Motif 962 (n=127)

Position-wise Probabilities
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uniprot genes site source protein function
B1ANS9 WDR64 S886 ochoa WD repeat-containing protein 64 None
B2RTY4 MYO9A S1240 ochoa Unconventional myosin-IXa (Unconventional myosin-9a) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
H0YGG7 None S22 ochoa ADP-ribosylation factor 1 None
O00159 MYO1C S29 ochoa Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}.
O00429 DNM1L S40 psp Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.
O14933 UBE2L6 S27 ochoa Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6) Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. {ECO:0000269|PubMed:15131269, ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20508617}.
O43900 PRICKLE3 S122 ochoa Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}.
O60318 MCM3AP S579 ochoa Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}.
O60664 PLIN3 S175 ochoa Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
O75122 CLASP2 S1053 ochoa|psp CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O94806 PRKD3 S731 ochoa|psp Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
O95155 UBE4B S238 ochoa Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}.
O95400 CD2BP2 S151 ochoa CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}.
O96018 APBA3 S46 ochoa Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}.
P01258 CALCA S43 ochoa Calcitonin [Cleaved into: Calcitonin (CT); Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)] [Calcitonin]: Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex (PubMed:35324283). {ECO:0000269|PubMed:35324283}.; FUNCTION: [Katacalcin]: Katacalcin is a potent plasma calcium-lowering peptide. {ECO:0000269|PubMed:6132180}.
P04921 GYPC S104 ochoa Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236) This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
P13639 EEF2 S325 ochoa Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
P13796 LCP1 S418 ochoa Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}.
P13804 ETFA S140 ochoa Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}.
P15923 TCF3 S391 ochoa Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}.
P17174 GOT1 S66 ochoa Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}.
P18085 ARF4 S147 ochoa ADP-ribosylation factor 4 GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000269|PubMed:25673879}.
P19429 TNNI3 S42 psp Troponin I, cardiac muscle (Cardiac troponin I) Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
P20839 IMPDH1 S160 ochoa Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
P22314 UBA1 S56 ochoa Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}.
P28347 TEAD1 S36 ochoa Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
P31689 DNAJA1 S335 ochoa DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
P31943 HNRNPH1 S104 ochoa|psp Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
P32298 GRK4 S419 psp G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.
P33981 TTK S345 psp Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P36402 TCF7 S37 ochoa Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1) Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. {ECO:0000250|UniProtKB:Q00417}.
P41240 CSK S364 psp Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
P48751 SLC4A3 S1121 ochoa Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}.
P49116 NR2C2 S55 ochoa Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}.
P52597 HNRNPF S104 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P55795 HNRNPH2 S104 ochoa|psp Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
P61204 ARF3 S147 ochoa ADP-ribosylation factor 3 GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
P78347 GTF2I S19 ochoa General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
P84077 ARF1 S147 ochoa ADP-ribosylation factor 1 (EC 3.6.5.2) Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:P84079, ECO:0000269|PubMed:8253837}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.
Q05209 PTPN12 S449 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q06830 PRDX1 S152 ochoa Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}.
Q07157 TJP1 S810 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q13043 STK4 S438 ochoa|psp Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}.
Q13131 PRKAA1 S356 ochoa 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
Q13405 MRPL49 S41 ochoa Large ribosomal subunit protein mL49 (39S ribosomal protein L49, mitochondrial) (L49mt) (MRP-L49) (Neighbor of FAU) (NOF) (Protein NOF1) None
Q13501 SQSTM1 S366 ochoa|psp Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q13813 SPTAN1 S484 ochoa Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Q14160 SCRIB S37 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14997 PSME4 S1614 ochoa Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10) Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}.
Q15051 IQCB1 S572 ochoa IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655). {ECO:0000269|PubMed:23446637, ECO:0000269|PubMed:25552655}.
Q15139 PRKD1 S738 ochoa|psp Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}.
Q2M2I8 AAK1 S797 ochoa AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}.
Q5BKX8 CAVIN4 S346 ochoa Caveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein) Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000250|UniProtKB:A2AMM0, ECO:0000269|PubMed:18332105}.
Q5H9R7 PPP6R3 S579 ochoa Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}.
Q5JSH3 WDR44 S871 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q5JUK3 KCNT1 S407 psp Potassium channel subfamily T member 1 (KCa4.1) (KNa1.1) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2) Sodium-activated K(+) channel (PubMed:37494189). Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity). Regulates neuronal bursting in sensory neurons (By similarity). Contributes to synaptic development and plasticity (By similarity). {ECO:0000250|UniProtKB:Q6ZPR4, ECO:0000250|UniProtKB:Q9Z258, ECO:0000269|PubMed:37494189}.
Q5SQS7 SH2D4B S361 ochoa SH2 domain-containing protein 4B None
Q5SSJ5 HP1BP3 S377 ochoa Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}.
Q5SXM2 SNAPC4 S68 ochoa snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
Q5SXM2 SNAPC4 S1400 ochoa snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
Q5T5X7 BEND3 S54 ochoa BEN domain-containing protein 3 Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}.
Q5VTT5 MYOM3 S240 ochoa Myomesin-3 (Myomesin family member 3) May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}.
Q684P5 RAP1GAP2 S34 ochoa Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}.
Q6NXG1 ESRP1 S74 ochoa Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250|UniProtKB:Q3US41, ECO:0000269|PubMed:19285943}.
Q6NXT6 TAPT1 S542 ochoa Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7, ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}.; FUNCTION: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. {ECO:0000269|PubMed:10640539}.
Q6P9B6 MEAK7 S425 ochoa MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). {ECO:0000269|PubMed:29750193}.
Q7L4P6 BEND5 S53 ochoa BEN domain-containing protein 5 Acts as a transcriptional repressor (PubMed:23468431). {ECO:0000269|PubMed:23468431}.
Q7Z3G6 PRICKLE2 S66 ochoa Prickle-like protein 2 None
Q86VF7 NRAP S1482 ochoa Nebulin-related-anchoring protein (N-RAP) May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}.
Q86VR2 RETREG3 S373 ochoa Reticulophagy regulator 3 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}.
Q86YS6 RAB43 S193 ochoa Ras-related protein Rab-43 (Ras-related protein Rab-41) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057, ECO:0000269|PubMed:18664496, ECO:0000269|PubMed:21255211}.
Q86Z02 HIPK1 S38 ochoa Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}.
Q8IX12 CCAR1 S994 ochoa Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.
Q8N3D4 EHBP1L1 S1123 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8NFJ5 GPRC5A S59 ochoa Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}.
Q8NFU5 IPMK S348 ochoa Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}.
Q8NI35 PATJ S645 ochoa InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}.
Q8TEW0 PARD3 S852 ochoa Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
Q8TF05 PPP4R1 S442 ochoa Serine/threonine-protein phosphatase 4 regulatory subunit 1 Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}.
Q8WZ75 ROBO4 S564 ochoa Roundabout homolog 4 (Magic roundabout) Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}.
Q92556 ELMO1 S580 ochoa Engulfment and cell motility protein 1 (Protein ced-12 homolog) Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}.
Q92835 INPP5D S170 ochoa Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}.
Q96BY6 DOCK10 S302 ochoa Dedicator of cytokinesis protein 10 (Zizimin-3) Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.
Q96CT7 CCDC124 S194 ochoa Coiled-coil domain-containing protein 124 Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage (PubMed:32687489). Also required for proper progression of late cytokinetic stages (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:32687489}.
Q96IT1 ZNF496 S188 ochoa Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}.
Q96MT3 PRICKLE1 S62 ochoa Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.
Q96PK6 RBM14 S627 ochoa RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}.
Q96Q07 BTBD9 S577 ochoa BTB/POZ domain-containing protein 9 None
Q96QB1 DLC1 S1296 ochoa Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}.
Q99459 CDC5L S358 ochoa|psp Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}.
Q9BTT6 LRRC1 S37 ochoa Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein) None
Q9BXM7 PINK1 S402 psp Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1) Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress. It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:18957282, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20547144, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:24898855, PubMed:25527291, PubMed:32484300). Depending on the severity of mitochondrial damage, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to eliminating severely damaged mitochondria via PINK1-PRKN-dependent mitophagy (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24898855, PubMed:32047033, PubMed:32484300). When cellular stress results in irreversible mitochondrial damage, PINK1 accumulates at the outer mitochondrial membrane (OMM) where it phosphorylates pre-existing polyubiquitin chains at 'Ser-65', recruits PRKN from the cytosol to the OMM and activates PRKN by phosphorylation at 'Ser-65'; activated PRKN then ubiquinates VDAC1 and other OMM proteins to initiate mitophagy (PubMed:14607334, PubMed:15087508, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria through phosphorylation and PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128). {ECO:0000250|UniProtKB:Q99MQ3, ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18443288, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20547144, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:24898855, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:29123128, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:32484300}.
Q9BXW9 FANCD2 S717 ochoa|psp Fanconi anemia group D2 protein (Protein FACD2) Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}.
Q9BZL6 PRKD2 S706 ochoa|psp Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}.
Q9H0K1 SIK2 S379 ochoa Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}.
Q9H1A4 ANAPC1 S547 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H4A5 GOLPH3L S112 ochoa Golgi phosphoprotein 3-like (GPP34-related protein) Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}.
Q9H7P9 PLEKHG2 S911 ochoa Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
Q9NPG3 UBN1 S142 ochoa Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
Q9NRS6 SNX15 S201 ochoa Sorting nexin-15 May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}.
Q9NUU7 DDX19A S92 ochoa ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A) ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}.
Q9NWS6 FAM118A S311 ochoa Protein FAM118A None
Q9NYF8 BCLAF1 S564 ochoa Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9NZ09 UBAP1 S217 ochoa Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}.
Q9NZN5 ARHGEF12 S1176 ochoa Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.
Q9UHB9 SRP68 S267 ochoa Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38687, ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}.
Q9UIG0 BAZ1B S508 ochoa Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}.
Q9UL54 TAOK2 S656 ochoa Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}.
Q9UMR2 DDX19B S93 ochoa|psp ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B) ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269|PubMed:10428971}.
Q9UQ35 SRRM2 S1349 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQB8 BAIAP2 S453 ochoa|psp BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
Q9Y4W6 AFG3L2 S765 ochoa Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein) Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (PubMed:19748354, PubMed:28396416, PubMed:29932645, PubMed:30683687, PubMed:31327635, PubMed:37917749, PubMed:38157846). AFG3L2 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (PubMed:19748354, PubMed:31327635). The m-AAA protease carries out quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides (PubMed:26504172, PubMed:30683687, PubMed:34718584). The m-AAA protease complex also promotes the processing and maturation of mitochondrial proteins, such as MRPL32/bL32m, PINK1 and SP7 (PubMed:22354088, PubMed:29932645, PubMed:30252181). Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (PubMed:29932645). Required for SPG7 maturation into its active mature form after SPG7 cleavage by mitochondrial-processing peptidase (MPP) (PubMed:30252181). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048, PubMed:28396416). Promotes the proteolytic degradation of GHITM upon hyperpolarization of mitochondria: progressive GHITM degradation leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (PubMed:35912435). Also acts as a regulator of mitochondrial glutathione homeostasis by mediating cleavage and degradation of SLC25A39 (PubMed:37917749, PubMed:38157846). SLC25A39 cleavage is prevented when SLC25A39 binds iron-sulfur (PubMed:37917749, PubMed:38157846). Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:17615298, PubMed:29545505, PubMed:30252181, PubMed:30683687, PubMed:32600459). May act by mediating processing of OMA1 precursor, participating in OMA1 maturation (PubMed:29545505). {ECO:0000269|PubMed:17615298, ECO:0000269|PubMed:19748354, ECO:0000269|PubMed:22354088, ECO:0000269|PubMed:26504172, ECO:0000269|PubMed:27642048, ECO:0000269|PubMed:28396416, ECO:0000269|PubMed:29545505, ECO:0000269|PubMed:29932645, ECO:0000269|PubMed:30252181, ECO:0000269|PubMed:30683687, ECO:0000269|PubMed:31327635, ECO:0000269|PubMed:32600459, ECO:0000269|PubMed:34718584, ECO:0000269|PubMed:35912435, ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846}.
Q9Y5K6 CD2AP S458 ochoa CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.
Q9Y6B6 SAR1B S162 ochoa Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B) Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII (PubMed:23433038, PubMed:32358066, PubMed:33186557, PubMed:36369712). The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:23433038, PubMed:32358066, PubMed:33186557). In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis (PubMed:32358066, PubMed:33186557). In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B (PubMed:34290409). {ECO:0000269|PubMed:23433038, ECO:0000269|PubMed:32358066, ECO:0000269|PubMed:33186557, ECO:0000269|PubMed:34290409, ECO:0000269|PubMed:36369712}.
Q9Y6E2 BZW2 S205 ochoa eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2) Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). {ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:28981728, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}.
P11586 MTHFD1 S129 Sugiyama C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}.
P39687 ANP32A S117 Sugiyama Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}.
Q92688 ANP32B S117 Sugiyama Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}.
P51811 XK S63 ELM Endoplasmic reticulum membrane adapter protein XK (Kell complex 37 kDa component) (Kx antigen) (Membrane transport protein XK) (XK-related protein 1) Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. {ECO:0000269|PubMed:32845802}.
Q99613 EIF3C S639 Sugiyama Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
P32119 PRDX2 S151 Sugiyama Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}.
Q16222 UAP1 S496 Sugiyama UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23) Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579). {ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:9603950, ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). {ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). {ECO:0000269|PubMed:9765219}.
Q9Y5J9 TIMM8B S50 Sugiyama Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2) Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). {ECO:0000250}.
Q16288 NTRK3 S706 Sugiyama NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.
P27824 CANX S74 Sugiyama Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
P62714 PPP2CB S75 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}.
P67775 PPP2CA S75 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}.
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reactome_id name p -log10_p
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.000059 4.230
R-HSA-447115 Interleukin-12 family signaling 0.000030 4.521
R-HSA-419812 Calcitonin-like ligand receptors 0.000148 3.831
R-HSA-9020591 Interleukin-12 signaling 0.000126 3.899
R-HSA-199977 ER to Golgi Anterograde Transport 0.000800 3.097
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.001399 2.854
R-HSA-5654738 Signaling by FGFR2 0.001289 2.890
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.003795 2.421
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 0.003795 2.421
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.007266 2.139
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.007266 2.139
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.007266 2.139
R-HSA-5339716 Signaling by GSK3beta mutants 0.008293 2.081
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.009380 2.028
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.009380 2.028
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.009380 2.028
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.009380 2.028
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.009380 2.028
R-HSA-6803529 FGFR2 alternative splicing 0.002176 2.662
R-HSA-6807878 COPI-mediated anterograde transport 0.002993 2.524
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.005662 2.247
R-HSA-4641265 Repression of WNT target genes 0.009380 2.028
R-HSA-69618 Mitotic Spindle Checkpoint 0.003495 2.457
R-HSA-8951430 RUNX3 regulates WNT signaling 0.003795 2.421
R-HSA-4839744 Signaling by APC mutants 0.007266 2.139
R-HSA-202670 ERKs are inactivated 0.008293 2.081
R-HSA-4839748 Signaling by AMER1 mutants 0.008293 2.081
R-HSA-4839735 Signaling by AXIN mutants 0.008293 2.081
R-HSA-9612973 Autophagy 0.005173 2.286
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.002458 2.609
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.008293 2.081
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.005402 2.267
R-HSA-199991 Membrane Trafficking 0.007706 2.113
R-HSA-948021 Transport to the Golgi and subsequent modification 0.004095 2.388
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.005402 2.267
R-HSA-190236 Signaling by FGFR 0.003237 2.490
R-HSA-449147 Signaling by Interleukins 0.005826 2.235
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.010703 1.970
R-HSA-141424 Amplification of signal from the kinetochores 0.010703 1.970
R-HSA-196299 Beta-catenin phosphorylation cascade 0.012998 1.886
R-HSA-72163 mRNA Splicing - Major Pathway 0.013136 1.882
R-HSA-1295596 Spry regulation of FGF signaling 0.012998 1.886
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.011734 1.931
R-HSA-9663891 Selective autophagy 0.011890 1.925
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 0.014318 1.844
R-HSA-388841 Regulation of T cell activation by CD28 family 0.012964 1.887
R-HSA-75153 Apoptotic execution phase 0.013182 1.880
R-HSA-1632852 Macroautophagy 0.014649 1.834
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.014863 1.828
R-HSA-1280218 Adaptive Immune System 0.015963 1.797
R-HSA-72172 mRNA Splicing 0.016419 1.785
R-HSA-5602566 TICAM1 deficiency - HSE 0.017849 1.748
R-HSA-2028269 Signaling by Hippo 0.017124 1.766
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.018607 1.730
R-HSA-432142 Platelet sensitization by LDL 0.018607 1.730
R-HSA-389513 Co-inhibition by CTLA4 0.021730 1.663
R-HSA-2467813 Separation of Sister Chromatids 0.025105 1.600
R-HSA-113510 E2F mediated regulation of DNA replication 0.020143 1.696
R-HSA-373753 Nephrin family interactions 0.021730 1.663
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.024455 1.612
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.025053 1.601
R-HSA-198753 ERK/MAPK targets 0.023367 1.631
R-HSA-446203 Asparagine N-linked glycosylation 0.019418 1.712
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.024050 1.619
R-HSA-109581 Apoptosis 0.024090 1.618
R-HSA-9603505 NTRK3 as a dependence receptor 0.026654 1.574
R-HSA-5602571 TRAF3 deficiency - HSE 0.026654 1.574
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.028568 1.544
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.028888 1.539
R-HSA-9034013 NTF3 activates NTRK3 signaling 0.035382 1.451
R-HSA-9615710 Late endosomal microautophagy 0.040192 1.396
R-HSA-420029 Tight junction interactions 0.032268 1.491
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.038148 1.419
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.038148 1.419
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.040192 1.396
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.034473 1.463
R-HSA-2132295 MHC class II antigen presentation 0.036072 1.443
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.036146 1.442
R-HSA-5653656 Vesicle-mediated transport 0.037177 1.430
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.034185 1.466
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.037400 1.427
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.043357 1.363
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.029824 1.525
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.030396 1.517
R-HSA-8863678 Neurodegenerative Diseases 0.030396 1.517
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.036146 1.442
R-HSA-180024 DARPP-32 events 0.040192 1.396
R-HSA-168256 Immune System 0.037218 1.429
R-HSA-9008059 Interleukin-37 signaling 0.042277 1.374
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.034473 1.463
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.040192 1.396
R-HSA-3700989 Transcriptional Regulation by TP53 0.032491 1.488
R-HSA-212436 Generic Transcription Pathway 0.043860 1.358
R-HSA-9034793 Activated NTRK3 signals through PLCG1 0.044031 1.356
R-HSA-111446 Activation of BIM and translocation to mitochondria 0.044031 1.356
R-HSA-8856688 Golgi-to-ER retrograde transport 0.045624 1.341
R-HSA-9833482 PKR-mediated signaling 0.045865 1.339
R-HSA-4791275 Signaling by WNT in cancer 0.046565 1.332
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.046565 1.332
R-HSA-162582 Signal Transduction 0.047506 1.323
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.048767 1.312
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.048767 1.312
R-HSA-389948 Co-inhibition by PD-1 0.048944 1.310
R-HSA-3858494 Beta-catenin independent WNT signaling 0.050390 1.298
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.051005 1.292
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 0.052603 1.279
R-HSA-191650 Regulation of gap junction activity 0.052603 1.279
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.053280 1.273
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.053280 1.273
R-HSA-5205647 Mitophagy 0.053280 1.273
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.054394 1.264
R-HSA-195721 Signaling by WNT 0.068828 1.162
R-HSA-68882 Mitotic Anaphase 0.063236 1.199
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.060315 1.220
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.064143 1.193
R-HSA-5673000 RAF activation 0.053280 1.273
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.067402 1.171
R-HSA-373080 Class B/2 (Secretin family receptors) 0.060898 1.215
R-HSA-6804757 Regulation of TP53 Degradation 0.057936 1.237
R-HSA-168316 Assembly of Viral Components at the Budding Site 0.061099 1.214
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.065172 1.186
R-HSA-73857 RNA Polymerase II Transcription 0.056721 1.246
R-HSA-5357801 Programmed Cell Death 0.053745 1.270
R-HSA-1280215 Cytokine Signaling in Immune system 0.069255 1.160
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 0.077865 1.109
R-HSA-9603381 Activated NTRK3 signals through PI3K 0.086136 1.065
R-HSA-2562578 TRIF-mediated programmed cell death 0.086136 1.065
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.094333 1.025
R-HSA-9613354 Lipophagy 0.102457 0.989
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 0.110509 0.957
R-HSA-9034864 Activated NTRK3 signals through RAS 0.118489 0.926
R-HSA-5358493 Synthesis of diphthamide-EEF2 0.126398 0.898
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.126398 0.898
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.142006 0.848
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.157336 0.803
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.157336 0.803
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.157336 0.803
R-HSA-176412 Phosphorylation of the APC/C 0.164899 0.783
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.164899 0.783
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.194482 0.711
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.194482 0.711
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.208881 0.680
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.105226 0.978
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.119753 0.922
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.140851 0.851
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.126398 0.898
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.172394 0.763
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.127156 0.896
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.179823 0.745
R-HSA-8949664 Processing of SMDT1 0.142006 0.848
R-HSA-4608870 Asymmetric localization of PCP proteins 0.083126 1.080
R-HSA-6802957 Oncogenic MAPK signaling 0.204546 0.689
R-HSA-209560 NF-kB is activated and signals survival 0.126398 0.898
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.142006 0.848
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.172394 0.763
R-HSA-5620916 VxPx cargo-targeting to cilium 0.201714 0.695
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.143463 0.843
R-HSA-9613829 Chaperone Mediated Autophagy 0.187185 0.728
R-HSA-193639 p75NTR signals via NF-kB 0.157336 0.803
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.073095 1.136
R-HSA-209543 p75NTR recruits signalling complexes 0.134237 0.872
R-HSA-204005 COPII-mediated vesicle transport 0.156371 0.806
R-HSA-392517 Rap1 signalling 0.194482 0.711
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.159513 0.797
R-HSA-1855191 Synthesis of IPs in the nucleus 0.149705 0.825
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.149705 0.825
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.171320 0.766
R-HSA-166166 MyD88-independent TLR4 cascade 0.098601 1.006
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.089737 1.047
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.098601 1.006
R-HSA-9706019 RHOBTB3 ATPase cycle 0.118489 0.926
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.157336 0.803
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.172394 0.763
R-HSA-9664407 Parasite infection 0.169123 0.772
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.169123 0.772
R-HSA-9664417 Leishmania phagocytosis 0.169123 0.772
R-HSA-68877 Mitotic Prometaphase 0.125585 0.901
R-HSA-9664873 Pexophagy 0.110509 0.957
R-HSA-205043 NRIF signals cell death from the nucleus 0.149705 0.825
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.201714 0.695
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.158691 0.799
R-HSA-201681 TCF dependent signaling in response to WNT 0.110549 0.956
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.086136 1.065
R-HSA-425381 Bicarbonate transporters 0.118489 0.926
R-HSA-9796292 Formation of axial mesoderm 0.142006 0.848
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.157336 0.803
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.088505 1.053
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.189177 0.723
R-HSA-438064 Post NMDA receptor activation events 0.214384 0.669
R-HSA-164944 Nef and signal transduction 0.077865 1.109
R-HSA-5336415 Uptake and function of diphtheria toxin 0.086136 1.065
R-HSA-167590 Nef Mediated CD4 Down-regulation 0.086136 1.065
R-HSA-8963888 Chylomicron assembly 0.118489 0.926
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.149705 0.825
R-HSA-416482 G alpha (12/13) signalling events 0.181816 0.740
R-HSA-3928664 Ephrin signaling 0.187185 0.728
R-HSA-9754189 Germ layer formation at gastrulation 0.194482 0.711
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.150123 0.824
R-HSA-193704 p75 NTR receptor-mediated signalling 0.077930 1.108
R-HSA-5654743 Signaling by FGFR4 0.077853 1.109
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.202871 0.693
R-HSA-5578768 Physiological factors 0.149705 0.825
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.164899 0.783
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.179823 0.745
R-HSA-4086400 PCP/CE pathway 0.181816 0.740
R-HSA-5654741 Signaling by FGFR3 0.083126 1.080
R-HSA-5673001 RAF/MAP kinase cascade 0.147758 0.830
R-HSA-9659379 Sensory processing of sound 0.185040 0.733
R-HSA-977225 Amyloid fiber formation 0.191513 0.718
R-HSA-9020956 Interleukin-27 signaling 0.110509 0.957
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.109683 0.960
R-HSA-5684996 MAPK1/MAPK3 signaling 0.157638 0.802
R-HSA-5654736 Signaling by FGFR1 0.113883 0.944
R-HSA-210990 PECAM1 interactions 0.118489 0.926
R-HSA-9856872 Malate-aspartate shuttle 0.149705 0.825
R-HSA-1237112 Methionine salvage pathway 0.194482 0.711
R-HSA-193648 NRAGE signals death through JNK 0.113883 0.944
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.150123 0.824
R-HSA-9834899 Specification of the neural plate border 0.194482 0.711
R-HSA-8878159 Transcriptional regulation by RUNX3 0.074692 1.127
R-HSA-9683686 Maturation of spike protein 0.110509 0.957
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.134237 0.872
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.113883 0.944
R-HSA-166520 Signaling by NTRKs 0.189177 0.723
R-HSA-69236 G1 Phase 0.080476 1.094
R-HSA-69231 Cyclin D associated events in G1 0.080476 1.094
R-HSA-5683057 MAPK family signaling cascades 0.115316 0.938
R-HSA-8876725 Protein methylation 0.157336 0.803
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.164899 0.783
R-HSA-389356 Co-stimulation by CD28 0.091233 1.040
R-HSA-9711123 Cellular response to chemical stress 0.119834 0.921
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.094333 1.025
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.102457 0.989
R-HSA-373755 Semaphorin interactions 0.134742 0.870
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.187185 0.728
R-HSA-180292 GAB1 signalosome 0.187185 0.728
R-HSA-9706369 Negative regulation of FLT3 0.164899 0.783
R-HSA-69620 Cell Cycle Checkpoints 0.107506 0.969
R-HSA-8984722 Interleukin-35 Signalling 0.134237 0.872
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.162668 0.789
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.211099 0.676
R-HSA-73887 Death Receptor Signaling 0.202871 0.693
R-HSA-4086398 Ca2+ pathway 0.165834 0.780
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.210072 0.678
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.095020 1.022
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 0.179823 0.745
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.111576 0.952
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.131710 0.880
R-HSA-6794362 Protein-protein interactions at synapses 0.204546 0.689
R-HSA-5675221 Negative regulation of MAPK pathway 0.072692 1.139
R-HSA-194138 Signaling by VEGF 0.133190 0.876
R-HSA-1500931 Cell-Cell communication 0.084373 1.074
R-HSA-168268 Virus Assembly and Release 0.164899 0.783
R-HSA-74160 Gene expression (Transcription) 0.083376 1.079
R-HSA-1483255 PI Metabolism 0.082901 1.081
R-HSA-5633007 Regulation of TP53 Activity 0.078125 1.107
R-HSA-177929 Signaling by EGFR 0.113883 0.944
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.095013 1.022
R-HSA-450294 MAP kinase activation 0.128696 0.890
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.113883 0.944
R-HSA-448424 Interleukin-17 signaling 0.156371 0.806
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.096800 1.014
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.104083 0.983
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.109683 0.960
R-HSA-446652 Interleukin-1 family signaling 0.198280 0.703
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.162668 0.789
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.215984 0.666
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.215984 0.666
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.215984 0.666
R-HSA-8949215 Mitochondrial calcium ion transport 0.215984 0.666
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.215984 0.666
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.215984 0.666
R-HSA-175474 Assembly Of The HIV Virion 0.215984 0.666
R-HSA-9645723 Diseases of programmed cell death 0.217674 0.662
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.223024 0.652
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.224266 0.649
R-HSA-421270 Cell-cell junction organization 0.228714 0.641
R-HSA-912526 Interleukin receptor SHC signaling 0.230002 0.638
R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 0.230002 0.638
R-HSA-8963898 Plasma lipoprotein assembly 0.236917 0.625
R-HSA-9620244 Long-term potentiation 0.243770 0.613
R-HSA-9839394 TGFBR3 expression 0.243770 0.613
R-HSA-400685 Sema4D in semaphorin signaling 0.243770 0.613
R-HSA-418555 G alpha (s) signalling events 0.245188 0.611
R-HSA-525793 Myogenesis 0.250562 0.601
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.250562 0.601
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.252382 0.598
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.257294 0.590
R-HSA-445095 Interaction between L1 and Ankyrins 0.257294 0.590
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.257294 0.590
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.257294 0.590
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.257409 0.589
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.257409 0.589
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.257409 0.589
R-HSA-9614085 FOXO-mediated transcription 0.260732 0.584
R-HSA-6798695 Neutrophil degranulation 0.262259 0.581
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.263965 0.578
R-HSA-171319 Telomere Extension By Telomerase 0.263965 0.578
R-HSA-70171 Glycolysis 0.264056 0.578
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.270577 0.568
R-HSA-5656169 Termination of translesion DNA synthesis 0.270577 0.568
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.270704 0.568
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.277130 0.557
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.277130 0.557
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.277130 0.557
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.277130 0.557
R-HSA-8863795 Downregulation of ERBB2 signaling 0.277130 0.557
R-HSA-114452 Activation of BH3-only proteins 0.277130 0.557
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.277130 0.557
R-HSA-111885 Opioid Signalling 0.277351 0.557
R-HSA-69275 G2/M Transition 0.281437 0.551
R-HSA-446728 Cell junction organization 0.281580 0.550
R-HSA-162588 Budding and maturation of HIV virion 0.283625 0.547
R-HSA-8963693 Aspartate and asparagine metabolism 0.283625 0.547
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.283625 0.547
R-HSA-5694530 Cargo concentration in the ER 0.283625 0.547
R-HSA-182971 EGFR downregulation 0.283625 0.547
R-HSA-453274 Mitotic G2-G2/M phases 0.286313 0.543
R-HSA-418346 Platelet homeostasis 0.287315 0.542
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.289586 0.538
R-HSA-9675126 Diseases of mitotic cell cycle 0.290061 0.538
R-HSA-5617833 Cilium Assembly 0.291196 0.536
R-HSA-168898 Toll-like Receptor Cascades 0.293640 0.532
R-HSA-354192 Integrin signaling 0.296440 0.528
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.296440 0.528
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.296440 0.528
R-HSA-68886 M Phase 0.298163 0.526
R-HSA-202403 TCR signaling 0.300577 0.522
R-HSA-390522 Striated Muscle Contraction 0.302763 0.519
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.302763 0.519
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.302763 0.519
R-HSA-1483249 Inositol phosphate metabolism 0.307194 0.513
R-HSA-901042 Calnexin/calreticulin cycle 0.309028 0.510
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.309028 0.510
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.315238 0.501
R-HSA-428157 Sphingolipid metabolism 0.318140 0.497
R-HSA-432720 Lysosome Vesicle Biogenesis 0.321393 0.493
R-HSA-74158 RNA Polymerase III Transcription 0.321393 0.493
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.321393 0.493
R-HSA-9845576 Glycosphingolipid transport 0.321393 0.493
R-HSA-163560 Triglyceride catabolism 0.321393 0.493
R-HSA-8941326 RUNX2 regulates bone development 0.321393 0.493
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.327492 0.485
R-HSA-196757 Metabolism of folate and pterines 0.327492 0.485
R-HSA-70326 Glucose metabolism 0.330250 0.481
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.333537 0.477
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.336801 0.473
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.336801 0.473
R-HSA-68875 Mitotic Prophase 0.340070 0.468
R-HSA-9646399 Aggrephagy 0.345466 0.462
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.345466 0.462
R-HSA-5260271 Diseases of Immune System 0.345466 0.462
R-HSA-451927 Interleukin-2 family signaling 0.345466 0.462
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.346593 0.460
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.346593 0.460
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.351351 0.454
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 0.351351 0.454
R-HSA-9694548 Maturation of spike protein 0.351351 0.454
R-HSA-8853884 Transcriptional Regulation by VENTX 0.351351 0.454
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.351351 0.454
R-HSA-9607240 FLT3 Signaling 0.351351 0.454
R-HSA-162909 Host Interactions of HIV factors 0.353095 0.452
R-HSA-5674135 MAP2K and MAPK activation 0.357183 0.447
R-HSA-9656223 Signaling by RAF1 mutants 0.357183 0.447
R-HSA-6811438 Intra-Golgi traffic 0.357183 0.447
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.357183 0.447
R-HSA-9683701 Translation of Structural Proteins 0.357183 0.447
R-HSA-69206 G1/S Transition 0.359574 0.444
R-HSA-165159 MTOR signalling 0.362963 0.440
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.362963 0.440
R-HSA-8953854 Metabolism of RNA 0.365592 0.437
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.369249 0.433
R-HSA-9907900 Proteasome assembly 0.374368 0.427
R-HSA-6783310 Fanconi Anemia Pathway 0.379995 0.420
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.379995 0.420
R-HSA-8878171 Transcriptional regulation by RUNX1 0.381777 0.418
R-HSA-5576891 Cardiac conduction 0.382060 0.418
R-HSA-162906 HIV Infection 0.384207 0.415
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.385571 0.414
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.385571 0.414
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.385571 0.414
R-HSA-9649948 Signaling downstream of RAS mutants 0.385571 0.414
R-HSA-6802949 Signaling by RAS mutants 0.385571 0.414
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.385571 0.414
R-HSA-9839373 Signaling by TGFBR3 0.385571 0.414
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.385571 0.414
R-HSA-9705683 SARS-CoV-2-host interactions 0.386635 0.413
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.391097 0.408
R-HSA-5620924 Intraflagellar transport 0.396575 0.402
R-HSA-163685 Integration of energy metabolism 0.401068 0.397
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.402003 0.396
R-HSA-157858 Gap junction trafficking and regulation 0.402003 0.396
R-HSA-73893 DNA Damage Bypass 0.402003 0.396
R-HSA-9748787 Azathioprine ADME 0.407382 0.390
R-HSA-2514856 The phototransduction cascade 0.412714 0.384
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.417998 0.379
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.417998 0.379
R-HSA-6794361 Neurexins and neuroligins 0.417998 0.379
R-HSA-5339562 Uptake and actions of bacterial toxins 0.417998 0.379
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.423235 0.373
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.423235 0.373
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.423235 0.373
R-HSA-8956320 Nucleotide biosynthesis 0.423235 0.373
R-HSA-9694516 SARS-CoV-2 Infection 0.425485 0.371
R-HSA-72649 Translation initiation complex formation 0.428424 0.368
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.428424 0.368
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.433568 0.363
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.433568 0.363
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.435183 0.361
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.438666 0.358
R-HSA-72702 Ribosomal scanning and start codon recognition 0.438666 0.358
R-HSA-5578775 Ion homeostasis 0.438666 0.358
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.438666 0.358
R-HSA-168249 Innate Immune System 0.442610 0.354
R-HSA-9758941 Gastrulation 0.444309 0.352
R-HSA-9856651 MITF-M-dependent gene expression 0.447332 0.349
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.448724 0.348
R-HSA-180786 Extension of Telomeres 0.453687 0.343
R-HSA-8979227 Triglyceride metabolism 0.453687 0.343
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.453687 0.343
R-HSA-8873719 RAB geranylgeranylation 0.458604 0.339
R-HSA-1227986 Signaling by ERBB2 0.458604 0.339
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.458604 0.339
R-HSA-375165 NCAM signaling for neurite out-growth 0.468308 0.329
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.468308 0.329
R-HSA-1268020 Mitochondrial protein import 0.468308 0.329
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.468308 0.329
R-HSA-186797 Signaling by PDGF 0.468308 0.329
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.473095 0.325
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.473095 0.325
R-HSA-8848021 Signaling by PTK6 0.473095 0.325
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.473095 0.325
R-HSA-9006936 Signaling by TGFB family members 0.477056 0.321
R-HSA-8854518 AURKA Activation by TPX2 0.487201 0.312
R-HSA-5693606 DNA Double Strand Break Response 0.491819 0.308
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.505427 0.296
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.505427 0.296
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.509882 0.293
R-HSA-453276 Regulation of mitotic cell cycle 0.509882 0.293
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.509882 0.293
R-HSA-9658195 Leishmania infection 0.510549 0.292
R-HSA-9824443 Parasitic Infection Pathways 0.510549 0.292
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.514297 0.289
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.517008 0.287
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.517008 0.287
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.518673 0.285
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.518673 0.285
R-HSA-69052 Switching of origins to a post-replicative state 0.518673 0.285
R-HSA-380287 Centrosome maturation 0.527307 0.278
R-HSA-1169408 ISG15 antiviral mechanism 0.527307 0.278
R-HSA-8852135 Protein ubiquitination 0.527307 0.278
R-HSA-611105 Respiratory electron transport 0.530784 0.275
R-HSA-9694635 Translation of Structural Proteins 0.535787 0.271
R-HSA-2559583 Cellular Senescence 0.536220 0.271
R-HSA-372790 Signaling by GPCR 0.537436 0.270
R-HSA-383280 Nuclear Receptor transcription pathway 0.539971 0.268
R-HSA-1257604 PIP3 activates AKT signaling 0.541134 0.267
R-HSA-1483257 Phospholipid metabolism 0.541134 0.267
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.544117 0.264
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.548225 0.261
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.556333 0.255
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.564296 0.248
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.564296 0.248
R-HSA-5687128 MAPK6/MAPK4 signaling 0.568224 0.245
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.572117 0.243
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.575975 0.240
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.575975 0.240
R-HSA-1614635 Sulfur amino acid metabolism 0.575975 0.240
R-HSA-388396 GPCR downstream signalling 0.577925 0.238
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.578144 0.238
R-HSA-72766 Translation 0.579508 0.237
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.583588 0.234
R-HSA-156902 Peptide chain elongation 0.583588 0.234
R-HSA-9824446 Viral Infection Pathways 0.589477 0.230
R-HSA-202424 Downstream TCR signaling 0.591066 0.228
R-HSA-1852241 Organelle biogenesis and maintenance 0.592942 0.227
R-HSA-9679506 SARS-CoV Infections 0.595269 0.225
R-HSA-2262752 Cellular responses to stress 0.595931 0.225
R-HSA-156842 Eukaryotic Translation Elongation 0.602032 0.220
R-HSA-2682334 EPH-Ephrin signaling 0.602032 0.220
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.602032 0.220
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.602032 0.220
R-HSA-68867 Assembly of the pre-replicative complex 0.605622 0.218
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.609180 0.215
R-HSA-9837999 Mitochondrial protein degradation 0.609180 0.215
R-HSA-8953897 Cellular responses to stimuli 0.609462 0.215
R-HSA-69278 Cell Cycle, Mitotic 0.612064 0.213
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.612706 0.213
R-HSA-72689 Formation of a pool of free 40S subunits 0.616201 0.210
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.619605 0.208
R-HSA-397014 Muscle contraction 0.619605 0.208
R-HSA-5389840 Mitochondrial translation elongation 0.619664 0.208
R-HSA-9730414 MITF-M-regulated melanocyte development 0.621945 0.206
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.623096 0.205
R-HSA-157579 Telomere Maintenance 0.623096 0.205
R-HSA-5368286 Mitochondrial translation initiation 0.626498 0.203
R-HSA-418990 Adherens junctions interactions 0.633477 0.198
R-HSA-9006925 Intracellular signaling by second messengers 0.635326 0.197
R-HSA-9675108 Nervous system development 0.635769 0.197
R-HSA-9020702 Interleukin-1 signaling 0.636520 0.196
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.643053 0.192
R-HSA-112316 Neuronal System 0.644884 0.191
R-HSA-1640170 Cell Cycle 0.645440 0.190
R-HSA-9860931 Response of endothelial cells to shear stress 0.646275 0.190
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.646275 0.190
R-HSA-9833110 RSV-host interactions 0.649469 0.187
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.658879 0.181
R-HSA-69239 Synthesis of DNA 0.658879 0.181
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.658879 0.181
R-HSA-9700206 Signaling by ALK in cancer 0.658879 0.181
R-HSA-597592 Post-translational protein modification 0.660007 0.180
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.661960 0.179
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.661960 0.179
R-HSA-5419276 Mitochondrial translation termination 0.665013 0.177
R-HSA-69002 DNA Replication Pre-Initiation 0.665013 0.177
R-HSA-73894 DNA Repair 0.667677 0.175
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.674008 0.171
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.674008 0.171
R-HSA-202733 Cell surface interactions at the vascular wall 0.674816 0.171
R-HSA-1643685 Disease 0.677129 0.169
R-HSA-9855142 Cellular responses to mechanical stimuli 0.679872 0.168
R-HSA-72737 Cap-dependent Translation Initiation 0.691286 0.160
R-HSA-72613 Eukaryotic Translation Initiation 0.691286 0.160
R-HSA-373760 L1CAM interactions 0.691286 0.160
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.696841 0.157
R-HSA-8878166 Transcriptional regulation by RUNX2 0.699581 0.155
R-HSA-9609646 HCMV Infection 0.700880 0.154
R-HSA-392499 Metabolism of proteins 0.703024 0.153
R-HSA-73886 Chromosome Maintenance 0.704987 0.152
R-HSA-913531 Interferon Signaling 0.707515 0.150
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.735455 0.133
R-HSA-109582 Hemostasis 0.736752 0.133
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.751763 0.124
R-HSA-422475 Axon guidance 0.753323 0.123
R-HSA-5368287 Mitochondrial translation 0.754010 0.123
R-HSA-162599 Late Phase of HIV Life Cycle 0.764944 0.116
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.764944 0.116
R-HSA-8856828 Clathrin-mediated endocytosis 0.767072 0.115
R-HSA-2187338 Visual phototransduction 0.775395 0.110
R-HSA-69242 S Phase 0.777429 0.109
R-HSA-5663205 Infectious disease 0.779966 0.108
R-HSA-9679191 Potential therapeutics for SARS 0.781443 0.107
R-HSA-9609507 Protein localization 0.787329 0.104
R-HSA-69306 DNA Replication 0.787329 0.104
R-HSA-5693532 DNA Double-Strand Break Repair 0.787329 0.104
R-HSA-9610379 HCMV Late Events 0.794933 0.100
R-HSA-162587 HIV Life Cycle 0.794933 0.100
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.794933 0.100
R-HSA-500792 GPCR ligand binding 0.802929 0.095
R-HSA-112315 Transmission across Chemical Synapses 0.816845 0.088
R-HSA-212165 Epigenetic regulation of gene expression 0.816845 0.088
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.827522 0.082
R-HSA-9678108 SARS-CoV-1 Infection 0.827522 0.082
R-HSA-168255 Influenza Infection 0.833698 0.079
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.838488 0.077
R-HSA-375276 Peptide ligand-binding receptors 0.843981 0.074
R-HSA-9609690 HCMV Early Events 0.857586 0.067
R-HSA-376176 Signaling by ROBO receptors 0.866401 0.062
R-HSA-9748784 Drug ADME 0.884568 0.053
R-HSA-8951664 Neddylation 0.887690 0.052
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.896563 0.047
R-HSA-418594 G alpha (i) signalling events 0.900226 0.046
R-HSA-15869 Metabolism of nucleotides 0.902087 0.045
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.930142 0.031
R-HSA-76002 Platelet activation, signaling and aggregation 0.930872 0.031
R-HSA-8957322 Metabolism of steroids 0.956331 0.019
R-HSA-556833 Metabolism of lipids 0.966929 0.015
R-HSA-196854 Metabolism of vitamins and cofactors 0.969792 0.013
R-HSA-9824439 Bacterial Infection Pathways 0.976457 0.010
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.977311 0.010
R-HSA-425407 SLC-mediated transmembrane transport 0.977932 0.010
R-HSA-382551 Transport of small molecules 0.981819 0.008
R-HSA-71291 Metabolism of amino acids and derivatives 0.997180 0.001
R-HSA-1266738 Developmental Biology 0.997816 0.001
R-HSA-9709957 Sensory Perception 0.999334 0.000
R-HSA-1430728 Metabolism 0.999983 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.843 0.278 1 0.838
COTCOT 0.835 0.075 2 0.724
CAMK2GCAMK2G 0.832 0.246 2 0.803
SRPK1SRPK1 0.831 0.198 -3 0.699
NLKNLK 0.830 0.221 1 0.889
MTORMTOR 0.829 0.079 1 0.845
DSTYKDSTYK 0.826 0.050 2 0.758
CDKL1CDKL1 0.824 0.098 -3 0.741
SRPK2SRPK2 0.824 0.164 -3 0.624
MST4MST4 0.824 0.097 2 0.708
PKN3PKN3 0.822 0.069 -3 0.767
WNK1WNK1 0.822 0.103 -2 0.778
CAMK2DCAMK2D 0.821 0.178 -3 0.776
GCN2GCN2 0.821 -0.063 2 0.705
PDHK4PDHK4 0.821 -0.037 1 0.853
IKKBIKKB 0.820 0.002 -2 0.680
TBK1TBK1 0.820 0.036 1 0.787
NDR2NDR2 0.820 0.076 -3 0.761
CDK8CDK8 0.820 0.199 1 0.791
PRKD1PRKD1 0.820 0.094 -3 0.767
CDK13CDK13 0.820 0.237 1 0.779
CDC7CDC7 0.820 -0.021 1 0.760
RAF1RAF1 0.820 -0.014 1 0.833
MOSMOS 0.819 0.038 1 0.800
CAMK2ACAMK2A 0.819 0.230 2 0.829
PRPKPRPK 0.819 -0.058 -1 0.798
SRPK3SRPK3 0.819 0.161 -3 0.668
CAMK2BCAMK2B 0.819 0.217 2 0.798
LATS2LATS2 0.818 0.143 -5 0.785
PRKD2PRKD2 0.818 0.095 -3 0.708
ERK5ERK5 0.818 0.103 1 0.784
NEK6NEK6 0.818 0.012 -2 0.768
ULK2ULK2 0.818 -0.058 2 0.640
CAMK1BCAMK1B 0.817 0.010 -3 0.783
ICKICK 0.817 0.137 -3 0.769
HIPK4HIPK4 0.817 0.125 1 0.844
PIM3PIM3 0.817 0.028 -3 0.753
IKKEIKKE 0.817 0.031 1 0.782
DYRK2DYRK2 0.817 0.219 1 0.813
CDKL5CDKL5 0.816 0.070 -3 0.738
CHAK2CHAK2 0.816 0.065 -1 0.897
GRK1GRK1 0.816 0.094 -2 0.730
CDK19CDK19 0.815 0.190 1 0.763
JNK2JNK2 0.815 0.250 1 0.763
RSK2RSK2 0.815 0.052 -3 0.711
BMPR2BMPR2 0.815 -0.026 -2 0.813
PKCDPKCD 0.814 0.085 2 0.671
CLK2CLK2 0.814 0.192 -3 0.680
CDK5CDK5 0.814 0.225 1 0.793
CDK1CDK1 0.814 0.223 1 0.747
JNK3JNK3 0.814 0.238 1 0.787
PIM1PIM1 0.814 0.090 -3 0.703
PDHK1PDHK1 0.814 -0.058 1 0.852
PRP4PRP4 0.814 0.403 -3 0.932
NEK7NEK7 0.814 -0.072 -3 0.779
KISKIS 0.814 0.126 1 0.807
BCKDKBCKDK 0.814 0.006 -1 0.795
CDK12CDK12 0.813 0.238 1 0.764
NUAK2NUAK2 0.813 0.023 -3 0.756
ATRATR 0.813 -0.010 1 0.794
PKN2PKN2 0.813 0.027 -3 0.767
FAM20CFAM20C 0.813 0.059 2 0.562
MAPKAPK2MAPKAPK2 0.813 0.088 -3 0.651
CLK1CLK1 0.812 0.146 -3 0.681
MAPKAPK3MAPKAPK3 0.812 0.044 -3 0.707
NIKNIK 0.812 0.014 -3 0.802
CLK4CLK4 0.811 0.129 -3 0.704
DNAPKDNAPK 0.811 0.174 1 0.762
GRK6GRK6 0.811 0.073 1 0.775
NDR1NDR1 0.811 0.010 -3 0.758
CDK18CDK18 0.811 0.222 1 0.730
MNK2MNK2 0.810 0.078 -2 0.696
CDK7CDK7 0.810 0.178 1 0.791
RIPK3RIPK3 0.809 -0.030 3 0.663
P90RSKP90RSK 0.809 0.022 -3 0.724
MLK1MLK1 0.809 -0.052 2 0.673
ULK1ULK1 0.809 -0.100 -3 0.759
IKKAIKKA 0.809 0.033 -2 0.675
CDK9CDK9 0.808 0.199 1 0.787
ATMATM 0.808 0.039 1 0.745
CDK3CDK3 0.808 0.225 1 0.703
HIPK2HIPK2 0.807 0.214 1 0.751
TGFBR2TGFBR2 0.807 -0.038 -2 0.739
GRK5GRK5 0.807 -0.070 -3 0.767
PKACGPKACG 0.806 0.026 -2 0.645
WNK3WNK3 0.806 -0.107 1 0.804
MARK4MARK4 0.806 -0.033 4 0.792
SKMLCKSKMLCK 0.806 0.010 -2 0.760
NEK9NEK9 0.806 -0.045 2 0.690
ERK1ERK1 0.805 0.207 1 0.748
CDK2CDK2 0.805 0.161 1 0.797
P38AP38A 0.805 0.210 1 0.793
RSK3RSK3 0.805 0.002 -3 0.705
CAMLCKCAMLCK 0.805 -0.027 -2 0.763
P70S6KBP70S6KB 0.805 -0.002 -3 0.727
HUNKHUNK 0.804 -0.108 2 0.628
PKRPKR 0.804 0.135 1 0.793
HIPK1HIPK1 0.804 0.193 1 0.822
P38GP38G 0.804 0.221 1 0.688
PKCAPKCA 0.804 0.058 2 0.614
MNK1MNK1 0.804 0.065 -2 0.711
TSSK2TSSK2 0.804 0.040 -5 0.900
IRE1IRE1 0.803 0.013 1 0.743
AMPKA1AMPKA1 0.803 -0.019 -3 0.777
PKCGPKCG 0.803 0.034 2 0.618
MSK2MSK2 0.803 0.017 -3 0.682
MLK3MLK3 0.803 0.015 2 0.626
LATS1LATS1 0.803 0.072 -3 0.777
DAPK2DAPK2 0.802 -0.045 -3 0.799
ERK2ERK2 0.802 0.190 1 0.783
AURCAURC 0.802 0.036 -2 0.584
DLKDLK 0.802 -0.054 1 0.794
NEK2NEK2 0.802 0.018 2 0.670
P38BP38B 0.802 0.217 1 0.742
PKCBPKCB 0.802 0.033 2 0.620
TSSK1TSSK1 0.801 0.026 -3 0.799
GRK7GRK7 0.801 0.084 1 0.732
RIPK1RIPK1 0.801 -0.068 1 0.783
PRKD3PRKD3 0.801 0.031 -3 0.683
RSK4RSK4 0.801 0.054 -3 0.677
TTBK2TTBK2 0.801 -0.103 2 0.566
PRKXPRKX 0.801 0.109 -3 0.611
CDK17CDK17 0.801 0.194 1 0.693
DYRK4DYRK4 0.800 0.203 1 0.760
CDK10CDK10 0.800 0.217 1 0.760
CDK16CDK16 0.799 0.221 1 0.708
AMPKA2AMPKA2 0.799 -0.011 -3 0.745
DYRK1ADYRK1A 0.799 0.149 1 0.841
MSK1MSK1 0.799 0.050 -3 0.682
ANKRD3ANKRD3 0.799 -0.098 1 0.825
PLK1PLK1 0.798 -0.021 -2 0.726
NUAK1NUAK1 0.798 -0.017 -3 0.711
PKCHPKCH 0.798 0.010 2 0.601
PKCZPKCZ 0.798 0.038 2 0.645
ALK4ALK4 0.798 0.010 -2 0.773
PAK1PAK1 0.798 -0.020 -2 0.693
DYRK3DYRK3 0.798 0.168 1 0.825
PKACBPKACB 0.797 0.053 -2 0.584
TGFBR1TGFBR1 0.797 0.049 -2 0.747
PHKG1PHKG1 0.797 -0.022 -3 0.753
PAK6PAK6 0.797 0.003 -2 0.631
NIM1NIM1 0.796 -0.090 3 0.693
HIPK3HIPK3 0.796 0.156 1 0.834
ALK2ALK2 0.796 0.084 -2 0.756
MLK2MLK2 0.796 -0.093 2 0.668
CDK14CDK14 0.796 0.184 1 0.774
GRK4GRK4 0.796 -0.099 -2 0.746
DYRK1BDYRK1B 0.796 0.179 1 0.776
P38DP38D 0.795 0.219 1 0.713
CHAK1CHAK1 0.795 -0.033 2 0.602
ERK7ERK7 0.795 0.138 2 0.522
PLK3PLK3 0.795 0.010 2 0.684
MASTLMASTL 0.795 -0.234 -2 0.734
CAMK4CAMK4 0.795 -0.079 -3 0.737
YSK4YSK4 0.795 -0.031 1 0.782
SGK3SGK3 0.794 0.025 -3 0.704
IRE2IRE2 0.794 -0.020 2 0.620
MLK4MLK4 0.794 -0.034 2 0.605
BMPR1BBMPR1B 0.794 0.032 1 0.681
PAK3PAK3 0.793 -0.063 -2 0.690
AURBAURB 0.793 0.010 -2 0.578
AKT2AKT2 0.793 0.026 -3 0.632
SMG1SMG1 0.792 -0.019 1 0.755
VRK2VRK2 0.791 -0.082 1 0.851
MAPKAPK5MAPKAPK5 0.791 -0.037 -3 0.674
MELKMELK 0.791 -0.051 -3 0.740
AURAAURA 0.791 0.008 -2 0.557
QIKQIK 0.791 -0.092 -3 0.763
GSK3AGSK3A 0.791 0.117 4 0.475
JNK1JNK1 0.790 0.193 1 0.742
CHK1CHK1 0.790 0.020 -3 0.727
CDK4CDK4 0.790 0.221 1 0.753
CAMK1GCAMK1G 0.790 -0.014 -3 0.697
QSKQSK 0.790 -0.046 4 0.759
TLK2TLK2 0.790 -0.017 1 0.782
CDK6CDK6 0.790 0.215 1 0.761
MYLK4MYLK4 0.789 -0.026 -2 0.675
PHKG2PHKG2 0.789 0.009 -3 0.728
PKG2PKG2 0.789 -0.000 -2 0.593
SIKSIK 0.789 -0.048 -3 0.686
AKT1AKT1 0.788 0.044 -3 0.648
WNK4WNK4 0.788 -0.024 -2 0.771
HRIHRI 0.788 -0.081 -2 0.773
ACVR2AACVR2A 0.788 -0.013 -2 0.740
DCAMKL1DCAMKL1 0.788 -0.002 -3 0.712
TAO3TAO3 0.788 0.061 1 0.795
MEK1MEK1 0.787 -0.161 2 0.682
PINK1PINK1 0.787 -0.042 1 0.817
PLK4PLK4 0.787 -0.069 2 0.482
ACVR2BACVR2B 0.787 -0.017 -2 0.746
MST3MST3 0.787 0.038 2 0.681
BRAFBRAF 0.787 0.002 -4 0.836
PIM2PIM2 0.787 0.017 -3 0.683
MAKMAK 0.787 0.184 -2 0.717
PKCIPKCI 0.786 0.040 2 0.623
PKCTPKCT 0.786 0.006 2 0.607
MARK3MARK3 0.786 -0.046 4 0.726
PERKPERK 0.786 -0.087 -2 0.782
MEKK1MEKK1 0.786 -0.036 1 0.804
MEKK3MEKK3 0.785 -0.079 1 0.789
PAK2PAK2 0.785 -0.074 -2 0.677
BRSK1BRSK1 0.785 -0.066 -3 0.722
TLK1TLK1 0.785 -0.045 -2 0.748
PKACAPKACA 0.784 0.031 -2 0.549
CK2A2CK2A2 0.784 0.162 1 0.575
PKCEPKCE 0.784 0.054 2 0.602
MARK2MARK2 0.784 -0.056 4 0.692
ZAKZAK 0.784 -0.071 1 0.773
BRSK2BRSK2 0.783 -0.093 -3 0.749
IRAK4IRAK4 0.783 -0.023 1 0.756
NEK5NEK5 0.783 -0.018 1 0.792
DCAMKL2DCAMKL2 0.782 -0.024 -3 0.728
MEKK2MEKK2 0.782 -0.042 2 0.659
PASKPASK 0.782 0.043 -3 0.770
DRAK1DRAK1 0.782 -0.110 1 0.691
TAO2TAO2 0.781 0.040 2 0.710
MEK5MEK5 0.781 -0.155 2 0.668
TTBK1TTBK1 0.781 -0.098 2 0.499
TNIKTNIK 0.781 0.120 3 0.835
CAMKK1CAMKK1 0.780 0.006 -2 0.734
SMMLCKSMMLCK 0.780 -0.026 -3 0.752
GSK3BGSK3B 0.780 0.019 4 0.461
GCKGCK 0.780 0.111 1 0.801
HGKHGK 0.780 0.102 3 0.832
CAMK1DCAMK1D 0.779 0.010 -3 0.619
MARK1MARK1 0.779 -0.078 4 0.745
LKB1LKB1 0.779 0.098 -3 0.827
P70S6KP70S6K 0.779 -0.029 -3 0.654
PKN1PKN1 0.778 0.015 -3 0.671
SNRKSNRK 0.778 -0.191 2 0.547
SSTKSSTK 0.778 -0.027 4 0.746
CK1ECK1E 0.778 -0.067 -3 0.458
MOKMOK 0.778 0.152 1 0.784
EEF2KEEF2K 0.778 0.063 3 0.837
CAMKK2CAMKK2 0.777 0.019 -2 0.739
MINKMINK 0.777 0.091 1 0.799
MPSK1MPSK1 0.777 0.004 1 0.742
KHS2KHS2 0.777 0.165 1 0.814
BMPR1ABMPR1A 0.777 0.005 1 0.669
PAK5PAK5 0.776 -0.032 -2 0.567
NEK8NEK8 0.776 -0.078 2 0.674
HPK1HPK1 0.775 0.079 1 0.801
CK2A1CK2A1 0.775 0.141 1 0.550
GRK2GRK2 0.774 -0.111 -2 0.643
NEK11NEK11 0.774 -0.102 1 0.805
KHS1KHS1 0.774 0.130 1 0.810
PDK1PDK1 0.774 -0.020 1 0.811
NEK4NEK4 0.773 -0.022 1 0.790
LRRK2LRRK2 0.772 0.015 2 0.708
GAKGAK 0.772 0.004 1 0.766
AKT3AKT3 0.772 0.025 -3 0.577
MST2MST2 0.772 -0.025 1 0.804
PAK4PAK4 0.771 -0.042 -2 0.578
CHK2CHK2 0.770 0.007 -3 0.582
TAK1TAK1 0.770 -0.010 1 0.810
SGK1SGK1 0.770 0.021 -3 0.558
NEK1NEK1 0.770 0.024 1 0.775
SLKSLK 0.770 0.023 -2 0.644
LOKLOK 0.770 0.006 -2 0.694
MAP3K15MAP3K15 0.769 -0.036 1 0.775
SBKSBK 0.769 0.053 -3 0.520
CK1G1CK1G1 0.769 -0.082 -3 0.455
PLK2PLK2 0.768 -0.014 -3 0.659
STK33STK33 0.768 -0.069 2 0.495
IRAK1IRAK1 0.768 -0.191 -1 0.735
MST1MST1 0.767 0.003 1 0.792
CK1DCK1D 0.767 -0.062 -3 0.412
CAMK1ACAMK1A 0.767 0.002 -3 0.591
MRCKBMRCKB 0.767 0.019 -3 0.676
DAPK3DAPK3 0.766 -0.026 -3 0.725
MRCKAMRCKA 0.766 0.018 -3 0.686
YSK1YSK1 0.766 0.011 2 0.671
MEKK6MEKK6 0.765 -0.082 1 0.766
CK1A2CK1A2 0.764 -0.073 -3 0.410
HASPINHASPIN 0.764 0.053 -1 0.728
ROCK2ROCK2 0.761 0.021 -3 0.720
BUB1BUB1 0.761 0.044 -5 0.835
GRK3GRK3 0.760 -0.106 -2 0.600
DAPK1DAPK1 0.760 -0.045 -3 0.715
VRK1VRK1 0.759 -0.129 2 0.664
DMPK1DMPK1 0.758 0.046 -3 0.685
PDHK3_TYRPDHK3_TYR 0.758 0.272 4 0.862
NEK3NEK3 0.756 -0.059 1 0.769
TAO1TAO1 0.756 0.038 1 0.761
RIPK2RIPK2 0.756 -0.196 1 0.759
MYO3BMYO3B 0.755 0.053 2 0.680
MEK2MEK2 0.753 -0.197 2 0.646
ROCK1ROCK1 0.753 0.011 -3 0.691
PBKPBK 0.752 -0.055 1 0.691
OSR1OSR1 0.751 -0.049 2 0.645
PKG1PKG1 0.751 -0.039 -2 0.529
CRIKCRIK 0.750 0.009 -3 0.642
MYO3AMYO3A 0.749 -0.005 1 0.792
ASK1ASK1 0.749 -0.037 1 0.769
BIKEBIKE 0.748 0.013 1 0.656
PDHK4_TYRPDHK4_TYR 0.748 0.125 2 0.763
TESK1_TYRTESK1_TYR 0.746 0.013 3 0.803
YANK3YANK3 0.746 -0.071 2 0.342
TTKTTK 0.746 -0.050 -2 0.741
ALPHAK3ALPHAK3 0.744 -0.046 -1 0.741
MAP2K7_TYRMAP2K7_TYR 0.744 -0.021 2 0.725
BMPR2_TYRBMPR2_TYR 0.743 0.011 -1 0.828
MAP2K6_TYRMAP2K6_TYR 0.742 -0.005 -1 0.836
PINK1_TYRPINK1_TYR 0.741 -0.079 1 0.805
MAP2K4_TYRMAP2K4_TYR 0.741 -0.068 -1 0.813
LIMK2_TYRLIMK2_TYR 0.740 0.013 -3 0.826
PKMYT1_TYRPKMYT1_TYR 0.739 -0.090 3 0.763
PDHK1_TYRPDHK1_TYR 0.739 -0.004 -1 0.836
EPHA6EPHA6 0.736 -0.013 -1 0.812
TYK2TYK2 0.734 -0.107 1 0.804
LIMK1_TYRLIMK1_TYR 0.734 -0.103 2 0.705
MST1RMST1R 0.732 -0.093 3 0.719
STLK3STLK3 0.732 -0.139 1 0.755
RETRET 0.732 -0.114 1 0.801
AAK1AAK1 0.732 0.036 1 0.557
JAK2JAK2 0.729 -0.111 1 0.804
CK1ACK1A 0.728 -0.097 -3 0.325
JAK3JAK3 0.727 -0.083 1 0.778
ROS1ROS1 0.727 -0.138 3 0.708
DDR1DDR1 0.727 -0.146 4 0.785
EPHB4EPHB4 0.726 -0.113 -1 0.790
NEK10_TYRNEK10_TYR 0.726 -0.036 1 0.716
TNNI3K_TYRTNNI3K_TYR 0.726 -0.004 1 0.786
EPHA4EPHA4 0.725 -0.037 2 0.677
CSF1RCSF1R 0.725 -0.112 3 0.699
TYRO3TYRO3 0.723 -0.178 3 0.724
WEE1_TYRWEE1_TYR 0.722 -0.034 -1 0.710
INSRRINSRR 0.721 -0.111 3 0.669
FLT3FLT3 0.721 -0.121 3 0.720
FGFR2FGFR2 0.720 -0.130 3 0.690
JAK1JAK1 0.719 -0.080 1 0.783
TNK1TNK1 0.719 -0.089 3 0.699
PDGFRBPDGFRB 0.717 -0.173 3 0.716
FERFER 0.717 -0.168 1 0.773
KDRKDR 0.717 -0.129 3 0.655
EPHB1EPHB1 0.716 -0.134 1 0.766
TNK2TNK2 0.716 -0.136 3 0.652
ABL2ABL2 0.716 -0.142 -1 0.738
EPHB3EPHB3 0.716 -0.112 -1 0.774
KITKIT 0.716 -0.141 3 0.694
TEKTEK 0.715 -0.157 3 0.656
SRMSSRMS 0.715 -0.131 1 0.757
EPHB2EPHB2 0.715 -0.114 -1 0.767
HCKHCK 0.714 -0.159 -1 0.720
ITKITK 0.714 -0.137 -1 0.720
EPHA3EPHA3 0.714 -0.093 2 0.653
PDGFRAPDGFRA 0.714 -0.183 3 0.715
EPHA7EPHA7 0.713 -0.085 2 0.666
FGFR1FGFR1 0.713 -0.165 3 0.668
TXKTXK 0.713 -0.094 1 0.705
CK1G3CK1G3 0.712 -0.079 -3 0.280
YANK2YANK2 0.712 -0.092 2 0.361
FLT1FLT1 0.712 -0.095 -1 0.790
LCKLCK 0.712 -0.108 -1 0.723
YES1YES1 0.712 -0.179 -1 0.728
BTKBTK 0.711 -0.178 -1 0.679
ABL1ABL1 0.711 -0.166 -1 0.721
ERBB2ERBB2 0.709 -0.142 1 0.749
BLKBLK 0.709 -0.106 -1 0.734
FGRFGR 0.709 -0.241 1 0.747
BMXBMX 0.709 -0.112 -1 0.653
FGFR3FGFR3 0.709 -0.142 3 0.662
METMET 0.708 -0.153 3 0.676
AXLAXL 0.708 -0.186 3 0.672
NTRK1NTRK1 0.708 -0.184 -1 0.756
TECTEC 0.707 -0.140 -1 0.641
EPHA1EPHA1 0.707 -0.131 3 0.663
FLT4FLT4 0.707 -0.177 3 0.650
EPHA5EPHA5 0.706 -0.071 2 0.666
FRKFRK 0.706 -0.130 -1 0.749
DDR2DDR2 0.705 -0.094 3 0.642
INSRINSR 0.705 -0.173 3 0.657
MERTKMERTK 0.705 -0.180 3 0.663
ALKALK 0.704 -0.203 3 0.631
LTKLTK 0.704 -0.178 3 0.638
EGFREGFR 0.704 -0.075 1 0.659
PTK6PTK6 0.704 -0.226 -1 0.643
EPHA8EPHA8 0.703 -0.099 -1 0.760
NTRK2NTRK2 0.703 -0.203 3 0.654
FYNFYN 0.700 -0.125 -1 0.683
CSKCSK 0.700 -0.131 2 0.664
MATKMATK 0.699 -0.142 -1 0.698
NTRK3NTRK3 0.699 -0.161 -1 0.713
FGFR4FGFR4 0.697 -0.103 -1 0.709
LYNLYN 0.697 -0.179 3 0.634
PTK2PTK2 0.696 -0.069 -1 0.735
SYKSYK 0.695 -0.071 -1 0.720
MUSKMUSK 0.693 -0.135 1 0.644
EPHA2EPHA2 0.691 -0.106 -1 0.735
PTK2BPTK2B 0.691 -0.180 -1 0.672
IGF1RIGF1R 0.690 -0.160 3 0.592
CK1G2CK1G2 0.690 -0.106 -3 0.373
SRCSRC 0.688 -0.193 -1 0.675
ERBB4ERBB4 0.686 -0.096 1 0.655
FESFES 0.672 -0.184 -1 0.617
ZAP70ZAP70 0.664 -0.114 -1 0.673