Motif 96 (n=129)

Position-wise Probabilities
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uniprot genes site source protein function
A4UGR9 XIRP2 S2348 ochoa Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}.
A7KAX9 ARHGAP32 S952 ochoa Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.
O00159 MYO1C S592 ochoa Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}.
O14531 DPYSL4 S542 ochoa Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.
O43303 CCP110 S551 ochoa Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}.
O43670 ZNF207 S346 ochoa BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187, ECO:0000269|PubMed:26388440}.
O95789 ZMYM6 S397 ochoa Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
O95985 TOP3B S788 ochoa DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1) Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. {ECO:0000250}.
P04004 VTN S312 ochoa|psp Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
P07384 CAPN1 S93 ochoa Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}.
P11055 MYH3 S174 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P12882 MYH1 S174 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S19 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 S173 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S173 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 S176 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P15172 MYOD1 S278 psp Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3) Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). {ECO:0000250}.
P15735 PHKG2 S269 ochoa Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}.
P15822 HIVEP1 S670 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P15884 TCF4 S198 ochoa Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}.
P15924 DSP S2526 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P21802 FGFR2 S452 ochoa Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.
P25054 APC S1238 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P30414 NKTR S1200 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P31629 HIVEP2 S565 ochoa Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
P32322 PYCR1 S109 ochoa Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921). {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921, ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:28258219}.
P32519 ELF1 S542 ochoa ETS-related transcription factor Elf-1 (E74-like factor 1) Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}.
P33993 MCM7 S483 ochoa DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
P35269 GTF2F1 S396 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P46087 NOP2 S594 ochoa 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
P46821 MAP1B S1501 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P49327 FASN S2123 ochoa Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
P49790 NUP153 S1046 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P52179 MYOM1 S220 ochoa Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P52594 AGFG1 S292 ochoa Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}.
P53814 SMTN S690 ochoa Smoothelin Structural protein of the cytoskeleton.
P78369 CLDN10 S199 ochoa Claudin-10 (Oligodendrocyte-specific protein-like) (OSP-like) Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}.; FUNCTION: [Isoform 1]: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28686597, PubMed:28771254, PubMed:35650657, PubMed:36008380). {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}.; FUNCTION: [Isoform 2]: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis. {ECO:0000250|UniProtKB:Q9Z0S6, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:36008380}.
P78527 PRKDC S2041 psp DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
Q02241 KIF23 S160 ochoa Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}.
Q03164 KMT2A S3216 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04864 REL S492 psp Proto-oncogene c-Rel Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Q04864 REL S557 psp Proto-oncogene c-Rel Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Q12955 ANK3 S539 ochoa Ankyrin-3 (ANK-3) (Ankyrin-G) Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.
Q13009 TIAM1 S370 ochoa Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}.
Q13309 SKP2 S256 psp S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}.
Q13426 XRCC4 S259 ochoa DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}.
Q14157 UBAP2L S340 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14207 NPAT S1151 ochoa Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
Q15700 DLG2 S65 ochoa Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.
Q5JWR5 DOP1A S1267 ochoa Protein DOP1A May be involved in protein traffic between late Golgi and early endosomes. {ECO:0000250|UniProtKB:Q03921}.
Q5SVZ6 ZMYM1 S387 ochoa Zinc finger MYM-type protein 1 None
Q5T1R4 HIVEP3 S1437 ochoa Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}.
Q5T5P2 KIAA1217 S610 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5T5P2 KIAA1217 S1245 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5T5Y3 CAMSAP1 S862 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5UIP0 RIF1 S2006 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VTR2 RNF20 S172 psp E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
Q63HK5 TSHZ3 S835 ochoa Teashirt homolog 3 (Zinc finger protein 537) Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}.
Q68EM7 ARHGAP17 S840 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6WKZ4 RAB11FIP1 S754 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZN18 AEBP2 S241 ochoa Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Q7Z6E9 RBBP6 S1462 ochoa E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}.
Q86T90 KIAA1328 S26 ochoa Protein hinderin Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}.
Q86UR5 RIMS1 S1450 ochoa Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}.
Q86UW6 N4BP2 S1216 ochoa NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}.
Q8IU85 CAMK1D S358 ochoa Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.
Q8IV32 CCDC71 S144 ochoa Coiled-coil domain-containing protein 71 None
Q8IVF2 AHNAK2 S1710 ochoa Protein AHNAK2 None
Q8IVF2 AHNAK2 S4185 ochoa Protein AHNAK2 None
Q8IVF5 TIAM2 S1545 ochoa Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.
Q8IVL0 NAV3 S1727 ochoa Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.
Q8IYD8 FANCM S1758 ochoa Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}.
Q8IYH5 ZZZ3 S426 ochoa ZZ-type zinc finger-containing protein 3 Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}.
Q8IYL3 C1orf174 S145 ochoa UPF0688 protein C1orf174 None
Q8N3C0 ASCC3 S139 ochoa Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}.
Q8N3K9 CMYA5 S362 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8ND82 ZNF280C S115 ochoa Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) May function as a transcription factor.
Q8NFT8 DNER S688 ochoa Delta and Notch-like epidermal growth factor-related receptor Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.
Q8TCU6 PREX1 S1191 ochoa Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Q8WX93 PALLD S1333 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WXG6 MADD S156 ochoa MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}.
Q8WY36 BBX S559 ochoa HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.
Q92610 ZNF592 S529 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q96EV2 RBM33 S739 ochoa RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}.
Q96II8 LRCH3 S611 ochoa DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}.
Q96KR1 ZFR S195 ochoa Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}.
Q96MT3 PRICKLE1 S379 ochoa Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.
Q96RV3 PCNX1 S159 ochoa Pecanex-like protein 1 (Pecanex homolog protein 1) None
Q96S59 RANBP9 S534 ochoa Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.
Q9BX66 SORBS1 S143 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9H6R7 WDCP S501 ochoa WD repeat and coiled-coil-containing protein None
Q9H6W3 RIOX1 S63 ochoa Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.
Q9H9J4 USP42 S494 ochoa Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.
Q9HCD5 NCOA5 S529 ochoa Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.
Q9HCD6 TANC2 S169 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9HCJ0 TNRC6C S1672 ochoa Trinucleotide repeat-containing gene 6C protein Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}.
Q9HCK8 CHD8 S440 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9NR00 TCIM S21 ochoa Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1) Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737). {ECO:0000250|UniProtKB:Q9D915, ECO:0000269|PubMed:15087392, ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:16730711, ECO:0000269|PubMed:17603013, ECO:0000269|PubMed:18959821, ECO:0000269|PubMed:19684084, ECO:0000269|PubMed:24941347, ECO:0000269|PubMed:25985737, ECO:0000305}.
Q9NVA4 TMEM184C S344 ochoa Transmembrane protein 184C (Transmembrane protein 34) Possible tumor suppressor which may play a role in cell growth. {ECO:0000269|PubMed:17072649}.
Q9P0V3 SH3BP4 S42 ochoa SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.
Q9UBL0 ARPP21 S364 ochoa cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}.
Q9UHV7 MED13 S890 ochoa Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
Q9UKX2 MYH2 S20 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 S174 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UPP1 PHF8 S793 ochoa Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}.
Q9UPQ9 TNRC6B S421 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9UQB3 CTNND2 S201 ochoa Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}.
Q9Y2F5 ICE1 S393 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y2X7 GIT1 S414 ochoa|psp ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y623 MYH4 S174 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9ULL1 PLEKHG1 S615 Sugiyama Pleckstrin homology domain-containing family G member 1 None
P05023 ATP1A1 S757 Sugiyama Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.
P13637 ATP1A3 S747 Sugiyama Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}.
P50993 ATP1A2 S754 Sugiyama Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}.
Q13733 ATP1A4 S763 Sugiyama Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
P05787 KRT8 S258 Sugiyama Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.
Q9H6F5 CCDC86 S136 Sugiyama Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}.
P33992 MCM5 S483 Sugiyama DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.
P35579 MYH9 S169 Sugiyama Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}.
Q14566 MCM6 S498 Sugiyama DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
O15013 ARHGEF10 S1330 Sugiyama Rho guanine nucleotide exchange factor 10 May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}.
Q99614 TTC1 S155 Sugiyama Tetratricopeptide repeat protein 1 (TPR repeat protein 1) None
P33992 MCM5 S424 Sugiyama DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.
P11388 TOP2A S390 Sugiyama DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}.
Q8N0Z6 TTC5 S203 SIGNOR Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap) Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair (PubMed:18451878, PubMed:31727855). In non-stress conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex. Acts as a negative regulator of nutrient stress-induced autophagy by preventing JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin (PubMed:31727855). To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (PubMed:31727855). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability. Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis. Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53. In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2 (By similarity). Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival (PubMed:18451878). Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis. Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99LG4, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:31727855}.
P35580 MYH10 S173 Sugiyama Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}.
P35749 MYH11 S173 Sugiyama Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
Q7Z406 MYH14 S193 Sugiyama Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.
Q8N6H7 ARFGAP2 S123 Sugiyama ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}.
Download
reactome_id name p -log10_p
R-HSA-8851708 Signaling by FGFR2 IIIa TM 1.204508e-07 6.919
R-HSA-1839126 FGFR2 mutant receptor activation 1.861755e-07 6.730
R-HSA-5655253 Signaling by FGFR2 in disease 1.348678e-06 5.870
R-HSA-3928663 EPHA-mediated growth cone collapse 1.565821e-05 4.805
R-HSA-1226099 Signaling by FGFR in disease 1.268125e-05 4.897
R-HSA-2682334 EPH-Ephrin signaling 5.018588e-05 4.299
R-HSA-397014 Muscle contraction 6.458171e-05 4.190
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 9.328075e-05 4.030
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 9.328075e-05 4.030
R-HSA-190241 FGFR2 ligand binding and activation 1.083524e-04 3.965
R-HSA-5654695 PI-3K cascade:FGFR2 2.113342e-04 3.675
R-HSA-9839394 TGFBR3 expression 2.113342e-04 3.675
R-HSA-176974 Unwinding of DNA 2.020662e-04 3.695
R-HSA-400685 Sema4D in semaphorin signaling 2.113342e-04 3.675
R-HSA-5654699 SHC-mediated cascade:FGFR2 2.675566e-04 3.573
R-HSA-5654700 FRS-mediated FGFR2 signaling 2.993610e-04 3.524
R-HSA-373755 Semaphorin interactions 5.462680e-04 3.263
R-HSA-390522 Striated Muscle Contraction 5.496102e-04 3.260
R-HSA-5654727 Negative regulation of FGFR2 signaling 6.023871e-04 3.220
R-HSA-5654696 Downstream signaling of activated FGFR2 6.586636e-04 3.181
R-HSA-2023837 Signaling by FGFR2 amplification mutants 1.017592e-03 2.992
R-HSA-2033519 Activated point mutants of FGFR2 1.321603e-03 2.879
R-HSA-5654738 Signaling by FGFR2 1.411381e-03 2.850
R-HSA-9839373 Signaling by TGFBR3 1.653571e-03 2.782
R-HSA-426496 Post-transcriptional silencing by small RNAs 1.970615e-03 2.705
R-HSA-109704 PI3K Cascade 2.139508e-03 2.670
R-HSA-68949 Orc1 removal from chromatin 2.415958e-03 2.617
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 3.218627e-03 2.492
R-HSA-193648 NRAGE signals death through JNK 3.040741e-03 2.517
R-HSA-5578775 Ion homeostasis 3.040741e-03 2.517
R-HSA-112399 IRS-mediated signalling 3.212617e-03 2.493
R-HSA-190236 Signaling by FGFR 3.532237e-03 2.452
R-HSA-68962 Activation of the pre-replicative complex 4.646867e-03 2.333
R-HSA-453279 Mitotic G1 phase and G1/S transition 4.306894e-03 2.366
R-HSA-936837 Ion transport by P-type ATPases 4.604493e-03 2.337
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.135116e-03 2.384
R-HSA-2428928 IRS-related events triggered by IGF1R 3.966381e-03 2.402
R-HSA-2428924 IGF1R signaling cascade 4.604493e-03 2.337
R-HSA-74751 Insulin receptor signalling cascade 4.604493e-03 2.337
R-HSA-9768778 Regulation of NPAS4 mRNA translation 4.750709e-03 2.323
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 4.750709e-03 2.323
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 4.831659e-03 2.316
R-HSA-69190 DNA strand elongation 5.392966e-03 2.268
R-HSA-73887 Death Receptor Signaling 5.402210e-03 2.267
R-HSA-176187 Activation of ATR in response to replication stress 5.791415e-03 2.237
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 7.558305e-03 2.122
R-HSA-190377 FGFR2b ligand binding and activation 7.558305e-03 2.122
R-HSA-69052 Switching of origins to a post-replicative state 6.924707e-03 2.160
R-HSA-163765 ChREBP activates metabolic gene expression 7.558305e-03 2.122
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 6.924707e-03 2.160
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 8.045218e-03 2.094
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 8.165577e-03 2.088
R-HSA-69278 Cell Cycle, Mitotic 8.286416e-03 2.082
R-HSA-416482 G alpha (12/13) signalling events 8.497081e-03 2.071
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 9.149010e-03 2.039
R-HSA-8853884 Transcriptional Regulation by VENTX 1.017179e-02 1.993
R-HSA-3214841 PKMTs methylate histone lysines 1.017179e-02 1.993
R-HSA-190375 FGFR2c ligand binding and activation 1.094658e-02 1.961
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 1.094658e-02 1.961
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 1.219926e-02 1.914
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 1.351157e-02 1.869
R-HSA-2299718 Condensation of Prophase Chromosomes 1.391986e-02 1.856
R-HSA-9708530 Regulation of BACH1 activity 1.488231e-02 1.827
R-HSA-74752 Signaling by Insulin receptor 1.503967e-02 1.823
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 1.532103e-02 1.815
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 1.602998e-02 1.795
R-HSA-9768759 Regulation of NPAS4 gene expression 1.779446e-02 1.750
R-HSA-193704 p75 NTR receptor-mediated signalling 1.924328e-02 1.716
R-HSA-9856651 MITF-M-dependent gene expression 2.007815e-02 1.697
R-HSA-5683057 MAPK family signaling cascades 2.075446e-02 1.683
R-HSA-1266738 Developmental Biology 2.156893e-02 1.666
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 2.169689e-02 1.664
R-HSA-9909620 Regulation of PD-L1(CD274) translation 2.257241e-02 1.646
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 2.257241e-02 1.646
R-HSA-8853333 Signaling by FGFR2 fusions 2.719835e-02 1.565
R-HSA-5339700 Signaling by TCF7L2 mutants 2.719835e-02 1.565
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 2.426989e-02 1.615
R-HSA-69239 Synthesis of DNA 2.476420e-02 1.606
R-HSA-162582 Signal Transduction 2.655134e-02 1.576
R-HSA-195721 Signaling by WNT 2.834193e-02 1.548
R-HSA-8943723 Regulation of PTEN mRNA translation 2.966188e-02 1.528
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 3.141151e-02 1.503
R-HSA-9909648 Regulation of PD-L1(CD274) expression 3.235937e-02 1.490
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 3.470187e-02 1.460
R-HSA-9924644 Developmental Lineages of the Mammary Gland 3.816364e-02 1.418
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 3.548147e-02 1.450
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 3.358596e-02 1.474
R-HSA-69206 G1/S Transition 4.104781e-02 1.387
R-HSA-4086398 Ca2+ pathway 3.935537e-02 1.405
R-HSA-68875 Mitotic Prophase 3.590143e-02 1.445
R-HSA-525793 Myogenesis 3.548147e-02 1.450
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 3.358596e-02 1.474
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.842492e-02 1.415
R-HSA-422475 Axon guidance 3.691627e-02 1.433
R-HSA-1640170 Cell Cycle 3.724818e-02 1.429
R-HSA-2219528 PI3K/AKT Signaling in Cancer 3.427425e-02 1.465
R-HSA-9759475 Regulation of CDH11 Expression and Function 4.170175e-02 1.380
R-HSA-199418 Negative regulation of the PI3K/AKT network 4.564033e-02 1.341
R-HSA-9659379 Sensory processing of sound 4.689754e-02 1.329
R-HSA-9734767 Developmental Cell Lineages 4.754840e-02 1.323
R-HSA-5576891 Cardiac conduction 4.755464e-02 1.323
R-HSA-4791275 Signaling by WNT in cancer 4.829693e-02 1.316
R-HSA-1538133 G0 and Early G1 4.829693e-02 1.316
R-HSA-111465 Apoptotic cleavage of cellular proteins 4.829693e-02 1.316
R-HSA-9022692 Regulation of MECP2 expression and activity 5.057434e-02 1.296
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 5.057434e-02 1.296
R-HSA-9675108 Nervous system development 5.249700e-02 1.280
R-HSA-389948 Co-inhibition by PD-1 5.257125e-02 1.279
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 5.288976e-02 1.277
R-HSA-5603029 IkBA variant leads to EDA-ID 7.090561e-02 1.149
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 5.524232e-02 1.258
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 6.232308e-02 1.205
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 6.232308e-02 1.205
R-HSA-68867 Assembly of the pre-replicative complex 7.016654e-02 1.154
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 5.763116e-02 1.239
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 6.232308e-02 1.205
R-HSA-69242 S Phase 6.792142e-02 1.168
R-HSA-2559585 Oncogene Induced Senescence 5.763116e-02 1.239
R-HSA-3858494 Beta-catenin independent WNT signaling 5.356167e-02 1.271
R-HSA-9730414 MITF-M-regulated melanocyte development 6.492172e-02 1.188
R-HSA-9679191 Potential therapeutics for SARS 7.029139e-02 1.153
R-HSA-5673001 RAF/MAP kinase cascade 6.676720e-02 1.175
R-HSA-1257604 PIP3 activates AKT signaling 7.176412e-02 1.144
R-HSA-5684996 MAPK1/MAPK3 signaling 7.261743e-02 1.139
R-HSA-69306 DNA Replication 7.392534e-02 1.131
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 7.794827e-02 1.108
R-HSA-9006936 Signaling by TGFB family members 8.276797e-02 1.082
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 8.333357e-02 1.079
R-HSA-8951430 RUNX3 regulates WNT signaling 8.783729e-02 1.056
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 8.783729e-02 1.056
R-HSA-112126 ALKBH3 mediated reversal of alkylation damage 9.618783e-02 1.017
R-HSA-4839744 Signaling by APC mutants 1.207866e-01 0.918
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.207866e-01 0.918
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.207866e-01 0.918
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.207866e-01 0.918
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.288375e-01 0.890
R-HSA-5339716 Signaling by GSK3beta mutants 1.288375e-01 0.890
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 1.238096e-01 0.907
R-HSA-164843 2-LTR circle formation 1.126618e-01 0.948
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 9.161656e-02 1.038
R-HSA-9032845 Activated NTRK2 signals through CDK5 8.783729e-02 1.056
R-HSA-4839735 Signaling by AXIN mutants 1.288375e-01 0.890
R-HSA-4839748 Signaling by AMER1 mutants 1.288375e-01 0.890
R-HSA-69002 DNA Replication Pre-Initiation 1.013472e-01 0.994
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 9.948878e-02 1.002
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.044624e-01 0.981
R-HSA-201681 TCF dependent signaling in response to WNT 1.167551e-01 0.933
R-HSA-68884 Mitotic Telophase/Cytokinesis 1.288375e-01 0.890
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 1.059213e-01 0.975
R-HSA-445355 Smooth Muscle Contraction 1.088512e-01 0.963
R-HSA-9006925 Intracellular signaling by second messengers 1.180719e-01 0.928
R-HSA-448706 Interleukin-1 processing 1.044624e-01 0.981
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 1.238096e-01 0.907
R-HSA-388841 Regulation of T cell activation by CD28 family 1.120400e-01 0.951
R-HSA-162592 Integration of provirus 1.288375e-01 0.890
R-HSA-5689880 Ub-specific processing proteases 1.019282e-01 0.992
R-HSA-9662834 CD163 mediating an anti-inflammatory response 1.207866e-01 0.918
R-HSA-3247509 Chromatin modifying enzymes 8.624008e-02 1.064
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 9.618783e-02 1.017
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 9.764438e-02 1.010
R-HSA-4839726 Chromatin organization 1.034593e-01 0.985
R-HSA-9700206 Signaling by ALK in cancer 9.764438e-02 1.010
R-HSA-421270 Cell-cell junction organization 1.058763e-01 0.975
R-HSA-5688426 Deubiquitination 1.107935e-01 0.955
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 1.019282e-01 0.992
R-HSA-9764265 Regulation of CDH1 Expression and Function 1.019282e-01 0.992
R-HSA-211000 Gene Silencing by RNA 9.764438e-02 1.010
R-HSA-9634815 Transcriptional Regulation by NPAS4 1.059213e-01 0.975
R-HSA-983712 Ion channel transport 1.260801e-01 0.899
R-HSA-75153 Apoptotic execution phase 8.882918e-02 1.051
R-HSA-5357905 Regulation of TNFR1 signaling 8.882918e-02 1.051
R-HSA-75893 TNF signaling 1.177668e-01 0.929
R-HSA-168325 Viral Messenger RNA Synthesis 1.330101e-01 0.876
R-HSA-8939902 Regulation of RUNX2 expression and activity 1.330101e-01 0.876
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.368152e-01 0.864
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.368152e-01 0.864
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.368152e-01 0.864
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.368152e-01 0.864
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.368152e-01 0.864
R-HSA-196299 Beta-catenin phosphorylation cascade 1.603154e-01 0.795
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 1.680067e-01 0.775
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1.980785e-01 0.703
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 2.199216e-01 0.658
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 2.199216e-01 0.658
R-HSA-6803529 FGFR2 alternative splicing 2.270704e-01 0.644
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 2.341542e-01 0.630
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 2.341542e-01 0.630
R-HSA-445095 Interaction between L1 and Ankyrins 2.618504e-01 0.582
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.618504e-01 0.582
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.618504e-01 0.582
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 2.686175e-01 0.571
R-HSA-113418 Formation of the Early Elongation Complex 2.686175e-01 0.571
R-HSA-167287 HIV elongation arrest and recovery 2.686175e-01 0.571
R-HSA-167290 Pausing and recovery of HIV elongation 2.686175e-01 0.571
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.550210e-01 0.593
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.614533e-01 0.792
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 2.175631e-01 0.662
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 1.756281e-01 0.755
R-HSA-4641265 Repression of WNT target genes 1.368152e-01 0.864
R-HSA-3928664 Ephrin signaling 1.906633e-01 0.720
R-HSA-399956 CRMPs in Sema3A signaling 1.525535e-01 0.817
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 2.111144e-01 0.675
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 1.603154e-01 0.795
R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.906633e-01 0.720
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 1.906633e-01 0.720
R-HSA-933542 TRAF6 mediated NF-kB activation 2.411735e-01 0.618
R-HSA-6807878 COPI-mediated anterograde transport 2.581199e-01 0.588
R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 1.368152e-01 0.864
R-HSA-9620244 Long-term potentiation 2.481290e-01 0.605
R-HSA-162587 HIV Life Cycle 2.182548e-01 0.661
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 2.270704e-01 0.644
R-HSA-73942 DNA Damage Reversal 1.603154e-01 0.795
R-HSA-6809371 Formation of the cornified envelope 1.349429e-01 0.870
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 2.581199e-01 0.588
R-HSA-212165 Epigenetic regulation of gene expression 2.093505e-01 0.679
R-HSA-1912408 Pre-NOTCH Transcription and Translation 2.344136e-01 0.630
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 2.127070e-01 0.672
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 2.411735e-01 0.618
R-HSA-420029 Tight junction interactions 2.481290e-01 0.605
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.618504e-01 0.582
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 2.199216e-01 0.658
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 2.550210e-01 0.593
R-HSA-8878171 Transcriptional regulation by RUNX1 1.916094e-01 0.718
R-HSA-8851805 MET activates RAS signaling 1.368152e-01 0.864
R-HSA-3270619 IRF3-mediated induction of type I IFN 1.603154e-01 0.795
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 2.063839e-01 0.685
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 1.906633e-01 0.720
R-HSA-438064 Post NMDA receptor activation events 2.209252e-01 0.656
R-HSA-3214842 HDMs demethylate histones 2.481290e-01 0.605
R-HSA-9823730 Formation of definitive endoderm 2.054262e-01 0.687
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 2.199216e-01 0.658
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 2.411735e-01 0.618
R-HSA-8863678 Neurodegenerative Diseases 2.411735e-01 0.618
R-HSA-9018519 Estrogen-dependent gene expression 1.673111e-01 0.776
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.711677e-01 0.767
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.618504e-01 0.582
R-HSA-8852135 Protein ubiquitination 1.776974e-01 0.750
R-HSA-5693532 DNA Double-Strand Break Repair 2.087461e-01 0.680
R-HSA-9629569 Protein hydroxylation 2.054262e-01 0.687
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 2.550210e-01 0.593
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.411735e-01 0.618
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 1.373438e-01 0.862
R-HSA-69481 G2/M Checkpoints 1.433490e-01 0.844
R-HSA-68886 M Phase 1.681002e-01 0.774
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 1.614533e-01 0.792
R-HSA-9006115 Signaling by NTRK2 (TRKB) 2.618504e-01 0.582
R-HSA-418990 Adherens junctions interactions 1.769865e-01 0.752
R-HSA-8986944 Transcriptional Regulation by MECP2 2.344136e-01 0.630
R-HSA-446728 Cell junction organization 1.411336e-01 0.850
R-HSA-1989781 PPARA activates gene expression 2.134887e-01 0.671
R-HSA-3000170 Syndecan interactions 2.341542e-01 0.630
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 2.182548e-01 0.661
R-HSA-1500931 Cell-Cell communication 1.980784e-01 0.703
R-HSA-70221 Glycogen breakdown (glycogenolysis) 2.481290e-01 0.605
R-HSA-844456 The NLRP3 inflammasome 1.980785e-01 0.703
R-HSA-1834941 STING mediated induction of host immune responses 1.980785e-01 0.703
R-HSA-162594 Early Phase of HIV Life Cycle 2.127070e-01 0.672
R-HSA-5687128 MAPK6/MAPK4 signaling 2.108535e-01 0.676
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 1.392281e-01 0.856
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 1.785708e-01 0.748
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.908685e-01 0.719
R-HSA-9664417 Leishmania phagocytosis 1.763020e-01 0.754
R-HSA-9664407 Parasite infection 1.763020e-01 0.754
R-HSA-9664422 FCGR3A-mediated phagocytosis 1.763020e-01 0.754
R-HSA-622312 Inflammasomes 2.686175e-01 0.571
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 2.620132e-01 0.582
R-HSA-73894 DNA Repair 2.719831e-01 0.565
R-HSA-72086 mRNA Capping 2.753230e-01 0.560
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.753230e-01 0.560
R-HSA-9006931 Signaling by Nuclear Receptors 2.772430e-01 0.557
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 2.784732e-01 0.555
R-HSA-2559580 Oxidative Stress Induced Senescence 2.784732e-01 0.555
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.819675e-01 0.550
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 2.819675e-01 0.550
R-HSA-888590 GABA synthesis, release, reuptake and degradation 2.819675e-01 0.550
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.885514e-01 0.540
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.885514e-01 0.540
R-HSA-2129379 Molecules associated with elastic fibres 2.885514e-01 0.540
R-HSA-9833110 RSV-host interactions 2.886407e-01 0.540
R-HSA-9675126 Diseases of mitotic cell cycle 2.950754e-01 0.530
R-HSA-9658195 Leishmania infection 3.001073e-01 0.523
R-HSA-9824443 Parasitic Infection Pathways 3.001073e-01 0.523
R-HSA-1855170 IPs transport between nucleus and cytosol 3.015399e-01 0.521
R-HSA-159227 Transport of the SLBP independent Mature mRNA 3.015399e-01 0.521
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 3.015399e-01 0.521
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.079456e-01 0.512
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.079456e-01 0.512
R-HSA-8964539 Glutamate and glutamine metabolism 3.079456e-01 0.512
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 3.079456e-01 0.512
R-HSA-180746 Nuclear import of Rev protein 3.142929e-01 0.503
R-HSA-1912422 Pre-NOTCH Expression and Processing 3.190237e-01 0.496
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.205824e-01 0.494
R-HSA-212300 PRC2 methylates histones and DNA 3.268146e-01 0.486
R-HSA-5628897 TP53 Regulates Metabolic Genes 3.290906e-01 0.483
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.329900e-01 0.478
R-HSA-5689896 Ovarian tumor domain proteases 3.329900e-01 0.478
R-HSA-373760 L1CAM interactions 3.357800e-01 0.474
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.391091e-01 0.470
R-HSA-1566948 Elastic fibre formation 3.391091e-01 0.470
R-HSA-6805567 Keratinization 3.443333e-01 0.463
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 3.451725e-01 0.462
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 3.451725e-01 0.462
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.451725e-01 0.462
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 3.451725e-01 0.462
R-HSA-8878166 Transcriptional regulation by RUNX2 3.457773e-01 0.461
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 3.511806e-01 0.454
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 3.511806e-01 0.454
R-HSA-167169 HIV Transcription Elongation 3.511806e-01 0.454
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 3.511806e-01 0.454
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 3.511806e-01 0.454
R-HSA-177243 Interactions of Rev with host cellular proteins 3.511806e-01 0.454
R-HSA-176033 Interactions of Vpr with host cellular proteins 3.511806e-01 0.454
R-HSA-5260271 Diseases of Immune System 3.511806e-01 0.454
R-HSA-5602358 Diseases associated with the TLR signaling cascade 3.511806e-01 0.454
R-HSA-8982491 Glycogen metabolism 3.511806e-01 0.454
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 3.571339e-01 0.447
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 3.571339e-01 0.447
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 3.571339e-01 0.447
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 3.630330e-01 0.440
R-HSA-167161 HIV Transcription Initiation 3.630330e-01 0.440
R-HSA-75953 RNA Polymerase II Transcription Initiation 3.630330e-01 0.440
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 3.630330e-01 0.440
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 3.653465e-01 0.437
R-HSA-400508 Incretin synthesis, secretion, and inactivation 3.688783e-01 0.433
R-HSA-73776 RNA Polymerase II Promoter Escape 3.746704e-01 0.426
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 3.804096e-01 0.420
R-HSA-69236 G1 Phase 3.804096e-01 0.420
R-HSA-69231 Cyclin D associated events in G1 3.804096e-01 0.420
R-HSA-3928662 EPHB-mediated forward signaling 3.804096e-01 0.420
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 3.860965e-01 0.413
R-HSA-6783310 Fanconi Anemia Pathway 3.860965e-01 0.413
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 3.860965e-01 0.413
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.860965e-01 0.413
R-HSA-4608870 Asymmetric localization of PCP proteins 3.860965e-01 0.413
R-HSA-72165 mRNA Splicing - Minor Pathway 3.917316e-01 0.407
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 3.917316e-01 0.407
R-HSA-9861718 Regulation of pyruvate metabolism 3.917316e-01 0.407
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 3.917316e-01 0.407
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 3.917316e-01 0.407
R-HSA-8856688 Golgi-to-ER retrograde transport 3.949453e-01 0.403
R-HSA-162906 HIV Infection 3.965798e-01 0.402
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 3.973153e-01 0.401
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 4.028481e-01 0.395
R-HSA-163685 Integration of energy metabolism 4.109726e-01 0.386
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 4.141535e-01 0.383
R-HSA-199991 Membrane Trafficking 4.180499e-01 0.379
R-HSA-1169091 Activation of NF-kappaB in B cells 4.191455e-01 0.378
R-HSA-6807070 PTEN Regulation 4.204899e-01 0.376
R-HSA-8939211 ESR-mediated signaling 4.211076e-01 0.376
R-HSA-112382 Formation of RNA Pol II elongation complex 4.244792e-01 0.372
R-HSA-6794361 Neurexins and neuroligins 4.244792e-01 0.372
R-HSA-157118 Signaling by NOTCH 4.284042e-01 0.368
R-HSA-75955 RNA Polymerase II Transcription Elongation 4.297643e-01 0.367
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 4.297643e-01 0.367
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 4.297643e-01 0.367
R-HSA-9639288 Amino acids regulate mTORC1 4.297643e-01 0.367
R-HSA-162599 Late Phase of HIV Life Cycle 4.330578e-01 0.363
R-HSA-199977 ER to Golgi Anterograde Transport 4.485626e-01 0.348
R-HSA-2980766 Nuclear Envelope Breakdown 4.504267e-01 0.346
R-HSA-194441 Metabolism of non-coding RNA 4.604773e-01 0.337
R-HSA-191859 snRNP Assembly 4.604773e-01 0.337
R-HSA-9755511 KEAP1-NFE2L2 pathway 4.607954e-01 0.336
R-HSA-983189 Kinesins 4.654340e-01 0.332
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.698667e-01 0.328
R-HSA-69620 Cell Cycle Checkpoints 4.714537e-01 0.327
R-HSA-168273 Influenza Viral RNA Transcription and Replication 4.728703e-01 0.325
R-HSA-6784531 tRNA processing in the nucleus 4.752119e-01 0.323
R-HSA-9616222 Transcriptional regulation of granulopoiesis 4.752119e-01 0.323
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 4.800341e-01 0.319
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.800341e-01 0.319
R-HSA-6790901 rRNA modification in the nucleus and cytosol 4.800341e-01 0.319
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 4.848122e-01 0.314
R-HSA-109581 Apoptosis 4.936084e-01 0.307
R-HSA-8854518 AURKA Activation by TPX2 4.942381e-01 0.306
R-HSA-167172 Transcription of the HIV genome 5.034926e-01 0.298
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 5.125789e-01 0.290
R-HSA-69202 Cyclin E associated events during G1/S transition 5.125789e-01 0.290
R-HSA-75105 Fatty acyl-CoA biosynthesis 5.125789e-01 0.290
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.170600e-01 0.286
R-HSA-3000178 ECM proteoglycans 5.170600e-01 0.286
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 5.170600e-01 0.286
R-HSA-453276 Regulation of mitotic cell cycle 5.170600e-01 0.286
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 5.215001e-01 0.283
R-HSA-5578749 Transcriptional regulation by small RNAs 5.215001e-01 0.283
R-HSA-5621481 C-type lectin receptors (CLRs) 5.223320e-01 0.282
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 5.258996e-01 0.279
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5.258996e-01 0.279
R-HSA-674695 RNA Polymerase II Pre-transcription Events 5.302590e-01 0.276
R-HSA-380287 Centrosome maturation 5.345786e-01 0.272
R-HSA-1169408 ISG15 antiviral mechanism 5.345786e-01 0.272
R-HSA-3000171 Non-integrin membrane-ECM interactions 5.345786e-01 0.272
R-HSA-1980143 Signaling by NOTCH1 5.388587e-01 0.269
R-HSA-168255 Influenza Infection 5.445198e-01 0.264
R-HSA-2559583 Cellular Senescence 5.472428e-01 0.262
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 5.473019e-01 0.262
R-HSA-4086400 PCP/CE pathway 5.473019e-01 0.262
R-HSA-216083 Integrin cell surface interactions 5.473019e-01 0.262
R-HSA-9833482 PKR-mediated signaling 5.555917e-01 0.255
R-HSA-6806834 Signaling by MET 5.555917e-01 0.255
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 5.637306e-01 0.249
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 5.677443e-01 0.246
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 5.717214e-01 0.243
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 5.717214e-01 0.243
R-HSA-6794362 Protein-protein interactions at synapses 5.756622e-01 0.240
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 5.795669e-01 0.237
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 5.834359e-01 0.234
R-HSA-70268 Pyruvate metabolism 5.872696e-01 0.231
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.910682e-01 0.228
R-HSA-9645723 Diseases of programmed cell death 5.910682e-01 0.228
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 5.985616e-01 0.223
R-HSA-112310 Neurotransmitter release cycle 5.985616e-01 0.223
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 5.993105e-01 0.222
R-HSA-948021 Transport to the Golgi and subsequent modification 6.042648e-01 0.219
R-HSA-112315 Transmission across Chemical Synapses 6.127220e-01 0.213
R-HSA-9679506 SARS-CoV Infections 6.133640e-01 0.212
R-HSA-5357801 Programmed Cell Death 6.140351e-01 0.212
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 6.202331e-01 0.207
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 6.202331e-01 0.207
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 6.271955e-01 0.203
R-HSA-5607764 CLEC7A (Dectin-1) signaling 6.271955e-01 0.203
R-HSA-8878159 Transcriptional regulation by RUNX3 6.306290e-01 0.200
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 6.306911e-01 0.200
R-HSA-975871 MyD88 cascade initiated on plasma membrane 6.340311e-01 0.198
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 6.340311e-01 0.198
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 6.340311e-01 0.198
R-HSA-3214847 HATs acetylate histones 6.374020e-01 0.196
R-HSA-1643685 Disease 6.376312e-01 0.195
R-HSA-70171 Glycolysis 6.407422e-01 0.193
R-HSA-5653656 Vesicle-mediated transport 6.436734e-01 0.191
R-HSA-9020702 Interleukin-1 signaling 6.440517e-01 0.191
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 6.473310e-01 0.189
R-HSA-1280218 Adaptive Immune System 6.522656e-01 0.186
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 6.537998e-01 0.185
R-HSA-3700989 Transcriptional Regulation by TP53 6.558992e-01 0.183
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 6.601507e-01 0.180
R-HSA-74160 Gene expression (Transcription) 6.632169e-01 0.178
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6.694608e-01 0.174
R-HSA-975155 MyD88 dependent cascade initiated on endosome 6.725075e-01 0.172
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 6.755263e-01 0.170
R-HSA-166166 MyD88-independent TLR4 cascade 6.755263e-01 0.170
R-HSA-1483249 Inositol phosphate metabolism 6.814813e-01 0.167
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 6.844179e-01 0.165
R-HSA-597592 Post-translational protein modification 6.897826e-01 0.161
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 6.930675e-01 0.159
R-HSA-9007101 Rab regulation of trafficking 7.014815e-01 0.154
R-HSA-70326 Glucose metabolism 7.014815e-01 0.154
R-HSA-2980736 Peptide hormone metabolism 7.014815e-01 0.154
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 7.069632e-01 0.151
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 7.069632e-01 0.151
R-HSA-3371556 Cellular response to heat stress 7.123448e-01 0.147
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 7.149987e-01 0.146
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 7.149987e-01 0.146
R-HSA-9816359 Maternal to zygotic transition (MZT) 7.176283e-01 0.144
R-HSA-2132295 MHC class II antigen presentation 7.176283e-01 0.144
R-HSA-162909 Host Interactions of HIV factors 7.202338e-01 0.143
R-HSA-977606 Regulation of Complement cascade 7.228154e-01 0.141
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.253734e-01 0.139
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.253734e-01 0.139
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.253734e-01 0.139
R-HSA-114608 Platelet degranulation 7.304191e-01 0.136
R-HSA-9824446 Viral Infection Pathways 7.351291e-01 0.134
R-HSA-9843745 Adipogenesis 7.426343e-01 0.129
R-HSA-9711123 Cellular response to chemical stress 7.443362e-01 0.128
R-HSA-9909396 Circadian clock 7.450105e-01 0.128
R-HSA-1474228 Degradation of the extracellular matrix 7.450105e-01 0.128
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.473649e-01 0.126
R-HSA-9948299 Ribosome-associated quality control 7.610449e-01 0.119
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 7.628063e-01 0.118
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 7.676403e-01 0.115
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 7.718810e-01 0.112
R-HSA-8856828 Clathrin-mediated endocytosis 7.739889e-01 0.111
R-HSA-166658 Complement cascade 7.781469e-01 0.109
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 7.842418e-01 0.106
R-HSA-166520 Signaling by NTRKs 7.842418e-01 0.106
R-HSA-9758941 Gastrulation 7.862362e-01 0.104
R-HSA-212436 Generic Transcription Pathway 7.901163e-01 0.102
R-HSA-446652 Interleukin-1 family signaling 7.921103e-01 0.101
R-HSA-9610379 HCMV Late Events 8.015463e-01 0.096
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 8.033818e-01 0.095
R-HSA-9711097 Cellular response to starvation 8.033818e-01 0.095
R-HSA-5663205 Infectious disease 8.035049e-01 0.095
R-HSA-73857 RNA Polymerase II Transcription 8.054780e-01 0.094
R-HSA-5633007 Regulation of TP53 Activity 8.070024e-01 0.093
R-HSA-5619102 SLC transporter disorders 8.191607e-01 0.087
R-HSA-72306 tRNA processing 8.257636e-01 0.083
R-HSA-8957322 Metabolism of steroids 8.268414e-01 0.083
R-HSA-112316 Neuronal System 8.300981e-01 0.081
R-HSA-9664433 Leishmania parasite growth and survival 8.305580e-01 0.081
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 8.305580e-01 0.081
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 8.336813e-01 0.079
R-HSA-1474244 Extracellular matrix organization 8.352856e-01 0.078
R-HSA-69275 G2/M Transition 8.498644e-01 0.071
R-HSA-453274 Mitotic G2-G2/M phases 8.526341e-01 0.069
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.526341e-01 0.069
R-HSA-5617833 Cilium Assembly 8.553530e-01 0.068
R-HSA-168898 Toll-like Receptor Cascades 8.566937e-01 0.067
R-HSA-68877 Mitotic Prometaphase 8.593381e-01 0.066
R-HSA-72163 mRNA Splicing - Major Pathway 8.606422e-01 0.065
R-HSA-9609690 HCMV Early Events 8.632142e-01 0.064
R-HSA-72172 mRNA Splicing 8.742174e-01 0.058
R-HSA-168249 Innate Immune System 8.807033e-01 0.055
R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.880891e-01 0.052
R-HSA-913531 Interferon Signaling 8.880891e-01 0.052
R-HSA-8951664 Neddylation 8.926578e-01 0.049
R-HSA-9705683 SARS-CoV-2-host interactions 8.994461e-01 0.046
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 9.013060e-01 0.045
R-HSA-72312 rRNA processing 9.031318e-01 0.044
R-HSA-5619115 Disorders of transmembrane transporters 9.157970e-01 0.038
R-HSA-446203 Asparagine N-linked glycosylation 9.164652e-01 0.038
R-HSA-9609646 HCMV Infection 9.181252e-01 0.037
R-HSA-2262752 Cellular responses to stress 9.208069e-01 0.036
R-HSA-76002 Platelet activation, signaling and aggregation 9.345898e-01 0.029
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.350788e-01 0.029
R-HSA-6798695 Neutrophil degranulation 9.360712e-01 0.029
R-HSA-388396 GPCR downstream signalling 9.375355e-01 0.028
R-HSA-168256 Immune System 9.448449e-01 0.025
R-HSA-392499 Metabolism of proteins 9.470366e-01 0.024
R-HSA-1852241 Organelle biogenesis and maintenance 9.575040e-01 0.019
R-HSA-8953897 Cellular responses to stimuli 9.609847e-01 0.017
R-HSA-372790 Signaling by GPCR 9.633307e-01 0.016
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.651132e-01 0.015
R-HSA-9694516 SARS-CoV-2 Infection 9.676415e-01 0.014
R-HSA-196854 Metabolism of vitamins and cofactors 9.719016e-01 0.012
R-HSA-8978868 Fatty acid metabolism 9.814428e-01 0.008
R-HSA-382551 Transport of small molecules 9.841594e-01 0.007
R-HSA-72766 Translation 9.849257e-01 0.007
R-HSA-8953854 Metabolism of RNA 9.865559e-01 0.006
R-HSA-109582 Hemostasis 9.955577e-01 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 9.975030e-01 0.001
R-HSA-449147 Signaling by Interleukins 9.976648e-01 0.001
R-HSA-1280215 Cytokine Signaling in Immune system 9.979259e-01 0.001
R-HSA-556833 Metabolism of lipids 9.986206e-01 0.001
R-HSA-9709957 Sensory Perception 9.994582e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.843 0.074 2 0.818
CLK3CLK3 0.841 0.239 1 0.813
NLKNLK 0.841 0.211 1 0.852
CDC7CDC7 0.833 -0.033 1 0.767
TBK1TBK1 0.832 0.012 1 0.718
CAMK1BCAMK1B 0.832 0.048 -3 0.784
PIM3PIM3 0.832 0.038 -3 0.775
MTORMTOR 0.831 0.001 1 0.765
HIPK4HIPK4 0.831 0.130 1 0.809
PRKD1PRKD1 0.830 0.043 -3 0.754
NDR2NDR2 0.830 0.014 -3 0.786
ERK5ERK5 0.830 0.088 1 0.794
ATRATR 0.829 0.072 1 0.822
NUAK2NUAK2 0.829 0.052 -3 0.770
AMPKA1AMPKA1 0.829 0.095 -3 0.788
ULK2ULK2 0.829 -0.040 2 0.745
GCN2GCN2 0.829 -0.102 2 0.741
TSSK1TSSK1 0.829 0.127 -3 0.813
NDR1NDR1 0.829 0.044 -3 0.772
PRKD2PRKD2 0.828 0.071 -3 0.714
PRPKPRPK 0.828 -0.157 -1 0.825
CDKL1CDKL1 0.828 0.043 -3 0.714
RAF1RAF1 0.828 -0.054 1 0.784
CDKL5CDKL5 0.828 0.065 -3 0.708
RSK2RSK2 0.828 0.068 -3 0.705
PKN3PKN3 0.828 0.039 -3 0.751
KISKIS 0.828 0.158 1 0.783
TSSK2TSSK2 0.827 0.103 -5 0.791
ICKICK 0.827 0.132 -3 0.751
DYRK2DYRK2 0.827 0.213 1 0.776
MOSMOS 0.826 -0.031 1 0.788
SRPK1SRPK1 0.826 0.097 -3 0.671
IKKEIKKE 0.826 -0.031 1 0.713
P90RSKP90RSK 0.826 0.037 -3 0.703
PKCDPKCD 0.826 0.103 2 0.723
RIPK3RIPK3 0.826 0.019 3 0.733
TGFBR2TGFBR2 0.826 0.008 -2 0.784
IKKBIKKB 0.826 -0.078 -2 0.751
WNK1WNK1 0.825 0.035 -2 0.855
CAMLCKCAMLCK 0.825 0.085 -2 0.882
DAPK2DAPK2 0.825 0.097 -3 0.781
PDHK4PDHK4 0.825 -0.211 1 0.800
CDK8CDK8 0.825 0.174 1 0.764
MAPKAPK3MAPKAPK3 0.825 0.008 -3 0.714
MARK4MARK4 0.824 0.026 4 0.844
NIKNIK 0.824 0.033 -3 0.805
CLK1CLK1 0.824 0.182 -3 0.680
AMPKA2AMPKA2 0.824 0.082 -3 0.761
PDHK1PDHK1 0.824 -0.121 1 0.803
BMPR2BMPR2 0.823 -0.125 -2 0.864
RSK3RSK3 0.823 0.031 -3 0.700
PKN2PKN2 0.823 0.038 -3 0.758
CLK4CLK4 0.823 0.171 -3 0.698
NEK6NEK6 0.823 0.001 -2 0.851
SRPK2SRPK2 0.822 0.091 -3 0.601
JNK2JNK2 0.822 0.235 1 0.726
LATS2LATS2 0.822 0.005 -5 0.679
CDK7CDK7 0.822 0.161 1 0.760
NUAK1NUAK1 0.822 0.059 -3 0.734
PKACGPKACG 0.822 0.088 -2 0.796
SKMLCKSKMLCK 0.822 0.055 -2 0.856
CAMK4CAMK4 0.822 0.049 -3 0.755
MST4MST4 0.821 0.011 2 0.763
MELKMELK 0.821 0.074 -3 0.743
WNK3WNK3 0.821 -0.031 1 0.761
MNK2MNK2 0.821 0.098 -2 0.836
PIM1PIM1 0.821 0.049 -3 0.720
CDK19CDK19 0.820 0.172 1 0.733
P70S6KBP70S6KB 0.820 0.047 -3 0.726
NEK7NEK7 0.820 -0.063 -3 0.720
NIM1NIM1 0.820 0.012 3 0.764
DSTYKDSTYK 0.819 -0.083 2 0.795
CHK1CHK1 0.819 0.077 -3 0.797
AURCAURC 0.819 0.118 -2 0.716
ULK1ULK1 0.819 -0.074 -3 0.716
CAMK2GCAMK2G 0.818 -0.112 2 0.740
CAMK2DCAMK2D 0.817 -0.049 -3 0.756
PRKD3PRKD3 0.817 0.050 -3 0.673
CDK5CDK5 0.817 0.191 1 0.764
CDK18CDK18 0.817 0.192 1 0.692
JNK3JNK3 0.817 0.216 1 0.746
AURBAURB 0.817 0.136 -2 0.720
MLK1MLK1 0.817 -0.073 2 0.748
P38AP38A 0.817 0.191 1 0.770
MAPKAPK2MAPKAPK2 0.817 -0.007 -3 0.681
PAK3PAK3 0.816 0.061 -2 0.829
PAK6PAK6 0.816 0.107 -2 0.787
ANKRD3ANKRD3 0.815 0.005 1 0.817
IRE2IRE2 0.815 0.047 2 0.732
QIKQIK 0.815 0.012 -3 0.746
QSKQSK 0.815 0.040 4 0.826
IKKAIKKA 0.815 -0.005 -2 0.723
HIPK1HIPK1 0.814 0.201 1 0.780
P38BP38B 0.814 0.205 1 0.722
HIPK2HIPK2 0.814 0.201 1 0.708
CHAK2CHAK2 0.814 -0.047 -1 0.799
HIPK3HIPK3 0.814 0.189 1 0.793
MASTLMASTL 0.814 -0.168 -2 0.825
PAK1PAK1 0.813 0.066 -2 0.819
MNK1MNK1 0.813 0.090 -2 0.844
PKG2PKG2 0.813 0.108 -2 0.737
DYRK1ADYRK1A 0.813 0.165 1 0.799
CDK17CDK17 0.813 0.193 1 0.650
HUNKHUNK 0.813 -0.133 2 0.773
SIKSIK 0.813 0.030 -3 0.697
CDK1CDK1 0.812 0.186 1 0.714
GRK5GRK5 0.812 -0.164 -3 0.778
MLK2MLK2 0.812 -0.058 2 0.748
SRPK3SRPK3 0.812 0.054 -3 0.637
NEK9NEK9 0.812 -0.105 2 0.768
PHKG1PHKG1 0.812 -0.012 -3 0.759
IRE1IRE1 0.812 -0.044 1 0.713
ERK1ERK1 0.812 0.184 1 0.720
CDK13CDK13 0.812 0.143 1 0.736
DYRK3DYRK3 0.811 0.202 1 0.784
PLK1PLK1 0.811 0.030 -2 0.835
P38GP38G 0.811 0.200 1 0.652
ERK2ERK2 0.811 0.182 1 0.741
SGK3SGK3 0.811 0.097 -3 0.689
LATS1LATS1 0.811 0.050 -3 0.799
RIPK1RIPK1 0.810 -0.111 1 0.757
MSK2MSK2 0.810 0.014 -3 0.657
BRSK2BRSK2 0.810 -0.017 -3 0.747
DLKDLK 0.810 -0.101 1 0.785
CDK14CDK14 0.810 0.199 1 0.727
BCKDKBCKDK 0.810 -0.177 -1 0.774
ATMATM 0.809 0.018 1 0.784
PAK2PAK2 0.809 0.066 -2 0.815
CDK2CDK2 0.809 0.134 1 0.763
DYRK4DYRK4 0.809 0.198 1 0.723
CLK2CLK2 0.809 0.168 -3 0.700
MYLK4MYLK4 0.809 0.059 -2 0.811
RSK4RSK4 0.809 0.054 -3 0.686
PKACBPKACB 0.809 0.104 -2 0.737
GRK6GRK6 0.809 -0.083 1 0.768
AKT2AKT2 0.808 0.075 -3 0.621
ALK4ALK4 0.808 0.000 -2 0.797
MARK2MARK2 0.808 0.028 4 0.749
MSK1MSK1 0.808 0.062 -3 0.672
DYRK1BDYRK1B 0.808 0.192 1 0.729
PKCAPKCA 0.807 0.021 2 0.663
CAMK2BCAMK2B 0.807 -0.029 2 0.688
PKCGPKCG 0.807 0.002 2 0.681
MARK3MARK3 0.807 0.021 4 0.784
CDK3CDK3 0.806 0.192 1 0.667
PIM2PIM2 0.806 0.044 -3 0.678
P38DP38D 0.806 0.208 1 0.685
PKRPKR 0.806 -0.022 1 0.766
VRK2VRK2 0.806 -0.009 1 0.835
PLK4PLK4 0.806 0.002 2 0.644
CDK9CDK9 0.806 0.126 1 0.740
PKCBPKCB 0.805 -0.003 2 0.676
MEK1MEK1 0.805 -0.082 2 0.784
CDK12CDK12 0.805 0.144 1 0.719
AKT1AKT1 0.805 0.115 -3 0.641
BRSK1BRSK1 0.805 -0.028 -3 0.727
AURAAURA 0.805 0.093 -2 0.686
DNAPKDNAPK 0.804 0.041 1 0.736
NEK2NEK2 0.804 -0.069 2 0.753
PKCHPKCH 0.804 -0.004 2 0.673
PKCZPKCZ 0.804 -0.014 2 0.721
CDK16CDK16 0.804 0.193 1 0.665
CAMK2ACAMK2A 0.804 -0.037 2 0.716
MLK3MLK3 0.804 -0.056 2 0.672
MARK1MARK1 0.804 0.010 4 0.807
BMPR1BBMPR1B 0.803 0.029 1 0.705
SMG1SMG1 0.803 -0.006 1 0.781
SNRKSNRK 0.803 -0.072 2 0.695
PHKG2PHKG2 0.803 0.018 -3 0.734
SSTKSSTK 0.803 0.059 4 0.828
DCAMKL1DCAMKL1 0.803 0.020 -3 0.735
YSK4YSK4 0.802 -0.088 1 0.725
TGFBR1TGFBR1 0.802 -0.019 -2 0.758
CDK10CDK10 0.802 0.177 1 0.718
SMMLCKSMMLCK 0.801 0.070 -3 0.730
PRP4PRP4 0.801 0.073 -3 0.662
FAM20CFAM20C 0.801 -0.040 2 0.505
TTBK2TTBK2 0.801 -0.184 2 0.660
GRK4GRK4 0.801 -0.154 -2 0.769
PRKXPRKX 0.801 0.103 -3 0.636
CAMK1GCAMK1G 0.801 -0.010 -3 0.682
GRK1GRK1 0.801 -0.060 -2 0.732
CAMK1DCAMK1D 0.800 0.052 -3 0.635
WNK4WNK4 0.800 -0.009 -2 0.857
PLK3PLK3 0.799 -0.036 2 0.729
ACVR2AACVR2A 0.799 -0.015 -2 0.768
IRAK4IRAK4 0.799 -0.020 1 0.733
CHAK1CHAK1 0.799 -0.107 2 0.722
MLK4MLK4 0.799 -0.051 2 0.657
TLK2TLK2 0.799 -0.020 1 0.766
PKCTPKCT 0.798 0.027 2 0.676
ACVR2BACVR2B 0.797 -0.017 -2 0.778
DCAMKL2DCAMKL2 0.797 -0.012 -3 0.755
PKACAPKACA 0.797 0.087 -2 0.688
PERKPERK 0.796 -0.086 -2 0.829
PAK5PAK5 0.796 0.075 -2 0.713
PINK1PINK1 0.796 -0.044 1 0.786
HRIHRI 0.796 -0.116 -2 0.844
P70S6KP70S6K 0.796 -0.003 -3 0.628
BRAFBRAF 0.796 -0.024 -4 0.786
CDK4CDK4 0.796 0.184 1 0.704
PKN1PKN1 0.795 0.037 -3 0.644
DRAK1DRAK1 0.795 -0.076 1 0.696
MEKK1MEKK1 0.794 -0.061 1 0.797
ZAKZAK 0.794 -0.052 1 0.762
MAPKAPK5MAPKAPK5 0.794 -0.118 -3 0.623
MEK5MEK5 0.794 -0.138 2 0.772
CDK6CDK6 0.793 0.169 1 0.716
CAMK1ACAMK1A 0.793 0.061 -3 0.594
PKCIPKCI 0.793 0.011 2 0.691
CHK2CHK2 0.793 0.038 -3 0.572
MAKMAK 0.793 0.169 -2 0.735
MRCKAMRCKA 0.793 0.126 -3 0.690
ALK2ALK2 0.792 -0.053 -2 0.772
MEKK2MEKK2 0.792 -0.046 2 0.748
MOKMOK 0.792 0.178 1 0.765
DAPK3DAPK3 0.792 0.104 -3 0.732
PAK4PAK4 0.792 0.075 -2 0.714
GRK7GRK7 0.792 -0.032 1 0.699
NEK5NEK5 0.792 -0.059 1 0.773
BMPR1ABMPR1A 0.791 0.035 1 0.690
TLK1TLK1 0.791 -0.078 -2 0.775
JNK1JNK1 0.790 0.160 1 0.698
MST3MST3 0.790 -0.033 2 0.767
MEKK3MEKK3 0.789 -0.142 1 0.763
ERK7ERK7 0.789 0.035 2 0.486
AKT3AKT3 0.789 0.080 -3 0.560
MRCKBMRCKB 0.789 0.102 -3 0.670
SBKSBK 0.789 0.059 -3 0.516
PKCEPKCE 0.788 0.033 2 0.666
MPSK1MPSK1 0.787 -0.026 1 0.714
TAO3TAO3 0.787 -0.027 1 0.750
ROCK2ROCK2 0.787 0.124 -3 0.725
SGK1SGK1 0.787 0.071 -3 0.547
IRAK1IRAK1 0.785 -0.148 -1 0.728
NEK8NEK8 0.785 -0.073 2 0.773
DAPK1DAPK1 0.785 0.078 -3 0.703
TAO2TAO2 0.784 -0.049 2 0.778
BUB1BUB1 0.784 0.069 -5 0.777
TTBK1TTBK1 0.784 -0.134 2 0.604
GRK2GRK2 0.784 -0.115 -2 0.651
PDK1PDK1 0.783 -0.049 1 0.759
MST2MST2 0.782 -0.011 1 0.767
LKB1LKB1 0.782 -0.070 -3 0.727
GAKGAK 0.782 -0.032 1 0.753
DMPK1DMPK1 0.782 0.137 -3 0.696
NEK4NEK4 0.782 -0.072 1 0.745
NEK11NEK11 0.781 -0.131 1 0.767
PKG1PKG1 0.781 0.072 -2 0.662
CAMKK1CAMKK1 0.781 -0.128 -2 0.780
MEKK6MEKK6 0.780 -0.067 1 0.753
CAMKK2CAMKK2 0.780 -0.089 -2 0.781
HGKHGK 0.780 -0.025 3 0.831
PASKPASK 0.779 -0.080 -3 0.771
MAP3K15MAP3K15 0.779 -0.047 1 0.743
LOKLOK 0.779 -0.014 -2 0.819
CK1ECK1E 0.779 -0.096 -3 0.479
GSK3BGSK3B 0.778 -0.045 4 0.378
MINKMINK 0.777 -0.037 1 0.745
GSK3AGSK3A 0.777 -0.001 4 0.384
EEF2KEEF2K 0.777 -0.053 3 0.807
GCKGCK 0.777 -0.055 1 0.746
ROCK1ROCK1 0.776 0.113 -3 0.689
NEK1NEK1 0.776 -0.069 1 0.743
RIPK2RIPK2 0.776 -0.119 1 0.738
TNIKTNIK 0.775 -0.025 3 0.833
VRK1VRK1 0.775 -0.068 2 0.808
LRRK2LRRK2 0.775 -0.108 2 0.793
CK1G1CK1G1 0.775 -0.097 -3 0.477
MST1MST1 0.774 -0.031 1 0.741
PLK2PLK2 0.774 0.014 -3 0.792
TAK1TAK1 0.773 -0.090 1 0.785
HPK1HPK1 0.773 -0.062 1 0.737
PBKPBK 0.772 -0.011 1 0.680
CRIKCRIK 0.771 0.053 -3 0.638
CK1DCK1D 0.771 -0.092 -3 0.426
MEK2MEK2 0.771 -0.145 2 0.759
YSK1YSK1 0.771 -0.056 2 0.737
KHS1KHS1 0.771 -0.021 1 0.737
SLKSLK 0.770 -0.057 -2 0.741
KHS2KHS2 0.769 -0.006 1 0.744
CK1A2CK1A2 0.769 -0.087 -3 0.425
NEK3NEK3 0.769 -0.097 1 0.740
TTKTTK 0.768 0.052 -2 0.810
GRK3GRK3 0.766 -0.129 -2 0.593
STK33STK33 0.765 -0.148 2 0.595
PDHK3_TYRPDHK3_TYR 0.764 0.089 4 0.866
CK2A2CK2A2 0.761 -0.066 1 0.600
BIKEBIKE 0.759 -0.023 1 0.639
OSR1OSR1 0.757 -0.052 2 0.734
TESK1_TYRTESK1_TYR 0.756 -0.066 3 0.860
LIMK2_TYRLIMK2_TYR 0.756 0.043 -3 0.815
MYO3BMYO3B 0.755 -0.055 2 0.759
PKMYT1_TYRPKMYT1_TYR 0.755 -0.040 3 0.833
HASPINHASPIN 0.754 -0.056 -1 0.651
TAO1TAO1 0.754 -0.071 1 0.702
MYO3AMYO3A 0.754 -0.048 1 0.729
PDHK4_TYRPDHK4_TYR 0.753 -0.015 2 0.821
ASK1ASK1 0.753 -0.112 1 0.733
MAP2K7_TYRMAP2K7_TYR 0.752 -0.162 2 0.806
MAP2K4_TYRMAP2K4_TYR 0.752 -0.145 -1 0.845
RETRET 0.752 0.013 1 0.767
CK2A1CK2A1 0.750 -0.088 1 0.576
MAP2K6_TYRMAP2K6_TYR 0.750 -0.099 -1 0.846
PINK1_TYRPINK1_TYR 0.749 -0.133 1 0.774
TYRO3TYRO3 0.749 -0.012 3 0.781
BMPR2_TYRBMPR2_TYR 0.748 -0.065 -1 0.816
ROS1ROS1 0.748 -0.002 3 0.758
ALPHAK3ALPHAK3 0.748 -0.074 -1 0.733
TNNI3K_TYRTNNI3K_TYR 0.747 0.069 1 0.808
AAK1AAK1 0.747 0.006 1 0.543
LIMK1_TYRLIMK1_TYR 0.746 -0.101 2 0.796
TYK2TYK2 0.746 -0.073 1 0.769
MST1RMST1R 0.746 -0.044 3 0.787
YANK3YANK3 0.746 -0.083 2 0.393
CSF1RCSF1R 0.746 -0.003 3 0.766
JAK2JAK2 0.745 -0.045 1 0.780
PDHK1_TYRPDHK1_TYR 0.745 -0.144 -1 0.856
EPHA6EPHA6 0.745 -0.037 -1 0.811
YES1YES1 0.745 0.013 -1 0.839
EPHB4EPHB4 0.745 -0.029 -1 0.797
TXKTXK 0.743 0.041 1 0.759
ITKITK 0.743 0.020 -1 0.781
ABL2ABL2 0.743 -0.017 -1 0.809
STLK3STLK3 0.742 -0.120 1 0.735
JAK3JAK3 0.741 -0.048 1 0.748
DDR1DDR1 0.741 -0.091 4 0.797
FGRFGR 0.740 -0.075 1 0.771
TNK1TNK1 0.739 -0.003 3 0.756
TNK2TNK2 0.739 -0.023 3 0.729
PDGFRBPDGFRB 0.739 -0.030 3 0.786
ABL1ABL1 0.739 -0.037 -1 0.806
JAK1JAK1 0.738 -0.019 1 0.729
FGFR1FGFR1 0.738 -0.023 3 0.751
SRMSSRMS 0.737 -0.046 1 0.785
LCKLCK 0.737 -0.014 -1 0.806
FGFR2FGFR2 0.736 -0.054 3 0.769
TEKTEK 0.736 -0.043 3 0.709
HCKHCK 0.736 -0.069 -1 0.810
EPHB1EPHB1 0.736 -0.055 1 0.801
BLKBLK 0.736 0.011 -1 0.822
FERFER 0.735 -0.121 1 0.800
AXLAXL 0.735 -0.049 3 0.753
NEK10_TYRNEK10_TYR 0.735 -0.089 1 0.637
KDRKDR 0.734 -0.049 3 0.739
TECTEC 0.734 -0.017 -1 0.745
INSRRINSRR 0.733 -0.093 3 0.720
KITKIT 0.733 -0.080 3 0.766
EPHB2EPHB2 0.732 -0.051 -1 0.781
BMXBMX 0.732 -0.029 -1 0.698
PDGFRAPDGFRA 0.732 -0.096 3 0.781
FLT3FLT3 0.732 -0.087 3 0.771
ALKALK 0.731 -0.045 3 0.706
BTKBTK 0.731 -0.100 -1 0.752
EPHB3EPHB3 0.731 -0.103 -1 0.783
MERTKMERTK 0.730 -0.069 3 0.746
EPHA4EPHA4 0.730 -0.101 2 0.724
DDR2DDR2 0.730 0.025 3 0.720
LTKLTK 0.729 -0.057 3 0.733
CK1ACK1A 0.729 -0.128 -3 0.344
METMET 0.729 -0.079 3 0.756
PTK2BPTK2B 0.727 -0.020 -1 0.785
FRKFRK 0.727 -0.048 -1 0.825
FYNFYN 0.726 -0.019 -1 0.783
EPHA1EPHA1 0.726 -0.074 3 0.732
PTK6PTK6 0.725 -0.115 -1 0.707
EPHA7EPHA7 0.724 -0.085 2 0.730
FLT4FLT4 0.723 -0.100 3 0.730
LYNLYN 0.723 -0.067 3 0.705
NTRK1NTRK1 0.723 -0.158 -1 0.791
WEE1_TYRWEE1_TYR 0.722 -0.112 -1 0.700
FGFR3FGFR3 0.721 -0.113 3 0.738
NTRK2NTRK2 0.721 -0.144 3 0.727
FLT1FLT1 0.719 -0.134 -1 0.782
EPHA3EPHA3 0.718 -0.159 2 0.704
INSRINSR 0.718 -0.146 3 0.699
SRCSRC 0.717 -0.067 -1 0.793
ERBB2ERBB2 0.716 -0.182 1 0.701
MATKMATK 0.715 -0.114 -1 0.726
NTRK3NTRK3 0.714 -0.152 -1 0.736
EPHA5EPHA5 0.712 -0.120 2 0.712
CK1G3CK1G3 0.712 -0.113 -3 0.299
EPHA8EPHA8 0.712 -0.107 -1 0.756
CSKCSK 0.712 -0.131 2 0.740
EGFREGFR 0.711 -0.110 1 0.631
YANK2YANK2 0.707 -0.126 2 0.397
PTK2PTK2 0.705 -0.072 -1 0.725
MUSKMUSK 0.705 -0.148 1 0.603
FGFR4FGFR4 0.705 -0.129 -1 0.737
EPHA2EPHA2 0.702 -0.112 -1 0.713
IGF1RIGF1R 0.702 -0.143 3 0.641
SYKSYK 0.699 -0.108 -1 0.714
ERBB4ERBB4 0.695 -0.119 1 0.646
FESFES 0.690 -0.154 -1 0.678
CK1G2CK1G2 0.682 -0.148 -3 0.392
ZAP70ZAP70 0.673 -0.139 -1 0.640