Motif 956 (n=100)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00161 | SNAP23 | S34 | ochoa | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O14896 | IRF6 | S413 | ochoa|psp | Interferon regulatory factor 6 (IRF-6) | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}. |
| O15160 | POLR1C | S34 | ochoa | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft. {ECO:0000250|UniProtKB:P07703, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492, ECO:0000305|PubMed:26151409}. |
| O43815 | STRN | S264 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60664 | PLIN3 | S217 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O95259 | KCNH1 | S904 | ochoa | Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10880439, PubMed:11943152, PubMed:22732247, PubMed:25420144, PubMed:25556795, PubMed:25915598, PubMed:27005320, PubMed:27325704, PubMed:27618660, PubMed:30149017, PubMed:9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed:11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed:11943152). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25420144, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:25915598, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:30149017, ECO:0000269|PubMed:9738473}. |
| O95622 | ADCY5 | S96 | ochoa | Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:24700542, PubMed:26206488). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}. |
| P01130 | LDLR | S110 | ochoa | Low-density lipoprotein receptor (LDL receptor) | Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021). {ECO:0000269|PubMed:3005267, ECO:0000269|PubMed:30443021, ECO:0000269|PubMed:6091915}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. {ECO:0000269|PubMed:10535997, ECO:0000269|PubMed:12615904}.; FUNCTION: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. {ECO:0000269|PubMed:23589850}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. {ECO:0000269|PubMed:11100124}.; FUNCTION: (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). {ECO:0000269|PubMed:38182887}.; FUNCTION: (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus. {ECO:0000269|PubMed:38245515}. |
| P04083 | ANXA1 | S189 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04839 | CYBB | S486 | psp | NADPH oxidase 2 (EC 1.6.3.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Cytochrome b-245 heavy chain) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) | Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:15338276, PubMed:36241643, PubMed:36413210, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable) (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:19028840, PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). NADPH oxidase complex assembly is impaired through interaction with NRROS (By similarity). {ECO:0000250|UniProtKB:P13498, ECO:0000250|UniProtKB:Q61093, ECO:0000269|PubMed:15338276, ECO:0000269|PubMed:19028840, ECO:0000269|PubMed:36241643, ECO:0000269|PubMed:36413210, ECO:0000269|PubMed:38355798, ECO:0000305|PubMed:36241643}. |
| P05107 | ITGB2 | S346 | ochoa | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}. |
| P06734 | FCER2 | S254 | psp | Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003). {ECO:0000269|PubMed:2167225, ECO:0000269|PubMed:7544003}. |
| P08574 | CYC1 | S182 | ochoa | Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. {ECO:0000250|UniProtKB:P07143}. |
| P09874 | PARP1 | S786 | ochoa|psp | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P19634 | SLC9A1 | S602 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P20810 | CAST | S561 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21333 | FLNA | S215 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S219 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22681 | CBL | S714 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P25054 | APC | S1857 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25786 | PSMA1 | S106 | ochoa | Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P26640 | VARS1 | S570 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P30086 | PEBP1 | S75 | ochoa | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P35222 | CTNNB1 | S718 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35367 | HRH1 | S318 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P38398 | BRCA1 | S398 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P43121 | MCAM | S606 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P46821 | MAP1B | S1869 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46934 | NEDD4 | S888 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P51116 | FXR2 | S654 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P53355 | DAPK1 | S324 | ochoa | Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing. |
| P53778 | MAPK12 | S180 | ochoa | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}. |
| P55287 | CDH11 | S714 | ochoa | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546). {ECO:0000269|PubMed:33811546}. |
| P60842 | EIF4A1 | S323 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P63241 | EIF5A | S75 | ochoa | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| P98171 | ARHGAP4 | S413 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q00537 | CDK17 | S92 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q00872 | MYBPC1 | S427 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q09028 | RBBP4 | S146 | ochoa | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q09666 | AHNAK | S5293 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12802 | AKAP13 | S1932 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12955 | ANK3 | S4181 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q14008 | CKAP5 | S845 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14161 | GIT2 | S384 | psp | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14240 | EIF4A2 | S324 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14315 | FLNC | S1637 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14919 | DRAP1 | S89 | ochoa | Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
| Q16576 | RBBP7 | S145 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q3V6T2 | CCDC88A | S1439 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q53T59 | HS1BP3 | S254 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5TH69 | ARFGEF3 | S597 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VUA4 | ZNF318 | S141 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q6IS14 | EIF5AL1 | S75 | ochoa | Eukaryotic translation initiation factor 5A-1-like (eIF-5A-1-like) (eIF-5A1-like) (Eukaryotic initiation factor 5A isoform 1-like) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241}. |
| Q6P0Q8 | MAST2 | S806 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6ZUJ8 | PIK3AP1 | S426 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q71F56 | MED13L | S1642 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q7Z3G6 | PRICKLE2 | S740 | ochoa | Prickle-like protein 2 | None |
| Q86XA9 | HEATR5A | S1328 | ochoa | HEAT repeat-containing protein 5A | None |
| Q8IW50 | FAM219A | S102 | ochoa | Protein FAM219A | None |
| Q8IXS8 | HYCC2 | S416 | ochoa | Hyccin 2 | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}. |
| Q8IYI6 | EXOC8 | S147 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8NEB9 | PIK3C3 | S249 | ochoa|psp | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NEY1 | NAV1 | S391 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8TC44 | POC1B | S398 | ochoa | POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) | Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). Acts as a positive regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:20008567, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:25044745, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:37934472}. |
| Q8TDD1 | DDX54 | S71 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TEV9 | SMCR8 | S639 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WU90 | ZC3H15 | S328 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q92785 | DPF2 | S151 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92879 | CELF1 | S28 | ochoa|psp | CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}. |
| Q92900 | UPF1 | S1089 | psp | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q92900 | UPF1 | S1107 | ochoa|psp | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q96AC1 | FERMT2 | S363 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96LA6 | FCRL1 | S67 | ochoa | Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a) | Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses (PubMed:15479727). Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation (By similarity). Also plays a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q8R4Y0, ECO:0000269|PubMed:15479727}. |
| Q96P48 | ARAP1 | S1428 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}. |
| Q99497 | PARK7 | S47 | ochoa | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) | Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}. |
| Q9C0C2 | TNKS1BP1 | S920 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZV4 | EIF5A2 | S75 | ochoa | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}. |
| Q9H4G0 | EPB41L1 | S667 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H706 | GAREM1 | S759 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9NQW6 | ANLN | S553 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQZ2 | UTP3 | S42 | ochoa | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}. |
| Q9NWH9 | SLTM | S294 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NWQ8 | PAG1 | S170 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9P1Y6 | PHRF1 | S446 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9UHG2 | PCSK1N | S209 | ochoa | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}. |
| Q9Y2W2 | WBP11 | S600 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y2X7 | GIT1 | S410 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y6B6 | SAR1B | S143 | ochoa | Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B) | Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII (PubMed:23433038, PubMed:32358066, PubMed:33186557, PubMed:36369712). The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:23433038, PubMed:32358066, PubMed:33186557). In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis (PubMed:32358066, PubMed:33186557). In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B (PubMed:34290409). {ECO:0000269|PubMed:23433038, ECO:0000269|PubMed:32358066, ECO:0000269|PubMed:33186557, ECO:0000269|PubMed:34290409, ECO:0000269|PubMed:36369712}. |
| Q9Y6C9 | MTCH2 | S80 | ochoa | Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein) | Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity). {ECO:0000250|UniProtKB:Q791V5, ECO:0000269|PubMed:36264797}. |
| Q9Y6D5 | ARFGEF2 | S1534 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| P50395 | GDI2 | S401 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| Q13564 | NAE1 | S198 | Sugiyama | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1) | Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:10722740, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:36608681}. |
| Q16658 | FSCN1 | S237 | Sugiyama | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| P43034 | PAFAH1B1 | S157 | Sugiyama | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
| Q9NYU2 | UGGT1 | S445 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| Q05513 | PRKCZ | S228 | Sugiyama | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q05513 | PRKCZ | S482 | Sugiyama | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q13873 | BMPR2 | S194 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q8N568 | DCLK2 | S129 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q9UBE8 | NLK | S237 | Sugiyama | Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) | Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:12482967, PubMed:14960582, PubMed:15004007, PubMed:15764709, PubMed:20061393, PubMed:20874444, PubMed:21454679). Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 (PubMed:15004007, PubMed:15764709). Negative regulator of the canonical Wnt/beta-catenin signaling pathway (PubMed:12482967). Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 (PubMed:21454679). Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes (PubMed:12482967, PubMed:21454679). Negative regulator of the Notch signaling pathway (PubMed:20118921). Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 (PubMed:20118921). Negative regulator of the MYB family of transcription factors (PubMed:15082531). Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP (PubMed:15082531). Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself (PubMed:15082531). Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (PubMed:15004007, PubMed:15764709). Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes (PubMed:26588989). {ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582, ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15082531, ECO:0000269|PubMed:15764709, ECO:0000269|PubMed:20061393, ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613, ECO:0000269|PubMed:26588989}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.299849e-07 | 6.638 |
| R-HSA-446728 | Cell junction organization | 2.265868e-07 | 6.645 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.302465e-07 | 6.366 |
| R-HSA-1500931 | Cell-Cell communication | 8.629601e-07 | 6.064 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 3.531934e-06 | 5.452 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.465195e-06 | 5.460 |
| R-HSA-418990 | Adherens junctions interactions | 8.364514e-06 | 5.078 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.155712e-05 | 4.666 |
| R-HSA-421270 | Cell-cell junction organization | 2.524622e-05 | 4.598 |
| R-HSA-162582 | Signal Transduction | 3.534651e-05 | 4.452 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 9.353596e-05 | 4.029 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.183118e-04 | 3.927 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.395687e-04 | 3.855 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.581392e-04 | 3.446 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.725382e-04 | 3.326 |
| R-HSA-429947 | Deadenylation of mRNA | 1.332414e-03 | 2.875 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.531949e-03 | 2.815 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.760623e-03 | 2.754 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.518068e-03 | 2.599 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 2.856532e-03 | 2.544 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 2.856532e-03 | 2.544 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 3.383880e-03 | 2.471 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.405644e-03 | 2.468 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.133233e-03 | 2.504 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.551125e-03 | 2.342 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 5.214799e-03 | 2.283 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 5.906063e-03 | 2.229 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 5.906063e-03 | 2.229 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 5.906063e-03 | 2.229 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 5.906063e-03 | 2.229 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 5.906063e-03 | 2.229 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 5.906063e-03 | 2.229 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.978115e-03 | 2.303 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 5.906063e-03 | 2.229 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 7.054644e-03 | 2.152 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.527661e-03 | 2.123 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 8.214498e-03 | 2.085 |
| R-HSA-109581 | Apoptosis | 9.385291e-03 | 2.028 |
| R-HSA-168256 | Immune System | 1.065546e-02 | 1.972 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.181860e-02 | 1.927 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.213125e-02 | 1.916 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.213125e-02 | 1.916 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.229317e-02 | 1.910 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.278698e-02 | 1.893 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.405995e-02 | 1.852 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.405995e-02 | 1.852 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.405995e-02 | 1.852 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.369746e-02 | 1.863 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.598688e-02 | 1.796 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.484497e-02 | 1.828 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.599159e-02 | 1.796 |
| R-HSA-449147 | Signaling by Interleukins | 1.666027e-02 | 1.778 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.834785e-02 | 1.736 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.834785e-02 | 1.736 |
| R-HSA-194138 | Signaling by VEGF | 1.792189e-02 | 1.747 |
| R-HSA-4086398 | Ca2+ pathway | 2.023899e-02 | 1.694 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.101627e-02 | 1.677 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.324376e-02 | 1.634 |
| R-HSA-525793 | Myogenesis | 2.195617e-02 | 1.658 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.324376e-02 | 1.634 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.155726e-02 | 1.666 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.195617e-02 | 1.658 |
| R-HSA-5357801 | Programmed Cell Death | 2.237239e-02 | 1.650 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.362101e-02 | 1.627 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.386113e-02 | 1.622 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.502370e-02 | 1.602 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.522281e-02 | 1.598 |
| R-HSA-6807070 | PTEN Regulation | 2.538200e-02 | 1.595 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.590966e-02 | 1.587 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.012809e-02 | 1.521 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.012809e-02 | 1.521 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.012809e-02 | 1.521 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.308131e-02 | 1.480 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.459882e-02 | 1.461 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.204223e-02 | 1.494 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.459882e-02 | 1.461 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.207282e-02 | 1.494 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 3.043309e-02 | 1.517 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.159092e-02 | 1.500 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.446962e-02 | 1.463 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 3.478328e-02 | 1.459 |
| R-HSA-390650 | Histamine receptors | 3.478328e-02 | 1.459 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 4.159465e-02 | 1.381 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 4.835837e-02 | 1.316 |
| R-HSA-8964026 | Chylomicron clearance | 6.174419e-02 | 1.209 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 6.836694e-02 | 1.165 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 6.836694e-02 | 1.165 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 6.836694e-02 | 1.165 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 7.494335e-02 | 1.125 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 8.147374e-02 | 1.089 |
| R-HSA-9613354 | Lipophagy | 8.147374e-02 | 1.089 |
| R-HSA-9700645 | ALK mutants bind TKIs | 8.147374e-02 | 1.089 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 8.795843e-02 | 1.056 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 9.439774e-02 | 1.025 |
| R-HSA-4839744 | Signaling by APC mutants | 9.439774e-02 | 1.025 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 9.439774e-02 | 1.025 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 9.439774e-02 | 1.025 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 9.439774e-02 | 1.025 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.007920e-01 | 0.997 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 1.134465e-01 | 0.945 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.259245e-01 | 0.900 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.259245e-01 | 0.900 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 1.259245e-01 | 0.900 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.259245e-01 | 0.900 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 1.259245e-01 | 0.900 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.382284e-01 | 0.859 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.771338e-02 | 1.424 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.503606e-01 | 0.823 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.563630e-01 | 0.806 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.563630e-01 | 0.806 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.563630e-01 | 0.806 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.623234e-01 | 0.790 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.623234e-01 | 0.790 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.623234e-01 | 0.790 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.623234e-01 | 0.790 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.623234e-01 | 0.790 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.623234e-01 | 0.790 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.801376e-02 | 1.167 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.998541e-02 | 1.155 |
| R-HSA-72649 | Translation initiation complex formation | 7.197571e-02 | 1.143 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.972193e-01 | 0.705 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.601082e-02 | 1.119 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.085280e-01 | 0.681 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.196787e-01 | 0.658 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 9.067004e-02 | 1.043 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 9.067004e-02 | 1.043 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 9.718806e-02 | 1.012 |
| R-HSA-390522 | Striated Muscle Contraction | 2.468790e-01 | 0.608 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.128841e-01 | 0.947 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.522052e-01 | 0.598 |
| R-HSA-380287 | Centrosome maturation | 1.174833e-01 | 0.930 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.435570e-01 | 0.843 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.435570e-01 | 0.843 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.508676e-01 | 0.821 |
| R-HSA-182971 | EGFR downregulation | 2.306738e-01 | 0.637 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.557823e-01 | 0.807 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.007920e-01 | 0.997 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.382284e-01 | 0.859 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 8.011630e-02 | 1.096 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.835837e-02 | 1.316 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.930955e-02 | 1.406 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.522052e-01 | 0.598 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.476500e-02 | 1.261 |
| R-HSA-774815 | Nucleosome assembly | 5.476500e-02 | 1.261 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.563630e-01 | 0.806 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 7.494335e-02 | 1.125 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.415152e-01 | 0.617 |
| R-HSA-3928664 | Ephrin signaling | 1.503606e-01 | 0.823 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.259245e-01 | 0.900 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.468790e-01 | 0.608 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.415152e-01 | 0.617 |
| R-HSA-5693538 | Homology Directed Repair | 2.400556e-01 | 0.620 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.858511e-01 | 0.731 |
| R-HSA-9764561 | Regulation of CDH1 Function | 7.805493e-02 | 1.108 |
| R-HSA-1538133 | G0 and Early G1 | 2.361135e-01 | 0.627 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 8.795843e-02 | 1.056 |
| R-HSA-192814 | vRNA Synthesis | 9.439774e-02 | 1.025 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.007920e-01 | 0.997 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.007920e-01 | 0.997 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.007920e-01 | 0.997 |
| R-HSA-164378 | PKA activation in glucagon signalling | 1.503606e-01 | 0.823 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.424842e-02 | 1.354 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.741193e-01 | 0.759 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.799553e-01 | 0.745 |
| R-HSA-9865881 | Complex III assembly | 1.915051e-01 | 0.718 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.306738e-01 | 0.637 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.306738e-01 | 0.637 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.038350e-01 | 0.984 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 2.468790e-01 | 0.608 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.468790e-01 | 0.608 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.522052e-01 | 0.598 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.522052e-01 | 0.598 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.681989e-01 | 0.774 |
| R-HSA-201451 | Signaling by BMP | 2.085280e-01 | 0.681 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.251956e-01 | 0.647 |
| R-HSA-9843745 | Adipogenesis | 8.708861e-02 | 1.060 |
| R-HSA-8964038 | LDL clearance | 1.799553e-01 | 0.745 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.348419e-01 | 0.629 |
| R-HSA-177929 | Signaling by EGFR | 7.601082e-02 | 1.119 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.729214e-01 | 0.762 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.348419e-01 | 0.629 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.623234e-01 | 0.790 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 7.494335e-02 | 1.125 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.197074e-01 | 0.922 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.259245e-01 | 0.900 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.503606e-01 | 0.823 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.799553e-01 | 0.745 |
| R-HSA-3214815 | HDACs deacetylate histones | 7.398429e-02 | 1.131 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.468790e-01 | 0.608 |
| R-HSA-8951664 | Neddylation | 9.263773e-02 | 1.033 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.134465e-01 | 0.945 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.393059e-01 | 0.856 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.533210e-01 | 0.814 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.883948e-01 | 0.725 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.424842e-02 | 1.354 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.424842e-02 | 1.354 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.141230e-01 | 0.669 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.196787e-01 | 0.658 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.522052e-01 | 0.598 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 8.640048e-02 | 1.063 |
| R-HSA-195721 | Signaling by WNT | 7.618536e-02 | 1.118 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 8.147374e-02 | 1.089 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 8.795843e-02 | 1.056 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 9.439774e-02 | 1.025 |
| R-HSA-9834899 | Specification of the neural plate border | 1.563630e-01 | 0.806 |
| R-HSA-9710421 | Defective pyroptosis | 5.116866e-02 | 1.291 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.972193e-01 | 0.705 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.361135e-01 | 0.627 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 2.415152e-01 | 0.617 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.387271e-01 | 0.858 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.089052e-01 | 0.680 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.089052e-01 | 0.680 |
| R-HSA-9824272 | Somitogenesis | 5.476500e-02 | 1.261 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.478869e-01 | 0.606 |
| R-HSA-9766229 | Degradation of CDH1 | 6.221429e-02 | 1.206 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.972193e-01 | 0.705 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.972193e-01 | 0.705 |
| R-HSA-9612973 | Autophagy | 1.265565e-01 | 0.898 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.085280e-01 | 0.681 |
| R-HSA-9663891 | Selective autophagy | 1.508676e-01 | 0.821 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.414087e-02 | 1.266 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.986169e-01 | 0.702 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.986169e-01 | 0.702 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.259245e-01 | 0.900 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.028935e-01 | 0.693 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.476500e-02 | 1.261 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.869676e-01 | 0.728 |
| R-HSA-199991 | Membrane Trafficking | 4.843638e-02 | 1.315 |
| R-HSA-8948747 | Regulation of PTEN localization | 6.836694e-02 | 1.165 |
| R-HSA-425986 | Sodium/Proton exchangers | 7.494335e-02 | 1.125 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.134465e-01 | 0.945 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.259245e-01 | 0.900 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.320980e-01 | 0.879 |
| R-HSA-163615 | PKA activation | 1.503606e-01 | 0.823 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.306738e-01 | 0.637 |
| R-HSA-1632852 | Macroautophagy | 1.024549e-01 | 0.989 |
| R-HSA-69275 | G2/M Transition | 5.849127e-02 | 1.233 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.766206e-02 | 1.322 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.017510e-02 | 1.221 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.339084e-01 | 0.873 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 5.507478e-02 | 1.259 |
| R-HSA-8963888 | Chylomicron assembly | 9.439774e-02 | 1.025 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.197074e-01 | 0.922 |
| R-HSA-171007 | p38MAPK events | 1.259245e-01 | 0.900 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.623234e-01 | 0.790 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 8.428940e-02 | 1.074 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.468790e-01 | 0.608 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.522052e-01 | 0.598 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.522052e-01 | 0.598 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.114863e-01 | 0.675 |
| R-HSA-5617833 | Cilium Assembly | 1.851953e-01 | 0.732 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.291810e-01 | 0.889 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.681035e-02 | 1.330 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.405825e-02 | 1.130 |
| R-HSA-2160916 | Hyaluronan degradation | 1.972193e-01 | 0.705 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.028935e-01 | 0.693 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.028935e-01 | 0.693 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 1.632111e-01 | 0.787 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.355569e-01 | 0.868 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.858511e-01 | 0.731 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.623234e-01 | 0.790 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.998541e-02 | 1.155 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.741193e-01 | 0.759 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.443158e-01 | 0.841 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 1.682421e-01 | 0.774 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.799553e-01 | 0.745 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.060779e-01 | 0.974 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.083339e-01 | 0.965 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.116866e-02 | 1.291 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.128841e-01 | 0.947 |
| R-HSA-2142845 | Hyaluronan metabolism | 2.522052e-01 | 0.598 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.960547e-01 | 0.708 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.682421e-01 | 0.774 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.682421e-01 | 0.774 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.214011e-01 | 0.655 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.782512e-01 | 0.749 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 8.147374e-02 | 1.089 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.197074e-01 | 0.922 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.320980e-01 | 0.879 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.743028e-02 | 1.324 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.960547e-01 | 0.708 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.081427e-02 | 1.150 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.147374e-02 | 1.089 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.320980e-01 | 0.879 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 2.085280e-01 | 0.681 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.415152e-01 | 0.617 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.727172e-02 | 1.012 |
| R-HSA-1280218 | Adaptive Immune System | 3.903102e-02 | 1.409 |
| R-HSA-9830364 | Formation of the nephric duct | 1.972193e-01 | 0.705 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.106027e-01 | 0.956 |
| R-HSA-1266738 | Developmental Biology | 2.262835e-01 | 0.645 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.494335e-02 | 1.125 |
| R-HSA-1502540 | Signaling by Activin | 1.259245e-01 | 0.900 |
| R-HSA-9629569 | Protein hydroxylation | 1.623234e-01 | 0.790 |
| R-HSA-167044 | Signalling to RAS | 1.682421e-01 | 0.774 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.060779e-01 | 0.974 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.244370e-01 | 0.649 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.028935e-01 | 0.693 |
| R-HSA-68882 | Mitotic Anaphase | 2.344285e-01 | 0.630 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.503606e-01 | 0.823 |
| R-HSA-180292 | GAB1 signalosome | 1.503606e-01 | 0.823 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.915051e-01 | 0.718 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.915051e-01 | 0.718 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.028935e-01 | 0.693 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.362986e-01 | 0.627 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.436348e-02 | 1.074 |
| R-HSA-1181150 | Signaling by NODAL | 1.623234e-01 | 0.790 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.741193e-01 | 0.759 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.085280e-01 | 0.681 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.306738e-01 | 0.637 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.291810e-01 | 0.889 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.322376e-01 | 0.634 |
| R-HSA-73886 | Chromosome Maintenance | 2.478869e-01 | 0.606 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 7.601082e-02 | 1.119 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.972193e-01 | 0.705 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.522052e-01 | 0.598 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.330549e-01 | 0.876 |
| R-HSA-8848021 | Signaling by PTK6 | 9.067004e-02 | 1.043 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 9.067004e-02 | 1.043 |
| R-HSA-9733709 | Cardiogenesis | 2.415152e-01 | 0.617 |
| R-HSA-9833110 | RSV-host interactions | 1.986169e-01 | 0.702 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.269764e-01 | 0.644 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.799553e-01 | 0.745 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 8.428940e-02 | 1.074 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.149578e-02 | 1.089 |
| R-HSA-8983711 | OAS antiviral response | 1.071415e-01 | 0.970 |
| R-HSA-6783783 | Interleukin-10 signaling | 1.244690e-01 | 0.905 |
| R-HSA-264876 | Insulin processing | 2.085280e-01 | 0.681 |
| R-HSA-202403 | TCR signaling | 2.140706e-01 | 0.669 |
| R-HSA-913531 | Interferon Signaling | 6.798891e-02 | 1.168 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.443158e-01 | 0.841 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.443158e-01 | 0.841 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.522052e-01 | 0.598 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.060779e-01 | 0.974 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 1.915051e-01 | 0.718 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.689330e-02 | 1.061 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.134465e-01 | 0.945 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.909434e-01 | 0.719 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.400556e-01 | 0.620 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.594341e-02 | 1.338 |
| R-HSA-75153 | Apoptotic execution phase | 5.659583e-02 | 1.247 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.503606e-01 | 0.823 |
| R-HSA-2980736 | Peptide hormone metabolism | 2.374480e-01 | 0.624 |
| R-HSA-6783589 | Interleukin-6 family signaling | 1.915051e-01 | 0.718 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.799553e-01 | 0.745 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.296353e-01 | 0.639 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.315353e-01 | 0.881 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.328768e-01 | 0.877 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.531131e-01 | 0.597 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.574940e-01 | 0.589 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.574940e-01 | 0.589 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.574940e-01 | 0.589 |
| R-HSA-169911 | Regulation of Apoptosis | 2.574940e-01 | 0.589 |
| R-HSA-187687 | Signalling to ERKs | 2.574940e-01 | 0.589 |
| R-HSA-69206 | G1/S Transition | 2.609576e-01 | 0.583 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.627458e-01 | 0.580 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.627458e-01 | 0.580 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.627458e-01 | 0.580 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.627458e-01 | 0.580 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.627458e-01 | 0.580 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.627458e-01 | 0.580 |
| R-HSA-163560 | Triglyceride catabolism | 2.627458e-01 | 0.580 |
| R-HSA-111933 | Calmodulin induced events | 2.627458e-01 | 0.580 |
| R-HSA-111997 | CaM pathway | 2.627458e-01 | 0.580 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.627458e-01 | 0.580 |
| R-HSA-69481 | G2/M Checkpoints | 2.661892e-01 | 0.575 |
| R-HSA-1296072 | Voltage gated Potassium channels | 2.679607e-01 | 0.572 |
| R-HSA-4641258 | Degradation of DVL | 2.679607e-01 | 0.572 |
| R-HSA-4641257 | Degradation of AXIN | 2.679607e-01 | 0.572 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.679607e-01 | 0.572 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.679607e-01 | 0.572 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.679607e-01 | 0.572 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.731391e-01 | 0.564 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.740367e-01 | 0.562 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.782812e-01 | 0.556 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.782812e-01 | 0.556 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.782812e-01 | 0.556 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 2.782812e-01 | 0.556 |
| R-HSA-69541 | Stabilization of p53 | 2.782812e-01 | 0.556 |
| R-HSA-157118 | Signaling by NOTCH | 2.799308e-01 | 0.553 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.833872e-01 | 0.548 |
| R-HSA-9646399 | Aggrephagy | 2.833872e-01 | 0.548 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.833872e-01 | 0.548 |
| R-HSA-5260271 | Diseases of Immune System | 2.833872e-01 | 0.548 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.833872e-01 | 0.548 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.833872e-01 | 0.548 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.884574e-01 | 0.540 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.884574e-01 | 0.540 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.884574e-01 | 0.540 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.884574e-01 | 0.540 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.884574e-01 | 0.540 |
| R-HSA-9607240 | FLT3 Signaling | 2.884574e-01 | 0.540 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.884574e-01 | 0.540 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.934920e-01 | 0.532 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.934920e-01 | 0.532 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.934920e-01 | 0.532 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.934920e-01 | 0.532 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.934920e-01 | 0.532 |
| R-HSA-4839726 | Chromatin organization | 2.972332e-01 | 0.527 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.975491e-01 | 0.526 |
| R-HSA-991365 | Activation of GABAB receptors | 2.984913e-01 | 0.525 |
| R-HSA-977444 | GABA B receptor activation | 2.984913e-01 | 0.525 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.984913e-01 | 0.525 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.984913e-01 | 0.525 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 2.984913e-01 | 0.525 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.984913e-01 | 0.525 |
| R-HSA-111996 | Ca-dependent events | 2.984913e-01 | 0.525 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.001562e-01 | 0.523 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.034556e-01 | 0.518 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.034556e-01 | 0.518 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.034556e-01 | 0.518 |
| R-HSA-9907900 | Proteasome assembly | 3.083850e-01 | 0.511 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.083850e-01 | 0.511 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.083850e-01 | 0.511 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.083850e-01 | 0.511 |
| R-HSA-5688426 | Deubiquitination | 3.088075e-01 | 0.510 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.131673e-01 | 0.504 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.132798e-01 | 0.504 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.132798e-01 | 0.504 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.132798e-01 | 0.504 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.132798e-01 | 0.504 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.132798e-01 | 0.504 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.132798e-01 | 0.504 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.132798e-01 | 0.504 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.132798e-01 | 0.504 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.132798e-01 | 0.504 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.157638e-01 | 0.501 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.181404e-01 | 0.497 |
| R-HSA-9675135 | Diseases of DNA repair | 3.181404e-01 | 0.497 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.181404e-01 | 0.497 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.181404e-01 | 0.497 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.181404e-01 | 0.497 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.181404e-01 | 0.497 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.229668e-01 | 0.491 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.229668e-01 | 0.491 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.235405e-01 | 0.490 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.261281e-01 | 0.487 |
| R-HSA-9634597 | GPER1 signaling | 3.277593e-01 | 0.484 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.277593e-01 | 0.484 |
| R-HSA-425410 | Metal ion SLC transporters | 3.277593e-01 | 0.484 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.287131e-01 | 0.483 |
| R-HSA-69242 | S Phase | 3.287131e-01 | 0.483 |
| R-HSA-9758941 | Gastrulation | 3.312956e-01 | 0.480 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.325182e-01 | 0.478 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.325182e-01 | 0.478 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.325182e-01 | 0.478 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.338753e-01 | 0.476 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.339327e-01 | 0.476 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.364523e-01 | 0.473 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.372437e-01 | 0.472 |
| R-HSA-109704 | PI3K Cascade | 3.372437e-01 | 0.472 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.390265e-01 | 0.470 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.415977e-01 | 0.466 |
| R-HSA-912446 | Meiotic recombination | 3.419361e-01 | 0.466 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.419361e-01 | 0.466 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.419361e-01 | 0.466 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.419361e-01 | 0.466 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.465955e-01 | 0.460 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.465955e-01 | 0.460 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.465955e-01 | 0.460 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.465955e-01 | 0.460 |
| R-HSA-1221632 | Meiotic synapsis | 3.512222e-01 | 0.454 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.512222e-01 | 0.454 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.512222e-01 | 0.454 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.512222e-01 | 0.454 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.544063e-01 | 0.450 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.558164e-01 | 0.449 |
| R-HSA-877300 | Interferon gamma signaling | 3.569580e-01 | 0.447 |
| R-HSA-392499 | Metabolism of proteins | 3.571524e-01 | 0.447 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.603784e-01 | 0.443 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.603784e-01 | 0.443 |
| R-HSA-418597 | G alpha (z) signalling events | 3.603784e-01 | 0.443 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.609613e-01 | 0.443 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.649084e-01 | 0.438 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.649084e-01 | 0.438 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.649084e-01 | 0.438 |
| R-HSA-5654736 | Signaling by FGFR1 | 3.649084e-01 | 0.438 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.649084e-01 | 0.438 |
| R-HSA-112399 | IRS-mediated signalling | 3.694066e-01 | 0.432 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.694066e-01 | 0.432 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.738731e-01 | 0.427 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.738731e-01 | 0.427 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.744264e-01 | 0.427 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.783084e-01 | 0.422 |
| R-HSA-8979227 | Triglyceride metabolism | 3.783084e-01 | 0.422 |
| R-HSA-977443 | GABA receptor activation | 3.827124e-01 | 0.417 |
| R-HSA-351202 | Metabolism of polyamines | 3.827124e-01 | 0.417 |
| R-HSA-379724 | tRNA Aminoacylation | 3.827124e-01 | 0.417 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.870856e-01 | 0.412 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.870856e-01 | 0.412 |
| R-HSA-445717 | Aquaporin-mediated transport | 3.870856e-01 | 0.412 |
| R-HSA-112043 | PLC beta mediated events | 3.870856e-01 | 0.412 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.878392e-01 | 0.411 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.914280e-01 | 0.407 |
| R-HSA-1268020 | Mitochondrial protein import | 3.914280e-01 | 0.407 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.914280e-01 | 0.407 |
| R-HSA-72766 | Translation | 3.948813e-01 | 0.404 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.957399e-01 | 0.403 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.957399e-01 | 0.403 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.000216e-01 | 0.398 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.000216e-01 | 0.398 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.000216e-01 | 0.398 |
| R-HSA-8953854 | Metabolism of RNA | 4.035590e-01 | 0.394 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.042732e-01 | 0.393 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.042732e-01 | 0.393 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.042732e-01 | 0.393 |
| R-HSA-597592 | Post-translational protein modification | 4.110424e-01 | 0.386 |
| R-HSA-2559583 | Cellular Senescence | 4.120778e-01 | 0.385 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.126869e-01 | 0.384 |
| R-HSA-112040 | G-protein mediated events | 4.126869e-01 | 0.384 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.126869e-01 | 0.384 |
| R-HSA-9830369 | Kidney development | 4.126869e-01 | 0.384 |
| R-HSA-1640170 | Cell Cycle | 4.128779e-01 | 0.384 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.168495e-01 | 0.380 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.250872e-01 | 0.372 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.250872e-01 | 0.372 |
| R-HSA-9824446 | Viral Infection Pathways | 4.258050e-01 | 0.371 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.291627e-01 | 0.367 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.291627e-01 | 0.367 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.291627e-01 | 0.367 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.291627e-01 | 0.367 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.291627e-01 | 0.367 |
| R-HSA-975634 | Retinoid metabolism and transport | 4.291627e-01 | 0.367 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.332095e-01 | 0.363 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.332095e-01 | 0.363 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.372279e-01 | 0.359 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.372279e-01 | 0.359 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.388486e-01 | 0.358 |
| R-HSA-6798695 | Neutrophil degranulation | 4.393955e-01 | 0.357 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.412181e-01 | 0.355 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.412181e-01 | 0.355 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.412181e-01 | 0.355 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 4.412181e-01 | 0.355 |
| R-HSA-68877 | Mitotic Prometaphase | 4.435650e-01 | 0.353 |
| R-HSA-5689603 | UCH proteinases | 4.491145e-01 | 0.348 |
| R-HSA-9609690 | HCMV Early Events | 4.507013e-01 | 0.346 |
| R-HSA-112316 | Neuronal System | 4.566514e-01 | 0.340 |
| R-HSA-216083 | Integrin cell surface interactions | 4.569002e-01 | 0.340 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.569002e-01 | 0.340 |
| R-HSA-5619084 | ABC transporter disorders | 4.569002e-01 | 0.340 |
| R-HSA-4086400 | PCP/CE pathway | 4.569002e-01 | 0.340 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.601366e-01 | 0.337 |
| R-HSA-9659379 | Sensory processing of sound | 4.607521e-01 | 0.337 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.607521e-01 | 0.337 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.645769e-01 | 0.333 |
| R-HSA-6806834 | Signaling by MET | 4.645769e-01 | 0.333 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.648193e-01 | 0.333 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.683748e-01 | 0.329 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 4.683748e-01 | 0.329 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.758907e-01 | 0.322 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.796090e-01 | 0.319 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.796090e-01 | 0.319 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.828368e-01 | 0.316 |
| R-HSA-1500620 | Meiosis | 4.833012e-01 | 0.316 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.833012e-01 | 0.316 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.833012e-01 | 0.316 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.833012e-01 | 0.316 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.869674e-01 | 0.313 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.869674e-01 | 0.313 |
| R-HSA-168249 | Innate Immune System | 4.887519e-01 | 0.311 |
| R-HSA-397014 | Muscle contraction | 4.901459e-01 | 0.310 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.906079e-01 | 0.309 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.942227e-01 | 0.306 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.942227e-01 | 0.306 |
| R-HSA-73884 | Base Excision Repair | 5.049153e-01 | 0.297 |
| R-HSA-202424 | Downstream TCR signaling | 5.049153e-01 | 0.297 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.119190e-01 | 0.291 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.153839e-01 | 0.288 |
| R-HSA-391251 | Protein folding | 5.153839e-01 | 0.288 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.153839e-01 | 0.288 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.188244e-01 | 0.285 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.188244e-01 | 0.285 |
| R-HSA-162906 | HIV Infection | 5.234621e-01 | 0.281 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.256315e-01 | 0.279 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.290013e-01 | 0.277 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.323460e-01 | 0.274 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.323460e-01 | 0.274 |
| R-HSA-1296071 | Potassium Channels | 5.323460e-01 | 0.274 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.323460e-01 | 0.274 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.385094e-01 | 0.269 |
| R-HSA-422356 | Regulation of insulin secretion | 5.389648e-01 | 0.268 |
| R-HSA-190236 | Signaling by FGFR | 5.389648e-01 | 0.268 |
| R-HSA-3214847 | HATs acetylate histones | 5.422394e-01 | 0.266 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.422394e-01 | 0.266 |
| R-HSA-8939211 | ESR-mediated signaling | 5.448587e-01 | 0.264 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.454908e-01 | 0.263 |
| R-HSA-68886 | M Phase | 5.456244e-01 | 0.263 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.487194e-01 | 0.261 |
| R-HSA-1483255 | PI Metabolism | 5.519252e-01 | 0.258 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.519252e-01 | 0.258 |
| R-HSA-74160 | Gene expression (Transcription) | 5.524973e-01 | 0.258 |
| R-HSA-111885 | Opioid Signalling | 5.582694e-01 | 0.253 |
| R-HSA-5663205 | Infectious disease | 5.592447e-01 | 0.252 |
| R-HSA-212436 | Generic Transcription Pathway | 5.631733e-01 | 0.249 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.645244e-01 | 0.248 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.645244e-01 | 0.248 |
| R-HSA-69239 | Synthesis of DNA | 5.706917e-01 | 0.244 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.706917e-01 | 0.244 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.706917e-01 | 0.244 |
| R-HSA-9609646 | HCMV Infection | 5.716729e-01 | 0.243 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.737428e-01 | 0.241 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.737428e-01 | 0.241 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.767724e-01 | 0.239 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.767724e-01 | 0.239 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.797806e-01 | 0.237 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.797806e-01 | 0.237 |
| R-HSA-9679506 | SARS-CoV Infections | 5.853349e-01 | 0.233 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.857337e-01 | 0.232 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.857337e-01 | 0.232 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.886788e-01 | 0.230 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.916031e-01 | 0.228 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.973383e-01 | 0.224 |
| R-HSA-416476 | G alpha (q) signalling events | 5.992648e-01 | 0.222 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.003571e-01 | 0.222 |
| R-HSA-373760 | L1CAM interactions | 6.030958e-01 | 0.220 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.059186e-01 | 0.218 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.059186e-01 | 0.218 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.100076e-01 | 0.215 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.115045e-01 | 0.214 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.170119e-01 | 0.210 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.181526e-01 | 0.209 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.224419e-01 | 0.206 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.251282e-01 | 0.204 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.330740e-01 | 0.199 |
| R-HSA-114608 | Platelet degranulation | 6.356853e-01 | 0.197 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.382782e-01 | 0.195 |
| R-HSA-1474165 | Reproduction | 6.459476e-01 | 0.190 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.509708e-01 | 0.186 |
| R-HSA-9909396 | Circadian clock | 6.509708e-01 | 0.186 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.509708e-01 | 0.186 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.534558e-01 | 0.185 |
| R-HSA-1643685 | Disease | 6.538337e-01 | 0.185 |
| R-HSA-163685 | Integration of energy metabolism | 6.632218e-01 | 0.178 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.680020e-01 | 0.175 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.796602e-01 | 0.168 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.798416e-01 | 0.168 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.842091e-01 | 0.165 |
| R-HSA-2187338 | Visual phototransduction | 6.909126e-01 | 0.161 |
| R-HSA-166520 | Signaling by NTRKs | 6.931155e-01 | 0.159 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.017730e-01 | 0.154 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.017730e-01 | 0.154 |
| R-HSA-69306 | DNA Replication | 7.038992e-01 | 0.152 |
| R-HSA-9609507 | Protein localization | 7.038992e-01 | 0.152 |
| R-HSA-73887 | Death Receptor Signaling | 7.060104e-01 | 0.151 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.081068e-01 | 0.150 |
| R-HSA-1989781 | PPARA activates gene expression | 7.081068e-01 | 0.150 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.122550e-01 | 0.147 |
| R-HSA-162587 | HIV Life Cycle | 7.122550e-01 | 0.147 |
| R-HSA-1474244 | Extracellular matrix organization | 7.129685e-01 | 0.147 |
| R-HSA-382551 | Transport of small molecules | 7.194498e-01 | 0.143 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.264196e-01 | 0.139 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.385571e-01 | 0.132 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.397013e-01 | 0.131 |
| R-HSA-418555 | G alpha (s) signalling events | 7.415594e-01 | 0.130 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.415594e-01 | 0.130 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.452361e-01 | 0.128 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.452361e-01 | 0.128 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.452361e-01 | 0.128 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.488610e-01 | 0.126 |
| R-HSA-73894 | DNA Repair | 7.532280e-01 | 0.123 |
| R-HSA-611105 | Respiratory electron transport | 7.542027e-01 | 0.123 |
| R-HSA-168255 | Influenza Infection | 7.559581e-01 | 0.122 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.571055e-01 | 0.121 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.679029e-01 | 0.115 |
| R-HSA-422475 | Axon guidance | 7.681407e-01 | 0.115 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.712079e-01 | 0.113 |
| R-HSA-983712 | Ion channel transport | 7.728429e-01 | 0.112 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 7.792679e-01 | 0.108 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.808458e-01 | 0.107 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.908427e-01 | 0.102 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.945529e-01 | 0.100 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.945529e-01 | 0.100 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 7.953136e-01 | 0.099 |
| R-HSA-72172 | mRNA Splicing | 7.974816e-01 | 0.098 |
| R-HSA-9675108 | Nervous system development | 8.042050e-01 | 0.095 |
| R-HSA-418594 | G alpha (i) signalling events | 8.092713e-01 | 0.092 |
| R-HSA-388396 | GPCR downstream signalling | 8.194635e-01 | 0.086 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.270890e-01 | 0.082 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.307787e-01 | 0.081 |
| R-HSA-72312 | rRNA processing | 8.343904e-01 | 0.079 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.402408e-01 | 0.076 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.513339e-01 | 0.070 |
| R-HSA-2262752 | Cellular responses to stress | 8.656478e-01 | 0.063 |
| R-HSA-372790 | Signaling by GPCR | 8.741465e-01 | 0.058 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.819500e-01 | 0.055 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.836410e-01 | 0.054 |
| R-HSA-9658195 | Leishmania infection | 8.836410e-01 | 0.054 |
| R-HSA-1483257 | Phospholipid metabolism | 8.948239e-01 | 0.048 |
| R-HSA-8957322 | Metabolism of steroids | 9.147111e-01 | 0.039 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.245855e-01 | 0.034 |
| R-HSA-109582 | Hemostasis | 9.282169e-01 | 0.032 |
| R-HSA-500792 | GPCR ligand binding | 9.327756e-01 | 0.030 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.361640e-01 | 0.029 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.501275e-01 | 0.022 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.673077e-01 | 0.014 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.901073e-01 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 9.953289e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.989987e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999964e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.829 | 0.162 | 2 | 0.777 |
GRK1 |
0.823 | 0.265 | -2 | 0.761 |
CDC7 |
0.821 | 0.149 | 1 | 0.825 |
CAMK2G |
0.818 | 0.208 | 2 | 0.827 |
MOS |
0.817 | 0.194 | 1 | 0.821 |
CLK3 |
0.817 | 0.164 | 1 | 0.751 |
NDR2 |
0.814 | 0.142 | -3 | 0.784 |
PIM3 |
0.811 | 0.087 | -3 | 0.789 |
IKKB |
0.811 | 0.003 | -2 | 0.754 |
GCN2 |
0.809 | -0.030 | 2 | 0.746 |
PRPK |
0.809 | -0.006 | -1 | 0.838 |
ATR |
0.808 | 0.082 | 1 | 0.799 |
MARK4 |
0.808 | 0.086 | 4 | 0.872 |
HIPK4 |
0.808 | 0.130 | 1 | 0.759 |
CAMK2B |
0.807 | 0.207 | 2 | 0.815 |
GRK6 |
0.807 | 0.119 | 1 | 0.792 |
CAMK2A |
0.807 | 0.234 | 2 | 0.847 |
GRK5 |
0.806 | 0.059 | -3 | 0.810 |
FAM20C |
0.806 | 0.079 | 2 | 0.533 |
DSTYK |
0.806 | 0.013 | 2 | 0.783 |
SRPK1 |
0.806 | 0.098 | -3 | 0.731 |
ATM |
0.805 | 0.133 | 1 | 0.783 |
SKMLCK |
0.805 | 0.105 | -2 | 0.813 |
GRK7 |
0.804 | 0.184 | 1 | 0.738 |
MTOR |
0.804 | -0.075 | 1 | 0.705 |
RSK2 |
0.804 | 0.059 | -3 | 0.750 |
NEK6 |
0.804 | 0.061 | -2 | 0.912 |
BMPR2 |
0.804 | 0.080 | -2 | 0.886 |
CAMK1B |
0.803 | -0.003 | -3 | 0.831 |
BMPR1B |
0.802 | 0.156 | 1 | 0.772 |
IKKA |
0.802 | 0.063 | -2 | 0.757 |
NUAK2 |
0.802 | 0.029 | -3 | 0.805 |
PDHK4 |
0.801 | -0.146 | 1 | 0.766 |
LATS2 |
0.801 | 0.113 | -5 | 0.701 |
TGFBR2 |
0.801 | 0.050 | -2 | 0.843 |
CAMK2D |
0.801 | 0.123 | -3 | 0.816 |
MLK1 |
0.801 | -0.014 | 2 | 0.713 |
TBK1 |
0.801 | -0.067 | 1 | 0.621 |
ULK2 |
0.801 | -0.092 | 2 | 0.698 |
RAF1 |
0.800 | -0.115 | 1 | 0.752 |
AMPKA1 |
0.800 | 0.046 | -3 | 0.815 |
CDKL1 |
0.799 | 0.031 | -3 | 0.774 |
NEK7 |
0.799 | -0.041 | -3 | 0.785 |
IKKE |
0.799 | -0.065 | 1 | 0.609 |
KIS |
0.799 | 0.035 | 1 | 0.578 |
PIM1 |
0.798 | 0.073 | -3 | 0.754 |
GRK4 |
0.798 | 0.033 | -2 | 0.846 |
SRPK2 |
0.798 | 0.095 | -3 | 0.661 |
HUNK |
0.797 | -0.059 | 2 | 0.698 |
ACVR2A |
0.797 | 0.156 | -2 | 0.851 |
P90RSK |
0.797 | 0.037 | -3 | 0.748 |
NDR1 |
0.796 | -0.003 | -3 | 0.791 |
NLK |
0.796 | -0.057 | 1 | 0.729 |
ACVR2B |
0.796 | 0.164 | -2 | 0.856 |
MAPKAPK2 |
0.796 | 0.062 | -3 | 0.702 |
AMPKA2 |
0.796 | 0.053 | -3 | 0.785 |
PDHK1 |
0.796 | -0.128 | 1 | 0.731 |
QSK |
0.796 | 0.079 | 4 | 0.850 |
BRSK1 |
0.796 | 0.075 | -3 | 0.761 |
MLK3 |
0.795 | 0.050 | 2 | 0.669 |
PLK1 |
0.795 | 0.095 | -2 | 0.883 |
RIPK3 |
0.795 | -0.040 | 3 | 0.654 |
PKN3 |
0.795 | -0.024 | -3 | 0.784 |
CHAK2 |
0.794 | -0.026 | -1 | 0.789 |
TGFBR1 |
0.794 | 0.084 | -2 | 0.788 |
NIK |
0.793 | -0.065 | -3 | 0.840 |
MARK3 |
0.793 | 0.078 | 4 | 0.830 |
DAPK2 |
0.793 | 0.001 | -3 | 0.835 |
WNK1 |
0.793 | -0.041 | -2 | 0.826 |
SRPK3 |
0.792 | 0.067 | -3 | 0.702 |
CAMLCK |
0.792 | -0.016 | -2 | 0.799 |
DNAPK |
0.792 | 0.157 | 1 | 0.681 |
LATS1 |
0.792 | 0.124 | -3 | 0.794 |
PKCD |
0.791 | 0.008 | 2 | 0.723 |
TSSK2 |
0.791 | -0.008 | -5 | 0.806 |
MARK2 |
0.791 | 0.070 | 4 | 0.809 |
DYRK2 |
0.791 | 0.059 | 1 | 0.651 |
ALK2 |
0.791 | 0.133 | -2 | 0.795 |
RSK3 |
0.791 | 0.001 | -3 | 0.738 |
MAPKAPK3 |
0.790 | -0.016 | -3 | 0.748 |
PLK3 |
0.790 | 0.070 | 2 | 0.711 |
PRKD1 |
0.790 | -0.012 | -3 | 0.778 |
MST4 |
0.790 | -0.058 | 2 | 0.751 |
ULK1 |
0.790 | -0.119 | -3 | 0.757 |
RSK4 |
0.790 | 0.074 | -3 | 0.704 |
SIK |
0.789 | 0.049 | -3 | 0.741 |
BCKDK |
0.789 | -0.083 | -1 | 0.768 |
ALK4 |
0.789 | 0.031 | -2 | 0.812 |
TSSK1 |
0.789 | 0.009 | -3 | 0.829 |
TTBK2 |
0.789 | -0.098 | 2 | 0.621 |
MASTL |
0.788 | -0.154 | -2 | 0.823 |
CDKL5 |
0.788 | -0.007 | -3 | 0.769 |
DLK |
0.788 | -0.064 | 1 | 0.758 |
NIM1 |
0.787 | -0.055 | 3 | 0.700 |
BMPR1A |
0.787 | 0.131 | 1 | 0.775 |
CK2A2 |
0.787 | 0.151 | 1 | 0.653 |
PKACG |
0.787 | -0.016 | -2 | 0.681 |
PKN2 |
0.787 | -0.071 | -3 | 0.807 |
MSK2 |
0.787 | 0.014 | -3 | 0.722 |
PRKD2 |
0.787 | -0.013 | -3 | 0.744 |
P70S6KB |
0.787 | -0.020 | -3 | 0.775 |
NEK9 |
0.787 | -0.086 | 2 | 0.739 |
ICK |
0.787 | 0.012 | -3 | 0.800 |
ERK5 |
0.786 | -0.085 | 1 | 0.627 |
SMG1 |
0.786 | 0.053 | 1 | 0.766 |
BRSK2 |
0.786 | 0.024 | -3 | 0.793 |
QIK |
0.786 | -0.036 | -3 | 0.811 |
WNK3 |
0.786 | -0.165 | 1 | 0.737 |
MARK1 |
0.786 | 0.043 | 4 | 0.838 |
ANKRD3 |
0.785 | -0.071 | 1 | 0.766 |
MLK2 |
0.785 | -0.042 | 2 | 0.728 |
NUAK1 |
0.785 | 0.005 | -3 | 0.757 |
TLK2 |
0.785 | 0.060 | 1 | 0.759 |
PRKX |
0.785 | 0.092 | -3 | 0.660 |
CDK8 |
0.785 | -0.020 | 1 | 0.576 |
MLK4 |
0.785 | -0.004 | 2 | 0.644 |
CLK2 |
0.785 | 0.083 | -3 | 0.723 |
HIPK2 |
0.784 | 0.077 | 1 | 0.568 |
MSK1 |
0.784 | 0.048 | -3 | 0.726 |
IRE1 |
0.783 | -0.054 | 1 | 0.766 |
PKR |
0.783 | 0.021 | 1 | 0.789 |
CDK1 |
0.783 | 0.018 | 1 | 0.556 |
RIPK1 |
0.782 | -0.107 | 1 | 0.784 |
AURC |
0.782 | 0.012 | -2 | 0.580 |
PRP4 |
0.782 | 0.099 | -3 | 0.801 |
PKCB |
0.781 | -0.011 | 2 | 0.664 |
PAK1 |
0.781 | -0.035 | -2 | 0.709 |
PKACB |
0.780 | 0.040 | -2 | 0.606 |
MEK1 |
0.780 | -0.090 | 2 | 0.761 |
MELK |
0.780 | -0.033 | -3 | 0.778 |
YSK4 |
0.779 | -0.066 | 1 | 0.676 |
GRK2 |
0.779 | -0.007 | -2 | 0.718 |
HIPK1 |
0.778 | 0.052 | 1 | 0.661 |
CK2A1 |
0.778 | 0.130 | 1 | 0.630 |
CAMK4 |
0.778 | -0.105 | -3 | 0.790 |
CLK4 |
0.778 | 0.010 | -3 | 0.748 |
JNK3 |
0.778 | 0.021 | 1 | 0.559 |
GSK3A |
0.778 | 0.107 | 4 | 0.531 |
VRK2 |
0.778 | -0.068 | 1 | 0.803 |
PKCA |
0.778 | -0.014 | 2 | 0.654 |
PKCG |
0.777 | -0.045 | 2 | 0.660 |
CDK19 |
0.777 | -0.029 | 1 | 0.539 |
IRE2 |
0.777 | -0.047 | 2 | 0.659 |
DYRK4 |
0.777 | 0.052 | 1 | 0.560 |
CAMK1G |
0.776 | -0.020 | -3 | 0.746 |
PERK |
0.776 | -0.006 | -2 | 0.883 |
MYLK4 |
0.775 | -0.028 | -2 | 0.708 |
PASK |
0.775 | 0.085 | -3 | 0.802 |
PAK3 |
0.775 | -0.080 | -2 | 0.708 |
PKCZ |
0.775 | -0.035 | 2 | 0.683 |
CDK18 |
0.775 | 0.016 | 1 | 0.519 |
CK1E |
0.775 | 0.010 | -3 | 0.548 |
MNK1 |
0.775 | -0.023 | -2 | 0.744 |
CDK5 |
0.775 | -0.001 | 1 | 0.601 |
PKCH |
0.774 | -0.056 | 2 | 0.645 |
SSTK |
0.774 | 0.014 | 4 | 0.836 |
JNK2 |
0.774 | 0.018 | 1 | 0.517 |
MNK2 |
0.774 | -0.034 | -2 | 0.733 |
MEKK3 |
0.774 | -0.051 | 1 | 0.714 |
CDK7 |
0.774 | -0.028 | 1 | 0.578 |
DRAK1 |
0.773 | -0.072 | 1 | 0.731 |
CDK13 |
0.772 | -0.034 | 1 | 0.557 |
BRAF |
0.772 | -0.004 | -4 | 0.668 |
MAPKAPK5 |
0.772 | -0.071 | -3 | 0.709 |
PKG2 |
0.771 | -0.023 | -2 | 0.601 |
CLK1 |
0.771 | -0.005 | -3 | 0.729 |
SGK3 |
0.771 | -0.016 | -3 | 0.741 |
DCAMKL1 |
0.771 | -0.012 | -3 | 0.753 |
GRK3 |
0.771 | 0.010 | -2 | 0.671 |
AURB |
0.771 | -0.032 | -2 | 0.583 |
DYRK1A |
0.771 | 0.014 | 1 | 0.651 |
CHAK1 |
0.771 | -0.136 | 2 | 0.655 |
TLK1 |
0.771 | -0.009 | -2 | 0.871 |
PLK4 |
0.770 | -0.051 | 2 | 0.553 |
PAK2 |
0.770 | -0.087 | -2 | 0.697 |
NEK2 |
0.770 | -0.130 | 2 | 0.708 |
PHKG1 |
0.770 | -0.084 | -3 | 0.797 |
CK1D |
0.770 | 0.025 | -3 | 0.505 |
GSK3B |
0.770 | 0.051 | 4 | 0.522 |
CDK17 |
0.770 | -0.001 | 1 | 0.479 |
CDK3 |
0.770 | 0.015 | 1 | 0.491 |
P38B |
0.769 | 0.015 | 1 | 0.496 |
PRKD3 |
0.769 | -0.059 | -3 | 0.722 |
DYRK1B |
0.769 | 0.017 | 1 | 0.593 |
AKT2 |
0.769 | -0.005 | -3 | 0.681 |
P38G |
0.769 | -0.002 | 1 | 0.463 |
PAK6 |
0.769 | -0.044 | -2 | 0.629 |
HRI |
0.769 | -0.071 | -2 | 0.899 |
MEKK1 |
0.768 | -0.083 | 1 | 0.719 |
MEKK2 |
0.768 | -0.035 | 2 | 0.719 |
AURA |
0.768 | -0.031 | -2 | 0.563 |
CHK1 |
0.768 | -0.068 | -3 | 0.771 |
CDK2 |
0.768 | -0.065 | 1 | 0.636 |
PIM2 |
0.768 | -0.009 | -3 | 0.730 |
SNRK |
0.768 | -0.157 | 2 | 0.577 |
DYRK3 |
0.767 | 0.031 | 1 | 0.682 |
P38A |
0.767 | -0.022 | 1 | 0.569 |
MEK5 |
0.767 | -0.166 | 2 | 0.729 |
PLK2 |
0.767 | 0.049 | -3 | 0.693 |
TAO3 |
0.766 | -0.018 | 1 | 0.705 |
CK1A2 |
0.766 | 0.015 | -3 | 0.507 |
NEK5 |
0.766 | -0.047 | 1 | 0.754 |
CDK12 |
0.766 | -0.033 | 1 | 0.531 |
ERK1 |
0.766 | -0.017 | 1 | 0.492 |
HIPK3 |
0.766 | 0.002 | 1 | 0.628 |
CK1G1 |
0.765 | -0.017 | -3 | 0.535 |
ZAK |
0.765 | -0.115 | 1 | 0.697 |
P38D |
0.765 | 0.017 | 1 | 0.480 |
WNK4 |
0.763 | -0.115 | -2 | 0.824 |
PKACA |
0.763 | 0.005 | -2 | 0.552 |
CAMK1D |
0.763 | -0.003 | -3 | 0.674 |
TTBK1 |
0.762 | -0.127 | 2 | 0.548 |
SMMLCK |
0.762 | -0.044 | -3 | 0.794 |
MST3 |
0.762 | -0.077 | 2 | 0.715 |
IRAK4 |
0.762 | -0.081 | 1 | 0.758 |
CDK9 |
0.762 | -0.061 | 1 | 0.563 |
ERK2 |
0.761 | -0.055 | 1 | 0.564 |
DAPK3 |
0.761 | 0.019 | -3 | 0.774 |
CDK16 |
0.761 | 0.005 | 1 | 0.498 |
CDK14 |
0.761 | -0.021 | 1 | 0.563 |
PINK1 |
0.761 | -0.165 | 1 | 0.757 |
DCAMKL2 |
0.760 | -0.059 | -3 | 0.779 |
JNK1 |
0.760 | 0.011 | 1 | 0.524 |
PKCT |
0.760 | -0.063 | 2 | 0.658 |
NEK8 |
0.760 | -0.095 | 2 | 0.704 |
MPSK1 |
0.759 | -0.003 | 1 | 0.709 |
PDK1 |
0.758 | -0.047 | 1 | 0.723 |
GAK |
0.757 | -0.043 | 1 | 0.738 |
P70S6K |
0.757 | -0.050 | -3 | 0.700 |
AKT1 |
0.757 | -0.019 | -3 | 0.697 |
DAPK1 |
0.755 | -0.007 | -3 | 0.765 |
PKCE |
0.754 | -0.033 | 2 | 0.639 |
EEF2K |
0.754 | -0.049 | 3 | 0.703 |
PHKG2 |
0.754 | -0.115 | -3 | 0.781 |
GCK |
0.754 | -0.029 | 1 | 0.687 |
TAO2 |
0.754 | -0.106 | 2 | 0.759 |
VRK1 |
0.754 | -0.036 | 2 | 0.725 |
CDK10 |
0.753 | -0.028 | 1 | 0.553 |
CAMKK1 |
0.753 | -0.131 | -2 | 0.727 |
MST2 |
0.753 | -0.083 | 1 | 0.699 |
TAK1 |
0.752 | -0.065 | 1 | 0.733 |
LKB1 |
0.752 | -0.058 | -3 | 0.808 |
ERK7 |
0.752 | -0.043 | 2 | 0.460 |
CAMKK2 |
0.752 | -0.112 | -2 | 0.728 |
PKCI |
0.752 | -0.095 | 2 | 0.653 |
NEK11 |
0.751 | -0.177 | 1 | 0.694 |
SGK1 |
0.751 | 0.014 | -3 | 0.604 |
STK33 |
0.750 | -0.097 | 2 | 0.544 |
PAK5 |
0.750 | -0.076 | -2 | 0.570 |
TTK |
0.749 | 0.134 | -2 | 0.898 |
LRRK2 |
0.749 | -0.100 | 2 | 0.736 |
PAK4 |
0.749 | -0.061 | -2 | 0.578 |
TNIK |
0.749 | -0.051 | 3 | 0.724 |
MAK |
0.747 | 0.056 | -2 | 0.690 |
IRAK1 |
0.746 | -0.244 | -1 | 0.736 |
MINK |
0.746 | -0.103 | 1 | 0.673 |
MAP3K15 |
0.746 | -0.107 | 1 | 0.676 |
CAMK1A |
0.746 | -0.022 | -3 | 0.641 |
ROCK2 |
0.745 | 0.000 | -3 | 0.759 |
HGK |
0.745 | -0.104 | 3 | 0.709 |
PDHK3_TYR |
0.745 | 0.236 | 4 | 0.868 |
AKT3 |
0.745 | -0.009 | -3 | 0.619 |
MOK |
0.744 | 0.028 | 1 | 0.675 |
SLK |
0.744 | -0.068 | -2 | 0.726 |
NEK4 |
0.744 | -0.173 | 1 | 0.697 |
NEK1 |
0.744 | -0.103 | 1 | 0.725 |
HPK1 |
0.742 | -0.106 | 1 | 0.668 |
ALPHAK3 |
0.741 | 0.059 | -1 | 0.758 |
MRCKA |
0.741 | -0.035 | -3 | 0.737 |
PKN1 |
0.741 | -0.083 | -3 | 0.722 |
LOK |
0.740 | -0.115 | -2 | 0.759 |
YANK3 |
0.740 | -0.031 | 2 | 0.358 |
KHS1 |
0.740 | -0.061 | 1 | 0.661 |
CDK6 |
0.740 | -0.059 | 1 | 0.537 |
MST1 |
0.740 | -0.141 | 1 | 0.680 |
CK1A |
0.740 | 0.003 | -3 | 0.418 |
BUB1 |
0.739 | 0.009 | -5 | 0.738 |
MEK2 |
0.739 | -0.181 | 2 | 0.729 |
PDHK4_TYR |
0.739 | 0.168 | 2 | 0.790 |
CDK4 |
0.739 | -0.051 | 1 | 0.525 |
MEKK6 |
0.739 | -0.200 | 1 | 0.676 |
MRCKB |
0.739 | -0.043 | -3 | 0.725 |
KHS2 |
0.739 | -0.057 | 1 | 0.674 |
CHK2 |
0.737 | -0.058 | -3 | 0.635 |
MAP2K6_TYR |
0.737 | 0.136 | -1 | 0.859 |
DMPK1 |
0.737 | 0.017 | -3 | 0.742 |
HASPIN |
0.737 | 0.005 | -1 | 0.666 |
OSR1 |
0.736 | -0.063 | 2 | 0.711 |
RIPK2 |
0.735 | -0.239 | 1 | 0.653 |
SBK |
0.735 | -0.013 | -3 | 0.575 |
PDHK1_TYR |
0.734 | 0.092 | -1 | 0.874 |
YSK1 |
0.734 | -0.143 | 2 | 0.708 |
MAP2K4_TYR |
0.734 | 0.058 | -1 | 0.862 |
BMPR2_TYR |
0.734 | 0.060 | -1 | 0.868 |
PBK |
0.733 | -0.078 | 1 | 0.630 |
TESK1_TYR |
0.732 | -0.005 | 3 | 0.761 |
EPHA6 |
0.731 | 0.118 | -1 | 0.869 |
MAP2K7_TYR |
0.730 | -0.036 | 2 | 0.766 |
ROCK1 |
0.730 | -0.027 | -3 | 0.737 |
ASK1 |
0.727 | -0.095 | 1 | 0.672 |
MYO3B |
0.727 | -0.069 | 2 | 0.716 |
PKMYT1_TYR |
0.727 | -0.066 | 3 | 0.731 |
PKG1 |
0.727 | -0.072 | -2 | 0.504 |
CK1G3 |
0.726 | 0.027 | -3 | 0.373 |
PINK1_TYR |
0.726 | -0.132 | 1 | 0.773 |
CRIK |
0.726 | -0.015 | -3 | 0.686 |
EPHB4 |
0.725 | 0.068 | -1 | 0.850 |
MYO3A |
0.724 | -0.100 | 1 | 0.719 |
BIKE |
0.723 | -0.040 | 1 | 0.615 |
NEK3 |
0.723 | -0.212 | 1 | 0.660 |
EPHA4 |
0.722 | 0.080 | 2 | 0.696 |
TAO1 |
0.722 | -0.119 | 1 | 0.636 |
TXK |
0.722 | 0.096 | 1 | 0.732 |
LIMK2_TYR |
0.721 | -0.058 | -3 | 0.845 |
SRMS |
0.717 | 0.054 | 1 | 0.772 |
STLK3 |
0.717 | -0.136 | 1 | 0.665 |
MST1R |
0.716 | -0.080 | 3 | 0.704 |
YES1 |
0.716 | -0.023 | -1 | 0.857 |
RET |
0.716 | -0.110 | 1 | 0.722 |
LIMK1_TYR |
0.716 | -0.156 | 2 | 0.754 |
EPHB2 |
0.716 | 0.054 | -1 | 0.834 |
BLK |
0.715 | 0.065 | -1 | 0.866 |
EPHB1 |
0.715 | 0.025 | 1 | 0.757 |
TYK2 |
0.715 | -0.147 | 1 | 0.709 |
FER |
0.714 | -0.039 | 1 | 0.782 |
JAK3 |
0.713 | -0.038 | 1 | 0.719 |
INSRR |
0.713 | -0.027 | 3 | 0.645 |
CSF1R |
0.713 | -0.052 | 3 | 0.673 |
DDR1 |
0.713 | -0.114 | 4 | 0.798 |
HCK |
0.713 | -0.026 | -1 | 0.858 |
JAK2 |
0.712 | -0.119 | 1 | 0.691 |
LCK |
0.712 | 0.019 | -1 | 0.858 |
EPHB3 |
0.712 | 0.009 | -1 | 0.837 |
ABL2 |
0.712 | -0.046 | -1 | 0.790 |
EPHA7 |
0.712 | 0.056 | 2 | 0.691 |
ROS1 |
0.711 | -0.115 | 3 | 0.650 |
TYRO3 |
0.711 | -0.111 | 3 | 0.666 |
FGR |
0.711 | -0.083 | 1 | 0.721 |
TNK2 |
0.710 | -0.012 | 3 | 0.676 |
KDR |
0.710 | -0.028 | 3 | 0.662 |
FLT1 |
0.710 | 0.007 | -1 | 0.830 |
YANK2 |
0.710 | -0.044 | 2 | 0.382 |
FYN |
0.709 | 0.035 | -1 | 0.852 |
FGFR2 |
0.708 | -0.065 | 3 | 0.699 |
ITK |
0.708 | -0.047 | -1 | 0.820 |
KIT |
0.707 | -0.069 | 3 | 0.678 |
CK1G2 |
0.707 | 0.010 | -3 | 0.459 |
EPHA5 |
0.707 | 0.065 | 2 | 0.684 |
EPHA3 |
0.706 | -0.014 | 2 | 0.674 |
ABL1 |
0.706 | -0.085 | -1 | 0.781 |
MET |
0.705 | -0.037 | 3 | 0.682 |
TEC |
0.704 | -0.030 | -1 | 0.761 |
NEK10_TYR |
0.704 | -0.104 | 1 | 0.603 |
MERTK |
0.704 | -0.042 | 3 | 0.678 |
JAK1 |
0.704 | -0.066 | 1 | 0.647 |
AAK1 |
0.703 | -0.019 | 1 | 0.506 |
BMX |
0.703 | -0.028 | -1 | 0.738 |
PDGFRB |
0.703 | -0.139 | 3 | 0.690 |
WEE1_TYR |
0.703 | -0.066 | -1 | 0.732 |
SYK |
0.702 | 0.068 | -1 | 0.800 |
FLT3 |
0.702 | -0.136 | 3 | 0.670 |
FGFR3 |
0.702 | -0.052 | 3 | 0.679 |
TEK |
0.701 | -0.106 | 3 | 0.625 |
PTK6 |
0.701 | -0.110 | -1 | 0.721 |
EPHA1 |
0.701 | -0.020 | 3 | 0.667 |
EPHA8 |
0.701 | 0.006 | -1 | 0.828 |
PTK2 |
0.701 | 0.042 | -1 | 0.824 |
BTK |
0.701 | -0.121 | -1 | 0.781 |
FGFR1 |
0.701 | -0.104 | 3 | 0.663 |
FRK |
0.701 | -0.042 | -1 | 0.858 |
ERBB2 |
0.699 | -0.100 | 1 | 0.699 |
TNK1 |
0.699 | -0.106 | 3 | 0.655 |
EGFR |
0.699 | -0.016 | 1 | 0.622 |
NTRK1 |
0.698 | -0.117 | -1 | 0.800 |
DDR2 |
0.698 | -0.007 | 3 | 0.635 |
PDGFRA |
0.697 | -0.179 | 3 | 0.683 |
ALK |
0.697 | -0.113 | 3 | 0.610 |
LTK |
0.697 | -0.101 | 3 | 0.634 |
SRC |
0.697 | -0.043 | -1 | 0.837 |
AXL |
0.696 | -0.122 | 3 | 0.675 |
LYN |
0.696 | -0.069 | 3 | 0.596 |
TNNI3K_TYR |
0.696 | -0.118 | 1 | 0.699 |
PTK2B |
0.694 | -0.041 | -1 | 0.773 |
FGFR4 |
0.694 | -0.043 | -1 | 0.761 |
NTRK2 |
0.693 | -0.134 | 3 | 0.663 |
FLT4 |
0.693 | -0.137 | 3 | 0.647 |
EPHA2 |
0.692 | 0.013 | -1 | 0.795 |
NTRK3 |
0.692 | -0.098 | -1 | 0.747 |
INSR |
0.690 | -0.141 | 3 | 0.616 |
ERBB4 |
0.689 | -0.001 | 1 | 0.647 |
CSK |
0.686 | -0.121 | 2 | 0.693 |
MATK |
0.684 | -0.133 | -1 | 0.694 |
IGF1R |
0.679 | -0.125 | 3 | 0.564 |
ZAP70 |
0.676 | -0.003 | -1 | 0.696 |
MUSK |
0.674 | -0.153 | 1 | 0.610 |
FES |
0.673 | -0.088 | -1 | 0.706 |