Motif 954 (n=289)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5YKK6 | CNOT1 | S1061 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| A6NDE4 | RBMY1B | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member B | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| A6NEQ0 | RBMY1E | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member E | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| A8MTJ3 | GNAT3 | S206 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| O00116 | AGPS | S589 | ochoa | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
| O00267 | SUPT5H | S158 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00478 | BTN3A3 | S219 | ochoa | Butyrophilin subfamily 3 member A3 | Plays a role in T-cell responses in the adaptive immune response. {ECO:0000269|PubMed:22767497}. |
| O14530 | TXNDC9 | S182 | ochoa | Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4) | Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. {ECO:0000269|PubMed:16415341}. |
| O14686 | KMT2D | S3467 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14733 | MAP2K7 | S265 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14867 | BACH1 | S364 | ochoa | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}. |
| O14976 | GAK | S21 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15063 | GARRE1 | S574 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O43166 | SIPA1L1 | S1197 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43175 | PHGDH | S287 | ochoa | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O43491 | EPB41L2 | S950 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43524 | FOXO3 | S231 | psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O60242 | ADGRB3 | S1236 | ochoa | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) | Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:Q80ZF8, ECO:0000269|PubMed:24567399}. |
| O60716 | CTNND1 | S214 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60716 | CTNND1 | S269 | ochoa|psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75083 | WDR1 | S230 | ochoa | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}. |
| O75362 | ZNF217 | S441 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75494 | SRSF10 | S23 | ochoa | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}. |
| O95613 | PCNT | S644 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95613 | PCNT | S2485 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95747 | OXSR1 | S325 | ochoa|psp | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| O95873 | C6orf47 | S112 | ochoa | Uncharacterized protein C6orf47 (Protein G4) | None |
| O95983 | MBD3 | S56 | ochoa | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| O96017 | CHEK2 | S372 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P00558 | PGK1 | S399 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P02545 | LMNA | S525 | ochoa|psp | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P04035 | HMGCR | S420 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P04279 | SEMG1 | S156 | ochoa | Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein] | Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. {ECO:0000269|PubMed:19889947}.; FUNCTION: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. {ECO:0000269|PubMed:19889947}. |
| P04350 | TUBB4A | S95 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04406 | GAPDH | S192 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P04899 | GNAI2 | S207 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05060 | CHGB | S130 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P06400 | RB1 | S842 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P06733 | ENO1 | S141 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07205 | PGK2 | S399 | ochoa | Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific) | Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:P09041, ECO:0000269|PubMed:26677959}. |
| P07437 | TUBB | S95 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07550 | ADRB2 | S355 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P07814 | EPRS1 | S998 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08754 | GNAI3 | S206 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09874 | PARP1 | S75 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P09874 | PARP1 | S277 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0C7P1 | RBMY1D | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member D | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| P0DJD3 | RBMY1A1 | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}. |
| P0DJD4 | RBMY1C | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member C | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| P10398 | ARAF | S165 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P10451 | SPP1 | S27 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11171 | EPB41 | S812 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11488 | GNAT1 | S202 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}. |
| P13010 | XRCC5 | S191 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13929 | ENO3 | S176 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P15884 | TCF4 | S318 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P15924 | DSP | S38 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P17600 | SYN1 | S391 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P19087 | GNAT2 | S206 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| P19367 | HK1 | S88 | ochoa | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P19367 | HK1 | S89 | ochoa | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P21333 | FLNA | S440 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21554 | CNR1 | S429 | psp | Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) | G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712). {ECO:0000250|UniProtKB:O02777, ECO:0000250|UniProtKB:P47746, ECO:0000269|PubMed:15620723, ECO:0000269|PubMed:1718258, ECO:0000269|PubMed:17895407, ECO:0000269|PubMed:21895628, ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727}.; FUNCTION: [Isoform 1]: Binds both 2-arachidonoylglycerol (2-AG) and anandamide. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 2]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 3]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}. |
| P21796 | VDAC1 | S215 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P23284 | PPIB | S117 | ochoa | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}. |
| P23634 | ATP2B4 | S1115 | ochoa|psp | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P25101 | EDNRA | S404 | psp | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| P26639 | TARS1 | S110 | ochoa | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P27816 | MAP4 | S60 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28070 | PSMB4 | S99 | ochoa | Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) (Proteasome subunit beta-7) (beta-7) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P28799 | GRN | S81 | psp | Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] | Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12526812, PubMed:18378771, PubMed:28073925, PubMed:28453791, PubMed:28541286). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:12526812, ECO:0000269|PubMed:18378771, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286}.; FUNCTION: [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000269|PubMed:12526812}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000269|PubMed:28453791}. |
| P29317 | EPHA2 | S761 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29320 | EPHA3 | S768 | ochoa|psp | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| P29322 | EPHA8 | S782 | ochoa | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| P29323 | EPHB2 | S768 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P30305 | CDC25B | S160 | ochoa | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30533 | LRPAP1 | S247 | ochoa | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P31943 | HNRNPH1 | S281 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P35348 | ADRA1A | S246 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35637 | FUS | S26 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P36507 | MAP2K2 | S216 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P36873 | PPP1CC | S177 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
| P38398 | BRCA1 | S403 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40424 | PBX1 | S23 | ochoa | Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL) | Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786, PubMed:8327485). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250|UniProtKB:P41778, ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878, ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:8327485, ECO:0000269|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250|UniProtKB:P41778}. |
| P40425 | PBX2 | S101 | ochoa | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}. |
| P42704 | LRPPRC | S121 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P42765 | ACAA2 | S357 | ochoa | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312). {ECO:0000269|PubMed:18371312, ECO:0000269|PubMed:25478839, ECO:0000305|PubMed:25478839}. |
| P45985 | MAP2K4 | S251 | ochoa | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| P46777 | RPL5 | S172 | ochoa | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P48444 | ARCN1 | S223 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P49685 | GPR15 | S329 | ochoa | G-protein coupled receptor 15 (Brother of Bonzo) (BoB) | G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660). {ECO:0000250|UniProtKB:Q0VDU3, ECO:0000269|PubMed:33758080, ECO:0000269|PubMed:35510660, ECO:0000269|PubMed:38918398}.; FUNCTION: (Microbial infection) Acts as an alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9791028}. |
| P49790 | NUP153 | S246 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1450 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2845 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S3137 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49796 | RGS3 | S992 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P51825 | AFF1 | S172 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52630 | STAT2 | S393 | psp | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
| P52732 | KIF11 | S75 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P53367 | ARFIP1 | S44 | ochoa | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
| P53396 | ACLY | S667 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P54198 | HIRA | S112 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P54753 | EPHB3 | S780 | ochoa | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
| P54756 | EPHA5 | S822 | ochoa | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}. |
| P54760 | EPHB4 | S762 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P54762 | EPHB1 | S766 | ochoa | Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}. |
| P55082 | MFAP3 | S335 | ochoa | Microfibril-associated glycoprotein 3 | Component of the elastin-associated microfibrils. |
| P55795 | HNRNPH2 | S281 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P55795 | HNRNPH2 | S282 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P56211 | ARPP19 | S46 | psp | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P56470 | LGALS4 | S230 | ochoa | Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) | Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. |
| P57073 | SOX8 | S184 | ochoa | Transcription factor SOX-8 | Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250|UniProtKB:Q04886}. |
| P57789 | KCNK10 | S439 | ochoa | Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids (PubMed:10880510, PubMed:25766236, PubMed:26919430, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:30573346). In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+) (PubMed:26919430). {ECO:0000250|UniProtKB:Q8BUW1, ECO:0000269|PubMed:10880510, ECO:0000269|PubMed:25766236, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:38605031}. |
| P60201 | PLP1 | S114 | ochoa | Myelin proteolipid protein (PLP) (Lipophilin) | This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. |
| P62136 | PPP1CA | S177 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62140 | PPP1CB | S176 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| P62937 | PPIA | S77 | ochoa | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| P62995 | TRA2B | S216 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P63096 | GNAI1 | S206 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P68371 | TUBB4B | S95 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78368 | CSNK1G2 | S381 | ochoa | Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}. |
| P98175 | RBM10 | S842 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| P99999 | CYCS | S48 | ochoa | Cytochrome c | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
| Q00872 | MYBPC1 | S422 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q00987 | MDM2 | S121 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q02750 | MAP2K1 | S212 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| Q05397 | PTK2 | S568 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q06187 | BTK | S543 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08345 | DDR1 | S788 | psp | Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) | Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:19401332, ECO:0000269|PubMed:20093046, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:20884741, ECO:0000269|PubMed:21044884, ECO:0000269|PubMed:9659899}. |
| Q09666 | AHNAK | S5190 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12864 | CDH17 | S358 | ochoa | Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin) | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269|PubMed:8153632}. |
| Q13131 | PRKAA1 | S172 | psp | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13523 | PRP4K | S623 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13761 | RUNX3 | S149 | psp | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13835 | PKP1 | S229 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q13885 | TUBB2A | S95 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q13950 | RUNX2 | S196 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q13976 | PRKG1 | S65 | psp | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| Q14126 | DSG2 | S999 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14156 | EFR3A | S415 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14190 | SIM2 | S115 | psp | Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15) | Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. |
| Q14289 | PTK2B | S571 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14315 | FLNC | S2646 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14320 | FAM50A | S276 | ochoa | Protein FAM50A (Protein HXC-26) (Protein XAP-5) | Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}. |
| Q14573 | ITPR3 | S946 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14669 | TRIP12 | S1248 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14699 | RFTN1 | S555 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14956 | GPNMB | S542 | psp | Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type) | Could be a melanogenic enzyme. {ECO:0000250}. |
| Q14966 | ZNF638 | S278 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15052 | ARHGEF6 | S679 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15274 | QPRT | S42 | ochoa | Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase) | Involved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671, ECO:0000269|PubMed:9473669}. |
| Q15375 | EPHA7 | S780 | ochoa | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
| Q15415 | RBMY1F | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2) | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269|PubMed:8269511}. |
| Q15942 | ZYX | S481 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16513 | PKN2 | S19 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16566 | CAMK4 | S189 | ochoa | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| Q16851 | UGP2 | S120 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Q2M1Z3 | ARHGAP31 | S388 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q53HL2 | CDCA8 | S238 | psp | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
| Q5T447 | HECTD3 | S59 | psp | E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) | E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}. |
| Q5T7B8 | KIF24 | S957 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5VU65 | NUP210L | S523 | ochoa | Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like) | None |
| Q5VUA4 | ZNF318 | S508 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VZ89 | DENND4C | S1659 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6KC79 | NIPBL | S2682 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6PFW1 | PPIP5K1 | S1036 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6PIW4 | FIGNL1 | S157 | ochoa | Fidgetin-like protein 1 (EC 3.6.4.-) | Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376}. |
| Q6PJF5 | RHBDF2 | S129 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6UX15 | LAYN | S286 | ochoa | Layilin | Receptor for hyaluronate. {ECO:0000269|PubMed:11294894}. |
| Q6W4X9 | MUC6 | S936 | ochoa | Mucin-6 (MUC-6) (Gastric mucin-6) | May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}. |
| Q6WKZ4 | RAB11FIP1 | S300 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q709C8 | VPS13C | S3516 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q7Z2D5 | PLPPR4 | S365 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z2W4 | ZC3HAV1 | S322 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z6E9 | RBBP6 | S1262 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6L1 | TECPR1 | S409 | ochoa | Tectonin beta-propeller repeat-containing protein 1 | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
| Q86UR5 | RIMS1 | S1311 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86V48 | LUZP1 | S440 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VS8 | HOOK3 | S693 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q8IUD2 | ERC1 | S94 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8N165 | PDIK1L | S194 | ochoa|psp | Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like) | None |
| Q8N3D4 | EHBP1L1 | S661 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3E9 | PLCD3 | S573 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}. |
| Q8N3S3 | PHTF2 | S222 | ochoa | Protein PHTF2 | None |
| Q8N4C8 | MINK1 | S175 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4N8 | KIF2B | S617 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8NFA0 | USP32 | S1454 | ochoa | Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) | Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}. |
| Q8TAD8 | SNIP1 | S200 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TBE0 | BAHD1 | S180 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TDM6 | DLG5 | S296 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDR2 | STK35 | S385 | ochoa|psp | Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1) | None |
| Q8TDW5 | SYTL5 | S294 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8WW12 | PCNP | S156 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q92613 | JADE3 | S650 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92888 | ARHGEF1 | S266 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q92934 | BAD | S32 | ochoa | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q969K3 | RNF34 | S268 | ochoa | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}. |
| Q96CC6 | RHBDF1 | S92 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96CP6 | GRAMD1A | S415 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96FI4 | NEIL1 | S269 | psp | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}. |
| Q96KQ7 | EHMT2 | S237 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96ST8 | CEP89 | S153 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q96T17 | MAP7D2 | S634 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q99081 | TCF12 | S333 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99661 | KIF2C | S22 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99959 | PKP2 | S329 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BV86 | NTMT1 | S63 | ochoa | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed] | Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:26543159}. |
| Q9BVA1 | TUBB2B | S95 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BXS6 | NUSAP1 | S333 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9C0B1 | FTO | S184 | ochoa | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9C0C2 | TNKS1BP1 | S1182 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1248 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1331 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZY0 | NXF2 | S289 | ochoa | Nuclear RNA export factor 2 (Cancer/testis antigen 39) (CT39) (TAP-like protein 2) (TAPL-2) | Involved in the export of mRNA from the nucleus to the cytoplasm. |
| Q9H1B4 | NXF5 | S178 | ochoa | Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1) | Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons. |
| Q9H2G2 | SLK | S177 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H4A6 | GOLPH3 | S36 | ochoa | Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) | Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}. |
| Q9H4B7 | TUBB1 | S95 | ochoa | Tubulin beta-1 chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H4G0 | EPB41L1 | S820 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4L5 | OSBPL3 | S765 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H8H3 | TMT1A | S69 | ochoa | Thiol S-methyltransferase TMT1A (EC 2.1.1.9) (Methyltransferase-like protein 7A) (N6-adenosine-methyltransferase TMT1A) (EC 2.1.1.348) (Protein AAM-B) (Thiol methyltransferase 1A) | Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358). {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:34980213, ECO:0000269|PubMed:37137720}.; FUNCTION: (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. {ECO:0000269|PubMed:26185986}. |
| Q9HCK8 | CHD8 | S284 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCP0 | CSNK1G1 | S32 | ochoa | Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}. |
| Q9NPG1 | FZD3 | S557 | ochoa | Frizzled-3 (Fz-3) (hFz3) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q61086}. |
| Q9NSK0 | KLC4 | S513 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NUQ8 | ABCF3 | S83 | ochoa | ATP-binding cassette sub-family F member 3 | Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}. |
| Q9NV96 | TMEM30A | S147 | ochoa | Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A) | Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:21289302, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:32493773}. |
| Q9NYL9 | TMOD3 | S156 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NYQ6 | CELSR1 | S2758 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NYV4 | CDK12 | S30 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZ56 | FMN2 | S499 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9P212 | PLCE1 | S1689 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9P241 | ATP10D | S521 | ochoa | Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}. |
| Q9UBY0 | SLC9A2 | S693 | ochoa | Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). {ECO:0000250|UniProtKB:Q3ZAS0, ECO:0000269|PubMed:10444453}. |
| Q9UEW8 | STK39 | S371 | ochoa|psp | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UF33 | EPHA6 | S820 | ochoa | Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}. |
| Q9UGL1 | KDM5B | S1312 | ochoa | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
| Q9UHL9 | GTF2IRD1 | S113 | ochoa | General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. |
| Q9UHQ9 | CYB5R1 | S150 | ochoa | NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) | NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}. |
| Q9UKE5 | TNIK | S175 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UMS5 | PHTF1 | S272 | ochoa | Protein PHTF1 | None |
| Q9UMZ2 | SYNRG | S822 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UMZ2 | SYNRG | S936 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPU9 | SAMD4A | S578 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9Y2B0 | CNPY2 | S115 | ochoa | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| Q9Y2J2 | EPB41L3 | S1031 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2S7 | POLDIP2 | S290 | ochoa | Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38) | Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). {ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:26984527}. |
| Q9Y2W1 | THRAP3 | S559 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4F1 | FARP1 | S613 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y572 | RIPK3 | S164 | psp | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y6M4 | CSNK1G3 | S413 | ochoa | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
| P07814 | EPRS1 | S335 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P60174 | TPI1 | S106 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| Q9BRA2 | TXNDC17 | S41 | Sugiyama | Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) | Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. {ECO:0000269|PubMed:14607843, ECO:0000269|PubMed:14607844}. |
| O14965 | AURKA | S278 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| P11279 | LAMP1 | S335 | Sugiyama | Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:7685349}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:25972533, ECO:0000269|PubMed:27605678, ECO:0000269|PubMed:28448640, ECO:0000269|PubMed:29295909}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}. |
| P11047 | LAMC1 | S348 | Sugiyama | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P15735 | PHKG2 | S175 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| P29144 | TPP2 | S93 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| P60174 | TPI1 | S97 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P11717 | IGF2R | S1378 | Sugiyama | Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}. |
| P62873 | GNB1 | S207 | Sugiyama | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:37991948, PubMed:38168118, PubMed:38552625). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). {ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:35835867, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:38168118, ECO:0000269|PubMed:38552625}. |
| Q9UP83 | COG5 | S66 | Sugiyama | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}. |
| P17844 | DDX5 | S519 | Sugiyama | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| Q04726 | TLE3 | S622 | Sugiyama | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q04760 | GLO1 | S120 | Sugiyama | Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CPU0, ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:20454679, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}. |
| O75663 | TIPRL | S124 | Sugiyama | TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP) | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681, ECO:0000269|PubMed:26717153}. |
| Q92997 | DVL3 | S263 | GPS6 | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| P78368 | CSNK1G2 | S26 | Sugiyama | Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}. |
| Q12778 | FOXO1 | S234 | PSP | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q13043 | STK4 | S288 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| P04040 | CAT | S120 | Sugiyama | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
| O75688 | PPM1B | S186 | Sugiyama | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| P35813 | PPM1A | S181 | Sugiyama | Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}. |
| Q16816 | PHKG1 | S172 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q16816 | PHKG1 | S58 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q6P2M8 | PNCK | S323 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). {ECO:0000250}. |
| Q86UE8 | TLK2 | S307 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| P10586 | PTPRF | S1853 | Sugiyama | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| P23468 | PTPRD | S1858 | Sugiyama | Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) | Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. {ECO:0000250|UniProtKB:Q64487}. |
| Q13332 | PTPRS | S1894 | Sugiyama | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) | Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as a tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). {ECO:0000250|UniProtKB:B0V2N1, ECO:0000250|UniProtKB:F1NWE3, ECO:0000269|PubMed:21454754, ECO:0000269|PubMed:26231120, ECO:0000269|PubMed:8524829}. |
| O60271 | SPAG9 | S710 | Sugiyama | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| P30876 | POLR2B | S467 | Sugiyama | DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:27193682, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the largest subunit POLR2A/RPB1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). {ECO:0000250|UniProtKB:A5PJW8, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}. |
| Q6EMK4 | VASN | S488 | Sugiyama | Vasorin (Protein slit-like 2) | May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}. |
| Q8N568 | DCLK2 | S174 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q9Y2I7 | PIKFYVE | S1145 | Sugiyama | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9P227 | ARHGAP23 | S127 | EPSD|PSP | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P27540 | ARNT | S57 | Sugiyama | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}. |
| P62879 | GNB2 | S207 | Sugiyama | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.984381e-07 | 6.702 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.187470e-06 | 5.925 |
| R-HSA-983189 | Kinesins | 1.324807e-06 | 5.878 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 6.184834e-06 | 5.209 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 5.970470e-06 | 5.224 |
| R-HSA-112316 | Neuronal System | 5.750982e-06 | 5.240 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 7.668704e-06 | 5.115 |
| R-HSA-162582 | Signal Transduction | 8.059243e-06 | 5.094 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.155246e-05 | 4.937 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 1.523549e-05 | 4.817 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.905356e-05 | 4.720 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.511851e-05 | 4.454 |
| R-HSA-9646399 | Aggrephagy | 4.805576e-05 | 4.318 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 5.680549e-05 | 4.246 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.208169e-05 | 4.036 |
| R-HSA-3928664 | Ephrin signaling | 1.046074e-04 | 3.980 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.403389e-04 | 3.853 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.537401e-04 | 3.813 |
| R-HSA-392518 | Signal amplification | 1.833752e-04 | 3.737 |
| R-HSA-68886 | M Phase | 1.737114e-04 | 3.760 |
| R-HSA-190861 | Gap junction assembly | 1.833752e-04 | 3.737 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.879717e-04 | 3.726 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.025791e-04 | 3.693 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.029997e-04 | 3.519 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.108829e-04 | 3.507 |
| R-HSA-1640170 | Cell Cycle | 2.927349e-04 | 3.534 |
| R-HSA-68882 | Mitotic Anaphase | 2.923532e-04 | 3.534 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.048567e-04 | 3.516 |
| R-HSA-373760 | L1CAM interactions | 2.994745e-04 | 3.524 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.533114e-04 | 3.452 |
| R-HSA-68877 | Mitotic Prometaphase | 3.508898e-04 | 3.455 |
| R-HSA-70171 | Glycolysis | 4.096081e-04 | 3.388 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.065133e-04 | 3.391 |
| R-HSA-9675108 | Nervous system development | 4.259046e-04 | 3.371 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.491919e-04 | 3.348 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.743895e-04 | 3.324 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.691378e-04 | 3.329 |
| R-HSA-991365 | Activation of GABAB receptors | 5.210639e-04 | 3.283 |
| R-HSA-977444 | GABA B receptor activation | 5.210639e-04 | 3.283 |
| R-HSA-111885 | Opioid Signalling | 5.265432e-04 | 3.279 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.337846e-04 | 3.273 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 5.895029e-04 | 3.230 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 5.895029e-04 | 3.230 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.818185e-04 | 3.235 |
| R-HSA-190828 | Gap junction trafficking | 6.382526e-04 | 3.195 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 7.040157e-04 | 3.152 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.134114e-04 | 3.147 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.622477e-04 | 3.118 |
| R-HSA-9663891 | Selective autophagy | 7.622477e-04 | 3.118 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 8.511774e-04 | 3.070 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 9.022864e-04 | 3.045 |
| R-HSA-9634597 | GPER1 signaling | 9.331133e-04 | 3.030 |
| R-HSA-69275 | G2/M Transition | 8.734931e-04 | 3.059 |
| R-HSA-422475 | Axon guidance | 9.377647e-04 | 3.028 |
| R-HSA-70263 | Gluconeogenesis | 9.331133e-04 | 3.030 |
| R-HSA-437239 | Recycling pathway of L1 | 8.511774e-04 | 3.070 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.483382e-04 | 3.023 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 1.012100e-03 | 2.995 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.014796e-03 | 2.994 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.020987e-03 | 2.991 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 1.079045e-03 | 2.967 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.079045e-03 | 2.967 |
| R-HSA-4086398 | Ca2+ pathway | 1.236951e-03 | 2.908 |
| R-HSA-70326 | Glucose metabolism | 1.298929e-03 | 2.886 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.415627e-03 | 2.849 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.415627e-03 | 2.849 |
| R-HSA-390696 | Adrenoceptors | 1.415627e-03 | 2.849 |
| R-HSA-5673000 | RAF activation | 1.415061e-03 | 2.849 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.414515e-03 | 2.849 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.415627e-03 | 2.849 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.500112e-03 | 2.824 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 1.661498e-03 | 2.780 |
| R-HSA-418597 | G alpha (z) signalling events | 1.689110e-03 | 2.772 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.689110e-03 | 2.772 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.732794e-03 | 2.761 |
| R-HSA-195721 | Signaling by WNT | 1.803416e-03 | 2.744 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.875661e-03 | 2.727 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.812834e-03 | 2.742 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.980695e-03 | 2.703 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.414806e-03 | 2.617 |
| R-HSA-977443 | GABA receptor activation | 2.463829e-03 | 2.608 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.703747e-03 | 2.568 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.671468e-03 | 2.573 |
| R-HSA-9612973 | Autophagy | 2.620686e-03 | 2.582 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.746332e-03 | 2.561 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.074595e-03 | 2.512 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.176289e-03 | 2.498 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.631569e-03 | 2.440 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.668146e-03 | 2.436 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 3.890041e-03 | 2.410 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.904632e-03 | 2.408 |
| R-HSA-112040 | G-protein mediated events | 3.962391e-03 | 2.402 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 4.053956e-03 | 2.392 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.221696e-03 | 2.375 |
| R-HSA-391251 | Protein folding | 4.401362e-03 | 2.356 |
| R-HSA-1632852 | Macroautophagy | 4.461331e-03 | 2.351 |
| R-HSA-75153 | Apoptotic execution phase | 4.569695e-03 | 2.340 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.977245e-03 | 2.303 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.074949e-03 | 2.295 |
| R-HSA-72172 | mRNA Splicing | 5.296428e-03 | 2.276 |
| R-HSA-5620924 | Intraflagellar transport | 5.311627e-03 | 2.275 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.953862e-03 | 2.225 |
| R-HSA-8939211 | ESR-mediated signaling | 5.412398e-03 | 2.267 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.709994e-03 | 2.243 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.017102e-03 | 2.221 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 6.393576e-03 | 2.194 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 6.393576e-03 | 2.194 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 6.393576e-03 | 2.194 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 6.502837e-03 | 2.187 |
| R-HSA-2559583 | Cellular Senescence | 6.583699e-03 | 2.182 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 7.476853e-03 | 2.126 |
| R-HSA-397795 | G-protein beta:gamma signalling | 7.718903e-03 | 2.112 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.549307e-03 | 2.122 |
| R-HSA-6794361 | Neurexins and neuroligins | 7.044077e-03 | 2.152 |
| R-HSA-1266738 | Developmental Biology | 7.056470e-03 | 2.151 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.533285e-03 | 2.123 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.258627e-03 | 2.083 |
| R-HSA-9833482 | PKR-mediated signaling | 8.392838e-03 | 2.076 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 8.532569e-03 | 2.069 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 8.591128e-03 | 2.066 |
| R-HSA-5617833 | Cilium Assembly | 9.087757e-03 | 2.042 |
| R-HSA-109582 | Hemostasis | 9.523537e-03 | 2.021 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.027939e-02 | 1.988 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.032917e-02 | 1.986 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.073876e-02 | 1.969 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.159708e-02 | 1.936 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.107786e-02 | 1.956 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.089458e-02 | 1.963 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.187911e-02 | 1.925 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.089458e-02 | 1.963 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.344307e-02 | 1.872 |
| R-HSA-2262752 | Cellular responses to stress | 1.399668e-02 | 1.854 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.427460e-02 | 1.845 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.533267e-02 | 1.814 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.546607e-02 | 1.811 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.615897e-02 | 1.792 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.654553e-02 | 1.781 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.664962e-02 | 1.779 |
| R-HSA-9616334 | Defective Base Excision Repair Associated with NEIL1 | 1.943298e-02 | 1.711 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.943298e-02 | 1.711 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.687124e-02 | 1.773 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.687124e-02 | 1.773 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.817651e-02 | 1.740 |
| R-HSA-1500931 | Cell-Cell communication | 1.668101e-02 | 1.778 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.734801e-02 | 1.761 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.830732e-02 | 1.737 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.958471e-02 | 1.708 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 2.015495e-02 | 1.696 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 2.015495e-02 | 1.696 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.188814e-02 | 1.660 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.188814e-02 | 1.660 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.343771e-02 | 1.630 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 2.368195e-02 | 1.626 |
| R-HSA-525793 | Myogenesis | 2.582352e-02 | 1.588 |
| R-HSA-109581 | Apoptosis | 2.723070e-02 | 1.565 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.792397e-02 | 1.554 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.792397e-02 | 1.554 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 2.792397e-02 | 1.554 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.011263e-02 | 1.521 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 3.142358e-02 | 1.503 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 3.142358e-02 | 1.503 |
| R-HSA-418555 | G alpha (s) signalling events | 3.566086e-02 | 1.448 |
| R-HSA-162592 | Integration of provirus | 3.561789e-02 | 1.448 |
| R-HSA-5357801 | Programmed Cell Death | 3.537529e-02 | 1.451 |
| R-HSA-163685 | Integration of energy metabolism | 3.290985e-02 | 1.483 |
| R-HSA-446728 | Cell junction organization | 3.521867e-02 | 1.453 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.739970e-02 | 1.427 |
| R-HSA-9658195 | Leishmania infection | 3.739970e-02 | 1.427 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 3.142358e-02 | 1.503 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.155845e-02 | 1.501 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.747771e-02 | 1.426 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 3.753685e-02 | 1.426 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 3.753685e-02 | 1.426 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.848949e-02 | 1.415 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.848949e-02 | 1.415 |
| R-HSA-5663205 | Infectious disease | 3.915306e-02 | 1.407 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.924055e-02 | 1.406 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.924055e-02 | 1.406 |
| R-HSA-4641265 | Repression of WNT target genes | 4.001485e-02 | 1.398 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 4.460503e-02 | 1.351 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.830017e-02 | 1.316 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 4.786127e-02 | 1.320 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.507022e-02 | 1.346 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.236306e-02 | 1.373 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 4.001485e-02 | 1.398 |
| R-HSA-418594 | G alpha (i) signalling events | 4.522362e-02 | 1.345 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.035658e-02 | 1.394 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.994589e-02 | 1.302 |
| R-HSA-170968 | Frs2-mediated activation | 4.460503e-02 | 1.351 |
| R-HSA-372790 | Signaling by GPCR | 4.147604e-02 | 1.382 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 4.001485e-02 | 1.398 |
| R-HSA-391160 | Signal regulatory protein family interactions | 4.937932e-02 | 1.306 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.507022e-02 | 1.346 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 4.937932e-02 | 1.306 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 4.937932e-02 | 1.306 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 4.460503e-02 | 1.351 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 4.937932e-02 | 1.306 |
| R-HSA-68875 | Mitotic Prophase | 5.049382e-02 | 1.297 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.257293e-02 | 1.279 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.257293e-02 | 1.279 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.369133e-02 | 1.270 |
| R-HSA-163560 | Triglyceride catabolism | 5.369133e-02 | 1.270 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.502205e-02 | 1.259 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.672833e-02 | 1.246 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 5.717680e-02 | 1.243 |
| R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | 5.717680e-02 | 1.243 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 5.717680e-02 | 1.243 |
| R-HSA-9708530 | Regulation of BACH1 activity | 5.944515e-02 | 1.226 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 5.944515e-02 | 1.226 |
| R-HSA-169893 | Prolonged ERK activation events | 5.944515e-02 | 1.226 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 7.550205e-02 | 1.122 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 7.550205e-02 | 1.122 |
| R-HSA-1299503 | TWIK related potassium channel (TREK) | 7.550205e-02 | 1.122 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 7.571244e-02 | 1.121 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 8.141504e-02 | 1.089 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 8.141504e-02 | 1.089 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 6.631410e-02 | 1.178 |
| R-HSA-5674135 | MAP2K and MAPK activation | 7.308838e-02 | 1.136 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.688910e-02 | 1.114 |
| R-HSA-380287 | Centrosome maturation | 8.232656e-02 | 1.084 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 7.571244e-02 | 1.121 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 7.308838e-02 | 1.136 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 7.571244e-02 | 1.121 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 8.141504e-02 | 1.089 |
| R-HSA-69541 | Stabilization of p53 | 6.304087e-02 | 1.200 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.949286e-02 | 1.158 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 7.571244e-02 | 1.121 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 7.571244e-02 | 1.121 |
| R-HSA-388396 | GPCR downstream signalling | 6.820547e-02 | 1.166 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 7.658687e-02 | 1.116 |
| R-HSA-422356 | Regulation of insulin secretion | 6.541271e-02 | 1.184 |
| R-HSA-212436 | Generic Transcription Pathway | 7.747350e-02 | 1.111 |
| R-HSA-9675151 | Disorders of Developmental Biology | 6.471982e-02 | 1.189 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 7.571244e-02 | 1.121 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 7.308838e-02 | 1.136 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 6.304087e-02 | 1.200 |
| R-HSA-9609690 | HCMV Early Events | 6.396376e-02 | 1.194 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.304087e-02 | 1.200 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 7.658687e-02 | 1.116 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.238059e-02 | 1.140 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.770399e-02 | 1.110 |
| R-HSA-8982491 | Glycogen metabolism | 6.631410e-02 | 1.178 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 7.014485e-02 | 1.154 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 8.141504e-02 | 1.089 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.342449e-02 | 1.198 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.368229e-02 | 1.196 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 8.015783e-02 | 1.096 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 6.304087e-02 | 1.200 |
| R-HSA-375280 | Amine ligand-binding receptors | 8.379990e-02 | 1.077 |
| R-HSA-418346 | Platelet homeostasis | 8.485072e-02 | 1.071 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.719475e-02 | 1.060 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 8.724535e-02 | 1.059 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 8.724535e-02 | 1.059 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.724535e-02 | 1.059 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.724535e-02 | 1.059 |
| R-HSA-445144 | Signal transduction by L1 | 8.724535e-02 | 1.059 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 9.347222e-02 | 1.029 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 9.347222e-02 | 1.029 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 9.347222e-02 | 1.029 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 1.110942e-01 | 0.954 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 1.110942e-01 | 0.954 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 1.283746e-01 | 0.892 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.453202e-01 | 0.838 |
| R-HSA-164525 | Plus-strand DNA synthesis | 1.453202e-01 | 0.838 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.453202e-01 | 0.838 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.453202e-01 | 0.838 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.619374e-01 | 0.791 |
| R-HSA-162585 | Uncoating of the HIV Virion | 1.619374e-01 | 0.791 |
| R-HSA-162589 | Reverse Transcription of HIV RNA | 1.942116e-01 | 0.712 |
| R-HSA-164516 | Minus-strand DNA synthesis | 1.942116e-01 | 0.712 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 2.098811e-01 | 0.678 |
| R-HSA-201688 | WNT mediated activation of DVL | 2.098811e-01 | 0.678 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 2.098811e-01 | 0.678 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.098811e-01 | 0.678 |
| R-HSA-173107 | Binding and entry of HIV virion | 2.252468e-01 | 0.647 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 2.252468e-01 | 0.647 |
| R-HSA-164843 | 2-LTR circle formation | 2.252468e-01 | 0.647 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.054328e-01 | 0.977 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.117054e-01 | 0.952 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.117054e-01 | 0.952 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 1.245280e-01 | 0.905 |
| R-HSA-1296059 | G protein gated Potassium channels | 1.245280e-01 | 0.905 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 1.245280e-01 | 0.905 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.245280e-01 | 0.905 |
| R-HSA-8874081 | MET activates PTK2 signaling | 1.310662e-01 | 0.883 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.695795e-01 | 0.569 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.376815e-01 | 0.861 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.376815e-01 | 0.861 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.443684e-01 | 0.841 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.443684e-01 | 0.841 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.443684e-01 | 0.841 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.443684e-01 | 0.841 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.511216e-01 | 0.821 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.579361e-01 | 0.802 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.648070e-01 | 0.783 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.648070e-01 | 0.783 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.786991e-01 | 0.748 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.786991e-01 | 0.748 |
| R-HSA-390522 | Striated Muscle Contraction | 1.857113e-01 | 0.731 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.857113e-01 | 0.731 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.195421e-01 | 0.922 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.998466e-01 | 0.699 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.284504e-01 | 0.641 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.356495e-01 | 0.628 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.356495e-01 | 0.628 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.136683e-01 | 0.670 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.601515e-01 | 0.585 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.231657e-01 | 0.910 |
| R-HSA-167169 | HIV Transcription Elongation | 2.356495e-01 | 0.628 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 9.926099e-02 | 1.003 |
| R-HSA-72086 | mRNA Capping | 1.511216e-01 | 0.821 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.356495e-01 | 0.628 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.720098e-01 | 0.764 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 2.550903e-01 | 0.593 |
| R-HSA-202040 | G-protein activation | 9.319629e-02 | 1.031 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.550903e-01 | 0.593 |
| R-HSA-111458 | Formation of apoptosome | 2.252468e-01 | 0.647 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.252468e-01 | 0.647 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.403146e-01 | 0.619 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.284504e-01 | 0.641 |
| R-HSA-6798695 | Neutrophil degranulation | 9.141401e-02 | 1.039 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.927618e-01 | 0.715 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 9.319629e-02 | 1.031 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 1.110942e-01 | 0.954 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 1.180724e-01 | 0.928 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.695795e-01 | 0.569 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.129179e-02 | 1.040 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.129179e-02 | 1.040 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.129179e-02 | 1.040 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.579361e-01 | 0.802 |
| R-HSA-162587 | HIV Life Cycle | 1.327050e-01 | 0.877 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.369583e-01 | 0.863 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.619374e-01 | 0.791 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 9.319629e-02 | 1.031 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 2.252468e-01 | 0.647 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 2.550903e-01 | 0.593 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.550903e-01 | 0.593 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.786991e-01 | 0.748 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.998466e-01 | 0.699 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.079905e-01 | 0.682 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.927618e-01 | 0.715 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.837948e-01 | 0.736 |
| R-HSA-5693538 | Homology Directed Repair | 2.615264e-01 | 0.582 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.153250e-01 | 0.938 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 1.110942e-01 | 0.954 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.942116e-01 | 0.712 |
| R-HSA-9766229 | Degradation of CDH1 | 1.030275e-01 | 0.987 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.054328e-01 | 0.977 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.376815e-01 | 0.861 |
| R-HSA-4641258 | Degradation of DVL | 2.141030e-01 | 0.669 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.129179e-02 | 1.040 |
| R-HSA-162906 | HIV Infection | 2.145432e-01 | 0.668 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.782324e-01 | 0.749 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 2.098811e-01 | 0.678 |
| R-HSA-177135 | Conjugation of benzoate with glycine | 2.403146e-01 | 0.619 |
| R-HSA-192814 | vRNA Synthesis | 2.403146e-01 | 0.619 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 1.117054e-01 | 0.952 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.550903e-01 | 0.593 |
| R-HSA-75896 | Plasmalogen biosynthesis | 2.550903e-01 | 0.593 |
| R-HSA-177128 | Conjugation of salicylate with glycine | 2.695795e-01 | 0.569 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.927618e-01 | 0.715 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.141030e-01 | 0.669 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.551773e-01 | 0.809 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.356495e-01 | 0.628 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.187471e-01 | 0.660 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.228236e-01 | 0.911 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.573083e-01 | 0.590 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.252468e-01 | 0.647 |
| R-HSA-4086400 | PCP/CE pathway | 2.392952e-01 | 0.621 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.782324e-01 | 0.749 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 1.180724e-01 | 0.928 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 1.717295e-01 | 0.765 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.542598e-01 | 0.595 |
| R-HSA-8875878 | MET promotes cell motility | 2.212671e-01 | 0.655 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.030275e-01 | 0.987 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.030275e-01 | 0.987 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.453202e-01 | 0.838 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.942116e-01 | 0.712 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 2.252468e-01 | 0.647 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.054328e-01 | 0.977 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.857113e-01 | 0.731 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.212671e-01 | 0.655 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.086157e-01 | 0.681 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 1.579361e-01 | 0.802 |
| R-HSA-416476 | G alpha (q) signalling events | 1.980234e-01 | 0.703 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.869166e-01 | 0.728 |
| R-HSA-114608 | Platelet degranulation | 1.494024e-01 | 0.826 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.883196e-01 | 0.725 |
| R-HSA-9675135 | Diseases of DNA repair | 9.129179e-02 | 1.040 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.985946e-01 | 0.702 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.110942e-01 | 0.954 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 1.283746e-01 | 0.892 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.782324e-01 | 0.749 |
| R-HSA-2025928 | Calcineurin activates NFAT | 2.098811e-01 | 0.678 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 2.550903e-01 | 0.593 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.645569e-01 | 0.784 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.428609e-01 | 0.615 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.253274e-01 | 0.902 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.927618e-01 | 0.715 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.998466e-01 | 0.699 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.325251e-01 | 0.878 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.886952e-01 | 0.724 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.712990e-01 | 0.766 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.122582e-01 | 0.950 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 1.453202e-01 | 0.838 |
| R-HSA-194138 | Signaling by VEGF | 1.433780e-01 | 0.844 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 1.110942e-01 | 0.954 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 1.283746e-01 | 0.892 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 1.453202e-01 | 0.838 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.942116e-01 | 0.712 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.117054e-01 | 0.952 |
| R-HSA-429947 | Deadenylation of mRNA | 1.180724e-01 | 0.928 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.550903e-01 | 0.593 |
| R-HSA-9839394 | TGFBR3 expression | 1.245280e-01 | 0.905 |
| R-HSA-446205 | Synthesis of GDP-mannose | 2.695795e-01 | 0.569 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.511216e-01 | 0.821 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.648070e-01 | 0.783 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.122018e-01 | 0.950 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.356495e-01 | 0.628 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.356495e-01 | 0.628 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.428609e-01 | 0.615 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.035907e-01 | 0.691 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.035907e-01 | 0.691 |
| R-HSA-8953854 | Metabolism of RNA | 1.749099e-01 | 0.757 |
| R-HSA-199991 | Membrane Trafficking | 2.442227e-01 | 0.612 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.658099e-01 | 0.575 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.998466e-01 | 0.699 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.428609e-01 | 0.615 |
| R-HSA-9659379 | Sensory processing of sound | 2.444837e-01 | 0.612 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.658099e-01 | 0.575 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.428609e-01 | 0.615 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.403146e-01 | 0.619 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.998466e-01 | 0.699 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.491146e-01 | 0.604 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.453202e-01 | 0.838 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.453202e-01 | 0.838 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.453202e-01 | 0.838 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.695795e-01 | 0.569 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.695795e-01 | 0.569 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.695795e-01 | 0.569 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.212671e-01 | 0.655 |
| R-HSA-913531 | Interferon Signaling | 1.744480e-01 | 0.758 |
| R-HSA-418990 | Adherens junctions interactions | 1.900421e-01 | 0.721 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.496902e-01 | 0.603 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 1.245280e-01 | 0.905 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.786188e-01 | 0.748 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.786188e-01 | 0.748 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.290067e-01 | 0.640 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.913774e-01 | 0.718 |
| R-HSA-165159 | MTOR signalling | 2.573083e-01 | 0.590 |
| R-HSA-1483249 | Inositol phosphate metabolism | 9.931788e-02 | 1.003 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 2.252468e-01 | 0.647 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 1.443684e-01 | 0.841 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 1.857113e-01 | 0.731 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.284504e-01 | 0.641 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.573083e-01 | 0.590 |
| R-HSA-9824446 | Viral Infection Pathways | 2.521035e-01 | 0.598 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.043995e-01 | 0.981 |
| R-HSA-9609646 | HCMV Infection | 1.646557e-01 | 0.783 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.086157e-01 | 0.681 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.717295e-01 | 0.765 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 1.453202e-01 | 0.838 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.252468e-01 | 0.647 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 9.926099e-02 | 1.003 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.615264e-01 | 0.582 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.428609e-01 | 0.615 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 2.098811e-01 | 0.678 |
| R-HSA-420092 | Glucagon-type ligand receptors | 1.511216e-01 | 0.821 |
| R-HSA-187687 | Signalling to ERKs | 1.998466e-01 | 0.699 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.238505e-01 | 0.650 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.549132e-01 | 0.594 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.136683e-01 | 0.670 |
| R-HSA-1643685 | Disease | 2.075652e-01 | 0.683 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 2.098811e-01 | 0.678 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.786991e-01 | 0.748 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.985946e-01 | 0.702 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.403146e-01 | 0.619 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 9.926099e-02 | 1.003 |
| R-HSA-450294 | MAP kinase activation | 1.551773e-01 | 0.809 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.579361e-01 | 0.802 |
| R-HSA-448424 | Interleukin-17 signaling | 1.985946e-01 | 0.702 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 1.786991e-01 | 0.748 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 1.321232e-01 | 0.879 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 2.695795e-01 | 0.569 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.054328e-01 | 0.977 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.073420e-01 | 0.683 |
| R-HSA-8983711 | OAS antiviral response | 2.695795e-01 | 0.569 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.153250e-01 | 0.938 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.645383e-01 | 0.578 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.195594e-01 | 0.658 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.195594e-01 | 0.658 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.073420e-01 | 0.683 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.993108e-01 | 0.700 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.361472e-01 | 0.627 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.286483e-01 | 0.641 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.369583e-01 | 0.863 |
| R-HSA-8979227 | Triglyceride metabolism | 1.459737e-01 | 0.836 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.706690e-01 | 0.568 |
| R-HSA-1500620 | Meiosis | 2.759457e-01 | 0.559 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.787352e-01 | 0.555 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.787352e-01 | 0.555 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.789965e-01 | 0.554 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.789965e-01 | 0.554 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.789965e-01 | 0.554 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 2.789965e-01 | 0.554 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.789965e-01 | 0.554 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.789965e-01 | 0.554 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.837877e-01 | 0.547 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.837877e-01 | 0.547 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.837877e-01 | 0.547 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.837877e-01 | 0.547 |
| R-HSA-421270 | Cell-cell junction organization | 2.847385e-01 | 0.546 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 2.862194e-01 | 0.543 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.862194e-01 | 0.543 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.862194e-01 | 0.543 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.865289e-01 | 0.543 |
| R-HSA-6809371 | Formation of the cornified envelope | 2.874078e-01 | 0.542 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.874078e-01 | 0.542 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.934348e-01 | 0.532 |
| R-HSA-418457 | cGMP effects | 2.977204e-01 | 0.526 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.977204e-01 | 0.526 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.977204e-01 | 0.526 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.006401e-01 | 0.522 |
| R-HSA-69481 | G2/M Checkpoints | 3.048621e-01 | 0.516 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.089285e-01 | 0.510 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 3.113829e-01 | 0.507 |
| R-HSA-418885 | DCC mediated attractive signaling | 3.113829e-01 | 0.507 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.113829e-01 | 0.507 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.113829e-01 | 0.507 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 3.113829e-01 | 0.507 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 3.113829e-01 | 0.507 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 3.113829e-01 | 0.507 |
| R-HSA-73942 | DNA Damage Reversal | 3.113829e-01 | 0.507 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.184329e-01 | 0.497 |
| R-HSA-2514856 | The phototransduction cascade | 3.221736e-01 | 0.492 |
| R-HSA-912446 | Meiotic recombination | 3.221736e-01 | 0.492 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.247804e-01 | 0.488 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 3.247804e-01 | 0.488 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.247804e-01 | 0.488 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 3.247804e-01 | 0.488 |
| R-HSA-9664420 | Killing mechanisms | 3.247804e-01 | 0.488 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 3.247804e-01 | 0.488 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 3.247804e-01 | 0.488 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 3.247804e-01 | 0.488 |
| R-HSA-9945266 | Differentiation of T cells | 3.247804e-01 | 0.488 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.256195e-01 | 0.487 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.293167e-01 | 0.482 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.293167e-01 | 0.482 |
| R-HSA-73894 | DNA Repair | 3.312359e-01 | 0.480 |
| R-HSA-9909396 | Circadian clock | 3.312385e-01 | 0.480 |
| R-HSA-74160 | Gene expression (Transcription) | 3.313610e-01 | 0.480 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.332851e-01 | 0.477 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.364391e-01 | 0.473 |
| R-HSA-1221632 | Meiotic synapsis | 3.364391e-01 | 0.473 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.364391e-01 | 0.473 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 3.379181e-01 | 0.471 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.379181e-01 | 0.471 |
| R-HSA-168255 | Influenza Infection | 3.486623e-01 | 0.458 |
| R-HSA-1296071 | Potassium Channels | 3.503855e-01 | 0.455 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.506142e-01 | 0.455 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.508010e-01 | 0.455 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 3.508010e-01 | 0.455 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.508010e-01 | 0.455 |
| R-HSA-2028269 | Signaling by Hippo | 3.508010e-01 | 0.455 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 3.508010e-01 | 0.455 |
| R-HSA-1280218 | Adaptive Immune System | 3.513709e-01 | 0.454 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.533116e-01 | 0.452 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.535515e-01 | 0.452 |
| R-HSA-5578775 | Ion homeostasis | 3.576634e-01 | 0.447 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.576634e-01 | 0.447 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.576634e-01 | 0.447 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.576634e-01 | 0.447 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.576634e-01 | 0.447 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.577292e-01 | 0.446 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.610094e-01 | 0.442 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.610094e-01 | 0.442 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.610094e-01 | 0.442 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.610094e-01 | 0.442 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.634340e-01 | 0.440 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 3.634340e-01 | 0.440 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.634340e-01 | 0.440 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.645485e-01 | 0.438 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.663121e-01 | 0.436 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.716768e-01 | 0.430 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.758219e-01 | 0.425 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 3.758219e-01 | 0.425 |
| R-HSA-159424 | Conjugation of carboxylic acids | 3.758219e-01 | 0.425 |
| R-HSA-156587 | Amino Acid conjugation | 3.758219e-01 | 0.425 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.758219e-01 | 0.425 |
| R-HSA-392517 | Rap1 signalling | 3.758219e-01 | 0.425 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 3.758219e-01 | 0.425 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.758219e-01 | 0.425 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 3.758219e-01 | 0.425 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.758219e-01 | 0.425 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.768945e-01 | 0.424 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.786379e-01 | 0.422 |
| R-HSA-191859 | snRNP Assembly | 3.786379e-01 | 0.422 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.786379e-01 | 0.422 |
| R-HSA-9033241 | Peroxisomal protein import | 3.786379e-01 | 0.422 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.786379e-01 | 0.422 |
| R-HSA-379724 | tRNA Aminoacylation | 3.855667e-01 | 0.414 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.855667e-01 | 0.414 |
| R-HSA-8848584 | Wax and plasmalogen biosynthesis | 3.879694e-01 | 0.411 |
| R-HSA-9823730 | Formation of definitive endoderm | 3.879694e-01 | 0.411 |
| R-HSA-1181150 | Signaling by NODAL | 3.879694e-01 | 0.411 |
| R-HSA-3322077 | Glycogen synthesis | 3.879694e-01 | 0.411 |
| R-HSA-112043 | PLC beta mediated events | 3.924618e-01 | 0.406 |
| R-HSA-445717 | Aquaporin-mediated transport | 3.924618e-01 | 0.406 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.949353e-01 | 0.403 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.979442e-01 | 0.400 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.979442e-01 | 0.400 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.993219e-01 | 0.399 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.993219e-01 | 0.399 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.998813e-01 | 0.398 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.998813e-01 | 0.398 |
| R-HSA-210991 | Basigin interactions | 3.998813e-01 | 0.398 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.040248e-01 | 0.394 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.061458e-01 | 0.391 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.083986e-01 | 0.389 |
| R-HSA-166520 | Signaling by NTRKs | 4.105570e-01 | 0.387 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 4.115621e-01 | 0.386 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.115621e-01 | 0.386 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 4.115621e-01 | 0.386 |
| R-HSA-977347 | Serine metabolism | 4.115621e-01 | 0.386 |
| R-HSA-175474 | Assembly Of The HIV Virion | 4.115621e-01 | 0.386 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 4.115621e-01 | 0.386 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.129322e-01 | 0.384 |
| R-HSA-211000 | Gene Silencing by RNA | 4.136057e-01 | 0.383 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.169145e-01 | 0.380 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.187983e-01 | 0.378 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.192926e-01 | 0.377 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.196800e-01 | 0.377 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.196800e-01 | 0.377 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 4.230162e-01 | 0.374 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.236494e-01 | 0.373 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.239757e-01 | 0.373 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.262753e-01 | 0.370 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.330559e-01 | 0.363 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 4.342481e-01 | 0.362 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 4.342481e-01 | 0.362 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 4.342481e-01 | 0.362 |
| R-HSA-8854691 | Interleukin-20 family signaling | 4.342481e-01 | 0.362 |
| R-HSA-167172 | Transcription of the HIV genome | 4.396819e-01 | 0.357 |
| R-HSA-5218859 | Regulated Necrosis | 4.396819e-01 | 0.357 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.409260e-01 | 0.356 |
| R-HSA-1989781 | PPARA activates gene expression | 4.409925e-01 | 0.356 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.445212e-01 | 0.352 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 4.452619e-01 | 0.351 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.452619e-01 | 0.351 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 4.452619e-01 | 0.351 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.496076e-01 | 0.347 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.496133e-01 | 0.347 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.528056e-01 | 0.344 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.528056e-01 | 0.344 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.528056e-01 | 0.344 |
| R-HSA-5688426 | Deubiquitination | 4.538534e-01 | 0.343 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.538996e-01 | 0.343 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.546865e-01 | 0.342 |
| R-HSA-3000157 | Laminin interactions | 4.560621e-01 | 0.341 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.560621e-01 | 0.341 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.560621e-01 | 0.341 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.560621e-01 | 0.341 |
| R-HSA-3214842 | HDMs demethylate histones | 4.560621e-01 | 0.341 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.560621e-01 | 0.341 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.593016e-01 | 0.338 |
| R-HSA-3000178 | ECM proteoglycans | 4.593016e-01 | 0.338 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.597403e-01 | 0.337 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.657527e-01 | 0.332 |
| R-HSA-3295583 | TRP channels | 4.666526e-01 | 0.331 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.666526e-01 | 0.331 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.666526e-01 | 0.331 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 4.666526e-01 | 0.331 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.666526e-01 | 0.331 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 4.666526e-01 | 0.331 |
| R-HSA-9845614 | Sphingolipid catabolism | 4.666526e-01 | 0.331 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.747794e-01 | 0.324 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.747794e-01 | 0.324 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.785174e-01 | 0.320 |
| R-HSA-397014 | Muscle contraction | 4.786237e-01 | 0.320 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.848297e-01 | 0.314 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.860161e-01 | 0.313 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.872210e-01 | 0.312 |
| R-HSA-77387 | Insulin receptor recycling | 4.872210e-01 | 0.312 |
| R-HSA-5620971 | Pyroptosis | 4.872210e-01 | 0.312 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.910946e-01 | 0.309 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.910946e-01 | 0.309 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.972067e-01 | 0.303 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.972067e-01 | 0.303 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.972067e-01 | 0.303 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 4.972067e-01 | 0.303 |
| R-HSA-180024 | DARPP-32 events | 4.972067e-01 | 0.303 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.978664e-01 | 0.303 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.034796e-01 | 0.298 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.034796e-01 | 0.298 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 5.042629e-01 | 0.297 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.046173e-01 | 0.297 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 5.069985e-01 | 0.295 |
| R-HSA-2424491 | DAP12 signaling | 5.069985e-01 | 0.295 |
| R-HSA-114452 | Activation of BH3-only proteins | 5.069985e-01 | 0.295 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 5.069985e-01 | 0.295 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.095988e-01 | 0.293 |
| R-HSA-6806834 | Signaling by MET | 5.156686e-01 | 0.288 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.156686e-01 | 0.288 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.166002e-01 | 0.287 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 5.166002e-01 | 0.287 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 5.166002e-01 | 0.287 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 5.166002e-01 | 0.287 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 5.166002e-01 | 0.287 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.216886e-01 | 0.283 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.260156e-01 | 0.279 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 5.260156e-01 | 0.279 |
| R-HSA-4791275 | Signaling by WNT in cancer | 5.260156e-01 | 0.279 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.328752e-01 | 0.273 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.335777e-01 | 0.273 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.352481e-01 | 0.271 |
| R-HSA-354192 | Integrin signaling | 5.352481e-01 | 0.271 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.352481e-01 | 0.271 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.352481e-01 | 0.271 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.352481e-01 | 0.271 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.352481e-01 | 0.271 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.438456e-01 | 0.265 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.443013e-01 | 0.264 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 5.443013e-01 | 0.264 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.443013e-01 | 0.264 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 5.443013e-01 | 0.264 |
| R-HSA-1474165 | Reproduction | 5.468297e-01 | 0.262 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.510297e-01 | 0.259 |
| R-HSA-9717189 | Sensory perception of taste | 5.514270e-01 | 0.259 |
| R-HSA-9843745 | Adipogenesis | 5.514270e-01 | 0.259 |
| R-HSA-5576891 | Cardiac conduction | 5.514270e-01 | 0.259 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.531787e-01 | 0.257 |
| R-HSA-5205647 | Mitophagy | 5.531787e-01 | 0.257 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.531787e-01 | 0.257 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.531787e-01 | 0.257 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.531787e-01 | 0.257 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.531787e-01 | 0.257 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.567443e-01 | 0.254 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.580301e-01 | 0.253 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.581459e-01 | 0.253 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.618837e-01 | 0.250 |
| R-HSA-169911 | Regulation of Apoptosis | 5.618837e-01 | 0.250 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.618837e-01 | 0.250 |
| R-HSA-70268 | Pyruvate metabolism | 5.624071e-01 | 0.250 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.624071e-01 | 0.250 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.628879e-01 | 0.250 |
| R-HSA-111933 | Calmodulin induced events | 5.704197e-01 | 0.244 |
| R-HSA-111997 | CaM pathway | 5.704197e-01 | 0.244 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.704197e-01 | 0.244 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.704197e-01 | 0.244 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 5.704197e-01 | 0.244 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.735772e-01 | 0.241 |
| R-HSA-9679506 | SARS-CoV Infections | 5.785275e-01 | 0.238 |
| R-HSA-4641257 | Degradation of AXIN | 5.787898e-01 | 0.237 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.787898e-01 | 0.237 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 5.787898e-01 | 0.237 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.790841e-01 | 0.237 |
| R-HSA-73884 | Base Excision Repair | 5.790841e-01 | 0.237 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.848257e-01 | 0.233 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.869974e-01 | 0.231 |
| R-HSA-9931953 | Biofilm formation | 5.869974e-01 | 0.231 |
| R-HSA-1566948 | Elastic fibre formation | 5.869974e-01 | 0.231 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.869974e-01 | 0.231 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.915347e-01 | 0.228 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.949212e-01 | 0.226 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.950456e-01 | 0.225 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.950456e-01 | 0.225 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.005897e-01 | 0.221 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 6.029374e-01 | 0.220 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 6.029374e-01 | 0.220 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 6.029374e-01 | 0.220 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 6.029374e-01 | 0.220 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 6.029374e-01 | 0.220 |
| R-HSA-5260271 | Diseases of Immune System | 6.029374e-01 | 0.220 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.029374e-01 | 0.220 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 6.029374e-01 | 0.220 |
| R-HSA-451927 | Interleukin-2 family signaling | 6.029374e-01 | 0.220 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.086030e-01 | 0.216 |
| R-HSA-4839726 | Chromatin organization | 6.087668e-01 | 0.216 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 6.106758e-01 | 0.214 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 6.106758e-01 | 0.214 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 6.106758e-01 | 0.214 |
| R-HSA-9607240 | FLT3 Signaling | 6.106758e-01 | 0.214 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 6.106758e-01 | 0.214 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.127954e-01 | 0.213 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.161701e-01 | 0.210 |
| R-HSA-449147 | Signaling by Interleukins | 6.169189e-01 | 0.210 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 6.182640e-01 | 0.209 |
| R-HSA-167161 | HIV Transcription Initiation | 6.182640e-01 | 0.209 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 6.182640e-01 | 0.209 |
| R-HSA-6811438 | Intra-Golgi traffic | 6.182640e-01 | 0.209 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.182640e-01 | 0.209 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 6.182640e-01 | 0.209 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 6.182640e-01 | 0.209 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 6.182640e-01 | 0.209 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.212592e-01 | 0.207 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.212592e-01 | 0.207 |
| R-HSA-111996 | Ca-dependent events | 6.257046e-01 | 0.204 |
| R-HSA-73928 | Depyrimidination | 6.257046e-01 | 0.204 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 6.257046e-01 | 0.204 |
| R-HSA-168256 | Immune System | 6.287649e-01 | 0.202 |
| R-HSA-190236 | Signaling by FGFR | 6.312813e-01 | 0.200 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.330008e-01 | 0.199 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 6.330008e-01 | 0.199 |
| R-HSA-69242 | S Phase | 6.333035e-01 | 0.198 |
| R-HSA-9907900 | Proteasome assembly | 6.401551e-01 | 0.194 |
| R-HSA-373752 | Netrin-1 signaling | 6.401551e-01 | 0.194 |
| R-HSA-2172127 | DAP12 interactions | 6.401551e-01 | 0.194 |
| R-HSA-69236 | G1 Phase | 6.401551e-01 | 0.194 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.401551e-01 | 0.194 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 6.401551e-01 | 0.194 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.401551e-01 | 0.194 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.471704e-01 | 0.189 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.471704e-01 | 0.189 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.471704e-01 | 0.189 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 6.471704e-01 | 0.189 |
| R-HSA-9824272 | Somitogenesis | 6.471704e-01 | 0.189 |
| R-HSA-6805567 | Keratinization | 6.483589e-01 | 0.188 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.491606e-01 | 0.188 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.507043e-01 | 0.187 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.507043e-01 | 0.187 |
| R-HSA-9609507 | Protein localization | 6.530481e-01 | 0.185 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.540493e-01 | 0.184 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.540493e-01 | 0.184 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.540493e-01 | 0.184 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 6.540493e-01 | 0.184 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.569048e-01 | 0.182 |
| R-HSA-73887 | Death Receptor Signaling | 6.569048e-01 | 0.182 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.601075e-01 | 0.180 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.607946e-01 | 0.180 |
| R-HSA-9031628 | NGF-stimulated transcription | 6.674087e-01 | 0.176 |
| R-HSA-425410 | Metal ion SLC transporters | 6.674087e-01 | 0.176 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.674087e-01 | 0.176 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.693072e-01 | 0.174 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.738943e-01 | 0.171 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 6.802538e-01 | 0.167 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.802538e-01 | 0.167 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.807972e-01 | 0.167 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.827288e-01 | 0.166 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.864897e-01 | 0.163 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 6.864897e-01 | 0.163 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 6.864897e-01 | 0.163 |
| R-HSA-1474244 | Extracellular matrix organization | 6.874909e-01 | 0.163 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.926043e-01 | 0.160 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.926043e-01 | 0.160 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.986000e-01 | 0.156 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.986000e-01 | 0.156 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.999288e-01 | 0.155 |
| R-HSA-5619102 | SLC transporter disorders | 7.042406e-01 | 0.152 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 7.044792e-01 | 0.152 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 7.044792e-01 | 0.152 |
| R-HSA-156588 | Glucuronidation | 7.044792e-01 | 0.152 |
| R-HSA-3214815 | HDACs deacetylate histones | 7.102440e-01 | 0.149 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 7.102440e-01 | 0.149 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.158967e-01 | 0.145 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 7.158967e-01 | 0.145 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.163501e-01 | 0.145 |
| R-HSA-72306 | tRNA processing | 7.177651e-01 | 0.144 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.203359e-01 | 0.142 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.210706e-01 | 0.142 |
| R-HSA-5621480 | Dectin-2 family | 7.214395e-01 | 0.142 |
| R-HSA-168249 | Innate Immune System | 7.221515e-01 | 0.141 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.243460e-01 | 0.140 |
| R-HSA-6782135 | Dual incision in TC-NER | 7.268745e-01 | 0.139 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.308069e-01 | 0.136 |
| R-HSA-186712 | Regulation of beta-cell development | 7.322038e-01 | 0.135 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.374294e-01 | 0.132 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.374294e-01 | 0.132 |
| R-HSA-351202 | Metabolism of polyamines | 7.374294e-01 | 0.132 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 7.374294e-01 | 0.132 |
| R-HSA-211976 | Endogenous sterols | 7.425533e-01 | 0.129 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.425533e-01 | 0.129 |
| R-HSA-3371556 | Cellular response to heat stress | 7.432718e-01 | 0.129 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.432718e-01 | 0.129 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.432718e-01 | 0.129 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.475776e-01 | 0.126 |
| R-HSA-9707616 | Heme signaling | 7.475776e-01 | 0.126 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.475776e-01 | 0.126 |
| R-HSA-1268020 | Mitochondrial protein import | 7.475776e-01 | 0.126 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.475776e-01 | 0.126 |
| R-HSA-186797 | Signaling by PDGF | 7.475776e-01 | 0.126 |
| R-HSA-157118 | Signaling by NOTCH | 7.513244e-01 | 0.124 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.525041e-01 | 0.123 |
| R-HSA-8848021 | Signaling by PTK6 | 7.525041e-01 | 0.123 |
| R-HSA-373755 | Semaphorin interactions | 7.525041e-01 | 0.123 |
| R-HSA-211981 | Xenobiotics | 7.573348e-01 | 0.121 |
| R-HSA-500792 | GPCR ligand binding | 7.600639e-01 | 0.119 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.611400e-01 | 0.119 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.611400e-01 | 0.119 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.611400e-01 | 0.119 |
| R-HSA-69206 | G1/S Transition | 7.611400e-01 | 0.119 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 7.667160e-01 | 0.115 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 7.667160e-01 | 0.115 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.693784e-01 | 0.114 |
| R-HSA-196807 | Nicotinate metabolism | 7.712701e-01 | 0.113 |
| R-HSA-983712 | Ion channel transport | 7.755286e-01 | 0.110 |
| R-HSA-913709 | O-linked glycosylation of mucins | 7.757356e-01 | 0.110 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 7.757356e-01 | 0.110 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 7.757356e-01 | 0.110 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 7.801142e-01 | 0.108 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.844076e-01 | 0.105 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 7.844076e-01 | 0.105 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.874922e-01 | 0.104 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 7.886174e-01 | 0.103 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.886174e-01 | 0.103 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.886174e-01 | 0.103 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 7.927452e-01 | 0.101 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.927452e-01 | 0.101 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.967927e-01 | 0.099 |
| R-HSA-9749641 | Aspirin ADME | 7.967927e-01 | 0.099 |
| R-HSA-9013694 | Signaling by NOTCH4 | 8.007614e-01 | 0.096 |
| R-HSA-1226099 | Signaling by FGFR in disease | 8.007614e-01 | 0.096 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.040110e-01 | 0.095 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.043142e-01 | 0.095 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 8.046528e-01 | 0.094 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.084214e-01 | 0.092 |
| R-HSA-5689603 | UCH proteinases | 8.084685e-01 | 0.092 |
| R-HSA-1980143 | Signaling by NOTCH1 | 8.084685e-01 | 0.092 |
| R-HSA-6807070 | PTEN Regulation | 8.112571e-01 | 0.091 |
| R-HSA-9664407 | Parasite infection | 8.140555e-01 | 0.089 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.140555e-01 | 0.089 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.140555e-01 | 0.089 |
| R-HSA-216083 | Integrin cell surface interactions | 8.158783e-01 | 0.088 |
| R-HSA-5619084 | ABC transporter disorders | 8.158783e-01 | 0.088 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.168167e-01 | 0.088 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.251346e-01 | 0.083 |
| R-HSA-977225 | Amyloid fiber formation | 8.264607e-01 | 0.083 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.298516e-01 | 0.081 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.326278e-01 | 0.080 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 8.331765e-01 | 0.079 |
| R-HSA-2187338 | Visual phototransduction | 8.351404e-01 | 0.078 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.364366e-01 | 0.078 |
| R-HSA-9758941 | Gastrulation | 8.400638e-01 | 0.076 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.427676e-01 | 0.074 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.472000e-01 | 0.072 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.509625e-01 | 0.070 |
| R-HSA-156902 | Peptide chain elongation | 8.518089e-01 | 0.070 |
| R-HSA-202424 | Downstream TCR signaling | 8.575466e-01 | 0.067 |
| R-HSA-9610379 | HCMV Late Events | 8.584542e-01 | 0.066 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.603318e-01 | 0.065 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 8.603318e-01 | 0.065 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.630628e-01 | 0.064 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.656804e-01 | 0.063 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.657405e-01 | 0.063 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.657405e-01 | 0.063 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.683660e-01 | 0.061 |
| R-HSA-1474290 | Collagen formation | 8.709404e-01 | 0.060 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.729418e-01 | 0.059 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.734645e-01 | 0.059 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.734645e-01 | 0.059 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.759395e-01 | 0.058 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.759395e-01 | 0.058 |
| R-HSA-157579 | Telomere Maintenance | 8.807455e-01 | 0.055 |
| R-HSA-3214847 | HATs acetylate histones | 8.853660e-01 | 0.053 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.853660e-01 | 0.053 |
| R-HSA-382556 | ABC-family proteins mediated transport | 8.876088e-01 | 0.052 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.898079e-01 | 0.051 |
| R-HSA-1483255 | PI Metabolism | 8.919641e-01 | 0.050 |
| R-HSA-192823 | Viral mRNA Translation | 8.940783e-01 | 0.049 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.961512e-01 | 0.048 |
| R-HSA-9833110 | RSV-host interactions | 8.981837e-01 | 0.047 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.040462e-01 | 0.044 |
| R-HSA-69239 | Synthesis of DNA | 9.040462e-01 | 0.044 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 9.059246e-01 | 0.043 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 9.059246e-01 | 0.043 |
| R-HSA-2672351 | Stimuli-sensing channels | 9.059246e-01 | 0.043 |
| R-HSA-8957322 | Metabolism of steroids | 9.066794e-01 | 0.043 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 9.077664e-01 | 0.042 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.082121e-01 | 0.042 |
| R-HSA-202403 | TCR signaling | 9.095722e-01 | 0.041 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 9.095722e-01 | 0.041 |
| R-HSA-6803157 | Antimicrobial peptides | 9.113427e-01 | 0.040 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 9.130787e-01 | 0.039 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 9.130787e-01 | 0.039 |
| R-HSA-597592 | Post-translational protein modification | 9.191796e-01 | 0.037 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.212635e-01 | 0.036 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.212635e-01 | 0.036 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 9.228058e-01 | 0.035 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 9.228058e-01 | 0.035 |
| R-HSA-9007101 | Rab regulation of trafficking | 9.243180e-01 | 0.034 |
| R-HSA-73886 | Chromosome Maintenance | 9.300772e-01 | 0.031 |
| R-HSA-428157 | Sphingolipid metabolism | 9.303894e-01 | 0.031 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.326031e-01 | 0.030 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.379071e-01 | 0.028 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 9.448626e-01 | 0.025 |
| R-HSA-8951664 | Neddylation | 9.505599e-01 | 0.022 |
| R-HSA-5173105 | O-linked glycosylation | 9.520017e-01 | 0.021 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.590390e-01 | 0.018 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.632957e-01 | 0.016 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.650473e-01 | 0.015 |
| R-HSA-69306 | DNA Replication | 9.657337e-01 | 0.015 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.683475e-01 | 0.014 |
| R-HSA-9711097 | Cellular response to starvation | 9.689693e-01 | 0.014 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.733807e-01 | 0.012 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.740451e-01 | 0.011 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.760266e-01 | 0.011 |
| R-HSA-72766 | Translation | 9.774419e-01 | 0.010 |
| R-HSA-611105 | Respiratory electron transport | 9.795486e-01 | 0.009 |
| R-HSA-3781865 | Diseases of glycosylation | 9.818472e-01 | 0.008 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.825546e-01 | 0.008 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.832345e-01 | 0.007 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.875591e-01 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 9.890556e-01 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 9.896929e-01 | 0.004 |
| R-HSA-9748784 | Drug ADME | 9.909527e-01 | 0.004 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.928768e-01 | 0.003 |
| R-HSA-72312 | rRNA processing | 9.931552e-01 | 0.003 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.938047e-01 | 0.003 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.963128e-01 | 0.002 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.972678e-01 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.976843e-01 | 0.001 |
| R-HSA-1483257 | Phospholipid metabolism | 9.980554e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.980654e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.985993e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.987055e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.992623e-01 | 0.000 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.995128e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.998658e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999634e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999957e-01 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.815 | 0.135 | 2 | 0.925 |
DSTYK |
0.803 | 0.076 | 2 | 0.941 |
NEK6 |
0.803 | 0.143 | -2 | 0.293 |
GCN2 |
0.802 | -0.007 | 2 | 0.901 |
ULK2 |
0.801 | 0.046 | 2 | 0.890 |
NEK7 |
0.800 | 0.105 | -3 | 0.848 |
PRPK |
0.798 | 0.131 | -1 | 0.861 |
RIPK3 |
0.797 | 0.111 | 3 | 0.781 |
SKMLCK |
0.797 | 0.127 | -2 | 0.258 |
WNK1 |
0.797 | 0.177 | -2 | 0.324 |
MARK4 |
0.794 | 0.107 | 4 | 0.854 |
TGFBR2 |
0.794 | -0.035 | -2 | 0.193 |
MOS |
0.793 | 0.008 | 1 | 0.917 |
PIM3 |
0.792 | -0.009 | -3 | 0.741 |
NEK9 |
0.792 | 0.106 | 2 | 0.919 |
CDC7 |
0.792 | -0.024 | 1 | 0.895 |
NDR2 |
0.790 | 0.013 | -3 | 0.746 |
CHAK2 |
0.790 | 0.054 | -1 | 0.836 |
CAMK2G |
0.789 | 0.010 | 2 | 0.886 |
IKKB |
0.789 | -0.119 | -2 | 0.144 |
MLK1 |
0.789 | 0.018 | 2 | 0.896 |
BMPR2 |
0.789 | 0.004 | -2 | 0.235 |
PKCD |
0.789 | 0.063 | 2 | 0.880 |
MTOR |
0.789 | 0.023 | 1 | 0.766 |
PDHK4 |
0.789 | -0.026 | 1 | 0.851 |
PKN3 |
0.789 | 0.036 | -3 | 0.758 |
ULK1 |
0.788 | -0.028 | -3 | 0.814 |
TBK1 |
0.788 | -0.012 | 1 | 0.720 |
NLK |
0.788 | -0.014 | 1 | 0.805 |
RAF1 |
0.787 | -0.086 | 1 | 0.851 |
NIM1 |
0.787 | 0.057 | 3 | 0.732 |
PDHK1 |
0.786 | 0.015 | 1 | 0.830 |
CLK3 |
0.786 | 0.040 | 1 | 0.816 |
AURC |
0.786 | -0.029 | -2 | 0.143 |
NDR1 |
0.786 | -0.013 | -3 | 0.747 |
CDKL1 |
0.786 | 0.002 | -3 | 0.729 |
MASTL |
0.786 | 0.012 | -2 | 0.236 |
MST4 |
0.785 | 0.039 | 2 | 0.886 |
BCKDK |
0.784 | 0.048 | -1 | 0.817 |
CAMK1B |
0.784 | -0.054 | -3 | 0.784 |
ANKRD3 |
0.784 | 0.108 | 1 | 0.883 |
IRE1 |
0.784 | 0.063 | 1 | 0.853 |
IKKE |
0.784 | -0.057 | 1 | 0.709 |
WNK3 |
0.784 | 0.032 | 1 | 0.836 |
CAMK2D |
0.784 | 0.046 | -3 | 0.787 |
NEK2 |
0.784 | 0.110 | 2 | 0.898 |
ATR |
0.784 | -0.016 | 1 | 0.866 |
PKN2 |
0.784 | 0.005 | -3 | 0.756 |
MLK2 |
0.784 | 0.021 | 2 | 0.903 |
CAMLCK |
0.783 | -0.016 | -2 | 0.201 |
CDKL5 |
0.783 | 0.007 | -3 | 0.724 |
PRKD1 |
0.783 | -0.018 | -3 | 0.761 |
P90RSK |
0.783 | 0.014 | -3 | 0.700 |
ERK5 |
0.783 | -0.026 | 1 | 0.770 |
MLK3 |
0.782 | 0.048 | 2 | 0.839 |
MNK2 |
0.782 | 0.014 | -2 | 0.218 |
HUNK |
0.782 | -0.052 | 2 | 0.903 |
RIPK1 |
0.782 | 0.019 | 1 | 0.867 |
NIK |
0.782 | -0.012 | -3 | 0.812 |
PKCZ |
0.782 | 0.078 | 2 | 0.875 |
SRPK1 |
0.782 | 0.030 | -3 | 0.670 |
AURB |
0.781 | -0.033 | -2 | 0.140 |
GRK5 |
0.781 | -0.077 | -3 | 0.782 |
PKCA |
0.781 | 0.074 | 2 | 0.826 |
DAPK2 |
0.781 | -0.006 | -3 | 0.801 |
RSK2 |
0.781 | -0.014 | -3 | 0.684 |
IRE2 |
0.780 | 0.062 | 2 | 0.850 |
PKACG |
0.780 | -0.055 | -2 | 0.167 |
NUAK2 |
0.780 | -0.025 | -3 | 0.745 |
PKCB |
0.780 | 0.063 | 2 | 0.828 |
GRK1 |
0.780 | -0.039 | -2 | 0.154 |
RSK3 |
0.779 | -0.016 | -3 | 0.687 |
HIPK4 |
0.779 | -0.004 | 1 | 0.801 |
IKKA |
0.779 | -0.073 | -2 | 0.153 |
PKCG |
0.779 | 0.038 | 2 | 0.838 |
AMPKA1 |
0.778 | -0.001 | -3 | 0.769 |
QSK |
0.778 | 0.042 | 4 | 0.831 |
LATS2 |
0.778 | -0.002 | -5 | 0.792 |
PIM1 |
0.778 | -0.009 | -3 | 0.682 |
TSSK2 |
0.778 | 0.004 | -5 | 0.851 |
PLK1 |
0.778 | -0.030 | -2 | 0.196 |
MAPKAPK3 |
0.777 | -0.027 | -3 | 0.702 |
ATM |
0.777 | 0.027 | 1 | 0.819 |
TGFBR1 |
0.777 | -0.011 | -2 | 0.197 |
TSSK1 |
0.777 | 0.029 | -3 | 0.787 |
PRP4 |
0.777 | 0.135 | -3 | 0.858 |
BMPR1B |
0.776 | 0.014 | 1 | 0.846 |
QIK |
0.776 | -0.009 | -3 | 0.771 |
PRKD2 |
0.776 | -0.041 | -3 | 0.689 |
CHAK1 |
0.776 | 0.032 | 2 | 0.872 |
SMG1 |
0.776 | 0.060 | 1 | 0.818 |
PKG2 |
0.776 | -0.043 | -2 | 0.138 |
FAM20C |
0.776 | 0.042 | 2 | 0.636 |
PKR |
0.776 | 0.063 | 1 | 0.887 |
MLK4 |
0.776 | 0.027 | 2 | 0.827 |
KIS |
0.775 | -0.026 | 1 | 0.649 |
PAK1 |
0.775 | -0.048 | -2 | 0.165 |
ICK |
0.775 | -0.033 | -3 | 0.764 |
MARK3 |
0.775 | 0.050 | 4 | 0.803 |
AURA |
0.775 | -0.047 | -2 | 0.134 |
ALK4 |
0.775 | -0.023 | -2 | 0.204 |
PAK3 |
0.774 | -0.066 | -2 | 0.155 |
WNK4 |
0.774 | 0.223 | -2 | 0.360 |
GRK4 |
0.774 | -0.086 | -2 | 0.204 |
PKCH |
0.774 | 0.026 | 2 | 0.832 |
MELK |
0.774 | -0.021 | -3 | 0.728 |
NEK5 |
0.773 | 0.205 | 1 | 0.865 |
VRK2 |
0.773 | 0.208 | 1 | 0.885 |
MNK1 |
0.773 | -0.016 | -2 | 0.193 |
TTBK2 |
0.773 | -0.077 | 2 | 0.822 |
CAMK2B |
0.773 | 0.037 | 2 | 0.840 |
MARK2 |
0.773 | 0.052 | 4 | 0.765 |
P70S6KB |
0.772 | -0.047 | -3 | 0.711 |
PKACB |
0.772 | -0.037 | -2 | 0.149 |
CDK13 |
0.772 | 0.038 | 1 | 0.600 |
IRAK4 |
0.772 | 0.090 | 1 | 0.851 |
MSK2 |
0.771 | -0.045 | -3 | 0.669 |
AMPKA2 |
0.771 | -0.025 | -3 | 0.730 |
GRK6 |
0.771 | -0.077 | 1 | 0.866 |
ACVR2B |
0.771 | -0.028 | -2 | 0.169 |
ALK2 |
0.771 | -0.011 | -2 | 0.195 |
SRPK2 |
0.770 | 0.000 | -3 | 0.593 |
PLK4 |
0.770 | 0.041 | 2 | 0.756 |
CDK8 |
0.770 | -0.032 | 1 | 0.615 |
PAK6 |
0.770 | -0.040 | -2 | 0.125 |
PHKG1 |
0.770 | 0.002 | -3 | 0.744 |
MAPKAPK2 |
0.770 | -0.015 | -3 | 0.637 |
ACVR2A |
0.770 | -0.042 | -2 | 0.176 |
MEKK1 |
0.769 | 0.092 | 1 | 0.822 |
CAMK4 |
0.769 | -0.092 | -3 | 0.732 |
CDK5 |
0.769 | 0.026 | 1 | 0.659 |
YSK4 |
0.769 | -0.024 | 1 | 0.768 |
NUAK1 |
0.769 | -0.036 | -3 | 0.702 |
MYLK4 |
0.769 | -0.049 | -2 | 0.160 |
SGK3 |
0.768 | 0.004 | -3 | 0.682 |
TLK2 |
0.768 | 0.042 | 1 | 0.830 |
SIK |
0.768 | -0.020 | -3 | 0.671 |
PERK |
0.768 | -0.049 | -2 | 0.200 |
HRI |
0.767 | -0.038 | -2 | 0.212 |
PKCT |
0.767 | 0.036 | 2 | 0.837 |
MSK1 |
0.767 | -0.034 | -3 | 0.666 |
PAK2 |
0.767 | -0.074 | -2 | 0.157 |
BRSK2 |
0.767 | -0.002 | -3 | 0.750 |
DRAK1 |
0.766 | 0.016 | 1 | 0.820 |
SNRK |
0.766 | -0.073 | 2 | 0.794 |
DLK |
0.766 | -0.173 | 1 | 0.842 |
MEK1 |
0.766 | -0.076 | 2 | 0.918 |
SRPK3 |
0.766 | -0.014 | -3 | 0.643 |
CDK19 |
0.765 | -0.031 | 1 | 0.572 |
DYRK2 |
0.765 | -0.010 | 1 | 0.678 |
CLK4 |
0.765 | -0.022 | -3 | 0.676 |
MARK1 |
0.765 | -0.009 | 4 | 0.820 |
DNAPK |
0.764 | 0.046 | 1 | 0.718 |
CDK12 |
0.764 | 0.032 | 1 | 0.567 |
RSK4 |
0.764 | -0.025 | -3 | 0.645 |
CDK18 |
0.764 | 0.028 | 1 | 0.559 |
PRKD3 |
0.764 | -0.060 | -3 | 0.664 |
PLK3 |
0.764 | -0.056 | 2 | 0.846 |
BRSK1 |
0.764 | -0.025 | -3 | 0.712 |
ZAK |
0.764 | 0.047 | 1 | 0.784 |
CLK1 |
0.764 | -0.004 | -3 | 0.657 |
PRKX |
0.763 | -0.040 | -3 | 0.569 |
LATS1 |
0.763 | -0.024 | -3 | 0.759 |
BMPR1A |
0.763 | -0.005 | 1 | 0.832 |
MEKK2 |
0.763 | 0.052 | 2 | 0.900 |
PKACA |
0.763 | -0.049 | -2 | 0.127 |
CAMK1G |
0.762 | -0.023 | -3 | 0.681 |
PKCI |
0.762 | 0.008 | 2 | 0.842 |
CAMK2A |
0.762 | -0.026 | 2 | 0.856 |
DCAMKL1 |
0.762 | 0.026 | -3 | 0.690 |
CDK7 |
0.762 | -0.027 | 1 | 0.633 |
AKT2 |
0.761 | -0.033 | -3 | 0.599 |
GRK7 |
0.761 | -0.033 | 1 | 0.787 |
GRK2 |
0.761 | -0.073 | -2 | 0.150 |
CLK2 |
0.761 | 0.036 | -3 | 0.652 |
MST3 |
0.760 | 0.063 | 2 | 0.895 |
PINK1 |
0.760 | -0.098 | 1 | 0.857 |
P38A |
0.760 | -0.014 | 1 | 0.658 |
CDK1 |
0.759 | -0.000 | 1 | 0.586 |
BRAF |
0.759 | -0.058 | -4 | 0.790 |
CDK2 |
0.759 | -0.019 | 1 | 0.677 |
MAPKAPK5 |
0.759 | -0.062 | -3 | 0.671 |
CDK9 |
0.759 | -0.015 | 1 | 0.606 |
MPSK1 |
0.759 | 0.020 | 1 | 0.849 |
PIM2 |
0.759 | -0.039 | -3 | 0.662 |
SMMLCK |
0.758 | -0.033 | -3 | 0.746 |
MEKK3 |
0.758 | -0.059 | 1 | 0.809 |
MEK5 |
0.758 | -0.067 | 2 | 0.909 |
PAK4 |
0.757 | -0.049 | -2 | 0.119 |
CAMKK1 |
0.756 | -0.091 | -2 | 0.159 |
AKT1 |
0.756 | -0.033 | -3 | 0.616 |
SSTK |
0.756 | -0.033 | 4 | 0.805 |
PHKG2 |
0.756 | -0.025 | -3 | 0.705 |
HIPK1 |
0.756 | -0.014 | 1 | 0.696 |
VRK1 |
0.756 | 0.277 | 2 | 0.918 |
PAK5 |
0.755 | -0.065 | -2 | 0.110 |
IRAK1 |
0.755 | -0.067 | -1 | 0.776 |
NEK4 |
0.755 | 0.064 | 1 | 0.804 |
CHK1 |
0.755 | -0.085 | -3 | 0.738 |
PKCE |
0.755 | 0.008 | 2 | 0.823 |
CDK3 |
0.755 | 0.022 | 1 | 0.521 |
NEK8 |
0.754 | 0.001 | 2 | 0.905 |
ERK1 |
0.754 | -0.028 | 1 | 0.562 |
TLK1 |
0.754 | -0.097 | -2 | 0.211 |
TAO3 |
0.753 | 0.032 | 1 | 0.796 |
DCAMKL2 |
0.753 | -0.014 | -3 | 0.718 |
DYRK1A |
0.753 | -0.027 | 1 | 0.705 |
JNK3 |
0.753 | -0.030 | 1 | 0.602 |
CDK17 |
0.752 | -0.006 | 1 | 0.499 |
DAPK3 |
0.752 | -0.010 | -3 | 0.706 |
LKB1 |
0.752 | -0.000 | -3 | 0.867 |
DYRK3 |
0.752 | -0.020 | 1 | 0.710 |
P38G |
0.752 | -0.002 | 1 | 0.487 |
NEK1 |
0.752 | 0.112 | 1 | 0.833 |
P38B |
0.752 | -0.024 | 1 | 0.569 |
HIPK2 |
0.752 | -0.019 | 1 | 0.586 |
TAO2 |
0.752 | 0.020 | 2 | 0.924 |
HIPK3 |
0.751 | -0.036 | 1 | 0.685 |
CDK14 |
0.751 | 0.003 | 1 | 0.606 |
JNK2 |
0.750 | -0.029 | 1 | 0.560 |
NEK11 |
0.750 | 0.003 | 1 | 0.796 |
CK1E |
0.750 | -0.053 | -3 | 0.446 |
GRK3 |
0.749 | -0.073 | -2 | 0.143 |
EEF2K |
0.749 | 0.028 | 3 | 0.763 |
PDK1 |
0.749 | 0.015 | 1 | 0.826 |
TNIK |
0.749 | 0.070 | 3 | 0.798 |
MINK |
0.748 | 0.047 | 1 | 0.786 |
DYRK1B |
0.748 | -0.024 | 1 | 0.620 |
CAMK1D |
0.748 | -0.041 | -3 | 0.616 |
NEK3 |
0.748 | 0.103 | 1 | 0.765 |
PKN1 |
0.748 | -0.017 | -3 | 0.651 |
CDK16 |
0.747 | 0.015 | 1 | 0.520 |
TTBK1 |
0.747 | -0.091 | 2 | 0.739 |
STK33 |
0.747 | -0.025 | 2 | 0.731 |
ERK2 |
0.747 | -0.060 | 1 | 0.613 |
HGK |
0.747 | 0.026 | 3 | 0.798 |
P70S6K |
0.747 | -0.067 | -3 | 0.633 |
CAMKK2 |
0.747 | -0.113 | -2 | 0.154 |
GAK |
0.747 | 0.029 | 1 | 0.890 |
DYRK4 |
0.746 | -0.017 | 1 | 0.586 |
P38D |
0.745 | -0.009 | 1 | 0.515 |
LRRK2 |
0.745 | 0.013 | 2 | 0.928 |
AKT3 |
0.745 | -0.035 | -3 | 0.540 |
MST2 |
0.745 | -0.027 | 1 | 0.802 |
MEKK6 |
0.744 | 0.016 | 1 | 0.789 |
GSK3A |
0.744 | 0.015 | 4 | 0.454 |
GCK |
0.744 | 0.014 | 1 | 0.795 |
ERK7 |
0.743 | 0.021 | 2 | 0.621 |
GSK3B |
0.743 | -0.012 | 4 | 0.442 |
PKG1 |
0.743 | -0.067 | -2 | 0.108 |
MAP3K15 |
0.743 | 0.014 | 1 | 0.766 |
DAPK1 |
0.742 | -0.040 | -3 | 0.692 |
MRCKB |
0.741 | -0.048 | -3 | 0.652 |
ROCK2 |
0.741 | -0.017 | -3 | 0.700 |
RIPK2 |
0.741 | -0.072 | 1 | 0.748 |
LOK |
0.741 | -0.054 | -2 | 0.170 |
TTK |
0.741 | 0.061 | -2 | 0.224 |
CK2A2 |
0.741 | -0.015 | 1 | 0.762 |
MAK |
0.740 | -0.014 | -2 | 0.170 |
SGK1 |
0.740 | -0.025 | -3 | 0.522 |
HPK1 |
0.740 | -0.007 | 1 | 0.771 |
KHS1 |
0.739 | 0.055 | 1 | 0.764 |
MEK2 |
0.739 | -0.061 | 2 | 0.899 |
TAK1 |
0.739 | -0.079 | 1 | 0.845 |
YSK1 |
0.739 | 0.038 | 2 | 0.885 |
CDK10 |
0.739 | -0.027 | 1 | 0.596 |
CK1D |
0.738 | -0.062 | -3 | 0.399 |
CDK6 |
0.738 | -0.017 | 1 | 0.585 |
KHS2 |
0.738 | 0.055 | 1 | 0.778 |
PASK |
0.738 | -0.053 | -3 | 0.762 |
MYO3B |
0.737 | 0.099 | 2 | 0.893 |
CAMK1A |
0.737 | -0.047 | -3 | 0.564 |
CK1G1 |
0.737 | -0.072 | -3 | 0.440 |
PBK |
0.736 | 0.023 | 1 | 0.816 |
CHK2 |
0.735 | -0.047 | -3 | 0.548 |
SLK |
0.734 | -0.089 | -2 | 0.152 |
MRCKA |
0.734 | -0.070 | -3 | 0.670 |
MST1 |
0.734 | -0.073 | 1 | 0.784 |
PLK2 |
0.733 | -0.056 | -3 | 0.739 |
CK2A1 |
0.733 | -0.014 | 1 | 0.737 |
CK1A2 |
0.733 | -0.070 | -3 | 0.394 |
OSR1 |
0.731 | 0.022 | 2 | 0.878 |
MOK |
0.731 | -0.021 | 1 | 0.731 |
CDK4 |
0.731 | -0.038 | 1 | 0.555 |
DMPK1 |
0.731 | -0.032 | -3 | 0.658 |
ROCK1 |
0.730 | -0.036 | -3 | 0.669 |
JNK1 |
0.727 | -0.051 | 1 | 0.551 |
BUB1 |
0.727 | -0.047 | -5 | 0.768 |
TAO1 |
0.727 | 0.038 | 1 | 0.719 |
PDHK3_TYR |
0.725 | 0.090 | 4 | 0.891 |
MYO3A |
0.725 | -0.013 | 1 | 0.797 |
HASPIN |
0.724 | 0.006 | -1 | 0.698 |
BIKE |
0.723 | 0.025 | 1 | 0.781 |
PKMYT1_TYR |
0.722 | 0.130 | 3 | 0.773 |
ASK1 |
0.721 | -0.022 | 1 | 0.751 |
BLK |
0.718 | 0.183 | -1 | 0.867 |
TESK1_TYR |
0.718 | 0.001 | 3 | 0.780 |
SBK |
0.717 | -0.068 | -3 | 0.483 |
MAP2K7_TYR |
0.717 | 0.032 | 2 | 0.934 |
TNK2 |
0.717 | 0.142 | 3 | 0.781 |
PDHK4_TYR |
0.717 | 0.044 | 2 | 0.923 |
EPHA6 |
0.716 | 0.051 | -1 | 0.871 |
EPHB4 |
0.716 | 0.102 | -1 | 0.859 |
TXK |
0.716 | 0.121 | 1 | 0.862 |
LIMK2_TYR |
0.715 | 0.033 | -3 | 0.849 |
TYRO3 |
0.715 | 0.090 | 3 | 0.778 |
LCK |
0.715 | 0.138 | -1 | 0.863 |
ROS1 |
0.715 | 0.091 | 3 | 0.776 |
CRIK |
0.714 | -0.052 | -3 | 0.614 |
MST1R |
0.714 | 0.113 | 3 | 0.799 |
MAP2K6_TYR |
0.714 | -0.042 | -1 | 0.873 |
MAP2K4_TYR |
0.714 | -0.056 | -1 | 0.873 |
HCK |
0.713 | 0.115 | -1 | 0.863 |
BMPR2_TYR |
0.712 | -0.012 | -1 | 0.873 |
CSF1R |
0.712 | 0.089 | 3 | 0.787 |
PINK1_TYR |
0.711 | -0.081 | 1 | 0.860 |
STLK3 |
0.711 | -0.058 | 1 | 0.746 |
ABL2 |
0.711 | 0.072 | -1 | 0.837 |
LIMK1_TYR |
0.711 | -0.027 | 2 | 0.936 |
PDHK1_TYR |
0.711 | -0.033 | -1 | 0.884 |
RET |
0.711 | 0.053 | 1 | 0.806 |
YES1 |
0.710 | 0.058 | -1 | 0.867 |
TYK2 |
0.710 | 0.031 | 1 | 0.801 |
MERTK |
0.709 | 0.161 | 3 | 0.767 |
EPHB3 |
0.709 | 0.107 | -1 | 0.853 |
AXL |
0.709 | 0.139 | 3 | 0.785 |
FGR |
0.708 | 0.046 | 1 | 0.872 |
JAK2 |
0.708 | 0.038 | 1 | 0.787 |
ITK |
0.707 | 0.072 | -1 | 0.840 |
INSRR |
0.707 | 0.039 | 3 | 0.750 |
ABL1 |
0.707 | 0.061 | -1 | 0.831 |
ALPHAK3 |
0.707 | -0.074 | -1 | 0.764 |
SRMS |
0.706 | 0.046 | 1 | 0.868 |
TNK1 |
0.706 | 0.077 | 3 | 0.756 |
DDR1 |
0.706 | 0.003 | 4 | 0.798 |
EPHB1 |
0.706 | 0.076 | 1 | 0.853 |
JAK3 |
0.705 | 0.047 | 1 | 0.792 |
EPHB2 |
0.705 | 0.072 | -1 | 0.842 |
YANK3 |
0.705 | -0.051 | 2 | 0.470 |
FER |
0.705 | 0.002 | 1 | 0.887 |
AAK1 |
0.705 | 0.035 | 1 | 0.676 |
PDGFRB |
0.705 | 0.033 | 3 | 0.792 |
TNNI3K_TYR |
0.704 | 0.072 | 1 | 0.813 |
EPHA1 |
0.704 | 0.133 | 3 | 0.786 |
KDR |
0.704 | 0.082 | 3 | 0.781 |
TEC |
0.703 | 0.056 | -1 | 0.791 |
JAK1 |
0.703 | 0.092 | 1 | 0.730 |
WEE1_TYR |
0.703 | 0.060 | -1 | 0.772 |
CK1A |
0.703 | -0.075 | -3 | 0.308 |
EPHA4 |
0.702 | 0.016 | 2 | 0.830 |
EPHA7 |
0.702 | 0.081 | 2 | 0.847 |
BMX |
0.701 | 0.041 | -1 | 0.775 |
TEK |
0.701 | 0.026 | 3 | 0.738 |
KIT |
0.700 | 0.015 | 3 | 0.775 |
FYN |
0.700 | 0.070 | -1 | 0.838 |
DDR2 |
0.698 | 0.067 | 3 | 0.747 |
BTK |
0.698 | -0.011 | -1 | 0.819 |
FLT3 |
0.698 | -0.026 | 3 | 0.779 |
LYN |
0.698 | 0.046 | 3 | 0.718 |
PDGFRA |
0.697 | -0.006 | 3 | 0.795 |
FGFR2 |
0.697 | 0.001 | 3 | 0.772 |
LTK |
0.697 | 0.016 | 3 | 0.725 |
MET |
0.696 | 0.016 | 3 | 0.780 |
ALK |
0.696 | -0.002 | 3 | 0.718 |
FGFR1 |
0.695 | 0.009 | 3 | 0.762 |
FRK |
0.695 | 0.031 | -1 | 0.876 |
NTRK1 |
0.694 | -0.004 | -1 | 0.823 |
EPHA3 |
0.693 | 0.002 | 2 | 0.821 |
PTK6 |
0.693 | -0.022 | -1 | 0.762 |
NTRK2 |
0.693 | 0.002 | 3 | 0.768 |
INSR |
0.692 | 0.009 | 3 | 0.738 |
PTK2B |
0.692 | 0.032 | -1 | 0.816 |
NEK10_TYR |
0.692 | -0.041 | 1 | 0.673 |
EPHA5 |
0.691 | 0.048 | 2 | 0.825 |
NTRK3 |
0.690 | 0.016 | -1 | 0.780 |
SRC |
0.690 | 0.019 | -1 | 0.834 |
EPHA8 |
0.689 | 0.033 | -1 | 0.839 |
FLT1 |
0.689 | -0.027 | -1 | 0.824 |
ERBB2 |
0.687 | -0.040 | 1 | 0.758 |
FGFR3 |
0.687 | -0.018 | 3 | 0.761 |
FLT4 |
0.686 | -0.040 | 3 | 0.747 |
MATK |
0.686 | -0.023 | -1 | 0.755 |
EPHA2 |
0.679 | 0.036 | -1 | 0.798 |
MUSK |
0.678 | -0.029 | 1 | 0.663 |
PTK2 |
0.678 | 0.017 | -1 | 0.787 |
EGFR |
0.677 | -0.034 | 1 | 0.665 |
CSK |
0.675 | -0.064 | 2 | 0.851 |
IGF1R |
0.675 | -0.028 | 3 | 0.675 |
YANK2 |
0.674 | -0.074 | 2 | 0.492 |
FGFR4 |
0.674 | -0.029 | -1 | 0.774 |
CK1G3 |
0.673 | -0.092 | -3 | 0.259 |
SYK |
0.673 | -0.029 | -1 | 0.777 |
FES |
0.670 | 0.002 | -1 | 0.742 |
ERBB4 |
0.668 | -0.024 | 1 | 0.684 |
CK1G2 |
0.665 | -0.094 | -3 | 0.355 |
ZAP70 |
0.652 | -0.036 | -1 | 0.710 |