Motif 955 (n=133)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
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A1X283 | SH3PXD2B | S675 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
E7EW31 | PROB1 | S74 | ochoa | Proline-rich basic protein 1 | None |
O00330 | PDHX | S196 | ochoa | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
O00571 | DDX3X | S23 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
O14686 | KMT2D | S3468 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14828 | SCAMP3 | S32 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
O43294 | TGFB1I1 | S164 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
O43318 | MAP3K7 | S363 | ochoa | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
O43491 | EPB41L2 | S550 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
O43663 | PRC1 | S501 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
O43900 | PRICKLE3 | S475 | ochoa | Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. |
O75460 | ERN1 | S729 | psp | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:21317875, PubMed:24508390). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:21317875, PubMed:24508390). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:19328063, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:30118681, ECO:0000269|PubMed:36739529, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}. |
O75533 | SF3B1 | S194 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
O75563 | SKAP2 | S90 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
O75676 | RPS6KA4 | S737 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
O75914 | PAK3 | S220 | ochoa | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
O95104 | SCAF4 | S139 | ochoa | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
O96017 | CHEK2 | S518 | ochoa | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
P00519 | ABL1 | S75 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
P03372 | ESR1 | S212 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
P04629 | NTRK1 | S677 | ochoa | High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA) | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}. |
P04899 | GNAI2 | S144 | psp | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
P08138 | NGFR | S277 | psp | Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}. |
P08913 | ADRA2A | S247 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
P10909 | CLU | S396 | ochoa|psp | Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)] | [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17407782, PubMed:17412999). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex (PubMed:2780565, PubMed:1903064, PubMed:2601725, PubMed:2721499, PubMed:1551440, PubMed:9200695, PubMed:34667172). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). {ECO:0000250|UniProtKB:P05371, ECO:0000250|UniProtKB:Q06890, ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:1903064, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2601725, ECO:0000269|PubMed:2721499, ECO:0000269|PubMed:2780565, ECO:0000269|PubMed:34667172, ECO:0000269|PubMed:9200695}.; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. {ECO:0000269|PubMed:24073260}.; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405). {ECO:0000269|PubMed:21567405, ECO:0000269|PubMed:24073260}. |
P15056 | BRAF | S614 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
P16989 | YBX3 | S324 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
P18084 | ITGB5 | S759 | ochoa|psp | Integrin beta-5 | Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. |
P22090 | RPS4Y1 | S204 | ochoa | Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) | None |
P25705 | ATP5F1A | S166 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
P27816 | MAP4 | S764 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
P32418 | SLC8A1 | S392 | ochoa | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:11241183, PubMed:1374913, PubMed:1476165). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11241183, PubMed:1374913, PubMed:1476165). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:11241183, PubMed:1374913, PubMed:1476165). Required for normal embryonic heart development and the onset of heart contractions (By similarity). {ECO:0000250|UniProtKB:P70414, ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}. |
P34820 | BMP8B | S243 | ochoa | Bone morphogenetic protein 8B (BMP-8) (BMP-8B) (Osteogenic protein 2) (OP-2) | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). {ECO:0000250}. |
P35573 | AGL | S582 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
P42684 | ABL2 | S121 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
P50991 | CCT4 | S36 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
P51788 | CLCN2 | S865 | ochoa | Chloride channel protein 2 (ClC-2) | Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity (PubMed:16155254, PubMed:17567819, PubMed:19191339, PubMed:23632988, PubMed:29403011, PubMed:29403012, PubMed:36964785, PubMed:38345841). Contributes to chloride conductance involved in neuron excitability. In hippocampal neurons, generates a significant part of resting membrane conductance and provides an additional chloride efflux pathway to prevent chloride accumulation in dendrites upon GABA receptor activation. In glia, associates with the auxiliary subunit HEPACAM/GlialCAM at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux buffering extracellular chloride and potassium concentrations (PubMed:19191339, PubMed:22405205, PubMed:23707145). Regulates aldosterone production in adrenal glands. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated calcium channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). Contributes to chloride conductance in retinal pigment epithelium involved in phagocytosis of shed photoreceptor outer segments and photoreceptor renewal (PubMed:36964785). Conducts chloride currents at the basolateral membrane of epithelial cells with a role in chloride reabsorption rather than secretion (By similarity) (PubMed:16155254). Permeable to small monovalent anions with chloride > thiocyanate > bromide > nitrate > iodide ion selectivity (By similarity) (PubMed:29403012). {ECO:0000250|UniProtKB:P35525, ECO:0000250|UniProtKB:Q9R0A1, ECO:0000269|PubMed:16155254, ECO:0000269|PubMed:17567819, ECO:0000269|PubMed:19191339, ECO:0000269|PubMed:22405205, ECO:0000269|PubMed:23632988, ECO:0000269|PubMed:23707145, ECO:0000269|PubMed:29403011, ECO:0000269|PubMed:29403012, ECO:0000269|PubMed:36964785, ECO:0000269|PubMed:38345841}. |
P52735 | VAV2 | S639 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
P53778 | MAPK12 | S180 | ochoa | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}. |
P62701 | RPS4X | S204 | ochoa | Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
P78527 | PRKDC | S2056 | psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
P85299 | PRR5 | S240 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
Q00G26 | PLIN5 | S322 | ochoa | Perilipin-5 (Lipid storage droplet protein 5) | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250, ECO:0000269|PubMed:17234449}. |
Q01196 | RUNX1 | S50 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
Q02156 | PRKCE | S316 | psp | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
Q03111 | MLLT1 | S440 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
Q08043 | ACTN3 | S321 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
Q08211 | DHX9 | S321 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
Q08379 | GOLGA2 | S774 | ochoa | Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) | Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}. |
Q09666 | AHNAK | S3509 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q12834 | CDC20 | S161 | psp | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
Q13148 | TARDBP | S48 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
Q13164 | MAPK7 | S567 | psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
Q14004 | CDK13 | S864 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
Q14186 | TFDP1 | S30 | ochoa | Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:7739537, PubMed:8405995). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537, ECO:0000269|PubMed:8405995}. |
Q14493 | SLBP | S182 | ochoa | Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) | RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}. |
Q14676 | MDC1 | S763 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q14697 | GANAB | S868 | ochoa | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
Q15345 | LRRC41 | S326 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
Q15743 | GPR68 | S328 | ochoa | G-protein coupled receptor 68 (G-protein coupled receptor 12A) (GPR12A) (Ovarian cancer G-protein coupled receptor 1) (OGR-1) | Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:29677517, PubMed:39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:29677517, PubMed:39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517, PubMed:30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q8BFQ3, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:29677517, ECO:0000269|PubMed:30471999, ECO:0000269|PubMed:32865988, ECO:0000269|PubMed:33478938, ECO:0000269|PubMed:39753132}. |
Q15772 | SPEG | S2566 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q16658 | FSCN1 | S218 | ochoa | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
Q2TAC6 | KIF19 | S895 | ochoa | Kinesin-like protein KIF19 | Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. {ECO:0000250}. |
Q3L8U1 | CHD9 | S2286 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
Q5T8R8 | DOCK8-AS1 | S48 | ochoa | Uncharacterized protein DOCK8-AS1 (DOCK8 antisense RNA 1) | None |
Q5VWQ8 | DAB2IP | S895 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
Q641Q2 | WASHC2A | S1054 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q6N022 | TENM4 | S2585 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
Q6PGN9 | PSRC1 | S223 | psp | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
Q6T4R5 | NHS | S388 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
Q6UB98 | ANKRD12 | S526 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
Q6ZV73 | FGD6 | S554 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
Q76I76 | SSH2 | S487 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
Q7Z4W1 | DCXR | S38 | ochoa | L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H) | Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. |
Q7Z5Y6 | BMP8A | S243 | ochoa | Bone morphogenetic protein 8A (BMP-8A) | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. {ECO:0000250, ECO:0000269|PubMed:22579288}.; FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:22579288, PubMed:31940275). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:31940275). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed:31940275). {ECO:0000269|PubMed:22579288, ECO:0000269|PubMed:31940275}. |
Q8IUW5 | RELL1 | S244 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
Q8IVF2 | AHNAK2 | S765 | ochoa | Protein AHNAK2 | None |
Q8IVT5 | KSR1 | S409 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
Q8IWB6 | TEX14 | S437 | psp | Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein) | Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). {ECO:0000250}. |
Q8N3J3 | HROB | S47 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
Q8N6F7 | GCSAM | S99 | ochoa | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
Q8NEV4 | MYO3A | S177 | psp | Myosin-IIIa (EC 2.7.11.1) | Actin-dependent motor protein with a protein kinase activity, playing an essential role in hearing (PubMed:12032315, PubMed:29880844, PubMed:34788109). Probably also plays a role in vision. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:29880844, PubMed:34788109). {ECO:0000250|UniProtKB:Q8K3H5, ECO:0000269|PubMed:12032315, ECO:0000269|PubMed:29880844, ECO:0000269|PubMed:34788109}. |
Q8TAF3 | WDR48 | S335 | ochoa | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:27650958, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}. |
Q8TAP9 | MPLKIP | S124 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
Q8TC07 | TBC1D15 | S267 | ochoa | TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) | Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}. |
Q8TER5 | ARHGEF40 | S1421 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
Q8WWL2 | SPIRE2 | S387 | ochoa | Protein spire homolog 2 (Spir-2) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q8K1S6, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480}. |
Q8WYJ6 | SEPTIN1 | S312 | psp | Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}. |
Q92576 | PHF3 | S1362 | ochoa | PHD finger protein 3 | None |
Q92731 | ESR2 | S176 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
Q92766 | RREB1 | S1238 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
Q96AE4 | FUBP1 | S55 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
Q96PE2 | ARHGEF17 | S829 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q99569 | PKP4 | S214 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
Q9BRG2 | SH2D3A | S158 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
Q9BYB0 | SHANK3 | S1031 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9BZ72 | PITPNM2 | S1324 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
Q9GZM8 | NDEL1 | S306 | ochoa | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
Q9H0W8 | SMG9 | S53 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
Q9H3R0 | KDM4C | S918 | psp | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
Q9NQ84 | GPRC5C | S406 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
Q9NRD9 | DUOX1 | S637 | ochoa | Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}. |
Q9NT22 | EMILIN3 | S206 | ochoa | EMILIN-3 (EMILIN-5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5) | None |
Q9NX95 | SYBU | S71 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
Q9NYJ8 | TAB2 | S419 | psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}. |
Q9NYV4 | CDK12 | S886 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
Q9P266 | JCAD | S770 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
Q9UJK0 | TSR3 | S254 | ochoa | 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}. |
Q9UKS6 | PACSIN3 | S319 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
Q9UMS6 | SYNPO2 | S890 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9Y613 | FHOD1 | S367 | ochoa | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
Q9Y617 | PSAT1 | S226 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
O15146 | MUSK | S752 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
Q96ST3 | SIN3A | S158 | Sugiyama | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
P08754 | GNAI3 | S143 | Sugiyama | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
P25788 | PSMA3 | S97 | Sugiyama | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
Q14566 | MCM6 | S507 | Sugiyama | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
P36888 | FLT3 | S838 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
P43403 | ZAP70 | S263 | Sugiyama | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
P51451 | BLK | S387 | Sugiyama | Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). {ECO:0000250|UniProtKB:P16277, ECO:0000269|PubMed:19667185, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:8756631}. |
Q9UPQ9 | TNRC6B | S992 | Sugiyama | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
P52597 | HNRNPF | S279 | Sugiyama | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
Q01973 | ROR1 | S642 | Sugiyama | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350, ECO:0000269|PubMed:36949068}. |
Q9BTD8 | RBM42 | S433 | Sugiyama | RNA-binding protein 42 (RNA-binding motif protein 42) | Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. {ECO:0000250}. |
Q16620 | NTRK2 | S703 | Sugiyama | BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B) | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:15494731, PubMed:7574684). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}. |
Q16539 | MAPK14 | S261 | Sugiyama | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:9430721, PubMed:9858528). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}. |
Q16288 | NTRK3 | S706 | Sugiyama | NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}. |
Q59H18 | TNNI3K | S615 | Sugiyama | Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) | May play a role in cardiac physiology. {ECO:0000303|PubMed:12721663}. |
O43143 | DHX15 | S656 | Sugiyama | ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) | RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity). {ECO:0000250|UniProtKB:O35286, ECO:0000269|PubMed:19103666, ECO:0000269|PubMed:19432882, ECO:0000269|PubMed:24782566, ECO:0000269|PubMed:24990078, ECO:0000269|PubMed:32179686, ECO:0000269|PubMed:34161762}. |
Q96PY6 | NEK1 | S155 | Sugiyama | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
Q15154 | PCM1 | S580 | Sugiyama | Pericentriolar material 1 protein (PCM-1) (hPCM-1) | Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:34782749}. |
Q9NRA0 | SPHK2 | S377 | Sugiyama | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Q9UKI8 | TLK1 | S147 | Sugiyama | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.000046 | 4.339 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000027 | 4.568 |
R-HSA-187687 | Signalling to ERKs | 0.000057 | 4.242 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.000070 | 4.156 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.000044 | 4.357 |
R-HSA-187015 | Activation of TRKA receptors | 0.000131 | 3.884 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.000123 | 3.910 |
R-HSA-162582 | Signal Transduction | 0.000159 | 3.799 |
R-HSA-166520 | Signaling by NTRKs | 0.000210 | 3.678 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.000371 | 3.431 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.000478 | 3.321 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.000518 | 3.285 |
R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.000700 | 3.155 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.000765 | 3.116 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.000682 | 3.166 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.000744 | 3.128 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000643 | 3.192 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.000859 | 3.066 |
R-HSA-169893 | Prolonged ERK activation events | 0.000976 | 3.011 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.000933 | 3.030 |
R-HSA-187042 | TRKA activation by NGF | 0.001087 | 2.964 |
R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.002103 | 2.677 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.002287 | 2.641 |
R-HSA-167044 | Signalling to RAS | 0.002056 | 2.687 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.001478 | 2.830 |
R-HSA-187024 | NGF-independant TRKA activation | 0.002730 | 2.564 |
R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.002730 | 2.564 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.003434 | 2.464 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.004213 | 2.375 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.004213 | 2.375 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.003678 | 2.434 |
R-HSA-8939211 | ESR-mediated signaling | 0.003379 | 2.471 |
R-HSA-193648 | NRAGE signals death through JNK | 0.003424 | 2.465 |
R-HSA-418597 | G alpha (z) signalling events | 0.003238 | 2.490 |
R-HSA-525793 | Myogenesis | 0.003678 | 2.434 |
R-HSA-450294 | MAP kinase activation | 0.004461 | 2.351 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.005175 | 2.286 |
R-HSA-170984 | ARMS-mediated activation | 0.005993 | 2.222 |
R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.005993 | 2.222 |
R-HSA-376176 | Signaling by ROBO receptors | 0.005605 | 2.251 |
R-HSA-73887 | Death Receptor Signaling | 0.006328 | 2.199 |
R-HSA-448424 | Interleukin-17 signaling | 0.006824 | 2.166 |
R-HSA-202403 | TCR signaling | 0.006480 | 2.188 |
R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.006990 | 2.156 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.006990 | 2.156 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.007766 | 2.110 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.007273 | 2.138 |
R-HSA-392518 | Signal amplification | 0.007273 | 2.138 |
R-HSA-9702506 | Drug resistance of FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702509 | FLT3 mutants bind TKIs | 0.009457 | 2.024 |
R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702998 | linifanib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702569 | KW2449-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 0.009457 | 2.024 |
R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.008056 | 2.094 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.008128 | 2.090 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.011123 | 1.954 |
R-HSA-194138 | Signaling by VEGF | 0.011274 | 1.948 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.011405 | 1.943 |
R-HSA-170968 | Frs2-mediated activation | 0.011661 | 1.933 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.011752 | 1.930 |
R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.014387 | 1.842 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.014387 | 1.842 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.012993 | 1.886 |
R-HSA-171007 | p38MAPK events | 0.014387 | 1.842 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.014471 | 1.840 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.014471 | 1.840 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.015202 | 1.818 |
R-HSA-9706369 | Negative regulation of FLT3 | 0.015844 | 1.800 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.017360 | 1.760 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.017360 | 1.760 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.017552 | 1.756 |
R-HSA-9603505 | NTRK3 as a dependence receptor | 0.028104 | 1.551 |
R-HSA-205017 | NFG and proNGF binds to p75NTR | 0.028104 | 1.551 |
R-HSA-72649 | Translation initiation complex formation | 0.021789 | 1.662 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.023643 | 1.626 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.021435 | 1.669 |
R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.025807 | 1.588 |
R-HSA-198753 | ERK/MAPK targets | 0.025807 | 1.588 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.026579 | 1.575 |
R-HSA-5683057 | MAPK family signaling cascades | 0.024716 | 1.607 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.025807 | 1.588 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.025807 | 1.588 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.025580 | 1.592 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.028262 | 1.549 |
R-HSA-212436 | Generic Transcription Pathway | 0.024843 | 1.605 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.020169 | 1.695 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.020814 | 1.682 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.020814 | 1.682 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.020814 | 1.682 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.026093 | 1.583 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.021789 | 1.662 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.022960 | 1.639 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.020205 | 1.695 |
R-HSA-422475 | Axon guidance | 0.019853 | 1.702 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.018272 | 1.738 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.026804 | 1.572 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.029008 | 1.537 |
R-HSA-9675108 | Nervous system development | 0.029689 | 1.527 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.029765 | 1.526 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.029765 | 1.526 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.030784 | 1.512 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.031316 | 1.504 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.031316 | 1.504 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.032108 | 1.493 |
R-HSA-9025046 | NTF3 activates NTRK2 (TRKB) signaling | 0.037297 | 1.428 |
R-HSA-9026357 | NTF4 activates NTRK2 (TRKB) signaling | 0.037297 | 1.428 |
R-HSA-9024909 | BDNF activates NTRK2 (TRKB) signaling | 0.037297 | 1.428 |
R-HSA-198765 | Signalling to ERK5 | 0.037297 | 1.428 |
R-HSA-9034013 | NTF3 activates NTRK3 signaling | 0.037297 | 1.428 |
R-HSA-5662853 | Essential pentosuria | 0.037297 | 1.428 |
R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.037683 | 1.424 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.035318 | 1.452 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.039832 | 1.400 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.038873 | 1.410 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.038873 | 1.410 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.034557 | 1.461 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.038932 | 1.410 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.038873 | 1.410 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.037111 | 1.430 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.038624 | 1.413 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.041604 | 1.381 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.041604 | 1.381 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.044264 | 1.354 |
R-HSA-167021 | PLC-gamma1 signalling | 0.046403 | 1.333 |
R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.046403 | 1.333 |
R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.046403 | 1.333 |
R-HSA-209563 | Axonal growth stimulation | 0.046403 | 1.333 |
R-HSA-198745 | Signalling to STAT3 | 0.046403 | 1.333 |
R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.046403 | 1.333 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.046403 | 1.333 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.046403 | 1.333 |
R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.055424 | 1.256 |
R-HSA-205025 | NADE modulates death signalling | 0.055424 | 1.256 |
R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 0.055424 | 1.256 |
R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.064359 | 1.191 |
R-HSA-9032759 | NTRK2 activates RAC1 | 0.064359 | 1.191 |
R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.064359 | 1.191 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.073211 | 1.135 |
R-HSA-176417 | Phosphorylation of Emi1 | 0.073211 | 1.135 |
R-HSA-9645135 | STAT5 Activation | 0.081980 | 1.086 |
R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.090666 | 1.043 |
R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.090666 | 1.043 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.090666 | 1.043 |
R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.099271 | 1.003 |
R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.099271 | 1.003 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.099271 | 1.003 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.099271 | 1.003 |
R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.099271 | 1.003 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.099271 | 1.003 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.099271 | 1.003 |
R-HSA-193692 | Regulated proteolysis of p75NTR | 0.107794 | 0.967 |
R-HSA-390450 | Folding of actin by CCT/TriC | 0.116238 | 0.935 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.116238 | 0.935 |
R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.124602 | 0.904 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.124602 | 0.904 |
R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.132887 | 0.877 |
R-HSA-202670 | ERKs are inactivated | 0.132887 | 0.877 |
R-HSA-209543 | p75NTR recruits signalling complexes | 0.141095 | 0.850 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.141095 | 0.850 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.149225 | 0.826 |
R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.149225 | 0.826 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.149225 | 0.826 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.157279 | 0.803 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.165257 | 0.782 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.173161 | 0.762 |
R-HSA-5673000 | RAF activation | 0.058568 | 1.232 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.061088 | 1.214 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.180989 | 0.742 |
R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.180989 | 0.742 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.180989 | 0.742 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.066239 | 1.179 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.082497 | 1.084 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.093942 | 1.027 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.093942 | 1.027 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.093942 | 1.027 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.096871 | 1.014 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.099827 | 1.001 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.111891 | 0.951 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.114965 | 0.939 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.121176 | 0.917 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.070789 | 1.150 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.072450 | 1.140 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.079265 | 1.101 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.081011 | 1.091 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.153340 | 0.814 |
R-HSA-192823 | Viral mRNA Translation | 0.095565 | 1.020 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.105167 | 0.978 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.107131 | 0.970 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.053609 | 1.271 |
R-HSA-72172 | mRNA Splicing | 0.063635 | 1.196 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.178977 | 0.747 |
R-HSA-9607240 | FLT3 Signaling | 0.076950 | 1.114 |
R-HSA-193697 | p75NTR regulates axonogenesis | 0.107794 | 0.967 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.124312 | 0.905 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.079709 | 1.098 |
R-HSA-193639 | p75NTR signals via NF-kB | 0.165257 | 0.782 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.099271 | 1.003 |
R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.149225 | 0.826 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.079709 | 1.098 |
R-HSA-166665 | Terminal pathway of complement | 0.073211 | 1.135 |
R-HSA-198203 | PI3K/AKT activation | 0.116238 | 0.935 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.058149 | 1.235 |
R-HSA-156902 | Peptide chain elongation | 0.065914 | 1.181 |
R-HSA-6802949 | Signaling by RAS mutants | 0.093942 | 1.027 |
R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.099271 | 1.003 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.173355 | 0.761 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.173355 | 0.761 |
R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.064359 | 1.191 |
R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.116238 | 0.935 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.157279 | 0.803 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.114965 | 0.939 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.143516 | 0.843 |
R-HSA-69206 | G1/S Transition | 0.149207 | 0.826 |
R-HSA-991365 | Activation of GABAB receptors | 0.082497 | 1.084 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.072179 | 1.142 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.105812 | 0.975 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.081011 | 1.091 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 0.157279 | 0.803 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.066912 | 1.174 |
R-HSA-977444 | GABA B receptor activation | 0.082497 | 1.084 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.127538 | 0.894 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.127538 | 0.894 |
R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.046403 | 1.333 |
R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.055424 | 1.256 |
R-HSA-193681 | Ceramide signalling | 0.073211 | 1.135 |
R-HSA-176974 | Unwinding of DNA | 0.107794 | 0.967 |
R-HSA-209560 | NF-kB is activated and signals survival | 0.132887 | 0.877 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.149225 | 0.826 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.165257 | 0.782 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.058568 | 1.232 |
R-HSA-68949 | Orc1 removal from chromatin | 0.111891 | 0.951 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.176731 | 0.753 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.075663 | 1.121 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.070789 | 1.150 |
R-HSA-9948299 | Ribosome-associated quality control | 0.061361 | 1.212 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.074128 | 1.130 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.173355 | 0.761 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.082159 | 1.085 |
R-HSA-977443 | GABA receptor activation | 0.137045 | 0.863 |
R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.055424 | 1.256 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.090666 | 1.043 |
R-HSA-2129379 | Molecules associated with elastic fibres | 0.048869 | 1.311 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.093691 | 1.028 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.180119 | 0.744 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.074223 | 1.129 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.165257 | 0.782 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.081222 | 1.090 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.117166 | 0.931 |
R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.055424 | 1.256 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.073211 | 1.135 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.124602 | 0.904 |
R-HSA-1483226 | Synthesis of PI | 0.124602 | 0.904 |
R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.132887 | 0.877 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.132887 | 0.877 |
R-HSA-69481 | G2/M Checkpoints | 0.047385 | 1.324 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.107131 | 0.970 |
R-HSA-6794361 | Neurexins and neuroligins | 0.111891 | 0.951 |
R-HSA-1640170 | Cell Cycle | 0.088486 | 1.053 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.108840 | 0.963 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.053640 | 1.271 |
R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.180989 | 0.742 |
R-HSA-2408557 | Selenocysteine synthesis | 0.091831 | 1.037 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 0.093942 | 1.027 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.061088 | 1.214 |
R-HSA-9683686 | Maturation of spike protein | 0.116238 | 0.935 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.116238 | 0.935 |
R-HSA-425561 | Sodium/Calcium exchangers | 0.132887 | 0.877 |
R-HSA-428540 | Activation of RAC1 | 0.132887 | 0.877 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.141095 | 0.850 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.165257 | 0.782 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.097456 | 1.011 |
R-HSA-1566948 | Elastic fibre formation | 0.068867 | 1.162 |
R-HSA-202433 | Generation of second messenger molecules | 0.074223 | 1.129 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.088163 | 1.055 |
R-HSA-69236 | G1 Phase | 0.088163 | 1.055 |
R-HSA-74160 | Gene expression (Transcription) | 0.057297 | 1.242 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.143516 | 0.843 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.161937 | 0.791 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.059665 | 1.224 |
R-HSA-2559583 | Cellular Senescence | 0.122545 | 0.912 |
R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.107794 | 0.967 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.141095 | 0.850 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.141095 | 0.850 |
R-HSA-9005895 | Pervasive developmental disorders | 0.141095 | 0.850 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.149225 | 0.826 |
R-HSA-391160 | Signal regulatory protein family interactions | 0.157279 | 0.803 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.165257 | 0.782 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.173161 | 0.762 |
R-HSA-69541 | Stabilization of p53 | 0.071529 | 1.146 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.169988 | 0.770 |
R-HSA-4086398 | Ca2+ pathway | 0.180119 | 0.744 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.165257 | 0.782 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.180989 | 0.742 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.140272 | 0.853 |
R-HSA-390696 | Adrenoceptors | 0.099271 | 1.003 |
R-HSA-389359 | CD28 dependent Vav1 pathway | 0.149225 | 0.826 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.173161 | 0.762 |
R-HSA-5661270 | Formation of xylulose-5-phosphate | 0.180989 | 0.742 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.074707 | 1.127 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.059083 | 1.229 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.059665 | 1.224 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.079897 | 1.097 |
R-HSA-8953854 | Metabolism of RNA | 0.065030 | 1.187 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.106711 | 0.972 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.102807 | 0.988 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.102807 | 0.988 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.082773 | 1.082 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.135740 | 0.867 |
R-HSA-202424 | Downstream TCR signaling | 0.069146 | 1.160 |
R-HSA-112040 | G-protein mediated events | 0.159961 | 0.796 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.096871 | 1.014 |
R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.124602 | 0.904 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.140832 | 0.851 |
R-HSA-389356 | Co-stimulation by CD28 | 0.099827 | 1.001 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.176731 | 0.753 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.176731 | 0.753 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.108406 | 0.965 |
R-HSA-9020702 | Interleukin-1 signaling | 0.091831 | 1.037 |
R-HSA-168249 | Innate Immune System | 0.090779 | 1.042 |
R-HSA-9634597 | GPER1 signaling | 0.099827 | 1.001 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.169988 | 0.770 |
R-HSA-5689880 | Ub-specific processing proteases | 0.111481 | 0.953 |
R-HSA-5688426 | Deubiquitination | 0.122693 | 0.911 |
R-HSA-1266738 | Developmental Biology | 0.172822 | 0.762 |
R-HSA-3000178 | ECM proteoglycans | 0.173355 | 0.761 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.091039 | 1.041 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.176731 | 0.753 |
R-HSA-9658195 | Leishmania infection | 0.160042 | 0.796 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.160042 | 0.796 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.088163 | 1.055 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.063646 | 1.196 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.049447 | 1.306 |
R-HSA-9945266 | Differentiation of T cells | 0.173161 | 0.762 |
R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.173161 | 0.762 |
R-HSA-109582 | Hemostasis | 0.145348 | 0.838 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.071529 | 1.146 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.088915 | 1.051 |
R-HSA-8853659 | RET signaling | 0.063646 | 1.196 |
R-HSA-449147 | Signaling by Interleukins | 0.163165 | 0.787 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.099827 | 1.001 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.153340 | 0.814 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.140870 | 0.851 |
R-HSA-75893 | TNF signaling | 0.124312 | 0.905 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.183516 | 0.736 |
R-HSA-1236394 | Signaling by ERBB4 | 0.183516 | 0.736 |
R-HSA-195721 | Signaling by WNT | 0.186684 | 0.729 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.188745 | 0.724 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.188745 | 0.724 |
R-HSA-9020591 | Interleukin-12 signaling | 0.190338 | 0.720 |
R-HSA-3928664 | Ephrin signaling | 0.196427 | 0.707 |
R-HSA-432142 | Platelet sensitization by LDL | 0.196427 | 0.707 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.196427 | 0.707 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.196427 | 0.707 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.196786 | 0.706 |
R-HSA-168256 | Immune System | 0.196824 | 0.706 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.197195 | 0.705 |
R-HSA-4086400 | PCP/CE pathway | 0.197195 | 0.705 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.200463 | 0.698 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.204037 | 0.690 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.204037 | 0.690 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.204037 | 0.690 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.204037 | 0.690 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.204081 | 0.690 |
R-HSA-5654738 | Signaling by FGFR2 | 0.204081 | 0.690 |
R-HSA-69242 | S Phase | 0.210205 | 0.677 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.211575 | 0.675 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.211575 | 0.675 |
R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.211575 | 0.675 |
R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.211575 | 0.675 |
R-HSA-445144 | Signal transduction by L1 | 0.211575 | 0.675 |
R-HSA-373753 | Nephrin family interactions | 0.211575 | 0.675 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.214460 | 0.669 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.215115 | 0.667 |
R-HSA-1500931 | Cell-Cell communication | 0.216515 | 0.665 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.219042 | 0.659 |
R-HSA-72312 | rRNA processing | 0.219088 | 0.659 |
R-HSA-8953897 | Cellular responses to stimuli | 0.219110 | 0.659 |
R-HSA-446652 | Interleukin-1 family signaling | 0.220050 | 0.657 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.221407 | 0.655 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.224887 | 0.648 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.224887 | 0.648 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.226439 | 0.645 |
R-HSA-977347 | Serine metabolism | 0.226439 | 0.645 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.226439 | 0.645 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.226439 | 0.645 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.227495 | 0.643 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.228372 | 0.641 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.228506 | 0.641 |
R-HSA-70268 | Pyruvate metabolism | 0.231861 | 0.635 |
R-HSA-447115 | Interleukin-12 family signaling | 0.231861 | 0.635 |
R-HSA-1643685 | Disease | 0.233505 | 0.632 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.233767 | 0.631 |
R-HSA-9711097 | Cellular response to starvation | 0.234989 | 0.629 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.234989 | 0.629 |
R-HSA-157118 | Signaling by NOTCH | 0.235179 | 0.629 |
R-HSA-9006936 | Signaling by TGFB family members | 0.240009 | 0.620 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.240009 | 0.620 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.241026 | 0.618 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.241026 | 0.618 |
R-HSA-3000170 | Syndecan interactions | 0.241026 | 0.618 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.241026 | 0.618 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.245846 | 0.609 |
R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.248216 | 0.605 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.248216 | 0.605 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.248216 | 0.605 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.248216 | 0.605 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.248216 | 0.605 |
R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.248216 | 0.605 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.248216 | 0.605 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.248216 | 0.605 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.248216 | 0.605 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.250103 | 0.602 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.250103 | 0.602 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.252851 | 0.597 |
R-HSA-9839394 | TGFBR3 expression | 0.255338 | 0.593 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.255338 | 0.593 |
R-HSA-3214842 | HDMs demethylate histones | 0.255338 | 0.593 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.256356 | 0.591 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.262394 | 0.581 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.267915 | 0.572 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.268151 | 0.572 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.269383 | 0.570 |
R-HSA-8949613 | Cristae formation | 0.269383 | 0.570 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.269383 | 0.570 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.269383 | 0.570 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.269383 | 0.570 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.273889 | 0.562 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.275595 | 0.560 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.275595 | 0.560 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.275595 | 0.560 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.275595 | 0.560 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.276306 | 0.559 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.276306 | 0.559 |
R-HSA-422356 | Regulation of insulin secretion | 0.277395 | 0.557 |
R-HSA-190236 | Signaling by FGFR | 0.277395 | 0.557 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.278161 | 0.556 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.280729 | 0.552 |
R-HSA-209968 | Thyroxine biosynthesis | 0.283164 | 0.548 |
R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.283164 | 0.548 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.283164 | 0.548 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.283164 | 0.548 |
R-HSA-418360 | Platelet calcium homeostasis | 0.283164 | 0.548 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.284403 | 0.546 |
R-HSA-2262752 | Cellular responses to stress | 0.284419 | 0.546 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.289958 | 0.538 |
R-HSA-2424491 | DAP12 signaling | 0.289958 | 0.538 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.289958 | 0.538 |
R-HSA-114452 | Activation of BH3-only proteins | 0.289958 | 0.538 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.289958 | 0.538 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.289958 | 0.538 |
R-HSA-168255 | Influenza Infection | 0.291022 | 0.536 |
R-HSA-73894 | DNA Repair | 0.294666 | 0.531 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.296687 | 0.528 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.296687 | 0.528 |
R-HSA-111885 | Opioid Signalling | 0.298400 | 0.525 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.298400 | 0.525 |
R-HSA-1538133 | G0 and Early G1 | 0.303354 | 0.518 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.303354 | 0.518 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.303354 | 0.518 |
R-HSA-69190 | DNA strand elongation | 0.303354 | 0.518 |
R-HSA-9679506 | SARS-CoV Infections | 0.308154 | 0.511 |
R-HSA-418346 | Platelet homeostasis | 0.308871 | 0.510 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.309957 | 0.509 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.309957 | 0.509 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.309957 | 0.509 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.309957 | 0.509 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.309957 | 0.509 |
R-HSA-69239 | Synthesis of DNA | 0.312355 | 0.505 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.312355 | 0.505 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.312355 | 0.505 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.315836 | 0.501 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.315836 | 0.501 |
R-HSA-390522 | Striated Muscle Contraction | 0.316498 | 0.500 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.316498 | 0.500 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.316498 | 0.500 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 0.316498 | 0.500 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.316498 | 0.500 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.316498 | 0.500 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.319312 | 0.496 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.319312 | 0.496 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.322978 | 0.491 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.322978 | 0.491 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.322978 | 0.491 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.322978 | 0.491 |
R-HSA-901042 | Calnexin/calreticulin cycle | 0.322978 | 0.491 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.322978 | 0.491 |
R-HSA-6803157 | Antimicrobial peptides | 0.326252 | 0.486 |
R-HSA-68877 | Mitotic Prometaphase | 0.327211 | 0.485 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.329397 | 0.482 |
R-HSA-169911 | Regulation of Apoptosis | 0.329397 | 0.482 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.329397 | 0.482 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.329397 | 0.482 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.334977 | 0.475 |
R-HSA-69205 | G1/S-Specific Transcription | 0.335755 | 0.474 |
R-HSA-9682385 | FLT3 signaling in disease | 0.335755 | 0.474 |
R-HSA-114604 | GPVI-mediated activation cascade | 0.335755 | 0.474 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.335755 | 0.474 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.335755 | 0.474 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.335755 | 0.474 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.336628 | 0.473 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.336628 | 0.473 |
R-HSA-68886 | M Phase | 0.337369 | 0.472 |
R-HSA-4641258 | Degradation of DVL | 0.342053 | 0.466 |
R-HSA-4641257 | Degradation of AXIN | 0.342053 | 0.466 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.342053 | 0.466 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.342053 | 0.466 |
R-HSA-549127 | SLC-mediated transport of organic cations | 0.342053 | 0.466 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.342053 | 0.466 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.342053 | 0.466 |
R-HSA-388396 | GPCR downstream signalling | 0.343793 | 0.464 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.347413 | 0.459 |
R-HSA-373760 | L1CAM interactions | 0.350388 | 0.455 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.354472 | 0.450 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.354472 | 0.450 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.354472 | 0.450 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.354472 | 0.450 |
R-HSA-201556 | Signaling by ALK | 0.354472 | 0.450 |
R-HSA-5693538 | Homology Directed Repair | 0.357233 | 0.447 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.360594 | 0.443 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.360594 | 0.443 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.360594 | 0.443 |
R-HSA-8982491 | Glycogen metabolism | 0.360594 | 0.443 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.366658 | 0.436 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.366658 | 0.436 |
R-HSA-9694548 | Maturation of spike protein | 0.366658 | 0.436 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.366658 | 0.436 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.366658 | 0.436 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.366658 | 0.436 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.366658 | 0.436 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.366658 | 0.436 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.367451 | 0.435 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.372665 | 0.429 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.372665 | 0.429 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.372665 | 0.429 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.372665 | 0.429 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.372665 | 0.429 |
R-HSA-9683701 | Translation of Structural Proteins | 0.372665 | 0.429 |
R-HSA-397014 | Muscle contraction | 0.378836 | 0.422 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.381402 | 0.419 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.384340 | 0.415 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.384340 | 0.415 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.384340 | 0.415 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.384510 | 0.415 |
R-HSA-8854214 | TBC/RABGAPs | 0.384510 | 0.415 |
R-HSA-5654743 | Signaling by FGFR4 | 0.384510 | 0.415 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.384510 | 0.415 |
R-HSA-68882 | Mitotic Anaphase | 0.389085 | 0.410 |
R-HSA-9907900 | Proteasome assembly | 0.390349 | 0.409 |
R-HSA-2172127 | DAP12 interactions | 0.390349 | 0.409 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.390349 | 0.409 |
R-HSA-375280 | Amine ligand-binding receptors | 0.390349 | 0.409 |
R-HSA-5683826 | Surfactant metabolism | 0.390349 | 0.409 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.391641 | 0.407 |
R-HSA-418990 | Adherens junctions interactions | 0.394194 | 0.404 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.396133 | 0.402 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.396133 | 0.402 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.396133 | 0.402 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.396133 | 0.402 |
R-HSA-9824272 | Somitogenesis | 0.396133 | 0.402 |
R-HSA-5654741 | Signaling by FGFR3 | 0.396133 | 0.402 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.396133 | 0.402 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.396133 | 0.402 |
R-HSA-1489509 | DAG and IP3 signaling | 0.396133 | 0.402 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.401862 | 0.396 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.401862 | 0.396 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.401862 | 0.396 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.407538 | 0.390 |
R-HSA-437239 | Recycling pathway of L1 | 0.407538 | 0.390 |
R-HSA-9909396 | Circadian clock | 0.410951 | 0.386 |
R-HSA-425410 | Metal ion SLC transporters | 0.413159 | 0.384 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.418728 | 0.378 |
R-HSA-9766229 | Degradation of CDH1 | 0.418728 | 0.378 |
R-HSA-73893 | DNA Damage Bypass | 0.418728 | 0.378 |
R-HSA-109704 | PI3K Cascade | 0.424245 | 0.372 |
R-HSA-9748787 | Azathioprine ADME | 0.424245 | 0.372 |
R-HSA-163685 | Integration of energy metabolism | 0.427297 | 0.369 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.429709 | 0.367 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.429709 | 0.367 |
R-HSA-1280218 | Adaptive Immune System | 0.434763 | 0.362 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.435122 | 0.361 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.435122 | 0.361 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.435122 | 0.361 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.435122 | 0.361 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.435122 | 0.361 |
R-HSA-6807070 | PTEN Regulation | 0.436992 | 0.360 |
R-HSA-9664407 | Parasite infection | 0.440204 | 0.356 |
R-HSA-9664417 | Leishmania phagocytosis | 0.440204 | 0.356 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.440204 | 0.356 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.440483 | 0.356 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.440483 | 0.356 |
R-HSA-445355 | Smooth Muscle Contraction | 0.440483 | 0.356 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.440483 | 0.356 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.443406 | 0.353 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.445795 | 0.351 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.449780 | 0.347 |
R-HSA-209776 | Metabolism of amine-derived hormones | 0.456267 | 0.341 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.456267 | 0.341 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.456267 | 0.341 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.456267 | 0.341 |
R-HSA-5578775 | Ion homeostasis | 0.456267 | 0.341 |
R-HSA-5654736 | Signaling by FGFR1 | 0.456267 | 0.341 |
R-HSA-372790 | Signaling by GPCR | 0.456414 | 0.341 |
R-HSA-112399 | IRS-mediated signalling | 0.461429 | 0.336 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.461429 | 0.336 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.461429 | 0.336 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.466543 | 0.331 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.466543 | 0.331 |
R-HSA-421270 | Cell-cell junction organization | 0.476473 | 0.322 |
R-HSA-983189 | Kinesins | 0.476626 | 0.322 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.476626 | 0.322 |
R-HSA-351202 | Metabolism of polyamines | 0.476626 | 0.322 |
R-HSA-5362517 | Signaling by Retinoic Acid | 0.476626 | 0.322 |
R-HSA-1227986 | Signaling by ERBB2 | 0.476626 | 0.322 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.481596 | 0.317 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.481596 | 0.317 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.481596 | 0.317 |
R-HSA-69306 | DNA Replication | 0.484087 | 0.315 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.486520 | 0.313 |
R-HSA-1268020 | Mitochondrial protein import | 0.486520 | 0.313 |
R-HSA-9707616 | Heme signaling | 0.486520 | 0.313 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.487141 | 0.312 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.491396 | 0.309 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.491396 | 0.309 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.491396 | 0.309 |
R-HSA-373755 | Semaphorin interactions | 0.491396 | 0.309 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.491396 | 0.309 |
R-HSA-2428924 | IGF1R signaling cascade | 0.496227 | 0.304 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.496227 | 0.304 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.496234 | 0.304 |
R-HSA-112316 | Neuronal System | 0.497251 | 0.303 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.501013 | 0.300 |
R-HSA-1234174 | Cellular response to hypoxia | 0.501013 | 0.300 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.505753 | 0.296 |
R-HSA-416476 | G alpha (q) signalling events | 0.507501 | 0.295 |
R-HSA-109581 | Apoptosis | 0.511163 | 0.291 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.515099 | 0.288 |
R-HSA-9711123 | Cellular response to chemical stress | 0.516858 | 0.287 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.524270 | 0.280 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.524270 | 0.280 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.528791 | 0.277 |
R-HSA-5632684 | Hedgehog 'on' state | 0.528791 | 0.277 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.528791 | 0.277 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.536531 | 0.270 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.537704 | 0.269 |
R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.537704 | 0.269 |
R-HSA-446728 | Cell junction organization | 0.539832 | 0.268 |
R-HSA-418555 | G alpha (s) signalling events | 0.540143 | 0.267 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.542098 | 0.266 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.542098 | 0.266 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.542976 | 0.265 |
R-HSA-380287 | Centrosome maturation | 0.546450 | 0.262 |
R-HSA-8852135 | Protein ubiquitination | 0.546450 | 0.262 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.546450 | 0.262 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.548847 | 0.261 |
R-HSA-5689603 | UCH proteinases | 0.550761 | 0.259 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.555032 | 0.256 |
R-HSA-9694635 | Translation of Structural Proteins | 0.555032 | 0.256 |
R-HSA-216083 | Integrin cell surface interactions | 0.559262 | 0.252 |
R-HSA-5619084 | ABC transporter disorders | 0.559262 | 0.252 |
R-HSA-9659379 | Sensory processing of sound | 0.563452 | 0.249 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.563452 | 0.249 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.567603 | 0.246 |
R-HSA-9833482 | PKR-mediated signaling | 0.567603 | 0.246 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.569162 | 0.245 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.571714 | 0.243 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.571714 | 0.243 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.573336 | 0.242 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.575787 | 0.240 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.575787 | 0.240 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.579821 | 0.237 |
R-HSA-69275 | G2/M Transition | 0.581360 | 0.236 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.583817 | 0.234 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.586648 | 0.232 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.591696 | 0.228 |
R-HSA-5617833 | Cilium Assembly | 0.591887 | 0.228 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.597076 | 0.224 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.599426 | 0.222 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.603237 | 0.220 |
R-HSA-9645723 | Diseases of programmed cell death | 0.603237 | 0.220 |
R-HSA-1236974 | ER-Phagosome pathway | 0.607012 | 0.217 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.610751 | 0.214 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.617343 | 0.209 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.618123 | 0.209 |
R-HSA-72766 | Translation | 0.621721 | 0.206 |
R-HSA-391251 | Protein folding | 0.621757 | 0.206 |
R-HSA-74752 | Signaling by Insulin receptor | 0.621757 | 0.206 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.621757 | 0.206 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.625357 | 0.204 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.628922 | 0.201 |
R-HSA-5357801 | Programmed Cell Death | 0.632027 | 0.199 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.635953 | 0.197 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.639418 | 0.194 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.639418 | 0.194 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.639418 | 0.194 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.648604 | 0.188 |
R-HSA-9614085 | FOXO-mediated transcription | 0.649619 | 0.187 |
R-HSA-1474244 | Extracellular matrix organization | 0.650462 | 0.187 |
R-HSA-5610787 | Hedgehog 'off' state | 0.652955 | 0.185 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.652955 | 0.185 |
R-HSA-6798695 | Neutrophil degranulation | 0.668547 | 0.175 |
R-HSA-8951664 | Neddylation | 0.669046 | 0.175 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.669096 | 0.175 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.669168 | 0.174 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.669168 | 0.174 |
R-HSA-211000 | Gene Silencing by RNA | 0.678532 | 0.168 |
R-HSA-2672351 | Stimuli-sensing channels | 0.681595 | 0.166 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.693558 | 0.159 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.696877 | 0.157 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.705074 | 0.152 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.707885 | 0.150 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.707885 | 0.150 |
R-HSA-9007101 | Rab regulation of trafficking | 0.713428 | 0.147 |
R-HSA-68875 | Mitotic Prophase | 0.721547 | 0.142 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.724202 | 0.140 |
R-HSA-4839726 | Chromatin organization | 0.726571 | 0.139 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.729437 | 0.137 |
R-HSA-6809371 | Formation of the cornified envelope | 0.732018 | 0.135 |
R-HSA-162909 | Host Interactions of HIV factors | 0.732018 | 0.135 |
R-HSA-977606 | Regulation of Complement cascade | 0.734574 | 0.134 |
R-HSA-114608 | Platelet degranulation | 0.742097 | 0.130 |
R-HSA-9734767 | Developmental Cell Lineages | 0.752045 | 0.124 |
R-HSA-9843745 | Adipogenesis | 0.754169 | 0.123 |
R-HSA-5576891 | Cardiac conduction | 0.754169 | 0.123 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.756515 | 0.121 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.758839 | 0.120 |
R-HSA-5173105 | O-linked glycosylation | 0.770131 | 0.113 |
R-HSA-5358351 | Signaling by Hedgehog | 0.772326 | 0.112 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.774500 | 0.111 |
R-HSA-418594 | G alpha (i) signalling events | 0.775423 | 0.110 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.785064 | 0.105 |
R-HSA-166658 | Complement cascade | 0.789150 | 0.103 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.793160 | 0.101 |
R-HSA-9758941 | Gastrulation | 0.797093 | 0.098 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.800952 | 0.096 |
R-HSA-9609507 | Protein localization | 0.804739 | 0.094 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.806605 | 0.093 |
R-HSA-1989781 | PPARA activates gene expression | 0.808453 | 0.092 |
R-HSA-597592 | Post-translational protein modification | 0.818853 | 0.087 |
R-HSA-5663205 | Infectious disease | 0.838569 | 0.076 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.839366 | 0.076 |
R-HSA-392499 | Metabolism of proteins | 0.850703 | 0.070 |
R-HSA-9824446 | Viral Infection Pathways | 0.860269 | 0.065 |
R-HSA-983712 | Ion channel transport | 0.863189 | 0.064 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.876939 | 0.057 |
R-HSA-428157 | Sphingolipid metabolism | 0.878118 | 0.056 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.879287 | 0.056 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.880444 | 0.055 |
R-HSA-199991 | Membrane Trafficking | 0.883110 | 0.054 |
R-HSA-6805567 | Keratinization | 0.884964 | 0.053 |
R-HSA-9748784 | Drug ADME | 0.897531 | 0.047 |
R-HSA-162906 | HIV Infection | 0.906052 | 0.043 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.907068 | 0.042 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.909211 | 0.041 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.922550 | 0.035 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.925359 | 0.034 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.942578 | 0.026 |
R-HSA-1483257 | Phospholipid metabolism | 0.951325 | 0.022 |
R-HSA-5653656 | Vesicle-mediated transport | 0.957813 | 0.019 |
R-HSA-8957322 | Metabolism of steroids | 0.963260 | 0.016 |
R-HSA-913531 | Interferon Signaling | 0.979504 | 0.009 |
R-HSA-500792 | GPCR ligand binding | 0.980920 | 0.008 |
R-HSA-5668914 | Diseases of metabolism | 0.986659 | 0.006 |
R-HSA-382551 | Transport of small molecules | 0.987437 | 0.005 |
R-HSA-556833 | Metabolism of lipids | 0.999772 | 0.000 |
R-HSA-1430728 | Metabolism | 0.999965 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999996 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.860 | 0.109 | 2 | 0.896 |
RSK2 |
0.855 | 0.219 | -3 | 0.758 |
PIM3 |
0.854 | 0.181 | -3 | 0.821 |
WNK1 |
0.853 | 0.261 | -2 | 0.855 |
PRKD2 |
0.849 | 0.183 | -3 | 0.760 |
AURC |
0.849 | 0.285 | -2 | 0.725 |
PIM1 |
0.848 | 0.211 | -3 | 0.764 |
CAMK1B |
0.848 | 0.140 | -3 | 0.851 |
NDR2 |
0.848 | 0.123 | -3 | 0.835 |
NDR1 |
0.847 | 0.188 | -3 | 0.826 |
CLK3 |
0.847 | 0.193 | 1 | 0.771 |
PRKD1 |
0.847 | 0.122 | -3 | 0.818 |
PRPK |
0.846 | -0.018 | -1 | 0.836 |
PKACG |
0.846 | 0.220 | -2 | 0.755 |
RSK3 |
0.846 | 0.164 | -3 | 0.750 |
P90RSK |
0.845 | 0.148 | -3 | 0.755 |
CDC7 |
0.845 | 0.018 | 1 | 0.839 |
CAMK2G |
0.845 | 0.087 | 2 | 0.889 |
PAK1 |
0.844 | 0.231 | -2 | 0.828 |
MOS |
0.844 | 0.055 | 1 | 0.882 |
RAF1 |
0.844 | -0.002 | 1 | 0.849 |
CDKL5 |
0.843 | 0.137 | -3 | 0.779 |
CDKL1 |
0.843 | 0.108 | -3 | 0.785 |
P70S6KB |
0.843 | 0.172 | -3 | 0.785 |
IKKB |
0.842 | -0.059 | -2 | 0.714 |
GCN2 |
0.842 | -0.087 | 2 | 0.827 |
TBK1 |
0.842 | -0.024 | 1 | 0.762 |
PKCD |
0.842 | 0.188 | 2 | 0.845 |
PDHK4 |
0.842 | -0.108 | 1 | 0.847 |
PAK3 |
0.842 | 0.208 | -2 | 0.825 |
MAPKAPK3 |
0.841 | 0.100 | -3 | 0.773 |
TSSK2 |
0.841 | 0.168 | -5 | 0.775 |
NIK |
0.841 | 0.185 | -3 | 0.874 |
PKN3 |
0.841 | 0.090 | -3 | 0.815 |
AMPKA1 |
0.841 | 0.157 | -3 | 0.848 |
DSTYK |
0.841 | -0.001 | 2 | 0.903 |
AURB |
0.841 | 0.270 | -2 | 0.720 |
CAMK2D |
0.841 | 0.104 | -3 | 0.844 |
CAMLCK |
0.841 | 0.184 | -2 | 0.862 |
PKACB |
0.840 | 0.248 | -2 | 0.715 |
LATS2 |
0.840 | 0.115 | -5 | 0.716 |
MARK4 |
0.840 | 0.080 | 4 | 0.814 |
ULK2 |
0.839 | -0.048 | 2 | 0.807 |
RSK4 |
0.839 | 0.209 | -3 | 0.724 |
SRPK1 |
0.839 | 0.139 | -3 | 0.724 |
ATR |
0.839 | 0.010 | 1 | 0.808 |
SKMLCK |
0.839 | 0.140 | -2 | 0.851 |
PKN2 |
0.839 | 0.131 | -3 | 0.824 |
NUAK2 |
0.839 | 0.096 | -3 | 0.826 |
NLK |
0.839 | 0.033 | 1 | 0.781 |
IKKE |
0.838 | -0.051 | 1 | 0.760 |
MTOR |
0.838 | -0.083 | 1 | 0.760 |
MST4 |
0.838 | 0.128 | 2 | 0.832 |
DAPK2 |
0.838 | 0.155 | -3 | 0.862 |
WNK3 |
0.838 | 0.048 | 1 | 0.833 |
HIPK4 |
0.838 | 0.111 | 1 | 0.767 |
RIPK3 |
0.837 | 0.033 | 3 | 0.732 |
ERK5 |
0.837 | 0.032 | 1 | 0.772 |
MSK2 |
0.837 | 0.135 | -3 | 0.726 |
MNK1 |
0.836 | 0.232 | -2 | 0.823 |
TSSK1 |
0.836 | 0.153 | -3 | 0.870 |
PKCG |
0.836 | 0.193 | 2 | 0.798 |
PDHK1 |
0.836 | -0.113 | 1 | 0.847 |
PKG2 |
0.836 | 0.218 | -2 | 0.716 |
AMPKA2 |
0.836 | 0.143 | -3 | 0.814 |
PKCA |
0.836 | 0.192 | 2 | 0.782 |
MNK2 |
0.836 | 0.199 | -2 | 0.816 |
BMPR2 |
0.835 | -0.128 | -2 | 0.825 |
PRKX |
0.835 | 0.243 | -3 | 0.659 |
HUNK |
0.835 | 0.010 | 2 | 0.788 |
PIM2 |
0.834 | 0.218 | -3 | 0.732 |
ICK |
0.834 | 0.107 | -3 | 0.822 |
PAK6 |
0.834 | 0.198 | -2 | 0.790 |
MAPKAPK2 |
0.834 | 0.084 | -3 | 0.717 |
PAK2 |
0.834 | 0.193 | -2 | 0.820 |
IRE1 |
0.834 | 0.101 | 1 | 0.826 |
SGK3 |
0.833 | 0.209 | -3 | 0.752 |
MSK1 |
0.833 | 0.182 | -3 | 0.732 |
CAMK2A |
0.833 | 0.148 | 2 | 0.883 |
PKCB |
0.833 | 0.165 | 2 | 0.790 |
PRKD3 |
0.832 | 0.120 | -3 | 0.726 |
MLK1 |
0.832 | -0.012 | 2 | 0.839 |
CAMK2B |
0.832 | 0.120 | 2 | 0.862 |
CAMK4 |
0.832 | 0.074 | -3 | 0.815 |
MELK |
0.831 | 0.108 | -3 | 0.802 |
GRK1 |
0.831 | 0.023 | -2 | 0.760 |
MYLK4 |
0.830 | 0.164 | -2 | 0.800 |
CHAK2 |
0.830 | -0.011 | -1 | 0.848 |
BCKDK |
0.830 | -0.077 | -1 | 0.766 |
PKCZ |
0.830 | 0.157 | 2 | 0.814 |
NEK6 |
0.830 | -0.038 | -2 | 0.768 |
DYRK2 |
0.829 | 0.096 | 1 | 0.660 |
QIK |
0.829 | 0.079 | -3 | 0.836 |
TGFBR2 |
0.829 | -0.057 | -2 | 0.719 |
RIPK1 |
0.829 | 0.015 | 1 | 0.828 |
PKCH |
0.828 | 0.150 | 2 | 0.776 |
CLK4 |
0.828 | 0.164 | -3 | 0.744 |
BRSK1 |
0.828 | 0.081 | -3 | 0.783 |
SRPK2 |
0.828 | 0.095 | -3 | 0.650 |
NIM1 |
0.827 | 0.008 | 3 | 0.770 |
AKT2 |
0.827 | 0.163 | -3 | 0.667 |
GRK5 |
0.827 | -0.122 | -3 | 0.848 |
PKR |
0.827 | 0.164 | 1 | 0.863 |
QSK |
0.827 | 0.084 | 4 | 0.794 |
MLK2 |
0.827 | -0.001 | 2 | 0.829 |
PKACA |
0.827 | 0.210 | -2 | 0.677 |
NEK2 |
0.826 | 0.098 | 2 | 0.818 |
SSTK |
0.826 | 0.204 | 4 | 0.792 |
IRE2 |
0.826 | 0.076 | 2 | 0.794 |
SRPK3 |
0.826 | 0.094 | -3 | 0.696 |
NEK7 |
0.826 | -0.132 | -3 | 0.853 |
FAM20C |
0.826 | 0.058 | 2 | 0.644 |
NEK9 |
0.826 | -0.052 | 2 | 0.842 |
MASTL |
0.826 | -0.152 | -2 | 0.776 |
ULK1 |
0.825 | -0.138 | -3 | 0.812 |
HIPK1 |
0.825 | 0.162 | 1 | 0.677 |
GRK6 |
0.825 | -0.037 | 1 | 0.823 |
WNK4 |
0.824 | 0.188 | -2 | 0.848 |
AURA |
0.824 | 0.170 | -2 | 0.702 |
BRSK2 |
0.824 | 0.055 | -3 | 0.817 |
TTBK2 |
0.824 | -0.083 | 2 | 0.734 |
CLK1 |
0.824 | 0.154 | -3 | 0.723 |
CDK8 |
0.823 | -0.026 | 1 | 0.600 |
MLK3 |
0.823 | 0.024 | 2 | 0.795 |
AKT1 |
0.823 | 0.203 | -3 | 0.689 |
SIK |
0.823 | 0.058 | -3 | 0.749 |
CAMK1G |
0.823 | 0.100 | -3 | 0.748 |
ANKRD3 |
0.823 | -0.067 | 1 | 0.864 |
IKKA |
0.822 | -0.105 | -2 | 0.686 |
LATS1 |
0.822 | 0.072 | -3 | 0.852 |
PHKG1 |
0.821 | 0.050 | -3 | 0.819 |
HIPK3 |
0.821 | 0.128 | 1 | 0.679 |
CDK7 |
0.821 | 0.000 | 1 | 0.606 |
CLK2 |
0.821 | 0.177 | -3 | 0.727 |
MARK3 |
0.821 | 0.058 | 4 | 0.746 |
CHK1 |
0.821 | 0.058 | -3 | 0.836 |
DLK |
0.821 | -0.125 | 1 | 0.815 |
DNAPK |
0.821 | 0.071 | 1 | 0.689 |
ATM |
0.821 | -0.029 | 1 | 0.750 |
PKCT |
0.821 | 0.171 | 2 | 0.783 |
CDK19 |
0.820 | -0.013 | 1 | 0.558 |
NUAK1 |
0.820 | 0.012 | -3 | 0.784 |
HIPK2 |
0.820 | 0.098 | 1 | 0.563 |
DYRK3 |
0.819 | 0.175 | 1 | 0.695 |
PKCI |
0.818 | 0.183 | 2 | 0.789 |
MARK2 |
0.818 | 0.024 | 4 | 0.720 |
SMMLCK |
0.817 | 0.151 | -3 | 0.806 |
ALK4 |
0.817 | -0.049 | -2 | 0.760 |
P70S6K |
0.817 | 0.100 | -3 | 0.697 |
PHKG2 |
0.817 | 0.108 | -3 | 0.783 |
PAK5 |
0.817 | 0.178 | -2 | 0.730 |
PLK1 |
0.817 | -0.073 | -2 | 0.721 |
IRAK4 |
0.817 | 0.117 | 1 | 0.830 |
SNRK |
0.817 | -0.038 | 2 | 0.696 |
MLK4 |
0.817 | -0.009 | 2 | 0.775 |
CHAK1 |
0.816 | -0.027 | 2 | 0.760 |
CAMK1D |
0.816 | 0.125 | -3 | 0.684 |
PKCE |
0.816 | 0.199 | 2 | 0.774 |
MARK1 |
0.816 | 0.030 | 4 | 0.771 |
MAPKAPK5 |
0.816 | -0.033 | -3 | 0.715 |
VRK2 |
0.816 | -0.069 | 1 | 0.869 |
DCAMKL1 |
0.815 | 0.091 | -3 | 0.770 |
PLK3 |
0.815 | -0.029 | 2 | 0.808 |
SMG1 |
0.815 | -0.063 | 1 | 0.765 |
YSK4 |
0.815 | -0.065 | 1 | 0.784 |
PAK4 |
0.815 | 0.178 | -2 | 0.737 |
CDK18 |
0.814 | 0.019 | 1 | 0.531 |
DYRK1B |
0.814 | 0.094 | 1 | 0.601 |
KIS |
0.813 | -0.061 | 1 | 0.629 |
GRK4 |
0.813 | -0.180 | -2 | 0.756 |
BMPR1B |
0.813 | 0.003 | 1 | 0.772 |
DYRK4 |
0.813 | 0.071 | 1 | 0.565 |
MEK1 |
0.813 | -0.140 | 2 | 0.838 |
P38A |
0.813 | 0.006 | 1 | 0.645 |
DAPK3 |
0.812 | 0.199 | -3 | 0.782 |
TGFBR1 |
0.812 | -0.044 | -2 | 0.720 |
AKT3 |
0.812 | 0.190 | -3 | 0.600 |
BRAF |
0.812 | -0.003 | -4 | 0.716 |
MPSK1 |
0.812 | 0.146 | 1 | 0.842 |
MRCKB |
0.812 | 0.233 | -3 | 0.723 |
DYRK1A |
0.811 | 0.054 | 1 | 0.678 |
JNK3 |
0.811 | -0.013 | 1 | 0.580 |
JNK2 |
0.811 | 0.005 | 1 | 0.535 |
PERK |
0.811 | -0.044 | -2 | 0.768 |
CDK13 |
0.810 | -0.040 | 1 | 0.576 |
CDK9 |
0.810 | -0.020 | 1 | 0.584 |
CDK10 |
0.809 | 0.101 | 1 | 0.563 |
ROCK2 |
0.809 | 0.259 | -3 | 0.775 |
MST3 |
0.809 | 0.105 | 2 | 0.827 |
ALK2 |
0.809 | -0.024 | -2 | 0.730 |
CDK5 |
0.809 | -0.004 | 1 | 0.628 |
DRAK1 |
0.809 | -0.044 | 1 | 0.718 |
TLK2 |
0.808 | -0.099 | 1 | 0.822 |
SGK1 |
0.808 | 0.163 | -3 | 0.586 |
NEK5 |
0.808 | 0.025 | 1 | 0.850 |
MOK |
0.808 | 0.229 | 1 | 0.717 |
MEKK1 |
0.807 | -0.047 | 1 | 0.827 |
HRI |
0.807 | -0.089 | -2 | 0.779 |
ERK1 |
0.807 | -0.010 | 1 | 0.553 |
CDK14 |
0.807 | 0.039 | 1 | 0.580 |
PKN1 |
0.807 | 0.103 | -3 | 0.715 |
PINK1 |
0.807 | -0.073 | 1 | 0.828 |
CDK12 |
0.807 | -0.021 | 1 | 0.545 |
MRCKA |
0.806 | 0.211 | -3 | 0.745 |
MEK5 |
0.806 | -0.093 | 2 | 0.826 |
DAPK1 |
0.806 | 0.163 | -3 | 0.761 |
DMPK1 |
0.805 | 0.285 | -3 | 0.737 |
PLK4 |
0.805 | -0.089 | 2 | 0.638 |
P38B |
0.805 | -0.011 | 1 | 0.562 |
CDK1 |
0.805 | -0.032 | 1 | 0.545 |
DCAMKL2 |
0.805 | 0.010 | -3 | 0.797 |
ACVR2A |
0.804 | -0.089 | -2 | 0.713 |
CDK17 |
0.804 | -0.018 | 1 | 0.468 |
CAMKK1 |
0.804 | -0.006 | -2 | 0.741 |
ZAK |
0.804 | -0.077 | 1 | 0.779 |
PASK |
0.804 | 0.033 | -3 | 0.837 |
ERK2 |
0.804 | -0.035 | 1 | 0.592 |
MEKK3 |
0.804 | -0.120 | 1 | 0.802 |
CAMKK2 |
0.803 | 0.042 | -2 | 0.747 |
LKB1 |
0.803 | 0.068 | -3 | 0.854 |
MAK |
0.803 | 0.156 | -2 | 0.768 |
GRK7 |
0.803 | -0.048 | 1 | 0.746 |
BUB1 |
0.803 | 0.180 | -5 | 0.732 |
MEKK2 |
0.803 | -0.057 | 2 | 0.824 |
TTBK1 |
0.802 | -0.100 | 2 | 0.664 |
ACVR2B |
0.801 | -0.106 | -2 | 0.715 |
PRP4 |
0.801 | -0.026 | -3 | 0.734 |
TAO3 |
0.801 | -0.011 | 1 | 0.790 |
CAMK1A |
0.801 | 0.099 | -3 | 0.625 |
CK1E |
0.801 | -0.037 | -3 | 0.513 |
PKG1 |
0.801 | 0.152 | -2 | 0.661 |
P38G |
0.801 | -0.022 | 1 | 0.459 |
TAO2 |
0.801 | 0.032 | 2 | 0.868 |
ERK7 |
0.801 | 0.080 | 2 | 0.627 |
CDK16 |
0.800 | 0.025 | 1 | 0.492 |
CDK2 |
0.800 | -0.069 | 1 | 0.637 |
ROCK1 |
0.800 | 0.249 | -3 | 0.739 |
GAK |
0.800 | 0.117 | 1 | 0.875 |
IRAK1 |
0.800 | -0.111 | -1 | 0.767 |
TLK1 |
0.800 | -0.110 | -2 | 0.722 |
PBK |
0.800 | 0.194 | 1 | 0.834 |
SBK |
0.799 | 0.107 | -3 | 0.548 |
LOK |
0.798 | 0.110 | -2 | 0.765 |
MEKK6 |
0.797 | 0.046 | 1 | 0.802 |
NEK4 |
0.797 | 0.016 | 1 | 0.813 |
CK1G1 |
0.797 | -0.042 | -3 | 0.499 |
TNIK |
0.797 | 0.101 | 3 | 0.838 |
NEK8 |
0.797 | -0.059 | 2 | 0.834 |
PDK1 |
0.797 | -0.018 | 1 | 0.802 |
HGK |
0.796 | 0.060 | 3 | 0.836 |
STK33 |
0.795 | 0.001 | 2 | 0.655 |
GRK2 |
0.795 | -0.129 | -2 | 0.649 |
CHK2 |
0.795 | 0.061 | -3 | 0.610 |
GCK |
0.795 | 0.039 | 1 | 0.797 |
LRRK2 |
0.795 | 0.056 | 2 | 0.854 |
CDK3 |
0.795 | -0.011 | 1 | 0.490 |
CK2A2 |
0.795 | 0.075 | 1 | 0.708 |
EEF2K |
0.794 | 0.016 | 3 | 0.826 |
HPK1 |
0.794 | 0.073 | 1 | 0.778 |
BMPR1A |
0.793 | -0.042 | 1 | 0.759 |
P38D |
0.793 | -0.019 | 1 | 0.495 |
NEK11 |
0.793 | -0.116 | 1 | 0.784 |
NEK1 |
0.793 | 0.050 | 1 | 0.824 |
KHS1 |
0.793 | 0.109 | 1 | 0.794 |
GSK3B |
0.793 | -0.040 | 4 | 0.378 |
CK1A2 |
0.792 | -0.027 | -3 | 0.460 |
MINK |
0.792 | 0.019 | 1 | 0.805 |
MAP3K15 |
0.792 | -0.022 | 1 | 0.767 |
CDK4 |
0.791 | 0.015 | 1 | 0.534 |
CRIK |
0.790 | 0.168 | -3 | 0.687 |
VRK1 |
0.790 | -0.034 | 2 | 0.846 |
KHS2 |
0.790 | 0.116 | 1 | 0.793 |
TAK1 |
0.790 | -0.044 | 1 | 0.831 |
GSK3A |
0.789 | -0.020 | 4 | 0.388 |
CDK6 |
0.789 | 0.005 | 1 | 0.563 |
CK1D |
0.789 | -0.051 | -3 | 0.461 |
HASPIN |
0.788 | 0.198 | -1 | 0.832 |
YSK1 |
0.788 | 0.063 | 2 | 0.815 |
JNK1 |
0.788 | -0.029 | 1 | 0.524 |
SLK |
0.787 | 0.001 | -2 | 0.703 |
MST2 |
0.787 | -0.096 | 1 | 0.817 |
CK2A1 |
0.786 | 0.064 | 1 | 0.680 |
PLK2 |
0.786 | -0.035 | -3 | 0.783 |
MST1 |
0.785 | -0.040 | 1 | 0.804 |
NEK3 |
0.783 | -0.003 | 1 | 0.781 |
GRK3 |
0.781 | -0.118 | -2 | 0.602 |
MEK2 |
0.780 | -0.154 | 2 | 0.801 |
BIKE |
0.779 | 0.146 | 1 | 0.787 |
PDHK3_TYR |
0.779 | 0.215 | 4 | 0.869 |
RIPK2 |
0.778 | -0.194 | 1 | 0.749 |
MYO3B |
0.778 | 0.083 | 2 | 0.825 |
YANK3 |
0.776 | 0.008 | 2 | 0.451 |
TAO1 |
0.772 | 0.009 | 1 | 0.739 |
PKMYT1_TYR |
0.771 | 0.094 | 3 | 0.853 |
LIMK2_TYR |
0.771 | 0.176 | -3 | 0.898 |
TESK1_TYR |
0.771 | 0.077 | 3 | 0.884 |
TTK |
0.770 | -0.036 | -2 | 0.730 |
ASK1 |
0.769 | -0.063 | 1 | 0.753 |
OSR1 |
0.769 | -0.076 | 2 | 0.801 |
MAP2K7_TYR |
0.768 | -0.025 | 2 | 0.861 |
MYO3A |
0.767 | -0.021 | 1 | 0.803 |
MAP2K4_TYR |
0.766 | -0.056 | -1 | 0.829 |
ALPHAK3 |
0.766 | -0.060 | -1 | 0.733 |
PDHK4_TYR |
0.766 | 0.016 | 2 | 0.882 |
PINK1_TYR |
0.766 | -0.000 | 1 | 0.830 |
EPHA6 |
0.766 | 0.077 | -1 | 0.786 |
LIMK1_TYR |
0.764 | 0.053 | 2 | 0.858 |
MAP2K6_TYR |
0.763 | -0.075 | -1 | 0.823 |
AAK1 |
0.762 | 0.162 | 1 | 0.691 |
DDR1 |
0.762 | 0.023 | 4 | 0.807 |
TNK2 |
0.761 | 0.090 | 3 | 0.750 |
RET |
0.761 | -0.008 | 1 | 0.810 |
EPHB4 |
0.760 | 0.001 | -1 | 0.780 |
BMPR2_TYR |
0.759 | -0.092 | -1 | 0.802 |
MST1R |
0.758 | -0.060 | 3 | 0.800 |
TYK2 |
0.758 | -0.093 | 1 | 0.821 |
PDHK1_TYR |
0.758 | -0.140 | -1 | 0.817 |
TNNI3K_TYR |
0.757 | 0.109 | 1 | 0.829 |
TNK1 |
0.756 | 0.108 | 3 | 0.767 |
TYRO3 |
0.755 | -0.085 | 3 | 0.784 |
ROS1 |
0.754 | -0.078 | 3 | 0.753 |
JAK2 |
0.752 | -0.135 | 1 | 0.804 |
EPHA4 |
0.752 | -0.021 | 2 | 0.795 |
ABL2 |
0.751 | -0.037 | -1 | 0.755 |
STLK3 |
0.750 | -0.173 | 1 | 0.753 |
WEE1_TYR |
0.749 | 0.029 | -1 | 0.757 |
YES1 |
0.749 | -0.049 | -1 | 0.786 |
CSF1R |
0.749 | -0.135 | 3 | 0.784 |
CK1A |
0.749 | -0.090 | -3 | 0.367 |
EPHB3 |
0.748 | -0.062 | -1 | 0.761 |
NEK10_TYR |
0.747 | -0.035 | 1 | 0.681 |
EPHB1 |
0.747 | -0.090 | 1 | 0.835 |
FER |
0.747 | -0.143 | 1 | 0.860 |
SRMS |
0.747 | -0.089 | 1 | 0.840 |
PDGFRB |
0.747 | -0.103 | 3 | 0.797 |
ABL1 |
0.747 | -0.059 | -1 | 0.750 |
TXK |
0.746 | -0.035 | 1 | 0.816 |
EPHB2 |
0.746 | -0.058 | -1 | 0.751 |
LTK |
0.746 | -0.027 | 3 | 0.750 |
JAK3 |
0.746 | -0.116 | 1 | 0.783 |
FGR |
0.745 | -0.112 | 1 | 0.856 |
AXL |
0.745 | -0.084 | 3 | 0.769 |
INSRR |
0.745 | -0.116 | 3 | 0.745 |
FGFR2 |
0.745 | -0.111 | 3 | 0.796 |
FLT3 |
0.745 | -0.116 | 3 | 0.782 |
JAK1 |
0.744 | -0.053 | 1 | 0.762 |
KDR |
0.744 | -0.063 | 3 | 0.754 |
ITK |
0.743 | -0.091 | -1 | 0.740 |
EPHA1 |
0.743 | -0.026 | 3 | 0.759 |
DDR2 |
0.743 | 0.070 | 3 | 0.733 |
HCK |
0.742 | -0.124 | -1 | 0.748 |
EPHA7 |
0.742 | -0.044 | 2 | 0.804 |
ALK |
0.742 | -0.075 | 3 | 0.718 |
MERTK |
0.742 | -0.082 | 3 | 0.780 |
TEK |
0.741 | -0.134 | 3 | 0.730 |
KIT |
0.741 | -0.150 | 3 | 0.794 |
EPHA3 |
0.741 | -0.086 | 2 | 0.778 |
YANK2 |
0.741 | -0.032 | 2 | 0.481 |
PDGFRA |
0.740 | -0.162 | 3 | 0.790 |
CK1G3 |
0.740 | -0.048 | -3 | 0.316 |
LCK |
0.739 | -0.065 | -1 | 0.746 |
BLK |
0.739 | -0.037 | -1 | 0.742 |
FGFR1 |
0.739 | -0.153 | 3 | 0.765 |
BTK |
0.738 | -0.165 | -1 | 0.720 |
TEC |
0.737 | -0.111 | -1 | 0.698 |
BMX |
0.737 | -0.081 | -1 | 0.685 |
PTK6 |
0.736 | -0.178 | -1 | 0.708 |
MET |
0.736 | -0.133 | 3 | 0.777 |
NTRK1 |
0.735 | -0.202 | -1 | 0.778 |
PTK2B |
0.734 | -0.061 | -1 | 0.745 |
EPHA5 |
0.734 | -0.065 | 2 | 0.791 |
FYN |
0.732 | -0.069 | -1 | 0.727 |
ERBB2 |
0.732 | -0.175 | 1 | 0.763 |
NTRK2 |
0.732 | -0.197 | 3 | 0.751 |
FLT1 |
0.732 | -0.145 | -1 | 0.741 |
FLT4 |
0.731 | -0.164 | 3 | 0.763 |
INSR |
0.731 | -0.160 | 3 | 0.716 |
LYN |
0.729 | -0.128 | 3 | 0.713 |
FRK |
0.728 | -0.164 | -1 | 0.744 |
FGFR3 |
0.728 | -0.188 | 3 | 0.770 |
NTRK3 |
0.728 | -0.161 | -1 | 0.739 |
CSK |
0.726 | -0.131 | 2 | 0.800 |
EPHA8 |
0.726 | -0.111 | -1 | 0.723 |
MATK |
0.725 | -0.122 | -1 | 0.704 |
SRC |
0.723 | -0.120 | -1 | 0.730 |
EGFR |
0.721 | -0.126 | 1 | 0.668 |
EPHA2 |
0.719 | -0.101 | -1 | 0.690 |
MUSK |
0.717 | -0.137 | 1 | 0.678 |
FGFR4 |
0.717 | -0.154 | -1 | 0.716 |
PTK2 |
0.716 | -0.093 | -1 | 0.690 |
IGF1R |
0.713 | -0.179 | 3 | 0.661 |
SYK |
0.710 | -0.133 | -1 | 0.678 |
CK1G2 |
0.709 | -0.082 | -3 | 0.413 |
ERBB4 |
0.706 | -0.131 | 1 | 0.682 |
FES |
0.700 | -0.180 | -1 | 0.677 |
ZAP70 |
0.685 | -0.128 | -1 | 0.642 |