Motif 966 (n=120)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NKT7 | RGPD3 | S1315 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MT19 | RHPN2P1 | S505 | ochoa | Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) | None |
| H0YHG0 | None | S478 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| O14715 | RGPD8 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43148 | RNMT | S21 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43426 | SYNJ1 | S93 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43615 | TIMM44 | S185 | ochoa | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| O60763 | USO1 | S942 | ochoa|psp | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| O60784 | TOM1 | S359 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75390 | CS | S190 | ochoa | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) | Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}. |
| O75914 | PAK3 | S120 | ochoa | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O95747 | OXSR1 | S423 | ochoa | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| P00740 | F9 | S204 | psp | Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain] | Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. {ECO:0000269|PubMed:1730085, ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:8295821}. |
| P02794 | FTH1 | S164 | ochoa | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293). {ECO:0000250|UniProtKB:P09528, ECO:0000269|PubMed:24695223, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:9003196}. |
| P04075 | ALDOA | S272 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05062 | ALDOB | S272 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P08559 | PDHA1 | S239 | psp | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}. |
| P08670 | VIM | S419 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P0DJD0 | RGPD1 | S1002 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD0 | RGPD1 | S1299 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1010 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DJD1 | RGPD2 | S1307 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P12429 | ANXA3 | S149 | ochoa | Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) | Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. |
| P13637 | ATP1A3 | S474 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P28066 | PSMA5 | S63 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P34897 | SHMT2 | S226 | ochoa | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| P35227 | PCGF2 | S251 | ochoa | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) | Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000250|UniProtKB:P23798, ECO:0000269|PubMed:26151332}. |
| P37023 | ACVRL1 | S155 | ochoa | Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I) | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:26176610}. |
| P38398 | BRCA1 | S1457 | ochoa|psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41212 | ETV6 | S321 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P42356 | PI4KA | S1436 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
| P49321 | NASP | S30 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49792 | RANBP2 | S1993 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2290 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50851 | LRBA | S1792 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P62701 | RPS4X | S237 | ochoa | Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P78368 | CSNK1G2 | S366 | ochoa | Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}. |
| P82979 | SARNP | S165 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| P98174 | FGD1 | S703 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q00610 | CLTC | S1462 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q00987 | MDM2 | S157 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q05655 | PRKCD | S130 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q06418 | TYRO3 | S466 | ochoa | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}. |
| Q09028 | RBBP4 | S348 | ochoa | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q12769 | NUP160 | S1147 | ochoa | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport. {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}. |
| Q12879 | GRIN2A | S929 | psp | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q12888 | TP53BP1 | S523 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13464 | ROCK1 | S1105 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13813 | SPTAN1 | S2138 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13895 | BYSL | S170 | ochoa | Bystin | Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}. |
| Q14202 | ZMYM3 | S960 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14966 | ZNF638 | S585 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15075 | EEA1 | S49 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15361 | TTF1 | S472 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15545 | TAF7 | S34 | ochoa | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q15906 | VPS72 | S108 | ochoa | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| Q16576 | RBBP7 | S347 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q2KHM9 | KIAA0753 | S670 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
| Q2LD37 | BLTP1 | S4539 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q52LW3 | ARHGAP29 | S179 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5R3F8 | ELFN2 | S633 | ochoa | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| Q63HN8 | RNF213 | S929 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q6P2E9 | EDC4 | S871 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P2Q9 | PRPF8 | S1355 | ochoa | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:10411133, ECO:0000269|PubMed:11971955, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000303|PubMed:15840809}. |
| Q6PCB5 | RSBN1L | S734 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q7Z2T5 | TRMT1L | S703 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q7Z3J3 | RGPD4 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3J3 | RGPD4 | S1315 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z417 | NUFIP2 | S582 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q86YS7 | C2CD5 | S817 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q8IUC4 | RHPN2 | S608 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8NA72 | POC5 | S73 | ochoa | Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) | Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. |
| Q8NC44 | RETREG2 | S291 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8NEY1 | NAV1 | S387 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NF91 | SYNE1 | S5917 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NF91 | SYNE1 | S8280 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TCU6 | PREX1 | S1191 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TD26 | CHD6 | S1654 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q92547 | TOPBP1 | S1138 | ochoa|psp | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92621 | NUP205 | S1939 | ochoa | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
| Q96L91 | EP400 | S931 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96N11 | INTS15 | S362 | ochoa | Integrator complex subunit 15 | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:36920904, PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:38570683). INTS15 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). Within the integrator complex, INTS15 is required to bridge different integrator modules (PubMed:36920904). {ECO:0000269|PubMed:36920904, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386}. |
| Q99590 | SCAF11 | S626 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99666 | RGPD5 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BUB5 | MKNK1 | S413 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9C0B5 | ZDHHC5 | S455 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9GZY6 | LAT2 | S102 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H2G2 | SLK | S546 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9NRY4 | ARHGAP35 | S773 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NUM4 | TMEM106B | S23 | ochoa | Transmembrane protein 106B | In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:25066864}.; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. {ECO:0000269|PubMed:33333024, ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:37421949}. |
| Q9NUQ6 | SPATS2L | S159 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NVS9 | PNPO | S40 | ochoa | Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491, ECO:0000269|PubMed:15182361, ECO:0000269|PubMed:15772097}. |
| Q9NZ56 | FMN2 | S93 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9NZM3 | ITSN2 | S278 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9UDT6 | CLIP2 | S202 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UDY2 | TJP2 | S325 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHB7 | AFF4 | S310 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UJF2 | RASAL2 | S838 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9ULD2 | MTUS1 | S360 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULJ3 | ZBTB21 | S507 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULJ8 | PPP1R9A | S460 | psp | Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) | Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). {ECO:0000250}. |
| Q9UMZ2 | SYNRG | S730 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9Y230 | RUVBL2 | S220 | ochoa | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| Q9Y2L5 | TRAPPC8 | S273 | ochoa | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
| Q9Y426 | C2CD2 | S519 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y485 | DMXL1 | S425 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| P31327 | CPS1 | S564 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Q13283 | G3BP1 | S362 | Sugiyama | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| O95817 | BAG3 | S467 | Sugiyama | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| Q92626 | PXDN | S908 | Sugiyama | Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] | Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (PubMed:18929642, PubMed:19590037, PubMed:22842973, PubMed:25708780, PubMed:25713063, PubMed:27697841, PubMed:28154175, PubMed:34679700). In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling (PubMed:19590037, PubMed:32543734, PubMed:34679700). Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity (PubMed:32543734). In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways (PubMed:25713063). Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes (PubMed:32571911). In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds (PubMed:28154175). Binds laminins (PubMed:32485152). May play a role in the organization of eyeball structure and lens development during eye development (By similarity). {ECO:0000250|UniProtKB:Q3UQ28, ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:22842973, ECO:0000269|PubMed:25708780, ECO:0000269|PubMed:25713063, ECO:0000269|PubMed:27697841, ECO:0000269|PubMed:28154175, ECO:0000269|PubMed:32485152, ECO:0000269|PubMed:32543734, ECO:0000269|PubMed:32571911, ECO:0000269|PubMed:34679700}. |
| P47756 | CAPZB | S184 | Sugiyama | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| P29401 | TKT | S449 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| Q9UNN4 | GTF2A1L | S418 | SIGNOR|ELM|iPTMNet | TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor) | May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}. |
| P49591 | SARS1 | S394 | Sugiyama | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}. |
| Q9Y617 | PSAT1 | S285 | Sugiyama | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| P33992 | MCM5 | S405 | Sugiyama | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| P31939 | ATIC | S401 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P14625 | HSP90B1 | S655 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P00568 | AK1 | S58 | Sugiyama | Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) (PubMed:21080915, PubMed:23416111, PubMed:2542324). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity). {ECO:0000250|UniProtKB:P05081, ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:2542324}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.000003 | 5.597 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.000003 | 5.564 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000018 | 4.738 |
| R-HSA-75153 | Apoptotic execution phase | 0.000095 | 4.020 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.000128 | 3.891 |
| R-HSA-2262752 | Cellular responses to stress | 0.000938 | 3.028 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.001230 | 2.910 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.002296 | 2.639 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.002256 | 2.647 |
| R-HSA-70171 | Glycolysis | 0.002412 | 2.618 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.003449 | 2.462 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.003722 | 2.429 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.003722 | 2.429 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.004307 | 2.366 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.004307 | 2.366 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.004619 | 2.335 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.004768 | 2.322 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.004569 | 2.340 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.004619 | 2.335 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.004945 | 2.306 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.003243 | 2.489 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.003243 | 2.489 |
| R-HSA-1640170 | Cell Cycle | 0.002942 | 2.531 |
| R-HSA-162587 | HIV Life Cycle | 0.003496 | 2.456 |
| R-HSA-162906 | HIV Infection | 0.004645 | 2.333 |
| R-HSA-70326 | Glucose metabolism | 0.004850 | 2.314 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.002951 | 2.530 |
| R-HSA-109581 | Apoptosis | 0.004005 | 2.397 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.002867 | 2.543 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.003462 | 2.461 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.005284 | 2.277 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.006779 | 2.169 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.007188 | 2.143 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.006868 | 2.163 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.007188 | 2.143 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.006004 | 2.222 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.007024 | 2.153 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.007188 | 2.143 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.007188 | 2.143 |
| R-HSA-69481 | G2/M Checkpoints | 0.006758 | 2.170 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.007024 | 2.153 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.006384 | 2.195 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.006779 | 2.169 |
| R-HSA-168255 | Influenza Infection | 0.006298 | 2.201 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.007326 | 2.135 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.007611 | 2.119 |
| R-HSA-9673218 | Defective F9 secretion | 0.008226 | 2.085 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.008501 | 2.071 |
| R-HSA-9679506 | SARS-CoV Infections | 0.008512 | 2.070 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.008926 | 2.049 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.008926 | 2.049 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.009946 | 2.002 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.010457 | 1.981 |
| R-HSA-5357801 | Programmed Cell Death | 0.011348 | 1.945 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.014849 | 1.828 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.014782 | 1.830 |
| R-HSA-3214847 | HATs acetylate histones | 0.013524 | 1.869 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.013276 | 1.877 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.015822 | 1.801 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.016384 | 1.786 |
| R-HSA-5657560 | Hereditary fructose intolerance | 0.016384 | 1.786 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.016384 | 1.786 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.017088 | 1.767 |
| R-HSA-191859 | snRNP Assembly | 0.018495 | 1.733 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.018495 | 1.733 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.019964 | 1.700 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.017491 | 1.757 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.020015 | 1.699 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.020722 | 1.684 |
| R-HSA-373755 | Semaphorin interactions | 0.021496 | 1.668 |
| R-HSA-9672383 | Defective factor IX causes thrombophilia | 0.032502 | 1.488 |
| R-HSA-9672396 | Defective cofactor function of FVIIIa variant | 0.032502 | 1.488 |
| R-HSA-9673202 | Defective F9 variant does not activate FX | 0.032502 | 1.488 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.034372 | 1.464 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.034372 | 1.464 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.029193 | 1.535 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.031040 | 1.508 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.027543 | 1.560 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.028250 | 1.549 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.029164 | 1.535 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.034372 | 1.464 |
| R-HSA-9609690 | HCMV Early Events | 0.033633 | 1.473 |
| R-HSA-167172 | Transcription of the HIV genome | 0.025600 | 1.592 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.031040 | 1.508 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.029164 | 1.535 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.028150 | 1.551 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.032979 | 1.482 |
| R-HSA-68875 | Mitotic Prophase | 0.025653 | 1.591 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.029193 | 1.535 |
| R-HSA-3371556 | Cellular response to heat stress | 0.026264 | 1.581 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.032002 | 1.495 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.026264 | 1.581 |
| R-HSA-9824446 | Viral Infection Pathways | 0.027823 | 1.556 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.033020 | 1.481 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.034174 | 1.466 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.034978 | 1.456 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.034978 | 1.456 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.034978 | 1.456 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.038093 | 1.419 |
| R-HSA-9673240 | Defective gamma-carboxylation of F9 | 0.040462 | 1.393 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.056188 | 1.250 |
| R-HSA-9673221 | Defective F9 activation | 0.056188 | 1.250 |
| R-HSA-196025 | Formation of annular gap junctions | 0.086876 | 1.061 |
| R-HSA-190873 | Gap junction degradation | 0.094392 | 1.025 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.094392 | 1.025 |
| R-HSA-9668250 | Defective factor IX causes hemophilia B | 0.101847 | 0.992 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.138216 | 0.859 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.152352 | 0.817 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.159333 | 0.798 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.049732 | 1.303 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.058177 | 1.235 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.179935 | 0.745 |
| R-HSA-167161 | HIV Transcription Initiation | 0.062573 | 1.204 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.062573 | 1.204 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.186691 | 0.729 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.186691 | 0.729 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.186691 | 0.729 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.186691 | 0.729 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.186691 | 0.729 |
| R-HSA-72649 | Translation initiation complex formation | 0.093599 | 1.029 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.098704 | 1.006 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.109139 | 0.962 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.182507 | 0.739 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.182507 | 0.739 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.200361 | 0.698 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.203357 | 0.692 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.059606 | 1.225 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.102900 | 0.988 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.071687 | 1.145 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.200036 | 0.699 |
| R-HSA-156902 | Peptide chain elongation | 0.191405 | 0.718 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.045693 | 1.340 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.049732 | 1.303 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.071687 | 1.145 |
| R-HSA-774815 | Nucleosome assembly | 0.071687 | 1.145 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.067078 | 1.173 |
| R-HSA-6798695 | Neutrophil degranulation | 0.102172 | 0.991 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.079298 | 1.101 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.041783 | 1.379 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.062573 | 1.204 |
| R-HSA-1221632 | Meiotic synapsis | 0.091077 | 1.041 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.056022 | 1.252 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.087210 | 1.059 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.083636 | 1.078 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.149001 | 0.827 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.186691 | 0.729 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.091077 | 1.041 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.128049 | 0.893 |
| R-HSA-69541 | Stabilization of p53 | 0.056022 | 1.252 |
| R-HSA-5693538 | Homology Directed Repair | 0.096874 | 1.014 |
| R-HSA-176974 | Unwinding of DNA | 0.094392 | 1.025 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.101847 | 0.992 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.123847 | 0.907 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.131061 | 0.883 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.145313 | 0.838 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.045693 | 1.340 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.049732 | 1.303 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.088575 | 1.053 |
| R-HSA-1268020 | Mitochondrial protein import | 0.114462 | 0.941 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.133586 | 0.874 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.173124 | 0.762 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.137554 | 0.862 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.206359 | 0.685 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.066406 | 1.178 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.168726 | 0.773 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.152352 | 0.817 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.053895 | 1.268 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.173124 | 0.762 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.062573 | 1.204 |
| R-HSA-9766229 | Degradation of CDH1 | 0.081200 | 1.090 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.096141 | 1.017 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.144818 | 0.839 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.173124 | 0.762 |
| R-HSA-1500620 | Meiosis | 0.179555 | 0.746 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.191241 | 0.718 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.081200 | 1.090 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.081200 | 1.090 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.106503 | 0.973 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.058177 | 1.235 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.058177 | 1.235 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.116574 | 0.933 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.045693 | 1.340 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 0.159333 | 0.798 |
| R-HSA-964975 | Vitamin B6 activation to pyridoxal phosphate | 0.159333 | 0.798 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.159333 | 0.798 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.058177 | 1.235 |
| R-HSA-9710421 | Defective pyroptosis | 0.067078 | 1.173 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.074029 | 1.131 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.103885 | 0.983 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.156799 | 0.805 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.078786 | 1.104 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.105245 | 0.978 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.055693 | 1.254 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.128049 | 0.893 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.123847 | 0.907 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.047697 | 1.322 |
| R-HSA-68882 | Mitotic Anaphase | 0.132457 | 0.878 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.072090 | 1.142 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.072090 | 1.142 |
| R-HSA-3928664 | Ephrin signaling | 0.173124 | 0.762 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.117148 | 0.931 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.133911 | 0.873 |
| R-HSA-9671793 | Diseases of hemostasis | 0.179935 | 0.745 |
| R-HSA-428540 | Activation of RAC1 | 0.116574 | 0.933 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.200036 | 0.699 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.101285 | 0.994 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.141992 | 0.848 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.164915 | 0.783 |
| R-HSA-199991 | Membrane Trafficking | 0.051254 | 1.290 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.154837 | 0.810 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.082492 | 1.084 |
| R-HSA-8953854 | Metabolism of RNA | 0.051585 | 1.287 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.193391 | 0.714 |
| R-HSA-9675135 | Diseases of DNA repair | 0.074029 | 1.131 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 0.109241 | 0.962 |
| R-HSA-70350 | Fructose catabolism | 0.152352 | 0.817 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.109139 | 0.962 |
| R-HSA-69206 | G1/S Transition | 0.110400 | 0.957 |
| R-HSA-9609646 | HCMV Infection | 0.074121 | 1.130 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.074029 | 1.131 |
| R-HSA-9843745 | Adipogenesis | 0.122797 | 0.911 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.131061 | 0.883 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.131061 | 0.883 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.093599 | 1.029 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.125302 | 0.902 |
| R-HSA-4086400 | PCP/CE pathway | 0.159122 | 0.798 |
| R-HSA-69242 | S Phase | 0.158768 | 0.799 |
| R-HSA-70268 | Pyruvate metabolism | 0.188433 | 0.725 |
| R-HSA-9659379 | Sensory processing of sound | 0.162014 | 0.790 |
| R-HSA-8964038 | LDL clearance | 0.206628 | 0.685 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.166720 | 0.778 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.094392 | 1.025 |
| R-HSA-9635465 | Suppression of apoptosis | 0.109241 | 0.962 |
| R-HSA-5652084 | Fructose metabolism | 0.206628 | 0.685 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.098704 | 1.006 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.130811 | 0.883 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.136375 | 0.865 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.205949 | 0.686 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.091988 | 1.036 |
| R-HSA-194138 | Signaling by VEGF | 0.110400 | 0.957 |
| R-HSA-140834 | Extrinsic Pathway of Fibrin Clot Formation | 0.048357 | 1.316 |
| R-HSA-9662001 | Defective factor VIII causes hemophilia A | 0.071658 | 1.145 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.152352 | 0.817 |
| R-HSA-977347 | Serine metabolism | 0.200036 | 0.699 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.053156 | 1.274 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.067806 | 1.169 |
| R-HSA-422475 | Axon guidance | 0.097907 | 1.009 |
| R-HSA-9675108 | Nervous system development | 0.127307 | 0.895 |
| R-HSA-159763 | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu... | 0.071658 | 1.145 |
| R-HSA-159782 | Removal of aminoterminal propeptides from gamma-carboxylated proteins | 0.079298 | 1.101 |
| R-HSA-159740 | Gamma-carboxylation of protein precursors | 0.116574 | 0.933 |
| R-HSA-159854 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | 0.123847 | 0.907 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.123847 | 0.907 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.141992 | 0.848 |
| R-HSA-73886 | Chromosome Maintenance | 0.101862 | 0.992 |
| R-HSA-9610379 | HCMV Late Events | 0.176822 | 0.752 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.086876 | 1.061 |
| R-HSA-2028269 | Signaling by Hippo | 0.166257 | 0.779 |
| R-HSA-9629569 | Protein hydroxylation | 0.186691 | 0.729 |
| R-HSA-210991 | Basigin interactions | 0.193391 | 0.714 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.136375 | 0.865 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.179555 | 0.746 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.145313 | 0.838 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.191241 | 0.718 |
| R-HSA-2559583 | Cellular Senescence | 0.083727 | 1.077 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.173124 | 0.762 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.200036 | 0.699 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.051392 | 1.289 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.172722 | 0.763 |
| R-HSA-74160 | Gene expression (Transcription) | 0.094521 | 1.024 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 0.179935 | 0.745 |
| R-HSA-373753 | Nephrin family interactions | 0.186691 | 0.729 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.141992 | 0.848 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.195244 | 0.709 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.075710 | 1.121 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.075710 | 1.121 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.041783 | 1.379 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.109139 | 0.962 |
| R-HSA-6807070 | PTEN Regulation | 0.139440 | 0.856 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.060416 | 1.219 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.181098 | 0.742 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.112826 | 0.948 |
| R-HSA-1266738 | Developmental Biology | 0.086350 | 1.064 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.044410 | 1.353 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.156354 | 0.806 |
| R-HSA-917937 | Iron uptake and transport | 0.150507 | 0.822 |
| R-HSA-70263 | Gluconeogenesis | 0.078786 | 1.104 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.144818 | 0.839 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.045693 | 1.340 |
| R-HSA-4839726 | Chromatin organization | 0.073218 | 1.135 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.103539 | 0.985 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.136375 | 0.865 |
| R-HSA-418990 | Adherens junctions interactions | 0.135371 | 0.868 |
| R-HSA-421270 | Cell-cell junction organization | 0.186927 | 0.728 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.109139 | 0.962 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.060361 | 1.219 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.088575 | 1.053 |
| R-HSA-1500931 | Cell-Cell communication | 0.146468 | 0.834 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.201758 | 0.695 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.191405 | 0.718 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.200361 | 0.698 |
| R-HSA-211000 | Gene Silencing by RNA | 0.076492 | 1.116 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.180359 | 0.744 |
| R-HSA-72306 | tRNA processing | 0.205949 | 0.686 |
| R-HSA-5619102 | SLC transporter disorders | 0.197511 | 0.704 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.170740 | 0.768 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.207078 | 0.684 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.208071 | 0.682 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.209365 | 0.679 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.210199 | 0.677 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.212910 | 0.672 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.213165 | 0.671 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.213165 | 0.671 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.213165 | 0.671 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.215391 | 0.667 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.218410 | 0.661 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.218410 | 0.661 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.219649 | 0.658 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.221433 | 0.655 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.224460 | 0.649 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.226079 | 0.646 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.226079 | 0.646 |
| R-HSA-9620244 | Long-term potentiation | 0.226079 | 0.646 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.230522 | 0.637 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.232458 | 0.634 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.232458 | 0.634 |
| R-HSA-70635 | Urea cycle | 0.232458 | 0.634 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.232458 | 0.634 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.232458 | 0.634 |
| R-HSA-446728 | Cell junction organization | 0.233101 | 0.632 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.233558 | 0.632 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.238784 | 0.622 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.238784 | 0.622 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.238784 | 0.622 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.238784 | 0.622 |
| R-HSA-201451 | Signaling by BMP | 0.238784 | 0.622 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.239636 | 0.620 |
| R-HSA-1483255 | PI Metabolism | 0.239636 | 0.620 |
| R-HSA-68886 | M Phase | 0.241040 | 0.618 |
| R-HSA-192823 | Viral mRNA Translation | 0.242678 | 0.615 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.244832 | 0.611 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.245058 | 0.611 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.245058 | 0.611 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.245722 | 0.610 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.245722 | 0.610 |
| R-HSA-5663205 | Infectious disease | 0.246780 | 0.608 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.251281 | 0.600 |
| R-HSA-72086 | mRNA Capping | 0.251281 | 0.600 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.251281 | 0.600 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.253637 | 0.596 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.254862 | 0.594 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.257453 | 0.589 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.257453 | 0.589 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.257911 | 0.589 |
| R-HSA-69239 | Synthesis of DNA | 0.257911 | 0.589 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.260960 | 0.583 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.260960 | 0.583 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.260960 | 0.583 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.263497 | 0.579 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.263574 | 0.579 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.263574 | 0.579 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.264010 | 0.578 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.264010 | 0.578 |
| R-HSA-202403 | TCR signaling | 0.267060 | 0.573 |
| R-HSA-1538133 | G0 and Early G1 | 0.269646 | 0.569 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.269646 | 0.569 |
| R-HSA-69190 | DNA strand elongation | 0.269646 | 0.569 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.271378 | 0.566 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.273160 | 0.564 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.273160 | 0.564 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.275667 | 0.560 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.275667 | 0.560 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.275667 | 0.560 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.275667 | 0.560 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.275667 | 0.560 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.275836 | 0.559 |
| R-HSA-390522 | Striated Muscle Contraction | 0.281640 | 0.550 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.281640 | 0.550 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.281640 | 0.550 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.281640 | 0.550 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.281640 | 0.550 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.287563 | 0.541 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.287563 | 0.541 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.287563 | 0.541 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.291443 | 0.535 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.291443 | 0.535 |
| R-HSA-373760 | L1CAM interactions | 0.291443 | 0.535 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.293439 | 0.532 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.293439 | 0.532 |
| R-HSA-169911 | Regulation of Apoptosis | 0.293439 | 0.532 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.293439 | 0.532 |
| R-HSA-162582 | Signal Transduction | 0.298210 | 0.525 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.299266 | 0.524 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.299266 | 0.524 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.299266 | 0.524 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.299266 | 0.524 |
| R-HSA-111933 | Calmodulin induced events | 0.299266 | 0.524 |
| R-HSA-111997 | CaM pathway | 0.299266 | 0.524 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.299266 | 0.524 |
| R-HSA-4641258 | Degradation of DVL | 0.305045 | 0.516 |
| R-HSA-4641257 | Degradation of AXIN | 0.305045 | 0.516 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.305045 | 0.516 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.305045 | 0.516 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.306638 | 0.513 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.316462 | 0.500 |
| R-HSA-71336 | Pentose phosphate pathway | 0.316462 | 0.500 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.316462 | 0.500 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.316462 | 0.500 |
| R-HSA-212436 | Generic Transcription Pathway | 0.318531 | 0.497 |
| R-HSA-8951664 | Neddylation | 0.320727 | 0.494 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.322100 | 0.492 |
| R-HSA-9646399 | Aggrephagy | 0.322100 | 0.492 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.322100 | 0.492 |
| R-HSA-202433 | Generation of second messenger molecules | 0.322100 | 0.492 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.327693 | 0.485 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.327693 | 0.485 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.327693 | 0.485 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.327693 | 0.485 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.327693 | 0.485 |
| R-HSA-9694548 | Maturation of spike protein | 0.327693 | 0.485 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.333239 | 0.477 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.333239 | 0.477 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.333239 | 0.477 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.333239 | 0.477 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.333239 | 0.477 |
| R-HSA-111996 | Ca-dependent events | 0.338741 | 0.470 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.338741 | 0.470 |
| R-HSA-1474165 | Reproduction | 0.339828 | 0.469 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.344197 | 0.463 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.344197 | 0.463 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.344197 | 0.463 |
| R-HSA-72312 | rRNA processing | 0.345500 | 0.462 |
| R-HSA-9907900 | Proteasome assembly | 0.349608 | 0.456 |
| R-HSA-190828 | Gap junction trafficking | 0.349608 | 0.456 |
| R-HSA-5683826 | Surfactant metabolism | 0.349608 | 0.456 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.349608 | 0.456 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.349608 | 0.456 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.349608 | 0.456 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.354975 | 0.450 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.354975 | 0.450 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.354975 | 0.450 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.354975 | 0.450 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.354975 | 0.450 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.354975 | 0.450 |
| R-HSA-9824272 | Somitogenesis | 0.354975 | 0.450 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.354975 | 0.450 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.359823 | 0.444 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.360298 | 0.443 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.360298 | 0.443 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.360704 | 0.443 |
| R-HSA-437239 | Recycling pathway of L1 | 0.365578 | 0.437 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.365578 | 0.437 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.365578 | 0.437 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.369579 | 0.432 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.370814 | 0.431 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.376008 | 0.425 |
| R-HSA-912446 | Meiotic recombination | 0.386267 | 0.413 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.386267 | 0.413 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.386267 | 0.413 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.386267 | 0.413 |
| R-HSA-72187 | mRNA 3'-end processing | 0.391334 | 0.407 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.391334 | 0.407 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.391334 | 0.407 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.391334 | 0.407 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.391334 | 0.407 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.396359 | 0.402 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.396359 | 0.402 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.396359 | 0.402 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.396359 | 0.402 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.396359 | 0.402 |
| R-HSA-5688426 | Deubiquitination | 0.396959 | 0.401 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.401343 | 0.396 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.404571 | 0.393 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.406286 | 0.391 |
| R-HSA-418597 | G alpha (z) signalling events | 0.406286 | 0.391 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.406286 | 0.391 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.410316 | 0.387 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.411189 | 0.386 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.411189 | 0.386 |
| R-HSA-5578775 | Ion homeostasis | 0.411189 | 0.386 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.411189 | 0.386 |
| R-HSA-69306 | DNA Replication | 0.413178 | 0.384 |
| R-HSA-9609507 | Protein localization | 0.413178 | 0.384 |
| R-HSA-73887 | Death Receptor Signaling | 0.416034 | 0.381 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.425658 | 0.371 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.425658 | 0.371 |
| R-HSA-180786 | Extension of Telomeres | 0.425658 | 0.371 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.425658 | 0.371 |
| R-HSA-9711097 | Cellular response to starvation | 0.427387 | 0.369 |
| R-HSA-913531 | Interferon Signaling | 0.428707 | 0.368 |
| R-HSA-351202 | Metabolism of polyamines | 0.430402 | 0.366 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.430402 | 0.366 |
| R-HSA-379724 | tRNA Aminoacylation | 0.430402 | 0.366 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.430402 | 0.366 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.433614 | 0.363 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.435107 | 0.361 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.435107 | 0.361 |
| R-HSA-112043 | PLC beta mediated events | 0.435107 | 0.361 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.435107 | 0.361 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.439773 | 0.357 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.439773 | 0.357 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.439773 | 0.357 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.439773 | 0.357 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.439773 | 0.357 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.444401 | 0.352 |
| R-HSA-8848021 | Signaling by PTK6 | 0.444401 | 0.352 |
| R-HSA-392499 | Metabolism of proteins | 0.447475 | 0.349 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.448992 | 0.348 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.453544 | 0.343 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.455929 | 0.341 |
| R-HSA-112040 | G-protein mediated events | 0.462538 | 0.335 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.462538 | 0.335 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.466979 | 0.331 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.470845 | 0.327 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.471608 | 0.326 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.475753 | 0.323 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.475753 | 0.323 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.475753 | 0.323 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.476993 | 0.321 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.480087 | 0.319 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.480087 | 0.319 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.480087 | 0.319 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.480087 | 0.319 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.484384 | 0.315 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.485579 | 0.314 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.488646 | 0.311 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.488646 | 0.311 |
| R-HSA-195721 | Signaling by WNT | 0.489753 | 0.310 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.492874 | 0.307 |
| R-HSA-1643685 | Disease | 0.496725 | 0.304 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.497066 | 0.304 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.497066 | 0.304 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.498200 | 0.303 |
| R-HSA-5689603 | UCH proteinases | 0.501225 | 0.300 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.505349 | 0.296 |
| R-HSA-69275 | G2/M Transition | 0.506011 | 0.296 |
| R-HSA-5619084 | ABC transporter disorders | 0.509439 | 0.293 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.511175 | 0.291 |
| R-HSA-72766 | Translation | 0.511441 | 0.291 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.517519 | 0.286 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.517519 | 0.286 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.518856 | 0.285 |
| R-HSA-1280218 | Adaptive Immune System | 0.523178 | 0.281 |
| R-HSA-68877 | Mitotic Prometaphase | 0.523932 | 0.281 |
| R-HSA-597592 | Post-translational protein modification | 0.527507 | 0.278 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.529392 | 0.276 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.533285 | 0.273 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.537146 | 0.270 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.540482 | 0.267 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.540976 | 0.267 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.540976 | 0.267 |
| R-HSA-168256 | Immune System | 0.541943 | 0.266 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.544773 | 0.264 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.548540 | 0.261 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.548773 | 0.261 |
| R-HSA-9663891 | Selective autophagy | 0.552276 | 0.258 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.555981 | 0.255 |
| R-HSA-202424 | Downstream TCR signaling | 0.559655 | 0.252 |
| R-HSA-168249 | Innate Immune System | 0.563870 | 0.249 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.570499 | 0.244 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.570499 | 0.244 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.572702 | 0.242 |
| R-HSA-397014 | Muscle contraction | 0.572702 | 0.242 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.575189 | 0.240 |
| R-HSA-1474290 | Collagen formation | 0.577580 | 0.238 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.584546 | 0.233 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.587986 | 0.231 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.587986 | 0.231 |
| R-HSA-157579 | Telomere Maintenance | 0.591397 | 0.228 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.594781 | 0.226 |
| R-HSA-190236 | Signaling by FGFR | 0.594781 | 0.226 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.601465 | 0.221 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.601465 | 0.221 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.604113 | 0.219 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.604766 | 0.218 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.608040 | 0.216 |
| R-HSA-73894 | DNA Repair | 0.610027 | 0.215 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.613440 | 0.212 |
| R-HSA-111885 | Opioid Signalling | 0.614506 | 0.211 |
| R-HSA-15869 | Metabolism of nucleotides | 0.626350 | 0.203 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.630214 | 0.201 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.651143 | 0.186 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.651266 | 0.186 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.654035 | 0.184 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.656904 | 0.182 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.662570 | 0.179 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.665368 | 0.177 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.668143 | 0.175 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.673625 | 0.172 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.689604 | 0.161 |
| R-HSA-114608 | Platelet degranulation | 0.692114 | 0.160 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.694669 | 0.158 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.700473 | 0.155 |
| R-HSA-5576891 | Cardiac conduction | 0.704680 | 0.152 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.707132 | 0.150 |
| R-HSA-9909396 | Circadian clock | 0.707132 | 0.150 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.709563 | 0.149 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.711529 | 0.148 |
| R-HSA-163685 | Integration of energy metabolism | 0.719090 | 0.143 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.723736 | 0.140 |
| R-HSA-1632852 | Macroautophagy | 0.730562 | 0.136 |
| R-HSA-1483257 | Phospholipid metabolism | 0.735988 | 0.133 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.739405 | 0.131 |
| R-HSA-166520 | Signaling by NTRKs | 0.747959 | 0.126 |
| R-HSA-9758941 | Gastrulation | 0.750054 | 0.125 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.756235 | 0.121 |
| R-HSA-9612973 | Autophagy | 0.764241 | 0.117 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.768145 | 0.115 |
| R-HSA-877300 | Interferon gamma signaling | 0.770073 | 0.113 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.771986 | 0.112 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.777753 | 0.109 |
| R-HSA-449147 | Signaling by Interleukins | 0.784768 | 0.105 |
| R-HSA-1474244 | Extracellular matrix organization | 0.788584 | 0.103 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.798845 | 0.098 |
| R-HSA-109582 | Hemostasis | 0.799623 | 0.097 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.800520 | 0.097 |
| R-HSA-983712 | Ion channel transport | 0.822562 | 0.085 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.827420 | 0.082 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.828524 | 0.082 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.829833 | 0.081 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.838170 | 0.077 |
| R-HSA-428157 | Sphingolipid metabolism | 0.839519 | 0.076 |
| R-HSA-382551 | Transport of small molecules | 0.841335 | 0.075 |
| R-HSA-72172 | mRNA Splicing | 0.844806 | 0.073 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.870940 | 0.060 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.882318 | 0.054 |
| R-HSA-157118 | Signaling by NOTCH | 0.885244 | 0.053 |
| R-HSA-388396 | GPCR downstream signalling | 0.898525 | 0.046 |
| R-HSA-416476 | G alpha (q) signalling events | 0.906199 | 0.043 |
| R-HSA-112316 | Neuronal System | 0.914517 | 0.039 |
| R-HSA-372790 | Signaling by GPCR | 0.935687 | 0.029 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.967892 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.969742 | 0.013 |
| R-HSA-418594 | G alpha (i) signalling events | 0.972203 | 0.012 |
| R-HSA-5668914 | Diseases of metabolism | 0.976544 | 0.010 |
| R-HSA-1430728 | Metabolism | 0.978693 | 0.009 |
| R-HSA-9709957 | Sensory Perception | 0.999754 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999775 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.843 | 0.130 | 2 | 0.841 |
CAMK2G |
0.832 | 0.123 | 2 | 0.828 |
CDC7 |
0.829 | -0.002 | 1 | 0.774 |
IKKB |
0.828 | 0.003 | -2 | 0.720 |
GRK1 |
0.827 | 0.148 | -2 | 0.727 |
GCN2 |
0.826 | -0.096 | 2 | 0.777 |
PRPK |
0.826 | -0.064 | -1 | 0.848 |
PIM3 |
0.825 | 0.073 | -3 | 0.739 |
DSTYK |
0.825 | 0.006 | 2 | 0.842 |
MOS |
0.825 | 0.034 | 1 | 0.805 |
NDR2 |
0.824 | 0.042 | -3 | 0.740 |
CAMK1B |
0.822 | -0.014 | -3 | 0.784 |
PDHK4 |
0.822 | -0.152 | 1 | 0.796 |
GRK6 |
0.822 | 0.093 | 1 | 0.790 |
PRKD1 |
0.822 | 0.050 | -3 | 0.754 |
TBK1 |
0.821 | -0.081 | 1 | 0.706 |
ATR |
0.820 | 0.018 | 1 | 0.811 |
RAF1 |
0.820 | -0.103 | 1 | 0.796 |
RIPK3 |
0.819 | -0.016 | 3 | 0.729 |
IKKE |
0.819 | -0.083 | 1 | 0.696 |
BMPR2 |
0.818 | -0.104 | -2 | 0.832 |
RSK2 |
0.818 | 0.019 | -3 | 0.671 |
MTOR |
0.818 | -0.120 | 1 | 0.728 |
WNK1 |
0.817 | -0.010 | -2 | 0.810 |
NEK7 |
0.817 | -0.073 | -3 | 0.813 |
ULK2 |
0.817 | -0.137 | 2 | 0.751 |
GRK5 |
0.817 | -0.041 | -3 | 0.832 |
IKKA |
0.817 | 0.035 | -2 | 0.712 |
PIM1 |
0.817 | 0.096 | -3 | 0.682 |
PDHK1 |
0.817 | -0.135 | 1 | 0.795 |
NEK6 |
0.817 | -0.028 | -2 | 0.826 |
CAMK2D |
0.817 | 0.032 | -3 | 0.772 |
CAMK2B |
0.817 | 0.108 | 2 | 0.802 |
PRKD2 |
0.816 | 0.027 | -3 | 0.669 |
CLK3 |
0.815 | 0.035 | 1 | 0.743 |
NLK |
0.815 | -0.054 | 1 | 0.745 |
FAM20C |
0.814 | 0.064 | 2 | 0.570 |
MLK1 |
0.814 | -0.051 | 2 | 0.777 |
MST4 |
0.814 | 0.004 | 2 | 0.842 |
LATS2 |
0.813 | 0.017 | -5 | 0.712 |
NDR1 |
0.813 | -0.029 | -3 | 0.734 |
HUNK |
0.813 | -0.081 | 2 | 0.774 |
SKMLCK |
0.813 | 0.001 | -2 | 0.790 |
ERK5 |
0.812 | -0.016 | 1 | 0.709 |
GRK4 |
0.812 | -0.021 | -2 | 0.764 |
ATM |
0.812 | 0.045 | 1 | 0.765 |
PKN3 |
0.811 | -0.058 | -3 | 0.733 |
CDKL1 |
0.811 | -0.047 | -3 | 0.724 |
NUAK2 |
0.811 | -0.039 | -3 | 0.738 |
CAMLCK |
0.810 | -0.035 | -2 | 0.793 |
BCKDK |
0.810 | -0.099 | -1 | 0.796 |
P90RSK |
0.810 | -0.028 | -3 | 0.677 |
NIK |
0.810 | -0.107 | -3 | 0.808 |
CHAK2 |
0.809 | -0.065 | -1 | 0.833 |
ULK1 |
0.809 | -0.146 | -3 | 0.795 |
WNK3 |
0.809 | -0.154 | 1 | 0.794 |
NEK9 |
0.809 | -0.078 | 2 | 0.806 |
PKACG |
0.809 | -0.008 | -2 | 0.721 |
TGFBR2 |
0.808 | -0.092 | -2 | 0.743 |
TGFBR1 |
0.808 | 0.058 | -2 | 0.743 |
KIS |
0.808 | -0.014 | 1 | 0.596 |
CAMK2A |
0.808 | 0.062 | 2 | 0.822 |
MAPKAPK2 |
0.808 | 0.002 | -3 | 0.630 |
MASTL |
0.807 | -0.135 | -2 | 0.779 |
PKN2 |
0.807 | -0.070 | -3 | 0.756 |
MARK4 |
0.807 | -0.066 | 4 | 0.782 |
AMPKA1 |
0.807 | -0.048 | -3 | 0.758 |
DNAPK |
0.807 | 0.102 | 1 | 0.696 |
RSK3 |
0.807 | -0.044 | -3 | 0.666 |
RIPK1 |
0.806 | -0.106 | 1 | 0.796 |
TSSK2 |
0.806 | -0.021 | -5 | 0.795 |
MAPKAPK3 |
0.806 | -0.058 | -3 | 0.685 |
P70S6KB |
0.806 | -0.036 | -3 | 0.697 |
PLK1 |
0.806 | -0.002 | -2 | 0.795 |
BMPR1B |
0.805 | 0.066 | 1 | 0.734 |
DAPK2 |
0.805 | -0.088 | -3 | 0.792 |
TSSK1 |
0.805 | -0.010 | -3 | 0.771 |
PKR |
0.805 | 0.047 | 1 | 0.816 |
DLK |
0.805 | -0.093 | 1 | 0.794 |
ANKRD3 |
0.804 | -0.094 | 1 | 0.831 |
CDKL5 |
0.804 | -0.044 | -3 | 0.715 |
NIM1 |
0.804 | -0.066 | 3 | 0.727 |
PKCD |
0.803 | -0.041 | 2 | 0.768 |
AURC |
0.802 | 0.017 | -2 | 0.624 |
MSK2 |
0.802 | -0.042 | -3 | 0.669 |
ALK4 |
0.802 | -0.013 | -2 | 0.766 |
SRPK1 |
0.802 | -0.034 | -3 | 0.670 |
TTBK2 |
0.801 | -0.155 | 2 | 0.682 |
ALK2 |
0.801 | 0.055 | -2 | 0.757 |
IRE1 |
0.801 | -0.094 | 1 | 0.784 |
ICK |
0.801 | -0.054 | -3 | 0.765 |
MSK1 |
0.801 | 0.006 | -3 | 0.662 |
CAMK4 |
0.800 | -0.101 | -3 | 0.729 |
SMG1 |
0.800 | 0.006 | 1 | 0.779 |
PLK3 |
0.800 | -0.020 | 2 | 0.753 |
MLK2 |
0.800 | -0.122 | 2 | 0.772 |
HIPK4 |
0.799 | -0.078 | 1 | 0.710 |
CDK8 |
0.798 | -0.059 | 1 | 0.590 |
LATS1 |
0.798 | -0.002 | -3 | 0.747 |
AMPKA2 |
0.798 | -0.068 | -3 | 0.716 |
ACVR2B |
0.798 | 0.007 | -2 | 0.741 |
PAK1 |
0.797 | -0.043 | -2 | 0.706 |
MEK1 |
0.797 | -0.108 | 2 | 0.809 |
NUAK1 |
0.797 | -0.053 | -3 | 0.679 |
VRK2 |
0.797 | -0.091 | 1 | 0.836 |
ACVR2A |
0.797 | -0.009 | -2 | 0.727 |
RSK4 |
0.796 | -0.006 | -3 | 0.625 |
PRKD3 |
0.796 | -0.046 | -3 | 0.659 |
GRK7 |
0.796 | 0.010 | 1 | 0.721 |
CK1E |
0.796 | 0.070 | -3 | 0.622 |
GSK3B |
0.796 | 0.094 | 4 | 0.528 |
TLK2 |
0.796 | -0.048 | 1 | 0.780 |
PKACB |
0.795 | 0.015 | -2 | 0.647 |
MLK3 |
0.795 | -0.086 | 2 | 0.714 |
YSK4 |
0.795 | -0.110 | 1 | 0.739 |
MYLK4 |
0.795 | -0.042 | -2 | 0.709 |
AURB |
0.794 | -0.009 | -2 | 0.625 |
GAK |
0.794 | 0.307 | 1 | 0.895 |
MNK2 |
0.794 | -0.064 | -2 | 0.752 |
PRKX |
0.794 | 0.050 | -3 | 0.547 |
MELK |
0.793 | -0.093 | -3 | 0.705 |
NEK2 |
0.793 | -0.119 | 2 | 0.766 |
PAK3 |
0.792 | -0.102 | -2 | 0.708 |
PKCA |
0.792 | -0.054 | 2 | 0.703 |
CDK19 |
0.792 | -0.059 | 1 | 0.553 |
BMPR1A |
0.792 | 0.052 | 1 | 0.723 |
AURA |
0.792 | -0.013 | -2 | 0.596 |
QIK |
0.792 | -0.143 | -3 | 0.759 |
PKCB |
0.792 | -0.055 | 2 | 0.711 |
QSK |
0.792 | -0.070 | 4 | 0.746 |
IRE2 |
0.791 | -0.101 | 2 | 0.711 |
GRK2 |
0.791 | -0.042 | -2 | 0.669 |
CAMK1G |
0.791 | -0.060 | -3 | 0.671 |
SRPK2 |
0.791 | -0.055 | -3 | 0.585 |
PIM2 |
0.791 | 0.014 | -3 | 0.645 |
MLK4 |
0.791 | -0.095 | 2 | 0.684 |
PKG2 |
0.791 | -0.023 | -2 | 0.655 |
SRPK3 |
0.791 | -0.065 | -3 | 0.647 |
GSK3A |
0.790 | 0.090 | 4 | 0.543 |
MNK1 |
0.790 | -0.059 | -2 | 0.761 |
MAPKAPK5 |
0.789 | -0.116 | -3 | 0.643 |
MARK2 |
0.789 | -0.062 | 4 | 0.706 |
MEKK1 |
0.789 | -0.073 | 1 | 0.801 |
DYRK2 |
0.789 | -0.067 | 1 | 0.612 |
CLK4 |
0.789 | -0.037 | -3 | 0.665 |
PAK2 |
0.789 | -0.088 | -2 | 0.694 |
CK1D |
0.789 | 0.077 | -3 | 0.590 |
CK1A2 |
0.788 | 0.083 | -3 | 0.581 |
JNK3 |
0.788 | -0.033 | 1 | 0.549 |
SIK |
0.788 | -0.089 | -3 | 0.666 |
SGK3 |
0.788 | -0.041 | -3 | 0.660 |
MEKK3 |
0.788 | -0.098 | 1 | 0.764 |
WNK4 |
0.788 | -0.076 | -2 | 0.803 |
PKCG |
0.788 | -0.099 | 2 | 0.707 |
PKCZ |
0.787 | -0.090 | 2 | 0.735 |
CHK1 |
0.787 | -0.076 | -3 | 0.706 |
JNK2 |
0.787 | -0.021 | 1 | 0.512 |
PASK |
0.787 | 0.017 | -3 | 0.771 |
PKCH |
0.787 | -0.100 | 2 | 0.692 |
PERK |
0.787 | -0.131 | -2 | 0.784 |
CK1G1 |
0.787 | 0.036 | -3 | 0.612 |
HRI |
0.787 | -0.151 | -2 | 0.781 |
CDK1 |
0.787 | -0.045 | 1 | 0.528 |
PAK6 |
0.786 | -0.051 | -2 | 0.641 |
MARK3 |
0.786 | -0.074 | 4 | 0.730 |
CHAK1 |
0.786 | -0.179 | 2 | 0.687 |
CDK7 |
0.786 | -0.088 | 1 | 0.584 |
BRAF |
0.786 | -0.077 | -4 | 0.739 |
CLK2 |
0.786 | 0.021 | -3 | 0.638 |
CLK1 |
0.785 | -0.043 | -3 | 0.645 |
P38A |
0.785 | -0.044 | 1 | 0.606 |
CK2A2 |
0.785 | 0.058 | 1 | 0.623 |
TLK1 |
0.785 | -0.104 | -2 | 0.767 |
NEK5 |
0.785 | -0.058 | 1 | 0.824 |
CDK2 |
0.785 | -0.059 | 1 | 0.622 |
AKT2 |
0.785 | -0.041 | -3 | 0.585 |
PLK4 |
0.784 | -0.121 | 2 | 0.598 |
CDK18 |
0.784 | -0.049 | 1 | 0.521 |
CDK5 |
0.784 | -0.055 | 1 | 0.611 |
CAMKK1 |
0.784 | -0.035 | -2 | 0.765 |
DRAK1 |
0.784 | -0.128 | 1 | 0.709 |
ZAK |
0.784 | -0.121 | 1 | 0.770 |
PHKG1 |
0.783 | -0.157 | -3 | 0.736 |
BRSK1 |
0.783 | -0.124 | -3 | 0.693 |
MPSK1 |
0.783 | 0.100 | 1 | 0.834 |
BRSK2 |
0.783 | -0.146 | -3 | 0.727 |
SSTK |
0.783 | -0.038 | 4 | 0.728 |
MST3 |
0.783 | -0.047 | 2 | 0.795 |
P38B |
0.782 | -0.036 | 1 | 0.520 |
SNRK |
0.782 | -0.208 | 2 | 0.630 |
IRAK4 |
0.782 | -0.099 | 1 | 0.800 |
MEK5 |
0.782 | -0.233 | 2 | 0.784 |
GRK3 |
0.782 | -0.023 | -2 | 0.624 |
IRAK1 |
0.781 | -0.122 | -1 | 0.753 |
PKACA |
0.781 | -0.007 | -2 | 0.602 |
TTBK1 |
0.781 | -0.136 | 2 | 0.604 |
SMMLCK |
0.781 | -0.071 | -3 | 0.740 |
CDK13 |
0.781 | -0.093 | 1 | 0.554 |
MARK1 |
0.781 | -0.113 | 4 | 0.742 |
PRP4 |
0.781 | -0.057 | -3 | 0.726 |
DCAMKL1 |
0.780 | -0.095 | -3 | 0.673 |
ERK1 |
0.780 | -0.058 | 1 | 0.518 |
MEKK2 |
0.780 | -0.125 | 2 | 0.769 |
P70S6K |
0.779 | -0.066 | -3 | 0.613 |
ERK2 |
0.779 | -0.082 | 1 | 0.559 |
CAMKK2 |
0.779 | -0.045 | -2 | 0.765 |
PLK2 |
0.779 | -0.000 | -3 | 0.728 |
CAMK1D |
0.778 | -0.048 | -3 | 0.577 |
PINK1 |
0.778 | -0.170 | 1 | 0.794 |
CDK14 |
0.778 | -0.048 | 1 | 0.571 |
P38G |
0.777 | -0.056 | 1 | 0.445 |
CDK17 |
0.777 | -0.070 | 1 | 0.458 |
HIPK1 |
0.777 | -0.057 | 1 | 0.639 |
DYRK4 |
0.776 | -0.045 | 1 | 0.531 |
DCAMKL2 |
0.776 | -0.106 | -3 | 0.703 |
TAO3 |
0.776 | -0.105 | 1 | 0.749 |
NEK11 |
0.775 | -0.152 | 1 | 0.745 |
CK2A1 |
0.775 | 0.041 | 1 | 0.596 |
PHKG2 |
0.775 | -0.131 | -3 | 0.702 |
TAK1 |
0.774 | -0.025 | 1 | 0.791 |
AKT1 |
0.774 | -0.045 | -3 | 0.599 |
CDK16 |
0.774 | -0.032 | 1 | 0.482 |
HIPK2 |
0.773 | -0.058 | 1 | 0.522 |
DYRK1A |
0.773 | -0.089 | 1 | 0.638 |
P38D |
0.773 | -0.025 | 1 | 0.488 |
CDK9 |
0.773 | -0.109 | 1 | 0.564 |
PKCT |
0.773 | -0.112 | 2 | 0.703 |
NEK4 |
0.772 | -0.096 | 1 | 0.771 |
CDK3 |
0.772 | -0.030 | 1 | 0.478 |
CDK12 |
0.771 | -0.102 | 1 | 0.521 |
MST2 |
0.771 | -0.089 | 1 | 0.766 |
DAPK3 |
0.771 | -0.046 | -3 | 0.702 |
NEK8 |
0.771 | -0.188 | 2 | 0.770 |
VRK1 |
0.770 | -0.069 | 2 | 0.798 |
TAO2 |
0.770 | -0.138 | 2 | 0.816 |
PKCI |
0.770 | -0.106 | 2 | 0.709 |
HIPK3 |
0.770 | -0.096 | 1 | 0.622 |
BIKE |
0.770 | 0.289 | 1 | 0.856 |
LKB1 |
0.770 | -0.088 | -3 | 0.795 |
EEF2K |
0.769 | -0.084 | 3 | 0.751 |
PBK |
0.769 | 0.192 | 1 | 0.858 |
PDK1 |
0.768 | -0.136 | 1 | 0.749 |
CDK10 |
0.768 | -0.053 | 1 | 0.555 |
DYRK3 |
0.767 | -0.073 | 1 | 0.645 |
GCK |
0.767 | -0.092 | 1 | 0.745 |
NEK1 |
0.767 | -0.083 | 1 | 0.792 |
MINK |
0.767 | -0.090 | 1 | 0.756 |
DYRK1B |
0.767 | -0.083 | 1 | 0.565 |
DAPK1 |
0.766 | -0.055 | -3 | 0.692 |
JNK1 |
0.766 | -0.053 | 1 | 0.502 |
CAMK1A |
0.766 | -0.051 | -3 | 0.558 |
MEKK6 |
0.766 | -0.130 | 1 | 0.771 |
PAK5 |
0.766 | -0.093 | -2 | 0.581 |
PKCE |
0.766 | -0.072 | 2 | 0.689 |
STK33 |
0.766 | -0.122 | 2 | 0.589 |
MRCKA |
0.765 | -0.040 | -3 | 0.649 |
PAK4 |
0.765 | -0.076 | -2 | 0.592 |
MAP3K15 |
0.764 | -0.138 | 1 | 0.746 |
TNIK |
0.764 | -0.082 | 3 | 0.768 |
SGK1 |
0.764 | -0.031 | -3 | 0.504 |
MRCKB |
0.763 | -0.039 | -3 | 0.637 |
MST1 |
0.763 | -0.106 | 1 | 0.750 |
HGK |
0.763 | -0.123 | 3 | 0.778 |
ERK7 |
0.762 | -0.059 | 2 | 0.486 |
LRRK2 |
0.762 | -0.191 | 2 | 0.802 |
RIPK2 |
0.762 | -0.198 | 1 | 0.715 |
CHK2 |
0.762 | -0.084 | -3 | 0.534 |
ROCK2 |
0.761 | -0.029 | -3 | 0.682 |
LOK |
0.761 | -0.119 | -2 | 0.754 |
HPK1 |
0.761 | -0.112 | 1 | 0.718 |
BUB1 |
0.761 | 0.016 | -5 | 0.754 |
AKT3 |
0.760 | -0.044 | -3 | 0.526 |
PDHK3_TYR |
0.760 | 0.181 | 4 | 0.844 |
DMPK1 |
0.760 | 0.014 | -3 | 0.653 |
PKN1 |
0.759 | -0.118 | -3 | 0.632 |
CDK6 |
0.757 | -0.075 | 1 | 0.555 |
MAK |
0.756 | -0.013 | -2 | 0.663 |
YSK1 |
0.756 | -0.126 | 2 | 0.777 |
YANK3 |
0.756 | -0.018 | 2 | 0.396 |
MEK2 |
0.756 | -0.238 | 2 | 0.778 |
AAK1 |
0.755 | 0.312 | 1 | 0.778 |
KHS1 |
0.755 | -0.102 | 1 | 0.729 |
SLK |
0.754 | -0.143 | -2 | 0.696 |
CK1A |
0.754 | 0.042 | -3 | 0.506 |
SBK |
0.754 | -0.049 | -3 | 0.465 |
TTK |
0.753 | -0.041 | -2 | 0.780 |
NEK3 |
0.753 | -0.147 | 1 | 0.745 |
CDK4 |
0.753 | -0.091 | 1 | 0.514 |
PKG1 |
0.753 | -0.062 | -2 | 0.584 |
KHS2 |
0.752 | -0.087 | 1 | 0.734 |
MAP2K6_TYR |
0.752 | 0.090 | -1 | 0.870 |
CRIK |
0.751 | -0.019 | -3 | 0.600 |
PDHK4_TYR |
0.751 | 0.071 | 2 | 0.835 |
BMPR2_TYR |
0.751 | 0.061 | -1 | 0.881 |
MOK |
0.750 | -0.053 | 1 | 0.654 |
ALPHAK3 |
0.750 | -0.038 | -1 | 0.771 |
ROCK1 |
0.749 | -0.049 | -3 | 0.648 |
MAP2K4_TYR |
0.748 | -0.025 | -1 | 0.861 |
OSR1 |
0.748 | -0.104 | 2 | 0.769 |
PKMYT1_TYR |
0.748 | -0.002 | 3 | 0.800 |
PDHK1_TYR |
0.746 | -0.007 | -1 | 0.886 |
TESK1_TYR |
0.746 | -0.127 | 3 | 0.814 |
MAP2K7_TYR |
0.746 | -0.174 | 2 | 0.817 |
HASPIN |
0.744 | -0.071 | -1 | 0.673 |
ASK1 |
0.744 | -0.139 | 1 | 0.735 |
MYO3B |
0.743 | -0.104 | 2 | 0.776 |
EPHA6 |
0.742 | 0.011 | -1 | 0.884 |
PINK1_TYR |
0.742 | -0.170 | 1 | 0.789 |
EPHB4 |
0.741 | -0.002 | -1 | 0.859 |
MYO3A |
0.740 | -0.129 | 1 | 0.747 |
YES1 |
0.739 | 0.054 | -1 | 0.844 |
DDR1 |
0.739 | -0.086 | 4 | 0.783 |
LIMK2_TYR |
0.738 | -0.112 | -3 | 0.829 |
FGR |
0.737 | 0.021 | 1 | 0.844 |
EPHA4 |
0.737 | 0.009 | 2 | 0.747 |
RET |
0.736 | -0.152 | 1 | 0.773 |
TAO1 |
0.736 | -0.166 | 1 | 0.691 |
TYK2 |
0.736 | -0.147 | 1 | 0.778 |
TXK |
0.736 | 0.036 | 1 | 0.781 |
CK1G3 |
0.734 | 0.034 | -3 | 0.460 |
MST1R |
0.734 | -0.167 | 3 | 0.736 |
HCK |
0.734 | 0.022 | -1 | 0.847 |
FER |
0.733 | -0.060 | 1 | 0.827 |
LIMK1_TYR |
0.733 | -0.213 | 2 | 0.808 |
JAK2 |
0.733 | -0.140 | 1 | 0.768 |
INSRR |
0.732 | -0.049 | 3 | 0.698 |
EPHB2 |
0.732 | 0.004 | -1 | 0.846 |
SRMS |
0.732 | -0.035 | 1 | 0.801 |
ITK |
0.732 | -0.015 | -1 | 0.819 |
TYRO3 |
0.732 | -0.148 | 3 | 0.728 |
STLK3 |
0.732 | -0.182 | 1 | 0.725 |
CSF1R |
0.731 | -0.122 | 3 | 0.738 |
EPHB3 |
0.731 | -0.017 | -1 | 0.850 |
EPHB1 |
0.731 | -0.046 | 1 | 0.794 |
ROS1 |
0.731 | -0.158 | 3 | 0.705 |
ABL2 |
0.731 | -0.061 | -1 | 0.806 |
LCK |
0.730 | 0.059 | -1 | 0.857 |
FYN |
0.730 | 0.106 | -1 | 0.838 |
BLK |
0.730 | 0.075 | -1 | 0.858 |
JAK3 |
0.729 | -0.111 | 1 | 0.755 |
KIT |
0.727 | -0.108 | 3 | 0.744 |
ABL1 |
0.727 | -0.076 | -1 | 0.798 |
PDGFRB |
0.727 | -0.134 | 3 | 0.742 |
KDR |
0.727 | -0.091 | 3 | 0.720 |
FGFR2 |
0.726 | -0.131 | 3 | 0.745 |
TNK2 |
0.726 | -0.095 | 3 | 0.678 |
FLT1 |
0.725 | -0.044 | -1 | 0.849 |
MERTK |
0.725 | -0.065 | 3 | 0.717 |
FLT3 |
0.725 | -0.138 | 3 | 0.727 |
YANK2 |
0.724 | -0.039 | 2 | 0.413 |
EPHA7 |
0.723 | -0.046 | 2 | 0.745 |
EPHA3 |
0.723 | -0.066 | 2 | 0.721 |
BMX |
0.722 | -0.047 | -1 | 0.738 |
DDR2 |
0.722 | -0.012 | 3 | 0.680 |
CK1G2 |
0.721 | 0.027 | -3 | 0.542 |
NTRK1 |
0.721 | -0.120 | -1 | 0.811 |
NEK10_TYR |
0.721 | -0.146 | 1 | 0.633 |
AXL |
0.721 | -0.138 | 3 | 0.709 |
BTK |
0.720 | -0.146 | -1 | 0.773 |
ERBB2 |
0.720 | -0.115 | 1 | 0.743 |
TNK1 |
0.720 | -0.140 | 3 | 0.724 |
TEC |
0.719 | -0.093 | -1 | 0.747 |
LYN |
0.719 | -0.014 | 3 | 0.673 |
TEK |
0.719 | -0.164 | 3 | 0.677 |
EPHA5 |
0.719 | -0.024 | 2 | 0.729 |
JAK1 |
0.719 | -0.129 | 1 | 0.722 |
SRC |
0.719 | 0.032 | -1 | 0.824 |
PTK6 |
0.719 | -0.148 | -1 | 0.740 |
FGFR1 |
0.718 | -0.175 | 3 | 0.703 |
FLT4 |
0.718 | -0.117 | 3 | 0.734 |
TNNI3K_TYR |
0.718 | -0.102 | 1 | 0.797 |
MET |
0.718 | -0.128 | 3 | 0.711 |
WEE1_TYR |
0.718 | -0.119 | -1 | 0.746 |
PDGFRA |
0.717 | -0.228 | 3 | 0.735 |
LTK |
0.717 | -0.133 | 3 | 0.699 |
FGFR3 |
0.717 | -0.122 | 3 | 0.724 |
PTK2 |
0.714 | 0.031 | -1 | 0.829 |
EPHA1 |
0.714 | -0.127 | 3 | 0.686 |
EPHA8 |
0.714 | -0.056 | -1 | 0.844 |
NTRK2 |
0.714 | -0.166 | 3 | 0.697 |
ALK |
0.713 | -0.180 | 3 | 0.660 |
INSR |
0.713 | -0.138 | 3 | 0.667 |
PTK2B |
0.713 | -0.074 | -1 | 0.784 |
SYK |
0.712 | 0.022 | -1 | 0.808 |
EGFR |
0.712 | -0.062 | 1 | 0.664 |
FRK |
0.712 | -0.132 | -1 | 0.856 |
NTRK3 |
0.711 | -0.127 | -1 | 0.767 |
FGFR4 |
0.707 | -0.094 | -1 | 0.776 |
EPHA2 |
0.706 | -0.049 | -1 | 0.806 |
CSK |
0.706 | -0.139 | 2 | 0.748 |
MATK |
0.704 | -0.143 | -1 | 0.731 |
ERBB4 |
0.703 | -0.032 | 1 | 0.671 |
IGF1R |
0.702 | -0.109 | 3 | 0.616 |
MUSK |
0.697 | -0.153 | 1 | 0.655 |
FES |
0.690 | -0.121 | -1 | 0.714 |
ZAP70 |
0.685 | -0.042 | -1 | 0.722 |