Motif 957 (n=85)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E7EW31 | PROB1 | S277 | ochoa | Proline-rich basic protein 1 | None |
| O00257 | CBX4 | S90 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O00311 | CDC7 | S27 | ochoa | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O00418 | EEF2K | Y468 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O15126 | SCAMP1 | S43 | ochoa | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O43310 | CTIF | S245 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
| O43752 | STX6 | S86 | ochoa | Syntaxin-6 | SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}. |
| O60921 | HUS1 | S217 | ochoa | Checkpoint protein HUS1 (hHUS1) | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:21659603). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). {ECO:0000269|PubMed:21659603}. |
| O96017 | CHEK2 | S456 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P05129 | PRKCG | S664 | ochoa | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P09874 | PARP1 | S383 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P11836 | MS4A1 | S25 | ochoa | B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}. |
| P17152 | TMEM11 | S144 | ochoa | Transmembrane protein 11, mitochondrial (Protein PM1) (Protein PMI) | Plays a role in mitochondrial morphogenesis. {ECO:0000269|PubMed:21274005}. |
| P17174 | GOT1 | S149 | ochoa | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| P28715 | ERCC5 | S697 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29401 | TKT | S439 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P29966 | MARCKS | S52 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P30414 | NKTR | S1244 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P35558 | PCK1 | S90 | psp | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-) | Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:24863970, PubMed:26971250, PubMed:28216384, PubMed:30193097). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:24863970, PubMed:26971250, PubMed:28216384, PubMed:30193097). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (By similarity). The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (PubMed:32322062). The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (PubMed:32322062). {ECO:0000250|UniProtKB:Q9Z2V4, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26971250, ECO:0000269|PubMed:28216384, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:32322062}. |
| P40121 | CAPG | S129 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P45974 | USP5 | S783 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46379 | BAG6 | S26 | psp | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P49588 | AARS1 | S555 | ochoa | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| P49790 | NUP153 | S1047 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1819 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52732 | KIF11 | S39 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P68431 | H3C1 | S29 | ochoa | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P78527 | PRKDC | S2685 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78559 | MAP1A | S1264 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P84243 | H3-3A | S29 | ochoa | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q01082 | SPTBN1 | S2138 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02218 | OGDH | S871 | ochoa | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (PubMed:24495017, PubMed:25210035, PubMed:28435050). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (PubMed:24495017, PubMed:25210035, PubMed:28435050, PubMed:35272141). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids (PubMed:25210035). Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (PubMed:28435050). Mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). {ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:25210035, ECO:0000269|PubMed:28435050, ECO:0000269|PubMed:29211711, ECO:0000303|PubMed:25210035}. |
| Q02952 | AKAP12 | S1618 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | S926 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q04759 | PRKCQ | S685 | ochoa | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| Q12824 | SMARCB1 | S129 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5) | Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. {ECO:0000250|UniProtKB:Q9Z0H3, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:12226744, ECO:0000269|PubMed:14604992, ECO:0000269|PubMed:16267391, ECO:0000269|PubMed:16314535, ECO:0000269|PubMed:9448295}. |
| Q12888 | TP53BP1 | S233 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13393 | PLD1 | S519 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q14684 | RRP1B | S679 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q15047 | SETDB1 | S1025 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15717 | ELAVL1 | S304 | psp | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q16695 | H3-4 | S29 | ochoa | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5T1M5 | FKBP15 | S344 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5TEC6 | H3-7 | S29 | ochoa | Histone H3-7 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P68431}. |
| Q5VUA4 | ZNF318 | S1869 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q68EM7 | ARHGAP17 | S859 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6NZI2 | CAVIN1 | S36 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q71DI3 | H3C15 | S29 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7Z2Z1 | TICRR | S1763 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q8IXU6 | SLC35F2 | S24 | ochoa | Solute carrier family 35 member F2 | Putative solute transporter. {ECO:0000305}. |
| Q8NC44 | RETREG2 | S281 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8ND30 | PPFIBP2 | S454 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8TAQ2 | SMARCC2 | S806 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8WYP5 | AHCTF1 | S1250 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q93009 | USP7 | S967 | ochoa | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}. |
| Q96C34 | RUNDC1 | S497 | ochoa | RUN domain-containing protein 1 | May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}. |
| Q96PK6 | RBM14 | S560 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q99490 | AGAP2 | S750 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q9BQG0 | MYBBP1A | S1203 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BST9 | RTKN | S448 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9GZY8 | MFF | S223 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H089 | LSG1 | S629 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H582 | ZNF644 | S1140 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H814 | PHAX | S102 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9HCM4 | EPB41L5 | S39 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NX61 | TMEM161A | S69 | ochoa | Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) | May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}. |
| Q9NZN5 | ARHGEF12 | S751 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P107 | GMIP | S885 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P2D1 | CHD7 | S2490 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UHB7 | AFF4 | S555 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UMS6 | SYNPO2 | S691 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMZ2 | SYNRG | S1098 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UN79 | SOX13 | S98 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9Y2X7 | GIT1 | S536 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y446 | PKP3 | S280 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y520 | PRRC2C | S1100 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| R4GMW8 | BIVM-ERCC5 | S1151 | ochoa | DNA excision repair protein ERCC-5 | None |
| P14314 | PRKCSH | S478 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| Q13283 | G3BP1 | S67 | Sugiyama | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q96GA3 | LTV1 | S34 | Sugiyama | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q13765 | NACA | S191 | Sugiyama | Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}. |
| P11142 | HSPA8 | S381 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P04406 | GAPDH | S25 | Sugiyama | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P18077 | RPL35A | S90 | Sugiyama | Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (Cell growth-inhibiting gene 33 protein) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Required for the proliferation and viability of hematopoietic cells (PubMed:18535205). {ECO:0000269|PubMed:18535205, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P26599 | PTBP1 | S131 | Sugiyama | Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:21518806}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.000006 | 5.200 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000015 | 4.825 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.000054 | 4.268 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.000057 | 4.241 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.000107 | 3.972 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.000115 | 3.939 |
| R-HSA-68875 | Mitotic Prophase | 0.000145 | 3.840 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000143 | 3.845 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.000194 | 3.711 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.000263 | 3.580 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.000303 | 3.518 |
| R-HSA-1640170 | Cell Cycle | 0.000323 | 3.490 |
| R-HSA-912446 | Meiotic recombination | 0.000423 | 3.374 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.000479 | 3.320 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.000526 | 3.279 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.000559 | 3.253 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.000642 | 3.193 |
| R-HSA-211000 | Gene Silencing by RNA | 0.000701 | 3.154 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.000798 | 3.098 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.000928 | 3.032 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.001004 | 2.998 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.000979 | 3.009 |
| R-HSA-5334118 | DNA methylation | 0.001187 | 2.925 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.001187 | 2.926 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.001243 | 2.905 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.001263 | 2.898 |
| R-HSA-168255 | Influenza Infection | 0.001118 | 2.951 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.001424 | 2.846 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.001623 | 2.790 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.001615 | 2.792 |
| R-HSA-69481 | G2/M Checkpoints | 0.001528 | 2.816 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.001693 | 2.771 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.001615 | 2.792 |
| R-HSA-73894 | DNA Repair | 0.001769 | 2.752 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.002129 | 2.672 |
| R-HSA-1500620 | Meiosis | 0.002245 | 2.649 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.002159 | 2.666 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.001924 | 2.716 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.002272 | 2.644 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.002297 | 2.639 |
| R-HSA-68886 | M Phase | 0.002540 | 2.595 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.002734 | 2.563 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.002900 | 2.538 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.002900 | 2.538 |
| R-HSA-9710421 | Defective pyroptosis | 0.003435 | 2.464 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.003583 | 2.446 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.003847 | 2.415 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.004454 | 2.351 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.004480 | 2.349 |
| R-HSA-212436 | Generic Transcription Pathway | 0.004094 | 2.388 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.005101 | 2.292 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.005662 | 2.247 |
| R-HSA-4839726 | Chromatin organization | 0.005064 | 2.295 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.005387 | 2.269 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.005686 | 2.245 |
| R-HSA-422475 | Axon guidance | 0.005923 | 2.227 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.007285 | 2.138 |
| R-HSA-191859 | snRNP Assembly | 0.007285 | 2.138 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.007285 | 2.138 |
| R-HSA-1483148 | Synthesis of PG | 0.006865 | 2.163 |
| R-HSA-2559583 | Cellular Senescence | 0.006378 | 2.195 |
| R-HSA-2262752 | Cellular responses to stress | 0.007376 | 2.132 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.006781 | 2.169 |
| R-HSA-70326 | Glucose metabolism | 0.007477 | 2.126 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.007584 | 2.120 |
| R-HSA-5693538 | Homology Directed Repair | 0.007674 | 2.115 |
| R-HSA-9675108 | Nervous system development | 0.008792 | 2.056 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.009583 | 2.018 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.009883 | 2.005 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.011360 | 1.945 |
| R-HSA-1474165 | Reproduction | 0.010802 | 1.966 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.010980 | 1.959 |
| R-HSA-195721 | Signaling by WNT | 0.011033 | 1.957 |
| R-HSA-8852135 | Protein ubiquitination | 0.012957 | 1.887 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.013376 | 1.874 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.014406 | 1.841 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.014406 | 1.841 |
| R-HSA-3214842 | HDMs demethylate histones | 0.014406 | 1.841 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.014406 | 1.841 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.015126 | 1.820 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.019067 | 1.720 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.020066 | 1.698 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.020066 | 1.698 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.022128 | 1.655 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.022128 | 1.655 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.023190 | 1.635 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.024273 | 1.615 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.025376 | 1.596 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.021120 | 1.675 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.021671 | 1.664 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.023950 | 1.621 |
| R-HSA-156902 | Peptide chain elongation | 0.019517 | 1.710 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.024539 | 1.610 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.018577 | 1.731 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.024539 | 1.610 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.024539 | 1.610 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.022229 | 1.653 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.023190 | 1.635 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.015583 | 1.807 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.022128 | 1.655 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.024273 | 1.615 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.025155 | 1.599 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.016203 | 1.790 |
| R-HSA-9610379 | HCMV Late Events | 0.019649 | 1.707 |
| R-HSA-69306 | DNA Replication | 0.018228 | 1.739 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.016047 | 1.795 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.022795 | 1.642 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.021120 | 1.675 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.017998 | 1.745 |
| R-HSA-162582 | Signal Transduction | 0.025075 | 1.601 |
| R-HSA-977225 | Amyloid fiber formation | 0.015583 | 1.807 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.019517 | 1.710 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.029989 | 1.523 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.031190 | 1.506 |
| R-HSA-192823 | Viral mRNA Translation | 0.029535 | 1.530 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.032910 | 1.483 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.036479 | 1.438 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.031190 | 1.506 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.036479 | 1.438 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.031190 | 1.506 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.030862 | 1.511 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.030862 | 1.511 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.031537 | 1.501 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.033609 | 1.474 |
| R-HSA-9609690 | HCMV Early Events | 0.037640 | 1.424 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.027643 | 1.558 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.038785 | 1.411 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.028883 | 1.539 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.033609 | 1.474 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.028239 | 1.549 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.031190 | 1.506 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.031190 | 1.506 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.032410 | 1.489 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.030195 | 1.520 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.037959 | 1.421 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.028806 | 1.541 |
| R-HSA-8953854 | Metabolism of RNA | 0.027850 | 1.555 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.038785 | 1.411 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.029989 | 1.523 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.026500 | 1.577 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.033480 | 1.475 |
| R-HSA-70171 | Glycolysis | 0.027603 | 1.559 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.026010 | 1.585 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.027325 | 1.563 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.029989 | 1.523 |
| R-HSA-1266738 | Developmental Biology | 0.034942 | 1.457 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.037215 | 1.429 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.029989 | 1.523 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.033649 | 1.473 |
| R-HSA-373752 | Netrin-1 signaling | 0.037475 | 1.426 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.026444 | 1.578 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.026444 | 1.578 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.037640 | 1.424 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.039827 | 1.400 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.040113 | 1.397 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.041012 | 1.387 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.041012 | 1.387 |
| R-HSA-70263 | Gluconeogenesis | 0.042820 | 1.368 |
| R-HSA-3371556 | Cellular response to heat stress | 0.044998 | 1.347 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.046645 | 1.331 |
| R-HSA-1500931 | Cell-Cell communication | 0.047372 | 1.324 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.049170 | 1.308 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.049170 | 1.308 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.049170 | 1.308 |
| R-HSA-418990 | Adherens junctions interactions | 0.051189 | 1.291 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.052805 | 1.277 |
| R-HSA-418597 | G alpha (z) signalling events | 0.052805 | 1.277 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.055797 | 1.253 |
| R-HSA-1483166 | Synthesis of PA | 0.055797 | 1.253 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.056720 | 1.246 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.056720 | 1.246 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.056720 | 1.246 |
| R-HSA-447041 | CHL1 interactions | 0.056720 | 1.246 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.057315 | 1.242 |
| R-HSA-72312 | rRNA processing | 0.060586 | 1.218 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.060864 | 1.216 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.061953 | 1.208 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.062769 | 1.202 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.063527 | 1.197 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.067676 | 1.170 |
| R-HSA-9613354 | Lipophagy | 0.067676 | 1.170 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.083875 | 1.076 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.083875 | 1.076 |
| R-HSA-9853506 | OGDH complex synthesizes succinyl-CoA from 2-OG | 0.094519 | 1.024 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.094519 | 1.024 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.104900 | 0.979 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.104900 | 0.979 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.097577 | 1.011 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.099795 | 1.001 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.115441 | 0.938 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.081686 | 1.088 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.085143 | 1.070 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.098266 | 1.008 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.125722 | 0.901 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.101220 | 0.995 |
| R-HSA-3928664 | Ephrin signaling | 0.125722 | 0.901 |
| R-HSA-192814 | vRNA Synthesis | 0.078506 | 1.105 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.083875 | 1.076 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.125722 | 0.901 |
| R-HSA-68877 | Mitotic Prometaphase | 0.127622 | 0.894 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.094519 | 1.024 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.079975 | 1.097 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.067676 | 1.170 |
| R-HSA-6783984 | Glycine degradation | 0.115441 | 0.938 |
| R-HSA-9609646 | HCMV Infection | 0.073924 | 1.131 |
| R-HSA-9683686 | Maturation of spike protein | 0.073107 | 1.136 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.089212 | 1.050 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.094519 | 1.024 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.105040 | 0.979 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.110256 | 0.958 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.110256 | 0.958 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.099795 | 1.001 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.099795 | 1.001 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.115441 | 0.938 |
| R-HSA-9711097 | Cellular response to starvation | 0.084393 | 1.074 |
| R-HSA-8876725 | Protein methylation | 0.105040 | 0.979 |
| R-HSA-73884 | Base Excision Repair | 0.114256 | 0.942 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.077922 | 1.108 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.103055 | 0.987 |
| R-HSA-392499 | Metabolism of proteins | 0.109511 | 0.961 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.125722 | 0.901 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.074046 | 1.130 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.106754 | 0.972 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.078677 | 1.104 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.086600 | 1.062 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.067653 | 1.170 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.085143 | 1.070 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.091087 | 1.041 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.129647 | 0.887 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.080053 | 1.097 |
| R-HSA-9824446 | Viral Infection Pathways | 0.071164 | 1.148 |
| R-HSA-421270 | Cell-cell junction organization | 0.074706 | 1.127 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.088643 | 1.052 |
| R-HSA-446728 | Cell junction organization | 0.097371 | 1.012 |
| R-HSA-1237112 | Methionine salvage pathway | 0.130818 | 0.883 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.130818 | 0.883 |
| R-HSA-157579 | Telomere Maintenance | 0.131604 | 0.881 |
| R-HSA-3214847 | HATs acetylate histones | 0.135538 | 0.868 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.135538 | 0.868 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.135885 | 0.867 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.135885 | 0.867 |
| R-HSA-373753 | Nephrin family interactions | 0.135885 | 0.867 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.137515 | 0.862 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.140814 | 0.851 |
| R-HSA-2161541 | Abacavir metabolism | 0.140922 | 0.851 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.146152 | 0.835 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.150910 | 0.821 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.150910 | 0.821 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.157619 | 0.802 |
| R-HSA-112316 | Neuronal System | 0.158063 | 0.801 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.160783 | 0.794 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.163755 | 0.786 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.165677 | 0.781 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.169765 | 0.770 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.170542 | 0.768 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.170542 | 0.768 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.170542 | 0.768 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.170542 | 0.768 |
| R-HSA-2161522 | Abacavir ADME | 0.170542 | 0.768 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.174076 | 0.759 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.175380 | 0.756 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.175380 | 0.756 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.175380 | 0.756 |
| R-HSA-8949613 | Cristae formation | 0.175380 | 0.756 |
| R-HSA-373760 | L1CAM interactions | 0.176153 | 0.754 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.177072 | 0.752 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.184971 | 0.733 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.184971 | 0.733 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.186596 | 0.729 |
| R-HSA-73886 | Chromosome Maintenance | 0.186596 | 0.729 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.186596 | 0.729 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.189726 | 0.722 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.189726 | 0.722 |
| R-HSA-8939211 | ESR-mediated signaling | 0.190187 | 0.721 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.192905 | 0.715 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.194453 | 0.711 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.194453 | 0.711 |
| R-HSA-157118 | Signaling by NOTCH | 0.194614 | 0.711 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.199152 | 0.701 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.199152 | 0.701 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.199152 | 0.701 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.203824 | 0.691 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.203824 | 0.691 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.203824 | 0.691 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.208470 | 0.681 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.208470 | 0.681 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.208470 | 0.681 |
| R-HSA-9843745 | Adipogenesis | 0.211987 | 0.674 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.213089 | 0.671 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.213089 | 0.671 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.213089 | 0.671 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.213089 | 0.671 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.217680 | 0.662 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.217680 | 0.662 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.222246 | 0.653 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.222246 | 0.653 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.222246 | 0.653 |
| R-HSA-111933 | Calmodulin induced events | 0.222246 | 0.653 |
| R-HSA-111997 | CaM pathway | 0.222246 | 0.653 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.222246 | 0.653 |
| R-HSA-163685 | Integration of energy metabolism | 0.224813 | 0.648 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.226785 | 0.644 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.226785 | 0.644 |
| R-HSA-6807070 | PTEN Regulation | 0.231249 | 0.636 |
| R-HSA-73927 | Depurination | 0.231298 | 0.636 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.231298 | 0.636 |
| R-HSA-71336 | Pentose phosphate pathway | 0.235785 | 0.627 |
| R-HSA-69541 | Stabilization of p53 | 0.235785 | 0.627 |
| R-HSA-9648002 | RAS processing | 0.235785 | 0.627 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.235785 | 0.627 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.239850 | 0.620 |
| R-HSA-3371568 | Attenuation phase | 0.240246 | 0.619 |
| R-HSA-9694548 | Maturation of spike protein | 0.244681 | 0.611 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.244681 | 0.611 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.249090 | 0.604 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.249090 | 0.604 |
| R-HSA-111996 | Ca-dependent events | 0.253474 | 0.596 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.253474 | 0.596 |
| R-HSA-73928 | Depyrimidination | 0.253474 | 0.596 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.253474 | 0.596 |
| R-HSA-165159 | MTOR signalling | 0.253474 | 0.596 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.257096 | 0.590 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.259254 | 0.586 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.266475 | 0.574 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.266475 | 0.574 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.266475 | 0.574 |
| R-HSA-72766 | Translation | 0.268670 | 0.571 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.270759 | 0.567 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.270759 | 0.567 |
| R-HSA-9675135 | Diseases of DNA repair | 0.270759 | 0.567 |
| R-HSA-75153 | Apoptotic execution phase | 0.270759 | 0.567 |
| R-HSA-162587 | HIV Life Cycle | 0.272208 | 0.565 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.275017 | 0.561 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.283462 | 0.548 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.283462 | 0.548 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.283462 | 0.548 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.283462 | 0.548 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.287313 | 0.542 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.291808 | 0.535 |
| R-HSA-2514856 | The phototransduction cascade | 0.291808 | 0.535 |
| R-HSA-5619102 | SLC transporter disorders | 0.293779 | 0.532 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.295945 | 0.529 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.295945 | 0.529 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.295945 | 0.529 |
| R-HSA-1221632 | Meiotic synapsis | 0.300059 | 0.523 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.300059 | 0.523 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.300059 | 0.523 |
| R-HSA-72306 | tRNA processing | 0.302389 | 0.519 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.304148 | 0.517 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.308835 | 0.510 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.310982 | 0.507 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.312257 | 0.505 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.312257 | 0.505 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.312257 | 0.505 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.312257 | 0.505 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.317505 | 0.498 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.323925 | 0.490 |
| R-HSA-983189 | Kinesins | 0.328194 | 0.484 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.328194 | 0.484 |
| R-HSA-379724 | tRNA Aminoacylation | 0.328194 | 0.484 |
| R-HSA-109582 | Hemostasis | 0.330010 | 0.481 |
| R-HSA-112043 | PLC beta mediated events | 0.332120 | 0.479 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.336025 | 0.474 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.336025 | 0.474 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.339906 | 0.469 |
| R-HSA-373755 | Semaphorin interactions | 0.339906 | 0.469 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.349344 | 0.457 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.353567 | 0.452 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.354255 | 0.451 |
| R-HSA-112040 | G-protein mediated events | 0.355209 | 0.450 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.355209 | 0.450 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.358980 | 0.445 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.358980 | 0.445 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.366180 | 0.436 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.366456 | 0.436 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.372452 | 0.429 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.373845 | 0.427 |
| R-HSA-72172 | mRNA Splicing | 0.376621 | 0.424 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.377508 | 0.423 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.381149 | 0.419 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.384770 | 0.415 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.384770 | 0.415 |
| R-HSA-597592 | Post-translational protein modification | 0.391318 | 0.407 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.391948 | 0.407 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.393180 | 0.405 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.395236 | 0.403 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.395506 | 0.403 |
| R-HSA-4086400 | PCP/CE pathway | 0.395506 | 0.403 |
| R-HSA-9659379 | Sensory processing of sound | 0.399043 | 0.399 |
| R-HSA-68882 | Mitotic Anaphase | 0.401387 | 0.396 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.402560 | 0.395 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.402560 | 0.395 |
| R-HSA-9833482 | PKR-mediated signaling | 0.402560 | 0.395 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.403431 | 0.394 |
| R-HSA-5663205 | Infectious disease | 0.415990 | 0.381 |
| R-HSA-913531 | Interferon Signaling | 0.420556 | 0.376 |
| R-HSA-162906 | HIV Infection | 0.423688 | 0.373 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.426615 | 0.370 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.426615 | 0.370 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.429972 | 0.367 |
| R-HSA-9663891 | Selective autophagy | 0.433310 | 0.363 |
| R-HSA-9679506 | SARS-CoV Infections | 0.434835 | 0.362 |
| R-HSA-202424 | Downstream TCR signaling | 0.439927 | 0.357 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.439927 | 0.357 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.449710 | 0.347 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.449710 | 0.347 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.456139 | 0.341 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.463121 | 0.334 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.465642 | 0.332 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.465642 | 0.332 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.468773 | 0.329 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.471886 | 0.326 |
| R-HSA-422356 | Regulation of insulin secretion | 0.471886 | 0.326 |
| R-HSA-190236 | Signaling by FGFR | 0.471886 | 0.326 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.474980 | 0.323 |
| R-HSA-5688426 | Deubiquitination | 0.478457 | 0.320 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.484158 | 0.315 |
| R-HSA-111885 | Opioid Signalling | 0.490187 | 0.310 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.502039 | 0.299 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.502039 | 0.299 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.502810 | 0.299 |
| R-HSA-202403 | TCR signaling | 0.510748 | 0.292 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.513805 | 0.289 |
| R-HSA-449147 | Signaling by Interleukins | 0.523810 | 0.281 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.524929 | 0.280 |
| R-HSA-6798695 | Neutrophil degranulation | 0.531076 | 0.275 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.535981 | 0.271 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.540595 | 0.267 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.541411 | 0.266 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.542343 | 0.266 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.551027 | 0.259 |
| R-HSA-1483257 | Phospholipid metabolism | 0.551027 | 0.259 |
| R-HSA-199991 | Membrane Trafficking | 0.551645 | 0.258 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.552083 | 0.258 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.552750 | 0.257 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.554713 | 0.256 |
| R-HSA-69206 | G1/S Transition | 0.559926 | 0.252 |
| R-HSA-9909396 | Circadian clock | 0.580182 | 0.236 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.580182 | 0.236 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.582648 | 0.235 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.592370 | 0.227 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.594765 | 0.226 |
| R-HSA-1280218 | Adaptive Immune System | 0.596812 | 0.224 |
| R-HSA-1632852 | Macroautophagy | 0.604208 | 0.219 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.611147 | 0.214 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.613433 | 0.212 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.617966 | 0.209 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.620212 | 0.207 |
| R-HSA-2187338 | Visual phototransduction | 0.620212 | 0.207 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.622395 | 0.206 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.625476 | 0.204 |
| R-HSA-9609507 | Protein localization | 0.633419 | 0.198 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.634461 | 0.198 |
| R-HSA-73887 | Death Receptor Signaling | 0.635576 | 0.197 |
| R-HSA-9612973 | Autophagy | 0.639851 | 0.194 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.648254 | 0.188 |
| R-HSA-109581 | Apoptosis | 0.652383 | 0.185 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.679969 | 0.168 |
| R-HSA-168256 | Immune System | 0.680142 | 0.167 |
| R-HSA-168249 | Innate Immune System | 0.682214 | 0.166 |
| R-HSA-611105 | Respiratory electron transport | 0.685592 | 0.164 |
| R-HSA-69275 | G2/M Transition | 0.700114 | 0.155 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.703640 | 0.153 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.718935 | 0.143 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.727197 | 0.138 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.728807 | 0.137 |
| R-HSA-5357801 | Programmed Cell Death | 0.733580 | 0.135 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.734194 | 0.134 |
| R-HSA-6805567 | Keratinization | 0.735153 | 0.134 |
| R-HSA-9748784 | Drug ADME | 0.753323 | 0.123 |
| R-HSA-1643685 | Disease | 0.801165 | 0.096 |
| R-HSA-416476 | G alpha (q) signalling events | 0.812246 | 0.090 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.824191 | 0.084 |
| R-HSA-388396 | GPCR downstream signalling | 0.848521 | 0.071 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.865471 | 0.063 |
| R-HSA-1474244 | Extracellular matrix organization | 0.874015 | 0.058 |
| R-HSA-372790 | Signaling by GPCR | 0.892234 | 0.050 |
| R-HSA-418594 | G alpha (i) signalling events | 0.920518 | 0.036 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.977080 | 0.010 |
| R-HSA-1430728 | Metabolism | 0.992479 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 0.995716 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.998969 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.803 | 0.227 | -3 | 0.756 |
COT |
0.801 | 0.124 | 2 | 0.821 |
PRKD2 |
0.800 | 0.160 | -3 | 0.715 |
CLK3 |
0.800 | 0.169 | 1 | 0.752 |
PIM3 |
0.791 | 0.087 | -3 | 0.723 |
RSK2 |
0.791 | 0.109 | -3 | 0.685 |
AURC |
0.789 | 0.161 | -2 | 0.711 |
NDR2 |
0.788 | 0.061 | -3 | 0.740 |
SKMLCK |
0.788 | 0.170 | -2 | 0.844 |
MAPKAPK3 |
0.787 | 0.096 | -3 | 0.724 |
PIM1 |
0.787 | 0.106 | -3 | 0.693 |
CAMK1B |
0.786 | 0.091 | -3 | 0.746 |
SRPK1 |
0.786 | 0.090 | -3 | 0.655 |
RSK3 |
0.786 | 0.105 | -3 | 0.689 |
PKN2 |
0.785 | 0.109 | -3 | 0.736 |
NDR1 |
0.785 | 0.068 | -3 | 0.736 |
PRKD3 |
0.785 | 0.131 | -3 | 0.697 |
NUAK2 |
0.784 | 0.089 | -3 | 0.741 |
CDC7 |
0.784 | 0.033 | 1 | 0.780 |
PKN3 |
0.784 | 0.068 | -3 | 0.718 |
WNK1 |
0.784 | 0.106 | -2 | 0.838 |
P90RSK |
0.784 | 0.084 | -3 | 0.678 |
LATS2 |
0.784 | 0.075 | -5 | 0.746 |
DSTYK |
0.783 | 0.032 | 2 | 0.848 |
PKCD |
0.783 | 0.118 | 2 | 0.762 |
MOS |
0.783 | 0.072 | 1 | 0.789 |
MARK4 |
0.782 | 0.105 | 4 | 0.802 |
MAPKAPK2 |
0.782 | 0.087 | -3 | 0.677 |
MNK2 |
0.781 | 0.144 | -2 | 0.802 |
CAMK2D |
0.781 | 0.066 | -3 | 0.743 |
PKACG |
0.781 | 0.094 | -2 | 0.768 |
PRPK |
0.781 | 0.007 | -1 | 0.791 |
TSSK2 |
0.781 | 0.164 | -5 | 0.840 |
GCN2 |
0.781 | -0.061 | 2 | 0.758 |
PKACB |
0.781 | 0.138 | -2 | 0.724 |
AMPKA1 |
0.781 | 0.111 | -3 | 0.761 |
MST4 |
0.780 | 0.093 | 2 | 0.801 |
CLK1 |
0.780 | 0.125 | -3 | 0.678 |
CHAK2 |
0.779 | 0.092 | -1 | 0.837 |
RAF1 |
0.779 | -0.025 | 1 | 0.758 |
CLK2 |
0.779 | 0.146 | -3 | 0.665 |
TSSK1 |
0.778 | 0.132 | -3 | 0.773 |
CDKL1 |
0.778 | 0.041 | -3 | 0.689 |
CAMLCK |
0.778 | 0.105 | -2 | 0.833 |
CDKL5 |
0.778 | 0.074 | -3 | 0.689 |
PKCB |
0.778 | 0.118 | 2 | 0.722 |
NEK6 |
0.778 | 0.049 | -2 | 0.818 |
NIK |
0.777 | 0.088 | -3 | 0.753 |
ATR |
0.777 | 0.038 | 1 | 0.796 |
CAMK2G |
0.777 | -0.010 | 2 | 0.779 |
ULK2 |
0.777 | -0.010 | 2 | 0.732 |
CLK4 |
0.776 | 0.109 | -3 | 0.677 |
ERK5 |
0.776 | 0.098 | 1 | 0.771 |
AMPKA2 |
0.776 | 0.092 | -3 | 0.739 |
CAMK2A |
0.776 | 0.083 | 2 | 0.791 |
P70S6KB |
0.776 | 0.066 | -3 | 0.704 |
MTOR |
0.775 | -0.072 | 1 | 0.673 |
DAPK2 |
0.775 | 0.101 | -3 | 0.745 |
PRKX |
0.775 | 0.132 | -3 | 0.627 |
RIPK3 |
0.775 | 0.013 | 3 | 0.679 |
MNK1 |
0.775 | 0.116 | -2 | 0.805 |
NUAK1 |
0.775 | 0.059 | -3 | 0.719 |
SRPK2 |
0.775 | 0.048 | -3 | 0.596 |
TGFBR2 |
0.775 | 0.007 | -2 | 0.773 |
RSK4 |
0.774 | 0.090 | -3 | 0.654 |
IKKB |
0.774 | -0.077 | -2 | 0.692 |
NLK |
0.774 | 0.001 | 1 | 0.715 |
BMPR2 |
0.774 | -0.021 | -2 | 0.826 |
HIPK4 |
0.773 | 0.040 | 1 | 0.725 |
PKG2 |
0.773 | 0.131 | -2 | 0.720 |
MSK1 |
0.773 | 0.093 | -3 | 0.677 |
MSK2 |
0.773 | 0.059 | -3 | 0.667 |
HUNK |
0.773 | 0.004 | 2 | 0.761 |
PDHK4 |
0.772 | -0.193 | 1 | 0.753 |
CAMK4 |
0.772 | 0.027 | -3 | 0.733 |
LATS1 |
0.772 | 0.108 | -3 | 0.738 |
SGK3 |
0.772 | 0.113 | -3 | 0.700 |
PAK1 |
0.772 | 0.098 | -2 | 0.759 |
AURB |
0.772 | 0.113 | -2 | 0.703 |
PAK3 |
0.772 | 0.093 | -2 | 0.762 |
NEK7 |
0.772 | -0.051 | -3 | 0.690 |
MYLK4 |
0.772 | 0.099 | -2 | 0.786 |
MELK |
0.771 | 0.072 | -3 | 0.731 |
ATM |
0.771 | 0.056 | 1 | 0.766 |
CAMK2B |
0.771 | 0.050 | 2 | 0.743 |
PKCG |
0.771 | 0.072 | 2 | 0.717 |
AKT2 |
0.770 | 0.098 | -3 | 0.627 |
QSK |
0.770 | 0.073 | 4 | 0.784 |
PKCA |
0.770 | 0.079 | 2 | 0.706 |
TBK1 |
0.768 | -0.093 | 1 | 0.649 |
PHKG1 |
0.768 | 0.023 | -3 | 0.732 |
PKCH |
0.768 | 0.073 | 2 | 0.692 |
ICK |
0.768 | 0.029 | -3 | 0.725 |
MARK3 |
0.768 | 0.089 | 4 | 0.751 |
PKCZ |
0.768 | 0.078 | 2 | 0.739 |
MLK1 |
0.767 | -0.034 | 2 | 0.772 |
PAK6 |
0.767 | 0.099 | -2 | 0.714 |
PIM2 |
0.767 | 0.082 | -3 | 0.673 |
IKKE |
0.767 | -0.083 | 1 | 0.639 |
NIM1 |
0.767 | 0.007 | 3 | 0.664 |
CHK1 |
0.767 | 0.076 | -3 | 0.764 |
BMPR1B |
0.766 | 0.105 | 1 | 0.735 |
SIK |
0.766 | 0.041 | -3 | 0.692 |
GRK1 |
0.766 | 0.012 | -2 | 0.739 |
PKACA |
0.766 | 0.114 | -2 | 0.689 |
NEK9 |
0.766 | -0.026 | 2 | 0.776 |
ULK1 |
0.766 | -0.072 | -3 | 0.668 |
NEK2 |
0.766 | 0.048 | 2 | 0.765 |
PDHK1 |
0.766 | -0.154 | 1 | 0.740 |
CAMK1G |
0.766 | 0.042 | -3 | 0.673 |
QIK |
0.766 | 0.014 | -3 | 0.734 |
DCAMKL1 |
0.765 | 0.089 | -3 | 0.722 |
GRK5 |
0.765 | -0.095 | -3 | 0.683 |
SRPK3 |
0.764 | 0.019 | -3 | 0.621 |
KIS |
0.764 | -0.012 | 1 | 0.585 |
ANKRD3 |
0.764 | -0.022 | 1 | 0.786 |
WNK3 |
0.764 | -0.092 | 1 | 0.746 |
MLK2 |
0.764 | 0.001 | 2 | 0.777 |
IRE1 |
0.764 | 0.005 | 1 | 0.771 |
FAM20C |
0.763 | 0.034 | 2 | 0.562 |
MASTL |
0.763 | -0.116 | -2 | 0.759 |
GRK6 |
0.762 | -0.032 | 1 | 0.757 |
PKR |
0.762 | 0.082 | 1 | 0.794 |
IKKA |
0.762 | -0.060 | -2 | 0.667 |
MARK2 |
0.762 | 0.064 | 4 | 0.723 |
IRE2 |
0.762 | 0.011 | 2 | 0.690 |
DNAPK |
0.761 | 0.062 | 1 | 0.688 |
MLK3 |
0.761 | 0.007 | 2 | 0.723 |
AKT1 |
0.761 | 0.087 | -3 | 0.648 |
BCKDK |
0.761 | -0.119 | -1 | 0.736 |
BRSK1 |
0.761 | 0.024 | -3 | 0.722 |
CAMK1D |
0.760 | 0.063 | -3 | 0.658 |
SMG1 |
0.760 | 0.049 | 1 | 0.760 |
PKCT |
0.760 | 0.079 | 2 | 0.697 |
RIPK1 |
0.759 | -0.081 | 1 | 0.770 |
BRSK2 |
0.759 | 0.005 | -3 | 0.741 |
SSTK |
0.758 | 0.119 | 4 | 0.756 |
ALK4 |
0.758 | 0.010 | -2 | 0.794 |
TGFBR1 |
0.758 | 0.049 | -2 | 0.773 |
CHAK1 |
0.757 | 0.002 | 2 | 0.727 |
DCAMKL2 |
0.757 | 0.050 | -3 | 0.737 |
PKCI |
0.757 | 0.084 | 2 | 0.705 |
PLK1 |
0.757 | -0.023 | -2 | 0.757 |
DYRK2 |
0.757 | 0.007 | 1 | 0.617 |
PAK2 |
0.756 | 0.026 | -2 | 0.747 |
SMMLCK |
0.755 | 0.060 | -3 | 0.714 |
MARK1 |
0.755 | 0.021 | 4 | 0.763 |
PKCE |
0.755 | 0.099 | 2 | 0.699 |
AURA |
0.754 | 0.069 | -2 | 0.680 |
SNRK |
0.754 | -0.043 | 2 | 0.635 |
AKT3 |
0.754 | 0.096 | -3 | 0.582 |
MAPKAPK5 |
0.754 | -0.043 | -3 | 0.646 |
DLK |
0.754 | -0.163 | 1 | 0.733 |
PHKG2 |
0.754 | 0.016 | -3 | 0.717 |
TTBK2 |
0.753 | -0.121 | 2 | 0.652 |
ALK2 |
0.752 | 0.043 | -2 | 0.783 |
PKN1 |
0.752 | 0.055 | -3 | 0.664 |
TLK1 |
0.752 | 0.004 | -2 | 0.781 |
CAMK1A |
0.752 | 0.071 | -3 | 0.618 |
PLK3 |
0.752 | -0.027 | 2 | 0.742 |
IRAK4 |
0.752 | 0.034 | 1 | 0.779 |
HIPK1 |
0.751 | 0.034 | 1 | 0.622 |
YSK4 |
0.751 | -0.057 | 1 | 0.670 |
GRK4 |
0.751 | -0.131 | -2 | 0.764 |
CDK7 |
0.751 | -0.031 | 1 | 0.553 |
P70S6K |
0.751 | 0.017 | -3 | 0.643 |
CDK18 |
0.751 | 0.009 | 1 | 0.487 |
PERK |
0.750 | -0.026 | -2 | 0.792 |
NEK5 |
0.750 | 0.034 | 1 | 0.792 |
DRAK1 |
0.750 | -0.024 | 1 | 0.679 |
GRK7 |
0.750 | -0.000 | 1 | 0.684 |
CDK5 |
0.750 | 0.017 | 1 | 0.581 |
CDK1 |
0.750 | 0.017 | 1 | 0.513 |
ACVR2B |
0.750 | 0.012 | -2 | 0.756 |
CDK2 |
0.750 | 0.051 | 1 | 0.586 |
TLK2 |
0.750 | -0.024 | 1 | 0.771 |
MLK4 |
0.750 | -0.051 | 2 | 0.700 |
MST3 |
0.749 | 0.057 | 2 | 0.804 |
CHK2 |
0.749 | 0.053 | -3 | 0.597 |
MEK1 |
0.749 | -0.106 | 2 | 0.791 |
HRI |
0.749 | -0.041 | -2 | 0.793 |
CDK8 |
0.749 | -0.057 | 1 | 0.540 |
CDK3 |
0.749 | 0.084 | 1 | 0.451 |
VRK2 |
0.749 | -0.067 | 1 | 0.789 |
JNK2 |
0.749 | 0.015 | 1 | 0.500 |
DAPK3 |
0.748 | 0.097 | -3 | 0.706 |
ACVR2A |
0.748 | -0.009 | -2 | 0.752 |
SGK1 |
0.748 | 0.081 | -3 | 0.566 |
HIPK3 |
0.748 | 0.027 | 1 | 0.626 |
CDK19 |
0.748 | -0.045 | 1 | 0.505 |
WNK4 |
0.747 | -0.013 | -2 | 0.823 |
BRAF |
0.747 | -0.021 | -4 | 0.585 |
HIPK2 |
0.747 | 0.017 | 1 | 0.520 |
MRCKB |
0.746 | 0.095 | -3 | 0.671 |
BUB1 |
0.746 | 0.165 | -5 | 0.781 |
P38A |
0.746 | -0.008 | 1 | 0.617 |
PAK5 |
0.746 | 0.054 | -2 | 0.651 |
PLK4 |
0.745 | -0.046 | 2 | 0.568 |
JNK3 |
0.745 | -0.002 | 1 | 0.535 |
MRCKA |
0.745 | 0.083 | -3 | 0.683 |
ROCK2 |
0.744 | 0.112 | -3 | 0.712 |
BMPR1A |
0.744 | 0.054 | 1 | 0.712 |
PASK |
0.744 | 0.020 | -3 | 0.727 |
PINK1 |
0.744 | -0.088 | 1 | 0.753 |
LKB1 |
0.743 | 0.038 | -3 | 0.698 |
CDK13 |
0.742 | -0.043 | 1 | 0.529 |
DYRK4 |
0.742 | 0.019 | 1 | 0.521 |
SBK |
0.742 | 0.051 | -3 | 0.544 |
PAK4 |
0.742 | 0.058 | -2 | 0.663 |
MEKK1 |
0.742 | -0.072 | 1 | 0.732 |
CDK9 |
0.742 | -0.034 | 1 | 0.538 |
DYRK3 |
0.741 | 0.026 | 1 | 0.635 |
MEK5 |
0.741 | -0.127 | 2 | 0.779 |
DYRK1A |
0.741 | -0.009 | 1 | 0.628 |
TNIK |
0.740 | 0.097 | 3 | 0.801 |
CDK10 |
0.740 | 0.010 | 1 | 0.521 |
CDK14 |
0.740 | -0.004 | 1 | 0.529 |
CAMKK1 |
0.740 | -0.013 | -2 | 0.719 |
CAMKK2 |
0.739 | 0.003 | -2 | 0.717 |
MPSK1 |
0.739 | 0.017 | 1 | 0.729 |
CDK17 |
0.739 | -0.028 | 1 | 0.431 |
P38B |
0.739 | -0.011 | 1 | 0.547 |
DAPK1 |
0.739 | 0.065 | -3 | 0.685 |
CK1E |
0.739 | -0.067 | -3 | 0.393 |
ERK1 |
0.738 | -0.029 | 1 | 0.533 |
DMPK1 |
0.738 | 0.113 | -3 | 0.682 |
MEKK2 |
0.738 | -0.072 | 2 | 0.751 |
TAO3 |
0.738 | -0.026 | 1 | 0.694 |
LOK |
0.737 | 0.039 | -2 | 0.753 |
ZAK |
0.737 | -0.108 | 1 | 0.677 |
GRK2 |
0.737 | -0.089 | -2 | 0.655 |
NEK4 |
0.737 | -0.009 | 1 | 0.741 |
PKG1 |
0.736 | 0.071 | -2 | 0.660 |
CDK12 |
0.736 | -0.039 | 1 | 0.504 |
DYRK1B |
0.736 | -0.011 | 1 | 0.554 |
GSK3B |
0.736 | 0.000 | 4 | 0.419 |
GAK |
0.736 | 0.016 | 1 | 0.754 |
MEKK3 |
0.736 | -0.151 | 1 | 0.715 |
HGK |
0.735 | 0.027 | 3 | 0.791 |
NEK8 |
0.735 | -0.075 | 2 | 0.773 |
TAO2 |
0.734 | -0.018 | 2 | 0.807 |
P38G |
0.734 | -0.021 | 1 | 0.424 |
PDK1 |
0.734 | -0.018 | 1 | 0.732 |
ERK2 |
0.734 | -0.059 | 1 | 0.570 |
NEK1 |
0.734 | 0.028 | 1 | 0.753 |
ERK7 |
0.734 | 0.031 | 2 | 0.537 |
GCK |
0.733 | -0.010 | 1 | 0.720 |
HPK1 |
0.733 | 0.015 | 1 | 0.705 |
ROCK1 |
0.733 | 0.092 | -3 | 0.682 |
NEK11 |
0.733 | -0.103 | 1 | 0.707 |
GSK3A |
0.733 | 0.007 | 4 | 0.428 |
EEF2K |
0.733 | 0.048 | 3 | 0.770 |
MAK |
0.733 | 0.044 | -2 | 0.622 |
MINK |
0.732 | 0.016 | 1 | 0.722 |
IRAK1 |
0.732 | -0.150 | -1 | 0.706 |
CDK16 |
0.732 | -0.011 | 1 | 0.450 |
SLK |
0.732 | 0.004 | -2 | 0.685 |
MST2 |
0.732 | -0.032 | 1 | 0.732 |
PRP4 |
0.732 | -0.061 | -3 | 0.563 |
LRRK2 |
0.731 | -0.006 | 2 | 0.797 |
PBK |
0.731 | 0.046 | 1 | 0.694 |
CK1D |
0.731 | -0.071 | -3 | 0.346 |
CK2A2 |
0.731 | 0.033 | 1 | 0.592 |
MEKK6 |
0.731 | -0.009 | 1 | 0.725 |
TAK1 |
0.729 | -0.021 | 1 | 0.765 |
KHS1 |
0.729 | 0.037 | 1 | 0.711 |
CRIK |
0.729 | 0.066 | -3 | 0.648 |
CK1A2 |
0.728 | -0.078 | -3 | 0.352 |
KHS2 |
0.728 | 0.037 | 1 | 0.718 |
P38D |
0.728 | -0.014 | 1 | 0.459 |
MOK |
0.727 | 0.022 | 1 | 0.692 |
TTBK1 |
0.727 | -0.142 | 2 | 0.584 |
CK1G1 |
0.727 | -0.097 | -3 | 0.372 |
STK33 |
0.726 | -0.062 | 2 | 0.586 |
PLK2 |
0.725 | -0.026 | -3 | 0.666 |
MST1 |
0.725 | -0.047 | 1 | 0.713 |
CDK6 |
0.724 | -0.006 | 1 | 0.509 |
YSK1 |
0.723 | -0.012 | 2 | 0.760 |
MAP3K15 |
0.722 | -0.077 | 1 | 0.663 |
NEK3 |
0.721 | -0.029 | 1 | 0.691 |
GRK3 |
0.720 | -0.095 | -2 | 0.619 |
VRK1 |
0.719 | -0.060 | 2 | 0.752 |
PDHK3_TYR |
0.719 | 0.139 | 4 | 0.825 |
HASPIN |
0.719 | 0.045 | -1 | 0.711 |
CDK4 |
0.718 | -0.027 | 1 | 0.487 |
MYO3B |
0.718 | 0.043 | 2 | 0.782 |
TTK |
0.717 | 0.005 | -2 | 0.774 |
CK2A1 |
0.717 | 0.008 | 1 | 0.560 |
RIPK2 |
0.715 | -0.181 | 1 | 0.646 |
JNK1 |
0.714 | -0.044 | 1 | 0.474 |
LIMK2_TYR |
0.714 | 0.120 | -3 | 0.762 |
EPHA6 |
0.714 | 0.165 | -1 | 0.791 |
MEK2 |
0.713 | -0.143 | 2 | 0.743 |
BIKE |
0.713 | 0.038 | 1 | 0.641 |
TESK1_TYR |
0.712 | 0.016 | 3 | 0.778 |
OSR1 |
0.710 | -0.034 | 2 | 0.749 |
MYO3A |
0.710 | -0.005 | 1 | 0.728 |
MAP2K4_TYR |
0.709 | 0.008 | -1 | 0.814 |
PKMYT1_TYR |
0.709 | 0.029 | 3 | 0.754 |
MAP2K6_TYR |
0.708 | 0.005 | -1 | 0.822 |
PDHK4_TYR |
0.707 | -0.021 | 2 | 0.853 |
MAP2K7_TYR |
0.707 | -0.084 | 2 | 0.819 |
TAO1 |
0.706 | -0.037 | 1 | 0.636 |
PINK1_TYR |
0.704 | -0.083 | 1 | 0.745 |
BMPR2_TYR |
0.704 | -0.040 | -1 | 0.806 |
EPHB4 |
0.703 | 0.070 | -1 | 0.772 |
TNK2 |
0.703 | 0.081 | 3 | 0.698 |
AAK1 |
0.703 | 0.071 | 1 | 0.549 |
ASK1 |
0.701 | -0.075 | 1 | 0.640 |
DDR1 |
0.701 | 0.006 | 4 | 0.737 |
LIMK1_TYR |
0.701 | -0.042 | 2 | 0.801 |
RET |
0.701 | -0.041 | 1 | 0.722 |
PDHK1_TYR |
0.700 | -0.089 | -1 | 0.830 |
TNNI3K_TYR |
0.700 | 0.071 | 1 | 0.763 |
ROS1 |
0.699 | -0.001 | 3 | 0.702 |
TYRO3 |
0.699 | -0.006 | 3 | 0.725 |
TYK2 |
0.698 | -0.068 | 1 | 0.731 |
YANK3 |
0.698 | -0.068 | 2 | 0.394 |
ALPHAK3 |
0.697 | -0.077 | -1 | 0.716 |
MST1R |
0.696 | -0.074 | 3 | 0.730 |
ABL2 |
0.695 | 0.028 | -1 | 0.721 |
EPHA4 |
0.695 | 0.016 | 2 | 0.753 |
JAK3 |
0.694 | -0.025 | 1 | 0.689 |
JAK2 |
0.694 | -0.077 | 1 | 0.718 |
TNK1 |
0.693 | 0.014 | 3 | 0.699 |
CK1A |
0.693 | -0.099 | -3 | 0.263 |
CSF1R |
0.693 | -0.058 | 3 | 0.725 |
FGR |
0.692 | -0.039 | 1 | 0.786 |
EPHB3 |
0.692 | 0.027 | -1 | 0.751 |
EPHB1 |
0.692 | 0.000 | 1 | 0.786 |
INSRR |
0.691 | -0.041 | 3 | 0.667 |
BLK |
0.691 | 0.060 | -1 | 0.737 |
SRMS |
0.691 | -0.000 | 1 | 0.788 |
TXK |
0.691 | 0.022 | 1 | 0.739 |
ABL1 |
0.690 | 0.012 | -1 | 0.709 |
FER |
0.690 | -0.059 | 1 | 0.809 |
LCK |
0.690 | 0.014 | -1 | 0.731 |
HCK |
0.689 | -0.018 | -1 | 0.729 |
KDR |
0.689 | -0.048 | 3 | 0.689 |
EPHB2 |
0.688 | 0.010 | -1 | 0.747 |
DDR2 |
0.688 | 0.024 | 3 | 0.664 |
JAK1 |
0.688 | -0.014 | 1 | 0.658 |
YES1 |
0.687 | -0.061 | -1 | 0.750 |
EPHA7 |
0.687 | 0.014 | 2 | 0.754 |
FGFR2 |
0.686 | -0.070 | 3 | 0.699 |
ITK |
0.686 | -0.028 | -1 | 0.707 |
NEK10_TYR |
0.686 | -0.051 | 1 | 0.575 |
PDGFRB |
0.686 | -0.103 | 3 | 0.724 |
TEK |
0.685 | -0.082 | 3 | 0.669 |
AXL |
0.685 | -0.045 | 3 | 0.700 |
MERTK |
0.685 | -0.003 | 3 | 0.693 |
TEC |
0.684 | -0.022 | -1 | 0.635 |
FLT3 |
0.684 | -0.109 | 3 | 0.718 |
STLK3 |
0.684 | -0.148 | 1 | 0.651 |
KIT |
0.683 | -0.090 | 3 | 0.719 |
LTK |
0.683 | -0.023 | 3 | 0.664 |
EPHA1 |
0.683 | -0.004 | 3 | 0.696 |
BMX |
0.682 | -0.023 | -1 | 0.622 |
ALK |
0.681 | -0.053 | 3 | 0.641 |
WEE1_TYR |
0.681 | -0.065 | -1 | 0.681 |
EPHA3 |
0.681 | -0.050 | 2 | 0.726 |
FGFR1 |
0.680 | -0.095 | 3 | 0.687 |
PDGFRA |
0.680 | -0.129 | 3 | 0.730 |
MET |
0.679 | -0.083 | 3 | 0.706 |
BTK |
0.678 | -0.112 | -1 | 0.675 |
EPHA5 |
0.677 | -0.007 | 2 | 0.741 |
FLT1 |
0.677 | -0.088 | -1 | 0.784 |
FRK |
0.675 | -0.058 | -1 | 0.751 |
FYN |
0.675 | -0.030 | -1 | 0.698 |
NTRK1 |
0.675 | -0.136 | -1 | 0.743 |
PTK6 |
0.674 | -0.121 | -1 | 0.643 |
FGFR3 |
0.674 | -0.099 | 3 | 0.679 |
LYN |
0.674 | -0.059 | 3 | 0.649 |
FLT4 |
0.674 | -0.122 | 3 | 0.678 |
PTK2B |
0.673 | -0.032 | -1 | 0.672 |
INSR |
0.672 | -0.103 | 3 | 0.655 |
MATK |
0.672 | -0.076 | -1 | 0.659 |
EPHA8 |
0.672 | -0.044 | -1 | 0.723 |
ERBB2 |
0.671 | -0.147 | 1 | 0.654 |
NTRK2 |
0.670 | -0.149 | 3 | 0.670 |
PTK2 |
0.670 | -0.013 | -1 | 0.729 |
NTRK3 |
0.670 | -0.095 | -1 | 0.695 |
CK1G3 |
0.668 | -0.118 | -3 | 0.220 |
SRC |
0.664 | -0.080 | -1 | 0.692 |
EPHA2 |
0.664 | -0.040 | -1 | 0.704 |
SYK |
0.663 | -0.033 | -1 | 0.712 |
CSK |
0.662 | -0.117 | 2 | 0.752 |
EGFR |
0.662 | -0.087 | 1 | 0.564 |
YANK2 |
0.660 | -0.103 | 2 | 0.408 |
FGFR4 |
0.658 | -0.105 | -1 | 0.700 |
MUSK |
0.656 | -0.100 | 1 | 0.568 |
IGF1R |
0.655 | -0.117 | 3 | 0.588 |
ERBB4 |
0.654 | -0.061 | 1 | 0.603 |
CK1G2 |
0.647 | -0.115 | -3 | 0.300 |
FES |
0.643 | -0.109 | -1 | 0.595 |
ZAP70 |
0.638 | -0.065 | -1 | 0.621 |