Motif 960 (n=173)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S497 | ochoa | Golgin A8 family member Q | None |
| A0A1W2PNV4 | None | S642 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| H3BSY2 | GOLGA8M | S497 | ochoa | Golgin subfamily A member 8M | None |
| H7BYZ3 | None | S25 | ochoa | EF-hand domain-containing protein | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000256|ARBA:ARBA00023754}. |
| I6L899 | GOLGA8R | S496 | ochoa | Golgin subfamily A member 8R | None |
| O00159 | MYO1C | S29 | ochoa | Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}. |
| O00401 | WASL | S426 | ochoa | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828, ECO:0000269|PubMed:9422512}. |
| O14686 | KMT2D | S2970 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14795 | UNC13B | S917 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O14920 | IKBKB | S258 | psp | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O14980 | XPO1 | S450 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15061 | SYNM | S1540 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15143 | ARPC1B | S310 | ochoa | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O15417 | TNRC18 | S2771 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43541 | SMAD6 | S435 | psp | Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6) | Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (PubMed:10647776, PubMed:10708948, PubMed:10708949, PubMed:16951688, PubMed:22275001, PubMed:30848080, PubMed:9436979, PubMed:9759503). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (PubMed:30848080, PubMed:9436979). Binds to regulatory elements in target promoter regions (PubMed:16491121). {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:22275001, ECO:0000269|PubMed:30848080, ECO:0000269|PubMed:9436979, ECO:0000303|PubMed:10647776, ECO:0000303|PubMed:10708948, ECO:0000303|PubMed:10708949, ECO:0000303|PubMed:9759503}. |
| O60784 | TOM1 | S405 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O94851 | MICAL2 | S631 | ochoa | [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2) | Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334, PubMed:29343822). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network (PubMed:34106209). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334). {ECO:0000269|PubMed:24440334, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:34106209}. |
| O94906 | PRPF6 | S263 | ochoa | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}. |
| O95235 | KIF20A | S433 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95551 | TDP2 | S60 | psp | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27060144, PubMed:27099339). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584, ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489, ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062, ECO:0000269|PubMed:24658003, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339}.; FUNCTION: (Microbial infection) Used by picornaviruses to remove the small polypeptide, VPg (virus Protein genome-linked, the primer for viral RNA synthesis), from the genomic RNA of the virus. Acts as a 5'-tyrosyl RNA phosphodiesterase and cleaves the covalent VPg-Tyr-RNA bond. This cleavage would play a role in viral replication and occur in viral replication vesicles, but would not act on viral mRNA. {ECO:0000269|PubMed:22908287, ECO:0000269|PubMed:32023921}. |
| P00338 | LDHA | S167 | ochoa | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P02647 | APOA1 | S191 | ochoa | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. |
| P04075 | ALDOA | S218 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05976 | MYL1 | S68 | ochoa | Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2) | Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. {ECO:0000269|PubMed:30215711}. |
| P06732 | CKM | S224 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P07195 | LDHB | S168 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07864 | LDHC | S167 | ochoa | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | Possible role in sperm motility. |
| P09651 | HNRNPA1 | S91 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P0DMU7 | CT45A6 | S24 | ochoa | Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) | None |
| P0DMU8 | CT45A5 | S24 | ochoa | Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) | None |
| P0DMU9 | CT45A10 | S24 | ochoa | Cancer/testis antigen family 45 member A10 (Cancer/testis antigen 45A10) | None |
| P0DMV0 | CT45A7 | S24 | ochoa | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | None |
| P0DMV1 | CT45A8 | S24 | ochoa | Cancer/testis antigen family 45 member A8 (Cancer/testis antigen 45A8) | None |
| P0DMV2 | CT45A9 | S24 | ochoa | Cancer/testis antigen family 45 member A9 (Cancer/testis antigen 45A9) | None |
| P10242 | MYB | S463 | ochoa | Transcriptional activator Myb (Proto-oncogene c-Myb) | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| P12081 | HARS1 | S27 | ochoa | Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) | Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516). {ECO:0000269|PubMed:26072516, ECO:0000269|PubMed:29235198}. |
| P12429 | ANXA3 | S145 | ochoa | Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) | Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. |
| P14625 | HSP90B1 | S109 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15735 | PHKG2 | S269 | ochoa | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| P16615 | ATP2A2 | S38 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P21980 | TGM2 | S68 | psp | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P27708 | CAD | S1267 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P29218 | IMPA1 | S165 | ochoa | Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) | Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol (PubMed:17068342, PubMed:8718889, PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (PubMed:17068342). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:17068342, PubMed:8718889, PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function (PubMed:26416544, PubMed:8718889). Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder (PubMed:17068342). Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate (PubMed:9462881). {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:26416544, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}. |
| P30414 | NKTR | S1276 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P35125 | USP6 | S1214 | ochoa | Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (RN-tre) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) | Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A (PubMed:19077034). {ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172, ECO:0000269|PubMed:19077034, ECO:0000269|PubMed:20418905}. |
| P36382 | GJA5 | S122 | ochoa | Gap junction alpha-5 protein (Connexin-40) (Cx40) | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| P36956 | SREBF1 | S338 | psp | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. |
| P40429 | RPL13A | S77 | psp | Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a) | Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318). {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P41227 | NAA10 | S189 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P46734 | MAP2K3 | S253 | ochoa | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P48163 | ME1 | S336 | psp | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:7757881, ECO:0000269|PubMed:8187880, ECO:0000269|PubMed:8804575}. |
| P49069 | CAMLG | S20 | ochoa | Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250|UniProtKB:P49070, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:32187542, ECO:0000269|PubMed:7522304}. |
| P49327 | FASN | S1028 | psp | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49327 | FASN | S1254 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49773 | HINT1 | S102 | ochoa | Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:15703176, PubMed:16835243, PubMed:17217311, PubMed:17337452, PubMed:22329685, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed:15703176, PubMed:16835243). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (PubMed:15703176, PubMed:17337452, PubMed:22329685). Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17217311, PubMed:17337452, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed:30772266). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed:16014379, PubMed:22647378). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed:16835243). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:19112177). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17 (PubMed:31088288). Deconjugates SUMO1 from RANGAP1 (By similarity). {ECO:0000250|UniProtKB:P80912, ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243, ECO:0000269|PubMed:17217311, ECO:0000269|PubMed:17337452, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:23614568, ECO:0000269|PubMed:28691797, ECO:0000269|PubMed:29787766, ECO:0000269|PubMed:30772266, ECO:0000269|PubMed:31088288, ECO:0000269|PubMed:31990367}. |
| P51991 | HNRNPA3 | S112 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P53794 | SLC5A3 | S594 | ochoa | Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) | Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity) (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553). {ECO:0000250|UniProtKB:P31637, ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:27217553, ECO:0000269|PubMed:28793216}. |
| P60880 | SNAP25 | S154 | ochoa | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) | t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {ECO:0000250|UniProtKB:P60881}. |
| P63098 | PPP3R1 | S35 | ochoa | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000269|PubMed:26794871}. |
| P98175 | RBM10 | S207 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| P98196 | ATP11A | S738 | ochoa | Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401, PubMed:36300302). Does not show flippase activity toward phosphatidylcholine (PC) (PubMed:34403372). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. {ECO:0000269|PubMed:15860663, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:26567335, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:30018401, ECO:0000269|PubMed:34403372, ECO:0000269|PubMed:36300302, ECO:0000305}. |
| Q02241 | KIF23 | S160 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02952 | AKAP12 | S505 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S376 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q05682 | CALD1 | S691 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q12986 | NFX1 | S123 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13009 | TIAM1 | S334 | psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13464 | ROCK1 | S479 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q14134 | TRIM29 | S58 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14151 | SAFB2 | S109 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14451 | GRB7 | S361 | ochoa|psp | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14689 | DIP2A | S94 | ochoa | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) | Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}. |
| Q15185 | PTGES3 | S85 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15906 | VPS72 | S107 | ochoa | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| Q16531 | DDB1 | S1101 | ochoa | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMed:16482215, PubMed:16940174, PubMed:17079684). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:38316879}. |
| Q16666 | IFI16 | S572 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q16891 | IMMT | S350 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q16891 | IMMT | S390 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q17RH5 | RAPGEF2 | S921 | psp | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | None |
| Q2KHR3 | QSER1 | S615 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2M2Z5 | KIZ | S647 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q32P51 | HNRNPA1L2 | S91 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q53EL6 | PDCD4 | S323 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5DJT8 | CT45A2 | S24 | ochoa | Cancer/testis antigen family 45 member A2 (Cancer/testis antigen 45-2) (Cancer/testis antigen 45A2) | None |
| Q5HYN5 | CT45A1 | S24 | ochoa | Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) | None |
| Q5JSZ5 | PRRC2B | S1399 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SQS7 | SH2D4B | S361 | ochoa | SH2 domain-containing protein 4B | None |
| Q5UIP0 | RIF1 | S20 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VYK3 | ECPAS | S1043 | ochoa | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}. |
| Q5VZL5 | ZMYM4 | S1244 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q6NXE6 | ARMC6 | S84 | ochoa | Armadillo repeat-containing protein 6 | None |
| Q6NXG1 | ESRP1 | S237 | ochoa | Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250|UniProtKB:Q3US41, ECO:0000269|PubMed:19285943}. |
| Q6P9B6 | MEAK7 | S425 | ochoa | MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) | Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
| Q6R327 | RICTOR | S1373 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6ZMR3 | LDHAL6A | S167 | ochoa | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed. {ECO:0000269|PubMed:18351441}. |
| Q76FK4 | NOL8 | S673 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7KZI7 | MARK2 | S722 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L5Y1 | ENOSF1 | S148 | psp | Mitochondrial enolase superfamily member 1 (EC 4.2.1.68) (Antisense RNA to thymidylate synthase) (rTS) (L-fuconate dehydratase) | Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329). {ECO:0000269|PubMed:24697329}. |
| Q7L622 | G2E3 | S292 | ochoa | G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. {ECO:0000269|PubMed:18511420}. |
| Q86TU7 | SETD3 | S512 | ochoa | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
| Q86VP1 | TAX1BP1 | S138 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q8NDI1 | EHBP1 | S577 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NEM2 | SHCBP1 | S574 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NEV8 | EXPH5 | S320 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NF91 | SYNE1 | S1361 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NHU0 | CT45A3 | S24 | ochoa | Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) | None |
| Q8NI08 | NCOA7 | S595 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TD55 | PLEKHO2 | S433 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TDJ6 | DMXL2 | S2123 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TEM1 | NUP210 | S144 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8TF72 | SHROOM3 | S318 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUM0 | NUP133 | S1133 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WWA1 | TMEM40 | S141 | ochoa | Transmembrane protein 40 | None |
| Q92551 | IP6K1 | S127 | ochoa | Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
| Q92575 | UBXN4 | S331 | ochoa | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}. |
| Q96CW5 | TUBGCP3 | S515 | ochoa | Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809, PubMed:9566967). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809, ECO:0000269|PubMed:9566967}. |
| Q96KP4 | CNDP2 | S58 | ochoa | Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase) | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:12473676, PubMed:19346245). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). {ECO:0000250|UniProtKB:Q9D1A2, ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568, ECO:0000269|PubMed:25964343}. |
| Q96PU4 | UHRF2 | S681 | ochoa | E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) | E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:24813944, PubMed:27129234). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Also ubiquitinates PCNP leading to its degradation by the proteasome (PubMed:12176013, PubMed:14741369). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395). {ECO:0000250|UniProtKB:Q7TMI3, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:24813944, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29506131, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:33848395}. |
| Q96Q89 | KIF20B | S1574 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96S82 | UBL7 | S123 | ochoa | Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132) | Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}. |
| Q96SN8 | CDK5RAP2 | S1244 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99081 | TCF12 | S332 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99497 | PARK7 | S47 | ochoa | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) | Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}. |
| Q99504 | EYA3 | S296 | ochoa | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q99570 | PIK3R4 | S813 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99801 | NKX3-1 | S186 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q9BRR0 | ZKSCAN3 | S210 | ochoa | Zinc finger protein with KRAB and SCAN domains 3 (Zinc finger and SCAN domain-containing protein 13) (Zinc finger protein 306) (Zinc finger protein 309) (Zinc finger protein 47 homolog) (Zf47) (Zfp-47) | Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. {ECO:0000269|PubMed:18940803, ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714, ECO:0000269|PubMed:23434374}. |
| Q9BTE7 | DCUN1D5 | S41 | ochoa | DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5) | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:19617556, PubMed:23201271, PubMed:26906416). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928). {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23098533, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:24192928, ECO:0000269|PubMed:26906416}. |
| Q9BX66 | SORBS1 | S374 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BYT3 | STK33 | S46 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9BZD6 | PRRG4 | S163 | ochoa | Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4) | May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (PubMed:28859078). {ECO:0000269|PubMed:28859078}. |
| Q9H0E3 | SAP130 | S855 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H5J8 | TAF1D | S234 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H6T0 | ESRP2 | S269 | ochoa | Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B) | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}. |
| Q9H714 | RUBCNL | S189 | ochoa | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}. |
| Q9H9Q4 | NHEJ1 | S203 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9HCP6 | HHATL | S233 | ochoa | Protein-cysteine N-palmitoyltransferase HHAT-like protein (Glycerol uptake/transporter homolog) (Hedgehog acyltransferase-like protein) | Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. {ECO:0000250}. |
| Q9NPG3 | UBN1 | S142 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQZ2 | UTP3 | S365 | ochoa | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}. |
| Q9NRY4 | ARHGAP35 | S589 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NUL7 | DDX28 | S127 | ochoa | Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) | Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}. |
| Q9P0M6 | MACROH2A2 | S341 | ochoa | Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}. |
| Q9P265 | DIP2B | S100 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UBL3 | ASH2L | S321 | ochoa | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| Q9UBT7 | CTNNAL1 | S538 | ochoa | Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) | May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). |
| Q9UPN4 | CEP131 | S512 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPU5 | USP24 | S2561 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPW8 | UNC13A | S993 | ochoa | Protein unc-13 homolog A (Munc13-1) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q4KUS2, ECO:0000250|UniProtKB:Q62768, ECO:0000269|PubMed:23999003}. |
| Q9UQR1 | ZNF148 | S202 | psp | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2E4 | DIP2C | S89 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y2X3 | NOP58 | S380 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y4F5 | CEP170B | S619 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4G8 | RAPGEF2 | S933 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y520 | PRRC2C | S893 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5Y0 | FLVCR1 | S536 | ochoa | Choline/ethanolamine transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (hFLVCR) (Heme transporter FLVCR1) | Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis (PubMed:37100056, PubMed:38693265, PubMed:38778100, PubMed:39306721). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265, PubMed:38778100). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265, PubMed:38778100). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065). {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:22483575, ECO:0000269|PubMed:23187127, ECO:0000269|PubMed:27923065, ECO:0000269|PubMed:37100056, ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0000269|PubMed:39306721}.; FUNCTION: [Isoform 1]: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells (PubMed:37100056, PubMed:38693265). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065). Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity (PubMed:20610401). Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies (PubMed:20610401, PubMed:23187127). Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway (PubMed:20610401). Does not export bilirubin (PubMed:20610401). The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (PubMed:20610401, PubMed:23187127). {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:22483575, ECO:0000269|PubMed:23187127, ECO:0000269|PubMed:27923065, ECO:0000269|PubMed:37100056, ECO:0000269|PubMed:38693265}.; FUNCTION: [Isoform 2]: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. {ECO:0000269|PubMed:23187127}.; FUNCTION: [Isoform 1]: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. {ECO:0000269|PubMed:10400745}. |
| Q9Y6Q9 | NCOA3 | S102 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9BUB5 | MKNK1 | S352 | SIGNOR | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| P13667 | PDIA4 | S379 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P11413 | G6PD | S117 | Sugiyama | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
| P33981 | TTK | S108 | SIGNOR|PSP | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P53671 | LIMK2 | S36 | Sugiyama | LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}. |
| O75128 | COBL | S1174 | Sugiyama | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| P35568 | IRS1 | S99 | SIGNOR | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| Q02763 | TEK | S862 | Sugiyama | Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) | Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1. {ECO:0000269|PubMed:12816861, ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:18366015, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:20651738, ECO:0000269|PubMed:9204896}. |
| P39019 | RPS19 | S96 | Sugiyama | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q05513 | PRKCZ | S573 | Sugiyama | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q5TAX3 | TUT4 | S1383 | Sugiyama | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| P35613 | BSG | S229 | Sugiyama | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| Q16584 | MAP3K11 | S160 | Sugiyama | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q5S007 | LRRK2 | S1853 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| P13489 | RNH1 | S50 | Sugiyama | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}. |
| Q01581 | HMGCS1 | S324 | Sugiyama | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| P43243 | MATR3 | S114 | Sugiyama | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.000059 | 4.227 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.000241 | 3.617 |
| R-HSA-1989781 | PPARA activates gene expression | 0.000275 | 3.560 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.000299 | 3.524 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.000450 | 3.347 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.000699 | 3.156 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.001717 | 2.765 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.001717 | 2.765 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.003313 | 2.480 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.035321 | 1.452 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.035321 | 1.452 |
| R-HSA-5682113 | Defective ABCA1 causes TGD | 0.058175 | 1.235 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.069400 | 1.159 |
| R-HSA-74713 | IRS activation | 0.080491 | 1.094 |
| R-HSA-8964011 | HDL clearance | 0.102281 | 0.990 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 0.102281 | 0.990 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.004850 | 2.314 |
| R-HSA-112412 | SOS-mediated signalling | 0.112983 | 0.947 |
| R-HSA-210993 | Tie2 Signaling | 0.031576 | 1.501 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.134006 | 0.873 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.164616 | 0.784 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.184422 | 0.734 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.026497 | 1.577 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.070006 | 1.155 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.073387 | 1.134 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.073387 | 1.134 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.203761 | 0.691 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.080303 | 1.095 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.080303 | 1.095 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.083834 | 1.077 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.091034 | 1.041 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.105944 | 0.975 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.109769 | 0.960 |
| R-HSA-210991 | Basigin interactions | 0.267924 | 0.572 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.074548 | 1.128 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.137477 | 0.862 |
| R-HSA-380287 | Centrosome maturation | 0.078868 | 1.103 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.166506 | 0.779 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.104475 | 0.981 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.104475 | 0.981 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.111964 | 0.951 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.119653 | 0.922 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.122258 | 0.913 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.132883 | 0.877 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.135589 | 0.868 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.209510 | 0.679 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.209510 | 0.679 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.222638 | 0.652 |
| R-HSA-192823 | Viral mRNA Translation | 0.157887 | 0.802 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.172360 | 0.764 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.175299 | 0.756 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.175299 | 0.756 |
| R-HSA-72172 | mRNA Splicing | 0.133459 | 0.875 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.293238 | 0.533 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.114665 | 0.941 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.078570 | 1.105 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.144332 | 0.841 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.187194 | 0.728 |
| R-HSA-198203 | PI3K/AKT activation | 0.144332 | 0.841 |
| R-HSA-156902 | Peptide chain elongation | 0.111964 | 0.951 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.187194 | 0.728 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.070077 | 1.154 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.284694 | 0.546 |
| R-HSA-8964058 | HDL remodeling | 0.250136 | 0.602 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.236595 | 0.626 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.236595 | 0.626 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.236595 | 0.626 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.253477 | 0.596 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.091034 | 1.041 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.017374 | 1.760 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.102281 | 0.990 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.134006 | 0.873 |
| R-HSA-8963901 | Chylomicron remodeling | 0.184422 | 0.734 |
| R-HSA-8963896 | HDL assembly | 0.194149 | 0.712 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.087412 | 1.058 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.163630 | 0.786 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.163630 | 0.786 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.205411 | 0.687 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.030463 | 1.516 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.091451 | 1.039 |
| R-HSA-8963888 | Chylomicron assembly | 0.154534 | 0.811 |
| R-HSA-3000471 | Scavenging by Class B Receptors | 0.222644 | 0.652 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.276660 | 0.558 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.135589 | 0.868 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.036734 | 1.435 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.149394 | 0.826 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.244646 | 0.611 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.019456 | 1.711 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.205411 | 0.687 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.213259 | 0.671 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.104992 | 0.979 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.014291 | 1.845 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.091451 | 1.039 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.112983 | 0.947 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.112983 | 0.947 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.031576 | 1.501 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.164616 | 0.784 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.194149 | 0.712 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.194149 | 0.712 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.203761 | 0.691 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.098409 | 1.007 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.302251 | 0.520 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.200805 | 0.697 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.235828 | 0.627 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.230896 | 0.637 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.241081 | 0.618 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.302251 | 0.520 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.006412 | 2.193 |
| R-HSA-112399 | IRS-mediated signalling | 0.183536 | 0.736 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.124884 | 0.903 |
| R-HSA-74749 | Signal attenuation | 0.144332 | 0.841 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.250136 | 0.602 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.244646 | 0.611 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.284412 | 0.546 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.291182 | 0.536 |
| R-HSA-9664407 | Parasite infection | 0.291182 | 0.536 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.291182 | 0.536 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.112983 | 0.947 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.045026 | 1.347 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.027786 | 1.556 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.083834 | 1.077 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.213878 | 0.670 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.294431 | 0.531 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.137477 | 0.862 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.231425 | 0.636 |
| R-HSA-72312 | rRNA processing | 0.186845 | 0.729 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.213878 | 0.670 |
| R-HSA-429593 | Inositol transporters | 0.080491 | 1.094 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.039426 | 1.404 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.047930 | 1.319 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.050900 | 1.293 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.164616 | 0.784 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.164616 | 0.784 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.203761 | 0.691 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.250136 | 0.602 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.302251 | 0.520 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.192145 | 0.716 |
| R-HSA-191859 | snRNP Assembly | 0.192145 | 0.716 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.200805 | 0.697 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.240235 | 0.619 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.302048 | 0.520 |
| R-HSA-68877 | Mitotic Prometaphase | 0.043678 | 1.360 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.218254 | 0.661 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.017488 | 1.757 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.220889 | 0.656 |
| R-HSA-9842663 | Signaling by LTK | 0.174578 | 0.758 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.134006 | 0.873 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.174578 | 0.758 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.087412 | 1.058 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.259083 | 0.587 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.058516 | 1.233 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.152209 | 0.818 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.231425 | 0.636 |
| R-HSA-70268 | Pyruvate metabolism | 0.006337 | 2.198 |
| R-HSA-8939211 | ESR-mediated signaling | 0.090579 | 1.043 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.014291 | 1.845 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.057031 | 1.244 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.174578 | 0.758 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.174578 | 0.758 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.174578 | 0.758 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.194149 | 0.712 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.109769 | 0.960 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.113630 | 0.945 |
| R-HSA-429947 | Deadenylation of mRNA | 0.302251 | 0.520 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.166506 | 0.779 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.209510 | 0.679 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.160751 | 0.794 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.113275 | 0.946 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.213878 | 0.670 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.008107 | 2.091 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.203761 | 0.691 |
| R-HSA-9659379 | Sensory processing of sound | 0.279996 | 0.553 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.070006 | 1.155 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.244646 | 0.611 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.016382 | 1.786 |
| R-HSA-983189 | Kinesins | 0.049235 | 1.308 |
| R-HSA-8957322 | Metabolism of steroids | 0.121626 | 0.915 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.199292 | 0.701 |
| R-HSA-68886 | M Phase | 0.055216 | 1.258 |
| R-HSA-8953854 | Metabolism of RNA | 0.149253 | 0.826 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 0.080491 | 1.094 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.014291 | 1.845 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 0.091451 | 1.039 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 0.134006 | 0.873 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.154534 | 0.811 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.203761 | 0.691 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.203761 | 0.691 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.250136 | 0.602 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.117526 | 0.930 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.099598 | 1.002 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.249060 | 0.604 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.178253 | 0.749 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.275577 | 0.560 |
| R-HSA-75153 | Apoptotic execution phase | 0.137477 | 0.862 |
| R-HSA-8848021 | Signaling by PTK6 | 0.209510 | 0.679 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.209510 | 0.679 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.230288 | 0.638 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.241081 | 0.618 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.138313 | 0.859 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.306447 | 0.514 |
| R-HSA-3371556 | Cellular response to heat stress | 0.220889 | 0.656 |
| R-HSA-397014 | Muscle contraction | 0.303390 | 0.518 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.017961 | 1.746 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.091451 | 1.039 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.026734 | 1.573 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.231917 | 0.635 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.105944 | 0.975 |
| R-HSA-71288 | Creatine metabolism | 0.259083 | 0.587 |
| R-HSA-109704 | PI3K Cascade | 0.153929 | 0.813 |
| R-HSA-450294 | MAP kinase activation | 0.200805 | 0.697 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.012546 | 1.901 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.183536 | 0.736 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.187833 | 0.726 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.127395 | 0.895 |
| R-HSA-69275 | G2/M Transition | 0.232529 | 0.634 |
| R-HSA-373755 | Semaphorin interactions | 0.054634 | 1.263 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.237642 | 0.624 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.231917 | 0.635 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.205153 | 0.688 |
| R-HSA-448424 | Interleukin-17 signaling | 0.240235 | 0.619 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.020547 | 1.687 |
| R-HSA-168255 | Influenza Infection | 0.033130 | 1.480 |
| R-HSA-9834899 | Specification of the neural plate border | 0.250136 | 0.602 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.267924 | 0.572 |
| R-HSA-70171 | Glycolysis | 0.149394 | 0.826 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.250136 | 0.602 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.137477 | 0.862 |
| R-HSA-9707616 | Heme signaling | 0.205153 | 0.688 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.178779 | 0.748 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.174797 | 0.757 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.174578 | 0.758 |
| R-HSA-174403 | Glutathione synthesis and recycling | 0.276660 | 0.558 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.262100 | 0.582 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.022165 | 1.654 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.245361 | 0.610 |
| R-HSA-2586552 | Signaling by Leptin | 0.144332 | 0.841 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.250136 | 0.602 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.276660 | 0.558 |
| R-HSA-75893 | TNF signaling | 0.179254 | 0.747 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.202346 | 0.694 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.018072 | 1.743 |
| R-HSA-189451 | Heme biosynthesis | 0.117526 | 0.930 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.276660 | 0.558 |
| R-HSA-70326 | Glucose metabolism | 0.208486 | 0.681 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.306447 | 0.514 |
| R-HSA-194138 | Signaling by VEGF | 0.236595 | 0.626 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.204944 | 0.688 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.203761 | 0.691 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.293822 | 0.532 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.273152 | 0.564 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.300934 | 0.522 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.166785 | 0.778 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.150974 | 0.821 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.203761 | 0.691 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.293822 | 0.532 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.240235 | 0.619 |
| R-HSA-422475 | Axon guidance | 0.144476 | 0.840 |
| R-HSA-373753 | Nephrin family interactions | 0.259083 | 0.587 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.285292 | 0.545 |
| R-HSA-2262752 | Cellular responses to stress | 0.183252 | 0.737 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.285292 | 0.545 |
| R-HSA-9675108 | Nervous system development | 0.189584 | 0.722 |
| R-HSA-162582 | Signal Transduction | 0.288937 | 0.539 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.162854 | 0.788 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.019827 | 1.703 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.094700 | 1.024 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.262316 | 0.581 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.162294 | 0.790 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.039426 | 1.404 |
| R-HSA-449836 | Other interleukin signaling | 0.250136 | 0.602 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.117526 | 0.930 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.190927 | 0.719 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.080974 | 1.092 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.293822 | 0.532 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.231917 | 0.635 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.278671 | 0.555 |
| R-HSA-189445 | Metabolism of porphyrins | 0.244646 | 0.611 |
| R-HSA-4839726 | Chromatin organization | 0.222504 | 0.653 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.080501 | 1.094 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.275577 | 0.560 |
| R-HSA-163685 | Integration of energy metabolism | 0.278219 | 0.556 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.293822 | 0.532 |
| R-HSA-190236 | Signaling by FGFR | 0.043158 | 1.365 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.146568 | 0.834 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.241081 | 0.618 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.285292 | 0.545 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.218254 | 0.661 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.266737 | 0.574 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.310579 | 0.508 |
| R-HSA-9839394 | TGFBR3 expression | 0.310579 | 0.508 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.310579 | 0.508 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.310579 | 0.508 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.310579 | 0.508 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.318809 | 0.496 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.318809 | 0.496 |
| R-HSA-525793 | Myogenesis | 0.318809 | 0.496 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.318809 | 0.496 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.319610 | 0.495 |
| R-HSA-166520 | Signaling by NTRKs | 0.320483 | 0.494 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.326941 | 0.486 |
| R-HSA-8949613 | Cristae formation | 0.326941 | 0.486 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.326941 | 0.486 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.326941 | 0.486 |
| R-HSA-201451 | Signaling by BMP | 0.326941 | 0.486 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.326941 | 0.486 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.326941 | 0.486 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.326941 | 0.486 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.332713 | 0.478 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.332713 | 0.478 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.333526 | 0.477 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.333526 | 0.477 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.334976 | 0.475 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.340046 | 0.468 |
| R-HSA-73887 | Death Receptor Signaling | 0.340046 | 0.468 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.340046 | 0.468 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.342916 | 0.465 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.342916 | 0.465 |
| R-HSA-180024 | DARPP-32 events | 0.342916 | 0.465 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.342916 | 0.465 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.345745 | 0.461 |
| R-HSA-9610379 | HCMV Late Events | 0.349818 | 0.456 |
| R-HSA-162587 | HIV Life Cycle | 0.349818 | 0.456 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.350762 | 0.455 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.350762 | 0.455 |
| R-HSA-9711097 | Cellular response to starvation | 0.353072 | 0.452 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.358514 | 0.445 |
| R-HSA-186763 | Downstream signal transduction | 0.358514 | 0.445 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.358693 | 0.445 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.362989 | 0.440 |
| R-HSA-109581 | Apoptosis | 0.366068 | 0.436 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.366174 | 0.436 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.367275 | 0.435 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.367275 | 0.435 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.371549 | 0.430 |
| R-HSA-109582 | Hemostasis | 0.371875 | 0.430 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.372551 | 0.429 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.372551 | 0.429 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.373744 | 0.427 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.373744 | 0.427 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.375811 | 0.425 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.375811 | 0.425 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.375811 | 0.425 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.375811 | 0.425 |
| R-HSA-1640170 | Cell Cycle | 0.377194 | 0.423 |
| R-HSA-3214847 | HATs acetylate histones | 0.380062 | 0.420 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.380062 | 0.420 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.380062 | 0.420 |
| R-HSA-390522 | Striated Muscle Contraction | 0.381223 | 0.419 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.381223 | 0.419 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.381223 | 0.419 |
| R-HSA-5619102 | SLC transporter disorders | 0.382253 | 0.418 |
| R-HSA-9679506 | SARS-CoV Infections | 0.386639 | 0.413 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.388527 | 0.411 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.388613 | 0.410 |
| R-HSA-5673000 | RAF activation | 0.388613 | 0.410 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.388613 | 0.410 |
| R-HSA-190861 | Gap junction assembly | 0.388613 | 0.410 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.388613 | 0.410 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.388613 | 0.410 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.388613 | 0.410 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.392741 | 0.406 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.395916 | 0.402 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.397869 | 0.400 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.401128 | 0.397 |
| R-HSA-3371511 | HSF1 activation | 0.403132 | 0.395 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.403132 | 0.395 |
| R-HSA-8853659 | RET signaling | 0.403132 | 0.395 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.403132 | 0.395 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.407949 | 0.389 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.409462 | 0.388 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.410262 | 0.387 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.411141 | 0.386 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.413607 | 0.383 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.417307 | 0.380 |
| R-HSA-211000 | Gene Silencing by RNA | 0.417739 | 0.379 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.421855 | 0.375 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.424269 | 0.372 |
| R-HSA-71336 | Pentose phosphate pathway | 0.424269 | 0.372 |
| R-HSA-201556 | Signaling by ALK | 0.424269 | 0.372 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.424269 | 0.372 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.424269 | 0.372 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.425957 | 0.371 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.430044 | 0.366 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.430044 | 0.366 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.431148 | 0.365 |
| R-HSA-9646399 | Aggrephagy | 0.431148 | 0.365 |
| R-HSA-5260271 | Diseases of Immune System | 0.431148 | 0.365 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.431148 | 0.365 |
| R-HSA-3371568 | Attenuation phase | 0.431148 | 0.365 |
| R-HSA-8982491 | Glycogen metabolism | 0.431148 | 0.365 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.435430 | 0.361 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.436469 | 0.360 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.437945 | 0.359 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.442211 | 0.354 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.446235 | 0.350 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.450243 | 0.347 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.451298 | 0.346 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.451298 | 0.346 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.453811 | 0.343 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.454078 | 0.343 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.457855 | 0.339 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.457855 | 0.339 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.457855 | 0.339 |
| R-HSA-190828 | Gap junction trafficking | 0.464335 | 0.333 |
| R-HSA-373752 | Netrin-1 signaling | 0.464335 | 0.333 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.470035 | 0.328 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.470738 | 0.327 |
| R-HSA-774815 | Nucleosome assembly | 0.470738 | 0.327 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.470738 | 0.327 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.473943 | 0.324 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.473943 | 0.324 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.473943 | 0.324 |
| R-HSA-9609690 | HCMV Early Events | 0.476721 | 0.322 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.477064 | 0.321 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.477064 | 0.321 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.477064 | 0.321 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.477064 | 0.321 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.477064 | 0.321 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.477064 | 0.321 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.477064 | 0.321 |
| R-HSA-68875 | Mitotic Prophase | 0.477833 | 0.321 |
| R-HSA-73894 | DNA Repair | 0.479443 | 0.319 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.483315 | 0.316 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.483315 | 0.316 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.485561 | 0.314 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.485561 | 0.314 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.488844 | 0.311 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.489398 | 0.310 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.489398 | 0.310 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.489492 | 0.310 |
| R-HSA-70263 | Gluconeogenesis | 0.489492 | 0.310 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.489492 | 0.310 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.489492 | 0.310 |
| R-HSA-73893 | DNA Damage Bypass | 0.495595 | 0.305 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.495595 | 0.305 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.497846 | 0.303 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.501626 | 0.300 |
| R-HSA-5357801 | Programmed Cell Death | 0.506769 | 0.295 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.507585 | 0.294 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.507585 | 0.294 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.507993 | 0.294 |
| R-HSA-114608 | Platelet degranulation | 0.508315 | 0.294 |
| R-HSA-6798695 | Neutrophil degranulation | 0.511708 | 0.291 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.512043 | 0.291 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.513473 | 0.289 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.513473 | 0.289 |
| R-HSA-1221632 | Meiotic synapsis | 0.519292 | 0.285 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.519292 | 0.285 |
| R-HSA-72649 | Translation initiation complex formation | 0.525040 | 0.280 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.525040 | 0.280 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.525529 | 0.279 |
| R-HSA-9843745 | Adipogenesis | 0.526772 | 0.278 |
| R-HSA-9909396 | Circadian clock | 0.530407 | 0.275 |
| R-HSA-195721 | Signaling by WNT | 0.530485 | 0.275 |
| R-HSA-9753281 | Paracetamol ADME | 0.530721 | 0.275 |
| R-HSA-913531 | Interferon Signaling | 0.533309 | 0.273 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.534023 | 0.272 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.536334 | 0.271 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.536334 | 0.271 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.536334 | 0.271 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.536334 | 0.271 |
| R-HSA-5578775 | Ion homeostasis | 0.536334 | 0.271 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.536334 | 0.271 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.536334 | 0.271 |
| R-HSA-68882 | Mitotic Anaphase | 0.538768 | 0.269 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.541619 | 0.266 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.547360 | 0.262 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.547360 | 0.262 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.547360 | 0.262 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.552775 | 0.257 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.552775 | 0.257 |
| R-HSA-168249 | Innate Immune System | 0.556136 | 0.255 |
| R-HSA-156590 | Glutathione conjugation | 0.558125 | 0.253 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.558125 | 0.253 |
| R-HSA-379724 | tRNA Aminoacylation | 0.558125 | 0.253 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.558125 | 0.253 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.558803 | 0.253 |
| R-HSA-1632852 | Macroautophagy | 0.565709 | 0.247 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.568636 | 0.245 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.568636 | 0.245 |
| R-HSA-186797 | Signaling by PDGF | 0.568636 | 0.245 |
| R-HSA-162906 | HIV Infection | 0.569561 | 0.244 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.578898 | 0.237 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.583937 | 0.234 |
| R-HSA-1266738 | Developmental Biology | 0.584105 | 0.234 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.588917 | 0.230 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.592558 | 0.227 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.593837 | 0.226 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.596438 | 0.224 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.598699 | 0.223 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.599075 | 0.223 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.599075 | 0.223 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.608249 | 0.216 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.608249 | 0.216 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.612939 | 0.213 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.617573 | 0.209 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.617573 | 0.209 |
| R-HSA-9612973 | Autophagy | 0.618157 | 0.209 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.622152 | 0.206 |
| R-HSA-4086398 | Ca2+ pathway | 0.622152 | 0.206 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.622152 | 0.206 |
| R-HSA-9749641 | Aspirin ADME | 0.622152 | 0.206 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.624361 | 0.205 |
| R-HSA-877300 | Interferon gamma signaling | 0.627435 | 0.202 |
| R-HSA-9609646 | HCMV Infection | 0.629720 | 0.201 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.631147 | 0.200 |
| R-HSA-917937 | Iron uptake and transport | 0.631147 | 0.200 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.635564 | 0.197 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.644241 | 0.191 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.644241 | 0.191 |
| R-HSA-5619084 | ABC transporter disorders | 0.644241 | 0.191 |
| R-HSA-216083 | Integrin cell surface interactions | 0.644241 | 0.191 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.648502 | 0.188 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.649245 | 0.188 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.652713 | 0.185 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.652713 | 0.185 |
| R-HSA-9833482 | PKR-mediated signaling | 0.652713 | 0.185 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.656873 | 0.183 |
| R-HSA-977225 | Amyloid fiber formation | 0.656873 | 0.183 |
| R-HSA-449147 | Signaling by Interleukins | 0.658823 | 0.181 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.661074 | 0.180 |
| R-HSA-72306 | tRNA processing | 0.662805 | 0.179 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.665628 | 0.177 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.669058 | 0.175 |
| R-HSA-1500620 | Meiosis | 0.673024 | 0.172 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.677286 | 0.169 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.686082 | 0.164 |
| R-HSA-9663891 | Selective autophagy | 0.688418 | 0.162 |
| R-HSA-2559583 | Cellular Senescence | 0.690187 | 0.161 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.692153 | 0.160 |
| R-HSA-202424 | Downstream TCR signaling | 0.695843 | 0.157 |
| R-HSA-9658195 | Leishmania infection | 0.701270 | 0.154 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.701270 | 0.154 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.706651 | 0.151 |
| R-HSA-983712 | Ion channel transport | 0.713251 | 0.147 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.713644 | 0.147 |
| R-HSA-5617833 | Cilium Assembly | 0.715724 | 0.145 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.720470 | 0.142 |
| R-HSA-9824446 | Viral Infection Pathways | 0.728201 | 0.138 |
| R-HSA-422356 | Regulation of insulin secretion | 0.730408 | 0.136 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.736836 | 0.133 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.739993 | 0.131 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.743113 | 0.129 |
| R-HSA-1483255 | PI Metabolism | 0.743113 | 0.129 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.746269 | 0.127 |
| R-HSA-111885 | Opioid Signalling | 0.749240 | 0.125 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.755222 | 0.122 |
| R-HSA-418346 | Platelet homeostasis | 0.758160 | 0.120 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.761062 | 0.119 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.761062 | 0.119 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.763930 | 0.117 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.767985 | 0.115 |
| R-HSA-202403 | TCR signaling | 0.769563 | 0.114 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.769887 | 0.114 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.775801 | 0.110 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.777763 | 0.109 |
| R-HSA-9748784 | Drug ADME | 0.779979 | 0.108 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.781056 | 0.107 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.785673 | 0.105 |
| R-HSA-8951664 | Neddylation | 0.785847 | 0.105 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.788247 | 0.103 |
| R-HSA-72766 | Translation | 0.789948 | 0.102 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.793303 | 0.101 |
| R-HSA-73886 | Chromosome Maintenance | 0.803057 | 0.095 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.807761 | 0.093 |
| R-HSA-199991 | Membrane Trafficking | 0.816226 | 0.088 |
| R-HSA-5663205 | Infectious disease | 0.825307 | 0.083 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.825485 | 0.083 |
| R-HSA-1474165 | Reproduction | 0.827583 | 0.082 |
| R-HSA-5576891 | Cardiac conduction | 0.829656 | 0.081 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.831704 | 0.080 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.841583 | 0.075 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.843488 | 0.074 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.844773 | 0.073 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.856203 | 0.067 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.857933 | 0.067 |
| R-HSA-2187338 | Visual phototransduction | 0.863001 | 0.064 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.864721 | 0.063 |
| R-HSA-9758941 | Gastrulation | 0.866280 | 0.062 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.867889 | 0.062 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.871051 | 0.060 |
| R-HSA-2142753 | Arachidonate metabolism | 0.871051 | 0.060 |
| R-HSA-69306 | DNA Replication | 0.872604 | 0.059 |
| R-HSA-9609507 | Protein localization | 0.872604 | 0.059 |
| R-HSA-168256 | Immune System | 0.873523 | 0.059 |
| R-HSA-556833 | Metabolism of lipids | 0.873966 | 0.059 |
| R-HSA-74160 | Gene expression (Transcription) | 0.881594 | 0.055 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.882964 | 0.054 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.886938 | 0.052 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.892866 | 0.049 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.900030 | 0.046 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.901235 | 0.045 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.901235 | 0.045 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.901235 | 0.045 |
| R-HSA-1500931 | Cell-Cell communication | 0.912657 | 0.040 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.918459 | 0.037 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.921576 | 0.035 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.925295 | 0.034 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.928838 | 0.032 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.932438 | 0.030 |
| R-HSA-418990 | Adherens junctions interactions | 0.943516 | 0.025 |
| R-HSA-212436 | Generic Transcription Pathway | 0.944732 | 0.025 |
| R-HSA-1280218 | Adaptive Immune System | 0.945675 | 0.024 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.945800 | 0.024 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.950000 | 0.022 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.951191 | 0.022 |
| R-HSA-1430728 | Metabolism | 0.951939 | 0.021 |
| R-HSA-15869 | Metabolism of nucleotides | 0.954630 | 0.020 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.956258 | 0.019 |
| R-HSA-157118 | Signaling by NOTCH | 0.956787 | 0.019 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.958789 | 0.018 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.961637 | 0.017 |
| R-HSA-421270 | Cell-cell junction organization | 0.962208 | 0.017 |
| R-HSA-5688426 | Deubiquitination | 0.964007 | 0.016 |
| R-HSA-8978868 | Fatty acid metabolism | 0.965382 | 0.015 |
| R-HSA-1643685 | Disease | 0.970351 | 0.013 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.972815 | 0.012 |
| R-HSA-446728 | Cell junction organization | 0.972815 | 0.012 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.974111 | 0.011 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.976001 | 0.011 |
| R-HSA-1483257 | Phospholipid metabolism | 0.977914 | 0.010 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.981085 | 0.008 |
| R-HSA-112316 | Neuronal System | 0.981674 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 0.982481 | 0.008 |
| R-HSA-1474244 | Extracellular matrix organization | 0.985784 | 0.006 |
| R-HSA-211859 | Biological oxidations | 0.989799 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.994479 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.996520 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.996812 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998527 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.999695 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999977 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.876 | 0.164 | 2 | 0.846 |
CDC7 |
0.872 | 0.151 | 1 | 0.868 |
PIM3 |
0.866 | 0.162 | -3 | 0.882 |
MOS |
0.865 | 0.155 | 1 | 0.903 |
PRKD1 |
0.864 | 0.197 | -3 | 0.853 |
NDR2 |
0.864 | 0.112 | -3 | 0.877 |
CDKL5 |
0.864 | 0.203 | -3 | 0.853 |
CDKL1 |
0.862 | 0.180 | -3 | 0.863 |
CAMK1B |
0.862 | 0.143 | -3 | 0.895 |
ERK5 |
0.861 | 0.155 | 1 | 0.837 |
PRPK |
0.861 | -0.054 | -1 | 0.808 |
RSK2 |
0.861 | 0.182 | -3 | 0.828 |
CLK3 |
0.861 | 0.176 | 1 | 0.829 |
NUAK2 |
0.861 | 0.161 | -3 | 0.871 |
HIPK4 |
0.861 | 0.182 | 1 | 0.810 |
P90RSK |
0.860 | 0.169 | -3 | 0.835 |
SRPK1 |
0.859 | 0.193 | -3 | 0.815 |
NDR1 |
0.859 | 0.121 | -3 | 0.872 |
RAF1 |
0.859 | -0.021 | 1 | 0.826 |
FAM20C |
0.858 | 0.242 | 2 | 0.665 |
PRKD2 |
0.858 | 0.184 | -3 | 0.812 |
PKN3 |
0.858 | 0.117 | -3 | 0.866 |
NLK |
0.858 | 0.082 | 1 | 0.837 |
PDHK1 |
0.858 | -0.048 | 1 | 0.827 |
PDHK4 |
0.858 | -0.140 | 1 | 0.845 |
MTOR |
0.858 | -0.046 | 1 | 0.796 |
DSTYK |
0.858 | 0.016 | 2 | 0.846 |
PIM1 |
0.858 | 0.198 | -3 | 0.838 |
KIS |
0.857 | 0.107 | 1 | 0.722 |
TBK1 |
0.857 | -0.049 | 1 | 0.716 |
AMPKA1 |
0.857 | 0.144 | -3 | 0.874 |
MAPKAPK3 |
0.856 | 0.154 | -3 | 0.821 |
SKMLCK |
0.856 | 0.128 | -2 | 0.851 |
IKKB |
0.856 | -0.071 | -2 | 0.781 |
MARK4 |
0.856 | 0.093 | 4 | 0.831 |
GCN2 |
0.856 | -0.129 | 2 | 0.764 |
MAPKAPK2 |
0.856 | 0.193 | -3 | 0.795 |
TSSK2 |
0.855 | 0.175 | -5 | 0.867 |
ULK2 |
0.855 | -0.100 | 2 | 0.772 |
RSK3 |
0.854 | 0.137 | -3 | 0.828 |
BMPR2 |
0.854 | -0.088 | -2 | 0.884 |
ATR |
0.854 | -0.002 | 1 | 0.820 |
ICK |
0.854 | 0.155 | -3 | 0.885 |
TSSK1 |
0.854 | 0.161 | -3 | 0.883 |
CAMLCK |
0.854 | 0.100 | -2 | 0.840 |
AMPKA2 |
0.853 | 0.151 | -3 | 0.851 |
WNK1 |
0.853 | 0.054 | -2 | 0.869 |
CAMK2D |
0.853 | 0.092 | -3 | 0.864 |
BCKDK |
0.853 | -0.015 | -1 | 0.828 |
RIPK3 |
0.853 | 0.013 | 3 | 0.800 |
NIK |
0.853 | 0.074 | -3 | 0.898 |
CAMK2G |
0.852 | -0.055 | 2 | 0.778 |
IKKE |
0.852 | -0.087 | 1 | 0.706 |
TGFBR2 |
0.852 | -0.013 | -2 | 0.784 |
PKCD |
0.851 | 0.107 | 2 | 0.759 |
LATS2 |
0.851 | 0.064 | -5 | 0.746 |
DAPK2 |
0.851 | 0.099 | -3 | 0.895 |
NEK6 |
0.851 | -0.029 | -2 | 0.871 |
SRPK2 |
0.850 | 0.176 | -3 | 0.754 |
P70S6KB |
0.850 | 0.118 | -3 | 0.846 |
MST4 |
0.850 | 0.040 | 2 | 0.811 |
NIM1 |
0.850 | 0.079 | 3 | 0.809 |
NUAK1 |
0.850 | 0.110 | -3 | 0.838 |
DYRK2 |
0.849 | 0.161 | 1 | 0.741 |
PKN2 |
0.849 | 0.068 | -3 | 0.858 |
GRK5 |
0.848 | -0.097 | -3 | 0.864 |
CAMK2B |
0.848 | 0.145 | 2 | 0.758 |
GRK6 |
0.848 | 0.046 | 1 | 0.829 |
LATS1 |
0.847 | 0.182 | -3 | 0.894 |
PRKD3 |
0.847 | 0.161 | -3 | 0.793 |
MELK |
0.847 | 0.121 | -3 | 0.832 |
NEK7 |
0.847 | -0.133 | -3 | 0.845 |
PKACG |
0.846 | 0.066 | -2 | 0.724 |
HUNK |
0.846 | -0.070 | 2 | 0.763 |
ATM |
0.846 | 0.042 | 1 | 0.759 |
SRPK3 |
0.846 | 0.150 | -3 | 0.798 |
AURC |
0.845 | 0.080 | -2 | 0.637 |
NEK9 |
0.845 | -0.068 | 2 | 0.812 |
QSK |
0.844 | 0.099 | 4 | 0.808 |
SIK |
0.844 | 0.124 | -3 | 0.814 |
MLK1 |
0.844 | -0.112 | 2 | 0.780 |
WNK3 |
0.844 | -0.149 | 1 | 0.794 |
MSK2 |
0.843 | 0.085 | -3 | 0.812 |
IKKA |
0.843 | -0.027 | -2 | 0.776 |
CAMK2A |
0.843 | 0.119 | 2 | 0.746 |
CDK7 |
0.843 | 0.076 | 1 | 0.695 |
CDK8 |
0.843 | 0.056 | 1 | 0.669 |
CAMK4 |
0.843 | 0.018 | -3 | 0.849 |
MASTL |
0.843 | -0.179 | -2 | 0.821 |
RIPK1 |
0.843 | -0.063 | 1 | 0.810 |
ULK1 |
0.842 | -0.170 | -3 | 0.830 |
CHAK2 |
0.842 | -0.078 | -1 | 0.754 |
CHK1 |
0.842 | 0.128 | -3 | 0.866 |
RSK4 |
0.842 | 0.150 | -3 | 0.805 |
QIK |
0.842 | 0.042 | -3 | 0.854 |
IRE1 |
0.841 | -0.020 | 1 | 0.792 |
MNK2 |
0.841 | 0.033 | -2 | 0.788 |
ANKRD3 |
0.841 | -0.065 | 1 | 0.837 |
HIPK1 |
0.841 | 0.186 | 1 | 0.753 |
BMPR1B |
0.840 | 0.101 | 1 | 0.800 |
IRE2 |
0.840 | 0.018 | 2 | 0.747 |
PAK1 |
0.840 | 0.028 | -2 | 0.768 |
CLK4 |
0.840 | 0.129 | -3 | 0.820 |
JNK2 |
0.839 | 0.140 | 1 | 0.647 |
CLK1 |
0.839 | 0.150 | -3 | 0.794 |
PKCA |
0.839 | 0.068 | 2 | 0.700 |
CDK18 |
0.839 | 0.120 | 1 | 0.633 |
PIM2 |
0.839 | 0.165 | -3 | 0.803 |
SGK3 |
0.839 | 0.139 | -3 | 0.804 |
BRSK1 |
0.839 | 0.080 | -3 | 0.833 |
PAK3 |
0.839 | -0.007 | -2 | 0.771 |
PKCB |
0.839 | 0.066 | 2 | 0.705 |
PKACB |
0.839 | 0.126 | -2 | 0.660 |
MLK2 |
0.839 | -0.077 | 2 | 0.792 |
GRK1 |
0.838 | -0.020 | -2 | 0.753 |
DYRK1A |
0.838 | 0.158 | 1 | 0.758 |
GRK4 |
0.838 | -0.113 | -2 | 0.810 |
CDK19 |
0.838 | 0.058 | 1 | 0.634 |
MSK1 |
0.838 | 0.097 | -3 | 0.814 |
PLK1 |
0.838 | -0.012 | -2 | 0.827 |
TGFBR1 |
0.838 | 0.027 | -2 | 0.778 |
CDK5 |
0.838 | 0.104 | 1 | 0.710 |
PKR |
0.838 | 0.050 | 1 | 0.837 |
AURB |
0.837 | 0.055 | -2 | 0.635 |
AKT2 |
0.837 | 0.151 | -3 | 0.752 |
ALK4 |
0.837 | -0.025 | -2 | 0.805 |
P38A |
0.837 | 0.107 | 1 | 0.735 |
MARK3 |
0.837 | 0.074 | 4 | 0.764 |
PHKG1 |
0.837 | 0.017 | -3 | 0.855 |
MARK2 |
0.836 | 0.064 | 4 | 0.729 |
HIPK2 |
0.836 | 0.157 | 1 | 0.657 |
JNK3 |
0.836 | 0.110 | 1 | 0.682 |
PKCG |
0.836 | 0.030 | 2 | 0.696 |
DNAPK |
0.836 | 0.053 | 1 | 0.698 |
DLK |
0.836 | -0.160 | 1 | 0.805 |
MAPKAPK5 |
0.835 | 0.043 | -3 | 0.781 |
PKG2 |
0.835 | 0.070 | -2 | 0.661 |
MYLK4 |
0.835 | 0.062 | -2 | 0.762 |
MNK1 |
0.835 | 0.033 | -2 | 0.799 |
TTBK2 |
0.834 | -0.178 | 2 | 0.670 |
BRSK2 |
0.834 | 0.009 | -3 | 0.840 |
MLK3 |
0.834 | -0.043 | 2 | 0.704 |
ACVR2A |
0.833 | 0.018 | -2 | 0.794 |
HIPK3 |
0.833 | 0.141 | 1 | 0.749 |
CDK13 |
0.833 | 0.037 | 1 | 0.674 |
P38B |
0.833 | 0.106 | 1 | 0.674 |
MARK1 |
0.833 | 0.062 | 4 | 0.788 |
PAK2 |
0.833 | -0.014 | -2 | 0.752 |
PRKX |
0.832 | 0.141 | -3 | 0.734 |
PAK6 |
0.832 | 0.021 | -2 | 0.698 |
GRK7 |
0.832 | 0.040 | 1 | 0.770 |
CLK2 |
0.832 | 0.180 | -3 | 0.805 |
PLK3 |
0.832 | -0.008 | 2 | 0.726 |
PKCH |
0.832 | 0.007 | 2 | 0.696 |
MEK1 |
0.832 | -0.117 | 2 | 0.803 |
VRK2 |
0.832 | -0.122 | 1 | 0.863 |
CAMK1G |
0.831 | 0.085 | -3 | 0.812 |
CDK1 |
0.831 | 0.073 | 1 | 0.658 |
DYRK1B |
0.831 | 0.145 | 1 | 0.685 |
DCAMKL1 |
0.831 | 0.096 | -3 | 0.820 |
CDK17 |
0.831 | 0.087 | 1 | 0.584 |
P38G |
0.831 | 0.097 | 1 | 0.577 |
ACVR2B |
0.831 | 0.014 | -2 | 0.805 |
PKCZ |
0.830 | -0.020 | 2 | 0.759 |
ALK2 |
0.830 | 0.023 | -2 | 0.778 |
YSK4 |
0.830 | -0.098 | 1 | 0.752 |
NEK2 |
0.830 | -0.093 | 2 | 0.788 |
ERK1 |
0.830 | 0.070 | 1 | 0.660 |
DYRK3 |
0.829 | 0.150 | 1 | 0.761 |
MLK4 |
0.829 | -0.055 | 2 | 0.695 |
CDK14 |
0.829 | 0.119 | 1 | 0.674 |
SNRK |
0.829 | -0.084 | 2 | 0.667 |
AKT1 |
0.829 | 0.141 | -3 | 0.761 |
DYRK4 |
0.828 | 0.129 | 1 | 0.665 |
CAMK1D |
0.828 | 0.151 | -3 | 0.742 |
SSTK |
0.828 | 0.077 | 4 | 0.803 |
HRI |
0.828 | -0.088 | -2 | 0.863 |
BRAF |
0.828 | 0.020 | -4 | 0.845 |
SMG1 |
0.828 | -0.075 | 1 | 0.771 |
AURA |
0.827 | 0.018 | -2 | 0.603 |
P70S6K |
0.827 | 0.089 | -3 | 0.773 |
ERK2 |
0.827 | 0.043 | 1 | 0.698 |
CDK16 |
0.827 | 0.127 | 1 | 0.601 |
PKACA |
0.827 | 0.107 | -2 | 0.612 |
CDK9 |
0.827 | 0.026 | 1 | 0.682 |
CDK12 |
0.827 | 0.040 | 1 | 0.647 |
CDK2 |
0.827 | 0.026 | 1 | 0.733 |
PERK |
0.827 | -0.082 | -2 | 0.836 |
WNK4 |
0.826 | -0.023 | -2 | 0.854 |
SMMLCK |
0.826 | 0.073 | -3 | 0.857 |
IRAK4 |
0.825 | -0.020 | 1 | 0.789 |
CHAK1 |
0.825 | -0.148 | 2 | 0.755 |
TLK2 |
0.825 | -0.101 | 1 | 0.755 |
BMPR1A |
0.825 | 0.072 | 1 | 0.780 |
PLK4 |
0.824 | -0.079 | 2 | 0.613 |
PKCT |
0.824 | 0.033 | 2 | 0.710 |
CDK3 |
0.824 | 0.093 | 1 | 0.603 |
MEKK1 |
0.823 | -0.082 | 1 | 0.782 |
PHKG2 |
0.823 | 0.015 | -3 | 0.820 |
MEKK2 |
0.822 | -0.048 | 2 | 0.779 |
MAK |
0.822 | 0.213 | -2 | 0.743 |
NEK5 |
0.822 | -0.050 | 1 | 0.809 |
DRAK1 |
0.822 | -0.077 | 1 | 0.761 |
MPSK1 |
0.822 | 0.071 | 1 | 0.783 |
DCAMKL2 |
0.821 | 0.019 | -3 | 0.840 |
P38D |
0.821 | 0.106 | 1 | 0.596 |
CDK10 |
0.821 | 0.110 | 1 | 0.662 |
MOK |
0.821 | 0.229 | 1 | 0.785 |
ZAK |
0.821 | -0.101 | 1 | 0.751 |
MEK5 |
0.820 | -0.192 | 2 | 0.793 |
PRP4 |
0.820 | -0.004 | -3 | 0.739 |
PINK1 |
0.820 | -0.141 | 1 | 0.820 |
AKT3 |
0.820 | 0.161 | -3 | 0.697 |
GRK2 |
0.820 | -0.068 | -2 | 0.705 |
DAPK3 |
0.820 | 0.115 | -3 | 0.843 |
TLK1 |
0.820 | -0.075 | -2 | 0.830 |
SGK1 |
0.819 | 0.166 | -3 | 0.687 |
PKN1 |
0.818 | 0.094 | -3 | 0.775 |
CAMK1A |
0.817 | 0.149 | -3 | 0.718 |
MEKK3 |
0.817 | -0.167 | 1 | 0.784 |
PKCI |
0.817 | 0.006 | 2 | 0.724 |
SBK |
0.817 | 0.189 | -3 | 0.646 |
PASK |
0.816 | 0.022 | -3 | 0.891 |
CK2A2 |
0.816 | 0.126 | 1 | 0.767 |
ERK7 |
0.816 | 0.051 | 2 | 0.536 |
MST3 |
0.816 | -0.036 | 2 | 0.784 |
IRAK1 |
0.815 | -0.155 | -1 | 0.706 |
PAK5 |
0.814 | -0.017 | -2 | 0.628 |
PKCE |
0.814 | 0.055 | 2 | 0.684 |
CHK2 |
0.814 | 0.124 | -3 | 0.697 |
TAO3 |
0.813 | -0.062 | 1 | 0.779 |
PDK1 |
0.813 | -0.009 | 1 | 0.793 |
NEK8 |
0.812 | -0.116 | 2 | 0.789 |
MRCKB |
0.812 | 0.116 | -3 | 0.787 |
LKB1 |
0.811 | -0.017 | -3 | 0.821 |
MRCKA |
0.811 | 0.114 | -3 | 0.805 |
GSK3A |
0.811 | 0.010 | 4 | 0.441 |
CAMKK1 |
0.811 | -0.088 | -2 | 0.796 |
JNK1 |
0.811 | 0.067 | 1 | 0.638 |
PAK4 |
0.811 | -0.012 | -2 | 0.632 |
ROCK2 |
0.811 | 0.136 | -3 | 0.826 |
DAPK1 |
0.810 | 0.076 | -3 | 0.830 |
CK1E |
0.810 | -0.068 | -3 | 0.553 |
GSK3B |
0.810 | -0.036 | 4 | 0.434 |
TAO2 |
0.810 | -0.079 | 2 | 0.818 |
NEK4 |
0.810 | -0.061 | 1 | 0.771 |
CAMKK2 |
0.809 | -0.064 | -2 | 0.796 |
TTBK1 |
0.809 | -0.188 | 2 | 0.587 |
EEF2K |
0.809 | -0.009 | 3 | 0.807 |
CDK6 |
0.809 | 0.061 | 1 | 0.653 |
GAK |
0.809 | -0.018 | 1 | 0.840 |
CDK4 |
0.809 | 0.067 | 1 | 0.635 |
MST2 |
0.809 | -0.033 | 1 | 0.782 |
HGK |
0.807 | -0.025 | 3 | 0.834 |
TNIK |
0.806 | 0.011 | 3 | 0.833 |
PLK2 |
0.806 | 0.027 | -3 | 0.855 |
NEK1 |
0.806 | -0.023 | 1 | 0.788 |
GRK3 |
0.805 | -0.070 | -2 | 0.648 |
MINK |
0.805 | -0.039 | 1 | 0.761 |
CK1G1 |
0.805 | -0.091 | -3 | 0.560 |
BUB1 |
0.805 | 0.098 | -5 | 0.794 |
GCK |
0.804 | -0.053 | 1 | 0.770 |
DMPK1 |
0.804 | 0.151 | -3 | 0.800 |
LRRK2 |
0.804 | -0.097 | 2 | 0.816 |
MEKK6 |
0.804 | -0.086 | 1 | 0.762 |
MAP3K15 |
0.804 | -0.078 | 1 | 0.741 |
CK2A1 |
0.804 | 0.085 | 1 | 0.746 |
NEK11 |
0.803 | -0.220 | 1 | 0.771 |
VRK1 |
0.803 | -0.097 | 2 | 0.827 |
LOK |
0.802 | -0.060 | -2 | 0.781 |
PBK |
0.802 | 0.042 | 1 | 0.770 |
CK1D |
0.801 | -0.070 | -3 | 0.499 |
KHS1 |
0.800 | 0.008 | 1 | 0.757 |
HPK1 |
0.799 | -0.059 | 1 | 0.763 |
MEK2 |
0.798 | -0.180 | 2 | 0.790 |
CK1A2 |
0.798 | -0.076 | -3 | 0.500 |
RIPK2 |
0.798 | -0.198 | 1 | 0.720 |
CRIK |
0.798 | 0.128 | -3 | 0.767 |
KHS2 |
0.798 | 0.019 | 1 | 0.765 |
TTK |
0.797 | 0.066 | -2 | 0.829 |
YSK1 |
0.797 | -0.056 | 2 | 0.780 |
ROCK1 |
0.797 | 0.105 | -3 | 0.797 |
PKG1 |
0.797 | 0.025 | -2 | 0.568 |
TAK1 |
0.796 | -0.173 | 1 | 0.780 |
MST1 |
0.796 | -0.109 | 1 | 0.765 |
PDHK3_TYR |
0.795 | 0.200 | 4 | 0.888 |
NEK3 |
0.794 | -0.106 | 1 | 0.737 |
STK33 |
0.791 | -0.189 | 2 | 0.569 |
SLK |
0.790 | -0.145 | -2 | 0.728 |
HASPIN |
0.789 | -0.021 | -1 | 0.611 |
BIKE |
0.788 | 0.049 | 1 | 0.730 |
TESK1_TYR |
0.787 | 0.023 | 3 | 0.863 |
MYO3B |
0.786 | -0.027 | 2 | 0.793 |
MAP2K4_TYR |
0.786 | 0.021 | -1 | 0.843 |
PKMYT1_TYR |
0.785 | 0.002 | 3 | 0.863 |
OSR1 |
0.785 | -0.085 | 2 | 0.770 |
PDHK4_TYR |
0.783 | 0.006 | 2 | 0.833 |
ALPHAK3 |
0.782 | -0.020 | -1 | 0.717 |
LIMK2_TYR |
0.782 | 0.035 | -3 | 0.886 |
MAP2K6_TYR |
0.782 | -0.029 | -1 | 0.836 |
ASK1 |
0.781 | -0.136 | 1 | 0.733 |
EPHB4 |
0.781 | 0.099 | -1 | 0.819 |
EPHA6 |
0.780 | 0.086 | -1 | 0.812 |
MYO3A |
0.780 | -0.078 | 1 | 0.768 |
MAP2K7_TYR |
0.779 | -0.216 | 2 | 0.821 |
PINK1_TYR |
0.779 | -0.134 | 1 | 0.838 |
PDHK1_TYR |
0.779 | -0.062 | -1 | 0.837 |
TAO1 |
0.778 | -0.114 | 1 | 0.705 |
BMPR2_TYR |
0.778 | -0.040 | -1 | 0.810 |
RET |
0.777 | -0.029 | 1 | 0.789 |
YES1 |
0.777 | 0.076 | -1 | 0.791 |
ROS1 |
0.777 | 0.002 | 3 | 0.805 |
LIMK1_TYR |
0.775 | -0.109 | 2 | 0.832 |
MST1R |
0.775 | -0.047 | 3 | 0.827 |
TYK2 |
0.775 | -0.085 | 1 | 0.783 |
AAK1 |
0.775 | 0.090 | 1 | 0.633 |
TNNI3K_TYR |
0.775 | 0.076 | 1 | 0.796 |
TYRO3 |
0.774 | -0.056 | 3 | 0.817 |
DDR1 |
0.773 | -0.048 | 4 | 0.799 |
CSF1R |
0.773 | -0.018 | 3 | 0.834 |
FGR |
0.773 | -0.009 | 1 | 0.838 |
JAK2 |
0.772 | -0.078 | 1 | 0.776 |
ABL2 |
0.772 | 0.024 | -1 | 0.755 |
INSRR |
0.771 | 0.018 | 3 | 0.784 |
TXK |
0.771 | 0.081 | 1 | 0.836 |
TNK2 |
0.770 | 0.018 | 3 | 0.779 |
YANK3 |
0.770 | -0.115 | 2 | 0.350 |
EPHB1 |
0.769 | 0.017 | 1 | 0.830 |
EPHB2 |
0.769 | 0.054 | -1 | 0.802 |
EPHB3 |
0.769 | 0.028 | -1 | 0.805 |
JAK3 |
0.769 | -0.032 | 1 | 0.770 |
HCK |
0.769 | -0.012 | -1 | 0.756 |
STLK3 |
0.768 | -0.182 | 1 | 0.719 |
ABL1 |
0.768 | 0.003 | -1 | 0.754 |
BLK |
0.768 | 0.082 | -1 | 0.761 |
LCK |
0.768 | 0.034 | -1 | 0.750 |
FER |
0.767 | -0.090 | 1 | 0.856 |
PDGFRB |
0.767 | -0.074 | 3 | 0.826 |
TNK1 |
0.766 | -0.034 | 3 | 0.810 |
EPHA4 |
0.766 | -0.021 | 2 | 0.716 |
SRMS |
0.766 | -0.032 | 1 | 0.839 |
FGFR2 |
0.765 | -0.052 | 3 | 0.819 |
JAK1 |
0.765 | -0.021 | 1 | 0.725 |
KDR |
0.764 | -0.019 | 3 | 0.806 |
AXL |
0.764 | -0.043 | 3 | 0.813 |
FGFR1 |
0.763 | -0.060 | 3 | 0.799 |
KIT |
0.763 | -0.085 | 3 | 0.836 |
FLT3 |
0.763 | -0.089 | 3 | 0.822 |
LTK |
0.763 | -0.029 | 3 | 0.778 |
ITK |
0.762 | -0.052 | -1 | 0.735 |
DDR2 |
0.762 | 0.072 | 3 | 0.764 |
MERTK |
0.762 | -0.028 | 3 | 0.814 |
TEK |
0.761 | -0.097 | 3 | 0.784 |
FYN |
0.761 | 0.039 | -1 | 0.725 |
ALK |
0.761 | -0.066 | 3 | 0.747 |
PDGFRA |
0.761 | -0.123 | 3 | 0.827 |
NEK10_TYR |
0.761 | -0.099 | 1 | 0.660 |
TEC |
0.760 | -0.040 | -1 | 0.695 |
EPHA7 |
0.760 | -0.012 | 2 | 0.725 |
CK1A |
0.759 | -0.116 | -3 | 0.410 |
NTRK1 |
0.758 | -0.092 | -1 | 0.800 |
BMX |
0.758 | -0.057 | -1 | 0.644 |
LYN |
0.758 | -0.004 | 3 | 0.785 |
EPHA3 |
0.757 | -0.059 | 2 | 0.695 |
NTRK2 |
0.757 | -0.085 | 3 | 0.802 |
EPHA1 |
0.756 | -0.054 | 3 | 0.788 |
BTK |
0.756 | -0.151 | -1 | 0.700 |
INSR |
0.756 | -0.066 | 3 | 0.766 |
MET |
0.755 | -0.108 | 3 | 0.799 |
FLT4 |
0.754 | -0.078 | 3 | 0.815 |
PTK2B |
0.754 | -0.023 | -1 | 0.747 |
PTK6 |
0.753 | -0.187 | -1 | 0.685 |
WEE1_TYR |
0.753 | -0.114 | -1 | 0.690 |
EPHA5 |
0.753 | 0.000 | 2 | 0.707 |
SRC |
0.753 | -0.003 | -1 | 0.741 |
NTRK3 |
0.752 | -0.090 | -1 | 0.752 |
FGFR3 |
0.752 | -0.107 | 3 | 0.798 |
FRK |
0.751 | -0.090 | -1 | 0.767 |
FLT1 |
0.751 | -0.094 | -1 | 0.789 |
ERBB2 |
0.751 | -0.145 | 1 | 0.744 |
EPHA8 |
0.748 | -0.066 | -1 | 0.756 |
EGFR |
0.743 | -0.076 | 1 | 0.655 |
FGFR4 |
0.742 | -0.093 | -1 | 0.739 |
CSK |
0.742 | -0.154 | 2 | 0.729 |
PTK2 |
0.741 | -0.019 | -1 | 0.732 |
MATK |
0.740 | -0.163 | -1 | 0.681 |
CK1G3 |
0.740 | -0.114 | -3 | 0.363 |
IGF1R |
0.740 | -0.098 | 3 | 0.719 |
EPHA2 |
0.736 | -0.078 | -1 | 0.727 |
MUSK |
0.734 | -0.156 | 1 | 0.650 |
YANK2 |
0.733 | -0.150 | 2 | 0.369 |
SYK |
0.732 | -0.078 | -1 | 0.709 |
ERBB4 |
0.730 | -0.082 | 1 | 0.673 |
FES |
0.721 | -0.165 | -1 | 0.642 |
CK1G2 |
0.711 | -0.161 | -3 | 0.466 |
ZAP70 |
0.705 | -0.138 | -1 | 0.622 |