Motif 963 (n=85)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00160 | MYO1F | S923 | ochoa | Unconventional myosin-If (Myosin-Ie) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}. |
| O00425 | IGF2BP3 | S243 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O14654 | IRS4 | S826 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15037 | KHNYN | S459 | ochoa | Protein KHNYN (KH and NYN domain-containing protein) | None |
| O15198 | SMAD9 | S323 | ochoa | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). |
| O43524 | FOXO3 | S232 | psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O43524 | FOXO3 | S644 | psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O60318 | MCM3AP | S579 | ochoa | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}. |
| O96017 | CHEK2 | S210 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P00338 | LDHA | S167 | ochoa | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P00441 | SOD1 | S26 | ochoa | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P00492 | HPRT1 | S110 | ochoa | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| P02730 | SLC4A1 | S356 | ochoa | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P06733 | ENO1 | T379 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07195 | LDHB | S168 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07864 | LDHC | S167 | ochoa | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | Possible role in sperm motility. |
| P09104 | ENO2 | T379 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
| P13164 | IFITM1 | T81 | ochoa | Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:33270927}. |
| P13861 | PRKAR2A | S205 | ochoa | cAMP-dependent protein kinase type II-alpha regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| P13929 | ENO3 | T379 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P17097 | ZNF7 | S128 | ochoa | Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) | May be involved in transcriptional regulation. |
| P17844 | DDX5 | S30 | ochoa | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P21333 | FLNA | S440 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S1367 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P25054 | APC | S2724 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27708 | CAD | S1267 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P30086 | PEBP1 | S98 | ochoa | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P31323 | PRKAR2B | S220 | ochoa | cAMP-dependent protein kinase type II-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| P35222 | CTNNB1 | S311 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35367 | HRH1 | S317 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P35590 | TIE1 | S1028 | ochoa | Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) | Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. {ECO:0000269|PubMed:20227369}. |
| P41229 | KDM5C | S1356 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P46020 | PHKA1 | S981 | ochoa | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
| P46821 | MAP1B | S343 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49327 | FASN | S1028 | psp | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P52597 | HNRNPF | S32 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P53004 | BLVRA | S33 | psp | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
| P62913 | RPL11 | S140 | ochoa | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}. |
| P68104 | EEF1A1 | S21 | ochoa|psp | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P98175 | RBM10 | S905 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q01628 | IFITM3 | T102 | ochoa | Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Interferon-inducible protein 1-8U) | IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927). {ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:23601107, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927}. |
| Q01629 | IFITM2 | T101 | ochoa | Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:26354436, PubMed:33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927, PubMed:33563656). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927, ECO:0000269|PubMed:33563656}. |
| Q02241 | KIF23 | S298 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02388 | COL7A1 | S828 | ochoa | Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Q03188 | CENPC | S673 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04656 | ATP7A | S325 | ochoa | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q05639 | EEF1A2 | S21 | ochoa|psp | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q06187 | BTK | S554 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08881 | ITK | S515 | ochoa | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q09666 | AHNAK | S5552 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12931 | TRAP1 | S194 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q14966 | ZNF638 | S283 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15797 | SMAD1 | S321 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16851 | UGP2 | S103 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Q53EL6 | PDCD4 | S323 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5JSH3 | WDR44 | S871 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5T8D3 | ACBD5 | S262 | ochoa | Acyl-CoA-binding domain-containing protein 5 | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}. |
| Q5VTE0 | EEF1A1P5 | S21 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q6ZMR3 | LDHAL6A | S167 | ochoa | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed. {ECO:0000269|PubMed:18351441}. |
| Q8WWI1 | LMO7 | S1516 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q96H22 | CENPN | S235 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96KR1 | ZFR | S481 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q99717 | SMAD5 | S321 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q9BXT4 | TDRD1 | S678 | ochoa | Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) | Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). {ECO:0000250}. |
| Q9BYI3 | HYCC1 | S482 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9BZE9 | ASPSCR1 | S165 | ochoa | Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9) | Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269|PubMed:23349634}. |
| Q9NW68 | BSDC1 | S374 | ochoa | BSD domain-containing protein 1 | None |
| Q9UQP3 | TNN | S937 | ochoa | Tenascin-N (TN-N) (Tenascin-W) (TN-W) | Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). {ECO:0000250|UniProtKB:Q80YX1, ECO:0000250|UniProtKB:Q80Z71, ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}. |
| Q9Y2H6 | FNDC3A | S234 | ochoa | Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) | Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}. |
| P62241 | RPS8 | S66 | Sugiyama | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q7RTV0 | PHF5A | S53 | Sugiyama | PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28541300, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, PHF5A is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Also involved in elongation by RNA polymerase II as part of the PAF1 complex (PAF1C) (By similarity). PAF1C is required for maintenance of embryonic stem cell (ESC) self-renewal and cellular reprogramming of stem cells (By similarity). Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes (By similarity). Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes (By similarity). Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies (By similarity). Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity). {ECO:0000250|UniProtKB:P83870, ECO:0000250|UniProtKB:P83871, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| P04818 | TYMS | S120 | Sugiyama | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}. |
| O95302 | FKBP9 | S275 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase) | PPIases accelerate the folding of proteins during protein synthesis. |
| P30050 | RPL12 | S26 | Sugiyama | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P07332 | FES | S716 | Sugiyama | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| Q9NZV7 | ZIM2 | S155 | Sugiyama | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| P62873 | GNB1 | S207 | Sugiyama | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:37991948, PubMed:38168118, PubMed:38552625). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). {ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:35835867, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:38168118, ECO:0000269|PubMed:38552625}. |
| Q04726 | TLE3 | S622 | Sugiyama | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q9UQ80 | PA2G4 | S40 | Sugiyama | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q12778 | FOXO1 | S235 | PSP | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q16401 | PSMD5 | S98 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5. {ECO:0000269|PubMed:19412159, ECO:0000269|PubMed:19490896}. |
| P18827 | SDC1 | S243 | Sugiyama | Syndecan-1 (SYND1) (CD antigen CD138) | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18828, ECO:0000269|PubMed:22660413}. |
| P62191 | PSMC1 | S244 | Sugiyama | 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P62879 | GNB2 | S207 | Sugiyama | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Q14697 | GANAB | S924 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.000009 | 5.070 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.000019 | 4.728 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.000055 | 4.263 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.000039 | 4.407 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.000062 | 4.207 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.000138 | 3.859 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.000195 | 3.711 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.000266 | 3.575 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.000274 | 3.563 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.000322 | 3.493 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.000400 | 3.398 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.000400 | 3.398 |
| R-HSA-9634597 | GPER1 signaling | 0.000492 | 3.308 |
| R-HSA-163685 | Integration of energy metabolism | 0.000479 | 3.320 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.000911 | 3.041 |
| R-HSA-449147 | Signaling by Interleukins | 0.000894 | 3.049 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.001064 | 2.973 |
| R-HSA-201451 | Signaling by BMP | 0.001306 | 2.884 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.001361 | 2.866 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.001662 | 2.779 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.002097 | 2.678 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.002775 | 2.557 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.002943 | 2.531 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.003746 | 2.426 |
| R-HSA-156902 | Peptide chain elongation | 0.003626 | 2.441 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.003746 | 2.426 |
| R-HSA-70268 | Pyruvate metabolism | 0.003496 | 2.456 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.004282 | 2.368 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.004852 | 2.314 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.004852 | 2.314 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.004852 | 2.314 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.004852 | 2.314 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.004852 | 2.314 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.004852 | 2.314 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.005454 | 2.263 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.005454 | 2.263 |
| R-HSA-422356 | Regulation of insulin secretion | 0.005456 | 2.263 |
| R-HSA-75153 | Apoptotic execution phase | 0.005196 | 2.284 |
| R-HSA-70263 | Gluconeogenesis | 0.005742 | 2.241 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.006376 | 2.195 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.006757 | 2.170 |
| R-HSA-111885 | Opioid Signalling | 0.006567 | 2.183 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.007329 | 2.135 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.008186 | 2.087 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.008262 | 2.083 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.009739 | 2.011 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.009739 | 2.011 |
| R-HSA-163615 | PKA activation | 0.009739 | 2.011 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.009739 | 2.011 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.009739 | 2.011 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.010560 | 1.976 |
| R-HSA-202040 | G-protein activation | 0.012292 | 1.910 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.012292 | 1.910 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.012292 | 1.910 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.011753 | 1.930 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.013201 | 1.879 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.017118 | 1.767 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.017118 | 1.767 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.017118 | 1.767 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.017884 | 1.748 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.016097 | 1.793 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.018165 | 1.741 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.015104 | 1.821 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.018133 | 1.742 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.016097 | 1.793 |
| R-HSA-195721 | Signaling by WNT | 0.016714 | 1.777 |
| R-HSA-4086398 | Ca2+ pathway | 0.015499 | 1.810 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.017142 | 1.766 |
| R-HSA-3214842 | HDMs demethylate histones | 0.017118 | 1.767 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.014330 | 1.844 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.015104 | 1.821 |
| R-HSA-168256 | Immune System | 0.015584 | 1.807 |
| R-HSA-913531 | Interferon Signaling | 0.015338 | 1.814 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.019008 | 1.721 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.019008 | 1.721 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.019239 | 1.716 |
| R-HSA-9734281 | Defective HPRT1 disrupts guanine and hypoxanthine salvage | 0.031480 | 1.502 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.026754 | 1.573 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.027440 | 1.562 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.030278 | 1.519 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.031011 | 1.508 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.031011 | 1.508 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.028737 | 1.542 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.028737 | 1.542 |
| R-HSA-392518 | Signal amplification | 0.028737 | 1.542 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.031011 | 1.508 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.027465 | 1.561 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.024991 | 1.602 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.024991 | 1.602 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.024103 | 1.618 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.022615 | 1.646 |
| R-HSA-72766 | Translation | 0.025802 | 1.588 |
| R-HSA-390650 | Histamine receptors | 0.031480 | 1.502 |
| R-HSA-391251 | Protein folding | 0.028136 | 1.551 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.022213 | 1.653 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.032505 | 1.488 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.020338 | 1.692 |
| R-HSA-180024 | DARPP-32 events | 0.021464 | 1.668 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.024088 | 1.618 |
| R-HSA-9733709 | Cardiogenesis | 0.026216 | 1.581 |
| R-HSA-111933 | Calmodulin induced events | 0.031351 | 1.504 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.021464 | 1.668 |
| R-HSA-111997 | CaM pathway | 0.031351 | 1.504 |
| R-HSA-8939211 | ESR-mediated signaling | 0.025071 | 1.601 |
| R-HSA-109581 | Apoptosis | 0.028867 | 1.540 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.024991 | 1.602 |
| R-HSA-5663205 | Infectious disease | 0.023636 | 1.626 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.031351 | 1.504 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.037658 | 1.424 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.037658 | 1.424 |
| R-HSA-192823 | Viral mRNA Translation | 0.037208 | 1.429 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.041379 | 1.383 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.039725 | 1.401 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.041242 | 1.385 |
| R-HSA-991365 | Activation of GABAB receptors | 0.041194 | 1.385 |
| R-HSA-418555 | G alpha (s) signalling events | 0.034172 | 1.466 |
| R-HSA-977444 | GABA B receptor activation | 0.041194 | 1.385 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.035603 | 1.449 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.035441 | 1.450 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.038024 | 1.420 |
| R-HSA-69541 | Stabilization of p53 | 0.035441 | 1.450 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.034815 | 1.458 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.041194 | 1.385 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.035603 | 1.449 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.035297 | 1.452 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.035297 | 1.452 |
| R-HSA-111996 | Ca-dependent events | 0.041194 | 1.385 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.038055 | 1.420 |
| R-HSA-8982491 | Glycogen metabolism | 0.036848 | 1.434 |
| R-HSA-70171 | Glycolysis | 0.034815 | 1.458 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.036443 | 1.438 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.042241 | 1.374 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.042241 | 1.374 |
| R-HSA-162582 | Signal Transduction | 0.043213 | 1.364 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.043796 | 1.359 |
| R-HSA-9907900 | Proteasome assembly | 0.044194 | 1.355 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.044532 | 1.351 |
| R-HSA-9658195 | Leishmania infection | 0.044532 | 1.351 |
| R-HSA-774815 | Nucleosome assembly | 0.045723 | 1.340 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.045723 | 1.340 |
| R-HSA-9824272 | Somitogenesis | 0.045723 | 1.340 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.045723 | 1.340 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.045723 | 1.340 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.045723 | 1.340 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.045777 | 1.339 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.045777 | 1.339 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.049896 | 1.302 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.061979 | 1.208 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.061979 | 1.208 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.048400 | 1.315 |
| R-HSA-72172 | mRNA Splicing | 0.056204 | 1.250 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.051347 | 1.289 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.051347 | 1.289 |
| R-HSA-9766229 | Degradation of CDH1 | 0.052032 | 1.284 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.049896 | 1.302 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.052032 | 1.284 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.052032 | 1.284 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.052032 | 1.284 |
| R-HSA-5357801 | Programmed Cell Death | 0.056946 | 1.245 |
| R-HSA-70326 | Glucose metabolism | 0.052306 | 1.281 |
| R-HSA-1643685 | Disease | 0.057674 | 1.239 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.056733 | 1.246 |
| R-HSA-69206 | G1/S Transition | 0.061324 | 1.212 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.047051 | 1.327 |
| R-HSA-418597 | G alpha (z) signalling events | 0.062033 | 1.207 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.062282 | 1.206 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.065502 | 1.184 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.067260 | 1.172 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.067260 | 1.172 |
| R-HSA-9734207 | Nucleotide salvage defects | 0.067964 | 1.168 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.067964 | 1.168 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.067964 | 1.168 |
| R-HSA-977443 | GABA receptor activation | 0.070823 | 1.150 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.085692 | 1.067 |
| R-HSA-4839744 | Signaling by APC mutants | 0.085692 | 1.067 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.085692 | 1.067 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.085692 | 1.067 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.085692 | 1.067 |
| R-HSA-2214320 | Anchoring fibril formation | 0.091527 | 1.038 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.097324 | 1.012 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.097324 | 1.012 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.079820 | 1.098 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.079820 | 1.098 |
| R-HSA-4641265 | Repression of WNT target genes | 0.097324 | 1.012 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 0.079820 | 1.098 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.091527 | 1.038 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.091527 | 1.038 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.072628 | 1.139 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.079820 | 1.098 |
| R-HSA-9683686 | Maturation of spike protein | 0.079820 | 1.098 |
| R-HSA-425381 | Bicarbonate transporters | 0.085692 | 1.067 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.091527 | 1.038 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.103086 | 0.987 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.103534 | 0.985 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.103086 | 0.987 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 0.103086 | 0.987 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 0.108811 | 0.963 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.108811 | 0.963 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.097324 | 1.012 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.076281 | 1.118 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.099927 | 1.000 |
| R-HSA-9711097 | Cellular response to starvation | 0.103831 | 0.984 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.085430 | 1.068 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.078129 | 1.107 |
| R-HSA-1640170 | Cell Cycle | 0.095728 | 1.019 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.073911 | 1.131 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.082897 | 1.081 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.077839 | 1.109 |
| R-HSA-8953854 | Metabolism of RNA | 0.097741 | 1.010 |
| R-HSA-112043 | PLC beta mediated events | 0.072628 | 1.139 |
| R-HSA-112040 | G-protein mediated events | 0.083757 | 1.077 |
| R-HSA-8983711 | OAS antiviral response | 0.097324 | 1.012 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.106468 | 0.973 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.103086 | 0.987 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.076281 | 1.118 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.083296 | 1.079 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.082550 | 1.083 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.108811 | 0.963 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.107404 | 0.969 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.103347 | 0.986 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.088589 | 1.053 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.125769 | 0.900 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.125769 | 0.900 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.131350 | 0.882 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.153325 | 0.814 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.158733 | 0.799 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.190465 | 0.720 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.190465 | 0.720 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.195637 | 0.709 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.195637 | 0.709 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.121928 | 0.914 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.121928 | 0.914 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.156700 | 0.805 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.164106 | 0.785 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.142408 | 0.846 |
| R-HSA-525793 | Myogenesis | 0.185260 | 0.732 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.158933 | 0.799 |
| R-HSA-3000170 | Syndecan interactions | 0.169445 | 0.771 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.114499 | 0.941 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.120152 | 0.920 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.120152 | 0.920 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.210958 | 0.676 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.180021 | 0.745 |
| R-HSA-9694614 | Attachment and Entry | 0.158733 | 0.799 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.200009 | 0.699 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.142408 | 0.846 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.121425 | 0.916 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.158733 | 0.799 |
| R-HSA-2024096 | HS-GAG degradation | 0.216001 | 0.666 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.111818 | 0.951 |
| R-HSA-2424491 | DAP12 signaling | 0.205884 | 0.686 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.125675 | 0.901 |
| R-HSA-9834899 | Specification of the neural plate border | 0.142408 | 0.846 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.210958 | 0.676 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.216001 | 0.666 |
| R-HSA-68877 | Mitotic Prometaphase | 0.154958 | 0.810 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.213982 | 0.670 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.200777 | 0.697 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.174750 | 0.758 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.174750 | 0.758 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 0.120152 | 0.920 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.125769 | 0.900 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.190465 | 0.720 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.200777 | 0.697 |
| R-HSA-8876725 | Protein methylation | 0.114499 | 0.941 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.136896 | 0.864 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.159532 | 0.797 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.181571 | 0.741 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.147431 | 0.831 |
| R-HSA-416476 | G alpha (q) signalling events | 0.109662 | 0.960 |
| R-HSA-418990 | Adherens junctions interactions | 0.195869 | 0.708 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.190465 | 0.720 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.125633 | 0.901 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.125633 | 0.901 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.130432 | 0.885 |
| R-HSA-446728 | Cell junction organization | 0.124578 | 0.905 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.120230 | 0.920 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.169445 | 0.771 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.147884 | 0.830 |
| R-HSA-1500931 | Cell-Cell communication | 0.168998 | 0.772 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.158733 | 0.799 |
| R-HSA-1296071 | Potassium Channels | 0.150037 | 0.824 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.142408 | 0.846 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.210958 | 0.676 |
| R-HSA-72312 | rRNA processing | 0.218911 | 0.660 |
| R-HSA-3000157 | Laminin interactions | 0.180021 | 0.745 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.142408 | 0.846 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.180021 | 0.745 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 0.195637 | 0.709 |
| R-HSA-68886 | M Phase | 0.116908 | 0.932 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.179284 | 0.746 |
| R-HSA-449836 | Other interleukin signaling | 0.142408 | 0.846 |
| R-HSA-9833110 | RSV-host interactions | 0.170187 | 0.769 |
| R-HSA-9830364 | Formation of the nephric duct | 0.180021 | 0.745 |
| R-HSA-73886 | Chromosome Maintenance | 0.213982 | 0.670 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.114499 | 0.941 |
| R-HSA-418346 | Platelet homeostasis | 0.174726 | 0.758 |
| R-HSA-68882 | Mitotic Anaphase | 0.192629 | 0.715 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.128467 | 0.891 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.170362 | 0.769 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.194247 | 0.712 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.208798 | 0.680 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.136896 | 0.864 |
| R-HSA-1181150 | Signaling by NODAL | 0.147884 | 0.830 |
| R-HSA-109582 | Hemostasis | 0.144087 | 0.841 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.209313 | 0.679 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.111818 | 0.951 |
| R-HSA-983712 | Ion channel transport | 0.148927 | 0.827 |
| R-HSA-202403 | TCR signaling | 0.183862 | 0.736 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.126163 | 0.899 |
| R-HSA-2262752 | Cellular responses to stress | 0.128287 | 0.892 |
| R-HSA-9824446 | Viral Infection Pathways | 0.116586 | 0.933 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.206982 | 0.684 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.131350 | 0.882 |
| R-HSA-3322077 | Glycogen synthesis | 0.147884 | 0.830 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.211456 | 0.675 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.132580 | 0.878 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.174726 | 0.758 |
| R-HSA-422475 | Axon guidance | 0.155226 | 0.809 |
| R-HSA-9675108 | Nervous system development | 0.189609 | 0.722 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.177737 | 0.750 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.142408 | 0.846 |
| R-HSA-9679506 | SARS-CoV Infections | 0.164227 | 0.785 |
| R-HSA-168255 | Influenza Infection | 0.134205 | 0.872 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.204655 | 0.689 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.163417 | 0.787 |
| R-HSA-382551 | Transport of small molecules | 0.191688 | 0.717 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.213982 | 0.670 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.221012 | 0.656 |
| R-HSA-15869 | Metabolism of nucleotides | 0.225598 | 0.647 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.225991 | 0.646 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.225991 | 0.646 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.225991 | 0.646 |
| R-HSA-189483 | Heme degradation | 0.225991 | 0.646 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.225991 | 0.646 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.228045 | 0.642 |
| R-HSA-69481 | G2/M Checkpoints | 0.230396 | 0.638 |
| R-HSA-114608 | Platelet degranulation | 0.230396 | 0.638 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.230938 | 0.637 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.230938 | 0.637 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.230938 | 0.637 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.230938 | 0.637 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.235854 | 0.627 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.235854 | 0.627 |
| R-HSA-169911 | Regulation of Apoptosis | 0.235854 | 0.627 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.240739 | 0.618 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.240739 | 0.618 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.240739 | 0.618 |
| R-HSA-3371511 | HSF1 activation | 0.240739 | 0.618 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.240739 | 0.618 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.240739 | 0.618 |
| R-HSA-9843745 | Adipogenesis | 0.242174 | 0.616 |
| R-HSA-4641258 | Degradation of DVL | 0.245593 | 0.610 |
| R-HSA-4641257 | Degradation of AXIN | 0.245593 | 0.610 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.245593 | 0.610 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.245593 | 0.610 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.245593 | 0.610 |
| R-HSA-8948216 | Collagen chain trimerization | 0.245593 | 0.610 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.246893 | 0.607 |
| R-HSA-74217 | Purine salvage | 0.250416 | 0.601 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.250416 | 0.601 |
| R-HSA-421270 | Cell-cell junction organization | 0.251009 | 0.600 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.255209 | 0.593 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.255209 | 0.593 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.255209 | 0.593 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.255209 | 0.593 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.256342 | 0.591 |
| R-HSA-5688426 | Deubiquitination | 0.257861 | 0.589 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.258706 | 0.587 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.259972 | 0.585 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.259972 | 0.585 |
| R-HSA-167169 | HIV Transcription Elongation | 0.259972 | 0.585 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.259972 | 0.585 |
| R-HSA-5260271 | Diseases of Immune System | 0.259972 | 0.585 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.259972 | 0.585 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.259972 | 0.585 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.259972 | 0.585 |
| R-HSA-202433 | Generation of second messenger molecules | 0.259972 | 0.585 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.259972 | 0.585 |
| R-HSA-9694548 | Maturation of spike protein | 0.264704 | 0.577 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.264704 | 0.577 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.264704 | 0.577 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.264704 | 0.577 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.264704 | 0.577 |
| R-HSA-9607240 | FLT3 Signaling | 0.264704 | 0.577 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.264704 | 0.577 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.269406 | 0.570 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.269406 | 0.570 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.269406 | 0.570 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.269406 | 0.570 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.269406 | 0.570 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.269406 | 0.570 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.269406 | 0.570 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.278722 | 0.555 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.278722 | 0.555 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.278722 | 0.555 |
| R-HSA-2172127 | DAP12 interactions | 0.283335 | 0.548 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.283335 | 0.548 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.283335 | 0.548 |
| R-HSA-2187338 | Visual phototransduction | 0.284711 | 0.546 |
| R-HSA-392499 | Metabolism of proteins | 0.287331 | 0.542 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.287919 | 0.541 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.287919 | 0.541 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.287919 | 0.541 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.287919 | 0.541 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.287919 | 0.541 |
| R-HSA-9758941 | Gastrulation | 0.289434 | 0.538 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.292475 | 0.534 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.292475 | 0.534 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.292475 | 0.534 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.292475 | 0.534 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.292475 | 0.534 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.292475 | 0.534 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.292475 | 0.534 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.292475 | 0.534 |
| R-HSA-418594 | G alpha (i) signalling events | 0.293418 | 0.533 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.294154 | 0.531 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.297001 | 0.527 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.305968 | 0.514 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.310409 | 0.508 |
| R-HSA-9748787 | Azathioprine ADME | 0.310409 | 0.508 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.310638 | 0.508 |
| R-HSA-2514856 | The phototransduction cascade | 0.314822 | 0.502 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.314822 | 0.502 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.314822 | 0.502 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.314822 | 0.502 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.319206 | 0.496 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.319206 | 0.496 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.319206 | 0.496 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.319206 | 0.496 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.323563 | 0.490 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.323563 | 0.490 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.323563 | 0.490 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.323563 | 0.490 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.323563 | 0.490 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.323563 | 0.490 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.327372 | 0.485 |
| R-HSA-72649 | Translation initiation complex formation | 0.327893 | 0.484 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.327893 | 0.484 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.327893 | 0.484 |
| R-HSA-156588 | Glucuronidation | 0.327893 | 0.484 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.332195 | 0.479 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.336469 | 0.473 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.336469 | 0.473 |
| R-HSA-5578775 | Ion homeostasis | 0.336469 | 0.473 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.344938 | 0.462 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.345674 | 0.461 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.347992 | 0.458 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.349132 | 0.457 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.349132 | 0.457 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.349132 | 0.457 |
| R-HSA-186712 | Regulation of beta-cell development | 0.349132 | 0.457 |
| R-HSA-983189 | Kinesins | 0.353299 | 0.452 |
| R-HSA-351202 | Metabolism of polyamines | 0.353299 | 0.452 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.357440 | 0.447 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.357440 | 0.447 |
| R-HSA-1442490 | Collagen degradation | 0.357440 | 0.447 |
| R-HSA-8956321 | Nucleotide salvage | 0.357440 | 0.447 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.361554 | 0.442 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.361554 | 0.442 |
| R-HSA-1430728 | Metabolism | 0.363258 | 0.440 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.365643 | 0.437 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.365643 | 0.437 |
| R-HSA-373755 | Semaphorin interactions | 0.365643 | 0.437 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.369705 | 0.432 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.373742 | 0.427 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.373742 | 0.427 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.373742 | 0.427 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.377753 | 0.423 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.377753 | 0.423 |
| R-HSA-69275 | G2/M Transition | 0.377859 | 0.423 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.381739 | 0.418 |
| R-HSA-9830369 | Kidney development | 0.381739 | 0.418 |
| R-HSA-112316 | Neuronal System | 0.381802 | 0.418 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.382406 | 0.417 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.385700 | 0.414 |
| R-HSA-167172 | Transcription of the HIV genome | 0.385700 | 0.414 |
| R-HSA-1474244 | Extracellular matrix organization | 0.390071 | 0.409 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.393545 | 0.405 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.393545 | 0.405 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.393545 | 0.405 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.393545 | 0.405 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.393545 | 0.405 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.397431 | 0.401 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.397431 | 0.401 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.397431 | 0.401 |
| R-HSA-3000178 | ECM proteoglycans | 0.397431 | 0.401 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.397431 | 0.401 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.397431 | 0.401 |
| R-HSA-9638482 | Metal ion assimilation from the host | 0.397431 | 0.401 |
| R-HSA-189445 | Metabolism of porphyrins | 0.397431 | 0.401 |
| R-HSA-388396 | GPCR downstream signalling | 0.399310 | 0.399 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.401292 | 0.397 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.401292 | 0.397 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.401292 | 0.397 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.405128 | 0.392 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.405128 | 0.392 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.405128 | 0.392 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.408940 | 0.388 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.408940 | 0.388 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.408940 | 0.388 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.409388 | 0.388 |
| R-HSA-380287 | Centrosome maturation | 0.412728 | 0.384 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.412728 | 0.384 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.412728 | 0.384 |
| R-HSA-5689603 | UCH proteinases | 0.416492 | 0.380 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.416492 | 0.380 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.420232 | 0.377 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.423948 | 0.373 |
| R-HSA-5619084 | ABC transporter disorders | 0.423948 | 0.373 |
| R-HSA-4086400 | PCP/CE pathway | 0.423948 | 0.373 |
| R-HSA-216083 | Integrin cell surface interactions | 0.423948 | 0.373 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.427641 | 0.369 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.431310 | 0.365 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.434956 | 0.362 |
| R-HSA-397014 | Muscle contraction | 0.437968 | 0.359 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.442179 | 0.354 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.442179 | 0.354 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.445755 | 0.351 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.445755 | 0.351 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.445755 | 0.351 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.449310 | 0.347 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.452841 | 0.344 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.456350 | 0.341 |
| R-HSA-8951664 | Neddylation | 0.457318 | 0.340 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.463302 | 0.334 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.463302 | 0.334 |
| R-HSA-162906 | HIV Infection | 0.470007 | 0.328 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.470166 | 0.328 |
| R-HSA-202424 | Downstream TCR signaling | 0.470166 | 0.328 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.479444 | 0.319 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.480298 | 0.318 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.483633 | 0.315 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.483633 | 0.315 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.484589 | 0.315 |
| R-HSA-1474290 | Collagen formation | 0.486946 | 0.313 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.490825 | 0.309 |
| R-HSA-372790 | Signaling by GPCR | 0.493770 | 0.306 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.496761 | 0.304 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.496761 | 0.304 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.496761 | 0.304 |
| R-HSA-157118 | Signaling by NOTCH | 0.496892 | 0.304 |
| R-HSA-190236 | Signaling by FGFR | 0.503201 | 0.298 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.509559 | 0.293 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.511011 | 0.292 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.512708 | 0.290 |
| R-HSA-4839726 | Chromatin organization | 0.514997 | 0.288 |
| R-HSA-1280218 | Adaptive Immune System | 0.528206 | 0.277 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.528784 | 0.277 |
| R-HSA-211000 | Gene Silencing by RNA | 0.534195 | 0.272 |
| R-HSA-69239 | Synthesis of DNA | 0.534195 | 0.272 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.534195 | 0.272 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.534195 | 0.272 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.537187 | 0.270 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.540160 | 0.267 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.541257 | 0.267 |
| R-HSA-6803157 | Antimicrobial peptides | 0.546050 | 0.263 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.563274 | 0.249 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.574395 | 0.241 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.574395 | 0.241 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.577658 | 0.238 |
| R-HSA-3371556 | Cellular response to heat stress | 0.579850 | 0.237 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.579850 | 0.237 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.581342 | 0.236 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.582552 | 0.235 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.582552 | 0.235 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.585236 | 0.233 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.585236 | 0.233 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.587599 | 0.231 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.587903 | 0.231 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.590177 | 0.229 |
| R-HSA-194138 | Signaling by VEGF | 0.593187 | 0.227 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.602422 | 0.220 |
| R-HSA-9717189 | Sensory perception of taste | 0.611156 | 0.214 |
| R-HSA-5576891 | Cardiac conduction | 0.611156 | 0.214 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.613658 | 0.212 |
| R-HSA-9909396 | Circadian clock | 0.613658 | 0.212 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.613658 | 0.212 |
| R-HSA-1266738 | Developmental Biology | 0.615021 | 0.211 |
| R-HSA-6807070 | PTEN Regulation | 0.633109 | 0.199 |
| R-HSA-9664407 | Parasite infection | 0.635471 | 0.197 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.635471 | 0.197 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.635471 | 0.197 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.637819 | 0.195 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.642468 | 0.192 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.647058 | 0.189 |
| R-HSA-8957322 | Metabolism of steroids | 0.648669 | 0.188 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.653834 | 0.185 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.656064 | 0.183 |
| R-HSA-69242 | S Phase | 0.656064 | 0.183 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.660482 | 0.180 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.660482 | 0.180 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.664843 | 0.177 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.664843 | 0.177 |
| R-HSA-9609507 | Protein localization | 0.667002 | 0.176 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.667002 | 0.176 |
| R-HSA-69306 | DNA Replication | 0.667002 | 0.176 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.669148 | 0.174 |
| R-HSA-9612973 | Autophagy | 0.673399 | 0.172 |
| R-HSA-162587 | HIV Life Cycle | 0.675504 | 0.170 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.681739 | 0.166 |
| R-HSA-5619102 | SLC transporter disorders | 0.695830 | 0.157 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.705515 | 0.151 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.707289 | 0.150 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.711179 | 0.148 |
| R-HSA-611105 | Respiratory electron transport | 0.718563 | 0.144 |
| R-HSA-3781865 | Diseases of glycosylation | 0.729290 | 0.137 |
| R-HSA-5617833 | Cilium Assembly | 0.739612 | 0.131 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.741294 | 0.130 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.744626 | 0.128 |
| R-HSA-500792 | GPCR ligand binding | 0.752778 | 0.123 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.755956 | 0.122 |
| R-HSA-597592 | Post-translational protein modification | 0.759033 | 0.120 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.759101 | 0.120 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.760658 | 0.119 |
| R-HSA-8978868 | Fatty acid metabolism | 0.762221 | 0.118 |
| R-HSA-168249 | Innate Immune System | 0.769712 | 0.114 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.777144 | 0.109 |
| R-HSA-5668914 | Diseases of metabolism | 0.784129 | 0.106 |
| R-HSA-9748784 | Drug ADME | 0.784261 | 0.106 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.795183 | 0.100 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.797827 | 0.098 |
| R-HSA-212436 | Generic Transcription Pathway | 0.799100 | 0.097 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.799136 | 0.097 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.800437 | 0.097 |
| R-HSA-199991 | Membrane Trafficking | 0.806113 | 0.094 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.809312 | 0.092 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.811775 | 0.091 |
| R-HSA-6798695 | Neutrophil degranulation | 0.813700 | 0.090 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.820957 | 0.086 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.838985 | 0.076 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.869149 | 0.061 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.888979 | 0.051 |
| R-HSA-74160 | Gene expression (Transcription) | 0.902452 | 0.045 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.904625 | 0.044 |
| R-HSA-73894 | DNA Repair | 0.914543 | 0.039 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.932070 | 0.031 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.933395 | 0.030 |
| R-HSA-211859 | Biological oxidations | 0.970979 | 0.013 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.997079 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.997309 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.997764 | 0.001 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.842 | 0.200 | 2 | 0.816 |
MOS |
0.827 | 0.099 | 1 | 0.835 |
DSTYK |
0.827 | 0.101 | 2 | 0.835 |
NEK6 |
0.825 | 0.126 | -2 | 0.885 |
MLK1 |
0.824 | 0.109 | 2 | 0.849 |
NEK7 |
0.824 | 0.055 | -3 | 0.674 |
ULK2 |
0.823 | 0.040 | 2 | 0.815 |
GCN2 |
0.823 | 0.009 | 2 | 0.805 |
CDC7 |
0.822 | 0.012 | 1 | 0.818 |
ERK5 |
0.822 | 0.150 | 1 | 0.859 |
PRPK |
0.822 | -0.044 | -1 | 0.769 |
SKMLCK |
0.821 | 0.096 | -2 | 0.849 |
TGFBR2 |
0.819 | 0.087 | -2 | 0.831 |
RIPK3 |
0.819 | 0.066 | 3 | 0.844 |
BMPR2 |
0.819 | 0.023 | -2 | 0.872 |
MST4 |
0.818 | 0.123 | 2 | 0.874 |
BMPR1B |
0.818 | 0.176 | 1 | 0.816 |
PKN3 |
0.818 | 0.056 | -3 | 0.653 |
TBK1 |
0.818 | -0.017 | 1 | 0.753 |
ANKRD3 |
0.818 | 0.132 | 1 | 0.861 |
NLK |
0.817 | 0.019 | 1 | 0.807 |
PDHK4 |
0.816 | -0.123 | 1 | 0.846 |
MTOR |
0.816 | -0.046 | 1 | 0.812 |
RAF1 |
0.816 | -0.047 | 1 | 0.834 |
PIM3 |
0.815 | -0.002 | -3 | 0.680 |
CAMK1B |
0.815 | -0.025 | -3 | 0.663 |
CAMK2G |
0.815 | -0.030 | 2 | 0.734 |
IKKB |
0.815 | -0.047 | -2 | 0.727 |
IKKA |
0.815 | 0.078 | -2 | 0.716 |
IKKE |
0.814 | -0.033 | 1 | 0.734 |
PLK1 |
0.814 | 0.104 | -2 | 0.835 |
HUNK |
0.814 | -0.007 | 2 | 0.806 |
PDHK1 |
0.814 | -0.038 | 1 | 0.826 |
MLK4 |
0.814 | 0.117 | 2 | 0.793 |
GRK1 |
0.814 | 0.065 | -2 | 0.734 |
ULK1 |
0.814 | -0.015 | -3 | 0.652 |
PKCD |
0.814 | 0.096 | 2 | 0.825 |
NDR2 |
0.814 | 0.013 | -3 | 0.709 |
GRK6 |
0.814 | 0.021 | 1 | 0.844 |
CDKL1 |
0.813 | -0.002 | -3 | 0.635 |
GRK5 |
0.813 | -0.045 | -3 | 0.724 |
CDKL5 |
0.813 | 0.061 | -3 | 0.620 |
CLK3 |
0.813 | 0.040 | 1 | 0.788 |
GRK4 |
0.812 | -0.002 | -2 | 0.798 |
NEK9 |
0.812 | 0.038 | 2 | 0.852 |
CAMLCK |
0.812 | 0.017 | -2 | 0.846 |
MLK3 |
0.812 | 0.101 | 2 | 0.808 |
NIK |
0.812 | -0.016 | -3 | 0.696 |
PKN2 |
0.811 | 0.039 | -3 | 0.654 |
PLK4 |
0.810 | 0.119 | 2 | 0.694 |
TGFBR1 |
0.810 | 0.113 | -2 | 0.817 |
DAPK2 |
0.810 | 0.009 | -3 | 0.669 |
RSK3 |
0.810 | 0.016 | -3 | 0.587 |
MARK4 |
0.809 | 0.056 | 4 | 0.857 |
P90RSK |
0.809 | -0.002 | -3 | 0.600 |
NUAK2 |
0.809 | 0.004 | -3 | 0.636 |
LATS1 |
0.809 | 0.071 | -3 | 0.695 |
GRK7 |
0.808 | 0.084 | 1 | 0.794 |
RSK2 |
0.808 | 0.009 | -3 | 0.589 |
MASTL |
0.808 | -0.085 | -2 | 0.800 |
ACVR2B |
0.808 | 0.107 | -2 | 0.819 |
ATR |
0.808 | -0.080 | 1 | 0.782 |
ALK4 |
0.807 | 0.070 | -2 | 0.840 |
PKCA |
0.807 | 0.112 | 2 | 0.801 |
FAM20C |
0.807 | 0.071 | 2 | 0.528 |
WNK1 |
0.807 | -0.031 | -2 | 0.842 |
KIS |
0.807 | 0.029 | 1 | 0.669 |
NDR1 |
0.807 | -0.031 | -3 | 0.668 |
BMPR1A |
0.807 | 0.158 | 1 | 0.790 |
MLK2 |
0.807 | 0.049 | 2 | 0.817 |
NIM1 |
0.807 | 0.004 | 3 | 0.813 |
DLK |
0.806 | -0.022 | 1 | 0.859 |
ACVR2A |
0.806 | 0.092 | -2 | 0.813 |
TTBK2 |
0.806 | -0.064 | 2 | 0.746 |
BCKDK |
0.806 | -0.042 | -1 | 0.747 |
YSK4 |
0.805 | 0.073 | 1 | 0.793 |
CHAK2 |
0.805 | -0.016 | -1 | 0.753 |
IRE2 |
0.804 | 0.046 | 2 | 0.822 |
ALK2 |
0.804 | 0.100 | -2 | 0.828 |
PRKD1 |
0.803 | -0.009 | -3 | 0.655 |
WNK3 |
0.803 | -0.108 | 1 | 0.803 |
PKCG |
0.803 | 0.060 | 2 | 0.807 |
P70S6KB |
0.803 | -0.013 | -3 | 0.607 |
AMPKA1 |
0.803 | 0.001 | -3 | 0.669 |
MEKK1 |
0.803 | 0.111 | 1 | 0.815 |
PKR |
0.802 | 0.061 | 1 | 0.808 |
ICK |
0.802 | -0.020 | -3 | 0.658 |
IRE1 |
0.802 | -0.010 | 1 | 0.774 |
RIPK1 |
0.802 | -0.077 | 1 | 0.826 |
PKACG |
0.801 | -0.002 | -2 | 0.758 |
PKCH |
0.800 | 0.046 | 2 | 0.804 |
ZAK |
0.800 | 0.079 | 1 | 0.817 |
LATS2 |
0.800 | -0.038 | -5 | 0.676 |
AURA |
0.800 | 0.074 | -2 | 0.666 |
PKCB |
0.800 | 0.062 | 2 | 0.797 |
PLK3 |
0.800 | 0.018 | 2 | 0.723 |
DRAK1 |
0.800 | 0.039 | 1 | 0.826 |
ATM |
0.800 | -0.028 | 1 | 0.713 |
MSK2 |
0.799 | -0.016 | -3 | 0.587 |
PHKG1 |
0.799 | 0.017 | -3 | 0.645 |
MEKK2 |
0.799 | 0.086 | 2 | 0.813 |
VRK2 |
0.799 | -0.017 | 1 | 0.862 |
PIM1 |
0.798 | -0.021 | -3 | 0.624 |
TSSK1 |
0.798 | 0.016 | -3 | 0.685 |
TLK2 |
0.798 | 0.026 | 1 | 0.750 |
PAK1 |
0.798 | 0.013 | -2 | 0.759 |
NEK2 |
0.798 | -0.015 | 2 | 0.831 |
RSK4 |
0.798 | 0.012 | -3 | 0.594 |
AURC |
0.797 | 0.066 | -2 | 0.683 |
NUAK1 |
0.796 | -0.002 | -3 | 0.599 |
PKCZ |
0.796 | 0.031 | 2 | 0.818 |
MARK2 |
0.796 | 0.079 | 4 | 0.805 |
CAMK4 |
0.796 | -0.065 | -3 | 0.625 |
TSSK2 |
0.796 | -0.043 | -5 | 0.676 |
CAMK2D |
0.796 | -0.081 | -3 | 0.634 |
MST3 |
0.796 | 0.098 | 2 | 0.859 |
MEKK3 |
0.796 | -0.025 | 1 | 0.838 |
PAK3 |
0.795 | -0.016 | -2 | 0.761 |
QSK |
0.795 | 0.035 | 4 | 0.854 |
HIPK4 |
0.795 | -0.020 | 1 | 0.740 |
PRP4 |
0.795 | 0.045 | -3 | 0.691 |
SGK3 |
0.795 | 0.022 | -3 | 0.579 |
CDK8 |
0.794 | -0.013 | 1 | 0.639 |
GRK2 |
0.794 | -0.019 | -2 | 0.692 |
MYLK4 |
0.794 | -0.002 | -2 | 0.776 |
NEK5 |
0.794 | 0.053 | 1 | 0.825 |
MEK1 |
0.794 | -0.141 | 2 | 0.788 |
MARK3 |
0.794 | 0.069 | 4 | 0.847 |
CAMK2B |
0.794 | -0.022 | 2 | 0.667 |
MELK |
0.794 | -0.029 | -3 | 0.610 |
MNK2 |
0.793 | 0.003 | -2 | 0.798 |
SIK |
0.793 | 0.007 | -3 | 0.580 |
P38A |
0.793 | 0.024 | 1 | 0.705 |
AMPKA2 |
0.793 | -0.025 | -3 | 0.642 |
QIK |
0.793 | -0.051 | -3 | 0.620 |
HRI |
0.792 | -0.016 | -2 | 0.856 |
PAK2 |
0.792 | -0.009 | -2 | 0.749 |
PERK |
0.792 | -0.026 | -2 | 0.847 |
CDK5 |
0.792 | 0.032 | 1 | 0.653 |
AURB |
0.792 | 0.041 | -2 | 0.685 |
CHAK1 |
0.792 | -0.037 | 2 | 0.786 |
PRKD2 |
0.792 | -0.042 | -3 | 0.592 |
SRPK1 |
0.791 | -0.031 | -3 | 0.597 |
CDK18 |
0.791 | 0.022 | 1 | 0.571 |
CDK1 |
0.791 | 0.018 | 1 | 0.603 |
MSK1 |
0.791 | 0.002 | -3 | 0.579 |
PKG2 |
0.790 | 0.024 | -2 | 0.696 |
PKCT |
0.790 | 0.049 | 2 | 0.805 |
IRAK4 |
0.790 | 0.020 | 1 | 0.790 |
MEK5 |
0.790 | -0.095 | 2 | 0.820 |
NEK8 |
0.790 | 0.032 | 2 | 0.851 |
BRAF |
0.789 | -0.018 | -4 | 0.761 |
TAO3 |
0.789 | 0.044 | 1 | 0.814 |
TLK1 |
0.789 | -0.012 | -2 | 0.834 |
SMMLCK |
0.789 | 0.005 | -3 | 0.624 |
JNK3 |
0.789 | 0.005 | 1 | 0.631 |
MAPKAPK3 |
0.789 | -0.100 | -3 | 0.587 |
ERK1 |
0.788 | 0.012 | 1 | 0.624 |
MNK1 |
0.788 | -0.019 | -2 | 0.801 |
CLK4 |
0.788 | 0.000 | -3 | 0.584 |
CDK19 |
0.788 | -0.012 | 1 | 0.600 |
MST2 |
0.788 | 0.094 | 1 | 0.814 |
CK1E |
0.788 | -0.026 | -3 | 0.520 |
ERK2 |
0.787 | -0.005 | 1 | 0.658 |
DCAMKL1 |
0.787 | -0.037 | -3 | 0.605 |
CAMK2A |
0.787 | -0.048 | 2 | 0.686 |
PRKD3 |
0.787 | -0.057 | -3 | 0.556 |
AKT2 |
0.787 | 0.004 | -3 | 0.511 |
P38B |
0.787 | 0.018 | 1 | 0.640 |
PKACB |
0.787 | 0.021 | -2 | 0.703 |
CDK17 |
0.787 | 0.012 | 1 | 0.522 |
SRPK2 |
0.787 | -0.024 | -3 | 0.527 |
CAMK1G |
0.787 | -0.042 | -3 | 0.566 |
MARK1 |
0.786 | 0.013 | 4 | 0.847 |
DYRK2 |
0.786 | -0.026 | 1 | 0.674 |
SRPK3 |
0.786 | -0.041 | -3 | 0.588 |
WNK4 |
0.786 | -0.048 | -2 | 0.841 |
P38G |
0.786 | 0.012 | 1 | 0.522 |
NEK11 |
0.786 | -0.008 | 1 | 0.816 |
PHKG2 |
0.785 | -0.009 | -3 | 0.588 |
CDK2 |
0.785 | -0.024 | 1 | 0.691 |
SNRK |
0.785 | -0.102 | 2 | 0.724 |
CLK1 |
0.785 | -0.002 | -3 | 0.548 |
CDK13 |
0.785 | -0.034 | 1 | 0.613 |
MAPKAPK2 |
0.785 | -0.055 | -3 | 0.565 |
DCAMKL2 |
0.784 | -0.038 | -3 | 0.599 |
GRK3 |
0.784 | -0.018 | -2 | 0.650 |
JNK2 |
0.784 | 0.002 | 1 | 0.596 |
SMG1 |
0.783 | -0.106 | 1 | 0.718 |
TTBK1 |
0.783 | -0.097 | 2 | 0.674 |
PLK2 |
0.783 | 0.027 | -3 | 0.650 |
BRSK1 |
0.783 | -0.039 | -3 | 0.610 |
PASK |
0.783 | -0.034 | -3 | 0.697 |
GAK |
0.782 | 0.032 | 1 | 0.825 |
PIM2 |
0.782 | -0.029 | -3 | 0.556 |
BRSK2 |
0.782 | -0.048 | -3 | 0.612 |
CK1A2 |
0.782 | -0.020 | -3 | 0.476 |
HIPK1 |
0.782 | -0.005 | 1 | 0.689 |
IRAK1 |
0.782 | -0.073 | -1 | 0.643 |
AKT1 |
0.782 | 0.021 | -3 | 0.522 |
PAK6 |
0.782 | -0.008 | -2 | 0.711 |
PINK1 |
0.781 | -0.124 | 1 | 0.768 |
EEF2K |
0.781 | 0.053 | 3 | 0.772 |
CDK14 |
0.781 | 0.007 | 1 | 0.613 |
CDK7 |
0.781 | -0.047 | 1 | 0.639 |
GSK3A |
0.781 | 0.016 | 4 | 0.405 |
CHK1 |
0.780 | -0.083 | -3 | 0.635 |
PDK1 |
0.780 | -0.004 | 1 | 0.832 |
PKCI |
0.780 | 0.009 | 2 | 0.814 |
CDK16 |
0.780 | 0.031 | 1 | 0.535 |
TAO2 |
0.780 | -0.008 | 2 | 0.855 |
CK1D |
0.780 | -0.031 | -3 | 0.479 |
DAPK3 |
0.779 | 0.010 | -3 | 0.618 |
MAP3K15 |
0.779 | 0.032 | 1 | 0.806 |
CDK12 |
0.779 | -0.030 | 1 | 0.590 |
PKCE |
0.779 | 0.037 | 2 | 0.808 |
DNAPK |
0.779 | -0.077 | 1 | 0.640 |
DYRK1A |
0.778 | -0.033 | 1 | 0.708 |
TTK |
0.778 | 0.152 | -2 | 0.844 |
MINK |
0.777 | 0.043 | 1 | 0.793 |
GSK3B |
0.777 | -0.021 | 4 | 0.397 |
CK2A2 |
0.777 | 0.055 | 1 | 0.691 |
P70S6K |
0.777 | -0.047 | -3 | 0.518 |
GCK |
0.777 | 0.026 | 1 | 0.798 |
PKACA |
0.776 | 0.011 | -2 | 0.659 |
PRKX |
0.776 | 0.010 | -3 | 0.525 |
MST1 |
0.776 | 0.043 | 1 | 0.794 |
CK1G1 |
0.776 | -0.055 | -3 | 0.534 |
ERK7 |
0.776 | 0.055 | 2 | 0.602 |
CAMKK1 |
0.776 | -0.079 | -2 | 0.756 |
MAPKAPK5 |
0.776 | -0.133 | -3 | 0.525 |
CLK2 |
0.776 | 0.015 | -3 | 0.583 |
HIPK2 |
0.775 | -0.007 | 1 | 0.577 |
CDK3 |
0.775 | 0.011 | 1 | 0.539 |
NEK4 |
0.775 | -0.057 | 1 | 0.781 |
HIPK3 |
0.775 | -0.035 | 1 | 0.703 |
DAPK1 |
0.774 | 0.000 | -3 | 0.608 |
CAMKK2 |
0.774 | -0.065 | -2 | 0.754 |
PKN1 |
0.774 | 0.005 | -3 | 0.512 |
OSR1 |
0.773 | 0.121 | 2 | 0.793 |
CDK9 |
0.773 | -0.051 | 1 | 0.626 |
RIPK2 |
0.773 | -0.076 | 1 | 0.793 |
HGK |
0.773 | 0.009 | 3 | 0.807 |
P38D |
0.773 | 0.007 | 1 | 0.517 |
MEKK6 |
0.772 | -0.021 | 1 | 0.816 |
TNIK |
0.772 | 0.033 | 3 | 0.789 |
VRK1 |
0.772 | -0.020 | 2 | 0.840 |
YSK1 |
0.772 | 0.058 | 2 | 0.847 |
TAK1 |
0.772 | -0.039 | 1 | 0.810 |
AKT3 |
0.772 | 0.017 | -3 | 0.470 |
DYRK1B |
0.772 | -0.025 | 1 | 0.621 |
SSTK |
0.771 | -0.048 | 4 | 0.826 |
NEK1 |
0.770 | -0.032 | 1 | 0.806 |
CAMK1D |
0.770 | -0.062 | -3 | 0.499 |
DYRK3 |
0.770 | -0.023 | 1 | 0.693 |
LKB1 |
0.769 | -0.090 | -3 | 0.672 |
PAK4 |
0.769 | 0.002 | -2 | 0.659 |
SGK1 |
0.769 | -0.001 | -3 | 0.454 |
DYRK4 |
0.768 | -0.026 | 1 | 0.597 |
MPSK1 |
0.768 | -0.072 | 1 | 0.763 |
PAK5 |
0.768 | -0.018 | -2 | 0.645 |
CK2A1 |
0.767 | 0.034 | 1 | 0.671 |
CHK2 |
0.767 | -0.045 | -3 | 0.448 |
HPK1 |
0.766 | -0.042 | 1 | 0.781 |
CAMK1A |
0.766 | -0.030 | -3 | 0.488 |
JNK1 |
0.766 | -0.017 | 1 | 0.576 |
LRRK2 |
0.766 | -0.113 | 2 | 0.855 |
LOK |
0.766 | -0.032 | -2 | 0.761 |
CDK10 |
0.765 | -0.010 | 1 | 0.598 |
MAK |
0.765 | 0.022 | -2 | 0.663 |
MRCKB |
0.765 | -0.008 | -3 | 0.555 |
ROCK2 |
0.764 | -0.007 | -3 | 0.609 |
STK33 |
0.763 | -0.122 | 2 | 0.656 |
KHS1 |
0.763 | 0.001 | 1 | 0.768 |
NEK3 |
0.762 | -0.026 | 1 | 0.789 |
MEK2 |
0.762 | -0.164 | 2 | 0.791 |
KHS2 |
0.761 | 0.004 | 1 | 0.772 |
SLK |
0.760 | -0.071 | -2 | 0.697 |
MRCKA |
0.760 | -0.043 | -3 | 0.565 |
CDK6 |
0.758 | -0.028 | 1 | 0.593 |
DMPK1 |
0.758 | 0.005 | -3 | 0.567 |
ASK1 |
0.757 | -0.012 | 1 | 0.794 |
MYO3A |
0.756 | 0.029 | 1 | 0.752 |
MYO3B |
0.756 | 0.032 | 2 | 0.848 |
YANK3 |
0.755 | -0.043 | 2 | 0.420 |
CDK4 |
0.754 | -0.035 | 1 | 0.567 |
TAO1 |
0.752 | -0.016 | 1 | 0.753 |
PBK |
0.752 | -0.061 | 1 | 0.752 |
BUB1 |
0.752 | -0.028 | -5 | 0.655 |
ROCK1 |
0.751 | -0.015 | -3 | 0.570 |
MOK |
0.751 | -0.024 | 1 | 0.724 |
ALPHAK3 |
0.751 | -0.041 | -1 | 0.727 |
PKG1 |
0.749 | -0.020 | -2 | 0.604 |
STLK3 |
0.749 | -0.028 | 1 | 0.780 |
CRIK |
0.747 | -0.034 | -3 | 0.526 |
HASPIN |
0.745 | -0.061 | -1 | 0.582 |
SBK |
0.745 | -0.073 | -3 | 0.397 |
CK1A |
0.742 | -0.059 | -3 | 0.423 |
PDHK3_TYR |
0.742 | 0.089 | 4 | 0.819 |
BIKE |
0.741 | -0.036 | 1 | 0.702 |
EPHA6 |
0.740 | 0.159 | -1 | 0.815 |
BMPR2_TYR |
0.740 | 0.103 | -1 | 0.826 |
EPHB4 |
0.739 | 0.167 | -1 | 0.789 |
MAP2K6_TYR |
0.737 | 0.045 | -1 | 0.811 |
MAP2K4_TYR |
0.735 | 0.003 | -1 | 0.797 |
JAK3 |
0.734 | 0.159 | 1 | 0.829 |
PDHK4_TYR |
0.734 | 0.028 | 2 | 0.808 |
PKMYT1_TYR |
0.734 | -0.001 | 3 | 0.882 |
MAP2K7_TYR |
0.734 | -0.062 | 2 | 0.830 |
FGR |
0.733 | 0.103 | 1 | 0.882 |
INSRR |
0.732 | 0.123 | 3 | 0.823 |
PDHK1_TYR |
0.732 | -0.008 | -1 | 0.811 |
ROS1 |
0.732 | 0.116 | 3 | 0.816 |
TESK1_TYR |
0.732 | -0.046 | 3 | 0.870 |
PINK1_TYR |
0.732 | -0.042 | 1 | 0.851 |
RET |
0.731 | 0.043 | 1 | 0.819 |
TYK2 |
0.730 | 0.078 | 1 | 0.813 |
KDR |
0.730 | 0.115 | 3 | 0.834 |
MST1R |
0.730 | 0.059 | 3 | 0.862 |
PDGFRB |
0.730 | 0.117 | 3 | 0.851 |
CSF1R |
0.730 | 0.085 | 3 | 0.846 |
TYRO3 |
0.729 | 0.052 | 3 | 0.828 |
JAK2 |
0.729 | 0.061 | 1 | 0.818 |
TXK |
0.729 | 0.110 | 1 | 0.861 |
FER |
0.729 | 0.060 | 1 | 0.868 |
LCK |
0.729 | 0.134 | -1 | 0.715 |
EPHB3 |
0.729 | 0.115 | -1 | 0.769 |
DDR1 |
0.728 | 0.029 | 4 | 0.763 |
BLK |
0.728 | 0.153 | -1 | 0.718 |
FGFR2 |
0.728 | 0.084 | 3 | 0.872 |
EPHB1 |
0.728 | 0.101 | 1 | 0.881 |
YES1 |
0.728 | 0.059 | -1 | 0.703 |
ABL2 |
0.728 | 0.093 | -1 | 0.695 |
EPHB2 |
0.727 | 0.102 | -1 | 0.771 |
HCK |
0.727 | 0.082 | -1 | 0.707 |
TNNI3K_TYR |
0.726 | 0.140 | 1 | 0.845 |
CK1G3 |
0.726 | -0.073 | -3 | 0.393 |
FLT3 |
0.725 | 0.077 | 3 | 0.825 |
FGFR1 |
0.725 | 0.093 | 3 | 0.849 |
FLT1 |
0.725 | 0.094 | -1 | 0.809 |
ITK |
0.725 | 0.080 | -1 | 0.686 |
YANK2 |
0.725 | -0.066 | 2 | 0.425 |
LIMK1_TYR |
0.725 | -0.047 | 2 | 0.847 |
ABL1 |
0.724 | 0.070 | -1 | 0.680 |
EPHA4 |
0.724 | 0.035 | 2 | 0.714 |
LIMK2_TYR |
0.724 | -0.032 | -3 | 0.706 |
NTRK1 |
0.724 | 0.064 | -1 | 0.756 |
INSR |
0.724 | 0.106 | 3 | 0.800 |
KIT |
0.724 | 0.044 | 3 | 0.854 |
AAK1 |
0.723 | -0.006 | 1 | 0.598 |
FYN |
0.723 | 0.088 | -1 | 0.700 |
MERTK |
0.723 | 0.059 | 3 | 0.837 |
MET |
0.722 | 0.061 | 3 | 0.849 |
DDR2 |
0.722 | 0.142 | 3 | 0.850 |
NTRK2 |
0.722 | 0.081 | 3 | 0.835 |
ALK |
0.722 | 0.070 | 3 | 0.818 |
EPHA7 |
0.722 | 0.075 | 2 | 0.737 |
NTRK3 |
0.721 | 0.074 | -1 | 0.713 |
FLT4 |
0.721 | 0.060 | 3 | 0.831 |
FGFR3 |
0.720 | 0.057 | 3 | 0.855 |
LTK |
0.720 | 0.064 | 3 | 0.841 |
SRMS |
0.720 | 0.023 | 1 | 0.869 |
JAK1 |
0.720 | 0.066 | 1 | 0.782 |
TNK2 |
0.720 | 0.048 | 3 | 0.844 |
AXL |
0.719 | 0.033 | 3 | 0.849 |
PTK2 |
0.719 | 0.123 | -1 | 0.806 |
TEC |
0.719 | 0.038 | -1 | 0.607 |
EPHA3 |
0.719 | 0.033 | 2 | 0.716 |
BMX |
0.718 | 0.029 | -1 | 0.618 |
LYN |
0.716 | 0.053 | 3 | 0.804 |
ERBB2 |
0.716 | -0.012 | 1 | 0.789 |
PDGFRA |
0.716 | -0.006 | 3 | 0.840 |
TNK1 |
0.715 | 0.004 | 3 | 0.813 |
CK1G2 |
0.715 | -0.059 | -3 | 0.470 |
EPHA5 |
0.715 | 0.071 | 2 | 0.705 |
EPHA8 |
0.715 | 0.055 | -1 | 0.750 |
BTK |
0.715 | -0.034 | -1 | 0.621 |
TEK |
0.714 | -0.026 | 3 | 0.804 |
FRK |
0.714 | 0.016 | -1 | 0.714 |
SRC |
0.713 | 0.036 | -1 | 0.679 |
EPHA1 |
0.713 | 0.034 | 3 | 0.829 |
PTK2B |
0.713 | 0.037 | -1 | 0.646 |
EGFR |
0.713 | 0.026 | 1 | 0.725 |
IGF1R |
0.712 | 0.058 | 3 | 0.763 |
SYK |
0.711 | 0.071 | -1 | 0.764 |
WEE1_TYR |
0.710 | -0.050 | -1 | 0.652 |
PTK6 |
0.710 | -0.070 | -1 | 0.614 |
MATK |
0.709 | -0.025 | -1 | 0.637 |
FGFR4 |
0.708 | 0.015 | -1 | 0.710 |
EPHA2 |
0.705 | 0.058 | -1 | 0.743 |
NEK10_TYR |
0.705 | -0.079 | 1 | 0.694 |
ERBB4 |
0.703 | 0.028 | 1 | 0.723 |
MUSK |
0.700 | -0.025 | 1 | 0.713 |
CSK |
0.700 | -0.075 | 2 | 0.740 |
FES |
0.695 | -0.011 | -1 | 0.597 |
ZAP70 |
0.691 | 0.014 | -1 | 0.686 |