Motif 961 (n=181)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S640 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NKT7 | RGPD3 | S1593 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MYA2 | CXorf49; | S204 | ochoa | Uncharacterized protein CXorf49 | None |
| H0YC42 | None | S72 | ochoa | Tumor protein D52 | None |
| O00139 | KIF2A | S635 | ochoa | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O00418 | EEF2K | S464 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O14715 | RGPD8 | S1592 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14896 | IRF6 | S47 | ochoa | Interferon regulatory factor 6 (IRF-6) | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}. |
| O14964 | HGS | S315 | ochoa | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
| O14980 | XPO1 | S1031 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15027 | SEC16A | S1810 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15091 | PRORP | S94 | ochoa | Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853, ECO:0000269|PubMed:34715011}. |
| O15259 | NPHP1 | Y349 | psp | Nephrocystin-1 (Juvenile nephronophthisis 1 protein) | Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q9QY53}. |
| O43150 | ASAP2 | S756 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) | Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}. |
| O43318 | MAP3K7 | S389 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O43683 | BUB1 | S618 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60237 | PPP1R12B | S29 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O75122 | CLASP2 | S952 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75914 | PAK3 | S259 | psp | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O95071 | UBR5 | S203 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95394 | PGM3 | S64 | ochoa | Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) | Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}. |
| P04075 | ALDOA | S160 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P06733 | ENO1 | S370 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07814 | EPRS1 | S29 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P09619 | PDGFRB | S254 | psp | Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) | Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}. |
| P0DJD0 | RGPD1 | S1577 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1585 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DPH7 | TUBA3C | S277 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S277 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10809 | HSPD1 | S383 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P13010 | XRCC5 | S694 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13929 | ENO3 | S370 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P16144 | ITGB4 | S809 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16152 | CBR1 | S160 | ochoa | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}. |
| P16333 | NCK1 | S157 | ochoa | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}. |
| P17661 | DES | S82 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P18084 | ITGB5 | S762 | psp | Integrin beta-5 | Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. |
| P21359 | NF1 | S2188 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P27987 | ITPKB | S120 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P30291 | WEE1 | S472 | psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P34932 | HSPA4 | S76 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P38398 | BRCA1 | S1143 | psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41970 | ELK3 | S115 | ochoa | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| P42566 | EPS15 | S847 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P43121 | MCAM | S606 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P46013 | MKI67 | S565 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48634 | PRRC2A | S1106 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49069 | CAMLG | S25 | ochoa | Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250|UniProtKB:P49070, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:32187542, ECO:0000269|PubMed:7522304}. |
| P49327 | FASN | S1421 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49643 | PRIM2 | S476 | ochoa | DNA primase large subunit (DNA primase 58 kDa subunit) (p58) | Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:17893144, PubMed:25550159, PubMed:26975377, PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144, PubMed:25550159). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch. {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P33610, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:9705292}. |
| P49792 | RANBP2 | S2568 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50552 | VASP | S289 | ochoa | Vasodilator-stimulated phosphoprotein (VASP) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| P51114 | FXR1 | S413 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P52907 | CAPZA1 | S106 | ochoa|psp | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| P52948 | NUP98 | S1062 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P60891 | PRPS1 | S285 | psp | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P62805 | H4C1 | S48 | ochoa | Histone H4 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P68363 | TUBA1B | S277 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S277 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78524 | DENND2B | S515 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q01082 | SPTBN1 | S1556 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02487 | DSC2 | S873 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02952 | AKAP12 | S388 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S110 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04864 | REL | S503 | psp | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q12888 | TP53BP1 | S320 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q14156 | EFR3A | S222 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14315 | FLNC | S2448 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14689 | DIP2A | S94 | ochoa | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) | Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}. |
| Q14689 | DIP2A | S138 | ochoa | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) | Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}. |
| Q15049 | MLC1 | S197 | psp | Membrane protein MLC1 (Megalencephalic leukoencephalopathy with subcortical cysts protein 1) | Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers (PubMed:22328087). Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx (PubMed:22328087). May function as regulatory protein of membrane protein complexes such as ion channels (Probable). {ECO:0000269|PubMed:22328087, ECO:0000305|PubMed:22328087}. |
| Q2M2I8 | AAK1 | S937 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q4V328 | GRIPAP1 | S321 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q5BKX8 | CAVIN4 | S346 | ochoa | Caveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein) | Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000250|UniProtKB:A2AMM0, ECO:0000269|PubMed:18332105}. |
| Q5JSL3 | DOCK11 | S296 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5T9C2 | EEIG1 | S204 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5VT52 | RPRD2 | S381 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q658Y4 | FAM91A1 | S671 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q659C4 | LARP1B | S863 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q6BEB4 | SP5 | S22 | ochoa | Transcription factor Sp5 | Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). {ECO:0000250}. |
| Q6PCE3 | PGM2L1 | S175 | ochoa | Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1) | Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors (PubMed:17804405). In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant (PubMed:17804405). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083, ECO:0000269|PubMed:33979636}. |
| Q6PEY2 | TUBA3E | S277 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PL18 | ATAD2 | S61 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q71U36 | TUBA1A | S277 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z3J3 | RGPD4 | S1593 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z4H7 | HAUS6 | S552 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z589 | EMSY | S829 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q7Z591 | AKNA | S1160 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q8IY57 | YAF2 | S112 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8IYB7 | DIS3L2 | S139 | ochoa | DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}. |
| Q8IYI6 | EXOC8 | S151 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8IZ21 | PHACTR4 | S118 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8IZT6 | ASPM | S577 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N6F7 | GCSAM | S120 | ochoa | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| Q8ND56 | LSM14A | S227 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDI1 | EHBP1 | S854 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NEB9 | PIK3C3 | S164 | psp | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NEL9 | DDHD1 | S240 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8NFT2 | STEAP2 | S197 | ochoa | Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). {ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8BWB6}. |
| Q8NHV4 | NEDD1 | S468 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TDF6 | RASGRP4 | S515 | ochoa | RAS guanyl-releasing protein 4 | Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity). {ECO:0000250|UniProtKB:Q8BTM9, ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}. |
| Q8WWK9 | CKAP2 | S357 | ochoa | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q8WXG6 | MADD | S230 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q92547 | TOPBP1 | S864 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92576 | PHF3 | S1148 | ochoa | PHD finger protein 3 | None |
| Q92854 | SEMA4D | S800 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q96AY2 | EME1 | S85 | ochoa | Structure-specific endonuclease subunit EME1 (Crossover junction endonuclease EME1) (Essential meiotic structure-specific endonuclease 1) (MMS4 homolog) (hMMS4) | Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME1 which is involved in the maintenance of genome stability. In the complex, EME1 is required for DNA cleavage, participating in DNA recognition and bending (PubMed:12686547, PubMed:12721304, PubMed:14617801, PubMed:17289582, PubMed:24733841, PubMed:24813886, PubMed:35290797, PubMed:39015284). MUS81-EME1 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs (PubMed:24733841, PubMed:35290797). Active during prometaphase, MUS81-EME1 resolves mitotic recombination intermediates, including Holliday junctions, which form during homologous recombination (PubMed:14617801, PubMed:24813886). {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:24733841, ECO:0000269|PubMed:24813886, ECO:0000269|PubMed:35290797, ECO:0000269|PubMed:39015284}. |
| Q96D71 | REPS1 | S751 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96PE3 | INPP4A | S487 | ochoa | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}. |
| Q96Q15 | SMG1 | S3556 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96Q89 | KIF20B | S1592 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96RG2 | PASK | S1277 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RS0 | TGS1 | S578 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96S38 | RPS6KC1 | S427 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96S38 | RPS6KC1 | S644 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96SD1 | DCLRE1C | S455 | ochoa | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. |
| Q99666 | RGPD5 | S1592 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99959 | PKP2 | S53 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQE3 | TUBA1C | S277 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BRQ6 | CHCHD6 | S126 | ochoa | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}. |
| Q9BUR4 | WRAP53 | S491 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BY89 | KIAA1671 | S518 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYM8 | RBCK1 | S229 | ochoa | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9BYM8 | RBCK1 | S333 | ochoa | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9BZ95 | NSD3 | S568 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZ95 | NSD3 | S913 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9C0C7 | AMBRA1 | S637 | ochoa | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
| Q9H0H5 | RACGAP1 | S114 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H6X5 | C19orf44 | S240 | ochoa | Uncharacterized protein C19orf44 | None |
| Q9H777 | ELAC1 | S146 | ochoa | Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1) | Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity (PubMed:12711671, PubMed:32075755). Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1 (PubMed:32075755). tRNAs are then processed by TRNT1 (PubMed:32075755). {ECO:0000269|PubMed:12711671, ECO:0000269|PubMed:32075755}. |
| Q9NPG3 | UBN1 | S142 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NRL2 | BAZ1A | S1320 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NZ52 | GGA3 | S388 | ochoa | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
| Q9NZN5 | ARHGEF12 | S751 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9NZT2 | OGFR | S403 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P265 | DIP2B | S100 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P265 | DIP2B | S146 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P2E9 | RRBP1 | S659 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UBL0 | ARPP21 | S31 | ochoa | cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) | Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}. |
| Q9UBS5 | GABBR1 | S879 | ochoa | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:36103875, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:24305054, PubMed:9872744). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9844003, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:24305054, PubMed:9844003, PubMed:9872316). {ECO:0000250|UniProtKB:Q9Z0U4, ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10773016, ECO:0000269|PubMed:10906333, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:36103875, ECO:0000269|PubMed:9844003, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}.; FUNCTION: Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. |
| Q9UHB6 | LIMA1 | S619 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHY8 | FEZ2 | S205 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UJ70 | NAGK | S76 | ochoa | N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}. |
| Q9UKX7 | NUP50 | S204 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9UKY1 | ZHX1 | S591 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9ULH7 | MRTFB | S395 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9UNE7 | STUB1 | S273 | ochoa | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}. |
| Q9UNY4 | TTF2 | S251 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPU5 | USP24 | S117 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPZ3 | HPS5 | S1058 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9UQ35 | SRRM2 | S1311 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2E4 | DIP2C | S89 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y2I9 | TBC1D30 | S713 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
| Q9Y2J4 | AMOTL2 | S549 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2K6 | USP20 | S341 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y3R5 | DOP1B | S1191 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y520 | PRRC2C | S893 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y566 | SHANK1 | S890 | ochoa | SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| P35613 | BSG | S279 | Sugiyama | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| P52789 | HK2 | S889 | Sugiyama | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| Q8WVM8 | SCFD1 | S347 | Sugiyama | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| O43172 | PRPF4 | Y32 | Sugiyama | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O15355 | PPM1G | S363 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| Q99497 | PARK7 | S142 | Sugiyama | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) | Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}. |
| O00541 | PES1 | Y265 | Sugiyama | Pescadillo homolog | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}. |
| P07332 | FES | S485 | Sugiyama | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| P29401 | TKT | S449 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P41279 | MAP3K8 | S358 | Sugiyama | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}. |
| P51957 | NEK4 | S402 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| O75128 | COBL | S1171 | Sugiyama | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| P52888 | THOP1 | S29 | Sugiyama | Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}. |
| P35613 | BSG | S229 | Sugiyama | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| Q16816 | PHKG1 | S58 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q14694 | USP10 | S253 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q86UP2 | KTN1 | S1181 | Sugiyama | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q9UNW1 | MINPP1 | S468 | Sugiyama | Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) | Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:33257696, PubMed:36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed:36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed:18413611). {ECO:0000269|PubMed:18413611, ECO:0000269|PubMed:33257696, ECO:0000269|PubMed:36589890}. |
| Q6XUX3 | DSTYK | S292 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| O75179 | ANKRD17 | S1159 | Sugiyama | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| Q8IWZ3 | ANKHD1 | S1131 | Sugiyama | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8TEW0 | PARD3 | S736 | Sugiyama | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q14524 | SCN5A | S1885 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.811806e-11 | 10.419 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.700313e-10 | 9.769 |
| R-HSA-68877 | Mitotic Prometaphase | 1.362664e-09 | 8.866 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.167580e-09 | 8.038 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.354061e-08 | 7.868 |
| R-HSA-983189 | Kinesins | 1.536844e-08 | 7.813 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.829569e-08 | 7.738 |
| R-HSA-68886 | M Phase | 2.790814e-08 | 7.554 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.213546e-08 | 7.493 |
| R-HSA-1640170 | Cell Cycle | 7.790083e-08 | 7.108 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.094306e-07 | 6.961 |
| R-HSA-9646399 | Aggrephagy | 1.454759e-07 | 6.837 |
| R-HSA-70171 | Glycolysis | 1.522985e-07 | 6.817 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.447469e-07 | 6.839 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.523248e-07 | 6.598 |
| R-HSA-68882 | Mitotic Anaphase | 2.561698e-07 | 6.591 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.392337e-07 | 6.621 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.436579e-07 | 6.613 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.700915e-07 | 6.568 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.423472e-07 | 6.354 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 6.265686e-07 | 6.203 |
| R-HSA-70326 | Glucose metabolism | 7.645551e-07 | 6.117 |
| R-HSA-190861 | Gap junction assembly | 8.713058e-07 | 6.060 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.529163e-07 | 6.021 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.286238e-06 | 5.891 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.450419e-06 | 5.611 |
| R-HSA-9609690 | HCMV Early Events | 2.823465e-06 | 5.549 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.797351e-06 | 5.553 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.557964e-06 | 5.449 |
| R-HSA-190828 | Gap junction trafficking | 4.113067e-06 | 5.386 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.048468e-06 | 5.297 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 5.908187e-06 | 5.229 |
| R-HSA-437239 | Recycling pathway of L1 | 5.908187e-06 | 5.229 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 6.786861e-06 | 5.168 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.672758e-06 | 5.176 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.759497e-06 | 5.110 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.984776e-06 | 5.098 |
| R-HSA-157858 | Gap junction trafficking and regulation | 7.434028e-06 | 5.129 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.260578e-06 | 5.083 |
| R-HSA-69275 | G2/M Transition | 9.450747e-06 | 5.025 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.039877e-05 | 4.983 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.442402e-05 | 4.841 |
| R-HSA-9833482 | PKR-mediated signaling | 1.442402e-05 | 4.841 |
| R-HSA-191859 | snRNP Assembly | 2.082485e-05 | 4.681 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.082485e-05 | 4.681 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.143339e-05 | 4.669 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.299101e-05 | 4.638 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.299101e-05 | 4.638 |
| R-HSA-199991 | Membrane Trafficking | 2.409015e-05 | 4.618 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.665704e-05 | 4.574 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.727291e-05 | 4.564 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.745005e-05 | 4.561 |
| R-HSA-1632852 | Macroautophagy | 2.765127e-05 | 4.558 |
| R-HSA-9609646 | HCMV Infection | 3.065752e-05 | 4.513 |
| R-HSA-9663891 | Selective autophagy | 2.866620e-05 | 4.543 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.181168e-05 | 4.497 |
| R-HSA-373760 | L1CAM interactions | 3.530024e-05 | 4.452 |
| R-HSA-391251 | Protein folding | 4.071693e-05 | 4.390 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.121077e-05 | 4.385 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.282062e-05 | 4.277 |
| R-HSA-5617833 | Cilium Assembly | 5.779161e-05 | 4.238 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.850338e-05 | 4.233 |
| R-HSA-9612973 | Autophagy | 6.145981e-05 | 4.211 |
| R-HSA-5620924 | Intraflagellar transport | 7.133276e-05 | 4.147 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.304415e-05 | 4.136 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.708582e-05 | 4.060 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 8.758887e-05 | 4.058 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.426296e-05 | 4.026 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.947459e-05 | 4.002 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.947459e-05 | 4.002 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.269299e-04 | 3.896 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.269299e-04 | 3.896 |
| R-HSA-913531 | Interferon Signaling | 1.394083e-04 | 3.856 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.426630e-04 | 3.846 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.426630e-04 | 3.846 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.551331e-04 | 3.809 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.785672e-04 | 3.748 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.598461e-04 | 3.796 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.925610e-04 | 3.715 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.209871e-04 | 3.656 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.706732e-04 | 3.568 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.706732e-04 | 3.568 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.951007e-04 | 3.530 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.984856e-04 | 3.525 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.984856e-04 | 3.525 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.284122e-04 | 3.484 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.775993e-04 | 3.321 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.013293e-04 | 3.300 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.079089e-04 | 3.294 |
| R-HSA-422475 | Axon guidance | 5.876917e-04 | 3.231 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.567891e-04 | 3.183 |
| R-HSA-428540 | Activation of RAC1 | 8.605631e-04 | 3.065 |
| R-HSA-9675108 | Nervous system development | 1.168987e-03 | 2.932 |
| R-HSA-75893 | TNF signaling | 1.185034e-03 | 2.926 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.257487e-03 | 2.900 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.268224e-03 | 2.897 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.644672e-03 | 2.784 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.750363e-03 | 2.757 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.159041e-03 | 2.666 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.507980e-03 | 2.601 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.737140e-03 | 2.563 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.143161e-03 | 2.503 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.265774e-03 | 2.486 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.439130e-03 | 2.464 |
| R-HSA-211000 | Gene Silencing by RNA | 3.519254e-03 | 2.454 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.616680e-03 | 2.442 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.619007e-03 | 2.441 |
| R-HSA-373753 | Nephrin family interactions | 3.646931e-03 | 2.438 |
| R-HSA-2262752 | Cellular responses to stress | 3.923160e-03 | 2.406 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.446955e-03 | 2.352 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.629149e-03 | 2.334 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 5.500236e-03 | 2.260 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.072038e-03 | 2.295 |
| R-HSA-5693538 | Homology Directed Repair | 5.769497e-03 | 2.239 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.553529e-03 | 2.255 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 5.500236e-03 | 2.260 |
| R-HSA-1280218 | Adaptive Immune System | 5.383849e-03 | 2.269 |
| R-HSA-162587 | HIV Life Cycle | 5.830743e-03 | 2.234 |
| R-HSA-68875 | Mitotic Prophase | 6.191602e-03 | 2.208 |
| R-HSA-3371556 | Cellular response to heat stress | 6.410889e-03 | 2.193 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.102648e-03 | 2.149 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.492985e-03 | 2.125 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.791004e-03 | 2.108 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 8.087386e-03 | 2.092 |
| R-HSA-162582 | Signal Transduction | 8.209799e-03 | 2.086 |
| R-HSA-72306 | tRNA processing | 8.692999e-03 | 2.061 |
| R-HSA-186763 | Downstream signal transduction | 1.063968e-02 | 1.973 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.130930e-02 | 1.947 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.135265e-02 | 1.945 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.135265e-02 | 1.945 |
| R-HSA-373755 | Semaphorin interactions | 1.135265e-02 | 1.945 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.207656e-02 | 1.918 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.224387e-02 | 1.912 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.279363e-02 | 1.893 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.303065e-02 | 1.885 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.309511e-02 | 1.883 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.362321e-02 | 1.866 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.391540e-02 | 1.857 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.753808e-02 | 1.756 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.457132e-02 | 1.837 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.459509e-02 | 1.836 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.842389e-02 | 1.735 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.890067e-02 | 1.724 |
| R-HSA-380287 | Centrosome maturation | 1.898325e-02 | 1.722 |
| R-HSA-73887 | Death Receptor Signaling | 1.910859e-02 | 1.719 |
| R-HSA-202433 | Generation of second messenger molecules | 1.998563e-02 | 1.699 |
| R-HSA-9610379 | HCMV Late Events | 2.058878e-02 | 1.686 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.110431e-02 | 1.676 |
| R-HSA-1500931 | Cell-Cell communication | 2.217795e-02 | 1.654 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.265538e-02 | 1.645 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.265538e-02 | 1.645 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.265538e-02 | 1.645 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.375248e-02 | 1.624 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.392963e-02 | 1.621 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.392963e-02 | 1.621 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.466273e-02 | 1.608 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.591631e-02 | 1.586 |
| R-HSA-5619102 | SLC transporter disorders | 2.608066e-02 | 1.584 |
| R-HSA-69481 | G2/M Checkpoints | 3.021675e-02 | 1.520 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.031734e-02 | 1.518 |
| R-HSA-70263 | Gluconeogenesis | 3.126665e-02 | 1.505 |
| R-HSA-162906 | HIV Infection | 3.190362e-02 | 1.496 |
| R-HSA-3928664 | Ephrin signaling | 3.217529e-02 | 1.492 |
| R-HSA-597592 | Post-translational protein modification | 3.268295e-02 | 1.486 |
| R-HSA-168255 | Influenza Infection | 3.456984e-02 | 1.461 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.567993e-02 | 1.448 |
| R-HSA-9635644 | Inhibition of membrane repair | 3.567993e-02 | 1.448 |
| R-HSA-109582 | Hemostasis | 3.651512e-02 | 1.438 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.870412e-02 | 1.312 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 4.728950e-02 | 1.325 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.742559e-02 | 1.427 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 4.881688e-02 | 1.311 |
| R-HSA-73894 | DNA Repair | 4.313432e-02 | 1.365 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.586312e-02 | 1.339 |
| R-HSA-3000170 | Syndecan interactions | 4.881688e-02 | 1.311 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.330678e-02 | 1.363 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.742559e-02 | 1.427 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.297857e-02 | 1.367 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.412821e-02 | 1.355 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 5.183780e-02 | 1.285 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.224936e-02 | 1.282 |
| R-HSA-186797 | Signaling by PDGF | 5.413239e-02 | 1.267 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.492385e-02 | 1.260 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 5.492385e-02 | 1.260 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.600374e-02 | 1.252 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.877496e-02 | 1.231 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.060935e-02 | 1.217 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 6.128342e-02 | 1.213 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 6.128342e-02 | 1.213 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.128342e-02 | 1.213 |
| R-HSA-202403 | TCR signaling | 6.212261e-02 | 1.207 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.379201e-02 | 1.195 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.788014e-02 | 1.168 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.131336e-02 | 1.147 |
| R-HSA-182971 | EGFR downregulation | 7.469915e-02 | 1.127 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 8.076416e-02 | 1.093 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.235362e-02 | 1.035 |
| R-HSA-1855231 | Synthesis of IPs in the ER lumen | 1.032843e-01 | 0.986 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 1.032843e-01 | 0.986 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 1.140839e-01 | 0.943 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.247542e-01 | 0.904 |
| R-HSA-8875656 | MET receptor recycling | 1.247542e-01 | 0.904 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 1.352966e-01 | 0.869 |
| R-HSA-164843 | 2-LTR circle formation | 1.457126e-01 | 0.837 |
| R-HSA-68952 | DNA replication initiation | 1.457126e-01 | 0.837 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.661717e-01 | 0.779 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.661717e-01 | 0.779 |
| R-HSA-69091 | Polymerase switching | 1.762177e-01 | 0.754 |
| R-HSA-69109 | Leading Strand Synthesis | 1.762177e-01 | 0.754 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.861433e-01 | 0.730 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.959499e-01 | 0.708 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.959499e-01 | 0.708 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.056389e-01 | 0.687 |
| R-HSA-390522 | Striated Muscle Contraction | 8.531336e-02 | 1.069 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.246699e-01 | 0.648 |
| R-HSA-774815 | Nucleosome assembly | 1.356501e-01 | 0.868 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.356501e-01 | 0.868 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.564360e-01 | 0.806 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.056389e-01 | 0.687 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 8.894744e-02 | 1.051 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.056389e-01 | 0.687 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.606638e-01 | 0.794 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.140839e-01 | 0.943 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1.247542e-01 | 0.904 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.457126e-01 | 0.837 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 8.172617e-02 | 1.088 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.246699e-01 | 0.648 |
| R-HSA-9710421 | Defective pyroptosis | 1.275231e-01 | 0.894 |
| R-HSA-1221632 | Meiotic synapsis | 1.691809e-01 | 0.772 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.329736e-01 | 0.876 |
| R-HSA-73886 | Chromosome Maintenance | 8.286315e-02 | 1.082 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.032843e-01 | 0.986 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.457126e-01 | 0.837 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.762177e-01 | 0.754 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.056389e-01 | 0.687 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.056389e-01 | 0.687 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.056389e-01 | 0.687 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.152118e-01 | 0.667 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8.894744e-02 | 1.051 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.432472e-01 | 0.614 |
| R-HSA-157579 | Telomere Maintenance | 1.441540e-01 | 0.841 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.438007e-01 | 0.613 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.260049e-01 | 0.646 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.352966e-01 | 0.869 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.861433e-01 | 0.730 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.959499e-01 | 0.708 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.039205e-01 | 0.983 |
| R-HSA-912446 | Meiotic recombination | 1.606638e-01 | 0.794 |
| R-HSA-180786 | Extension of Telomeres | 1.951471e-01 | 0.710 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.438007e-01 | 0.613 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.560039e-01 | 0.807 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.661717e-01 | 0.779 |
| R-HSA-450294 | MAP kinase activation | 2.039140e-01 | 0.691 |
| R-HSA-71336 | Pentose phosphate pathway | 1.077651e-01 | 0.968 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.438890e-01 | 0.842 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.352966e-01 | 0.869 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 9.262678e-02 | 1.033 |
| R-HSA-448424 | Interleukin-17 signaling | 2.438007e-01 | 0.613 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.789795e-01 | 0.747 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.316126e-01 | 0.635 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.555014e-01 | 0.808 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.140839e-01 | 0.943 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.762177e-01 | 0.754 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.469644e-01 | 0.833 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.469644e-01 | 0.833 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.469644e-01 | 0.833 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.849955e-01 | 0.733 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.849955e-01 | 0.733 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.700609e-01 | 0.769 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.819807e-01 | 0.740 |
| R-HSA-8953854 | Metabolism of RNA | 9.797191e-02 | 1.009 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.189554e-01 | 0.660 |
| R-HSA-416700 | Other semaphorin interactions | 2.056389e-01 | 0.687 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 2.246699e-01 | 0.648 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.189554e-01 | 0.660 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.284352e-01 | 0.641 |
| R-HSA-162592 | Integration of provirus | 1.661717e-01 | 0.779 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.284352e-01 | 0.641 |
| R-HSA-9675135 | Diseases of DNA repair | 1.397562e-01 | 0.855 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 8.129044e-02 | 1.090 |
| R-HSA-448706 | Interleukin-1 processing | 1.352966e-01 | 0.869 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.560039e-01 | 0.807 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.959499e-01 | 0.708 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.056389e-01 | 0.687 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.941178e-01 | 0.712 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.432472e-01 | 0.614 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.758353e-02 | 1.058 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.550555e-02 | 1.068 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.861433e-01 | 0.730 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.083141e-01 | 0.681 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.064500e-01 | 0.685 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.999692e-01 | 0.699 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.480474e-01 | 0.830 |
| R-HSA-194138 | Signaling by VEGF | 2.411926e-01 | 0.618 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.340146e-01 | 0.631 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.348928e-01 | 0.629 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.126824e-01 | 0.672 |
| R-HSA-2028269 | Signaling by Hippo | 2.340146e-01 | 0.631 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 1.356501e-01 | 0.868 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.340055e-01 | 0.873 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.043916e-01 | 0.981 |
| R-HSA-177929 | Signaling by EGFR | 1.820939e-01 | 0.740 |
| R-HSA-9707616 | Heme signaling | 2.083141e-01 | 0.681 |
| R-HSA-1266738 | Developmental Biology | 2.083338e-01 | 0.681 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 8.172617e-02 | 1.088 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.171431e-01 | 0.663 |
| R-HSA-5688426 | Deubiquitination | 1.190112e-01 | 0.924 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 8.990922e-02 | 1.046 |
| R-HSA-392499 | Metabolism of proteins | 2.052404e-01 | 0.688 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.595986e-01 | 0.797 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.710568e-01 | 0.767 |
| R-HSA-446728 | Cell junction organization | 1.552680e-01 | 0.809 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.438007e-01 | 0.613 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.432472e-01 | 0.614 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.275231e-01 | 0.894 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.410607e-01 | 0.618 |
| R-HSA-6806834 | Signaling by MET | 9.226063e-02 | 1.035 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.246699e-01 | 0.648 |
| R-HSA-9824446 | Viral Infection Pathways | 1.038111e-01 | 0.984 |
| R-HSA-112316 | Neuronal System | 1.415288e-01 | 0.849 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.163202e-02 | 1.088 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.432472e-01 | 0.614 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.215703e-01 | 0.654 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 1.075126e-01 | 0.969 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.482601e-01 | 0.605 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.510027e-01 | 0.600 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.523691e-01 | 0.598 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.523691e-01 | 0.598 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.523691e-01 | 0.598 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.523691e-01 | 0.598 |
| R-HSA-5663205 | Infectious disease | 2.542849e-01 | 0.595 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.613816e-01 | 0.583 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.613816e-01 | 0.583 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.613816e-01 | 0.583 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.613816e-01 | 0.583 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.613816e-01 | 0.583 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.613816e-01 | 0.583 |
| R-HSA-9679506 | SARS-CoV Infections | 2.652066e-01 | 0.576 |
| R-HSA-210991 | Basigin interactions | 2.702860e-01 | 0.568 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.702860e-01 | 0.568 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.702860e-01 | 0.568 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.702860e-01 | 0.568 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.702860e-01 | 0.568 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 2.702860e-01 | 0.568 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.702860e-01 | 0.568 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.705847e-01 | 0.568 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.750503e-01 | 0.561 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.790836e-01 | 0.554 |
| R-HSA-216083 | Integrin cell surface interactions | 2.795147e-01 | 0.554 |
| R-HSA-163685 | Integration of energy metabolism | 2.833530e-01 | 0.548 |
| R-HSA-9659379 | Sensory processing of sound | 2.839772e-01 | 0.547 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.877757e-01 | 0.541 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.877757e-01 | 0.541 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.877757e-01 | 0.541 |
| R-HSA-977225 | Amyloid fiber formation | 2.928941e-01 | 0.533 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.963635e-01 | 0.528 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.048483e-01 | 0.516 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.048483e-01 | 0.516 |
| R-HSA-429947 | Deadenylation of mRNA | 3.048483e-01 | 0.516 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.048483e-01 | 0.516 |
| R-HSA-397014 | Muscle contraction | 3.098446e-01 | 0.509 |
| R-HSA-1500620 | Meiosis | 3.106800e-01 | 0.508 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.106800e-01 | 0.508 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.125598e-01 | 0.505 |
| R-HSA-1296059 | G protein gated Potassium channels | 3.132313e-01 | 0.504 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 3.132313e-01 | 0.504 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 3.132313e-01 | 0.504 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.132313e-01 | 0.504 |
| R-HSA-420029 | Tight junction interactions | 3.132313e-01 | 0.504 |
| R-HSA-3214842 | HDMs demethylate histones | 3.132313e-01 | 0.504 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.132313e-01 | 0.504 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.132313e-01 | 0.504 |
| R-HSA-3000157 | Laminin interactions | 3.132313e-01 | 0.504 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.151133e-01 | 0.502 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.195404e-01 | 0.495 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.203802e-01 | 0.494 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.215137e-01 | 0.493 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.215137e-01 | 0.493 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.215137e-01 | 0.493 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.215137e-01 | 0.493 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.215137e-01 | 0.493 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.215137e-01 | 0.493 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.239607e-01 | 0.490 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.260921e-01 | 0.487 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.283737e-01 | 0.484 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.296967e-01 | 0.482 |
| R-HSA-8949613 | Cristae formation | 3.296967e-01 | 0.482 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.296967e-01 | 0.482 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.296967e-01 | 0.482 |
| R-HSA-264876 | Insulin processing | 3.296967e-01 | 0.482 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.296967e-01 | 0.482 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.359752e-01 | 0.474 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.369902e-01 | 0.472 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.377816e-01 | 0.471 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.377816e-01 | 0.471 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 3.377816e-01 | 0.471 |
| R-HSA-622312 | Inflammasomes | 3.377816e-01 | 0.471 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.392684e-01 | 0.469 |
| R-HSA-5334118 | DNA methylation | 3.457694e-01 | 0.461 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.457694e-01 | 0.461 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.457694e-01 | 0.461 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.457694e-01 | 0.461 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.503144e-01 | 0.456 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.536613e-01 | 0.451 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.536613e-01 | 0.451 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.536613e-01 | 0.451 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.590002e-01 | 0.445 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 3.614586e-01 | 0.442 |
| R-HSA-168256 | Immune System | 3.685317e-01 | 0.434 |
| R-HSA-69190 | DNA strand elongation | 3.691622e-01 | 0.433 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.691622e-01 | 0.433 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.691622e-01 | 0.433 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.720093e-01 | 0.429 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.767734e-01 | 0.424 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.767734e-01 | 0.424 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.767734e-01 | 0.424 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.767734e-01 | 0.424 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.842932e-01 | 0.415 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.842932e-01 | 0.415 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.917227e-01 | 0.407 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.917227e-01 | 0.407 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.917227e-01 | 0.407 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.917227e-01 | 0.407 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.917227e-01 | 0.407 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.917227e-01 | 0.407 |
| R-HSA-1483255 | PI Metabolism | 3.976533e-01 | 0.400 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.063153e-01 | 0.391 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.063153e-01 | 0.391 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.063153e-01 | 0.391 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.134804e-01 | 0.384 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.134804e-01 | 0.384 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.134804e-01 | 0.384 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 4.205595e-01 | 0.376 |
| R-HSA-73927 | Depurination | 4.205595e-01 | 0.376 |
| R-HSA-1566948 | Elastic fibre formation | 4.205595e-01 | 0.376 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.205595e-01 | 0.376 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.228072e-01 | 0.374 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.228072e-01 | 0.374 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.275536e-01 | 0.369 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.275536e-01 | 0.369 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.275536e-01 | 0.369 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.296218e-01 | 0.367 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.310727e-01 | 0.365 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.344637e-01 | 0.362 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.344637e-01 | 0.362 |
| R-HSA-5260271 | Diseases of Immune System | 4.344637e-01 | 0.362 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.344637e-01 | 0.362 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 4.344637e-01 | 0.362 |
| R-HSA-8982491 | Glycogen metabolism | 4.344637e-01 | 0.362 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.412908e-01 | 0.355 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.412908e-01 | 0.355 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.412908e-01 | 0.355 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.412908e-01 | 0.355 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.412908e-01 | 0.355 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.412908e-01 | 0.355 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.480359e-01 | 0.349 |
| R-HSA-977444 | GABA B receptor activation | 4.547000e-01 | 0.342 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.547000e-01 | 0.342 |
| R-HSA-991365 | Activation of GABAB receptors | 4.547000e-01 | 0.342 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.547000e-01 | 0.342 |
| R-HSA-73928 | Depyrimidination | 4.547000e-01 | 0.342 |
| R-HSA-165159 | MTOR signalling | 4.547000e-01 | 0.342 |
| R-HSA-8854214 | TBC/RABGAPs | 4.612840e-01 | 0.336 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.612840e-01 | 0.336 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.616279e-01 | 0.336 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.634904e-01 | 0.334 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.677890e-01 | 0.330 |
| R-HSA-373752 | Netrin-1 signaling | 4.677890e-01 | 0.330 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.714260e-01 | 0.327 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.733193e-01 | 0.325 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.742158e-01 | 0.324 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.773424e-01 | 0.321 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.805654e-01 | 0.318 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.805654e-01 | 0.318 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.805654e-01 | 0.318 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.805654e-01 | 0.318 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.870849e-01 | 0.312 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.870849e-01 | 0.312 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.986390e-01 | 0.302 |
| R-HSA-9766229 | Degradation of CDH1 | 4.991600e-01 | 0.302 |
| R-HSA-73893 | DNA Damage Bypass | 4.991600e-01 | 0.302 |
| R-HSA-109704 | PI3K Cascade | 5.052098e-01 | 0.297 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 5.052098e-01 | 0.297 |
| R-HSA-69206 | G1/S Transition | 5.062494e-01 | 0.296 |
| R-HSA-72172 | mRNA Splicing | 5.106606e-01 | 0.292 |
| R-HSA-114608 | Platelet degranulation | 5.137848e-01 | 0.289 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.170923e-01 | 0.286 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.170923e-01 | 0.286 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.170923e-01 | 0.286 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.170923e-01 | 0.286 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.229266e-01 | 0.282 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.229266e-01 | 0.282 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.229266e-01 | 0.282 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.229266e-01 | 0.282 |
| R-HSA-1474165 | Reproduction | 5.286279e-01 | 0.277 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.286908e-01 | 0.277 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.286908e-01 | 0.277 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 5.322907e-01 | 0.274 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.343857e-01 | 0.272 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.343857e-01 | 0.272 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.395582e-01 | 0.268 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.400121e-01 | 0.268 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.400121e-01 | 0.268 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.400121e-01 | 0.268 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.424346e-01 | 0.266 |
| R-HSA-112399 | IRS-mediated signalling | 5.455709e-01 | 0.263 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.455709e-01 | 0.263 |
| R-HSA-1483166 | Synthesis of PA | 5.455709e-01 | 0.263 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.455709e-01 | 0.263 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.510628e-01 | 0.259 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.510628e-01 | 0.259 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.564887e-01 | 0.255 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.564887e-01 | 0.255 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.618494e-01 | 0.250 |
| R-HSA-977443 | GABA receptor activation | 5.618494e-01 | 0.250 |
| R-HSA-379724 | tRNA Aminoacylation | 5.618494e-01 | 0.250 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.618494e-01 | 0.250 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.618494e-01 | 0.250 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.671456e-01 | 0.246 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.671456e-01 | 0.246 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.671456e-01 | 0.246 |
| R-HSA-1643685 | Disease | 5.711422e-01 | 0.243 |
| R-HSA-1268020 | Mitochondrial protein import | 5.723781e-01 | 0.242 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.723781e-01 | 0.242 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.723781e-01 | 0.242 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.723781e-01 | 0.242 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.723781e-01 | 0.242 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.826551e-01 | 0.235 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.826551e-01 | 0.235 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.848822e-01 | 0.233 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.877010e-01 | 0.231 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.877010e-01 | 0.231 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.915576e-01 | 0.228 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.926863e-01 | 0.227 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.954492e-01 | 0.225 |
| R-HSA-69242 | S Phase | 5.981532e-01 | 0.223 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.024776e-01 | 0.220 |
| R-HSA-5218859 | Regulated Necrosis | 6.024776e-01 | 0.220 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.046690e-01 | 0.218 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.120348e-01 | 0.213 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.120348e-01 | 0.213 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.120348e-01 | 0.213 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.120348e-01 | 0.213 |
| R-HSA-69306 | DNA Replication | 6.142931e-01 | 0.212 |
| R-HSA-9609507 | Protein localization | 6.142931e-01 | 0.212 |
| R-HSA-1474244 | Extracellular matrix organization | 6.163871e-01 | 0.210 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.167272e-01 | 0.210 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.167272e-01 | 0.210 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.167272e-01 | 0.210 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.167272e-01 | 0.210 |
| R-HSA-3000178 | ECM proteoglycans | 6.167272e-01 | 0.210 |
| R-HSA-9638482 | Metal ion assimilation from the host | 6.167272e-01 | 0.210 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.213633e-01 | 0.207 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.213633e-01 | 0.207 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.213633e-01 | 0.207 |
| R-HSA-4086398 | Ca2+ pathway | 6.259435e-01 | 0.203 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.259435e-01 | 0.203 |
| R-HSA-9749641 | Aspirin ADME | 6.259435e-01 | 0.203 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 6.268466e-01 | 0.203 |
| R-HSA-877300 | Interferon gamma signaling | 6.330042e-01 | 0.199 |
| R-HSA-4839726 | Chromatin organization | 6.341236e-01 | 0.198 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.360533e-01 | 0.197 |
| R-HSA-421270 | Cell-cell junction organization | 6.390830e-01 | 0.194 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.393561e-01 | 0.194 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.480308e-01 | 0.188 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.480308e-01 | 0.188 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 6.480308e-01 | 0.188 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.564980e-01 | 0.183 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.606553e-01 | 0.180 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.647625e-01 | 0.177 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.688203e-01 | 0.175 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.688203e-01 | 0.175 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.728292e-01 | 0.172 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.739072e-01 | 0.171 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.766832e-01 | 0.170 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.766832e-01 | 0.170 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.767898e-01 | 0.170 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.836152e-01 | 0.165 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.845685e-01 | 0.165 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 6.921609e-01 | 0.160 |
| R-HSA-2559583 | Cellular Senescence | 6.955827e-01 | 0.158 |
| R-HSA-202424 | Downstream TCR signaling | 6.995714e-01 | 0.155 |
| R-HSA-73884 | Base Excision Repair | 6.995714e-01 | 0.155 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.032099e-01 | 0.153 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.033045e-01 | 0.153 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.034003e-01 | 0.153 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.099376e-01 | 0.149 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.103558e-01 | 0.149 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.138643e-01 | 0.146 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.138643e-01 | 0.146 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.173306e-01 | 0.144 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.173306e-01 | 0.144 |
| R-HSA-1474290 | Collagen formation | 7.173306e-01 | 0.144 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.207550e-01 | 0.142 |
| R-HSA-1296071 | Potassium Channels | 7.274806e-01 | 0.138 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.274806e-01 | 0.138 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.340449e-01 | 0.134 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.353516e-01 | 0.134 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.353745e-01 | 0.133 |
| R-HSA-1483257 | Phospholipid metabolism | 7.363103e-01 | 0.133 |
| R-HSA-3214847 | HATs acetylate histones | 7.372679e-01 | 0.132 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.372679e-01 | 0.132 |
| R-HSA-195721 | Signaling by WNT | 7.421219e-01 | 0.130 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.435977e-01 | 0.129 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.446077e-01 | 0.128 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.467055e-01 | 0.127 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.467055e-01 | 0.127 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.513512e-01 | 0.124 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.558057e-01 | 0.122 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.558057e-01 | 0.122 |
| R-HSA-6805567 | Keratinization | 7.601050e-01 | 0.119 |
| R-HSA-69239 | Synthesis of DNA | 7.645806e-01 | 0.117 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.674353e-01 | 0.115 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.674353e-01 | 0.115 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.785138e-01 | 0.109 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.785138e-01 | 0.109 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.812003e-01 | 0.107 |
| R-HSA-418990 | Adherens junctions interactions | 7.847893e-01 | 0.105 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.864766e-01 | 0.104 |
| R-HSA-8957322 | Metabolism of steroids | 7.883232e-01 | 0.103 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.966523e-01 | 0.099 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.991200e-01 | 0.097 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.999867e-01 | 0.097 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.015578e-01 | 0.096 |
| R-HSA-72312 | rRNA processing | 8.107561e-01 | 0.091 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.110183e-01 | 0.091 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.178180e-01 | 0.087 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.178180e-01 | 0.087 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.178180e-01 | 0.087 |
| R-HSA-8939211 | ESR-mediated signaling | 8.193346e-01 | 0.087 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.286140e-01 | 0.082 |
| R-HSA-9843745 | Adipogenesis | 8.327521e-01 | 0.079 |
| R-HSA-5576891 | Cardiac conduction | 8.327521e-01 | 0.079 |
| R-HSA-9909396 | Circadian clock | 8.347836e-01 | 0.078 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.347836e-01 | 0.078 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.445791e-01 | 0.073 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.445791e-01 | 0.073 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.464677e-01 | 0.072 |
| R-HSA-6807070 | PTEN Regulation | 8.501767e-01 | 0.070 |
| R-HSA-9664407 | Parasite infection | 8.519977e-01 | 0.070 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.519977e-01 | 0.070 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.519977e-01 | 0.070 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.537966e-01 | 0.069 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.706315e-01 | 0.060 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.727148e-01 | 0.059 |
| R-HSA-2142753 | Arachidonate metabolism | 8.737595e-01 | 0.059 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.768122e-01 | 0.057 |
| R-HSA-1989781 | PPARA activates gene expression | 8.783109e-01 | 0.056 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.810257e-01 | 0.055 |
| R-HSA-9658195 | Leishmania infection | 8.810257e-01 | 0.055 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.812541e-01 | 0.055 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.910086e-01 | 0.050 |
| R-HSA-74160 | Gene expression (Transcription) | 8.914520e-01 | 0.050 |
| R-HSA-449147 | Signaling by Interleukins | 8.945953e-01 | 0.048 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.961691e-01 | 0.048 |
| R-HSA-168249 | Innate Immune System | 8.995118e-01 | 0.046 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.999656e-01 | 0.046 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.047510e-01 | 0.043 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.059113e-01 | 0.043 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.197755e-01 | 0.036 |
| R-HSA-6798695 | Neutrophil degranulation | 9.307843e-01 | 0.031 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.332647e-01 | 0.030 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.332647e-01 | 0.030 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.348953e-01 | 0.029 |
| R-HSA-5357801 | Programmed Cell Death | 9.356785e-01 | 0.029 |
| R-HSA-9748784 | Drug ADME | 9.451735e-01 | 0.024 |
| R-HSA-8951664 | Neddylation | 9.471585e-01 | 0.024 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.526947e-01 | 0.021 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.565982e-01 | 0.019 |
| R-HSA-157118 | Signaling by NOTCH | 9.581715e-01 | 0.019 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.605312e-01 | 0.017 |
| R-HSA-8978868 | Fatty acid metabolism | 9.669123e-01 | 0.015 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.684907e-01 | 0.014 |
| R-HSA-212436 | Generic Transcription Pathway | 9.723010e-01 | 0.012 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.849811e-01 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.909628e-01 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.940754e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.947682e-01 | 0.002 |
| R-HSA-72766 | Translation | 9.960216e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.994263e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.994379e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.994635e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.996277e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.997813e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999682e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999964e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999977e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.877 | 0.161 | 2 | 0.883 |
CLK3 |
0.876 | 0.300 | 1 | 0.849 |
PIM3 |
0.868 | 0.181 | -3 | 0.898 |
MOS |
0.868 | 0.220 | 1 | 0.889 |
CDC7 |
0.866 | 0.099 | 1 | 0.861 |
ERK5 |
0.864 | 0.207 | 1 | 0.875 |
PRPK |
0.863 | -0.041 | -1 | 0.866 |
CDKL1 |
0.863 | 0.171 | -3 | 0.873 |
KIS |
0.863 | 0.171 | 1 | 0.737 |
NLK |
0.862 | 0.108 | 1 | 0.823 |
CDKL5 |
0.861 | 0.203 | -3 | 0.868 |
SRPK1 |
0.861 | 0.194 | -3 | 0.829 |
NDR2 |
0.861 | 0.089 | -3 | 0.894 |
PRKD1 |
0.860 | 0.162 | -3 | 0.880 |
DSTYK |
0.860 | 0.022 | 2 | 0.877 |
CAMK1B |
0.860 | 0.096 | -3 | 0.915 |
MTOR |
0.859 | -0.047 | 1 | 0.778 |
MST4 |
0.859 | 0.133 | 2 | 0.859 |
RSK2 |
0.858 | 0.170 | -3 | 0.850 |
PKN3 |
0.858 | 0.123 | -3 | 0.886 |
NUAK2 |
0.858 | 0.131 | -3 | 0.895 |
IKKB |
0.858 | -0.096 | -2 | 0.773 |
SKMLCK |
0.857 | 0.155 | -2 | 0.886 |
ATR |
0.857 | 0.021 | 1 | 0.824 |
PIM1 |
0.857 | 0.185 | -3 | 0.849 |
RAF1 |
0.856 | -0.092 | 1 | 0.794 |
PRKD2 |
0.856 | 0.165 | -3 | 0.840 |
GRK1 |
0.856 | 0.155 | -2 | 0.863 |
WNK1 |
0.855 | 0.072 | -2 | 0.878 |
BMPR2 |
0.855 | -0.106 | -2 | 0.886 |
CAMLCK |
0.854 | 0.127 | -2 | 0.878 |
GCN2 |
0.854 | -0.159 | 2 | 0.787 |
AURC |
0.854 | 0.187 | -2 | 0.716 |
PKN2 |
0.854 | 0.121 | -3 | 0.889 |
NDR1 |
0.853 | 0.070 | -3 | 0.893 |
NIK |
0.853 | 0.063 | -3 | 0.921 |
CAMK2G |
0.852 | -0.080 | 2 | 0.773 |
RSK3 |
0.852 | 0.139 | -3 | 0.843 |
P90RSK |
0.852 | 0.124 | -3 | 0.851 |
DAPK2 |
0.852 | 0.121 | -3 | 0.921 |
NEK6 |
0.852 | -0.016 | -2 | 0.863 |
ULK2 |
0.852 | -0.142 | 2 | 0.780 |
PKCD |
0.852 | 0.128 | 2 | 0.793 |
HIPK4 |
0.851 | 0.112 | 1 | 0.786 |
P70S6KB |
0.851 | 0.125 | -3 | 0.868 |
ICK |
0.851 | 0.126 | -3 | 0.901 |
PKACG |
0.851 | 0.123 | -2 | 0.793 |
TGFBR2 |
0.851 | -0.020 | -2 | 0.823 |
PDHK4 |
0.851 | -0.328 | 1 | 0.819 |
RIPK3 |
0.851 | -0.032 | 3 | 0.768 |
AMPKA1 |
0.850 | 0.080 | -3 | 0.902 |
CLK2 |
0.850 | 0.277 | -3 | 0.822 |
NEK7 |
0.849 | -0.116 | -3 | 0.866 |
TBK1 |
0.849 | -0.186 | 1 | 0.689 |
MLK1 |
0.848 | -0.053 | 2 | 0.817 |
CLK4 |
0.848 | 0.209 | -3 | 0.838 |
SRPK2 |
0.848 | 0.159 | -3 | 0.762 |
MARK4 |
0.847 | 0.002 | 4 | 0.802 |
GRK5 |
0.847 | -0.115 | -3 | 0.868 |
SRPK3 |
0.847 | 0.142 | -3 | 0.801 |
TSSK2 |
0.847 | 0.088 | -5 | 0.904 |
DYRK2 |
0.846 | 0.143 | 1 | 0.719 |
CLK1 |
0.846 | 0.215 | -3 | 0.820 |
TSSK1 |
0.846 | 0.101 | -3 | 0.913 |
FAM20C |
0.846 | 0.074 | 2 | 0.591 |
CHAK2 |
0.845 | -0.026 | -1 | 0.835 |
AMPKA2 |
0.845 | 0.085 | -3 | 0.879 |
PKACB |
0.845 | 0.191 | -2 | 0.733 |
MNK2 |
0.845 | 0.125 | -2 | 0.813 |
PDHK1 |
0.845 | -0.284 | 1 | 0.808 |
IKKE |
0.844 | -0.201 | 1 | 0.679 |
PAK1 |
0.844 | 0.093 | -2 | 0.818 |
WNK3 |
0.843 | -0.157 | 1 | 0.779 |
LATS2 |
0.843 | 0.005 | -5 | 0.778 |
HUNK |
0.843 | -0.115 | 2 | 0.792 |
AURB |
0.843 | 0.142 | -2 | 0.715 |
CAMK2D |
0.843 | -0.030 | -3 | 0.904 |
PRKD3 |
0.843 | 0.126 | -3 | 0.819 |
NIM1 |
0.843 | 0.009 | 3 | 0.785 |
MAPKAPK3 |
0.842 | 0.034 | -3 | 0.850 |
RSK4 |
0.842 | 0.159 | -3 | 0.820 |
SGK3 |
0.842 | 0.176 | -3 | 0.839 |
MAPKAPK2 |
0.842 | 0.087 | -3 | 0.812 |
BMPR1B |
0.842 | 0.113 | 1 | 0.777 |
CDK5 |
0.842 | 0.143 | 1 | 0.715 |
PKCB |
0.842 | 0.111 | 2 | 0.749 |
PAK3 |
0.842 | 0.058 | -2 | 0.813 |
GRK7 |
0.842 | 0.117 | 1 | 0.754 |
IKKA |
0.841 | -0.073 | -2 | 0.752 |
HIPK1 |
0.841 | 0.186 | 1 | 0.733 |
ATM |
0.841 | 0.004 | 1 | 0.771 |
NUAK1 |
0.841 | 0.061 | -3 | 0.858 |
MSK2 |
0.841 | 0.090 | -3 | 0.823 |
IRE1 |
0.841 | -0.038 | 1 | 0.759 |
MNK1 |
0.840 | 0.118 | -2 | 0.823 |
PKG2 |
0.840 | 0.146 | -2 | 0.729 |
RIPK1 |
0.840 | -0.113 | 1 | 0.774 |
PKCA |
0.840 | 0.101 | 2 | 0.742 |
LATS1 |
0.840 | 0.108 | -3 | 0.907 |
PKR |
0.840 | 0.068 | 1 | 0.802 |
CAMK4 |
0.840 | 0.005 | -3 | 0.877 |
CDK8 |
0.840 | 0.034 | 1 | 0.686 |
CDK1 |
0.839 | 0.135 | 1 | 0.646 |
GRK6 |
0.839 | -0.077 | 1 | 0.803 |
PRKX |
0.839 | 0.195 | -3 | 0.763 |
ULK1 |
0.839 | -0.211 | -3 | 0.823 |
AKT2 |
0.839 | 0.171 | -3 | 0.774 |
MASTL |
0.839 | -0.249 | -2 | 0.816 |
PIM2 |
0.838 | 0.167 | -3 | 0.828 |
MELK |
0.838 | 0.051 | -3 | 0.870 |
HIPK2 |
0.838 | 0.168 | 1 | 0.637 |
PKCG |
0.838 | 0.066 | 2 | 0.741 |
MYLK4 |
0.838 | 0.111 | -2 | 0.826 |
NEK9 |
0.838 | -0.158 | 2 | 0.838 |
CAMK2B |
0.838 | 0.024 | 2 | 0.751 |
CDK7 |
0.837 | 0.050 | 1 | 0.701 |
MSK1 |
0.837 | 0.126 | -3 | 0.827 |
ANKRD3 |
0.837 | -0.138 | 1 | 0.819 |
CDK18 |
0.837 | 0.107 | 1 | 0.636 |
TTBK2 |
0.836 | -0.152 | 2 | 0.691 |
PKCZ |
0.836 | 0.064 | 2 | 0.791 |
CDK13 |
0.836 | 0.062 | 1 | 0.677 |
BCKDK |
0.836 | -0.225 | -1 | 0.789 |
MLK2 |
0.836 | -0.116 | 2 | 0.813 |
ALK4 |
0.835 | -0.046 | -2 | 0.839 |
TGFBR1 |
0.835 | 0.001 | -2 | 0.815 |
GRK4 |
0.835 | -0.126 | -2 | 0.886 |
PKCH |
0.835 | 0.061 | 2 | 0.728 |
IRE2 |
0.835 | -0.034 | 2 | 0.760 |
JNK3 |
0.835 | 0.094 | 1 | 0.687 |
CDK19 |
0.835 | 0.042 | 1 | 0.649 |
JNK2 |
0.834 | 0.108 | 1 | 0.643 |
PAK6 |
0.834 | 0.079 | -2 | 0.739 |
DLK |
0.834 | -0.220 | 1 | 0.789 |
CDK2 |
0.834 | 0.132 | 1 | 0.713 |
HIPK3 |
0.834 | 0.146 | 1 | 0.740 |
QIK |
0.834 | -0.047 | -3 | 0.898 |
MLK3 |
0.834 | -0.043 | 2 | 0.745 |
QSK |
0.834 | 0.021 | 4 | 0.765 |
CDK3 |
0.833 | 0.194 | 1 | 0.601 |
ALK2 |
0.833 | 0.056 | -2 | 0.836 |
P38A |
0.833 | 0.079 | 1 | 0.749 |
PAK2 |
0.832 | 0.020 | -2 | 0.806 |
AURA |
0.832 | 0.101 | -2 | 0.696 |
CAMK2A |
0.832 | 0.014 | 2 | 0.754 |
VRK2 |
0.832 | -0.143 | 1 | 0.854 |
PHKG1 |
0.832 | -0.003 | -3 | 0.887 |
ERK1 |
0.831 | 0.080 | 1 | 0.675 |
PLK1 |
0.831 | -0.099 | -2 | 0.821 |
CDK12 |
0.831 | 0.073 | 1 | 0.649 |
SIK |
0.831 | 0.027 | -3 | 0.838 |
ACVR2B |
0.831 | 0.010 | -2 | 0.822 |
P38B |
0.831 | 0.097 | 1 | 0.694 |
CDK9 |
0.831 | 0.060 | 1 | 0.684 |
DYRK1A |
0.831 | 0.120 | 1 | 0.760 |
NEK2 |
0.830 | -0.066 | 2 | 0.811 |
ACVR2A |
0.830 | -0.017 | -2 | 0.807 |
DYRK4 |
0.830 | 0.139 | 1 | 0.654 |
MEK1 |
0.829 | -0.196 | 2 | 0.807 |
PRP4 |
0.829 | 0.082 | -3 | 0.789 |
PKACA |
0.829 | 0.162 | -2 | 0.682 |
CDK17 |
0.828 | 0.078 | 1 | 0.578 |
AKT1 |
0.828 | 0.160 | -3 | 0.792 |
P38G |
0.828 | 0.088 | 1 | 0.575 |
SMG1 |
0.828 | -0.062 | 1 | 0.776 |
DYRK3 |
0.828 | 0.156 | 1 | 0.732 |
YSK4 |
0.827 | -0.143 | 1 | 0.726 |
DNAPK |
0.827 | -0.007 | 1 | 0.686 |
CDK14 |
0.826 | 0.102 | 1 | 0.663 |
PKCT |
0.826 | 0.077 | 2 | 0.738 |
CDK10 |
0.826 | 0.135 | 1 | 0.650 |
ERK2 |
0.826 | 0.036 | 1 | 0.704 |
MLK4 |
0.825 | -0.095 | 2 | 0.734 |
DCAMKL1 |
0.825 | 0.055 | -3 | 0.848 |
CHK1 |
0.825 | -0.018 | -3 | 0.875 |
CAMK1G |
0.825 | 0.031 | -3 | 0.837 |
MST3 |
0.825 | 0.061 | 2 | 0.839 |
PERK |
0.825 | -0.104 | -2 | 0.854 |
CHAK1 |
0.824 | -0.141 | 2 | 0.751 |
DYRK1B |
0.824 | 0.115 | 1 | 0.666 |
WNK4 |
0.824 | -0.054 | -2 | 0.858 |
MARK3 |
0.824 | -0.030 | 4 | 0.734 |
MARK2 |
0.824 | -0.043 | 4 | 0.705 |
SMMLCK |
0.824 | 0.076 | -3 | 0.884 |
ERK7 |
0.824 | 0.133 | 2 | 0.608 |
IRAK4 |
0.824 | -0.044 | 1 | 0.775 |
P70S6K |
0.824 | 0.080 | -3 | 0.794 |
BMPR1A |
0.823 | 0.066 | 1 | 0.767 |
BRAF |
0.823 | -0.092 | -4 | 0.760 |
BRSK1 |
0.823 | -0.041 | -3 | 0.861 |
SSTK |
0.823 | 0.037 | 4 | 0.753 |
MPSK1 |
0.823 | 0.069 | 1 | 0.761 |
DRAK1 |
0.822 | -0.093 | 1 | 0.697 |
MAPKAPK5 |
0.822 | -0.060 | -3 | 0.803 |
DAPK3 |
0.822 | 0.153 | -3 | 0.868 |
SNRK |
0.822 | -0.147 | 2 | 0.664 |
PKCI |
0.822 | 0.079 | 2 | 0.761 |
MEKK3 |
0.822 | -0.129 | 1 | 0.753 |
BRSK2 |
0.821 | -0.090 | -3 | 0.881 |
P38D |
0.821 | 0.093 | 1 | 0.612 |
MAK |
0.821 | 0.196 | -2 | 0.701 |
HRI |
0.821 | -0.170 | -2 | 0.856 |
PLK4 |
0.821 | -0.117 | 2 | 0.600 |
MEKK2 |
0.820 | -0.086 | 2 | 0.795 |
PKCE |
0.820 | 0.123 | 2 | 0.729 |
MEK5 |
0.820 | -0.227 | 2 | 0.808 |
PASK |
0.820 | 0.031 | -3 | 0.907 |
GRK2 |
0.819 | -0.099 | -2 | 0.777 |
TAO3 |
0.819 | -0.011 | 1 | 0.754 |
NEK5 |
0.819 | -0.096 | 1 | 0.799 |
GSK3A |
0.819 | 0.049 | 4 | 0.475 |
GAK |
0.819 | 0.076 | 1 | 0.821 |
CK1E |
0.819 | -0.019 | -3 | 0.510 |
CDK16 |
0.818 | 0.083 | 1 | 0.601 |
TLK2 |
0.818 | -0.172 | 1 | 0.739 |
MEKK1 |
0.818 | -0.174 | 1 | 0.776 |
MARK1 |
0.818 | -0.076 | 4 | 0.756 |
PLK3 |
0.818 | -0.152 | 2 | 0.742 |
SGK1 |
0.818 | 0.170 | -3 | 0.703 |
AKT3 |
0.817 | 0.165 | -3 | 0.717 |
GSK3B |
0.817 | 0.003 | 4 | 0.462 |
ZAK |
0.817 | -0.169 | 1 | 0.746 |
PINK1 |
0.816 | -0.190 | 1 | 0.800 |
DCAMKL2 |
0.816 | -0.006 | -3 | 0.871 |
PHKG2 |
0.816 | -0.012 | -3 | 0.857 |
CAMK1D |
0.815 | 0.067 | -3 | 0.779 |
EEF2K |
0.814 | 0.077 | 3 | 0.867 |
PKN1 |
0.814 | 0.094 | -3 | 0.809 |
DAPK1 |
0.813 | 0.114 | -3 | 0.852 |
PDK1 |
0.813 | -0.018 | 1 | 0.781 |
TAO2 |
0.813 | -0.048 | 2 | 0.841 |
PAK5 |
0.813 | 0.033 | -2 | 0.679 |
CK1D |
0.812 | -0.012 | -3 | 0.461 |
CDK6 |
0.812 | 0.093 | 1 | 0.654 |
MRCKB |
0.811 | 0.132 | -3 | 0.818 |
MOK |
0.811 | 0.154 | 1 | 0.770 |
NEK8 |
0.811 | -0.138 | 2 | 0.818 |
TLK1 |
0.810 | -0.192 | -2 | 0.861 |
ROCK2 |
0.810 | 0.140 | -3 | 0.857 |
TNIK |
0.810 | 0.050 | 3 | 0.900 |
CAMKK1 |
0.809 | -0.178 | -2 | 0.755 |
LKB1 |
0.809 | -0.095 | -3 | 0.869 |
BUB1 |
0.809 | 0.113 | -5 | 0.840 |
JNK1 |
0.809 | 0.042 | 1 | 0.631 |
PAK4 |
0.808 | 0.035 | -2 | 0.686 |
NEK11 |
0.808 | -0.180 | 1 | 0.740 |
TTBK1 |
0.808 | -0.199 | 2 | 0.607 |
CHK2 |
0.808 | 0.088 | -3 | 0.725 |
MEKK6 |
0.808 | -0.046 | 1 | 0.773 |
CDK4 |
0.808 | 0.075 | 1 | 0.635 |
MRCKA |
0.808 | 0.109 | -3 | 0.835 |
GRK3 |
0.807 | -0.078 | -2 | 0.750 |
CK1G1 |
0.807 | -0.090 | -3 | 0.512 |
MINK |
0.807 | -0.029 | 1 | 0.726 |
LRRK2 |
0.807 | -0.059 | 2 | 0.839 |
HGK |
0.806 | -0.030 | 3 | 0.901 |
CK2A2 |
0.806 | 0.046 | 1 | 0.706 |
GCK |
0.806 | -0.042 | 1 | 0.713 |
CK1A2 |
0.806 | -0.042 | -3 | 0.461 |
DMPK1 |
0.806 | 0.173 | -3 | 0.832 |
IRAK1 |
0.806 | -0.269 | -1 | 0.756 |
MAP3K15 |
0.805 | -0.085 | 1 | 0.739 |
NEK4 |
0.805 | -0.147 | 1 | 0.740 |
CAMKK2 |
0.805 | -0.168 | -2 | 0.744 |
MST2 |
0.804 | -0.116 | 1 | 0.748 |
LOK |
0.804 | -0.035 | -2 | 0.776 |
TAK1 |
0.803 | -0.106 | 1 | 0.770 |
PBK |
0.803 | 0.036 | 1 | 0.768 |
HPK1 |
0.803 | -0.033 | 1 | 0.697 |
SBK |
0.803 | 0.118 | -3 | 0.666 |
NEK1 |
0.802 | -0.093 | 1 | 0.771 |
CAMK1A |
0.802 | 0.070 | -3 | 0.741 |
KHS2 |
0.801 | 0.043 | 1 | 0.709 |
PDHK3_TYR |
0.801 | 0.138 | 4 | 0.876 |
KHS1 |
0.800 | 0.001 | 1 | 0.711 |
VRK1 |
0.800 | -0.153 | 2 | 0.834 |
PKG1 |
0.799 | 0.083 | -2 | 0.658 |
CRIK |
0.798 | 0.138 | -3 | 0.792 |
ROCK1 |
0.798 | 0.127 | -3 | 0.828 |
YSK1 |
0.797 | -0.054 | 2 | 0.816 |
SLK |
0.797 | -0.076 | -2 | 0.724 |
MST1 |
0.796 | -0.132 | 1 | 0.728 |
CK2A1 |
0.795 | 0.018 | 1 | 0.676 |
PKMYT1_TYR |
0.794 | 0.047 | 3 | 0.864 |
STK33 |
0.794 | -0.175 | 2 | 0.601 |
TESK1_TYR |
0.794 | -0.003 | 3 | 0.894 |
HASPIN |
0.793 | 0.019 | -1 | 0.722 |
MAP2K4_TYR |
0.793 | -0.016 | -1 | 0.880 |
TTK |
0.792 | -0.005 | -2 | 0.846 |
MEK2 |
0.792 | -0.264 | 2 | 0.780 |
PLK2 |
0.791 | -0.111 | -3 | 0.767 |
RIPK2 |
0.791 | -0.280 | 1 | 0.709 |
EPHA6 |
0.790 | 0.138 | -1 | 0.843 |
PDHK4_TYR |
0.790 | -0.007 | 2 | 0.858 |
NEK3 |
0.790 | -0.144 | 1 | 0.746 |
MAP2K6_TYR |
0.789 | -0.038 | -1 | 0.873 |
LIMK2_TYR |
0.789 | 0.033 | -3 | 0.926 |
PINK1_TYR |
0.789 | -0.081 | 1 | 0.827 |
BIKE |
0.788 | 0.026 | 1 | 0.713 |
MAP2K7_TYR |
0.788 | -0.197 | 2 | 0.828 |
BMPR2_TYR |
0.786 | -0.035 | -1 | 0.862 |
OSR1 |
0.786 | -0.088 | 2 | 0.802 |
EPHB4 |
0.785 | 0.055 | -1 | 0.817 |
MYO3B |
0.785 | -0.023 | 2 | 0.820 |
PDHK1_TYR |
0.785 | -0.104 | -1 | 0.883 |
ALPHAK3 |
0.783 | -0.028 | -1 | 0.774 |
ROS1 |
0.783 | -0.023 | 3 | 0.818 |
TYRO3 |
0.783 | -0.040 | 3 | 0.845 |
ABL2 |
0.782 | 0.057 | -1 | 0.811 |
TYK2 |
0.782 | -0.118 | 1 | 0.793 |
RET |
0.782 | -0.118 | 1 | 0.791 |
TNK2 |
0.781 | 0.065 | 3 | 0.794 |
LIMK1_TYR |
0.781 | -0.129 | 2 | 0.831 |
MST1R |
0.781 | -0.098 | 3 | 0.842 |
BLK |
0.781 | 0.142 | -1 | 0.841 |
TXK |
0.780 | 0.078 | 1 | 0.821 |
YANK3 |
0.780 | -0.079 | 2 | 0.402 |
JAK2 |
0.780 | -0.099 | 1 | 0.797 |
TAO1 |
0.780 | -0.094 | 1 | 0.687 |
ASK1 |
0.779 | -0.178 | 1 | 0.733 |
DDR1 |
0.779 | -0.087 | 4 | 0.796 |
YES1 |
0.779 | -0.015 | -1 | 0.843 |
MYO3A |
0.778 | -0.087 | 1 | 0.710 |
LCK |
0.778 | 0.080 | -1 | 0.829 |
HCK |
0.778 | 0.016 | -1 | 0.829 |
ABL1 |
0.778 | 0.037 | -1 | 0.804 |
FER |
0.777 | -0.041 | 1 | 0.878 |
CSF1R |
0.777 | -0.101 | 3 | 0.827 |
FGR |
0.777 | -0.042 | 1 | 0.841 |
TNNI3K_TYR |
0.776 | 0.054 | 1 | 0.818 |
EPHA4 |
0.776 | 0.012 | 2 | 0.746 |
ITK |
0.775 | -0.001 | -1 | 0.799 |
SRMS |
0.774 | -0.009 | 1 | 0.846 |
AAK1 |
0.774 | 0.069 | 1 | 0.621 |
INSRR |
0.774 | -0.081 | 3 | 0.785 |
EPHB1 |
0.774 | -0.022 | 1 | 0.847 |
EPHB2 |
0.773 | 0.022 | -1 | 0.791 |
EPHB3 |
0.773 | 0.003 | -1 | 0.802 |
JAK3 |
0.773 | -0.115 | 1 | 0.783 |
TNK1 |
0.772 | -0.044 | 3 | 0.813 |
JAK1 |
0.772 | -0.040 | 1 | 0.724 |
FLT3 |
0.771 | -0.109 | 3 | 0.835 |
TEC |
0.771 | 0.002 | -1 | 0.760 |
BMX |
0.770 | -0.004 | -1 | 0.730 |
CK1A |
0.769 | -0.076 | -3 | 0.364 |
PDGFRB |
0.769 | -0.164 | 3 | 0.843 |
KIT |
0.769 | -0.130 | 3 | 0.827 |
KDR |
0.769 | -0.101 | 3 | 0.786 |
MERTK |
0.768 | -0.050 | 3 | 0.793 |
AXL |
0.768 | -0.094 | 3 | 0.808 |
FYN |
0.768 | 0.045 | -1 | 0.815 |
TEK |
0.768 | -0.117 | 3 | 0.783 |
FGFR2 |
0.767 | -0.170 | 3 | 0.810 |
NEK10_TYR |
0.767 | -0.121 | 1 | 0.665 |
MET |
0.766 | -0.082 | 3 | 0.820 |
ALK |
0.766 | -0.090 | 3 | 0.762 |
LTK |
0.766 | -0.067 | 3 | 0.769 |
WEE1_TYR |
0.765 | -0.085 | -1 | 0.759 |
BTK |
0.765 | -0.132 | -1 | 0.770 |
DDR2 |
0.765 | 0.014 | 3 | 0.771 |
EPHA7 |
0.764 | -0.021 | 2 | 0.753 |
FGFR1 |
0.764 | -0.174 | 3 | 0.797 |
LYN |
0.763 | -0.033 | 3 | 0.745 |
FRK |
0.762 | -0.053 | -1 | 0.844 |
EPHA1 |
0.761 | -0.065 | 3 | 0.802 |
PDGFRA |
0.761 | -0.236 | 3 | 0.843 |
PTK2B |
0.760 | -0.027 | -1 | 0.783 |
STLK3 |
0.760 | -0.285 | 1 | 0.707 |
EPHA3 |
0.759 | -0.117 | 2 | 0.720 |
EPHA5 |
0.757 | -0.034 | 2 | 0.730 |
FGFR3 |
0.757 | -0.166 | 3 | 0.788 |
SRC |
0.756 | -0.047 | -1 | 0.812 |
NTRK1 |
0.756 | -0.239 | -1 | 0.796 |
FLT1 |
0.756 | -0.161 | -1 | 0.803 |
INSR |
0.755 | -0.175 | 3 | 0.766 |
ERBB2 |
0.755 | -0.195 | 1 | 0.739 |
PTK6 |
0.755 | -0.234 | -1 | 0.727 |
MATK |
0.755 | -0.113 | -1 | 0.733 |
EPHA8 |
0.754 | -0.059 | -1 | 0.795 |
NTRK2 |
0.753 | -0.241 | 3 | 0.787 |
SYK |
0.752 | 0.035 | -1 | 0.756 |
FLT4 |
0.751 | -0.234 | 3 | 0.765 |
NTRK3 |
0.751 | -0.176 | -1 | 0.749 |
EGFR |
0.749 | -0.118 | 1 | 0.666 |
PTK2 |
0.749 | -0.015 | -1 | 0.755 |
CSK |
0.747 | -0.177 | 2 | 0.754 |
CK1G3 |
0.747 | -0.098 | -3 | 0.320 |
YANK2 |
0.743 | -0.126 | 2 | 0.416 |
MUSK |
0.743 | -0.146 | 1 | 0.655 |
FGFR4 |
0.743 | -0.160 | -1 | 0.750 |
EPHA2 |
0.742 | -0.084 | -1 | 0.747 |
IGF1R |
0.741 | -0.166 | 3 | 0.704 |
ERBB4 |
0.738 | -0.074 | 1 | 0.668 |
CK1G2 |
0.734 | -0.061 | -3 | 0.420 |
ZAP70 |
0.731 | -0.027 | -1 | 0.685 |
FES |
0.730 | -0.143 | -1 | 0.704 |