Motif 959 (n=209)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S282 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A6ND36 | FAM83G | S365 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| O00148 | DDX39A | S40 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O00151 | PDLIM1 | S152 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00429 | DNM1L | S40 | psp | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| O14579 | COPE | S45 | ochoa | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| O14646 | CHD1 | S1539 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14686 | KMT2D | S3229 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14802 | POLR3A | S118 | ochoa | DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160) | Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:19609254, PubMed:19631370, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:34675218, PubMed:35637192, PubMed:9331371). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Forms Pol III active center together with the second largest subunit POLR3B/RPC2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (PubMed:19609254, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33674783, PubMed:34675218, PubMed:9331371). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192, ECO:0000269|PubMed:9331371}. |
| O15164 | TRIM24 | S802 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O60318 | MCM3AP | S579 | ochoa | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}. |
| O60701 | UGDH | S216 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O60814 | H2BC12 | T91 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O60934 | NBN | S615 | ochoa|psp | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75643 | SNRNP200 | S932 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75665 | OFD1 | S723 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O76039 | CDKL5 | S394 | ochoa | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
| O94823 | ATP10B | S617 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
| P00338 | LDHA | S167 | ochoa | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P00918 | CA2 | S172 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P05181 | CYP2E1 | S431 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P07195 | LDHB | S168 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07864 | LDHC | S167 | ochoa | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | Possible role in sperm motility. |
| P09874 | PARP1 | S757 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P10586 | PTPRF | S1291 | ochoa | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| P15382 | KCNE1 | S102 | psp | Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel) (MinK) | Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:19219384, PubMed:20533308, PubMed:9230439). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization (PubMed:20533308). The outward current reaches its steady state only after 50 seconds (Probable). Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (PubMed:9230439). {ECO:0000269|PubMed:19219384, ECO:0000269|PubMed:20533308, ECO:0000269|PubMed:9230439, ECO:0000305}. |
| P18206 | VCL | S97 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19484 | TFEB | S211 | psp | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P22102 | GART | S802 | ochoa | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| P23025 | XPA | S173 | psp | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769). {ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:31253769}. |
| P23458 | JAK1 | S515 | psp | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}. |
| P28290 | ITPRID2 | S704 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29274 | ADORA2A | S374 | psp | Adenosine receptor A2a | Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| P30086 | PEBP1 | S52 | ochoa|psp | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P33527 | ABCC1 | S961 | psp | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}. |
| P35579 | MYH9 | S196 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35869 | AHR | S440 | psp | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P36956 | SREBF1 | S338 | psp | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. |
| P41743 | PRKCI | S459 | ochoa|psp | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P43005 | SLC1A1 | S476 | ochoa | Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:21123949, PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed:7914198, PubMed:8857541). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed:8857541). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:26690923, PubMed:8857541). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:33658209, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}. |
| P46060 | RANGAP1 | S506 | ochoa|psp | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P46940 | IQGAP1 | S360 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P48751 | SLC4A3 | S1121 | ochoa | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| P49327 | FASN | S1254 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49327 | FASN | S2473 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49768 | PSEN1 | S353 | ochoa|psp | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P51587 | BRCA2 | S193 | psp | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P51955 | NEK2 | S406 | psp | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P52701 | MSH6 | S668 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P52895 | AKR1C2 | S166 | ochoa | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699, ECO:0000269|PubMed:8573067}. |
| P53350 | PLK1 | S383 | ochoa|psp | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P53618 | COPB1 | S371 | ochoa | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}. |
| P54252 | ATXN3 | S265 | ochoa | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P54886 | ALDH18A1 | S79 | ochoa | Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] | Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761, ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891, ECO:0000269|PubMed:39506109}. |
| P57053 | H2BC12L | T91 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | T91 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P61925 | PKIA | S29 | ochoa | cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) | Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. |
| P62807 | H2BC4 | T91 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P63010 | AP2B1 | S258 | psp | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P78524 | DENND2B | S673 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78559 | MAP1A | S1701 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P80303 | NUCB2 | S124 | ochoa | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| Q00653 | NFKB2 | S812 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q02241 | KIF23 | S298 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q06187 | BTK | S21 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q06323 | PSME1 | S38 | ochoa | Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| Q06418 | TYRO3 | S869 | ochoa | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}. |
| Q06787 | FMR1 | S366 | ochoa | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) | Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:12417522, PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522, PubMed:30765518, PubMed:31439799). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (PubMed:30765518). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11157796, PubMed:11532944, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:11157796, PubMed:11719189, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548, PubMed:7692601). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529, PubMed:7692601). Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export (PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:12950170, PubMed:15381419, PubMed:7688265, PubMed:7781595, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (PubMed:39106863). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:11157796, ECO:0000269|PubMed:11532944, ECO:0000269|PubMed:11719189, ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:12594214, ECO:0000269|PubMed:12927206, ECO:0000269|PubMed:12950170, ECO:0000269|PubMed:14703574, ECO:0000269|PubMed:15282548, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15805463, ECO:0000269|PubMed:16631377, ECO:0000269|PubMed:17057366, ECO:0000269|PubMed:17417632, ECO:0000269|PubMed:18579868, ECO:0000269|PubMed:18653529, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:19097999, ECO:0000269|PubMed:19166269, ECO:0000269|PubMed:20512134, ECO:0000269|PubMed:23235829, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:24448548, ECO:0000269|PubMed:24813610, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:25561520, ECO:0000269|PubMed:25692235, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:31753916, ECO:0000269|PubMed:39106863, ECO:0000269|PubMed:7688265, ECO:0000269|PubMed:7692601, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8156595}.; FUNCTION: [Isoform 10]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: [Isoform 6]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components. {ECO:0000269|PubMed:24514761}. |
| Q12955 | ANK3 | S959 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13007 | IL24 | S101 | psp | Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}. |
| Q13007 | IL24 | S161 | psp | Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}. |
| Q13017 | ARHGAP5 | S590 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13023 | AKAP6 | S1329 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13393 | PLD1 | S626 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13423 | NNT | S769 | ochoa | NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase) | The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed:22634753). {ECO:0000250|UniProtKB:P07001, ECO:0000269|PubMed:22634753}. |
| Q13470 | TNK1 | S255 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q13838 | DDX39B | S41 | ochoa | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14669 | TRIP12 | S1575 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q15691 | MAPRE1 | S40 | psp | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
| Q16760 | DGKD | S66 | psp | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q16778 | H2BC21 | T91 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q16891 | IMMT | S390 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2M389 | WASHC4 | S1097 | ochoa | WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000303|PubMed:21498477}. |
| Q3V6T2 | CCDC88A | S1387 | ochoa|psp | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q53EL6 | PDCD4 | S323 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5JUK3 | KCNT1 | S407 | psp | Potassium channel subfamily T member 1 (KCa4.1) (KNa1.1) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2) | Sodium-activated K(+) channel (PubMed:37494189). Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity). Regulates neuronal bursting in sensory neurons (By similarity). Contributes to synaptic development and plasticity (By similarity). {ECO:0000250|UniProtKB:Q6ZPR4, ECO:0000250|UniProtKB:Q9Z258, ECO:0000269|PubMed:37494189}. |
| Q5QNW6 | H2BC18 | T91 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5SW79 | CEP170 | S450 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T1M5 | FKBP15 | S1018 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T4S7 | UBR4 | S652 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5TKA1 | LIN9 | S207 | ochoa | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
| Q5VYK3 | ECPAS | S833 | ochoa | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}. |
| Q641Q2 | WASHC2A | S550 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q69YH5 | CDCA2 | S853 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6DN90 | IQSEC1 | S361 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6P2E9 | EDC4 | S405 | psp | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6WKZ4 | RAB11FIP1 | S384 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6WKZ4 | RAB11FIP1 | S392 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6YHK3 | CD109 | S1129 | ochoa | CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) | Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269|PubMed:16754747}. |
| Q6ZMR3 | LDHAL6A | S167 | ochoa | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed. {ECO:0000269|PubMed:18351441}. |
| Q7Z401 | DENND4A | S895 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z7L8 | C11orf96 | S406 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86T90 | KIAA1328 | S236 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86V48 | LUZP1 | S57 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86W56 | PARG | S375 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q86XP1 | DGKH | S608 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q86XS8 | RNF130 | S341 | ochoa | E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130) | May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. {ECO:0000250, ECO:0000269|PubMed:16549277}. |
| Q8IU85 | CAMK1D | S337 | ochoa | Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| Q8IUD2 | ERC1 | S251 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IW41 | MAPKAPK5 | S354 | ochoa|psp | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8IXJ6 | SIRT2 | S53 | ochoa | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24177535, PubMed:24681946, PubMed:24769394, PubMed:24940000). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24177535, PubMed:24681946, PubMed:24769394, PubMed:24940000). Plays a major role in the control of cell cycle progression and genomic stability (PubMed:12697818, PubMed:16909107, PubMed:17488717, PubMed:17726514, PubMed:19282667, PubMed:23468428). Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes (PubMed:12697818, PubMed:16909107, PubMed:17488717, PubMed:17726514, PubMed:19282667, PubMed:23468428). Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis (PubMed:22014574). Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes (PubMed:23468428). Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis (PubMed:23468428). Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression (PubMed:23468428). Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response (PubMed:23468428). Also deacetylates histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition (PubMed:20587414). Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection (PubMed:23908241). During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function (PubMed:24940000). Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis (PubMed:24940000). Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells (PubMed:18332217, PubMed:18995842). Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation (PubMed:17488717). Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination (PubMed:21949390). Involved in several cellular metabolic pathways (PubMed:20543840, PubMed:21726808, PubMed:24769394). Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability (PubMed:21726808). Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage (PubMed:24769394). Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis (PubMed:20543840). Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity (PubMed:20543840). Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells (PubMed:20543840). Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (PubMed:20543840). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia (PubMed:24681946). Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation (PubMed:21081649). Inhibits transcriptional activation by deacetylating p53/TP53 and EP300 (PubMed:18249187, PubMed:18995842). Also deacetylates EIF5A (PubMed:22771473). Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions (PubMed:24769394). Plays a role as tumor suppressor (PubMed:22014574). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes (PubMed:25704306, PubMed:29239724, PubMed:32103017). {ECO:0000250|UniProtKB:Q8VDQ8, ECO:0000269|PubMed:12620231, ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17574768, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:18249187, ECO:0000269|PubMed:18332217, ECO:0000269|PubMed:18640115, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:19282667, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:20587414, ECO:0000269|PubMed:21081649, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:21949390, ECO:0000269|PubMed:22014574, ECO:0000269|PubMed:22771473, ECO:0000269|PubMed:22819792, ECO:0000269|PubMed:23468428, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:24177535, ECO:0000269|PubMed:24681946, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25704306, ECO:0000269|PubMed:29239724, ECO:0000269|PubMed:32103017}.; FUNCTION: [Isoform 1]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 2]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 5]: Lacks deacetylation activity, at least toward known SIRT2 targets. {ECO:0000269|PubMed:24177535}. |
| Q8N0X7 | SPART | S102 | ochoa | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:37443287, ECO:0000269|PubMed:38190532}. |
| Q8N3D4 | EHBP1L1 | S1123 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N5C8 | TAB3 | S60 | ochoa|psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8NBX0 | SCCPDH | S208 | ochoa | Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) | None |
| Q8WUM4 | PDCD6IP | S642 | ochoa | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q8WUY3 | PRUNE2 | S2439 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q92616 | GCN1 | S593 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q92796 | DLG3 | S493 | ochoa | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. |
| Q93079 | H2BC9 | T91 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96CP6 | GRAMD1A | S412 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96CT7 | CCDC124 | S194 | ochoa | Coiled-coil domain-containing protein 124 | Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage (PubMed:32687489). Also required for proper progression of late cytokinetic stages (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:32687489}. |
| Q96DN5 | TBC1D31 | S875 | ochoa | TBC1 domain family member 31 (WD repeat-containing protein 67) | Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation. {ECO:0000269|PubMed:33934390}. |
| Q96DX4 | RSPRY1 | S528 | ochoa | RING finger and SPRY domain-containing protein 1 | None |
| Q96GE4 | CEP95 | S217 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96I24 | FUBP3 | S49 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96IG2 | FBXL20 | S139 | psp | F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}. |
| Q96IT1 | ZNF496 | S188 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96K76 | USP47 | S1353 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96L93 | KIF16B | S575 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96P20 | NLRP3 | S806 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96PE3 | INPP4A | S255 | ochoa | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}. |
| Q96T37 | RBM15 | S365 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96T51 | RUFY1 | S172 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q96T58 | SPEN | S1354 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99808 | SLC29A1 | S281 | psp | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
| Q99877 | H2BC15 | T91 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | T91 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | T91 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BTT0 | ANP32E | S104 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) | Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}. |
| Q9BUB5 | MKNK1 | S39 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BWT1 | CDCA7 | S138 | ochoa | Cell division cycle-associated protein 7 (Protein JPO1) | Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269|PubMed:11598121, ECO:0000269|PubMed:15994934, ECO:0000269|PubMed:16580749, ECO:0000269|PubMed:23166294}. |
| Q9BWT3 | PAPOLG | S515 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9C0I1 | MTMR12 | S699 | ochoa | Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) | Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:11504939, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:23818870}. |
| Q9H0A8 | COMMD4 | S115 | ochoa | COMM domain-containing protein 4 | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}. |
| Q9H2P0 | ADNP | S141 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4L4 | SENP3 | S352 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H8V3 | ECT2 | S716 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9HBH9 | MKNK2 | S74 | ochoa|psp | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Q9NP74 | PALMD | S81 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NPH3 | IL1RAP | S551 | ochoa | Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3) | Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:10653850, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:12530978}.; FUNCTION: [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:19481478}. |
| Q9NR82 | KCNQ5 | S78 | ochoa | Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) | Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons (PubMed:10816588, PubMed:11159685). Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current (PubMed:10816588). Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension (PubMed:24855057). Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+) (PubMed:10816588). Similar to the native M-channel, KCNQ3-KCNQ5 potassium channel is suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10816588). {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:10816588, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:28669405}. |
| Q9NSI8 | SAMSN1 | S343 | ochoa | SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:15381729}. |
| Q9NU22 | MDN1 | S4538 | ochoa | Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) | Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}. |
| Q9NWS6 | FAM118A | S311 | ochoa | Protein FAM118A | None |
| Q9NYF8 | BCLAF1 | S559 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYQ7 | CELSR3 | S3064 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZU7 | CABP1 | S323 | psp | Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin) | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). {ECO:0000250|UniProtKB:O88751, ECO:0000250|UniProtKB:Q9JLK7, ECO:0000269|PubMed:11865310, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:15140941, ECO:0000269|PubMed:15895247, ECO:0000269|PubMed:15980432}. |
| Q9P013 | CWC15 | S24 | ochoa | Spliceosome-associated protein CWC15 homolog | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}. |
| Q9P0K7 | RAI14 | S340 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0L9 | PKD2L1 | S581 | psp | Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1) | Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:30004384). Also forms functionnal heteromeric channels with PKD1, PKD1L1 and PKD1L3 (PubMed:23212381, PubMed:24336289). Pore-forming subunit of a heterotetrameric, non-selective cation channel, formed by PKD1L2 and PKD1L3, that is permeable to sodium, potassium, magnesium and calcium and which may act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:19812697, PubMed:23212381). The homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:23212381). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). The PKD1L1:PKD2L1 complex channel is mechanosensitive only at high pressures and is highly temperature sensitive (PubMed:24336289). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1 that produces a transient increase in intracellular calcium concentration upon hypo-osmotic stimulation (200 mOsm) (By similarity). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). {ECO:0000250|UniProtKB:A2A259, ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:11959145, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:24336289, ECO:0000269|PubMed:25820328, ECO:0000269|PubMed:27754867, ECO:0000269|PubMed:29425510, ECO:0000269|PubMed:30004384}. |
| Q9P0M6 | MACROH2A2 | S341 | ochoa | Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}. |
| Q9ULH1 | ASAP1 | S1008 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9UPW0 | FOXJ3 | S489 | ochoa | Forkhead box protein J3 | Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q8BUR3}. |
| Q9UQR1 | ZNF148 | S202 | psp | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2X0 | MED16 | S326 | ochoa | Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10198638, ECO:0000269|PubMed:10235266}. |
| Q9Y426 | C2CD2 | S662 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y5S2 | CDC42BPB | S868 | ochoa|psp | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y6D5 | ARFGEF2 | S1534 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6Q9 | NCOA3 | S102 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| O43423 | ANP32CP | S100 | Sugiyama | Putative uncharacterized protein ANP32CP (Acidic leucine-rich nuclear phosphoprotein 32 family member C) (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1) | None |
| O95626 | ANP32D | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member D (Phosphoprotein 32-related protein 2) (Tumorigenic protein pp32r2) | None |
| P39687 | ANP32A | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| Q15398 | DLGAP5 | S446 | Sugiyama | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q92688 | ANP32B | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| P60228 | EIF3E | S203 | Sugiyama | Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P04040 | CAT | S254 | Sugiyama | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
| P18507 | GABRG2 | S366 | ELM | Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) (GABAAR subunit gamma-2) | Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:16412217, PubMed:23909897, PubMed:2538761, PubMed:25489750, PubMed:27864268, PubMed:29950725, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, PubMed:30602789). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:16412217, PubMed:2538761, PubMed:27864268, PubMed:29950725, PubMed:30602789). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, PubMed:25489750). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P18508, ECO:0000250|UniProtKB:P22723, ECO:0000269|PubMed:14993607, ECO:0000269|PubMed:16412217, ECO:0000269|PubMed:23909897, ECO:0000269|PubMed:2538761, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:27864268, ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789}. |
| Q99613 | EIF3C | S639 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P19429 | TNNI3 | S77 | SIGNOR|iPTMNet|EPSD | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Q96PH1 | NOX5 | S544 | SIGNOR | NADPH oxidase 5 (EC 1.6.3.-) | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516). {ECO:0000269|PubMed:12686516}.; FUNCTION: [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:11483596, PubMed:14982937, PubMed:17275676, PubMed:17587483, PubMed:21642394, PubMed:22387196, PubMed:22427510, PubMed:24505490, PubMed:36653838). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin (PubMed:17275676). Regulates redox-dependent processes in lymphocytes and spermatozoa (PubMed:11483596). {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:14982937, ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:17587483, ECO:0000269|PubMed:21642394, ECO:0000269|PubMed:22387196, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:24505490, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:21319793, ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v5]: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner (PubMed:17275676, PubMed:36653838). May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). However another study showed an absence of oxidase activity (PubMed:22427510). Subject to rapid degradation (PubMed:36653838). {ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}. |
| Q92547 | TOPBP1 | S998 | Sugiyama | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q04726 | TLE3 | S622 | Sugiyama | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| P31939 | ATIC | S370 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| O75347 | TBCA | S60 | Sugiyama | Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) | Tubulin-folding protein; involved in the early step of the tubulin folding pathway. |
| Q86U42 | PABPN1 | S225 | Sugiyama | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| P52788 | SMS | S57 | Sugiyama | Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase) | Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). {ECO:0000269|PubMed:18367445, ECO:0000269|PubMed:18550699, ECO:0000269|PubMed:23696453, ECO:0000269|PubMed:23897707}. |
| Q13422 | IKZF1 | S101 | SIGNOR | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q8TF05 | PPP4R1 | S547 | Sugiyama | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}. |
| Q16222 | UAP1 | S496 | Sugiyama | UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23) | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579). {ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:9603950, ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). {ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). {ECO:0000269|PubMed:9765219}. |
| P33176 | KIF5B | S443 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| Q9Y5J9 | TIMM8B | S57 | Sugiyama | Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2) | Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). {ECO:0000250}. |
| Q13164 | MAPK7 | Y172 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| P62081 | RPS7 | S137 | Sugiyama | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q14191 | WRN | S1292 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q9H078 | CLPB | S155 | Sugiyama | Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842). {ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32573439, ECO:0000269|PubMed:34115842, ECO:0000269|PubMed:35247700, ECO:0000269|PubMed:36170828, ECO:0000269|PubMed:36745679}. |
| P22061 | PCMT1 | S119 | Sugiyama | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250|UniProtKB:P23506, ECO:0000269|PubMed:3167043, ECO:0000269|PubMed:6469980}. |
| Q02818 | NUCB1 | S378 | Sugiyama | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q9H0H5 | RACGAP1 | S410 | ELM|iPTMNet|EPSD | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q96J92 | WNK4 | S316 | Sugiyama | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
| P62191 | PSMC1 | S244 | Sugiyama | 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| Q08378 | GOLGA3 | S1036 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| O15397 | IPO8 | S29 | Sugiyama | Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) | Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382, ECO:0000305|PubMed:34010604}. |
| Q14524 | SCN5A | S1925 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q9BYP7 | WNK3 | S289 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9H4A3 | WNK1 | S363 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9Y3S1 | WNK2 | S337 | Sugiyama | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y572 | RIPK3 | S199 | GPS6|EPSD | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| P15924 | DSP | S63 | Sugiyama | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-171306 | Packaging Of Telomere Ends | 9.216150e-11 | 10.035 |
| R-HSA-912446 | Meiotic recombination | 1.111143e-10 | 9.954 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 9.216150e-11 | 10.035 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.689760e-11 | 10.433 |
| R-HSA-5334118 | DNA methylation | 1.618731e-10 | 9.791 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.904934e-10 | 9.408 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.728100e-10 | 9.429 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.547795e-10 | 9.450 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.542681e-10 | 9.343 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 6.605823e-10 | 9.180 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 7.304534e-10 | 9.136 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 7.304534e-10 | 9.136 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 9.895795e-10 | 9.005 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 9.609676e-10 | 9.017 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.146905e-09 | 8.940 |
| R-HSA-5693538 | Homology Directed Repair | 1.482927e-09 | 8.829 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.425328e-09 | 8.846 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.425328e-09 | 8.846 |
| R-HSA-73927 | Depurination | 1.762214e-09 | 8.754 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.654628e-09 | 8.576 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.654628e-09 | 8.576 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.235815e-09 | 8.490 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.235815e-09 | 8.490 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.746407e-09 | 8.324 |
| R-HSA-73928 | Depyrimidination | 4.746407e-09 | 8.324 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.014877e-09 | 8.221 |
| R-HSA-9710421 | Defective pyroptosis | 5.713654e-09 | 8.243 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.975821e-09 | 8.156 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 8.185898e-09 | 8.087 |
| R-HSA-774815 | Nucleosome assembly | 8.185898e-09 | 8.087 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 9.376897e-09 | 8.028 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.040126e-08 | 7.983 |
| R-HSA-1500620 | Meiosis | 1.700629e-08 | 7.769 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.642992e-08 | 7.784 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.880561e-08 | 7.726 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.148277e-08 | 7.668 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.592178e-08 | 7.586 |
| R-HSA-1221632 | Meiotic synapsis | 3.019960e-08 | 7.520 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.019960e-08 | 7.520 |
| R-HSA-69481 | G2/M Checkpoints | 3.036011e-08 | 7.518 |
| R-HSA-73884 | Base Excision Repair | 3.338134e-08 | 7.476 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.591221e-08 | 7.445 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.508897e-08 | 7.455 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.066403e-08 | 7.391 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.389468e-08 | 7.358 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 8.197009e-08 | 7.086 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 8.197009e-08 | 7.086 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.068203e-07 | 6.971 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.156689e-07 | 6.937 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.436407e-07 | 6.843 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.872886e-07 | 6.727 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.872886e-07 | 6.727 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.872886e-07 | 6.727 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.803448e-07 | 6.744 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.803448e-07 | 6.744 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.781398e-07 | 6.749 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.414134e-07 | 6.617 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.851420e-07 | 6.545 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.851420e-07 | 6.545 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.198474e-07 | 6.495 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 3.198474e-07 | 6.495 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.249915e-07 | 6.488 |
| R-HSA-157118 | Signaling by NOTCH | 3.453585e-07 | 6.462 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.331951e-07 | 6.363 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.549508e-07 | 6.256 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.848013e-07 | 6.164 |
| R-HSA-157579 | Telomere Maintenance | 6.851903e-07 | 6.164 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 8.404787e-07 | 6.075 |
| R-HSA-977225 | Amyloid fiber formation | 9.293099e-07 | 6.032 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.034979e-06 | 5.985 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.058512e-06 | 5.975 |
| R-HSA-211000 | Gene Silencing by RNA | 1.734117e-06 | 5.761 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.814983e-06 | 5.741 |
| R-HSA-1474165 | Reproduction | 1.951562e-06 | 5.710 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.031325e-06 | 5.692 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.762559e-06 | 5.559 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.372259e-06 | 5.472 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.055609e-06 | 5.392 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.927447e-06 | 5.307 |
| R-HSA-68875 | Mitotic Prophase | 5.300712e-06 | 5.276 |
| R-HSA-73886 | Chromosome Maintenance | 5.680632e-06 | 5.246 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.889799e-06 | 5.230 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.889799e-06 | 5.230 |
| R-HSA-3214847 | HATs acetylate histones | 5.943570e-06 | 5.226 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.512383e-06 | 5.186 |
| R-HSA-8939211 | ESR-mediated signaling | 6.645541e-06 | 5.177 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.492273e-06 | 5.125 |
| R-HSA-2559583 | Cellular Senescence | 8.587269e-06 | 5.066 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.004316e-05 | 4.998 |
| R-HSA-73894 | DNA Repair | 1.352318e-05 | 4.869 |
| R-HSA-5688426 | Deubiquitination | 1.460162e-05 | 4.836 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.917277e-05 | 4.717 |
| R-HSA-68886 | M Phase | 2.907454e-05 | 4.536 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.924125e-05 | 4.534 |
| R-HSA-8852135 | Protein ubiquitination | 3.406231e-05 | 4.468 |
| R-HSA-69306 | DNA Replication | 4.869432e-05 | 4.313 |
| R-HSA-421270 | Cell-cell junction organization | 5.036736e-05 | 4.298 |
| R-HSA-418990 | Adherens junctions interactions | 5.375198e-05 | 4.270 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.107256e-05 | 4.214 |
| R-HSA-1640170 | Cell Cycle | 6.684481e-05 | 4.175 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.225894e-04 | 3.912 |
| R-HSA-446728 | Cell junction organization | 1.353246e-04 | 3.869 |
| R-HSA-1500931 | Cell-Cell communication | 1.361028e-04 | 3.866 |
| R-HSA-195721 | Signaling by WNT | 2.609887e-04 | 3.583 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.902710e-04 | 3.537 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.854721e-04 | 3.414 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.971859e-04 | 3.401 |
| R-HSA-4839726 | Chromatin organization | 6.358255e-04 | 3.197 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 8.054403e-04 | 3.094 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.049620e-03 | 2.979 |
| R-HSA-9610379 | HCMV Late Events | 1.146759e-03 | 2.941 |
| R-HSA-9675135 | Diseases of DNA repair | 1.235396e-03 | 2.908 |
| R-HSA-9609690 | HCMV Early Events | 1.308540e-03 | 2.883 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.658902e-03 | 2.780 |
| R-HSA-162582 | Signal Transduction | 1.577117e-03 | 2.802 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.798916e-03 | 2.745 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.043130e-03 | 2.690 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.167617e-03 | 2.499 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.167617e-03 | 2.499 |
| R-HSA-983189 | Kinesins | 3.326662e-03 | 2.478 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.449417e-03 | 2.462 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.396090e-03 | 2.357 |
| R-HSA-156711 | Polo-like kinase mediated events | 4.748982e-03 | 2.323 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 5.339167e-03 | 2.273 |
| R-HSA-844456 | The NLRP3 inflammasome | 5.339167e-03 | 2.273 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 5.971534e-03 | 2.224 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.971534e-03 | 2.224 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.971534e-03 | 2.224 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 5.971534e-03 | 2.224 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.213438e-03 | 2.207 |
| R-HSA-9609646 | HCMV Infection | 6.472957e-03 | 2.189 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.068999e-02 | 1.971 |
| R-HSA-1280218 | Adaptive Immune System | 1.236394e-02 | 1.908 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.339273e-02 | 1.873 |
| R-HSA-622312 | Inflammasomes | 1.366744e-02 | 1.864 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.383068e-02 | 1.859 |
| R-HSA-5689877 | Josephin domain DUBs | 1.557043e-02 | 1.808 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.588842e-02 | 1.799 |
| R-HSA-2262752 | Cellular responses to stress | 1.650011e-02 | 1.783 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.788883e-02 | 1.747 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.911779e-02 | 1.719 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.957836e-02 | 1.708 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.957836e-02 | 1.708 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.034348e-02 | 1.692 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.034348e-02 | 1.692 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.042790e-02 | 1.690 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.042790e-02 | 1.690 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.042790e-02 | 1.690 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.090447e-02 | 1.680 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.233235e-02 | 1.651 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.332384e-02 | 1.632 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.434171e-02 | 1.614 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.136709e-02 | 1.670 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.277543e-02 | 1.643 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 2.564421e-02 | 1.591 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.669060e-02 | 1.574 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.852574e-02 | 1.545 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.852574e-02 | 1.545 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 2.852574e-02 | 1.545 |
| R-HSA-69275 | G2/M Transition | 3.089149e-02 | 1.510 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.100969e-02 | 1.509 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.141702e-02 | 1.503 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.143888e-02 | 1.503 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.229376e-02 | 1.491 |
| R-HSA-380287 | Centrosome maturation | 3.344833e-02 | 1.476 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 3.451132e-02 | 1.462 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.500203e-02 | 1.456 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 3.599590e-02 | 1.444 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.865274e-02 | 1.413 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.577374e-02 | 1.339 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.449170e-02 | 1.352 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.449170e-02 | 1.352 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.449170e-02 | 1.352 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 4.248329e-02 | 1.372 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 4.248329e-02 | 1.372 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.449170e-02 | 1.352 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 4.438254e-02 | 1.353 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.449170e-02 | 1.352 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.449170e-02 | 1.352 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.449170e-02 | 1.352 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 4.438254e-02 | 1.353 |
| R-HSA-1483148 | Synthesis of PG | 3.769527e-02 | 1.424 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.160450e-02 | 1.381 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.727998e-02 | 1.325 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.727998e-02 | 1.325 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.030647e-02 | 1.298 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.037429e-02 | 1.298 |
| R-HSA-70268 | Pyruvate metabolism | 5.196227e-02 | 1.284 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.357737e-02 | 1.271 |
| R-HSA-198765 | Signalling to ERK5 | 5.624115e-02 | 1.250 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 5.624115e-02 | 1.250 |
| R-HSA-9014843 | Interleukin-33 signaling | 5.624115e-02 | 1.250 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.688872e-02 | 1.245 |
| R-HSA-72187 | mRNA 3'-end processing | 5.738263e-02 | 1.241 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 5.893329e-02 | 1.230 |
| R-HSA-72649 | Translation initiation complex formation | 6.203074e-02 | 1.207 |
| R-HSA-8854691 | Interleukin-20 family signaling | 6.674177e-02 | 1.176 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.684848e-02 | 1.175 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.684848e-02 | 1.175 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 6.980218e-02 | 1.156 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 6.980218e-02 | 1.156 |
| R-HSA-417973 | Adenosine P1 receptors | 6.980218e-02 | 1.156 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 6.980218e-02 | 1.156 |
| R-HSA-9824446 | Viral Infection Pathways | 7.182334e-02 | 1.144 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 7.183197e-02 | 1.144 |
| R-HSA-5619067 | Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic ami... | 9.634488e-02 | 1.016 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 1.093320e-01 | 0.961 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.093320e-01 | 0.961 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.347515e-01 | 0.870 |
| R-HSA-9020958 | Interleukin-21 signaling | 1.594484e-01 | 0.797 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.715324e-01 | 0.766 |
| R-HSA-202670 | ERKs are inactivated | 1.951839e-01 | 0.710 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 8.329666e-02 | 1.079 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.294063e-01 | 0.639 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 2.404887e-01 | 0.619 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 2.404887e-01 | 0.619 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.195112e-01 | 0.923 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.621795e-01 | 0.581 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.832535e-01 | 0.548 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.565028e-01 | 0.805 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.565028e-01 | 0.805 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.992794e-01 | 0.701 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.521306e-01 | 0.598 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.388387e-01 | 0.857 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.067563e-01 | 0.685 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.093320e-01 | 0.961 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.487424e-01 | 0.828 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.951839e-01 | 0.710 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.792161e-01 | 0.747 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.101233e-01 | 0.958 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 1.347515e-01 | 0.870 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.067563e-01 | 0.685 |
| R-HSA-211981 | Xenobiotics | 2.796456e-01 | 0.553 |
| R-HSA-4641265 | Repression of WNT target genes | 2.067563e-01 | 0.685 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 2.181630e-01 | 0.661 |
| R-HSA-1059683 | Interleukin-6 signaling | 2.181630e-01 | 0.661 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.727925e-01 | 0.564 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.537468e-01 | 0.813 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.210866e-01 | 0.655 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.210866e-01 | 0.655 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.834434e-01 | 0.736 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 8.316916e-02 | 1.080 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.347515e-01 | 0.870 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.621795e-01 | 0.581 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.029657e-01 | 0.693 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.029657e-01 | 0.693 |
| R-HSA-8984722 | Interleukin-35 Signalling | 2.067563e-01 | 0.685 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.587836e-01 | 0.799 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.178642e-01 | 0.662 |
| R-HSA-68877 | Mitotic Prometaphase | 1.951371e-01 | 0.710 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.910253e-01 | 0.536 |
| R-HSA-8985947 | Interleukin-9 signaling | 1.471890e-01 | 0.832 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.910253e-01 | 0.536 |
| R-HSA-187024 | NGF-independant TRKA activation | 1.093320e-01 | 0.961 |
| R-HSA-176417 | Phosphorylation of Emi1 | 1.093320e-01 | 0.961 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 1.093320e-01 | 0.961 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.715324e-01 | 0.766 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.715324e-01 | 0.766 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.834434e-01 | 0.736 |
| R-HSA-177135 | Conjugation of benzoate with glycine | 1.834434e-01 | 0.736 |
| R-HSA-192814 | vRNA Synthesis | 1.834434e-01 | 0.736 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.067563e-01 | 0.685 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.067563e-01 | 0.685 |
| R-HSA-177128 | Conjugation of salicylate with glycine | 2.067563e-01 | 0.685 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.181630e-01 | 0.661 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.404887e-01 | 0.619 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.514123e-01 | 0.600 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.960901e-02 | 1.099 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.227972e-02 | 1.085 |
| R-HSA-9020956 | Interleukin-27 signaling | 1.715324e-01 | 0.766 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.347515e-01 | 0.870 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 2.621795e-01 | 0.581 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.832535e-01 | 0.548 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.530779e-01 | 0.815 |
| R-HSA-5358508 | Mismatch Repair | 2.832535e-01 | 0.548 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.594484e-01 | 0.797 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.715324e-01 | 0.766 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.294063e-01 | 0.639 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.514123e-01 | 0.600 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.727925e-01 | 0.564 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.559890e-01 | 0.592 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.316895e-01 | 0.635 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.708288e-01 | 0.567 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.287274e-01 | 0.890 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.287274e-01 | 0.890 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.363395e-01 | 0.865 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.339436e-01 | 0.873 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.487424e-01 | 0.828 |
| R-HSA-5260271 | Diseases of Immune System | 1.487424e-01 | 0.828 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.363395e-01 | 0.865 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.099715e-02 | 1.092 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 8.316916e-02 | 1.080 |
| R-HSA-9014826 | Interleukin-36 pathway | 9.634488e-02 | 1.016 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.347515e-01 | 0.870 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 1.471890e-01 | 0.832 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.594484e-01 | 0.797 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.404887e-01 | 0.619 |
| R-HSA-5576893 | Phase 2 - plateau phase | 2.621795e-01 | 0.581 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.621795e-01 | 0.581 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.832535e-01 | 0.548 |
| R-HSA-159424 | Conjugation of carboxylic acids | 2.935646e-01 | 0.532 |
| R-HSA-156587 | Amino Acid conjugation | 2.935646e-01 | 0.532 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.935646e-01 | 0.532 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.521306e-01 | 0.598 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.079695e-01 | 0.967 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.079695e-01 | 0.967 |
| R-HSA-5617833 | Cilium Assembly | 1.877160e-01 | 0.726 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 7.487105e-02 | 1.126 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 1.537468e-01 | 0.813 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.895781e-01 | 0.722 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.506664e-02 | 1.022 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.594484e-01 | 0.797 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.437724e-01 | 0.842 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.437724e-01 | 0.842 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.792161e-01 | 0.747 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.792161e-01 | 0.747 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.704338e-01 | 0.768 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.783391e-02 | 1.056 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.029657e-01 | 0.693 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 7.904830e-02 | 1.102 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.634233e-01 | 0.787 |
| R-HSA-447038 | NrCAM interactions | 9.634488e-02 | 1.016 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.221334e-01 | 0.913 |
| R-HSA-187015 | Activation of TRKA receptors | 1.347515e-01 | 0.870 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.715324e-01 | 0.766 |
| R-HSA-425381 | Bicarbonate transporters | 1.834434e-01 | 0.736 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.727925e-01 | 0.564 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 2.935646e-01 | 0.532 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.332525e-01 | 0.632 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.576311e-02 | 1.019 |
| R-HSA-9907900 | Proteasome assembly | 1.740689e-01 | 0.759 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 9.643989e-02 | 1.016 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.895781e-01 | 0.722 |
| R-HSA-373760 | L1CAM interactions | 1.213007e-01 | 0.916 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.521306e-01 | 0.598 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 2.935646e-01 | 0.532 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.604680e-01 | 0.584 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.576311e-02 | 1.019 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.024536e-01 | 0.989 |
| R-HSA-8956320 | Nucleotide biosynthesis | 2.210866e-01 | 0.655 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.024536e-01 | 0.989 |
| R-HSA-168256 | Immune System | 2.920280e-01 | 0.535 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 9.142187e-02 | 1.039 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.634488e-02 | 1.016 |
| R-HSA-448706 | Interleukin-1 processing | 1.594484e-01 | 0.797 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.594484e-01 | 0.797 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.594484e-01 | 0.797 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.834434e-01 | 0.736 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 1.834434e-01 | 0.736 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.294063e-01 | 0.639 |
| R-HSA-9930044 | Nuclear RNA decay | 1.101233e-01 | 0.958 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.565028e-01 | 0.805 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.521306e-01 | 0.598 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.423238e-01 | 0.616 |
| R-HSA-450294 | MAP kinase activation | 2.636453e-01 | 0.579 |
| R-HSA-68882 | Mitotic Anaphase | 2.577544e-01 | 0.589 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.103854e-01 | 0.677 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.901781e-01 | 0.721 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.103854e-01 | 0.677 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.103854e-01 | 0.677 |
| R-HSA-199991 | Membrane Trafficking | 2.643576e-01 | 0.578 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.537468e-01 | 0.813 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.559890e-01 | 0.592 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.067563e-01 | 0.685 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.621795e-01 | 0.581 |
| R-HSA-9753281 | Paracetamol ADME | 2.316895e-01 | 0.635 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.714998e-01 | 0.566 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 2.689797e-01 | 0.570 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.832002e-01 | 0.548 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.912463e-01 | 0.536 |
| R-HSA-1989781 | PPARA activates gene expression | 1.081646e-01 | 0.966 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.444408e-01 | 0.612 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.294063e-01 | 0.639 |
| R-HSA-5676934 | Protein repair | 2.404887e-01 | 0.619 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.689797e-01 | 0.570 |
| R-HSA-5357801 | Programmed Cell Death | 2.284055e-01 | 0.641 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.120616e-01 | 0.951 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.514123e-01 | 0.600 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.743135e-01 | 0.562 |
| R-HSA-983712 | Ion channel transport | 8.357676e-02 | 1.078 |
| R-HSA-351202 | Metabolism of polyamines | 2.583113e-01 | 0.588 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.537468e-01 | 0.813 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.522901e-01 | 0.817 |
| R-HSA-392499 | Metabolism of proteins | 2.661685e-01 | 0.575 |
| R-HSA-9758890 | Transport of RCbl within the body | 1.834434e-01 | 0.736 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.834434e-01 | 0.736 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.067563e-01 | 0.685 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.147923e-01 | 0.940 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.935646e-01 | 0.532 |
| R-HSA-9833110 | RSV-host interactions | 2.367903e-01 | 0.626 |
| R-HSA-597592 | Post-translational protein modification | 1.828777e-01 | 0.738 |
| R-HSA-1483255 | PI Metabolism | 2.253976e-01 | 0.647 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.471890e-01 | 0.832 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.727925e-01 | 0.564 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.049751e-01 | 0.979 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.158002e-01 | 0.666 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.388387e-01 | 0.857 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.404887e-01 | 0.619 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.234245e-01 | 0.909 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.242776e-01 | 0.906 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.141177e-01 | 0.669 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.404887e-01 | 0.619 |
| R-HSA-9909396 | Circadian clock | 1.684974e-01 | 0.773 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 1.147923e-01 | 0.940 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 2.832535e-01 | 0.548 |
| R-HSA-449836 | Other interleukin signaling | 2.935646e-01 | 0.532 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 2.370034e-01 | 0.625 |
| R-HSA-1483166 | Synthesis of PA | 2.423238e-01 | 0.616 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.269386e-01 | 0.896 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.847055e-01 | 0.734 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.301798e-01 | 0.638 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 8.329666e-02 | 1.079 |
| R-HSA-73887 | Death Receptor Signaling | 2.394278e-01 | 0.621 |
| R-HSA-75153 | Apoptotic execution phase | 1.843864e-01 | 0.734 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.849748e-01 | 0.545 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.581726e-01 | 0.588 |
| R-HSA-5218859 | Regulated Necrosis | 3.009360e-01 | 0.522 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.009360e-01 | 0.522 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.037280e-01 | 0.518 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.037280e-01 | 0.518 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.037280e-01 | 0.518 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.037280e-01 | 0.518 |
| R-HSA-373753 | Nephrin family interactions | 3.037280e-01 | 0.518 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.061315e-01 | 0.514 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.062443e-01 | 0.514 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.087310e-01 | 0.510 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.106477e-01 | 0.508 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.106477e-01 | 0.508 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.115451e-01 | 0.506 |
| R-HSA-448424 | Interleukin-17 signaling | 3.115451e-01 | 0.506 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.115451e-01 | 0.506 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.137458e-01 | 0.503 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.137458e-01 | 0.503 |
| R-HSA-198753 | ERK/MAPK targets | 3.137458e-01 | 0.503 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.137458e-01 | 0.503 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.137458e-01 | 0.503 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.137458e-01 | 0.503 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.221204e-01 | 0.492 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.221204e-01 | 0.492 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.224441e-01 | 0.492 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.236201e-01 | 0.490 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.236201e-01 | 0.490 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.236201e-01 | 0.490 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.236201e-01 | 0.490 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.236201e-01 | 0.490 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.236201e-01 | 0.490 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.236201e-01 | 0.490 |
| R-HSA-9755088 | Ribavirin ADME | 3.236201e-01 | 0.490 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.236201e-01 | 0.490 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.273933e-01 | 0.485 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.273933e-01 | 0.485 |
| R-HSA-9749641 | Aspirin ADME | 3.273933e-01 | 0.485 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.326553e-01 | 0.478 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.326553e-01 | 0.478 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.333530e-01 | 0.477 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.333530e-01 | 0.477 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.333530e-01 | 0.477 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.333530e-01 | 0.477 |
| R-HSA-8964038 | LDL clearance | 3.333530e-01 | 0.477 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.333530e-01 | 0.477 |
| R-HSA-1266738 | Developmental Biology | 3.351282e-01 | 0.475 |
| R-HSA-114608 | Platelet degranulation | 3.381755e-01 | 0.471 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.421061e-01 | 0.466 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.429463e-01 | 0.465 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.429463e-01 | 0.465 |
| R-HSA-9018682 | Biosynthesis of maresins | 3.429463e-01 | 0.465 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 3.429463e-01 | 0.465 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.431434e-01 | 0.465 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.512356e-01 | 0.454 |
| R-HSA-211999 | CYP2E1 reactions | 3.524022e-01 | 0.453 |
| R-HSA-6783589 | Interleukin-6 family signaling | 3.524022e-01 | 0.453 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.524022e-01 | 0.453 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.524022e-01 | 0.453 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.535790e-01 | 0.452 |
| R-HSA-4086400 | PCP/CE pathway | 3.535790e-01 | 0.452 |
| R-HSA-9843745 | Adipogenesis | 3.578082e-01 | 0.446 |
| R-HSA-5576891 | Cardiac conduction | 3.578082e-01 | 0.446 |
| R-HSA-9659379 | Sensory processing of sound | 3.587753e-01 | 0.445 |
| R-HSA-9620244 | Long-term potentiation | 3.617226e-01 | 0.442 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.617226e-01 | 0.442 |
| R-HSA-420029 | Tight junction interactions | 3.617226e-01 | 0.442 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.617226e-01 | 0.442 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.639564e-01 | 0.439 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.656417e-01 | 0.437 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.685914e-01 | 0.433 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.697733e-01 | 0.432 |
| R-HSA-3295583 | TRP channels | 3.709094e-01 | 0.431 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.709094e-01 | 0.431 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.709094e-01 | 0.431 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.709094e-01 | 0.431 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.709094e-01 | 0.431 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.709094e-01 | 0.431 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.709094e-01 | 0.431 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.727832e-01 | 0.429 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.742705e-01 | 0.427 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.794023e-01 | 0.421 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 3.794023e-01 | 0.421 |
| R-HSA-8949613 | Cristae formation | 3.799645e-01 | 0.420 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.799645e-01 | 0.420 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 3.799645e-01 | 0.420 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.799645e-01 | 0.420 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.799645e-01 | 0.420 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.799645e-01 | 0.420 |
| R-HSA-264876 | Insulin processing | 3.799645e-01 | 0.420 |
| R-HSA-8957322 | Metabolism of steroids | 3.800342e-01 | 0.420 |
| R-HSA-163685 | Integration of energy metabolism | 3.812593e-01 | 0.419 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.845165e-01 | 0.415 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.851514e-01 | 0.414 |
| R-HSA-6798695 | Neutrophil degranulation | 3.886238e-01 | 0.410 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.888899e-01 | 0.410 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 3.888899e-01 | 0.410 |
| R-HSA-77387 | Insulin receptor recycling | 3.888899e-01 | 0.410 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.888899e-01 | 0.410 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.946898e-01 | 0.404 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.976873e-01 | 0.400 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.976873e-01 | 0.400 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.976873e-01 | 0.400 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.063586e-01 | 0.391 |
| R-HSA-2424491 | DAP12 signaling | 4.063586e-01 | 0.391 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.083760e-01 | 0.389 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.149056e-01 | 0.382 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.149056e-01 | 0.382 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.149056e-01 | 0.382 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.149056e-01 | 0.382 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.211058e-01 | 0.376 |
| R-HSA-1538133 | G0 and Early G1 | 4.233301e-01 | 0.373 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.233301e-01 | 0.373 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.233301e-01 | 0.373 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.233301e-01 | 0.373 |
| R-HSA-212436 | Generic Transcription Pathway | 4.238702e-01 | 0.373 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.275288e-01 | 0.369 |
| R-HSA-5663205 | Infectious disease | 4.277829e-01 | 0.369 |
| R-HSA-166520 | Signaling by NTRKs | 4.313341e-01 | 0.365 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.316337e-01 | 0.365 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.316337e-01 | 0.365 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.316337e-01 | 0.365 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.316337e-01 | 0.365 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.316337e-01 | 0.365 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.316337e-01 | 0.365 |
| R-HSA-397014 | Muscle contraction | 4.327625e-01 | 0.364 |
| R-HSA-422475 | Axon guidance | 4.343685e-01 | 0.362 |
| R-HSA-74160 | Gene expression (Transcription) | 4.344722e-01 | 0.362 |
| R-HSA-391251 | Protein folding | 4.345774e-01 | 0.362 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.352349e-01 | 0.361 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.389171e-01 | 0.358 |
| R-HSA-390522 | Striated Muscle Contraction | 4.398184e-01 | 0.357 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.398184e-01 | 0.357 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.398184e-01 | 0.357 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 4.398184e-01 | 0.357 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.398184e-01 | 0.357 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.398184e-01 | 0.357 |
| R-HSA-189483 | Heme degradation | 4.398184e-01 | 0.357 |
| R-HSA-9658195 | Leishmania infection | 4.408668e-01 | 0.356 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.408668e-01 | 0.356 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.436780e-01 | 0.353 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.464620e-01 | 0.350 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.478856e-01 | 0.349 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.478856e-01 | 0.349 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.478856e-01 | 0.349 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4.478856e-01 | 0.349 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.478856e-01 | 0.349 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.478856e-01 | 0.349 |
| R-HSA-9748784 | Drug ADME | 4.518898e-01 | 0.345 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.558372e-01 | 0.341 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.558372e-01 | 0.341 |
| R-HSA-169911 | Regulation of Apoptosis | 4.558372e-01 | 0.341 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 4.558372e-01 | 0.341 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.558372e-01 | 0.341 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.636747e-01 | 0.334 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.636747e-01 | 0.334 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.636747e-01 | 0.334 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.636747e-01 | 0.334 |
| R-HSA-69205 | G1/S-Specific Transcription | 4.636747e-01 | 0.334 |
| R-HSA-8853659 | RET signaling | 4.636747e-01 | 0.334 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.682978e-01 | 0.329 |
| R-HSA-1296072 | Voltage gated Potassium channels | 4.713998e-01 | 0.327 |
| R-HSA-4641258 | Degradation of DVL | 4.713998e-01 | 0.327 |
| R-HSA-4641257 | Degradation of AXIN | 4.713998e-01 | 0.327 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.713998e-01 | 0.327 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 4.713998e-01 | 0.327 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.777123e-01 | 0.321 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.777123e-01 | 0.321 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.790141e-01 | 0.320 |
| R-HSA-1483257 | Phospholipid metabolism | 4.798778e-01 | 0.319 |
| R-HSA-162906 | HIV Infection | 4.801790e-01 | 0.319 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.832885e-01 | 0.316 |
| R-HSA-109581 | Apoptosis | 4.835473e-01 | 0.316 |
| R-HSA-382551 | Transport of small molecules | 4.838974e-01 | 0.315 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.865193e-01 | 0.313 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.865193e-01 | 0.313 |
| R-HSA-69541 | Stabilization of p53 | 4.865193e-01 | 0.313 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.939167e-01 | 0.306 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.939167e-01 | 0.306 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.939167e-01 | 0.306 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.939167e-01 | 0.306 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.939167e-01 | 0.306 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.962340e-01 | 0.304 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.962340e-01 | 0.304 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.012080e-01 | 0.300 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.012080e-01 | 0.300 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.053377e-01 | 0.296 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.083948e-01 | 0.294 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.083948e-01 | 0.294 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.083948e-01 | 0.294 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.083948e-01 | 0.294 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.083948e-01 | 0.294 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.083948e-01 | 0.294 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.083948e-01 | 0.294 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.083948e-01 | 0.294 |
| R-HSA-9675108 | Nervous system development | 5.094785e-01 | 0.293 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.154784e-01 | 0.288 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.154784e-01 | 0.288 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.194195e-01 | 0.284 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.224603e-01 | 0.282 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.224603e-01 | 0.282 |
| R-HSA-2172127 | DAP12 interactions | 5.293421e-01 | 0.276 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.293421e-01 | 0.276 |
| R-HSA-5683826 | Surfactant metabolism | 5.293421e-01 | 0.276 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 5.293421e-01 | 0.276 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 5.293421e-01 | 0.276 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.333901e-01 | 0.273 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.361252e-01 | 0.271 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.361252e-01 | 0.271 |
| R-HSA-9824272 | Somitogenesis | 5.361252e-01 | 0.271 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.361252e-01 | 0.271 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.408615e-01 | 0.267 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.428109e-01 | 0.265 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.428109e-01 | 0.265 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.428109e-01 | 0.265 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.428109e-01 | 0.265 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.428109e-01 | 0.265 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.449643e-01 | 0.264 |
| R-HSA-1643685 | Disease | 5.470492e-01 | 0.262 |
| R-HSA-168255 | Influenza Infection | 5.471308e-01 | 0.262 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.492293e-01 | 0.260 |
| R-HSA-437239 | Recycling pathway of L1 | 5.494006e-01 | 0.260 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 5.494006e-01 | 0.260 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 5.576750e-01 | 0.254 |
| R-HSA-9766229 | Degradation of CDH1 | 5.622977e-01 | 0.250 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.622977e-01 | 0.250 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.622977e-01 | 0.250 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.622977e-01 | 0.250 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.622977e-01 | 0.250 |
| R-HSA-112316 | Neuronal System | 5.639275e-01 | 0.249 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.660083e-01 | 0.247 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 5.686077e-01 | 0.245 |
| R-HSA-9748787 | Azathioprine ADME | 5.686077e-01 | 0.245 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.748272e-01 | 0.240 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.748272e-01 | 0.240 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.748272e-01 | 0.240 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.809574e-01 | 0.236 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.809574e-01 | 0.236 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.809574e-01 | 0.236 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.809574e-01 | 0.236 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.809574e-01 | 0.236 |
| R-HSA-168249 | Innate Immune System | 5.843213e-01 | 0.233 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.869995e-01 | 0.231 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.869995e-01 | 0.231 |
| R-HSA-416476 | G alpha (q) signalling events | 5.894615e-01 | 0.230 |
| R-HSA-449147 | Signaling by Interleukins | 5.926238e-01 | 0.227 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.929549e-01 | 0.227 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.929549e-01 | 0.227 |
| R-HSA-156588 | Glucuronidation | 5.929549e-01 | 0.227 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.964919e-01 | 0.224 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 6.001213e-01 | 0.222 |
| R-HSA-69206 | G1/S Transition | 6.021048e-01 | 0.220 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.046104e-01 | 0.219 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.046104e-01 | 0.219 |
| R-HSA-5578775 | Ion homeostasis | 6.046104e-01 | 0.219 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.046104e-01 | 0.219 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.046104e-01 | 0.219 |
| R-HSA-75893 | TNF signaling | 6.046104e-01 | 0.219 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.103129e-01 | 0.214 |
| R-HSA-6782135 | Dual incision in TC-NER | 6.159336e-01 | 0.210 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.213508e-01 | 0.207 |
| R-HSA-9033241 | Peroxisomal protein import | 6.214735e-01 | 0.207 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.214735e-01 | 0.207 |
| R-HSA-180786 | Extension of Telomeres | 6.214735e-01 | 0.207 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.243843e-01 | 0.205 |
| R-HSA-977443 | GABA receptor activation | 6.269338e-01 | 0.203 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.269338e-01 | 0.203 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.269338e-01 | 0.203 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.269338e-01 | 0.203 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.269338e-01 | 0.203 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.269338e-01 | 0.203 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.269338e-01 | 0.203 |
| R-HSA-72172 | mRNA Splicing | 6.304015e-01 | 0.200 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.323157e-01 | 0.199 |
| R-HSA-211976 | Endogenous sterols | 6.323157e-01 | 0.199 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.323157e-01 | 0.199 |
| R-HSA-1268020 | Mitochondrial protein import | 6.376203e-01 | 0.195 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.428486e-01 | 0.192 |
| R-HSA-373755 | Semaphorin interactions | 6.428486e-01 | 0.192 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.480019e-01 | 0.188 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.501853e-01 | 0.187 |
| R-HSA-1234174 | Cellular response to hypoxia | 6.530811e-01 | 0.185 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.538036e-01 | 0.185 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.566535e-01 | 0.183 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.571603e-01 | 0.182 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.571603e-01 | 0.182 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.630216e-01 | 0.178 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.630216e-01 | 0.178 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.640241e-01 | 0.178 |
| R-HSA-9664407 | Parasite infection | 6.640241e-01 | 0.178 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.640241e-01 | 0.178 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.674145e-01 | 0.176 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.741128e-01 | 0.171 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.774031e-01 | 0.169 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.774031e-01 | 0.169 |
| R-HSA-8951664 | Neddylation | 6.788479e-01 | 0.168 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.807016e-01 | 0.167 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.820598e-01 | 0.166 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.820598e-01 | 0.166 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.820598e-01 | 0.166 |
| R-HSA-189445 | Metabolism of porphyrins | 6.820598e-01 | 0.166 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.866496e-01 | 0.163 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.871817e-01 | 0.163 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.911734e-01 | 0.160 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.911734e-01 | 0.160 |
| R-HSA-69242 | S Phase | 6.935539e-01 | 0.159 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 6.956321e-01 | 0.158 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.956321e-01 | 0.158 |
| R-HSA-8953854 | Metabolism of RNA | 6.982702e-01 | 0.156 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.998191e-01 | 0.155 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.000268e-01 | 0.155 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.000268e-01 | 0.155 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.000268e-01 | 0.155 |
| R-HSA-5689603 | UCH proteinases | 7.043582e-01 | 0.152 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.059782e-01 | 0.151 |
| R-HSA-9609507 | Protein localization | 7.090181e-01 | 0.149 |
| R-HSA-6783783 | Interleukin-10 signaling | 7.128352e-01 | 0.147 |
| R-HSA-5619084 | ABC transporter disorders | 7.128352e-01 | 0.147 |
| R-HSA-191273 | Cholesterol biosynthesis | 7.128352e-01 | 0.147 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.150197e-01 | 0.146 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.169825e-01 | 0.144 |
| R-HSA-162587 | HIV Life Cycle | 7.209175e-01 | 0.142 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.210702e-01 | 0.142 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.210702e-01 | 0.142 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.238278e-01 | 0.140 |
| R-HSA-9711097 | Cellular response to starvation | 7.238278e-01 | 0.140 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.248888e-01 | 0.140 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 7.250990e-01 | 0.140 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.295719e-01 | 0.137 |
| R-HSA-9679506 | SARS-CoV Infections | 7.304905e-01 | 0.136 |
| R-HSA-109582 | Hemostasis | 7.319507e-01 | 0.136 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.327486e-01 | 0.135 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 7.480839e-01 | 0.126 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 7.488862e-01 | 0.126 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.517242e-01 | 0.124 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.517242e-01 | 0.124 |
| R-HSA-156902 | Peptide chain elongation | 7.553121e-01 | 0.122 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.593844e-01 | 0.120 |
| R-HSA-202424 | Downstream TCR signaling | 7.623336e-01 | 0.118 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.623336e-01 | 0.118 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.657688e-01 | 0.116 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.691546e-01 | 0.114 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.691546e-01 | 0.114 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.699645e-01 | 0.114 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.724916e-01 | 0.112 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.724916e-01 | 0.112 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.724916e-01 | 0.112 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.757806e-01 | 0.110 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.780536e-01 | 0.109 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.790222e-01 | 0.108 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.822172e-01 | 0.107 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.822172e-01 | 0.107 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.826981e-01 | 0.106 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.853662e-01 | 0.105 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.853662e-01 | 0.105 |
| R-HSA-1296071 | Potassium Channels | 7.884698e-01 | 0.103 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.915287e-01 | 0.102 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.915287e-01 | 0.102 |
| R-HSA-422356 | Regulation of insulin secretion | 7.945436e-01 | 0.100 |
| R-HSA-190236 | Signaling by FGFR | 7.945436e-01 | 0.100 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.975151e-01 | 0.098 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.020569e-01 | 0.096 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.033303e-01 | 0.095 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.061752e-01 | 0.094 |
| R-HSA-192823 | Viral mRNA Translation | 8.089792e-01 | 0.092 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.117427e-01 | 0.091 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.140291e-01 | 0.089 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 8.144665e-01 | 0.089 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.224045e-01 | 0.085 |
| R-HSA-69239 | Synthesis of DNA | 8.224045e-01 | 0.085 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.300043e-01 | 0.081 |
| R-HSA-202403 | TCR signaling | 8.300043e-01 | 0.081 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.323633e-01 | 0.080 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.323633e-01 | 0.080 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.348900e-01 | 0.078 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.348900e-01 | 0.078 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.348900e-01 | 0.078 |
| R-HSA-909733 | Interferon alpha/beta signaling | 8.465013e-01 | 0.072 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.465013e-01 | 0.072 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.509148e-01 | 0.070 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.509148e-01 | 0.070 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.552020e-01 | 0.068 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.634114e-01 | 0.064 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.653903e-01 | 0.063 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.779854e-01 | 0.057 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.784658e-01 | 0.056 |
| R-HSA-72312 | rRNA processing | 8.807632e-01 | 0.055 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 8.819637e-01 | 0.055 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.836748e-01 | 0.054 |
| R-HSA-15869 | Metabolism of nucleotides | 8.861448e-01 | 0.052 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.900330e-01 | 0.051 |
| R-HSA-72766 | Translation | 8.922948e-01 | 0.049 |
| R-HSA-6807070 | PTEN Regulation | 8.965042e-01 | 0.047 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.965042e-01 | 0.047 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.998092e-01 | 0.046 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 9.037965e-01 | 0.044 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.037965e-01 | 0.044 |
| R-HSA-9758941 | Gastrulation | 9.118750e-01 | 0.040 |
| R-HSA-2142753 | Arachidonate metabolism | 9.156572e-01 | 0.038 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.180885e-01 | 0.037 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.216051e-01 | 0.035 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.230168e-01 | 0.035 |
| R-HSA-877300 | Interferon gamma signaling | 9.238656e-01 | 0.034 |
| R-HSA-556833 | Metabolism of lipids | 9.281442e-01 | 0.032 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.292369e-01 | 0.032 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.305488e-01 | 0.031 |
| R-HSA-5619102 | SLC transporter disorders | 9.322767e-01 | 0.030 |
| R-HSA-418555 | G alpha (s) signalling events | 9.370569e-01 | 0.028 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.388736e-01 | 0.027 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.388736e-01 | 0.027 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.433903e-01 | 0.025 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.537277e-01 | 0.021 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.558385e-01 | 0.020 |
| R-HSA-211859 | Biological oxidations | 9.563302e-01 | 0.019 |
| R-HSA-428157 | Sphingolipid metabolism | 9.594493e-01 | 0.018 |
| R-HSA-6805567 | Keratinization | 9.628666e-01 | 0.016 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.681879e-01 | 0.014 |
| R-HSA-388396 | GPCR downstream signalling | 9.750159e-01 | 0.011 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.758300e-01 | 0.011 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.794540e-01 | 0.009 |
| R-HSA-8978868 | Fatty acid metabolism | 9.861621e-01 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 9.887101e-01 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 9.941124e-01 | 0.003 |
| R-HSA-913531 | Interferon Signaling | 9.973153e-01 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.975803e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.977198e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.998312e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.998763e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.894 | 0.169 | 2 | 0.884 |
NLK |
0.891 | 0.241 | 1 | 0.896 |
ULK2 |
0.886 | 0.066 | 2 | 0.854 |
PKCD |
0.883 | 0.218 | 2 | 0.894 |
TGFBR2 |
0.882 | 0.107 | -2 | 0.832 |
PKN3 |
0.882 | 0.129 | -3 | 0.827 |
DSTYK |
0.882 | 0.112 | 2 | 0.914 |
CDC7 |
0.881 | 0.009 | 1 | 0.875 |
PRPK |
0.881 | -0.116 | -1 | 0.867 |
GCN2 |
0.881 | -0.025 | 2 | 0.860 |
PIM3 |
0.881 | 0.079 | -3 | 0.815 |
MST4 |
0.880 | 0.168 | 2 | 0.917 |
NEK6 |
0.880 | 0.100 | -2 | 0.875 |
NUAK2 |
0.880 | 0.122 | -3 | 0.830 |
ERK5 |
0.879 | 0.141 | 1 | 0.839 |
WNK1 |
0.879 | 0.142 | -2 | 0.840 |
CAMK1B |
0.878 | 0.020 | -3 | 0.847 |
NIK |
0.878 | 0.129 | -3 | 0.873 |
RSK2 |
0.878 | 0.113 | -3 | 0.756 |
NEK7 |
0.878 | 0.026 | -3 | 0.831 |
CDKL1 |
0.877 | 0.056 | -3 | 0.776 |
PKN2 |
0.877 | 0.147 | -3 | 0.829 |
BMPR2 |
0.877 | -0.076 | -2 | 0.892 |
RAF1 |
0.877 | -0.067 | 1 | 0.880 |
CDKL5 |
0.876 | 0.086 | -3 | 0.772 |
CLK3 |
0.876 | 0.162 | 1 | 0.882 |
MOS |
0.876 | -0.012 | 1 | 0.889 |
NEK9 |
0.876 | 0.107 | 2 | 0.912 |
MLK1 |
0.876 | 0.090 | 2 | 0.907 |
AMPKA1 |
0.875 | 0.096 | -3 | 0.851 |
RIPK3 |
0.875 | 0.038 | 3 | 0.754 |
ATR |
0.875 | 0.054 | 1 | 0.908 |
MARK4 |
0.875 | 0.074 | 4 | 0.833 |
TBK1 |
0.874 | -0.076 | 1 | 0.779 |
MTOR |
0.874 | -0.082 | 1 | 0.849 |
NDR1 |
0.874 | 0.060 | -3 | 0.828 |
P90RSK |
0.874 | 0.062 | -3 | 0.758 |
PDHK4 |
0.873 | -0.261 | 1 | 0.895 |
CAMLCK |
0.873 | 0.040 | -2 | 0.848 |
NDR2 |
0.873 | 0.028 | -3 | 0.832 |
MAPKAPK3 |
0.873 | 0.054 | -3 | 0.778 |
PRKD2 |
0.873 | 0.090 | -3 | 0.777 |
ULK1 |
0.872 | -0.052 | -3 | 0.836 |
WNK3 |
0.872 | -0.035 | 1 | 0.862 |
PDHK1 |
0.872 | -0.168 | 1 | 0.878 |
CAMK2G |
0.872 | -0.058 | 2 | 0.801 |
PIM1 |
0.872 | 0.104 | -3 | 0.761 |
RSK3 |
0.871 | 0.062 | -3 | 0.751 |
PKCA |
0.871 | 0.207 | 2 | 0.866 |
DAPK2 |
0.871 | 0.034 | -3 | 0.854 |
PRKD1 |
0.870 | 0.021 | -3 | 0.822 |
TSSK1 |
0.870 | 0.086 | -3 | 0.875 |
PKCB |
0.870 | 0.195 | 2 | 0.869 |
SKMLCK |
0.870 | 0.037 | -2 | 0.835 |
P70S6KB |
0.870 | 0.064 | -3 | 0.787 |
IKKB |
0.869 | -0.129 | -2 | 0.761 |
HUNK |
0.869 | -0.046 | 2 | 0.801 |
IKKE |
0.869 | -0.104 | 1 | 0.771 |
AMPKA2 |
0.869 | 0.076 | -3 | 0.822 |
PKR |
0.869 | 0.192 | 1 | 0.876 |
LATS2 |
0.869 | 0.036 | -5 | 0.811 |
MELK |
0.869 | 0.083 | -3 | 0.812 |
NEK2 |
0.868 | 0.133 | 2 | 0.913 |
MLK2 |
0.868 | 0.026 | 2 | 0.896 |
PKCG |
0.868 | 0.169 | 2 | 0.856 |
TSSK2 |
0.868 | 0.050 | -5 | 0.842 |
MLK3 |
0.868 | 0.140 | 2 | 0.866 |
SRPK1 |
0.868 | 0.083 | -3 | 0.717 |
IRE1 |
0.868 | 0.054 | 1 | 0.829 |
ANKRD3 |
0.868 | 0.028 | 1 | 0.906 |
NIM1 |
0.868 | 0.011 | 3 | 0.796 |
IRE2 |
0.867 | 0.092 | 2 | 0.856 |
ICK |
0.867 | 0.028 | -3 | 0.816 |
MNK2 |
0.867 | 0.093 | -2 | 0.789 |
CHAK2 |
0.867 | -0.017 | -1 | 0.841 |
NUAK1 |
0.867 | 0.057 | -3 | 0.795 |
PLK1 |
0.866 | 0.092 | -2 | 0.860 |
CAMK2D |
0.866 | -0.018 | -3 | 0.841 |
HIPK4 |
0.866 | 0.040 | 1 | 0.855 |
QIK |
0.866 | 0.055 | -3 | 0.826 |
PHKG1 |
0.866 | 0.104 | -3 | 0.820 |
PKACG |
0.866 | 0.053 | -2 | 0.760 |
CAMK4 |
0.866 | 0.011 | -3 | 0.818 |
AURC |
0.866 | 0.102 | -2 | 0.669 |
PKCH |
0.865 | 0.148 | 2 | 0.853 |
GRK5 |
0.864 | -0.146 | -3 | 0.820 |
LATS1 |
0.863 | 0.096 | -3 | 0.846 |
RIPK1 |
0.863 | -0.094 | 1 | 0.869 |
AURB |
0.863 | 0.084 | -2 | 0.671 |
PRKD3 |
0.863 | 0.045 | -3 | 0.731 |
PKG2 |
0.863 | 0.106 | -2 | 0.697 |
PAK3 |
0.862 | 0.011 | -2 | 0.775 |
QSK |
0.862 | 0.065 | 4 | 0.818 |
SRPK2 |
0.862 | 0.075 | -3 | 0.646 |
CLK1 |
0.862 | 0.133 | -3 | 0.733 |
PKCZ |
0.862 | 0.110 | 2 | 0.892 |
CDK8 |
0.861 | 0.071 | 1 | 0.745 |
DLK |
0.861 | -0.114 | 1 | 0.890 |
MNK1 |
0.861 | 0.101 | -2 | 0.806 |
GRK6 |
0.861 | -0.024 | 1 | 0.881 |
SGK3 |
0.861 | 0.111 | -3 | 0.748 |
MAPKAPK2 |
0.860 | 0.033 | -3 | 0.725 |
MLK4 |
0.860 | 0.087 | 2 | 0.846 |
CDK5 |
0.860 | 0.143 | 1 | 0.761 |
ALK4 |
0.860 | 0.011 | -2 | 0.829 |
BCKDK |
0.860 | -0.170 | -1 | 0.796 |
PAK1 |
0.860 | 0.024 | -2 | 0.771 |
ATM |
0.860 | 0.057 | 1 | 0.861 |
CDK7 |
0.860 | 0.082 | 1 | 0.746 |
MASTL |
0.859 | -0.279 | -2 | 0.813 |
CLK4 |
0.859 | 0.095 | -3 | 0.746 |
PIM2 |
0.859 | 0.107 | -3 | 0.734 |
RSK4 |
0.859 | 0.084 | -3 | 0.728 |
PERK |
0.859 | 0.063 | -2 | 0.868 |
TTBK2 |
0.859 | -0.110 | 2 | 0.751 |
MARK2 |
0.859 | 0.067 | 4 | 0.757 |
SIK |
0.859 | 0.045 | -3 | 0.755 |
PAK6 |
0.858 | 0.074 | -2 | 0.709 |
HRI |
0.858 | 0.029 | -2 | 0.874 |
YSK4 |
0.858 | 0.003 | 1 | 0.815 |
CHAK1 |
0.858 | -0.012 | 2 | 0.846 |
TGFBR1 |
0.858 | 0.031 | -2 | 0.805 |
CAMK2B |
0.858 | 0.033 | 2 | 0.749 |
BRSK2 |
0.857 | 0.012 | -3 | 0.819 |
SRPK3 |
0.857 | 0.047 | -3 | 0.685 |
IKKA |
0.857 | -0.084 | -2 | 0.748 |
PKCT |
0.857 | 0.127 | 2 | 0.860 |
VRK2 |
0.857 | -0.096 | 1 | 0.920 |
IRAK4 |
0.856 | 0.073 | 1 | 0.843 |
BMPR1B |
0.856 | 0.081 | 1 | 0.832 |
MYLK4 |
0.856 | 0.037 | -2 | 0.774 |
MARK3 |
0.856 | 0.061 | 4 | 0.790 |
CDK19 |
0.856 | 0.075 | 1 | 0.707 |
BRSK1 |
0.855 | 0.017 | -3 | 0.787 |
CHK1 |
0.855 | -0.007 | -3 | 0.845 |
P38A |
0.855 | 0.107 | 1 | 0.768 |
KIS |
0.855 | 0.068 | 1 | 0.765 |
CDK2 |
0.855 | 0.114 | 1 | 0.785 |
GRK1 |
0.855 | -0.008 | -2 | 0.789 |
JNK2 |
0.855 | 0.139 | 1 | 0.697 |
SMG1 |
0.855 | 0.060 | 1 | 0.862 |
CDK18 |
0.855 | 0.127 | 1 | 0.672 |
MEK1 |
0.854 | -0.139 | 2 | 0.857 |
ERK7 |
0.854 | 0.282 | 2 | 0.735 |
PHKG2 |
0.854 | 0.099 | -3 | 0.802 |
ACVR2A |
0.854 | 0.044 | -2 | 0.826 |
ERK2 |
0.854 | 0.106 | 1 | 0.741 |
PAK2 |
0.853 | -0.019 | -2 | 0.761 |
MSK2 |
0.853 | -0.034 | -3 | 0.708 |
DNAPK |
0.853 | 0.084 | 1 | 0.802 |
PKCI |
0.853 | 0.149 | 2 | 0.878 |
MARK1 |
0.853 | 0.033 | 4 | 0.805 |
DYRK2 |
0.853 | 0.066 | 1 | 0.776 |
AKT2 |
0.853 | 0.056 | -3 | 0.668 |
PKACB |
0.853 | 0.079 | -2 | 0.694 |
CAMK2A |
0.853 | 0.004 | 2 | 0.773 |
MEKK1 |
0.852 | 0.012 | 1 | 0.866 |
WNK4 |
0.852 | 0.003 | -2 | 0.826 |
ALK2 |
0.852 | 0.032 | -2 | 0.823 |
NEK5 |
0.852 | 0.064 | 1 | 0.875 |
MST3 |
0.851 | 0.157 | 2 | 0.909 |
SNRK |
0.851 | -0.102 | 2 | 0.745 |
CDK14 |
0.851 | 0.148 | 1 | 0.716 |
PLK3 |
0.851 | -0.021 | 2 | 0.751 |
ZAK |
0.851 | 0.000 | 1 | 0.844 |
ERK1 |
0.850 | 0.105 | 1 | 0.692 |
HIPK1 |
0.850 | 0.109 | 1 | 0.787 |
PLK4 |
0.850 | -0.039 | 2 | 0.668 |
CDK1 |
0.850 | 0.110 | 1 | 0.706 |
DRAK1 |
0.850 | 0.014 | 1 | 0.836 |
FAM20C |
0.850 | 0.039 | 2 | 0.581 |
CDK13 |
0.850 | 0.058 | 1 | 0.718 |
AKT1 |
0.850 | 0.092 | -3 | 0.694 |
JNK3 |
0.850 | 0.100 | 1 | 0.728 |
GRK4 |
0.850 | -0.178 | -2 | 0.834 |
CDK17 |
0.849 | 0.110 | 1 | 0.623 |
ACVR2B |
0.849 | 0.013 | -2 | 0.836 |
BRAF |
0.849 | -0.045 | -4 | 0.835 |
MSK1 |
0.849 | 0.004 | -3 | 0.723 |
SMMLCK |
0.848 | 0.025 | -3 | 0.804 |
MEKK2 |
0.848 | -0.009 | 2 | 0.874 |
DCAMKL1 |
0.848 | 0.008 | -3 | 0.785 |
CAMK1G |
0.848 | -0.013 | -3 | 0.755 |
CDK16 |
0.848 | 0.168 | 1 | 0.637 |
MEK5 |
0.848 | -0.142 | 2 | 0.877 |
PKCE |
0.848 | 0.162 | 2 | 0.850 |
SSTK |
0.848 | 0.048 | 4 | 0.798 |
P38B |
0.847 | 0.098 | 1 | 0.698 |
HIPK3 |
0.847 | 0.077 | 1 | 0.790 |
CDK9 |
0.847 | 0.062 | 1 | 0.727 |
PRP4 |
0.847 | 0.067 | -3 | 0.753 |
GRK7 |
0.846 | 0.027 | 1 | 0.809 |
NEK8 |
0.846 | 0.054 | 2 | 0.905 |
CDK10 |
0.846 | 0.170 | 1 | 0.703 |
P38G |
0.846 | 0.112 | 1 | 0.620 |
TLK2 |
0.846 | -0.101 | 1 | 0.858 |
PKN1 |
0.846 | 0.100 | -3 | 0.716 |
AURA |
0.845 | 0.008 | -2 | 0.641 |
TAO2 |
0.845 | 0.080 | 2 | 0.925 |
P70S6K |
0.844 | 0.003 | -3 | 0.696 |
DCAMKL2 |
0.844 | -0.011 | -3 | 0.811 |
PRKX |
0.844 | 0.096 | -3 | 0.666 |
DYRK1A |
0.844 | 0.042 | 1 | 0.812 |
CDK3 |
0.844 | 0.148 | 1 | 0.639 |
CAMKK1 |
0.844 | 0.012 | -2 | 0.803 |
TAO3 |
0.844 | 0.036 | 1 | 0.846 |
MEKK3 |
0.844 | -0.129 | 1 | 0.858 |
MAPKAPK5 |
0.844 | -0.111 | -3 | 0.707 |
CDK12 |
0.843 | 0.059 | 1 | 0.696 |
NEK4 |
0.843 | 0.057 | 1 | 0.836 |
HIPK2 |
0.842 | 0.091 | 1 | 0.687 |
PKACA |
0.842 | 0.057 | -2 | 0.648 |
PINK1 |
0.841 | -0.144 | 1 | 0.856 |
CLK2 |
0.841 | 0.105 | -3 | 0.731 |
EEF2K |
0.841 | 0.113 | 3 | 0.834 |
CAMK1D |
0.841 | 0.014 | -3 | 0.679 |
BMPR1A |
0.841 | 0.042 | 1 | 0.813 |
TLK1 |
0.840 | -0.101 | -2 | 0.842 |
IRAK1 |
0.840 | -0.161 | -1 | 0.802 |
LOK |
0.839 | 0.103 | -2 | 0.788 |
CAMKK2 |
0.839 | -0.013 | -2 | 0.795 |
CDK6 |
0.839 | 0.144 | 1 | 0.695 |
NEK1 |
0.838 | 0.096 | 1 | 0.846 |
HGK |
0.838 | 0.059 | 3 | 0.845 |
DYRK3 |
0.838 | 0.064 | 1 | 0.794 |
CDK4 |
0.838 | 0.129 | 1 | 0.680 |
PAK5 |
0.837 | 0.005 | -2 | 0.648 |
DYRK1B |
0.837 | 0.067 | 1 | 0.725 |
NEK11 |
0.837 | -0.107 | 1 | 0.850 |
LKB1 |
0.837 | -0.023 | -3 | 0.846 |
MPSK1 |
0.837 | -0.039 | 1 | 0.793 |
TTBK1 |
0.837 | -0.123 | 2 | 0.658 |
MRCKB |
0.836 | 0.089 | -3 | 0.729 |
TNIK |
0.836 | 0.087 | 3 | 0.849 |
MEKK6 |
0.836 | -0.005 | 1 | 0.845 |
ROCK2 |
0.836 | 0.119 | -3 | 0.777 |
DAPK3 |
0.836 | 0.037 | -3 | 0.784 |
GRK2 |
0.835 | -0.104 | -2 | 0.716 |
MINK |
0.835 | 0.030 | 1 | 0.833 |
MRCKA |
0.835 | 0.086 | -3 | 0.748 |
AKT3 |
0.834 | 0.065 | -3 | 0.600 |
MST2 |
0.834 | -0.011 | 1 | 0.852 |
P38D |
0.834 | 0.105 | 1 | 0.640 |
CHK2 |
0.834 | 0.018 | -3 | 0.619 |
GAK |
0.834 | -0.035 | 1 | 0.848 |
GCK |
0.834 | 0.027 | 1 | 0.845 |
YSK1 |
0.834 | 0.109 | 2 | 0.910 |
LRRK2 |
0.834 | -0.003 | 2 | 0.916 |
GSK3B |
0.833 | -0.026 | 4 | 0.413 |
MAP3K15 |
0.833 | -0.039 | 1 | 0.825 |
TAK1 |
0.832 | 0.000 | 1 | 0.872 |
CAMK1A |
0.832 | 0.022 | -3 | 0.642 |
SGK1 |
0.832 | 0.054 | -3 | 0.583 |
BUB1 |
0.832 | 0.100 | -5 | 0.787 |
PDK1 |
0.831 | -0.097 | 1 | 0.850 |
VRK1 |
0.831 | -0.039 | 2 | 0.858 |
PAK4 |
0.831 | -0.005 | -2 | 0.651 |
MOK |
0.831 | 0.105 | 1 | 0.786 |
NEK3 |
0.830 | -0.000 | 1 | 0.817 |
HPK1 |
0.830 | 0.037 | 1 | 0.828 |
DYRK4 |
0.830 | 0.050 | 1 | 0.701 |
GSK3A |
0.830 | 0.007 | 4 | 0.423 |
KHS2 |
0.829 | 0.107 | 1 | 0.834 |
MST1 |
0.829 | -0.001 | 1 | 0.833 |
KHS1 |
0.829 | 0.060 | 1 | 0.819 |
PASK |
0.828 | -0.095 | -3 | 0.821 |
SLK |
0.827 | 0.007 | -2 | 0.729 |
RIPK2 |
0.827 | -0.162 | 1 | 0.800 |
DAPK1 |
0.827 | 0.007 | -3 | 0.757 |
DMPK1 |
0.827 | 0.109 | -3 | 0.750 |
TTK |
0.826 | 0.119 | -2 | 0.862 |
MEK2 |
0.826 | -0.164 | 2 | 0.849 |
ROCK1 |
0.826 | 0.103 | -3 | 0.746 |
MAK |
0.825 | 0.075 | -2 | 0.688 |
PKG1 |
0.824 | 0.024 | -2 | 0.619 |
CK1E |
0.821 | -0.128 | -3 | 0.450 |
STK33 |
0.820 | -0.147 | 2 | 0.649 |
JNK1 |
0.820 | 0.043 | 1 | 0.677 |
MYO3B |
0.820 | 0.095 | 2 | 0.923 |
PBK |
0.819 | -0.046 | 1 | 0.758 |
CK2A2 |
0.819 | 0.051 | 1 | 0.714 |
SBK |
0.819 | -0.005 | -3 | 0.558 |
PLK2 |
0.818 | -0.055 | -3 | 0.752 |
OSR1 |
0.817 | -0.002 | 2 | 0.872 |
TAO1 |
0.817 | 0.036 | 1 | 0.779 |
GRK3 |
0.816 | -0.120 | -2 | 0.671 |
MYO3A |
0.815 | 0.039 | 1 | 0.827 |
CRIK |
0.814 | 0.017 | -3 | 0.691 |
BIKE |
0.814 | 0.004 | 1 | 0.706 |
CK1D |
0.814 | -0.128 | -3 | 0.399 |
HASPIN |
0.813 | 0.010 | -1 | 0.704 |
CK1G1 |
0.812 | -0.159 | -3 | 0.441 |
CK1A2 |
0.810 | -0.139 | -3 | 0.397 |
PDHK3_TYR |
0.809 | 0.211 | 4 | 0.846 |
ASK1 |
0.809 | -0.106 | 1 | 0.810 |
CK2A1 |
0.808 | 0.026 | 1 | 0.694 |
TESK1_TYR |
0.802 | 0.037 | 3 | 0.880 |
LIMK2_TYR |
0.800 | 0.090 | -3 | 0.899 |
STLK3 |
0.798 | -0.145 | 1 | 0.808 |
PKMYT1_TYR |
0.798 | -0.040 | 3 | 0.849 |
AAK1 |
0.796 | 0.026 | 1 | 0.592 |
PDHK4_TYR |
0.796 | -0.003 | 2 | 0.876 |
MAP2K7_TYR |
0.796 | -0.162 | 2 | 0.877 |
MAP2K4_TYR |
0.795 | -0.124 | -1 | 0.889 |
ALPHAK3 |
0.794 | -0.144 | -1 | 0.781 |
PINK1_TYR |
0.794 | -0.092 | 1 | 0.877 |
LIMK1_TYR |
0.793 | -0.057 | 2 | 0.904 |
RET |
0.793 | -0.022 | 1 | 0.855 |
TYRO3 |
0.793 | 0.009 | 3 | 0.797 |
TYK2 |
0.792 | -0.041 | 1 | 0.848 |
ROS1 |
0.792 | -0.004 | 3 | 0.775 |
MAP2K6_TYR |
0.792 | -0.133 | -1 | 0.878 |
TNNI3K_TYR |
0.791 | 0.135 | 1 | 0.869 |
EPHA6 |
0.790 | 0.021 | -1 | 0.857 |
BMPR2_TYR |
0.789 | -0.104 | -1 | 0.844 |
MST1R |
0.789 | -0.070 | 3 | 0.802 |
PDHK1_TYR |
0.788 | -0.167 | -1 | 0.890 |
JAK2 |
0.787 | -0.081 | 1 | 0.852 |
EPHB4 |
0.786 | -0.012 | -1 | 0.859 |
TXK |
0.786 | 0.108 | 1 | 0.869 |
TNK2 |
0.785 | 0.025 | 3 | 0.756 |
CSF1R |
0.785 | -0.067 | 3 | 0.783 |
ABL2 |
0.784 | -0.005 | -1 | 0.864 |
JAK1 |
0.784 | 0.046 | 1 | 0.802 |
PDGFRB |
0.784 | -0.033 | 3 | 0.804 |
YES1 |
0.783 | -0.011 | -1 | 0.901 |
TNK1 |
0.783 | -0.013 | 3 | 0.777 |
YANK3 |
0.783 | -0.156 | 2 | 0.394 |
DDR1 |
0.782 | -0.147 | 4 | 0.755 |
TEC |
0.782 | 0.085 | -1 | 0.835 |
NEK10_TYR |
0.781 | -0.044 | 1 | 0.716 |
JAK3 |
0.781 | -0.097 | 1 | 0.843 |
ITK |
0.781 | -0.002 | -1 | 0.849 |
ABL1 |
0.781 | -0.023 | -1 | 0.869 |
FGR |
0.780 | -0.098 | 1 | 0.872 |
AXL |
0.780 | -0.020 | 3 | 0.767 |
HCK |
0.779 | -0.057 | -1 | 0.868 |
LCK |
0.777 | -0.019 | -1 | 0.855 |
PDGFRA |
0.777 | -0.101 | 3 | 0.800 |
FER |
0.777 | -0.155 | 1 | 0.896 |
FLT3 |
0.777 | -0.096 | 3 | 0.789 |
TEK |
0.777 | -0.097 | 3 | 0.734 |
KDR |
0.776 | -0.060 | 3 | 0.753 |
INSRR |
0.776 | -0.110 | 3 | 0.747 |
SRMS |
0.776 | -0.069 | 1 | 0.884 |
MERTK |
0.775 | -0.036 | 3 | 0.764 |
ALK |
0.775 | -0.049 | 3 | 0.724 |
EPHB1 |
0.775 | -0.074 | 1 | 0.889 |
BTK |
0.775 | -0.070 | -1 | 0.834 |
FGFR1 |
0.775 | -0.118 | 3 | 0.765 |
FGFR2 |
0.775 | -0.139 | 3 | 0.783 |
BLK |
0.774 | 0.006 | -1 | 0.870 |
EPHB3 |
0.773 | -0.079 | -1 | 0.847 |
WEE1_TYR |
0.773 | -0.047 | -1 | 0.763 |
LTK |
0.773 | -0.062 | 3 | 0.742 |
PTK6 |
0.771 | -0.126 | -1 | 0.793 |
KIT |
0.771 | -0.162 | 3 | 0.783 |
EPHB2 |
0.771 | -0.078 | -1 | 0.843 |
EPHA4 |
0.770 | -0.120 | 2 | 0.735 |
EPHA1 |
0.770 | -0.051 | 3 | 0.749 |
BMX |
0.770 | -0.052 | -1 | 0.763 |
DDR2 |
0.767 | -0.028 | 3 | 0.735 |
PTK2B |
0.767 | 0.007 | -1 | 0.864 |
FRK |
0.766 | -0.082 | -1 | 0.885 |
MET |
0.765 | -0.154 | 3 | 0.775 |
NTRK2 |
0.765 | -0.164 | 3 | 0.750 |
EPHA7 |
0.765 | -0.085 | 2 | 0.763 |
CK1A |
0.765 | -0.175 | -3 | 0.303 |
NTRK1 |
0.764 | -0.200 | -1 | 0.830 |
FLT4 |
0.763 | -0.163 | 3 | 0.744 |
INSR |
0.762 | -0.165 | 3 | 0.724 |
LYN |
0.761 | -0.106 | 3 | 0.718 |
FLT1 |
0.761 | -0.157 | -1 | 0.820 |
FYN |
0.760 | -0.083 | -1 | 0.822 |
EPHA3 |
0.760 | -0.169 | 2 | 0.727 |
FGFR3 |
0.760 | -0.192 | 3 | 0.757 |
ERBB2 |
0.759 | -0.223 | 1 | 0.805 |
NTRK3 |
0.756 | -0.190 | -1 | 0.773 |
CK1G3 |
0.755 | -0.163 | -3 | 0.253 |
MATK |
0.754 | -0.168 | -1 | 0.771 |
EPHA5 |
0.754 | -0.131 | 2 | 0.727 |
SRC |
0.752 | -0.123 | -1 | 0.849 |
MUSK |
0.752 | -0.127 | 1 | 0.694 |
YANK2 |
0.751 | -0.183 | 2 | 0.414 |
EPHA8 |
0.750 | -0.154 | -1 | 0.810 |
EGFR |
0.749 | -0.151 | 1 | 0.719 |
CSK |
0.748 | -0.226 | 2 | 0.764 |
FGFR4 |
0.743 | -0.201 | -1 | 0.795 |
IGF1R |
0.740 | -0.212 | 3 | 0.666 |
PTK2 |
0.740 | -0.114 | -1 | 0.749 |
EPHA2 |
0.737 | -0.182 | -1 | 0.767 |
SYK |
0.736 | -0.144 | -1 | 0.737 |
FES |
0.733 | -0.161 | -1 | 0.750 |
ERBB4 |
0.732 | -0.164 | 1 | 0.730 |
CK1G2 |
0.721 | -0.209 | -3 | 0.355 |
ZAP70 |
0.710 | -0.183 | -1 | 0.655 |