688e-01 0.714
R-HSA-8852135 Protein ubiquitination 1.943500e-01 0.711
R-HSA-3000171 Non-integrin membrane-ECM interactions 1.943500e-01 0.711
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 1.943500e-01 0.711
R-HSA-1257604 PIP3 activates AKT signaling 1.952429e-01 0.709
R-HSA-68882 Mitotic Anaphase 1.997859e-01 0.699
R-HSA-111471 Apoptotic factor-mediated response 2.010079e-01 0.697
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 2.014041e-01 0.696
R-HSA-2555396 Mitotic Metaphase and Anaphase 2.017787e-01 0.695
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 2.084878e-01 0.681
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 2.087713e-01 0.680
R-HSA-9709603 Impaired BRCA2 binding to PALB2 2.087713e-01 0.680
R-HSA-937041 IKK complex recruitment mediated by RIP1 2.087713e-01 0.680
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 2.087713e-01 0.680
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 2.087713e-01 0.680
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 2.120395e-01 0.674
R-HSA-5693607 Processing of DNA double-strand break ends 2.155973e-01 0.666
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 2.164597e-01 0.665
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.164597e-01 0.665
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.164597e-01 0.665
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 2.164597e-01 0.665
R-HSA-8848584 Wax and plasmalogen biosynthesis 2.164597e-01 0.665
R-HSA-389513 Co-inhibition by CTLA4 2.164597e-01 0.665
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 2.164597e-01 0.665
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 2.191605e-01 0.659
R-HSA-8878171 Transcriptional regulation by RUNX1 2.199740e-01 0.658
R-HSA-69242 S Phase 2.209046e-01 0.656
R-HSA-166520 Signaling by NTRKs 2.209046e-01 0.656
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 2.227289e-01 0.652
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 2.240739e-01 0.650
R-HSA-202040 G-protein activation 2.240739e-01 0.650
R-HSA-5357786 TNFR1-induced proapoptotic signaling 2.240739e-01 0.650
R-HSA-9939291 Matriglycan biosynthesis on DAG1 2.240739e-01 0.650
R-HSA-5687128 MAPK6/MAPK4 signaling 2.298793e-01 0.639
R-HSA-1500620 Meiosis 2.298793e-01 0.639
R-HSA-9034015 Signaling by NTRK3 (TRKC) 2.316146e-01 0.635
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.334604e-01 0.632
R-HSA-141424 Amplification of signal from the kinetochores 2.334604e-01 0.632
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 2.334604e-01 0.632
R-HSA-5693532 DNA Double-Strand Break Repair 2.336754e-01 0.631
R-HSA-69306 DNA Replication 2.336754e-01 0.631
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 2.370450e-01 0.625
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 2.370450e-01 0.625
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 2.390824e-01 0.621
R-HSA-166208 mTORC1-mediated signalling 2.390824e-01 0.621
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway 2.390824e-01 0.621
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 2.464781e-01 0.608
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 2.464781e-01 0.608
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 2.464781e-01 0.608
R-HSA-202424 Downstream TCR signaling 2.514096e-01 0.600
R-HSA-9006936 Signaling by TGFB family members 2.517689e-01 0.599
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 2.538024e-01 0.596
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.538024e-01 0.596
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 2.538024e-01 0.596
R-HSA-9836573 Mitochondrial RNA degradation 2.538024e-01 0.596
R-HSA-8863678 Neurodegenerative Diseases 2.538024e-01 0.596
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 2.538024e-01 0.596
R-HSA-8986944 Transcriptional Regulation by MECP2 2.550055e-01 0.593
R-HSA-1474244 Extracellular matrix organization 2.587408e-01 0.587
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 2.610560e-01 0.583
R-HSA-420029 Tight junction interactions 2.610560e-01 0.583
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 2.610560e-01 0.583
R-HSA-9932444 ATP-dependent chromatin remodelers 2.610560e-01 0.583
R-HSA-9932451 SWI/SNF chromatin remodelers 2.610560e-01 0.583
R-HSA-400685 Sema4D in semaphorin signaling 2.610560e-01 0.583
R-HSA-2467813 Separation of Sister Chromatids 2.622013e-01 0.581
R-HSA-68867 Assembly of the pre-replicative complex 2.657983e-01 0.575
R-HSA-9703465 Signaling by FLT3 fusion proteins 2.682395e-01 0.571
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 2.682395e-01 0.571
R-HSA-5689901 Metalloprotease DUBs 2.682395e-01 0.571
R-HSA-525793 Myogenesis 2.682395e-01 0.571
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 2.693966e-01 0.570
R-HSA-1474290 Collagen formation 2.693966e-01 0.570
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.753536e-01 0.560
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.753536e-01 0.560
R-HSA-389357 CD28 dependent PI3K/Akt signaling 2.753536e-01 0.560
R-HSA-3928663 EPHA-mediated growth cone collapse 2.753536e-01 0.560
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 2.753536e-01 0.560
R-HSA-201451 Signaling by BMP 2.753536e-01 0.560
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.753536e-01 0.560
R-HSA-597592 Post-translational protein modification 2.818457e-01 0.550
R-HSA-167287 HIV elongation arrest and recovery 2.823989e-01 0.549
R-HSA-167290 Pausing and recovery of HIV elongation 2.823989e-01 0.549
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 2.823989e-01 0.549
R-HSA-5620971 Pyroptosis 2.823989e-01 0.549
R-HSA-5621481 C-type lectin receptors (CLRs) 2.832214e-01 0.548
R-HSA-388841 Regulation of T cell activation by CD28 family 2.833115e-01 0.548
R-HSA-170834 Signaling by TGF-beta Receptor Complex 2.837836e-01 0.547
R-HSA-9909648 Regulation of PD-L1(CD274) expression 2.858606e-01 0.544
R-HSA-5683057 MAPK family signaling cascades 2.884468e-01 0.540
R-HSA-9709570 Impaired BRCA2 binding to RAD51 2.893762e-01 0.539
R-HSA-9664565 Signaling by ERBB2 KD Mutants 2.893762e-01 0.539
R-HSA-5656169 Termination of translesion DNA synthesis 2.893762e-01 0.539
R-HSA-9759475 Regulation of CDH11 Expression and Function 2.893762e-01 0.539
R-HSA-210745 Regulation of gene expression in beta cells 2.893762e-01 0.539
R-HSA-3214847 HATs acetylate histones 2.909691e-01 0.536
R-HSA-68962 Activation of the pre-replicative complex 2.962861e-01 0.528
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 2.962861e-01 0.528
R-HSA-1227990 Signaling by ERBB2 in Cancer 2.962861e-01 0.528
R-HSA-9008059 Interleukin-37 signaling 2.962861e-01 0.528
R-HSA-186763 Downstream signal transduction 3.031292e-01 0.518
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 3.031292e-01 0.518
R-HSA-111885 Opioid Signalling 3.088901e-01 0.510
R-HSA-9860931 Response of endothelial cells to shear stress 3.088901e-01 0.510
R-HSA-9711123 Cellular response to chemical stress 3.094320e-01 0.509
R-HSA-9675126 Diseases of mitotic cell cycle 3.099062e-01 0.509
R-HSA-69190 DNA strand elongation 3.099062e-01 0.509
R-HSA-8931838 DAG1 glycosylations 3.099062e-01 0.509
R-HSA-73894 DNA Repair 3.130322e-01 0.504
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 3.166177e-01 0.499
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 3.166177e-01 0.499
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 3.166177e-01 0.499
R-HSA-176187 Activation of ATR in response to replication stress 3.166177e-01 0.499
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 3.166177e-01 0.499
R-HSA-397795 G-protein beta:gamma signalling 3.166177e-01 0.499
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.166177e-01 0.499
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 3.203508e-01 0.494
R-HSA-69239 Synthesis of DNA 3.231643e-01 0.491
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 3.231643e-01 0.491
R-HSA-9700206 Signaling by ALK in cancer 3.231643e-01 0.491
R-HSA-390522 Striated Muscle Contraction 3.232644e-01 0.490
R-HSA-5693537 Resolution of D-Loop Structures 3.232644e-01 0.490
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 3.232644e-01 0.490
R-HSA-5673000 RAF activation 3.298468e-01 0.482
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 3.298468e-01 0.482
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 3.298468e-01 0.482
R-HSA-5205647 Mitophagy 3.298468e-01 0.482
R-HSA-168638 NOD1/2 Signaling Pathway 3.298468e-01 0.482
R-HSA-69002 DNA Replication Pre-Initiation 3.302749e-01 0.481
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 3.302749e-01 0.481
R-HSA-202403 TCR signaling 3.338226e-01 0.476
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 3.363656e-01 0.473
R-HSA-9658195 Leishmania infection 3.379897e-01 0.471
R-HSA-9824443 Parasitic Infection Pathways 3.379897e-01 0.471
R-HSA-432720 Lysosome Vesicle Biogenesis 3.428214e-01 0.465
R-HSA-9682385 FLT3 signaling in disease 3.428214e-01 0.465
R-HSA-3371511 HSF1 activation 3.428214e-01 0.465
R-HSA-111933 Calmodulin induced events 3.428214e-01 0.465
R-HSA-111997 CaM pathway 3.428214e-01 0.465
R-HSA-8853659 RET signaling 3.428214e-01 0.465
R-HSA-6804757 Regulation of TP53 Degradation 3.428214e-01 0.465
R-HSA-1280218 Adaptive Immune System 3.473624e-01 0.459
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 3.479580e-01 0.458
R-HSA-9855142 Cellular responses to mechanical stimuli 3.479580e-01 0.458
R-HSA-933541 TRAF6 mediated IRF7 activation 3.492147e-01 0.457
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.492147e-01 0.457
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.492147e-01 0.457
R-HSA-419037 NCAM1 interactions 3.492147e-01 0.457
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 3.492147e-01 0.457
R-HSA-8948216 Collagen chain trimerization 3.492147e-01 0.457
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 3.555463e-01 0.449
R-HSA-8875878 MET promotes cell motility 3.555463e-01 0.449
R-HSA-74217 Purine salvage 3.555463e-01 0.449
R-HSA-389948 Co-inhibition by PD-1 3.601086e-01 0.444
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 3.618167e-01 0.442
R-HSA-6806003 Regulation of TP53 Expression and Degradation 3.618167e-01 0.442
R-HSA-1266738 Developmental Biology 3.642252e-01 0.439
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 3.680264e-01 0.434
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 3.680264e-01 0.434
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 3.680264e-01 0.434
R-HSA-167169 HIV Transcription Elongation 3.680264e-01 0.434
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.680264e-01 0.434
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 3.680264e-01 0.434
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 3.680264e-01 0.434
R-HSA-9604323 Negative regulation of NOTCH4 signaling 3.680264e-01 0.434
R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi 3.680264e-01 0.434
R-HSA-5693538 Homology Directed Repair 3.689707e-01 0.433
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 3.741761e-01 0.427
R-HSA-5218920 VEGFR2 mediated vascular permeability 3.741761e-01 0.427
R-HSA-9694548 Maturation of spike protein 3.741761e-01 0.427
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 3.741761e-01 0.427
R-HSA-195721 Signaling by WNT 3.754710e-01 0.425
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.793797e-01 0.421
R-HSA-167161 HIV Transcription Initiation 3.802663e-01 0.420
R-HSA-75953 RNA Polymerase II Transcription Initiation 3.802663e-01 0.420
R-HSA-9656223 Signaling by RAF1 mutants 3.802663e-01 0.420
R-HSA-5674135 MAP2K and MAPK activation 3.802663e-01 0.420
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 3.802663e-01 0.420
R-HSA-6811438 Intra-Golgi traffic 3.802663e-01 0.420
R-HSA-5675221 Negative regulation of MAPK pathway 3.802663e-01 0.420
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.862795e-01 0.413
R-HSA-73762 RNA Polymerase I Transcription Initiation 3.862976e-01 0.413
R-HSA-165159 MTOR signalling 3.862976e-01 0.413
R-HSA-111996 Ca-dependent events 3.862976e-01 0.413
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 3.862976e-01 0.413
R-HSA-379716 Cytosolic tRNA aminoacylation 3.862976e-01 0.413
R-HSA-73776 RNA Polymerase II Promoter Escape 3.922706e-01 0.406
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 3.922706e-01 0.406
R-HSA-8854214 TBC/RABGAPs 3.922706e-01 0.406
R-HSA-1433557 Signaling by SCF-KIT 3.922706e-01 0.406
R-HSA-69206 G1/S Transition 3.965667e-01 0.402
R-HSA-9907900 Proteasome assembly 3.981859e-01 0.400
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 4.040439e-01 0.394
R-HSA-1489509 DAG and IP3 signaling 4.040439e-01 0.394
R-HSA-187037 Signaling by NTRK1 (TRKA) 4.067749e-01 0.391
R-HSA-9649948 Signaling downstream of RAS mutants 4.098453e-01 0.387
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 4.098453e-01 0.387
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 4.098453e-01 0.387
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 4.098453e-01 0.387
R-HSA-6802949 Signaling by RAS mutants 4.098453e-01 0.387
R-HSA-9675135 Diseases of DNA repair 4.098453e-01 0.387
R-HSA-9839373 Signaling by TGFBR3 4.098453e-01 0.387
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 4.098453e-01 0.387
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 4.155905e-01 0.381
R-HSA-1474165 Reproduction 4.169003e-01 0.380
R-HSA-9843745 Adipogenesis 4.202563e-01 0.376
R-HSA-389356 Co-stimulation by CD28 4.212802e-01 0.375
R-HSA-1852241 Organelle biogenesis and maintenance 4.236908e-01 0.373
R-HSA-157858 Gap junction trafficking and regulation 4.269148e-01 0.370
R-HSA-9748787 Azathioprine ADME 4.324949e-01 0.364
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 4.324949e-01 0.364
R-HSA-912446 Meiotic recombination 4.380210e-01 0.359
R-HSA-2514856 The phototransduction cascade 4.380210e-01 0.359
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 4.434937e-01 0.353
R-HSA-112382 Formation of RNA Pol II elongation complex 4.434937e-01 0.353
R-HSA-68949 Orc1 removal from chromatin 4.434937e-01 0.353
R-HSA-6794361 Neurexins and neuroligins 4.434937e-01 0.353
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 4.489133e-01 0.348
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 4.489133e-01 0.348
R-HSA-75955 RNA Polymerase II Transcription Elongation 4.489133e-01 0.348
R-HSA-9639288 Amino acids regulate mTORC1 4.489133e-01 0.348
R-HSA-8948751 Regulation of PTEN stability and activity 4.489133e-01 0.348
R-HSA-6807070 PTEN Regulation 4.500072e-01 0.347
R-HSA-9664417 Leishmania phagocytosis 4.532603e-01 0.344
R-HSA-9664407 Parasite infection 4.532603e-01 0.344
R-HSA-9664422 FCGR3A-mediated phagocytosis 4.532603e-01 0.344
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 4.542806e-01 0.343
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 4.565026e-01 0.341
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 4.595959e-01 0.338
R-HSA-3214815 HDACs deacetylate histones 4.595959e-01 0.338
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 4.648597e-01 0.333
R-HSA-193648 NRAGE signals death through JNK 4.648597e-01 0.333
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 4.648597e-01 0.333
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 4.648597e-01 0.333
R-HSA-2871837 FCERI mediated NF-kB activation 4.693610e-01 0.328
R-HSA-453279 Mitotic G1 phase and G1/S transition 4.757226e-01 0.323
R-HSA-422475 Axon guidance 4.758074e-01 0.323
R-HSA-9033241 Peroxisomal protein import 4.803475e-01 0.318
R-HSA-186712 Regulation of beta-cell development 4.803475e-01 0.318
R-HSA-9758941 Gastrulation 4.851785e-01 0.314
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 4.854105e-01 0.314
R-HSA-8943724 Regulation of PTEN gene transcription 4.854105e-01 0.314
R-HSA-1660661 Sphingolipid de novo biosynthesis 4.854105e-01 0.314
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 4.854105e-01 0.314
R-HSA-379724 tRNA Aminoacylation 4.854105e-01 0.314
R-HSA-9679191 Potential therapeutics for SARS 4.883071e-01 0.311
R-HSA-450294 MAP kinase activation 4.904245e-01 0.309
R-HSA-112043 PLC beta mediated events 4.904245e-01 0.309
R-HSA-8956321 Nucleotide salvage 4.904245e-01 0.309
R-HSA-1442490 Collagen degradation 4.904245e-01 0.309
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 4.953899e-01 0.305
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.953899e-01 0.305
R-HSA-375165 NCAM signaling for neurite out-growth 4.953899e-01 0.305
R-HSA-6790901 rRNA modification in the nucleus and cytosol 5.003072e-01 0.301
R-HSA-373755 Semaphorin interactions 5.003072e-01 0.301
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 5.007031e-01 0.300
R-HSA-5688426 Deubiquitination 5.031976e-01 0.298
R-HSA-392499 Metabolism of proteins 5.066534e-01 0.295
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.099995e-01 0.292
R-HSA-9006931 Signaling by Nuclear Receptors 5.147839e-01 0.288
R-HSA-5685942 HDR through Homologous Recombination (HRR) 5.195050e-01 0.284
R-HSA-112040 G-protein mediated events 5.195050e-01 0.284
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 5.241887e-01 0.281
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 5.241887e-01 0.281
R-HSA-5218859 Regulated Necrosis 5.241887e-01 0.281
R-HSA-9840310 Glycosphingolipid catabolism 5.334207e-01 0.273
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 5.334207e-01 0.273
R-HSA-75105 Fatty acyl-CoA biosynthesis 5.334207e-01 0.273
R-HSA-448424 Interleukin-17 signaling 5.334207e-01 0.273
R-HSA-9764560 Regulation of CDH1 Gene Transcription 5.334207e-01 0.273
R-HSA-69202 Cyclin E associated events during G1/S transition 5.334207e-01 0.273
R-HSA-9675108 Nervous system development 5.374605e-01 0.270
R-HSA-453276 Regulation of mitotic cell cycle 5.379696e-01 0.269
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 5.379696e-01 0.269
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.379696e-01 0.269
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 5.379696e-01 0.269
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 5.424746e-01 0.266
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 5.424746e-01 0.266
R-HSA-4086398 Ca2+ pathway 5.469358e-01 0.262
R-HSA-9013694 Signaling by NOTCH4 5.513539e-01 0.259
R-HSA-1222556 ROS and RNS production in phagocytes 5.513539e-01 0.259
R-HSA-1236394 Signaling by ERBB4 5.513539e-01 0.259
R-HSA-983169 Class I MHC mediated antigen processing & presentation 5.568692e-01 0.254
R-HSA-73854 RNA Polymerase I Promoter Clearance 5.600619e-01 0.252
R-HSA-5689603 UCH proteinases 5.600619e-01 0.252
R-HSA-168249 Innate Immune System 5.601672e-01 0.252
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 5.625515e-01 0.250
R-HSA-9694635 Translation of Structural Proteins 5.643528e-01 0.248
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 5.662839e-01 0.247
R-HSA-73864 RNA Polymerase I Transcription 5.686021e-01 0.245
R-HSA-416482 G alpha (12/13) signalling events 5.686021e-01 0.245
R-HSA-216083 Integrin cell surface interactions 5.686021e-01 0.245
R-HSA-9659379 Sensory processing of sound 5.728101e-01 0.242
R-HSA-9833482 PKR-mediated signaling 5.769774e-01 0.239
R-HSA-6806834 Signaling by MET 5.769774e-01 0.239
R-HSA-5673001 RAF/MAP kinase cascade 5.818320e-01 0.235
R-HSA-1483257 Phospholipid metabolism 5.948786e-01 0.226
R-HSA-375276 Peptide ligand-binding receptors 5.953739e-01 0.225
R-HSA-5684996 MAPK1/MAPK3 signaling 5.970275e-01 0.224
R-HSA-6802957 Oncogenic MAPK signaling 5.972156e-01 0.224
R-HSA-6794362 Protein-protein interactions at synapses 5.972156e-01 0.224
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 6.011463e-01 0.221
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 6.110867e-01 0.214
R-HSA-9663891 Selective autophagy 6.127111e-01 0.213
R-HSA-9645723 Diseases of programmed cell death 6.127111e-01 0.213
R-HSA-1236974 ER-Phagosome pathway 6.164915e-01 0.210
R-HSA-1912408 Pre-NOTCH Transcription and Translation 6.239426e-01 0.205
R-HSA-2682334 EPH-Ephrin signaling 6.312499e-01 0.200
R-HSA-9772573 Late SARS-CoV-2 Infection Events 6.312499e-01 0.200
R-HSA-428157 Sphingolipid metabolism 6.337836e-01 0.198
R-HSA-948021 Transport to the Golgi and subsequent modification 6.362411e-01 0.196
R-HSA-5668914 Diseases of metabolism 6.383264e-01 0.195
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 6.386857e-01 0.195
R-HSA-6807878 COPI-mediated anterograde transport 6.489067e-01 0.188
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 6.489067e-01 0.188
R-HSA-212165 Epigenetic regulation of gene expression 6.522207e-01 0.186
R-HSA-422356 Regulation of insulin secretion 6.557318e-01 0.183
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 6.624305e-01 0.179
R-HSA-9009391 Extra-nuclear estrogen signaling 6.657231e-01 0.177
R-HSA-9842860 Regulation of endogenous retroelements 6.689891e-01 0.175
R-HSA-2559580 Oxidative Stress Induced Senescence 6.689891e-01 0.175
R-HSA-1236975 Antigen processing-Cross presentation 6.909800e-01 0.161
R-HSA-1912422 Pre-NOTCH Expression and Processing 7.057930e-01 0.151
R-HSA-15869 Metabolism of nucleotides 7.143298e-01 0.146
R-HSA-8939211 ESR-mediated signaling 7.163408e-01 0.145
R-HSA-157118 Signaling by NOTCH 7.223032e-01 0.141
R-HSA-9759194 Nuclear events mediated by NFE2L2 7.333352e-01 0.135
R-HSA-1660662 Glycosphingolipid metabolism 7.385280e-01 0.132
R-HSA-421270 Cell-cell junction organization 7.432727e-01 0.129
R-HSA-1474228 Degradation of the extracellular matrix 7.653436e-01 0.116
R-HSA-9018519 Estrogen-dependent gene expression 7.766112e-01 0.110
R-HSA-5173105 O-linked glycosylation 7.787993e-01 0.109
R-HSA-1632852 Macroautophagy 7.873410e-01 0.104
R-HSA-418594 G alpha (i) signalling events 7.900645e-01 0.102
R-HSA-388396 GPCR downstream signalling 7.918433e-01 0.101
R-HSA-8856828 Clathrin-mediated endocytosis 7.935315e-01 0.100
R-HSA-199977 ER to Golgi Anterograde Transport 8.015077e-01 0.096
R-HSA-2187338 Visual phototransduction 8.015077e-01 0.096
R-HSA-2142753 Arachidonate metabolism 8.110487e-01 0.091
R-HSA-9609507 Protein localization 8.129015e-01 0.090
R-HSA-9612973 Autophagy 8.183523e-01 0.087
R-HSA-9711097 Cellular response to starvation 8.218982e-01 0.085
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 8.433278e-01 0.074
R-HSA-5689880 Ub-specific processing proteases 8.478972e-01 0.072
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 8.478972e-01 0.072
R-HSA-9764265 Regulation of CDH1 Expression and Function 8.478972e-01 0.072
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 8.478972e-01 0.072
R-HSA-9664433 Leishmania parasite growth and survival 8.478972e-01 0.072
R-HSA-112315 Transmission across Chemical Synapses 8.496579e-01 0.071
R-HSA-8957322 Metabolism of steroids 8.508052e-01 0.070
R-HSA-112316 Neuronal System 8.584558e-01 0.066
R-HSA-372790 Signaling by GPCR 8.621284e-01 0.064
R-HSA-201681 TCF dependent signaling in response to WNT 8.621933e-01 0.064
R-HSA-3781865 Diseases of glycosylation 8.635473e-01 0.064
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.688324e-01 0.061
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 8.787999e-01 0.056
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 8.834977e-01 0.054
R-HSA-397014 Muscle contraction 8.975511e-01 0.047
R-HSA-418990 Adherens junctions interactions 9.034560e-01 0.044
R-HSA-9748784 Drug ADME 9.034560e-01 0.044
R-HSA-8951664 Neddylation 9.062803e-01 0.043
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 9.142700e-01 0.039
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.145291e-01 0.039
R-HSA-72312 rRNA processing 9.159515e-01 0.038
R-HSA-8978868 Fatty acid metabolism 9.230136e-01 0.035
R-HSA-446203 Asparagine N-linked glycosylation 9.318221e-01 0.031
R-HSA-416476 G alpha (q) signalling events 9.388015e-01 0.027
R-HSA-211945 Phase I - Functionalization of compounds 9.467438e-01 0.024
R-HSA-6798695 Neutrophil degranulation 9.488288e-01 0.023
R-HSA-556833 Metabolism of lipids 9.634970e-01 0.016
R-HSA-196854 Metabolism of vitamins and cofactors 9.773877e-01 0.010
R-HSA-500792 GPCR ligand binding 9.832843e-01 0.007
R-HSA-72766 Translation 9.883197e-01 0.005
R-HSA-211859 Biological oxidations 9.954631e-01 0.002
R-HSA-1430728 Metabolism 9.997261e-01 0.000
R-HSA-9709957 Sensory Perception 9.999593e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.836 0.109 2 0.761
CDC7CDC7 0.833 0.131 1 0.877
DSTYKDSTYK 0.832 0.138 2 0.785
IKKBIKKB 0.830 0.083 -2 0.700
CLK3CLK3 0.829 0.136 1 0.832
BMPR1BBMPR1B 0.826 0.244 1 0.820
PIM3PIM3 0.826 0.074 -3 0.862
MOSMOS 0.825 0.086 1 0.889
GRK6GRK6 0.825 0.176 1 0.866
ALK2ALK2 0.824 0.272 -2 0.814
ERK5ERK5 0.824 0.147 1 0.825
RAF1RAF1 0.823 0.038 1 0.830
TGFBR1TGFBR1 0.823 0.194 -2 0.799
CAMK1BCAMK1B 0.821 0.050 -3 0.887
PRPKPRPK 0.821 -0.071 -1 0.685
BMPR1ABMPR1A 0.820 0.258 1 0.810
RSK2RSK2 0.820 0.085 -3 0.808
CAMK2GCAMK2G 0.820 0.010 2 0.670
BMPR2BMPR2 0.820 0.049 -2 0.828
GCN2GCN2 0.819 -0.054 2 0.659
IKKAIKKA 0.819 0.064 -2 0.685
CAMK2BCAMK2B 0.818 0.097 2 0.657
TGFBR2TGFBR2 0.818 0.056 -2 0.817
FAM20CFAM20C 0.818 0.064 2 0.517
IKKEIKKE 0.818 -0.012 1 0.730
TBK1TBK1 0.817 -0.049 1 0.736
ALK4ALK4 0.817 0.166 -2 0.820
NLKNLK 0.817 0.055 1 0.798
ACVR2BACVR2B 0.816 0.191 -2 0.808
NEK6NEK6 0.816 -0.028 -2 0.821
PIM1PIM1 0.816 0.079 -3 0.814
ATRATR 0.816 0.020 1 0.825
ACVR2AACVR2A 0.815 0.158 -2 0.804
MAPKAPK2MAPKAPK2 0.815 0.100 -3 0.760
ATMATM 0.815 0.084 1 0.779
NDR2NDR2 0.815 -0.011 -3 0.867
PRKD1PRKD1 0.815 0.039 -3 0.832
P90RSKP90RSK 0.814 0.050 -3 0.810
NEK7NEK7 0.814 -0.050 -3 0.817
GRK5GRK5 0.814 -0.026 -3 0.848
PDHK4PDHK4 0.814 -0.176 1 0.835
CAMLCKCAMLCK 0.814 0.062 -2 0.797
GRK1GRK1 0.813 0.060 -2 0.688
MTORMTOR 0.813 -0.080 1 0.776
SKMLCKSKMLCK 0.813 0.068 -2 0.767
PLK1PLK1 0.812 0.063 -2 0.816
PKN3PKN3 0.812 -0.007 -3 0.856
HUNKHUNK 0.811 -0.024 2 0.690
DAPK2DAPK2 0.811 0.050 -3 0.882
PRKD2PRKD2 0.811 0.061 -3 0.803
GRK4GRK4 0.811 0.001 -2 0.742
ULK2ULK2 0.811 -0.156 2 0.642
NIKNIK 0.810 -0.032 -3 0.897
CDKL1CDKL1 0.810 0.009 -3 0.822
CAMK2DCAMK2D 0.810 0.000 -3 0.845
PLK3PLK3 0.810 0.085 2 0.651
NUAK2NUAK2 0.810 0.017 -3 0.873
P70S6KBP70S6KB 0.810 0.034 -3 0.829
MAPKAPK3MAPKAPK3 0.809 0.044 -3 0.794
GRK7GRK7 0.809 0.098 1 0.824
RSK3RSK3 0.808 0.032 -3 0.801
PDHK1PDHK1 0.808 -0.172 1 0.825
MLK1MLK1 0.808 -0.057 2 0.719
CAMK2ACAMK2A 0.808 0.061 2 0.687
NDR1NDR1 0.807 -0.026 -3 0.864
KISKIS 0.807 0.025 1 0.673
MSK1MSK1 0.806 0.091 -3 0.764
DLKDLK 0.805 -0.025 1 0.818
CLK4CLK4 0.805 0.092 -3 0.813
CDKL5CDKL5 0.804 0.009 -3 0.812
AURCAURC 0.804 0.056 -2 0.651
LATS2LATS2 0.804 -0.023 -5 0.695
RSK4RSK4 0.804 0.070 -3 0.790
CLK2CLK2 0.804 0.151 -3 0.799
SMG1SMG1 0.804 0.162 1 0.770
MARK4MARK4 0.804 -0.060 4 0.788
LATS1LATS1 0.804 0.038 -3 0.876
CAMK4CAMK4 0.804 0.010 -3 0.852
RIPK3RIPK3 0.804 -0.053 3 0.715
NEK9NEK9 0.804 -0.074 2 0.698
AURAAURA 0.804 0.083 -2 0.637
MSK2MSK2 0.803 0.030 -3 0.755
MST4MST4 0.803 -0.055 2 0.762
MYLK4MYLK4 0.803 0.098 -2 0.728
ULK1ULK1 0.803 -0.149 -3 0.804
TSSK2TSSK2 0.803 -0.002 -5 0.793
PKACGPKACG 0.802 0.002 -2 0.707
CHAK2CHAK2 0.801 -0.089 -1 0.648
AMPKA1AMPKA1 0.801 -0.055 -3 0.874
PKCDPKCD 0.801 -0.027 2 0.694
WNK1WNK1 0.801 -0.075 -2 0.752
ANKRD3ANKRD3 0.801 -0.105 1 0.840
PKACBPKACB 0.800 0.074 -2 0.664
PKN2PKN2 0.800 -0.030 -3 0.862
CHK1CHK1 0.800 0.043 -3 0.845
MEK1MEK1 0.799 -0.009 2 0.716
JNK2JNK2 0.799 0.080 1 0.583
AURBAURB 0.798 0.049 -2 0.654
MASTLMASTL 0.798 -0.191 -2 0.732
ICKICK 0.798 -0.042 -3 0.854
CLK1CLK1 0.798 0.073 -3 0.799
YSK4YSK4 0.798 -0.032 1 0.758
TSSK1TSSK1 0.798 -0.027 -3 0.890
BCKDKBCKDK 0.798 -0.161 -1 0.610
PKRPKR 0.797 -0.028 1 0.812
JNK3JNK3 0.797 0.059 1 0.630
DRAK1DRAK1 0.797 0.064 1 0.737
PRKD3PRKD3 0.797 0.030 -3 0.782
TTBK2TTBK2 0.797 -0.118 2 0.552
WNK3WNK3 0.796 -0.180 1 0.799
PAK1PAK1 0.796 0.000 -2 0.713
NIM1NIM1 0.796 -0.084 3 0.817
AMPKA2AMPKA2 0.796 -0.037 -3 0.851
DNAPKDNAPK 0.796 0.036 1 0.694
SRPK1SRPK1 0.796 -0.004 -3 0.781
MLK3MLK3 0.796 -0.051 2 0.670
PRKXPRKX 0.795 0.083 -3 0.742
MLK2MLK2 0.795 -0.137 2 0.702
HIPK4HIPK4 0.795 -0.050 1 0.730
TLK2TLK2 0.795 -0.035 1 0.770
PAK6PAK6 0.795 0.049 -2 0.691
PERKPERK 0.794 -0.029 -2 0.825
DYRK2DYRK2 0.793 0.015 1 0.657
PAK3PAK3 0.792 -0.033 -2 0.718
PLK2PLK2 0.792 0.090 -3 0.806
MELKMELK 0.792 -0.038 -3 0.837
MNK2MNK2 0.792 -0.020 -2 0.744
BRAFBRAF 0.792 -0.025 -4 0.785
PIM2PIM2 0.792 0.037 -3 0.785
P38BP38B 0.792 0.037 1 0.632
NUAK1NUAK1 0.792 -0.044 -3 0.833
PAK2PAK2 0.791 -0.015 -2 0.709
MLK4MLK4 0.791 -0.073 2 0.634
CDK8CDK8 0.791 -0.044 1 0.627
P38AP38A 0.790 0.020 1 0.688
RIPK1RIPK1 0.790 -0.157 1 0.785
QSKQSK 0.790 -0.042 4 0.757
PASKPASK 0.790 0.080 -3 0.866
PKG2PKG2 0.789 0.023 -2 0.662
AKT2AKT2 0.789 0.037 -3 0.733
MARK2MARK2 0.789 -0.044 4 0.700
MAPKAPK5MAPKAPK5 0.789 -0.031 -3 0.719
SRPK2SRPK2 0.788 -0.007 -3 0.708
NEK2NEK2 0.788 -0.125 2 0.683
VRK2VRK2 0.788 -0.193 1 0.854
SIKSIK 0.788 -0.038 -3 0.798
MEKK3MEKK3 0.788 -0.050 1 0.781
GRK2GRK2 0.788 -0.038 -2 0.651
CK2A2CK2A2 0.788 0.102 1 0.708
BRSK1BRSK1 0.787 -0.038 -3 0.824
MNK1MNK1 0.787 -0.018 -2 0.756
PKACAPKACA 0.787 0.062 -2 0.627
QIKQIK 0.787 -0.103 -3 0.849
P38DP38D 0.787 0.061 1 0.535
MARK3MARK3 0.786 -0.034 4 0.715
HRIHRI 0.786 -0.099 -2 0.817
SRPK3SRPK3 0.786 -0.023 -3 0.751
PKCBPKCB 0.786 -0.067 2 0.667
DCAMKL1DCAMKL1 0.786 -0.011 -3 0.829
TLK1TLK1 0.786 -0.045 -2 0.783
ERK2ERK2 0.786 -0.003 1 0.646
PHKG1PHKG1 0.785 -0.083 -3 0.850
SGK3SGK3 0.785 -0.005 -3 0.792
CAMKK1CAMKK1 0.785 0.049 -2 0.769
DYRK4DYRK4 0.785 0.065 1 0.585
PKCAPKCA 0.784 -0.072 2 0.658
ERK1ERK1 0.784 -0.004 1 0.606
CDK1CDK1 0.784 -0.012 1 0.600
CDK7CDK7 0.784 -0.053 1 0.640
CDK19CDK19 0.784 -0.044 1 0.587
MARK1MARK1 0.784 -0.045 4 0.739
PLK4PLK4 0.784 -0.111 2 0.498
GAKGAK 0.783 0.101 1 0.852
P70S6KP70S6K 0.783 0.002 -3 0.735
CAMK1DCAMK1D 0.783 0.032 -3 0.732
NEK5NEK5 0.783 -0.064 1 0.818
IRE1IRE1 0.783 -0.187 1 0.760
PKCHPKCH 0.783 -0.084 2 0.639
PKCGPKCG 0.783 -0.089 2 0.665
P38GP38G 0.782 0.003 1 0.518
SMMLCKSMMLCK 0.782 0.015 -3 0.843
PINK1PINK1 0.782 -0.092 1 0.779
IRE2IRE2 0.782 -0.155 2 0.623
DCAMKL2DCAMKL2 0.782 -0.013 -3 0.855
CAMK1GCAMK1G 0.781 -0.029 -3 0.795
BRSK2BRSK2 0.781 -0.089 -3 0.840
DAPK3DAPK3 0.781 0.054 -3 0.837
PRP4PRP4 0.780 -0.001 -3 0.773
MEKK2MEKK2 0.780 -0.109 2 0.676
NEK8NEK8 0.780 -0.054 2 0.698
CDK2CDK2 0.780 -0.035 1 0.700
PKCZPKCZ 0.780 -0.121 2 0.669
CDK13CDK13 0.780 -0.058 1 0.618
MEKK1MEKK1 0.780 -0.166 1 0.801
GRK3GRK3 0.779 -0.023 -2 0.609
MEK5MEK5 0.779 -0.195 2 0.701
CHAK1CHAK1 0.779 -0.182 2 0.625
ZAKZAK 0.779 -0.153 1 0.766
TTBK1TTBK1 0.778 -0.077 2 0.484
SNRKSNRK 0.778 -0.140 2 0.560
CK2A1CK2A1 0.778 0.087 1 0.679
CAMKK2CAMKK2 0.778 0.002 -2 0.765
AKT1AKT1 0.778 0.032 -3 0.749
JNK1JNK1 0.778 0.053 1 0.584
ERK7ERK7 0.778 0.012 2 0.494
TAO3TAO3 0.778 -0.074 1 0.777
GSK3BGSK3B 0.777 0.003 4 0.491
DAPK1DAPK1 0.777 0.061 -3 0.817
CDK5CDK5 0.777 -0.050 1 0.665
GSK3AGSK3A 0.776 0.012 4 0.501
DYRK1ADYRK1A 0.775 -0.027 1 0.701
HIPK1HIPK1 0.775 -0.029 1 0.672
TAK1TAK1 0.775 0.068 1 0.791
CDK18CDK18 0.775 -0.046 1 0.579
CDK9CDK9 0.775 -0.058 1 0.625
DYRK3DYRK3 0.775 0.018 1 0.669
MST3MST3 0.775 -0.069 2 0.757
MST2MST2 0.774 -0.039 1 0.798
PHKG2PHKG2 0.773 -0.062 -3 0.847
PAK5PAK5 0.773 0.005 -2 0.620
DYRK1BDYRK1B 0.773 -0.013 1 0.626
HIPK2HIPK2 0.773 -0.021 1 0.562
CDK14CDK14 0.772 -0.020 1 0.621
EEF2KEEF2K 0.772 -0.040 3 0.765
MRCKAMRCKA 0.772 0.053 -3 0.797
CDK17CDK17 0.772 -0.046 1 0.527
WNK4WNK4 0.772 -0.177 -2 0.745
LKB1LKB1 0.772 -0.038 -3 0.816
CDK12CDK12 0.771 -0.063 1 0.589
SSTKSSTK 0.770 -0.090 4 0.751
TAO2TAO2 0.770 -0.100 2 0.729
PKCTPKCT 0.769 -0.091 2 0.642
CHK2CHK2 0.769 0.032 -3 0.685
PAK4PAK4 0.769 0.002 -2 0.631
HIPK3HIPK3 0.768 -0.054 1 0.681
IRAK4IRAK4 0.768 -0.171 1 0.776
CDK3CDK3 0.768 -0.015 1 0.549
MRCKBMRCKB 0.767 0.040 -3 0.783
CAMK1ACAMK1A 0.767 0.017 -3 0.706
NEK4NEK4 0.767 -0.110 1 0.767
NEK11NEK11 0.767 -0.172 1 0.772
CDK16CDK16 0.766 -0.028 1 0.551
SGK1SGK1 0.766 0.026 -3 0.650
GCKGCK 0.766 -0.056 1 0.764
PDK1PDK1 0.766 -0.102 1 0.783
NEK1NEK1 0.766 -0.058 1 0.790
CK1ECK1E 0.765 -0.083 -3 0.529
IRAK1IRAK1 0.765 -0.194 -1 0.604
PKCIPKCI 0.765 -0.090 2 0.652
BUB1BUB1 0.764 0.047 -5 0.777
MEK2MEK2 0.764 -0.113 2 0.663
ALPHAK3ALPHAK3 0.763 0.067 -1 0.625
ROCK2ROCK2 0.763 0.015 -3 0.825
SBKSBK 0.763 0.033 -3 0.616
MST1MST1 0.763 -0.074 1 0.774
VRK1VRK1 0.763 -0.100 2 0.700
AKT3AKT3 0.762 0.017 -3 0.665
LOKLOK 0.761 -0.081 -2 0.715
CDK10CDK10 0.761 -0.030 1 0.602
PKCEPKCE 0.761 -0.050 2 0.652
CK1G1CK1G1 0.760 -0.089 -3 0.538
CK1DCK1D 0.760 -0.066 -3 0.475
PKN1PKN1 0.760 -0.038 -3 0.755
TNIKTNIK 0.760 -0.107 3 0.814
HPK1HPK1 0.760 -0.061 1 0.749
SLKSLK 0.760 -0.073 -2 0.649
RIPK2RIPK2 0.759 -0.132 1 0.722
TTKTTK 0.758 -0.005 -2 0.810
LRRK2LRRK2 0.758 -0.187 2 0.713
MPSK1MPSK1 0.757 -0.133 1 0.754
DMPK1DMPK1 0.757 0.045 -3 0.812
MINKMINK 0.757 -0.151 1 0.761
HGKHGK 0.756 -0.151 3 0.802
CDK4CDK4 0.756 -0.038 1 0.576
CK1A2CK1A2 0.755 -0.077 -3 0.476
MEKK6MEKK6 0.755 -0.201 1 0.793
PBKPBK 0.754 -0.024 1 0.796
MAP3K15MAP3K15 0.754 -0.212 1 0.754
MAKMAK 0.753 -0.011 -2 0.628
PKG1PKG1 0.753 -0.003 -2 0.589
CDK6CDK6 0.753 -0.051 1 0.599
BIKEBIKE 0.752 0.045 1 0.749
KHS2KHS2 0.752 -0.075 1 0.752
ROCK1ROCK1 0.751 0.011 -3 0.795
CRIKCRIK 0.751 0.010 -3 0.739
OSR1OSR1 0.751 -0.078 2 0.691
YSK1YSK1 0.751 -0.145 2 0.693
KHS1KHS1 0.750 -0.114 1 0.752
MOKMOK 0.750 -0.032 1 0.704
STK33STK33 0.749 -0.170 2 0.514
PDHK3_TYRPDHK3_TYR 0.749 0.159 4 0.871
NEK3NEK3 0.745 -0.191 1 0.749
YANK3YANK3 0.744 -0.062 2 0.339
MAP2K4_TYRMAP2K4_TYR 0.743 0.076 -1 0.710
MAP2K6_TYRMAP2K6_TYR 0.743 0.112 -1 0.693
PDHK4_TYRPDHK4_TYR 0.742 0.116 2 0.767
TXKTXK 0.740 0.215 1 0.847
EPHB4EPHB4 0.739 0.147 -1 0.720
TAO1TAO1 0.738 -0.124 1 0.707
EPHA4EPHA4 0.738 0.156 2 0.683
PDHK1_TYRPDHK1_TYR 0.738 0.039 -1 0.710
SRMSSRMS 0.737 0.213 1 0.897
BMPR2_TYRBMPR2_TYR 0.737 0.013 -1 0.674
EPHA6EPHA6 0.737 0.085 -1 0.703
MYO3BMYO3B 0.736 -0.134 2 0.702
FERFER 0.736 0.109 1 0.916
ASK1ASK1 0.736 -0.183 1 0.747
EPHB1EPHB1 0.736 0.170 1 0.893
MAP2K7_TYRMAP2K7_TYR 0.736 -0.097 2 0.724
TESK1_TYRTESK1_TYR 0.735 -0.107 3 0.887
EPHB3EPHB3 0.735 0.158 -1 0.713
STLK3STLK3 0.734 -0.128 1 0.734
EPHB2EPHB2 0.734 0.165 -1 0.714
AAK1AAK1 0.733 0.059 1 0.652
ABL2ABL2 0.733 0.076 -1 0.694
MYO3AMYO3A 0.732 -0.151 1 0.745
RETRET 0.732 -0.033 1 0.811
HASPINHASPIN 0.732 -0.121 -1 0.507
YES1YES1 0.732 0.101 -1 0.712
PINK1_TYRPINK1_TYR 0.732 -0.124 1 0.833
TECTEC 0.730 0.173 -1 0.693
ITKITK 0.730 0.155 -1 0.691
TYRO3TYRO3 0.730 0.035 3 0.787
BMXBMX 0.728 0.142 -1 0.652
MERTKMERTK 0.728 0.133 3 0.779
HCKHCK 0.728 0.093 -1 0.707
BLKBLK 0.727 0.130 -1 0.700
ABL1ABL1 0.727 0.047 -1 0.693
PKMYT1_TYRPKMYT1_TYR 0.727 -0.218 3 0.850
LCKLCK 0.726 0.093 -1 0.693
FGRFGR 0.726 -0.002 1 0.877
TYK2TYK2 0.726 -0.127 1 0.820
INSRRINSRR 0.725 -0.012 3 0.746
EPHA5EPHA5 0.725 0.143 2 0.670
MST1RMST1R 0.724 -0.086 3 0.798
LIMK2_TYRLIMK2_TYR 0.724 -0.123 -3 0.891
ROS1ROS1 0.724 -0.077 3 0.759
EPHA7EPHA7 0.724 0.096 2 0.671
CSF1RCSF1R 0.723 -0.035 3 0.755
JAK2JAK2 0.723 -0.109 1 0.812
FGFR2FGFR2 0.723 -0.030 3 0.791
DDR1DDR1 0.723 -0.081 4 0.806
BTKBTK 0.723 0.129 -1 0.700
FYNFYN 0.723 0.109 -1 0.653
CK1ACK1A 0.722 -0.094 -3 0.388
TEKTEK 0.721 0.039 3 0.730
AXLAXL 0.721 0.023 3 0.772
FRKFRK 0.721 0.112 -1 0.749
EPHA3EPHA3 0.720 0.043 2 0.643
TNK2TNK2 0.720 0.008 3 0.746
FLT3FLT3 0.720 -0.042 3 0.764
PTK2BPTK2B 0.719 0.088 -1 0.689
KITKIT 0.719 -0.028 3 0.760
JAK3JAK3 0.718 -0.105 1 0.790
PTK6PTK6 0.718 -0.041 -1 0.631
LTKLTK 0.718 -0.001 3 0.731
NTRK1NTRK1 0.717 -0.045 -1 0.669
LIMK1_TYRLIMK1_TYR 0.717 -0.269 2 0.703
FGFR3FGFR3 0.716 -0.007 3 0.765
EPHA8EPHA8 0.716 0.059 -1 0.666
FGFR1FGFR1 0.715 -0.097 3 0.766
LYNLYN 0.715 0.071 3 0.685
CK1G3CK1G3 0.715 -0.060 -3 0.346
FLT1FLT1 0.714 -0.030 -1 0.670
ALKALK 0.714 -0.050 3 0.709
NEK10_TYRNEK10_TYR 0.714 -0.085 1 0.663
EPHA1EPHA1 0.714 0.038 3 0.745
EPHA2EPHA2 0.714 0.087 -1 0.657
SYKSYK 0.713 0.078 -1 0.617
EGFREGFR 0.713 0.025 1 0.740
ERBB2ERBB2 0.713 -0.041 1 0.803
PDGFRBPDGFRB 0.713 -0.161 3 0.780
METMET 0.713 -0.057 3 0.780
KDRKDR 0.712 -0.099 3 0.722
SRCSRC 0.710 0.045 -1 0.665
PTK2PTK2 0.710 0.040 -1 0.609
FGFR4FGFR4 0.710 0.004 -1 0.652
NTRK3NTRK3 0.710 -0.061 -1 0.634
YANK2YANK2 0.709 -0.090 2 0.352
JAK1JAK1 0.709 -0.111 1 0.749
CSKCSK 0.708 -0.024 2 0.658
NTRK2NTRK2 0.707 -0.104 3 0.736
TNK1TNK1 0.707 -0.155 3 0.778
INSRINSR 0.706 -0.096 3 0.729
FLT4FLT4 0.706 -0.104 3 0.723
PDGFRAPDGFRA 0.706 -0.184 3 0.772
MATKMATK 0.705 -0.054 -1 0.612
TNNI3K_TYRTNNI3K_TYR 0.703 -0.164 1 0.798
DDR2DDR2 0.703 -0.046 3 0.718
WEE1_TYRWEE1_TYR 0.701 -0.118 -1 0.618
IGF1RIGF1R 0.700 -0.049 3 0.685
ERBB4ERBB4 0.699 0.022 1 0.765
CK1G2CK1G2 0.698 -0.065 -3 0.447
MUSKMUSK 0.695 -0.066 1 0.743
FESFES 0.691 -0.014 -1 0.616
ZAP70ZAP70 0.686 0.004 -1 0.533