Motif 965 (n=159)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JPF8 | HNRNPCL4 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| A0A0U1RQJ8 | ATRIP | S325 | ochoa | ATR interacting protein | None |
| A6NMY6 | ANXA2P2 | S117 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A6NNZ2 | TUBB8B | S278 | ochoa | Tubulin beta 8B | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| B2RXH8 | HNRNPCL2 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| O14561 | NDUFAB1 | S99 | ochoa | Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) | Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:P52505, ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:31664822}. |
| O14578 | CIT | S440 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14818 | PSMA7 | S201 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O43707 | ACTN4 | S423 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43707 | ACTN4 | S461 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60812 | HNRNPCL1 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O75116 | ROCK2 | S1121 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O75940 | SMNDC1 | S60 | ochoa | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
| O95168 | NDUFB4 | S26 | ochoa | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O95490 | ADGRL2 | S1350 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| O95671 | ASMTL | S223 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| O96018 | APBA3 | S46 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) | May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}. |
| P04233 | CD74 | S45 | psp | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}. |
| P04350 | TUBB4A | S278 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05814 | CSN2 | S21 | psp | Beta-casein | Important role in determination of the surface properties of the casein micelles. |
| P06744 | GPI | S532 | ochoa | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
| P07355 | ANXA2 | S117 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07437 | TUBB | S278 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07910 | HNRNPC | S38 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P0DMR1 | HNRNPCL4 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P10275 | AR | S647 | ochoa | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P11055 | MYH3 | S949 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12814 | ACTN1 | S404 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12814 | ACTN1 | S442 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12882 | MYH1 | S952 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S948 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S950 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S951 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14618 | PKM | S346 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P14921 | ETS1 | S26 | ochoa | Protein C-ets-1 (p54) | Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000303|PubMed:20378371}.; FUNCTION: [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A. {ECO:0000269|PubMed:19377509}. |
| P17028 | ZNF24 | S39 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17600 | SYN1 | S390 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18146 | EGR1 | S301 | psp | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) | Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
| P18206 | VCL | S120 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20700 | LMNB1 | S58 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P29401 | TKT | S190 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P30307 | CDC25C | S75 | psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P35609 | ACTN2 | S201 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35609 | ACTN2 | S411 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35609 | ACTN2 | S449 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35869 | AHR | S444 | psp | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P48681 | NES | S51 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49327 | FASN | S1129 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P51948 | MNAT1 | S190 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P52799 | EFNB2 | S284 | ochoa | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}. |
| P62136 | PPP1CA | S22 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P68363 | TUBA1B | S237 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S237 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68371 | TUBB4B | S278 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q00535 | CDK5 | S47 | psp | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q03114, ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}. |
| Q04206 | RELA | S131 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q05513 | PRKCZ | S190 | ochoa | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q08043 | ACTN3 | S418 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q08043 | ACTN3 | S456 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q12955 | ANK3 | S4298 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13033 | STRN3 | S323 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q13151 | HNRNPA0 | S21 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13158 | FADD | S41 | ochoa | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:23955153, PubMed:24025841, PubMed:7538907, PubMed:9184224). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:7538907, PubMed:9184224). Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225, PubMed:24204270). {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225, ECO:0000269|PubMed:23955153, ECO:0000269|PubMed:24025841, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:7538907, ECO:0000269|PubMed:9184224}. |
| Q13422 | IKZF1 | S389 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13459 | MYO9B | S1999 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13535 | ATR | Y310 | psp | Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}. |
| Q13535 | ATR | S1333 | psp | Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}. |
| Q13813 | SPTAN1 | S2138 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13885 | TUBB2A | S278 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14156 | EFR3A | S694 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14161 | GIT2 | S360 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14807 | KIF22 | S455 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q14997 | PSME4 | S1614 | ochoa | Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10) | Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}. |
| Q15334 | LLGL1 | S488 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q16881 | TXNRD1 | S160 | ochoa | Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) | Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). {ECO:0000269|PubMed:10849437, ECO:0000269|PubMed:8577704, ECO:0000305|PubMed:17512005}.; FUNCTION: [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. {ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8577704}.; FUNCTION: [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. {ECO:0000269|PubMed:15199063}.; FUNCTION: [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665). {ECO:0000269|PubMed:15199063, ECO:0000269|PubMed:9774665}. |
| Q3MJ13 | WDR72 | S970 | ochoa | WD repeat-containing protein 72 | Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4, ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}. |
| Q3ZCM7 | TUBB8 | S278 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q53HL2 | CDCA8 | S244 | ochoa | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
| Q5T5Y3 | CAMSAP1 | S1239 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TH69 | ARFGEF3 | S468 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VT25 | CDC42BPA | S940 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q68DQ2 | CRYBG3 | S618 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6PJT7 | ZC3H14 | S281 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6R327 | RICTOR | S1174 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6WCQ1 | MPRIP | S891 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q7Z3F1 | GPR155 | S741 | ochoa | Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22) | Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (PubMed:36007018, PubMed:39358511). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018). Binds indole-3-acetic acid and may play a role in tryptophan metabolism (PubMed:39358511). {ECO:0000269|PubMed:36007018, ECO:0000269|PubMed:39358511}. |
| Q7Z7G8 | VPS13B | S105 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86SQ7 | SDCCAG8 | S92 | ochoa | Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) | Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}. |
| Q86V15 | CASZ1 | S720 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86V48 | LUZP1 | S59 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8N1G2 | CMTR1 | S121 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N2G6 | ZCCHC24 | S65 | ochoa | Zinc finger CCHC domain-containing protein 24 | None |
| Q8N3E9 | PLCD3 | S573 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}. |
| Q8NB90 | AFG2A | S250 | ochoa | ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q8NCE0 | TSEN2 | S205 | ochoa | tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. {ECO:0000269|PubMed:15109492}. |
| Q8NI08 | NCOA7 | S608 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TBA6 | GOLGA5 | S460 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TC05 | MDM1 | S683 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8WUY3 | PRUNE2 | S1613 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WVV4 | POF1B | S90 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WXE1 | ATRIP | S512 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WZ82 | OVCA2 | S161 | ochoa | Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase domain-containing protein) (Ovarian cancer-associated gene 2 protein) | Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons. {ECO:0000269|PubMed:32182256}. |
| Q92844 | TANK | S178 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q96L93 | KIF16B | S398 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96P20 | NLRP3 | S735 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q99576 | TSC22D3 | S111 | ochoa | TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7, ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210}.; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000250|UniProtKB:Q9Z2S7}. |
| Q9BQE3 | TUBA1C | S237 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BQL6 | FERMT1 | S502 | ochoa | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}. |
| Q9BSC4 | NOL10 | S603 | ochoa | Nucleolar protein 10 | None |
| Q9BTC0 | DIDO1 | S203 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUF5 | TUBB6 | S278 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S278 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BVJ6 | UTP14A | S445 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BWM7 | SFXN3 | S290 | ochoa | Sideroflexin-3 | Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). {ECO:0000269|PubMed:30442778}. |
| Q9BX63 | BRIP1 | S505 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXW9 | FANCD2 | S1401 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9GZY8 | MFF | S258 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H2H9 | SLC38A1 | S25 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
| Q9H2K8 | TAOK3 | S442 | ochoa | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
| Q9H582 | ZNF644 | S1186 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H814 | PHAX | S149 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9H853 | TUBA4B | S176 | ochoa | Tubulin-like protein alpha-4B (EC 3.6.5.-) (Alpha-tubulin 4B) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed ofalpha- and beta-tubulin heterodimers. {ECO:0000250|UniProtKB:P68363}. |
| Q9HC07 | TMEM165 | S221 | ochoa | Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL) | Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity) (PubMed:22683087, PubMed:23569283, PubMed:27008884, PubMed:32047108). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated. {ECO:0000250|UniProtKB:P38301, ECO:0000250|UniProtKB:P52875, ECO:0000269|PubMed:22683087, ECO:0000269|PubMed:23569283, ECO:0000269|PubMed:27008884, ECO:0000269|PubMed:32047108}. |
| Q9HCM4 | EPB41L5 | S517 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NRS6 | SNX15 | S201 | ochoa | Sorting nexin-15 | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}. |
| Q9NRY4 | ARHGAP35 | S770 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NY65 | TUBA8 | S237 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9P0U4 | CXXC1 | S514 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P1Y6 | PHRF1 | S98 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9UBP0 | SPAST | S207 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
| Q9UJ83 | HACL1 | S192 | ochoa | 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) | Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}. |
| Q9UKX2 | MYH2 | S954 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UNS1 | TIMELESS | S126 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9UPZ3 | HPS5 | S432 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9Y2G0 | EFR3B | S689 | ochoa | Protein EFR3 homolog B | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}. |
| Q9Y446 | PKP3 | S196 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y623 | MYH4 | S952 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6B6 | SAR1B | S162 | ochoa | Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B) | Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII (PubMed:23433038, PubMed:32358066, PubMed:33186557, PubMed:36369712). The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:23433038, PubMed:32358066, PubMed:33186557). In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis (PubMed:32358066, PubMed:33186557). In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B (PubMed:34290409). {ECO:0000269|PubMed:23433038, ECO:0000269|PubMed:32358066, ECO:0000269|PubMed:33186557, ECO:0000269|PubMed:34290409, ECO:0000269|PubMed:36369712}. |
| P33991 | MCM4 | S464 | Sugiyama | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q6ULP2 | AFTPH | S332 | Sugiyama | Aftiphilin | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| P02786 | TFRC | S654 | Sugiyama | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| P09769 | FGR | S418 | Sugiyama | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| Q86XZ4 | SPATS2 | S166 | Sugiyama | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q14195 | DPYSL3 | S30 | Sugiyama | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}. |
| Q16555 | DPYSL2 | S30 | Sugiyama | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q14315 | FLNC | S2246 | GPS6 | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| P53618 | COPB1 | S474 | Sugiyama | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}. |
| P05362 | ICAM1 | S444 | Sugiyama | Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}. |
| P51957 | NEK4 | S723 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q15785 | TOMM34 | S51 | Sugiyama | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| P20020 | ATP2B1 | S52 | Sugiyama | Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) | Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511, ECO:0000269|PubMed:35358416}. |
| Q5S007 | LRRK2 | S1403 | SIGNOR|EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| P13489 | RNH1 | S50 | Sugiyama | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}. |
| P49748 | ACADVL | S489 | Sugiyama | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P62979 | RPS27A | S115 | Sugiyama | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| Q8N4X5 | AFAP1L2 | S711 | Sugiyama | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q96R06 | SPAG5 | S716 | Sugiyama | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q8NHP8 | PLBD2 | S201 | Sugiyama | Putative phospholipase B-like 2 (EC 3.1.1.-) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form] | Putative phospholipase. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.887379e-15 | 14.724 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.221245e-14 | 13.913 |
| R-HSA-9646399 | Aggrephagy | 2.020606e-14 | 13.695 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.408385e-14 | 13.467 |
| R-HSA-983189 | Kinesins | 1.032507e-13 | 12.986 |
| R-HSA-190861 | Gap junction assembly | 1.080247e-13 | 12.966 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.519895e-13 | 12.818 |
| R-HSA-437239 | Recycling pathway of L1 | 1.443290e-13 | 12.841 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 6.081802e-13 | 12.216 |
| R-HSA-190828 | Gap junction trafficking | 1.678213e-12 | 11.775 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.193890e-12 | 11.496 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.024470e-12 | 11.519 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.024470e-12 | 11.519 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.133938e-12 | 11.504 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.585354e-12 | 11.445 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.807377e-12 | 11.318 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 7.855716e-12 | 11.105 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.120926e-11 | 10.950 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.505951e-11 | 10.822 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.725875e-11 | 10.564 |
| R-HSA-69275 | G2/M Transition | 4.002498e-11 | 10.398 |
| R-HSA-373760 | L1CAM interactions | 4.472711e-11 | 10.349 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.674072e-11 | 10.330 |
| R-HSA-2132295 | MHC class II antigen presentation | 9.167511e-11 | 10.038 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.228108e-10 | 9.911 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.344176e-10 | 9.872 |
| R-HSA-9663891 | Selective autophagy | 1.522925e-10 | 9.817 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.954086e-10 | 9.709 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.944279e-10 | 9.711 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.619727e-10 | 9.582 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.573314e-10 | 9.590 |
| R-HSA-68882 | Mitotic Anaphase | 3.722780e-10 | 9.429 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.977881e-10 | 9.400 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.987435e-10 | 9.302 |
| R-HSA-9833482 | PKR-mediated signaling | 6.493859e-10 | 9.187 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.881928e-10 | 9.103 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.465011e-10 | 9.024 |
| R-HSA-68877 | Mitotic Prometaphase | 4.262486e-09 | 8.370 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.689842e-09 | 8.175 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.586132e-09 | 8.120 |
| R-HSA-422475 | Axon guidance | 9.395953e-09 | 8.027 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.644389e-09 | 8.016 |
| R-HSA-9675108 | Nervous system development | 3.192253e-08 | 7.496 |
| R-HSA-1632852 | Macroautophagy | 4.741028e-08 | 7.324 |
| R-HSA-68886 | M Phase | 5.054303e-08 | 7.296 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.869716e-08 | 7.231 |
| R-HSA-1640170 | Cell Cycle | 8.358193e-08 | 7.078 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.245186e-07 | 6.905 |
| R-HSA-9612973 | Autophagy | 1.418856e-07 | 6.848 |
| R-HSA-5617833 | Cilium Assembly | 1.725294e-07 | 6.763 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.113477e-07 | 6.675 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.188277e-07 | 6.496 |
| R-HSA-5620924 | Intraflagellar transport | 3.470956e-07 | 6.460 |
| R-HSA-391251 | Protein folding | 3.654020e-07 | 6.437 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.793567e-07 | 6.108 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.254114e-06 | 5.902 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.371193e-06 | 5.472 |
| R-HSA-913531 | Interferon Signaling | 4.832828e-06 | 5.316 |
| R-HSA-2262752 | Cellular responses to stress | 7.936511e-06 | 5.100 |
| R-HSA-9609690 | HCMV Early Events | 8.411176e-06 | 5.075 |
| R-HSA-199991 | Membrane Trafficking | 9.638699e-06 | 5.016 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.142492e-05 | 4.942 |
| R-HSA-373753 | Nephrin family interactions | 1.191168e-05 | 4.924 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.428814e-05 | 4.845 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.575018e-05 | 4.803 |
| R-HSA-109582 | Hemostasis | 1.842660e-05 | 4.735 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.306943e-05 | 4.366 |
| R-HSA-112316 | Neuronal System | 5.361507e-05 | 4.271 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.865912e-05 | 4.163 |
| R-HSA-9609646 | HCMV Infection | 7.536786e-05 | 4.123 |
| R-HSA-390522 | Striated Muscle Contraction | 1.088081e-04 | 3.963 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.657947e-04 | 3.780 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.225273e-04 | 3.653 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 7.265208e-04 | 3.139 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.012695e-03 | 2.995 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.226574e-03 | 2.911 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.124490e-03 | 2.949 |
| R-HSA-69481 | G2/M Checkpoints | 1.350226e-03 | 2.870 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.443836e-03 | 2.840 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.443836e-03 | 2.840 |
| R-HSA-373755 | Semaphorin interactions | 1.443836e-03 | 2.840 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.473000e-03 | 2.832 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.727902e-03 | 2.762 |
| R-HSA-1500931 | Cell-Cell communication | 1.829259e-03 | 2.738 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.547626e-03 | 2.594 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.765573e-03 | 2.558 |
| R-HSA-380287 | Centrosome maturation | 2.826249e-03 | 2.549 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.390626e-03 | 2.470 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.539718e-03 | 2.451 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.596463e-03 | 2.444 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.794228e-03 | 2.421 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.018132e-03 | 2.299 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.979472e-03 | 2.303 |
| R-HSA-8863678 | Neurodegenerative Diseases | 5.138800e-03 | 2.289 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 5.138800e-03 | 2.289 |
| R-HSA-1266738 | Developmental Biology | 5.231860e-03 | 2.281 |
| R-HSA-397014 | Muscle contraction | 5.564146e-03 | 2.255 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.902338e-03 | 2.229 |
| R-HSA-162582 | Signal Transduction | 6.584227e-03 | 2.181 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 6.671754e-03 | 2.176 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 7.234249e-03 | 2.141 |
| R-HSA-622312 | Inflammasomes | 7.236676e-03 | 2.140 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 7.829115e-03 | 2.106 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 9.779522e-03 | 2.010 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.024458e-02 | 1.990 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.047966e-02 | 1.980 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.080551e-02 | 1.966 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.121716e-02 | 1.950 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.145930e-02 | 1.941 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.197677e-02 | 1.922 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.197677e-02 | 1.922 |
| R-HSA-9824446 | Viral Infection Pathways | 1.220716e-02 | 1.913 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.224733e-02 | 1.912 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.276899e-02 | 1.894 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.305736e-02 | 1.884 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.305736e-02 | 1.884 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.305736e-02 | 1.884 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.305736e-02 | 1.884 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.474642e-02 | 1.831 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.508212e-02 | 1.822 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.532216e-02 | 1.815 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.545526e-02 | 1.811 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.545526e-02 | 1.811 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.632248e-02 | 1.787 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.652423e-02 | 1.782 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.719712e-02 | 1.765 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.847037e-02 | 1.734 |
| R-HSA-5693538 | Homology Directed Repair | 1.848138e-02 | 1.733 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.033729e-02 | 1.692 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.033729e-02 | 1.692 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.033729e-02 | 1.692 |
| R-HSA-5663205 | Infectious disease | 2.037746e-02 | 1.691 |
| R-HSA-1280218 | Adaptive Immune System | 2.053419e-02 | 1.688 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.459220e-02 | 1.609 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.447930e-02 | 1.611 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.344220e-02 | 1.630 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 2.459220e-02 | 1.609 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 2.459220e-02 | 1.609 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.447930e-02 | 1.611 |
| R-HSA-114608 | Platelet degranulation | 2.434840e-02 | 1.614 |
| R-HSA-9675135 | Diseases of DNA repair | 2.459220e-02 | 1.609 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.427807e-02 | 1.615 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.509892e-02 | 1.600 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.593635e-02 | 1.586 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.666844e-02 | 1.574 |
| R-HSA-9031628 | NGF-stimulated transcription | 2.698221e-02 | 1.569 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.909689e-02 | 1.536 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.945306e-02 | 1.531 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.079153e-02 | 1.512 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.212087e-02 | 1.493 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.212087e-02 | 1.493 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.212087e-02 | 1.493 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.323920e-02 | 1.478 |
| R-HSA-1221632 | Meiotic synapsis | 3.347984e-02 | 1.475 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.370153e-02 | 1.472 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.921000e-02 | 1.407 |
| R-HSA-70171 | Glycolysis | 3.942811e-02 | 1.404 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.133173e-02 | 1.384 |
| R-HSA-5689901 | Metalloprotease DUBs | 5.242508e-02 | 1.280 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.956099e-02 | 1.305 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.236927e-02 | 1.281 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.236927e-02 | 1.281 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.623134e-02 | 1.335 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.765175e-02 | 1.322 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.516646e-02 | 1.345 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.867332e-02 | 1.313 |
| R-HSA-8848021 | Signaling by PTK6 | 4.867332e-02 | 1.313 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.742492e-02 | 1.324 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 5.534681e-02 | 1.257 |
| R-HSA-75157 | FasL/ CD95L signaling | 5.553919e-02 | 1.255 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 7.688595e-02 | 1.114 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 8.737868e-02 | 1.059 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 8.737868e-02 | 1.059 |
| R-HSA-5263617 | Metabolism of ingested MeSeO2H into MeSeH | 9.775279e-02 | 1.010 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.181504e-01 | 0.928 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.181504e-01 | 0.928 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.281766e-01 | 0.892 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.281766e-01 | 0.892 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.478901e-01 | 0.830 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 6.757743e-02 | 1.170 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.044097e-01 | 0.689 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.044097e-01 | 0.689 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 8.060264e-02 | 1.094 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.134601e-01 | 0.671 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.134601e-01 | 0.671 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.273248e-01 | 0.895 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.058393e-02 | 1.151 |
| R-HSA-72649 | Translation initiation complex formation | 1.585469e-01 | 0.800 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.665630e-01 | 0.778 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.665630e-01 | 0.778 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.746481e-01 | 0.758 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.033879e-01 | 0.692 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.508965e-01 | 0.821 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.197711e-01 | 0.922 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.380894e-01 | 0.860 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.952556e-01 | 0.709 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 8.737868e-02 | 1.059 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.281766e-01 | 0.892 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.859968e-01 | 0.730 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.952556e-01 | 0.709 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 7.727714e-02 | 1.112 |
| R-HSA-6798695 | Neutrophil degranulation | 9.923524e-02 | 1.003 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.766321e-01 | 0.753 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.943611e-02 | 1.048 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.014253e-01 | 0.994 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 6.627324e-02 | 1.179 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 9.775279e-02 | 1.010 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.080096e-01 | 0.967 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.080096e-01 | 0.967 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 8.397187e-02 | 1.076 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 8.397187e-02 | 1.076 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.086654e-01 | 0.964 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.311432e-01 | 0.882 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.506071e-01 | 0.822 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.545669e-01 | 0.811 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.545669e-01 | 0.811 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.671602e-01 | 0.777 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.625459e-01 | 0.789 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.766321e-01 | 0.753 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.859968e-01 | 0.730 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.666714e-02 | 1.176 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.506071e-01 | 0.822 |
| R-HSA-9033241 | Peroxisomal protein import | 1.787143e-01 | 0.748 |
| R-HSA-4641258 | Degradation of DVL | 9.083586e-02 | 1.042 |
| R-HSA-9907900 | Proteasome assembly | 1.197711e-01 | 0.922 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.665630e-01 | 0.778 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.617520e-01 | 0.791 |
| R-HSA-75158 | TRAIL signaling | 8.737868e-02 | 1.059 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.080096e-01 | 0.967 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.080096e-01 | 0.967 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.181504e-01 | 0.928 |
| R-HSA-176974 | Unwinding of DNA | 1.281766e-01 | 0.892 |
| R-HSA-5689877 | Josephin domain DUBs | 1.380894e-01 | 0.860 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.766321e-01 | 0.753 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.952556e-01 | 0.709 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 8.738340e-02 | 1.059 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 8.738340e-02 | 1.059 |
| R-HSA-4641257 | Degradation of AXIN | 9.083586e-02 | 1.042 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 9.083586e-02 | 1.042 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 2.224082e-01 | 0.653 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.086654e-01 | 0.964 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.474745e-02 | 1.189 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.585469e-01 | 0.800 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.273248e-01 | 0.895 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 7.399678e-02 | 1.131 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.545669e-01 | 0.811 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.134601e-01 | 0.671 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.859968e-01 | 0.730 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 9.785816e-02 | 1.009 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.733232e-02 | 1.242 |
| R-HSA-6799198 | Complex I biogenesis | 1.951161e-01 | 0.710 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.311432e-01 | 0.882 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.181504e-01 | 0.928 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.478901e-01 | 0.830 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 7.727714e-02 | 1.112 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 8.060264e-02 | 1.094 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 8.060264e-02 | 1.094 |
| R-HSA-169911 | Regulation of Apoptosis | 8.397187e-02 | 1.076 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.086654e-01 | 0.964 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.086654e-01 | 0.964 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.427513e-01 | 0.845 |
| R-HSA-75893 | TNF signaling | 1.665630e-01 | 0.778 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.149819e-01 | 0.939 |
| R-HSA-69306 | DNA Replication | 1.336710e-01 | 0.874 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 9.432789e-02 | 1.025 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.952556e-01 | 0.709 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.235338e-01 | 0.908 |
| R-HSA-9729555 | Sensory perception of sour taste | 6.627324e-02 | 1.179 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.181504e-01 | 0.928 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.181504e-01 | 0.928 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.575799e-01 | 0.802 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.575799e-01 | 0.802 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.671602e-01 | 0.777 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.671602e-01 | 0.777 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.952556e-01 | 0.709 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 8.060264e-02 | 1.094 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.014253e-01 | 0.994 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.014253e-01 | 0.994 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.050282e-01 | 0.979 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.050282e-01 | 0.979 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.098669e-02 | 1.215 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.273248e-01 | 0.895 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.466682e-01 | 0.834 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.746481e-01 | 0.758 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.590160e-01 | 0.799 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.237701e-01 | 0.907 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.545669e-01 | 0.811 |
| R-HSA-9659379 | Sensory processing of sound | 7.872012e-02 | 1.104 |
| R-HSA-9766229 | Degradation of CDH1 | 1.388575e-01 | 0.857 |
| R-HSA-69239 | Synthesis of DNA | 1.562945e-01 | 0.806 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.376779e-01 | 0.861 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 9.775279e-02 | 1.010 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.160381e-01 | 0.935 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.197711e-01 | 0.922 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.235338e-01 | 0.908 |
| R-HSA-73894 | DNA Repair | 7.176604e-02 | 1.144 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.203537e-01 | 0.657 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 8.738340e-02 | 1.059 |
| R-HSA-69541 | Stabilization of p53 | 9.785816e-02 | 1.009 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.455604e-01 | 0.837 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 7.688595e-02 | 1.114 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 8.737868e-02 | 1.059 |
| R-HSA-389542 | NADPH regeneration | 9.775279e-02 | 1.010 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.671602e-01 | 0.777 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.671602e-01 | 0.777 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 1.671602e-01 | 0.777 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.671602e-01 | 0.777 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.859968e-01 | 0.730 |
| R-HSA-9857492 | Protein lipoylation | 1.952556e-01 | 0.709 |
| R-HSA-1500620 | Meiosis | 9.164935e-02 | 1.038 |
| R-HSA-202424 | Downstream TCR signaling | 1.053952e-01 | 0.977 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.274074e-01 | 0.895 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.248846e-01 | 0.903 |
| R-HSA-597592 | Post-translational protein modification | 6.869534e-02 | 1.163 |
| R-HSA-917937 | Iron uptake and transport | 7.058393e-02 | 1.151 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.868894e-01 | 0.728 |
| R-HSA-69242 | S Phase | 1.237701e-01 | 0.907 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 9.785816e-02 | 1.009 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.160381e-01 | 0.935 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.050282e-01 | 0.979 |
| R-HSA-2559585 | Oncogene Induced Senescence | 8.397187e-02 | 1.076 |
| R-HSA-5218859 | Regulated Necrosis | 2.158666e-01 | 0.666 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 7.688595e-02 | 1.114 |
| R-HSA-9683683 | Maturation of protein E | 8.737868e-02 | 1.059 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.737868e-02 | 1.059 |
| R-HSA-9694493 | Maturation of protein E | 8.737868e-02 | 1.059 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.080096e-01 | 0.967 |
| R-HSA-448706 | Interleukin-1 processing | 1.281766e-01 | 0.892 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.281766e-01 | 0.892 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.478901e-01 | 0.830 |
| R-HSA-8963888 | Chylomicron assembly | 1.478901e-01 | 0.830 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.134601e-01 | 0.671 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 8.943611e-02 | 1.048 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.033879e-01 | 0.692 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 2.242247e-01 | 0.649 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.952556e-01 | 0.709 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.044097e-01 | 0.689 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.235338e-01 | 0.908 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.235338e-01 | 0.908 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 1.273248e-01 | 0.895 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.388575e-01 | 0.857 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.388575e-01 | 0.857 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.951161e-01 | 0.710 |
| R-HSA-69206 | G1/S Transition | 7.792823e-02 | 1.108 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.445634e-01 | 0.840 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.181504e-01 | 0.928 |
| R-HSA-180024 | DARPP-32 events | 6.135661e-02 | 1.212 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.585469e-01 | 0.800 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.554503e-01 | 0.808 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.474745e-02 | 1.189 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.506071e-01 | 0.822 |
| R-HSA-9664873 | Pexophagy | 1.380894e-01 | 0.860 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.098669e-02 | 1.215 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 7.399678e-02 | 1.131 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 2.224082e-01 | 0.653 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.909967e-01 | 0.719 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.466682e-01 | 0.834 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.242247e-01 | 0.649 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.199012e-01 | 0.921 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.181504e-01 | 0.928 |
| R-HSA-9708530 | Regulation of BACH1 activity | 2.044097e-01 | 0.689 |
| R-HSA-5357801 | Programmed Cell Death | 1.170955e-01 | 0.931 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.242247e-01 | 0.649 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.841292e-01 | 0.735 |
| R-HSA-69236 | G1 Phase | 1.197711e-01 | 0.922 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.197711e-01 | 0.922 |
| R-HSA-168256 | Immune System | 7.279119e-02 | 1.138 |
| R-HSA-9909396 | Circadian clock | 9.096452e-02 | 1.041 |
| R-HSA-202403 | TCR signaling | 1.645024e-01 | 0.784 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.671602e-01 | 0.777 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.956125e-01 | 0.709 |
| R-HSA-2559583 | Cellular Senescence | 1.944440e-01 | 0.711 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.625459e-01 | 0.789 |
| R-HSA-9658195 | Leishmania infection | 1.325727e-01 | 0.878 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.325727e-01 | 0.878 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.841292e-01 | 0.735 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.281766e-01 | 0.892 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.380894e-01 | 0.860 |
| R-HSA-3229121 | Glycogen storage diseases | 2.224082e-01 | 0.653 |
| R-HSA-70326 | Glucose metabolism | 6.448024e-02 | 1.191 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 1.316652e-01 | 0.881 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.066853e-02 | 1.151 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.066853e-02 | 1.151 |
| R-HSA-70268 | Pyruvate metabolism | 9.842405e-02 | 1.007 |
| R-HSA-194138 | Signaling by VEGF | 2.161098e-01 | 0.665 |
| R-HSA-109581 | Apoptosis | 5.687765e-02 | 1.245 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 8.060264e-02 | 1.094 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.044097e-01 | 0.689 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.861271e-02 | 1.164 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.872012e-02 | 1.104 |
| R-HSA-1643685 | Disease | 1.288201e-01 | 0.890 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.017571e-01 | 0.992 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 7.727714e-02 | 1.112 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.705974e-01 | 0.768 |
| R-HSA-446728 | Cell junction organization | 5.647789e-02 | 1.248 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.506071e-01 | 0.822 |
| R-HSA-418990 | Adherens junctions interactions | 1.385676e-01 | 0.858 |
| R-HSA-421270 | Cell-cell junction organization | 1.998778e-01 | 0.699 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.014253e-01 | 0.994 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 7.076305e-02 | 1.150 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.830025e-01 | 0.738 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.478901e-01 | 0.830 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.951161e-01 | 0.710 |
| R-HSA-75153 | Apoptotic execution phase | 1.273248e-01 | 0.895 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.224920e-01 | 0.912 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.049731e-01 | 0.979 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.250310e-01 | 0.648 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.284132e-01 | 0.641 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.284132e-01 | 0.641 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.284132e-01 | 0.641 |
| R-HSA-3928664 | Ephrin signaling | 2.312551e-01 | 0.636 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.312551e-01 | 0.636 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.312551e-01 | 0.636 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.312551e-01 | 0.636 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.312551e-01 | 0.636 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.312551e-01 | 0.636 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.312551e-01 | 0.636 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 2.312551e-01 | 0.636 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.312551e-01 | 0.636 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.312551e-01 | 0.636 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.326072e-01 | 0.633 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.326072e-01 | 0.633 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.330778e-01 | 0.632 |
| R-HSA-1474165 | Reproduction | 2.340232e-01 | 0.631 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.400018e-01 | 0.620 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.400018e-01 | 0.620 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.400018e-01 | 0.620 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.400018e-01 | 0.620 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.400018e-01 | 0.620 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.400018e-01 | 0.620 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.410089e-01 | 0.618 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.442639e-01 | 0.612 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.452153e-01 | 0.610 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.486495e-01 | 0.604 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.486495e-01 | 0.604 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.486495e-01 | 0.604 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.486495e-01 | 0.604 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.486495e-01 | 0.604 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.486495e-01 | 0.604 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.486495e-01 | 0.604 |
| R-HSA-3322077 | Glycogen synthesis | 2.486495e-01 | 0.604 |
| R-HSA-5689603 | UCH proteinases | 2.494247e-01 | 0.603 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.495918e-01 | 0.603 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.536363e-01 | 0.596 |
| R-HSA-163685 | Integration of energy metabolism | 2.552408e-01 | 0.593 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.571994e-01 | 0.590 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.571994e-01 | 0.590 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.571994e-01 | 0.590 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 2.571994e-01 | 0.590 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.571994e-01 | 0.590 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 2.571994e-01 | 0.590 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.571994e-01 | 0.590 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.571994e-01 | 0.590 |
| R-HSA-5619084 | ABC transporter disorders | 2.578496e-01 | 0.589 |
| R-HSA-4086400 | PCP/CE pathway | 2.578496e-01 | 0.589 |
| R-HSA-6783783 | Interleukin-10 signaling | 2.578496e-01 | 0.589 |
| R-HSA-212436 | Generic Transcription Pathway | 2.586544e-01 | 0.587 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.613542e-01 | 0.583 |
| R-HSA-6807070 | PTEN Regulation | 2.644181e-01 | 0.578 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.656525e-01 | 0.576 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.656525e-01 | 0.576 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.656525e-01 | 0.576 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.656525e-01 | 0.576 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.656525e-01 | 0.576 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.656525e-01 | 0.576 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.656525e-01 | 0.576 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.656525e-01 | 0.576 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.656525e-01 | 0.576 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.662790e-01 | 0.575 |
| R-HSA-9664407 | Parasite infection | 2.674866e-01 | 0.573 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.674866e-01 | 0.573 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.674866e-01 | 0.573 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.740099e-01 | 0.562 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.740099e-01 | 0.562 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.740099e-01 | 0.562 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.747084e-01 | 0.561 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.767166e-01 | 0.558 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.789218e-01 | 0.555 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.798006e-01 | 0.553 |
| R-HSA-168249 | Innate Immune System | 2.818509e-01 | 0.550 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.822727e-01 | 0.549 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.822727e-01 | 0.549 |
| R-HSA-200425 | Carnitine shuttle | 2.822727e-01 | 0.549 |
| R-HSA-3000170 | Syndecan interactions | 2.822727e-01 | 0.549 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.822727e-01 | 0.549 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.828880e-01 | 0.548 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.873433e-01 | 0.542 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.873433e-01 | 0.542 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.873433e-01 | 0.542 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.904420e-01 | 0.537 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.904420e-01 | 0.537 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.904420e-01 | 0.537 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.904420e-01 | 0.537 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.915504e-01 | 0.535 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.915504e-01 | 0.535 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.915504e-01 | 0.535 |
| R-HSA-166520 | Signaling by NTRKs | 2.952657e-01 | 0.530 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.985187e-01 | 0.525 |
| R-HSA-9620244 | Long-term potentiation | 2.985187e-01 | 0.525 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.985187e-01 | 0.525 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.985187e-01 | 0.525 |
| R-HSA-389599 | Alpha-oxidation of phytanate | 2.985187e-01 | 0.525 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.012000e-01 | 0.521 |
| R-HSA-156902 | Peptide chain elongation | 3.041514e-01 | 0.517 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.065041e-01 | 0.514 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.065041e-01 | 0.514 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.065041e-01 | 0.514 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.065041e-01 | 0.514 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.076777e-01 | 0.512 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.076777e-01 | 0.512 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.083434e-01 | 0.511 |
| R-HSA-73887 | Death Receptor Signaling | 3.138921e-01 | 0.503 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.143990e-01 | 0.503 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.143990e-01 | 0.503 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.143990e-01 | 0.503 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 3.143990e-01 | 0.503 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.143990e-01 | 0.503 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.143990e-01 | 0.503 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.143990e-01 | 0.503 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.143990e-01 | 0.503 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.152881e-01 | 0.501 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.157519e-01 | 0.501 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.167123e-01 | 0.499 |
| R-HSA-1989781 | PPARA activates gene expression | 3.170007e-01 | 0.499 |
| R-HSA-449147 | Signaling by Interleukins | 3.200651e-01 | 0.495 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.208884e-01 | 0.494 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.222046e-01 | 0.492 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.222046e-01 | 0.492 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.222046e-01 | 0.492 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.222046e-01 | 0.492 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.222046e-01 | 0.492 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.232195e-01 | 0.491 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.250584e-01 | 0.488 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.250584e-01 | 0.488 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.250584e-01 | 0.488 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.263293e-01 | 0.486 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.299217e-01 | 0.482 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.299217e-01 | 0.482 |
| R-HSA-72086 | mRNA Capping | 3.299217e-01 | 0.482 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.299217e-01 | 0.482 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.299217e-01 | 0.482 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.299217e-01 | 0.482 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.299217e-01 | 0.482 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.325487e-01 | 0.478 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.375274e-01 | 0.472 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 3.375274e-01 | 0.472 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.375515e-01 | 0.472 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.375515e-01 | 0.472 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.375515e-01 | 0.472 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.416689e-01 | 0.466 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.416689e-01 | 0.466 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.416689e-01 | 0.466 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.449810e-01 | 0.462 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.450948e-01 | 0.462 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.450948e-01 | 0.462 |
| R-HSA-182971 | EGFR downregulation | 3.450948e-01 | 0.462 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.450948e-01 | 0.462 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.450948e-01 | 0.462 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.499274e-01 | 0.456 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.525527e-01 | 0.453 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.525527e-01 | 0.453 |
| R-HSA-69190 | DNA strand elongation | 3.525527e-01 | 0.453 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.540437e-01 | 0.451 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.540437e-01 | 0.451 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.540437e-01 | 0.451 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.581509e-01 | 0.446 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.599262e-01 | 0.444 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.599262e-01 | 0.444 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.599262e-01 | 0.444 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.599262e-01 | 0.444 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.622488e-01 | 0.441 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.622488e-01 | 0.441 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.663370e-01 | 0.436 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.666852e-01 | 0.436 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.672161e-01 | 0.435 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.672161e-01 | 0.435 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.672161e-01 | 0.435 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.672161e-01 | 0.435 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.697774e-01 | 0.432 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.728670e-01 | 0.428 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.744234e-01 | 0.427 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.744234e-01 | 0.427 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.744234e-01 | 0.427 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.744234e-01 | 0.427 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.744234e-01 | 0.427 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.744234e-01 | 0.427 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.744234e-01 | 0.427 |
| R-HSA-5205647 | Mitophagy | 3.744234e-01 | 0.427 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 3.744829e-01 | 0.427 |
| R-HSA-192823 | Viral mRNA Translation | 3.744829e-01 | 0.427 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.759539e-01 | 0.425 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.785401e-01 | 0.422 |
| R-HSA-111885 | Opioid Signalling | 3.785401e-01 | 0.422 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.790377e-01 | 0.421 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 3.815491e-01 | 0.418 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.815491e-01 | 0.418 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.815491e-01 | 0.418 |
| R-HSA-5688426 | Deubiquitination | 3.848774e-01 | 0.415 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.874514e-01 | 0.412 |
| R-HSA-8853659 | RET signaling | 3.885941e-01 | 0.411 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.885941e-01 | 0.411 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.885941e-01 | 0.411 |
| R-HSA-163560 | Triglyceride catabolism | 3.885941e-01 | 0.411 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.885941e-01 | 0.411 |
| R-HSA-418346 | Platelet homeostasis | 3.906454e-01 | 0.408 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.946574e-01 | 0.404 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.946574e-01 | 0.404 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.946574e-01 | 0.404 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.955592e-01 | 0.403 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.955592e-01 | 0.403 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.955592e-01 | 0.403 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.955592e-01 | 0.403 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.955592e-01 | 0.403 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.986575e-01 | 0.399 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.986575e-01 | 0.399 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.986575e-01 | 0.399 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.986575e-01 | 0.399 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.986575e-01 | 0.399 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.026454e-01 | 0.395 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.092536e-01 | 0.388 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.092536e-01 | 0.388 |
| R-HSA-71336 | Pentose phosphate pathway | 4.092536e-01 | 0.388 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.092536e-01 | 0.388 |
| R-HSA-9648002 | RAS processing | 4.092536e-01 | 0.388 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.092536e-01 | 0.388 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.092536e-01 | 0.388 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.145335e-01 | 0.382 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.145335e-01 | 0.382 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.159847e-01 | 0.381 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.159847e-01 | 0.381 |
| R-HSA-167169 | HIV Transcription Elongation | 4.159847e-01 | 0.381 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.159847e-01 | 0.381 |
| R-HSA-5260271 | Diseases of Immune System | 4.159847e-01 | 0.381 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.159847e-01 | 0.381 |
| R-HSA-8982491 | Glycogen metabolism | 4.159847e-01 | 0.381 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.184703e-01 | 0.378 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.218122e-01 | 0.375 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.226394e-01 | 0.374 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.226394e-01 | 0.374 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.226394e-01 | 0.374 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.226394e-01 | 0.374 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.226394e-01 | 0.374 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.226394e-01 | 0.374 |
| R-HSA-9607240 | FLT3 Signaling | 4.226394e-01 | 0.374 |
| R-HSA-983712 | Ion channel transport | 4.248330e-01 | 0.372 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.292188e-01 | 0.367 |
| R-HSA-167161 | HIV Transcription Initiation | 4.292188e-01 | 0.367 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.292188e-01 | 0.367 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.292188e-01 | 0.367 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.292188e-01 | 0.367 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.292188e-01 | 0.367 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.292188e-01 | 0.367 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.292188e-01 | 0.367 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.301998e-01 | 0.366 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.301998e-01 | 0.366 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.357235e-01 | 0.361 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.357235e-01 | 0.361 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.379502e-01 | 0.359 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.379502e-01 | 0.359 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.421545e-01 | 0.354 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.421545e-01 | 0.354 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.421545e-01 | 0.354 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.494682e-01 | 0.347 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.494682e-01 | 0.347 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.547987e-01 | 0.342 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.547987e-01 | 0.342 |
| R-HSA-9824272 | Somitogenesis | 4.547987e-01 | 0.342 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 4.547987e-01 | 0.342 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.576813e-01 | 0.339 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.608531e-01 | 0.336 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.608531e-01 | 0.336 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.610135e-01 | 0.336 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.610135e-01 | 0.336 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.610135e-01 | 0.336 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.610135e-01 | 0.336 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.617265e-01 | 0.336 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.665061e-01 | 0.331 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.671578e-01 | 0.331 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.683669e-01 | 0.329 |
| R-HSA-70263 | Gluconeogenesis | 4.732325e-01 | 0.325 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.732325e-01 | 0.325 |
| R-HSA-73893 | DNA Damage Bypass | 4.792383e-01 | 0.319 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.792383e-01 | 0.319 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.792383e-01 | 0.319 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.858989e-01 | 0.313 |
| R-HSA-9679506 | SARS-CoV Infections | 4.879447e-01 | 0.312 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.968500e-01 | 0.304 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.968500e-01 | 0.304 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.968500e-01 | 0.304 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.025879e-01 | 0.299 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.025879e-01 | 0.299 |
| R-HSA-74160 | Gene expression (Transcription) | 5.100503e-01 | 0.292 |
| R-HSA-392499 | Metabolism of proteins | 5.122725e-01 | 0.290 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.194141e-01 | 0.284 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.194141e-01 | 0.284 |
| R-HSA-177929 | Signaling by EGFR | 5.194141e-01 | 0.284 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.194141e-01 | 0.284 |
| R-HSA-5578775 | Ion homeostasis | 5.194141e-01 | 0.284 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.194141e-01 | 0.284 |
| R-HSA-8951664 | Neddylation | 5.208274e-01 | 0.283 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.226750e-01 | 0.282 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.248961e-01 | 0.280 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.261623e-01 | 0.279 |
| R-HSA-5368287 | Mitochondrial translation | 5.296326e-01 | 0.276 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.346254e-01 | 0.272 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.356742e-01 | 0.271 |
| R-HSA-191859 | snRNP Assembly | 5.356742e-01 | 0.271 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.356742e-01 | 0.271 |
| R-HSA-8979227 | Triglyceride metabolism | 5.356742e-01 | 0.271 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.356742e-01 | 0.271 |
| R-HSA-162906 | HIV Infection | 5.373583e-01 | 0.270 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.399400e-01 | 0.268 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.409716e-01 | 0.267 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.409716e-01 | 0.267 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.409716e-01 | 0.267 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.409716e-01 | 0.267 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.409716e-01 | 0.267 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.409716e-01 | 0.267 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.409716e-01 | 0.267 |
| R-HSA-351202 | Metabolism of polyamines | 5.409716e-01 | 0.267 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.409716e-01 | 0.267 |
| R-HSA-8978868 | Fatty acid metabolism | 5.422421e-01 | 0.266 |
| R-HSA-450294 | MAP kinase activation | 5.462090e-01 | 0.263 |
| R-HSA-211976 | Endogenous sterols | 5.462090e-01 | 0.263 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.462090e-01 | 0.263 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.467250e-01 | 0.262 |
| R-HSA-72312 | rRNA processing | 5.508857e-01 | 0.259 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.513869e-01 | 0.259 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.513869e-01 | 0.259 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.513869e-01 | 0.259 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.565061e-01 | 0.255 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.615671e-01 | 0.251 |
| R-HSA-211981 | Xenobiotics | 5.615671e-01 | 0.251 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.715176e-01 | 0.243 |
| R-HSA-157118 | Signaling by NOTCH | 5.720414e-01 | 0.243 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.731647e-01 | 0.242 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.764082e-01 | 0.239 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.764082e-01 | 0.239 |
| R-HSA-167172 | Transcription of the HIV genome | 5.812434e-01 | 0.236 |
| R-HSA-9609507 | Protein localization | 5.827885e-01 | 0.234 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.859610e-01 | 0.232 |
| R-HSA-72766 | Translation | 5.868024e-01 | 0.232 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.891157e-01 | 0.230 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.907496e-01 | 0.229 |
| R-HSA-448424 | Interleukin-17 signaling | 5.907496e-01 | 0.229 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.907496e-01 | 0.229 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.951461e-01 | 0.225 |
| R-HSA-162587 | HIV Life Cycle | 5.953718e-01 | 0.225 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.954219e-01 | 0.225 |
| R-HSA-8978934 | Metabolism of cofactors | 5.954219e-01 | 0.225 |
| R-HSA-9711097 | Cellular response to starvation | 5.984733e-01 | 0.223 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.000411e-01 | 0.222 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 6.000411e-01 | 0.222 |
| R-HSA-877300 | Interferon gamma signaling | 6.015569e-01 | 0.221 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.046079e-01 | 0.219 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 6.046079e-01 | 0.219 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.091229e-01 | 0.215 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.102191e-01 | 0.215 |
| R-HSA-8852135 | Protein ubiquitination | 6.135865e-01 | 0.212 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 6.135865e-01 | 0.212 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.135865e-01 | 0.212 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.179995e-01 | 0.209 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.179995e-01 | 0.209 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.223623e-01 | 0.206 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.266756e-01 | 0.203 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.266756e-01 | 0.203 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.266756e-01 | 0.203 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 6.266756e-01 | 0.203 |
| R-HSA-216083 | Integrin cell surface interactions | 6.266756e-01 | 0.203 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.351557e-01 | 0.197 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.351557e-01 | 0.197 |
| R-HSA-6806834 | Signaling by MET | 6.351557e-01 | 0.197 |
| R-HSA-977225 | Amyloid fiber formation | 6.393236e-01 | 0.194 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.475179e-01 | 0.189 |
| R-HSA-8953854 | Metabolism of RNA | 6.477289e-01 | 0.189 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 6.515453e-01 | 0.186 |
| R-HSA-611105 | Respiratory electron transport | 6.595160e-01 | 0.181 |
| R-HSA-168255 | Influenza Infection | 6.622299e-01 | 0.179 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.633551e-01 | 0.178 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.729132e-01 | 0.172 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.784845e-01 | 0.168 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.893859e-01 | 0.162 |
| R-HSA-2029481 | FCGR activation | 6.929374e-01 | 0.159 |
| R-HSA-9824439 | Bacterial Infection Pathways | 6.931847e-01 | 0.159 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.959533e-01 | 0.157 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.008886e-01 | 0.154 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.067440e-01 | 0.151 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.067440e-01 | 0.151 |
| R-HSA-5368286 | Mitochondrial translation initiation | 7.134140e-01 | 0.147 |
| R-HSA-190236 | Signaling by FGFR | 7.134140e-01 | 0.147 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.231371e-01 | 0.141 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.263046e-01 | 0.139 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.263046e-01 | 0.139 |
| R-HSA-72172 | mRNA Splicing | 7.268606e-01 | 0.139 |
| R-HSA-9833110 | RSV-host interactions | 7.355927e-01 | 0.133 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.358832e-01 | 0.133 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.503812e-01 | 0.125 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.529734e-01 | 0.123 |
| R-HSA-8957322 | Metabolism of steroids | 7.547212e-01 | 0.122 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.588563e-01 | 0.120 |
| R-HSA-1474244 | Extracellular matrix organization | 7.666806e-01 | 0.115 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.800833e-01 | 0.108 |
| R-HSA-68875 | Mitotic Prophase | 7.850929e-01 | 0.105 |
| R-HSA-3371556 | Cellular response to heat stress | 7.875550e-01 | 0.104 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.875550e-01 | 0.104 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.923953e-01 | 0.101 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.947742e-01 | 0.100 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.994509e-01 | 0.097 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.994509e-01 | 0.097 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.994509e-01 | 0.097 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.017494e-01 | 0.096 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.107883e-01 | 0.091 |
| R-HSA-382551 | Transport of small molecules | 8.140898e-01 | 0.089 |
| R-HSA-9717189 | Sensory perception of taste | 8.150002e-01 | 0.089 |
| R-HSA-9843745 | Adipogenesis | 8.150002e-01 | 0.089 |
| R-HSA-5576891 | Cardiac conduction | 8.150002e-01 | 0.089 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.154568e-01 | 0.089 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.425699e-01 | 0.074 |
| R-HSA-9758941 | Gastrulation | 8.531259e-01 | 0.069 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.575472e-01 | 0.067 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.613447e-01 | 0.065 |
| R-HSA-195721 | Signaling by WNT | 8.800830e-01 | 0.055 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.807017e-01 | 0.055 |
| R-HSA-72306 | tRNA processing | 8.860928e-01 | 0.053 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.899765e-01 | 0.051 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.899765e-01 | 0.051 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.222548e-01 | 0.035 |
| R-HSA-6805567 | Keratinization | 9.257761e-01 | 0.033 |
| R-HSA-556833 | Metabolism of lipids | 9.332370e-01 | 0.030 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.352414e-01 | 0.029 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.364012e-01 | 0.029 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.431541e-01 | 0.025 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.438100e-01 | 0.025 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.463594e-01 | 0.024 |
| R-HSA-15869 | Metabolism of nucleotides | 9.475907e-01 | 0.023 |
| R-HSA-8939211 | ESR-mediated signaling | 9.481957e-01 | 0.023 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.481957e-01 | 0.023 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.532895e-01 | 0.021 |
| R-HSA-4839726 | Chromatin organization | 9.549362e-01 | 0.020 |
| R-HSA-418594 | G alpha (i) signalling events | 9.576135e-01 | 0.019 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.678384e-01 | 0.014 |
| R-HSA-1483257 | Phospholipid metabolism | 9.736161e-01 | 0.012 |
| R-HSA-5668914 | Diseases of metabolism | 9.944369e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.949643e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.977631e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.982062e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.997600e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999712e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.835 | 0.119 | 2 | 0.832 |
CLK3 |
0.830 | 0.158 | 1 | 0.871 |
CDC7 |
0.825 | 0.056 | 1 | 0.877 |
GCN2 |
0.823 | -0.010 | 2 | 0.804 |
MTOR |
0.821 | 0.033 | 1 | 0.815 |
DSTYK |
0.821 | 0.065 | 2 | 0.818 |
ULK2 |
0.820 | -0.011 | 2 | 0.808 |
ATR |
0.820 | 0.097 | 1 | 0.890 |
PRPK |
0.819 | -0.064 | -1 | 0.845 |
NLK |
0.819 | 0.066 | 1 | 0.859 |
MOS |
0.819 | 0.069 | 1 | 0.896 |
CAMK1B |
0.817 | 0.025 | -3 | 0.783 |
NEK6 |
0.817 | 0.042 | -2 | 0.809 |
BMPR2 |
0.816 | 0.038 | -2 | 0.844 |
RAF1 |
0.816 | -0.022 | 1 | 0.852 |
CDKL1 |
0.815 | 0.035 | -3 | 0.734 |
RSK2 |
0.815 | 0.047 | -3 | 0.686 |
PKCD |
0.814 | 0.087 | 2 | 0.794 |
TSSK2 |
0.814 | 0.141 | -5 | 0.879 |
PKN3 |
0.814 | 0.050 | -3 | 0.732 |
TGFBR2 |
0.814 | 0.039 | -2 | 0.804 |
MLK1 |
0.813 | 0.030 | 2 | 0.801 |
IKKB |
0.812 | -0.046 | -2 | 0.706 |
NEK7 |
0.812 | -0.013 | -3 | 0.786 |
PDHK4 |
0.812 | -0.172 | 1 | 0.869 |
NUAK2 |
0.811 | 0.029 | -3 | 0.738 |
PRKD1 |
0.811 | 0.063 | -3 | 0.733 |
ERK5 |
0.811 | 0.031 | 1 | 0.802 |
PIM3 |
0.810 | -0.014 | -3 | 0.743 |
PKN2 |
0.810 | 0.036 | -3 | 0.740 |
CAMK2G |
0.810 | -0.058 | 2 | 0.757 |
TBK1 |
0.810 | -0.056 | 1 | 0.748 |
ULK1 |
0.810 | -0.061 | -3 | 0.774 |
CHAK2 |
0.810 | 0.026 | -1 | 0.789 |
PRKD2 |
0.810 | 0.056 | -3 | 0.665 |
KIS |
0.810 | 0.068 | 1 | 0.741 |
P90RSK |
0.810 | 0.017 | -3 | 0.696 |
MST4 |
0.809 | 0.027 | 2 | 0.788 |
SRPK1 |
0.809 | 0.048 | -3 | 0.687 |
NIK |
0.809 | 0.004 | -3 | 0.796 |
CDKL5 |
0.808 | 0.012 | -3 | 0.725 |
HIPK4 |
0.808 | 0.019 | 1 | 0.838 |
WNK1 |
0.807 | -0.027 | -2 | 0.820 |
CAMLCK |
0.807 | 0.024 | -2 | 0.842 |
PDHK1 |
0.807 | -0.148 | 1 | 0.860 |
IKKE |
0.807 | -0.067 | 1 | 0.743 |
TSSK1 |
0.807 | 0.089 | -3 | 0.767 |
RSK3 |
0.807 | 0.009 | -3 | 0.683 |
BMPR1B |
0.806 | 0.143 | 1 | 0.794 |
ATM |
0.806 | 0.083 | 1 | 0.852 |
IRE1 |
0.806 | 0.031 | 1 | 0.811 |
IRE2 |
0.806 | 0.064 | 2 | 0.817 |
AMPKA1 |
0.805 | 0.005 | -3 | 0.747 |
GRK6 |
0.805 | 0.005 | 1 | 0.852 |
GRK5 |
0.805 | -0.088 | -3 | 0.805 |
DAPK2 |
0.805 | 0.020 | -3 | 0.785 |
ICK |
0.805 | 0.021 | -3 | 0.762 |
NIM1 |
0.805 | 0.038 | 3 | 0.737 |
NDR2 |
0.805 | -0.059 | -3 | 0.729 |
MLK3 |
0.804 | 0.054 | 2 | 0.744 |
NDR1 |
0.803 | -0.046 | -3 | 0.729 |
PIM1 |
0.803 | 0.021 | -3 | 0.687 |
RIPK3 |
0.803 | -0.072 | 3 | 0.699 |
CDK8 |
0.803 | 0.054 | 1 | 0.701 |
CLK4 |
0.802 | 0.078 | -3 | 0.680 |
SRPK2 |
0.802 | 0.039 | -3 | 0.604 |
GRK1 |
0.802 | 0.014 | -2 | 0.712 |
MARK4 |
0.802 | -0.013 | 4 | 0.792 |
HUNK |
0.802 | -0.063 | 2 | 0.781 |
PKACG |
0.802 | 0.024 | -2 | 0.756 |
ALK4 |
0.802 | 0.094 | -2 | 0.829 |
MNK2 |
0.802 | 0.040 | -2 | 0.801 |
SKMLCK |
0.801 | 0.001 | -2 | 0.820 |
PLK1 |
0.801 | 0.045 | -2 | 0.790 |
CLK1 |
0.801 | 0.078 | -3 | 0.653 |
NEK9 |
0.801 | -0.076 | 2 | 0.823 |
MAPKAPK3 |
0.801 | -0.018 | -3 | 0.672 |
AURC |
0.801 | 0.060 | -2 | 0.708 |
CDK5 |
0.801 | 0.099 | 1 | 0.725 |
AMPKA2 |
0.801 | 0.001 | -3 | 0.708 |
DYRK2 |
0.800 | 0.069 | 1 | 0.752 |
CDK1 |
0.800 | 0.099 | 1 | 0.672 |
SRPK3 |
0.800 | 0.035 | -3 | 0.661 |
MLK4 |
0.800 | 0.066 | 2 | 0.741 |
P70S6KB |
0.800 | -0.015 | -3 | 0.702 |
PKCH |
0.800 | 0.043 | 2 | 0.748 |
PKCA |
0.800 | 0.049 | 2 | 0.738 |
PRKD3 |
0.800 | 0.049 | -3 | 0.653 |
ACVR2A |
0.800 | 0.094 | -2 | 0.795 |
PKCG |
0.800 | 0.029 | 2 | 0.739 |
FAM20C |
0.800 | 0.025 | 2 | 0.524 |
PKCB |
0.799 | 0.027 | 2 | 0.742 |
IKKA |
0.799 | -0.007 | -2 | 0.679 |
WNK3 |
0.799 | -0.143 | 1 | 0.829 |
CAMK2D |
0.798 | -0.053 | -3 | 0.747 |
LATS2 |
0.798 | -0.045 | -5 | 0.738 |
NUAK1 |
0.798 | 0.010 | -3 | 0.681 |
CAMK4 |
0.797 | -0.018 | -3 | 0.707 |
CDK2 |
0.797 | 0.083 | 1 | 0.748 |
TGFBR1 |
0.797 | 0.074 | -2 | 0.803 |
PAK1 |
0.797 | 0.015 | -2 | 0.777 |
MAPKAPK2 |
0.797 | 0.007 | -3 | 0.627 |
CDK13 |
0.797 | 0.056 | 1 | 0.689 |
PKR |
0.797 | 0.019 | 1 | 0.862 |
MSK2 |
0.797 | 0.002 | -3 | 0.664 |
DNAPK |
0.796 | 0.078 | 1 | 0.792 |
DLK |
0.796 | -0.111 | 1 | 0.841 |
ANKRD3 |
0.796 | -0.078 | 1 | 0.869 |
GRK7 |
0.796 | 0.063 | 1 | 0.783 |
CDK19 |
0.796 | 0.049 | 1 | 0.661 |
RSK4 |
0.796 | 0.032 | -3 | 0.641 |
MNK1 |
0.795 | 0.025 | -2 | 0.810 |
TTBK2 |
0.795 | -0.117 | 2 | 0.704 |
BCKDK |
0.795 | -0.147 | -1 | 0.814 |
PAK3 |
0.795 | -0.012 | -2 | 0.780 |
JNK3 |
0.795 | 0.083 | 1 | 0.701 |
MELK |
0.795 | -0.003 | -3 | 0.696 |
MLK2 |
0.795 | -0.095 | 2 | 0.816 |
MEK1 |
0.795 | -0.021 | 2 | 0.823 |
ACVR2B |
0.795 | 0.074 | -2 | 0.794 |
NEK2 |
0.794 | -0.037 | 2 | 0.802 |
JNK2 |
0.794 | 0.088 | 1 | 0.663 |
PINK1 |
0.794 | 0.055 | 1 | 0.835 |
TLK2 |
0.794 | 0.066 | 1 | 0.823 |
AURB |
0.794 | 0.055 | -2 | 0.702 |
CLK2 |
0.794 | 0.094 | -3 | 0.664 |
MASTL |
0.794 | -0.211 | -2 | 0.755 |
PAK6 |
0.794 | 0.036 | -2 | 0.742 |
GRK4 |
0.794 | -0.075 | -2 | 0.744 |
AKT2 |
0.793 | 0.046 | -3 | 0.600 |
CDK3 |
0.793 | 0.117 | 1 | 0.611 |
CAMK2B |
0.793 | 0.008 | 2 | 0.705 |
ALK2 |
0.793 | 0.089 | -2 | 0.803 |
PKCZ |
0.793 | -0.004 | 2 | 0.782 |
AURA |
0.793 | 0.067 | -2 | 0.675 |
CDK18 |
0.793 | 0.070 | 1 | 0.642 |
RIPK1 |
0.793 | -0.138 | 1 | 0.839 |
CHAK1 |
0.792 | -0.036 | 2 | 0.766 |
PRP4 |
0.792 | 0.084 | -3 | 0.772 |
QIK |
0.792 | -0.037 | -3 | 0.731 |
SGK3 |
0.792 | 0.048 | -3 | 0.659 |
PKACB |
0.792 | 0.056 | -2 | 0.715 |
BMPR1A |
0.792 | 0.133 | 1 | 0.785 |
SMG1 |
0.791 | 0.008 | 1 | 0.849 |
P38A |
0.791 | 0.066 | 1 | 0.730 |
LATS1 |
0.791 | 0.004 | -3 | 0.751 |
PHKG1 |
0.791 | -0.040 | -3 | 0.718 |
PERK |
0.791 | -0.005 | -2 | 0.817 |
CDK12 |
0.790 | 0.056 | 1 | 0.666 |
HIPK1 |
0.790 | 0.065 | 1 | 0.762 |
PKG2 |
0.790 | 0.040 | -2 | 0.721 |
PKCT |
0.790 | 0.043 | 2 | 0.756 |
VRK2 |
0.790 | -0.072 | 1 | 0.891 |
CDK7 |
0.790 | 0.005 | 1 | 0.712 |
BRAF |
0.790 | 0.024 | -4 | 0.620 |
ERK1 |
0.789 | 0.068 | 1 | 0.658 |
PAK2 |
0.789 | -0.000 | -2 | 0.766 |
CAMK2A |
0.789 | -0.012 | 2 | 0.718 |
ERK2 |
0.789 | 0.059 | 1 | 0.708 |
PLK3 |
0.789 | -0.017 | 2 | 0.724 |
SIK |
0.788 | -0.007 | -3 | 0.652 |
CHK1 |
0.788 | 0.029 | -3 | 0.706 |
MSK1 |
0.788 | 0.021 | -3 | 0.662 |
P38B |
0.788 | 0.071 | 1 | 0.670 |
MEKK2 |
0.788 | 0.065 | 2 | 0.819 |
CDK17 |
0.788 | 0.064 | 1 | 0.595 |
QSK |
0.788 | -0.016 | 4 | 0.774 |
HRI |
0.788 | -0.049 | -2 | 0.819 |
HIPK2 |
0.787 | 0.063 | 1 | 0.664 |
PRKX |
0.787 | 0.058 | -3 | 0.558 |
AKT1 |
0.787 | 0.064 | -3 | 0.606 |
YSK4 |
0.787 | -0.084 | 1 | 0.777 |
P38G |
0.787 | 0.072 | 1 | 0.588 |
PLK4 |
0.787 | -0.019 | 2 | 0.677 |
MYLK4 |
0.786 | -0.005 | -2 | 0.776 |
HIPK3 |
0.786 | 0.050 | 1 | 0.758 |
CDK14 |
0.786 | 0.077 | 1 | 0.683 |
ZAK |
0.785 | -0.016 | 1 | 0.800 |
DYRK1A |
0.785 | 0.042 | 1 | 0.785 |
CDK16 |
0.785 | 0.092 | 1 | 0.611 |
DYRK3 |
0.785 | 0.074 | 1 | 0.771 |
TLK1 |
0.785 | 0.005 | -2 | 0.776 |
CDK9 |
0.784 | 0.017 | 1 | 0.696 |
CAMK1G |
0.784 | -0.018 | -3 | 0.668 |
DCAMKL1 |
0.784 | 0.006 | -3 | 0.672 |
MEK5 |
0.783 | -0.086 | 2 | 0.820 |
MEKK3 |
0.783 | -0.054 | 1 | 0.807 |
GSK3A |
0.783 | 0.063 | 4 | 0.465 |
PKCI |
0.783 | 0.024 | 2 | 0.752 |
SSTK |
0.783 | 0.014 | 4 | 0.759 |
DRAK1 |
0.783 | -0.053 | 1 | 0.771 |
PHKG2 |
0.782 | -0.018 | -3 | 0.691 |
P38D |
0.782 | 0.087 | 1 | 0.614 |
PKCE |
0.782 | 0.061 | 2 | 0.729 |
CK1E |
0.782 | -0.017 | -3 | 0.541 |
IRAK4 |
0.782 | -0.040 | 1 | 0.820 |
BRSK1 |
0.782 | -0.072 | -3 | 0.686 |
MARK2 |
0.782 | -0.022 | 4 | 0.685 |
DCAMKL2 |
0.781 | -0.010 | -3 | 0.702 |
CK1G1 |
0.781 | -0.008 | -3 | 0.550 |
GSK3B |
0.781 | 0.026 | 4 | 0.457 |
WNK4 |
0.781 | -0.059 | -2 | 0.801 |
SNRK |
0.781 | -0.122 | 2 | 0.726 |
MST3 |
0.781 | 0.015 | 2 | 0.789 |
PIM2 |
0.781 | -0.016 | -3 | 0.654 |
MARK3 |
0.781 | -0.034 | 4 | 0.731 |
PKACA |
0.781 | 0.050 | -2 | 0.683 |
GRK2 |
0.780 | -0.048 | -2 | 0.644 |
MEKK1 |
0.780 | -0.079 | 1 | 0.825 |
SMMLCK |
0.780 | 0.000 | -3 | 0.733 |
MAPKAPK5 |
0.780 | -0.082 | -3 | 0.640 |
TAO3 |
0.780 | 0.028 | 1 | 0.806 |
BRSK2 |
0.780 | -0.105 | -3 | 0.708 |
NEK5 |
0.779 | -0.033 | 1 | 0.837 |
EEF2K |
0.779 | 0.065 | 3 | 0.853 |
NEK8 |
0.779 | -0.002 | 2 | 0.815 |
BUB1 |
0.778 | 0.159 | -5 | 0.843 |
PKN1 |
0.778 | 0.031 | -3 | 0.631 |
CDK10 |
0.778 | 0.057 | 1 | 0.671 |
DYRK1B |
0.777 | 0.037 | 1 | 0.695 |
MARK1 |
0.776 | -0.057 | 4 | 0.749 |
CK1A2 |
0.776 | -0.005 | -3 | 0.491 |
CAMKK1 |
0.776 | -0.048 | -2 | 0.730 |
CK1D |
0.776 | -0.015 | -3 | 0.494 |
DYRK4 |
0.775 | 0.040 | 1 | 0.676 |
JNK1 |
0.775 | 0.076 | 1 | 0.651 |
CAMK1D |
0.774 | 0.007 | -3 | 0.578 |
TNIK |
0.774 | 0.080 | 3 | 0.873 |
P70S6K |
0.773 | -0.039 | -3 | 0.617 |
ERK7 |
0.773 | 0.017 | 2 | 0.528 |
AKT3 |
0.773 | 0.044 | -3 | 0.541 |
TAO2 |
0.773 | -0.026 | 2 | 0.826 |
CDK6 |
0.772 | 0.071 | 1 | 0.662 |
TTBK1 |
0.772 | -0.122 | 2 | 0.625 |
HGK |
0.772 | 0.035 | 3 | 0.858 |
SGK1 |
0.771 | 0.043 | -3 | 0.524 |
CDK4 |
0.770 | 0.060 | 1 | 0.655 |
PDK1 |
0.770 | -0.034 | 1 | 0.829 |
MINK |
0.770 | 0.019 | 1 | 0.792 |
CHK2 |
0.770 | 0.022 | -3 | 0.545 |
MST2 |
0.769 | 0.007 | 1 | 0.808 |
DAPK3 |
0.769 | 0.032 | -3 | 0.699 |
PAK5 |
0.769 | -0.003 | -2 | 0.663 |
CAMKK2 |
0.769 | -0.085 | -2 | 0.736 |
IRAK1 |
0.769 | -0.160 | -1 | 0.741 |
CK2A2 |
0.769 | 0.031 | 1 | 0.716 |
PLK2 |
0.769 | 0.037 | -3 | 0.771 |
NEK4 |
0.769 | -0.053 | 1 | 0.802 |
GRK3 |
0.769 | -0.039 | -2 | 0.595 |
PASK |
0.768 | -0.030 | -3 | 0.758 |
NEK11 |
0.768 | -0.125 | 1 | 0.809 |
MPSK1 |
0.768 | -0.047 | 1 | 0.759 |
LKB1 |
0.767 | -0.077 | -3 | 0.762 |
GAK |
0.767 | -0.014 | 1 | 0.806 |
MAK |
0.766 | 0.056 | -2 | 0.699 |
MAP3K15 |
0.766 | -0.036 | 1 | 0.782 |
MEKK6 |
0.766 | -0.034 | 1 | 0.787 |
CAMK1A |
0.765 | 0.021 | -3 | 0.558 |
PAK4 |
0.765 | -0.004 | -2 | 0.674 |
DAPK1 |
0.765 | 0.031 | -3 | 0.688 |
NEK1 |
0.765 | -0.017 | 1 | 0.813 |
MOK |
0.765 | 0.042 | 1 | 0.765 |
GCK |
0.765 | -0.031 | 1 | 0.791 |
LRRK2 |
0.764 | -0.076 | 2 | 0.821 |
TAK1 |
0.764 | -0.030 | 1 | 0.828 |
MRCKB |
0.762 | 0.012 | -3 | 0.634 |
LOK |
0.761 | -0.052 | -2 | 0.760 |
VRK1 |
0.760 | -0.066 | 2 | 0.837 |
STK33 |
0.760 | -0.100 | 2 | 0.619 |
MRCKA |
0.760 | 0.007 | -3 | 0.647 |
KHS2 |
0.760 | 0.029 | 1 | 0.795 |
SBK |
0.760 | 0.009 | -3 | 0.487 |
YSK1 |
0.760 | -0.010 | 2 | 0.791 |
ROCK2 |
0.760 | 0.018 | -3 | 0.678 |
TTK |
0.760 | 0.084 | -2 | 0.792 |
HPK1 |
0.760 | -0.046 | 1 | 0.785 |
MEK2 |
0.759 | -0.091 | 2 | 0.816 |
CK2A1 |
0.759 | 0.018 | 1 | 0.693 |
KHS1 |
0.759 | -0.007 | 1 | 0.787 |
MST1 |
0.758 | -0.043 | 1 | 0.794 |
OSR1 |
0.756 | 0.044 | 2 | 0.794 |
MYO3B |
0.755 | 0.061 | 2 | 0.811 |
RIPK2 |
0.755 | -0.160 | 1 | 0.765 |
DMPK1 |
0.754 | 0.032 | -3 | 0.657 |
NEK3 |
0.753 | -0.089 | 1 | 0.773 |
PDHK3_TYR |
0.753 | 0.033 | 4 | 0.852 |
SLK |
0.753 | -0.083 | -2 | 0.689 |
HASPIN |
0.752 | 0.019 | -1 | 0.689 |
MYO3A |
0.751 | 0.048 | 1 | 0.805 |
PKG1 |
0.751 | 0.002 | -2 | 0.668 |
ROCK1 |
0.751 | 0.022 | -3 | 0.647 |
PBK |
0.748 | -0.071 | 1 | 0.714 |
TESK1_TYR |
0.746 | -0.077 | 3 | 0.857 |
PINK1_TYR |
0.746 | 0.041 | 1 | 0.853 |
ALPHAK3 |
0.746 | 0.020 | -1 | 0.760 |
MAP2K4_TYR |
0.746 | -0.029 | -1 | 0.872 |
YANK3 |
0.745 | -0.034 | 2 | 0.381 |
ASK1 |
0.745 | -0.049 | 1 | 0.775 |
PKMYT1_TYR |
0.744 | -0.040 | 3 | 0.819 |
TAO1 |
0.744 | -0.035 | 1 | 0.743 |
CRIK |
0.743 | -0.012 | -3 | 0.607 |
PDHK4_TYR |
0.743 | -0.037 | 2 | 0.825 |
MAP2K6_TYR |
0.743 | -0.032 | -1 | 0.866 |
MAP2K7_TYR |
0.742 | -0.135 | 2 | 0.827 |
LIMK2_TYR |
0.742 | -0.027 | -3 | 0.808 |
CK1A |
0.742 | -0.037 | -3 | 0.415 |
BMPR2_TYR |
0.740 | -0.040 | -1 | 0.835 |
PDHK1_TYR |
0.739 | -0.069 | -1 | 0.856 |
BIKE |
0.738 | -0.030 | 1 | 0.665 |
LIMK1_TYR |
0.737 | -0.093 | 2 | 0.838 |
TYK2 |
0.736 | -0.018 | 1 | 0.820 |
EPHA6 |
0.734 | -0.030 | -1 | 0.803 |
ROS1 |
0.733 | -0.012 | 3 | 0.733 |
RET |
0.732 | -0.092 | 1 | 0.826 |
JAK2 |
0.732 | -0.032 | 1 | 0.818 |
TYRO3 |
0.732 | -0.049 | 3 | 0.756 |
TNNI3K_TYR |
0.730 | 0.016 | 1 | 0.833 |
STLK3 |
0.730 | -0.093 | 1 | 0.767 |
CK1G3 |
0.730 | -0.009 | -3 | 0.369 |
MST1R |
0.730 | -0.111 | 3 | 0.766 |
EPHB4 |
0.730 | -0.055 | -1 | 0.795 |
CSF1R |
0.729 | -0.029 | 3 | 0.727 |
ABL2 |
0.728 | 0.017 | -1 | 0.765 |
FER |
0.727 | -0.016 | 1 | 0.866 |
JAK3 |
0.727 | -0.059 | 1 | 0.807 |
TXK |
0.725 | 0.021 | 1 | 0.816 |
WEE1_TYR |
0.724 | -0.004 | -1 | 0.731 |
INSRR |
0.724 | -0.059 | 3 | 0.698 |
FLT3 |
0.724 | -0.021 | 3 | 0.745 |
DDR1 |
0.723 | -0.168 | 4 | 0.757 |
AAK1 |
0.723 | 0.006 | 1 | 0.553 |
ABL1 |
0.723 | -0.019 | -1 | 0.757 |
JAK1 |
0.722 | -0.031 | 1 | 0.764 |
EPHA4 |
0.721 | -0.059 | 2 | 0.704 |
PDGFRB |
0.721 | -0.115 | 3 | 0.749 |
NEK10_TYR |
0.721 | -0.090 | 1 | 0.693 |
YES1 |
0.721 | -0.050 | -1 | 0.769 |
FGR |
0.720 | -0.089 | 1 | 0.817 |
TNK1 |
0.720 | -0.071 | 3 | 0.734 |
HCK |
0.720 | -0.047 | -1 | 0.751 |
EPHB1 |
0.720 | -0.069 | 1 | 0.851 |
LCK |
0.719 | -0.007 | -1 | 0.743 |
KIT |
0.719 | -0.075 | 3 | 0.728 |
ITK |
0.719 | -0.059 | -1 | 0.744 |
FGFR2 |
0.718 | -0.115 | 3 | 0.736 |
KDR |
0.718 | -0.070 | 3 | 0.685 |
TEC |
0.718 | -0.017 | -1 | 0.699 |
EPHB3 |
0.718 | -0.062 | -1 | 0.774 |
BLK |
0.717 | 0.006 | -1 | 0.759 |
EPHB2 |
0.717 | -0.060 | -1 | 0.768 |
SRMS |
0.717 | -0.096 | 1 | 0.850 |
TNK2 |
0.716 | -0.131 | 3 | 0.704 |
PDGFRA |
0.716 | -0.133 | 3 | 0.747 |
FRK |
0.716 | 0.016 | -1 | 0.772 |
TEK |
0.715 | -0.127 | 3 | 0.685 |
YANK2 |
0.715 | -0.049 | 2 | 0.404 |
BMX |
0.714 | -0.041 | -1 | 0.666 |
FGFR1 |
0.714 | -0.126 | 3 | 0.702 |
MERTK |
0.714 | -0.061 | 3 | 0.707 |
BTK |
0.714 | -0.090 | -1 | 0.705 |
ALK |
0.713 | -0.079 | 3 | 0.661 |
PTK6 |
0.713 | -0.081 | -1 | 0.683 |
AXL |
0.713 | -0.125 | 3 | 0.708 |
FLT1 |
0.712 | -0.092 | -1 | 0.780 |
LTK |
0.712 | -0.082 | 3 | 0.682 |
MET |
0.710 | -0.098 | 3 | 0.725 |
ERBB2 |
0.709 | -0.114 | 1 | 0.774 |
NTRK1 |
0.709 | -0.134 | -1 | 0.784 |
EPHA7 |
0.709 | -0.092 | 2 | 0.726 |
FLT4 |
0.709 | -0.117 | 3 | 0.691 |
FYN |
0.708 | -0.022 | -1 | 0.716 |
EPHA1 |
0.707 | -0.103 | 3 | 0.702 |
FGFR3 |
0.706 | -0.113 | 3 | 0.708 |
EPHA3 |
0.706 | -0.137 | 2 | 0.698 |
INSR |
0.706 | -0.109 | 3 | 0.694 |
LYN |
0.705 | -0.068 | 3 | 0.661 |
MATK |
0.705 | -0.066 | -1 | 0.699 |
NTRK2 |
0.705 | -0.144 | 3 | 0.685 |
CSK |
0.703 | -0.068 | 2 | 0.736 |
CK1G2 |
0.703 | -0.029 | -3 | 0.461 |
NTRK3 |
0.703 | -0.093 | -1 | 0.735 |
EPHA5 |
0.703 | -0.067 | 2 | 0.701 |
EGFR |
0.702 | -0.061 | 1 | 0.687 |
EPHA8 |
0.701 | -0.061 | -1 | 0.745 |
PTK2B |
0.700 | -0.101 | -1 | 0.731 |
DDR2 |
0.700 | -0.116 | 3 | 0.681 |
SYK |
0.699 | -0.020 | -1 | 0.707 |
FGFR4 |
0.699 | -0.063 | -1 | 0.729 |
MUSK |
0.698 | -0.087 | 1 | 0.665 |
SRC |
0.695 | -0.090 | -1 | 0.722 |
PTK2 |
0.694 | -0.055 | -1 | 0.704 |
IGF1R |
0.694 | -0.067 | 3 | 0.627 |
EPHA2 |
0.688 | -0.101 | -1 | 0.709 |
ERBB4 |
0.684 | -0.078 | 1 | 0.699 |
ZAP70 |
0.676 | -0.039 | -1 | 0.651 |
FES |
0.676 | -0.121 | -1 | 0.646 |