Motif 953 (n=273)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQV5 | None | S27 | ochoa | Eukaryotic translation initiation factor 6 | None |
| A2RTX5 | TARS3 | S675 | ochoa | Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. {ECO:0000250|UniProtKB:Q8BLY2}. |
| E9PCH4 | None | S1462 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| H0YC42 | None | S144 | ochoa | Tumor protein D52 | None |
| K7ERQ8 | None | S30 | ochoa | PCAF N-terminal domain-containing protein | None |
| O00267 | SUPT5H | S789 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00515 | LAD1 | S423 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O00571 | DDX3X | S584 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14733 | MAP2K7 | S265 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14818 | PSMA7 | S30 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O14974 | PPP1R12A | S542 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15061 | SYNM | S1141 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15155 | BET1 | S69 | ochoa | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | Required for vesicular transport from the ER to the Golgi complex (PubMed:34779586). Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250|UniProtKB:Q62896, ECO:0000269|PubMed:34779586}. |
| O15164 | TRIM24 | S802 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15523 | DDX3Y | S101 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43166 | SIPA1L1 | S193 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43290 | SART1 | S591 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43399 | TPD52L2 | S134 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43663 | PRC1 | S494 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O60516 | EIF4EBP3 | S21 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:22684010}. |
| O60716 | CTNND1 | S331 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75469 | NR1I2 | S167 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O94830 | DDHD2 | S183 | ochoa | Triacylglycerol hydrolase DDHD2 (TAG hydrolase) (EC 3.1.1.3) (DDHD domain-containing protein 2) (KIAA0725p) (Phospholipase DDHD2) (EC 3.1.1.-) (SAM, WWE and DDHD domain-containing protein 1) (Triglyceride hydrolase DDHD2) (Triglyceride lipase) | Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system (PubMed:29278326, PubMed:37832604). It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL (By similarity). In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. {ECO:0000250|UniProtKB:Q80Y98, ECO:0000269|PubMed:11788596, ECO:0000269|PubMed:20932832, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:29278326, ECO:0000269|PubMed:37832604}. |
| O95398 | RAPGEF3 | S267 | ochoa | Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}. |
| O95613 | PCNT | S644 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95696 | BRD1 | S814 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95785 | WIZ | S1219 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95817 | BAG3 | S224 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O96017 | CHEK2 | S164 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| O96017 | CHEK2 | S372 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P02461 | COL3A1 | S1320 | ochoa | Collagen alpha-1(III) chain | Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. |
| P02671 | FGA | S22 | psp | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P02810 | PRH1; | S38 | psp | Salivary acidic proline-rich phosphoprotein 1/2 (Db-s) (PRP-1/PRP-2) (Parotid acidic protein) (Pa) (Parotid double-band protein) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) [Cleaved into: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (Db-F) (PIF-F) (PRP-3/PRP-4) (Protein A); Peptide P-C] | PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth. |
| P04083 | ANXA1 | S201 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04150 | NR3C1 | S54 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P04275 | VWF | S1517 | psp | von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| P04280 | PRB1 | S24 | psp | Basic salivary proline-rich protein 1 (Salivary proline-rich protein) [Cleaved into: Proline-rich peptide II-2; Basic peptide IB-6; Peptide P-H] | None |
| P05023 | ATP1A1 | S653 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P06239 | LCK | S71 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P09651 | HNRNPA1 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P10636 | MAPT | S606 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S1539 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P12111 | COL6A3 | S162 | ochoa | Collagen alpha-3(VI) chain | Collagen VI acts as a cell-binding protein. |
| P12277 | CKB | S309 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P13010 | XRCC5 | S175 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13637 | ATP1A3 | S643 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P14625 | HSP90B1 | S403 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15924 | DSP | S32 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16144 | ITGB4 | S1114 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16150 | SPN | S291 | ochoa | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}. |
| P17028 | ZNF24 | S289 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17661 | DES | S72 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P19174 | PLCG1 | S1233 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P19338 | NCL | S580 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P20339 | RAB5A | S29 | ochoa | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P23327 | HRC | S119 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P23327 | HRC | S170 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P23327 | HRC | S358 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P23588 | EIF4B | S263 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23919 | DTYMK | S88 | psp | Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) | Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+). {ECO:0000269|PubMed:12614151, ECO:0000269|PubMed:2017365, ECO:0000269|PubMed:34918187, ECO:0000269|PubMed:8024690, ECO:0000305|PubMed:18469}. |
| P24043 | LAMA2 | S2502 | ochoa | Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P25788 | PSMA3 | S35 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P26639 | TARS1 | S596 | ochoa | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P27816 | MAP4 | S616 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | S937 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29274 | ADORA2A | S335 | ochoa | Adenosine receptor A2a | Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| P30260 | CDC27 | S339 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P30305 | CDC25B | S160 | ochoa | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30305 | CDC25B | S169 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30530 | AXL | S612 | ochoa | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| P31943 | HNRNPH1 | S281 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P32241 | VIPR1 | S250 | psp | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P35613 | BSG | S362 | ochoa | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| P35637 | FUS | S142 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P36952 | SERPINB5 | S316 | psp | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P39023 | RPL3 | S304 | ochoa | Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P45880 | VDAC2 | S243 | ochoa | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P45985 | MAP2K4 | S251 | ochoa | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| P46459 | NSF | S207 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P46821 | MAP1B | S1175 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48742 | LHX1 | S168 | ochoa | LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1) | Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. {ECO:0000269|PubMed:9212161}. |
| P49023 | PXN | S226 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49321 | NASP | S71 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49759 | CLK1 | S337 | ochoa | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}. |
| P49916 | LIG3 | S848 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P51148 | RAB5C | S30 | ochoa | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P52272 | HNRNPM | S468 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52948 | NUP98 | S635 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54578 | USP14 | S456 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P55072 | VCP | S765 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P55795 | HNRNPH2 | S281 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P56537 | EIF6 | S175 | ochoa|psp | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}. |
| P57073 | SOX8 | S184 | ochoa | Transcription factor SOX-8 | Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250|UniProtKB:Q04886}. |
| P60201 | PLP1 | S114 | ochoa | Myelin proteolipid protein (PLP) (Lipophilin) | This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. |
| P60880 | SNAP25 | S154 | ochoa | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) | t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {ECO:0000250|UniProtKB:P60881}. |
| P61020 | RAB5B | S29 | ochoa | Ras-related protein Rab-5B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P62857 | RPS28 | S39 | ochoa | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| P62937 | PPIA | S51 | ochoa | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| P62937 | PPIA | S110 | ochoa | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| P63241 | EIF5A | S46 | ochoa | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| P68104 | EEF1A1 | S291 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P85299 | PRR5 | S288 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| Q00536 | CDK16 | S146 | psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q01804 | OTUD4 | S1049 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q05639 | EEF1A2 | S291 | ochoa | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q05655 | PRKCD | S342 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q07021 | C1QBP | S201 | ochoa | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}. |
| Q09666 | AHNAK | S856 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5321 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5519 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12756 | KIF1A | S932 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12923 | PTPN13 | S890 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13009 | TIAM1 | S368 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13131 | PRKAA1 | S172 | psp | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13228 | SELENBP1 | S371 | ochoa | Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1) | Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250|UniProtKB:Q8VIF7, ECO:0000269|PubMed:29255262}. |
| Q13263 | TRIM28 | S460 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13464 | ROCK1 | S1100 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13501 | SQSTM1 | S180 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13541 | EIF4EBP1 | S35 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13542 | EIF4EBP2 | S25 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q13573 | SNW1 | S446 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13835 | PKP1 | S127 | psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14152 | EIF3A | S1058 | ochoa | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q14247 | CTTN | S109 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14694 | USP10 | S97 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14802 | FXYD3 | S69 | ochoa | FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3) | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}. |
| Q14993 | COL19A1 | S81 | ochoa | Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain) | May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. {ECO:0000269|PubMed:12788917}. |
| Q15047 | SETDB1 | S877 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15124 | PGM5 | S221 | ochoa | Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) | Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). {ECO:0000269|PubMed:8175905}. |
| Q15185 | PTGES3 | S118 | ochoa|psp | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15398 | DLGAP5 | S415 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15633 | TARBP2 | S246 | ochoa | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250|UniProtKB:P97473, ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:11438532, PubMed:12475984, PubMed:2011739). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269|PubMed:11438532, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:2011739, ECO:0000269|PubMed:30626973}. |
| Q15637 | SF1 | S272 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q16566 | CAMK4 | S189 | ochoa | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| Q2M1Z3 | ARHGAP31 | S382 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q32P51 | HNRNPA1L2 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q53T59 | HS1BP3 | S258 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q58FF3 | HSP90B2P | S60 | ochoa | Putative endoplasmin-like protein (Putative heat shock protein 90 kDa beta member 2) | Putative molecular chaperone. {ECO:0000250}. |
| Q5BKX5 | ACTMAP | S318 | ochoa | Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) | Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}. |
| Q5BKZ1 | ZNF326 | S91 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5SZD1 | C6orf141 | S25 | ochoa | Uncharacterized protein C6orf141 | None |
| Q5T0N5 | FNBP1L | S302 | ochoa | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}. |
| Q5T1M5 | FKBP15 | S1130 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T5Y3 | CAMSAP1 | S1080 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5VST9 | OBSCN | S790 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT52 | RPRD2 | S900 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VU43 | PDE4DIP | S736 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VWQ8 | DAB2IP | S289 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q5VZ89 | DENND4C | S1629 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HR2 | TNS2 | S455 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q641Q2 | WASHC2A | S352 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q658Y4 | FAM91A1 | S671 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q68CP9 | ARID2 | S1476 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q68CZ2 | TNS3 | S337 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6P1M3 | LLGL2 | S480 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6P4E1 | GOLM2 | S233 | ochoa | Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) | None |
| Q6PJG2 | MIDEAS | S996 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6TDP4 | KLHL17 | S374 | ochoa | Kelch-like protein 17 (Actinfilin) | Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}. |
| Q6WKZ4 | RAB11FIP1 | S392 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZN55 | ZNF574 | S748 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZV29 | PNPLA7 | S469 | ochoa | Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) | Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). {ECO:0000250|UniProtKB:A2AJ88}. |
| Q709C8 | VPS13C | S3516 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q7Z7C8 | TAF8 | S271 | ochoa | Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250|UniProtKB:Q9EQH4, ECO:0000269|PubMed:14580349, ECO:0000269|PubMed:33795473}. |
| Q8IUD2 | ERC1 | S94 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IVT2 | MISP | S28 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWS0 | PHF6 | S49 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IX01 | SUGP2 | S1042 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IZT6 | ASPM | S565 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N1G2 | CMTR1 | S120 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N2F6 | ARMC10 | S54 | ochoa | Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) | May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}. |
| Q8N4C8 | MINK1 | S175 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N697 | SLC15A4 | S290 | ochoa | Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) | Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}. |
| Q8N697 | SLC15A4 | S291 | ochoa | Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) | Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}. |
| Q8N8Z6 | DCBLD1 | S535 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NB90 | AFG2A | S274 | ochoa | ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q8NF91 | SYNE1 | S8358 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TEU7 | RAPGEF6 | S1412 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WWQ8 | STAB2 | S2352 | ochoa | Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)] | Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:15208308, ECO:0000269|PubMed:15572036, ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18434317, ECO:0000269|PubMed:18573870, ECO:0000269|PubMed:19359419}. |
| Q92900 | UPF1 | S1100 | ochoa | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q92900 | UPF1 | S1107 | ochoa|psp | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q92905 | COPS5 | S201 | psp | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. |
| Q96AE4 | FUBP1 | S99 | ochoa|psp | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96AY4 | TTC28 | S2366 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96C24 | SYTL4 | S509 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96C34 | RUNDC1 | S290 | ochoa | RUN domain-containing protein 1 | May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}. |
| Q96KP4 | CNDP2 | S58 | ochoa | Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase) | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:12473676, PubMed:19346245). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). {ECO:0000250|UniProtKB:Q9D1A2, ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568, ECO:0000269|PubMed:25964343}. |
| Q96RS0 | TGS1 | S438 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96RS0 | TGS1 | S445 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96S90 | LYSMD1 | S168 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q96ST8 | CEP89 | S173 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q96TC7 | RMDN3 | S57 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99575 | POP1 | S76 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q99612 | KLF6 | S192 | ochoa | Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9) | Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. {ECO:0000250}. |
| Q99685 | MGLL | S196 | ochoa | Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) | Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20079333, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842}. |
| Q9BRY0 | SLC39A3 | S125 | ochoa | Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) | Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen. {ECO:0000250|UniProtKB:Q99K24}. |
| Q9BWW4 | SSBP3 | S355 | ochoa | Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) | May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}. |
| Q9BX66 | SORBS1 | S108 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXF6 | RAB11FIP5 | S209 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY44 | EIF2A | S249 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9BZ72 | PITPNM2 | S1324 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9BZE0 | GLIS2 | S245 | psp | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
| Q9C0C2 | TNKS1BP1 | S1248 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZV4 | EIF5A2 | S46 | ochoa | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}. |
| Q9H211 | CDT1 | S150 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H2G2 | SLK | S177 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H334 | FOXP1 | S292 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H694 | BICC1 | S795 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9H6U6 | BCAS3 | S823 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H7N4 | SCAF1 | S846 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HAZ1 | CLK4 | S335 | ochoa | Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}. |
| Q9HCS7 | XAB2 | S751 | ochoa | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). {ECO:0000269|PubMed:10944529, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:17981804, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| Q9NP98 | MYOZ1 | S82 | ochoa | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q9NRH2 | SNRK | S162 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
| Q9NWH9 | SLTM | S929 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NWH9 | SLTM | S944 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NWH9 | SLTM | S1014 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NZT2 | OGFR | S324 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P1Y6 | PHRF1 | S107 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P2N7 | KLHL13 | S50 | ochoa | Kelch-like protein 13 (BTB and kelch domain-containing protein 2) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}. |
| Q9UBS3 | DNAJB9 | S133 | ochoa | DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000250|UniProtKB:Q9QYI6, ECO:0000269|PubMed:18400946}. |
| Q9UJY5 | GGA1 | S317 | ochoa | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}. |
| Q9UKE5 | TNIK | S175 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKJ3 | GPATCH8 | S635 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKM9 | RALY | S63 | ochoa | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9UKX7 | NUP50 | S212 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULF5 | SLC39A10 | S573 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9UN19 | DAPP1 | S137 | ochoa | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
| Q9Y2W1 | THRAP3 | S217 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4L1 | HYOU1 | S964 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9Y6D6 | ARFGEF1 | S394 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| P36871 | PGM1 | S483 | Sugiyama | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P49327 | FASN | S2465 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q9Y230 | RUVBL2 | S43 | Sugiyama | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| Q6DD87 | ZNF787 | S104 | Sugiyama | Zinc finger protein 787 (TTF-I-interacting peptide 20) | May be involved in transcriptional regulation. |
| Q9NY33 | DPP3 | S194 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| P08631 | HCK | S98 | Sugiyama | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P15735 | PHKG2 | S175 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| P52742 | ZNF135 | S308 | Sugiyama | Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1) | Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation. {ECO:0000269|PubMed:21834987}. |
| P60174 | TPI1 | S97 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| Q15056 | EIF4H | S69 | Sugiyama | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q96RR4 | CAMKK2 | S105 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q01518 | CAP1 | S431 | Sugiyama | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q04637 | EIF4G1 | S198 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| P23284 | PPIB | S150 | Sugiyama | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}. |
| P17844 | DDX5 | S519 | Sugiyama | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| A0A2R8Y4L2 | HNRNPA1L3 | S158 | Sugiyama | Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) | None |
| O75122 | CLASP2 | S974 | Sugiyama | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| P10636 | MAPT | S575 | GPS6|ELM|EPSD | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| Q12913 | PTPRJ | S843 | Sugiyama | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}. |
| P22061 | PCMT1 | S132 | Sugiyama | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250|UniProtKB:P23506, ECO:0000269|PubMed:3167043, ECO:0000269|PubMed:6469980}. |
| P10636 | MAPT | S637 | SIGNOR | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| O60701 | UGDH | S392 | Sugiyama | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| Q12802 | AKAP13 | S1253 | Sugiyama | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q9UPQ9 | TNRC6B | S992 | Sugiyama | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| O95747 | OXSR1 | S495 | Sugiyama | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| Q04837 | SSBP1 | S79 | Sugiyama | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}. |
| Q9BTD8 | RBM42 | S372 | Sugiyama | RNA-binding protein 42 (RNA-binding motif protein 42) | Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. {ECO:0000250}. |
| Q15818 | NPTX1 | S93 | Sugiyama | Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I) | May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. {ECO:0000250|UniProtKB:P47971}. |
| Q9NPD3 | EXOSC4 | S78 | Sugiyama | Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}. |
| Q92731 | ESR2 | S165 | GPS6 | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q16531 | DDB1 | S379 | Sugiyama | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMed:16482215, PubMed:16940174, PubMed:17079684). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:38316879}. |
| Q16584 | MAP3K11 | S155 | Sugiyama | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16816 | PHKG1 | S172 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| P33992 | MCM5 | S417 | Sugiyama | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| P43243 | MATR3 | S240 | Sugiyama | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| Q6XUX3 | DSTYK | S58 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q92499 | DDX1 | S113 | Sugiyama | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| P46109 | CRKL | S20 | Sugiyama | Crk-like protein | May mediate the transduction of intracellular signals. |
| P62979 | RPS27A | S115 | Sugiyama | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| Q96EP5 | DAZAP1 | S193 | Sugiyama | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
| Q8NFH4 | NUP37 | S142 | Sugiyama | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) | Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269|PubMed:17363900, ECO:0000269|PubMed:30179222}. |
| O00506 | STK25 | S149 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| Q6P158 | DHX57 | S70 | Sugiyama | Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) | Probable ATP-binding RNA helicase. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.206812e-13 | 12.918 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.678468e-06 | 5.246 |
| R-HSA-2262752 | Cellular responses to stress | 1.443495e-05 | 4.841 |
| R-HSA-72649 | Translation initiation complex formation | 2.773255e-05 | 4.557 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.462165e-05 | 4.461 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.419992e-05 | 4.355 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.419992e-05 | 4.355 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.390626e-05 | 4.470 |
| R-HSA-8953854 | Metabolism of RNA | 3.635054e-05 | 4.439 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.477869e-05 | 4.126 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.526006e-05 | 4.069 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.105294e-04 | 3.957 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.105294e-04 | 3.957 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.233891e-04 | 3.909 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.077705e-04 | 3.682 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.082723e-04 | 3.389 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 6.528689e-04 | 3.185 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 7.374759e-04 | 3.132 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 7.374759e-04 | 3.132 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 9.309420e-04 | 3.031 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 9.309420e-04 | 3.031 |
| R-HSA-162906 | HIV Infection | 9.327621e-04 | 3.030 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 8.300149e-04 | 3.081 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.040721e-03 | 2.983 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.040721e-03 | 2.983 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.159822e-03 | 2.936 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.159822e-03 | 2.936 |
| R-HSA-3371556 | Cellular response to heat stress | 1.167556e-03 | 2.933 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.288721e-03 | 2.890 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.494711e-03 | 2.825 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.912029e-03 | 2.719 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.577852e-03 | 2.802 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.828704e-03 | 2.738 |
| R-HSA-191859 | snRNP Assembly | 1.828704e-03 | 2.738 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.814858e-03 | 2.741 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.739062e-03 | 2.760 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.912029e-03 | 2.719 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.097251e-03 | 2.678 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.097251e-03 | 2.678 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.097251e-03 | 2.678 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.295230e-03 | 2.639 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.606735e-03 | 2.584 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.266277e-03 | 2.486 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.445201e-03 | 2.463 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.494139e-03 | 2.457 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.779263e-03 | 2.423 |
| R-HSA-72172 | mRNA Splicing | 3.794778e-03 | 2.421 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.779263e-03 | 2.423 |
| R-HSA-75153 | Apoptotic execution phase | 3.779263e-03 | 2.423 |
| R-HSA-73893 | DNA Damage Bypass | 4.734391e-03 | 2.325 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.603063e-03 | 2.337 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.338536e-03 | 2.363 |
| R-HSA-168255 | Influenza Infection | 4.677730e-03 | 2.330 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.849599e-03 | 2.233 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.167492e-03 | 2.287 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.849599e-03 | 2.233 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 5.508629e-03 | 2.259 |
| R-HSA-69306 | DNA Replication | 5.508828e-03 | 2.259 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 5.858894e-03 | 2.232 |
| R-HSA-72766 | Translation | 5.481116e-03 | 2.261 |
| R-HSA-9824446 | Viral Infection Pathways | 5.884641e-03 | 2.230 |
| R-HSA-162587 | HIV Life Cycle | 6.364339e-03 | 2.196 |
| R-HSA-6806834 | Signaling by MET | 6.798894e-03 | 2.168 |
| R-HSA-9679506 | SARS-CoV Infections | 6.710577e-03 | 2.173 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.608310e-03 | 2.119 |
| R-HSA-69239 | Synthesis of DNA | 7.775466e-03 | 2.109 |
| R-HSA-211000 | Gene Silencing by RNA | 7.775466e-03 | 2.109 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.444343e-03 | 2.128 |
| R-HSA-109581 | Apoptosis | 7.573439e-03 | 2.121 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 8.099680e-03 | 2.092 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 9.596408e-03 | 2.018 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 9.596408e-03 | 2.018 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.642441e-03 | 2.016 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9.214508e-03 | 2.036 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 9.645993e-03 | 2.016 |
| R-HSA-427975 | Proton/oligopeptide cotransporters | 1.016296e-02 | 1.993 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 9.214508e-03 | 2.036 |
| R-HSA-8948216 | Collagen chain trimerization | 9.957510e-03 | 2.002 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.991941e-03 | 2.000 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 9.993127e-03 | 2.000 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.028562e-02 | 1.988 |
| R-HSA-210991 | Basigin interactions | 1.337664e-02 | 1.874 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.331419e-02 | 1.876 |
| R-HSA-156902 | Peptide chain elongation | 1.062802e-02 | 1.974 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.081133e-02 | 1.966 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.337664e-02 | 1.874 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.331419e-02 | 1.876 |
| R-HSA-8875878 | MET promotes cell motility | 1.073831e-02 | 1.969 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.155760e-02 | 1.937 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.149127e-02 | 1.940 |
| R-HSA-164944 | Nef and signal transduction | 1.270577e-02 | 1.896 |
| R-HSA-69541 | Stabilization of p53 | 1.155760e-02 | 1.937 |
| R-HSA-69242 | S Phase | 1.404055e-02 | 1.853 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.390439e-02 | 1.857 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.171113e-02 | 1.931 |
| R-HSA-8982491 | Glycogen metabolism | 1.241602e-02 | 1.906 |
| R-HSA-2559583 | Cellular Senescence | 1.381995e-02 | 1.859 |
| R-HSA-9607240 | FLT3 Signaling | 1.331419e-02 | 1.876 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.189777e-02 | 1.925 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.477807e-02 | 1.830 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.578171e-02 | 1.802 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.578171e-02 | 1.802 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 1.502545e-02 | 1.823 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.549531e-02 | 1.810 |
| R-HSA-1474290 | Collagen formation | 1.451185e-02 | 1.838 |
| R-HSA-9959399 | SLC-mediated transport of oligopeptides | 1.549531e-02 | 1.810 |
| R-HSA-165159 | MTOR signalling | 1.523212e-02 | 1.817 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.595475e-02 | 1.797 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.545947e-02 | 1.811 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.595475e-02 | 1.797 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.518418e-02 | 1.819 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.625298e-02 | 1.789 |
| R-HSA-8854214 | TBC/RABGAPs | 1.625298e-02 | 1.789 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.625945e-02 | 1.789 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.625945e-02 | 1.789 |
| R-HSA-8951664 | Neddylation | 1.676592e-02 | 1.776 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.852158e-02 | 1.732 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.918592e-02 | 1.717 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.842097e-02 | 1.735 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.842097e-02 | 1.735 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.842097e-02 | 1.735 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.842097e-02 | 1.735 |
| R-HSA-194138 | Signaling by VEGF | 1.751683e-02 | 1.757 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.918592e-02 | 1.717 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.852158e-02 | 1.732 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.852158e-02 | 1.732 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.829957e-02 | 1.738 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.746791e-02 | 1.758 |
| R-HSA-70171 | Glycolysis | 1.928837e-02 | 1.715 |
| R-HSA-429947 | Deadenylation of mRNA | 1.946363e-02 | 1.711 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.946363e-02 | 1.711 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.956902e-02 | 1.708 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.956902e-02 | 1.708 |
| R-HSA-6798695 | Neutrophil degranulation | 1.966411e-02 | 1.706 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.004850e-02 | 1.698 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.076032e-02 | 1.683 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.082876e-02 | 1.681 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.118693e-02 | 1.674 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 2.177490e-02 | 1.662 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.415528e-02 | 1.617 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.459745e-02 | 1.609 |
| R-HSA-5689877 | Josephin domain DUBs | 2.524583e-02 | 1.598 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.282419e-02 | 1.642 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.524583e-02 | 1.598 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 2.524583e-02 | 1.598 |
| R-HSA-9766229 | Degradation of CDH1 | 2.327420e-02 | 1.633 |
| R-HSA-9664873 | Pexophagy | 2.524583e-02 | 1.598 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.245051e-02 | 1.649 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 2.177490e-02 | 1.662 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.327420e-02 | 1.633 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.327420e-02 | 1.633 |
| R-HSA-216083 | Integrin cell surface interactions | 2.403998e-02 | 1.619 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.596530e-02 | 1.586 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.618385e-02 | 1.582 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.892523e-02 | 1.539 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.684255e-02 | 1.571 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.737801e-02 | 1.563 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.883583e-02 | 1.540 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.883583e-02 | 1.540 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.188755e-02 | 1.496 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.844626e-02 | 1.546 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.082893e-02 | 1.511 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.888934e-02 | 1.539 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.684255e-02 | 1.571 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.782014e-02 | 1.556 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.033895e-02 | 1.518 |
| R-HSA-202403 | TCR signaling | 2.879061e-02 | 1.541 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.979380e-02 | 1.526 |
| R-HSA-210990 | PECAM1 interactions | 2.892523e-02 | 1.539 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.101656e-02 | 1.508 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.188755e-02 | 1.496 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.892523e-02 | 1.539 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.079785e-02 | 1.511 |
| R-HSA-5357801 | Programmed Cell Death | 2.767950e-02 | 1.558 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.088755e-02 | 1.510 |
| R-HSA-209560 | NF-kB is activated and signals survival | 3.280419e-02 | 1.484 |
| R-HSA-162592 | Integration of provirus | 3.280419e-02 | 1.484 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 3.280419e-02 | 1.484 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.322384e-02 | 1.479 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.348178e-02 | 1.475 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.373059e-02 | 1.472 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.512177e-02 | 1.454 |
| R-HSA-1640170 | Cell Cycle | 3.561829e-02 | 1.448 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 3.681605e-02 | 1.434 |
| R-HSA-9672393 | Defective F8 binding to von Willebrand factor | 3.681605e-02 | 1.434 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 3.687410e-02 | 1.433 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.284407e-02 | 1.368 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.680760e-02 | 1.434 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.159018e-02 | 1.381 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.032147e-02 | 1.394 |
| R-HSA-354192 | Integrin signaling | 3.787683e-02 | 1.422 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.544392e-02 | 1.343 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.544392e-02 | 1.343 |
| R-HSA-9663891 | Selective autophagy | 3.732139e-02 | 1.428 |
| R-HSA-5205647 | Mitophagy | 4.284407e-02 | 1.368 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.853936e-02 | 1.414 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 3.687410e-02 | 1.433 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 4.555344e-02 | 1.341 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.401041e-02 | 1.356 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 4.032147e-02 | 1.394 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.284407e-02 | 1.368 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4.284407e-02 | 1.368 |
| R-HSA-169911 | Regulation of Apoptosis | 4.544392e-02 | 1.343 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 4.555344e-02 | 1.341 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.885600e-02 | 1.411 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.214076e-02 | 1.375 |
| R-HSA-1442490 | Collagen degradation | 4.214076e-02 | 1.375 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 4.112656e-02 | 1.386 |
| R-HSA-186797 | Signaling by PDGF | 4.401041e-02 | 1.356 |
| R-HSA-435354 | Zinc transporters | 4.555344e-02 | 1.341 |
| R-HSA-74160 | Gene expression (Transcription) | 4.107436e-02 | 1.386 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 4.112656e-02 | 1.386 |
| R-HSA-70326 | Glucose metabolism | 3.853499e-02 | 1.414 |
| R-HSA-913531 | Interferon Signaling | 4.340230e-02 | 1.362 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.082024e-02 | 1.389 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.592600e-02 | 1.338 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 5.471428e-02 | 1.262 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 5.471428e-02 | 1.262 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 5.489905e-02 | 1.260 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 5.980267e-02 | 1.223 |
| R-HSA-9646399 | Aggrephagy | 5.957409e-02 | 1.225 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.837922e-02 | 1.234 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.933600e-02 | 1.307 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.967990e-02 | 1.224 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.098040e-02 | 1.293 |
| R-HSA-3371511 | HSF1 activation | 4.812028e-02 | 1.318 |
| R-HSA-4641258 | Degradation of DVL | 5.087236e-02 | 1.294 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 6.262003e-02 | 1.203 |
| R-HSA-193639 | p75NTR signals via NF-kB | 5.014682e-02 | 1.300 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.812028e-02 | 1.318 |
| R-HSA-4641257 | Degradation of AXIN | 5.087236e-02 | 1.294 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.087236e-02 | 1.294 |
| R-HSA-9612973 | Autophagy | 4.761786e-02 | 1.322 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.650040e-02 | 1.248 |
| R-HSA-111933 | Calmodulin induced events | 4.812028e-02 | 1.318 |
| R-HSA-111997 | CaM pathway | 4.812028e-02 | 1.318 |
| R-HSA-8876725 | Protein methylation | 5.014682e-02 | 1.300 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 5.957409e-02 | 1.225 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.957409e-02 | 1.225 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 6.262003e-02 | 1.203 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.812028e-02 | 1.318 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.151522e-02 | 1.211 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 5.489905e-02 | 1.260 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.660018e-02 | 1.247 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 6.262003e-02 | 1.203 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.787635e-02 | 1.237 |
| R-HSA-69206 | G1/S Transition | 5.016200e-02 | 1.300 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.061341e-02 | 1.217 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.967990e-02 | 1.224 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.812028e-02 | 1.318 |
| R-HSA-9706369 | Negative regulation of FLT3 | 5.489905e-02 | 1.260 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.724170e-02 | 1.326 |
| R-HSA-190236 | Signaling by FGFR | 5.610461e-02 | 1.251 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.289243e-02 | 1.201 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.289243e-02 | 1.201 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.289243e-02 | 1.201 |
| R-HSA-449147 | Signaling by Interleukins | 6.350000e-02 | 1.197 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 6.485047e-02 | 1.188 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 6.485047e-02 | 1.188 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 6.485047e-02 | 1.188 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.521604e-02 | 1.186 |
| R-HSA-192823 | Viral mRNA Translation | 6.528099e-02 | 1.185 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.573697e-02 | 1.182 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 6.573697e-02 | 1.182 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 6.573697e-02 | 1.182 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 6.573697e-02 | 1.182 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.762500e-02 | 1.170 |
| R-HSA-72306 | tRNA processing | 6.762500e-02 | 1.170 |
| R-HSA-111996 | Ca-dependent events | 6.892386e-02 | 1.162 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 6.892386e-02 | 1.162 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.999600e-02 | 1.155 |
| R-HSA-9831926 | Nephron development | 7.003543e-02 | 1.155 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 7.003543e-02 | 1.155 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 7.003543e-02 | 1.155 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.062317e-02 | 1.151 |
| R-HSA-9672391 | Defective F8 cleavage by thrombin | 7.228100e-02 | 1.141 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 7.228100e-02 | 1.141 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 7.228100e-02 | 1.141 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 8.952233e-02 | 1.048 |
| R-HSA-167021 | PLC-gamma1 signalling | 8.952233e-02 | 1.048 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 1.064443e-01 | 0.973 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 1.064443e-01 | 0.973 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 7.535075e-02 | 1.123 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 8.634628e-02 | 1.064 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.022538e-01 | 0.990 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.022538e-01 | 0.990 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.524718e-02 | 1.124 |
| R-HSA-110320 | Translesion Synthesis by POLH | 7.535075e-02 | 1.123 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 8.634628e-02 | 1.064 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 8.234860e-02 | 1.084 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 8.234860e-02 | 1.084 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 8.234860e-02 | 1.084 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 7.889314e-02 | 1.103 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 9.201389e-02 | 1.036 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.934057e-02 | 1.003 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 9.201389e-02 | 1.036 |
| R-HSA-6802949 | Signaling by RAS mutants | 8.234860e-02 | 1.084 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 7.228100e-02 | 1.141 |
| R-HSA-8875513 | MET interacts with TNS proteins | 8.952233e-02 | 1.048 |
| R-HSA-417973 | Adenosine P1 receptors | 8.952233e-02 | 1.048 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.844139e-02 | 1.105 |
| R-HSA-1632852 | Macroautophagy | 7.926252e-02 | 1.101 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.072311e-01 | 0.970 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.186973e-02 | 1.087 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.072311e-01 | 0.970 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 7.535075e-02 | 1.123 |
| R-HSA-68882 | Mitotic Anaphase | 7.911660e-02 | 1.102 |
| R-HSA-6807004 | Negative regulation of MET activity | 8.078983e-02 | 1.093 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.005640e-01 | 0.998 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.741359e-02 | 1.011 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.059381e-02 | 1.094 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.029858e-01 | 0.987 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 8.634628e-02 | 1.064 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 7.550309e-02 | 1.122 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 7.889314e-02 | 1.103 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 8.634628e-02 | 1.064 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.048545e-01 | 0.979 |
| R-HSA-175474 | Assembly Of The HIV Virion | 9.201389e-02 | 1.036 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.823210e-02 | 1.054 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 9.513510e-02 | 1.022 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 7.889314e-02 | 1.103 |
| R-HSA-68886 | M Phase | 8.006048e-02 | 1.097 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.005640e-01 | 0.998 |
| R-HSA-416482 | G alpha (12/13) signalling events | 8.007858e-02 | 1.096 |
| R-HSA-162582 | Signal Transduction | 8.743195e-02 | 1.058 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 8.634628e-02 | 1.064 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 8.634628e-02 | 1.064 |
| R-HSA-5619084 | ABC transporter disorders | 8.007858e-02 | 1.096 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.043859e-01 | 0.981 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.036587e-01 | 0.984 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.069741e-02 | 1.042 |
| R-HSA-3322077 | Glycogen synthesis | 8.078983e-02 | 1.093 |
| R-HSA-3000170 | Syndecan interactions | 1.036587e-01 | 0.984 |
| R-HSA-5663205 | Infectious disease | 8.674925e-02 | 1.062 |
| R-HSA-212436 | Generic Transcription Pathway | 9.043566e-02 | 1.044 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 9.201389e-02 | 1.036 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 9.934057e-02 | 1.003 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.022538e-01 | 0.990 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 8.808714e-02 | 1.055 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.023053e-01 | 0.990 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.297886e-02 | 1.081 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.879279e-02 | 1.005 |
| R-HSA-9675108 | Nervous system development | 1.058211e-01 | 0.975 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.043859e-01 | 0.981 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.791895e-02 | 1.009 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.211815e-02 | 1.142 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.052060e-01 | 0.978 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.081967e-01 | 0.966 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.082644e-01 | 0.966 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.082644e-01 | 0.966 |
| R-HSA-68875 | Mitotic Prophase | 1.097370e-01 | 0.960 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.121981e-01 | 0.950 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.122712e-01 | 0.950 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.142917e-01 | 0.942 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.148336e-01 | 0.940 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.148336e-01 | 0.940 |
| R-HSA-422475 | Axon guidance | 1.154947e-01 | 0.937 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 1.230527e-01 | 0.910 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 1.230527e-01 | 0.910 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 1.230527e-01 | 0.910 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 1.230527e-01 | 0.910 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 1.393535e-01 | 0.856 |
| R-HSA-164525 | Plus-strand DNA synthesis | 1.393535e-01 | 0.856 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.393535e-01 | 0.856 |
| R-HSA-162585 | Uncoating of the HIV Virion | 1.553523e-01 | 0.809 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 1.553523e-01 | 0.809 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.710546e-01 | 0.767 |
| R-HSA-162589 | Reverse Transcription of HIV RNA | 1.864659e-01 | 0.729 |
| R-HSA-164516 | Minus-strand DNA synthesis | 1.864659e-01 | 0.729 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.864659e-01 | 0.729 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.864659e-01 | 0.729 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.864659e-01 | 0.729 |
| R-HSA-8875656 | MET receptor recycling | 1.864659e-01 | 0.729 |
| R-HSA-173107 | Binding and entry of HIV virion | 2.164371e-01 | 0.665 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 2.164371e-01 | 0.665 |
| R-HSA-164843 | 2-LTR circle formation | 2.164371e-01 | 0.665 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 2.164371e-01 | 0.665 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.310074e-01 | 0.636 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.406721e-01 | 0.852 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.470906e-01 | 0.832 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.587335e-01 | 0.799 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.206741e-01 | 0.656 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.548343e-01 | 0.810 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.164371e-01 | 0.665 |
| R-HSA-2424491 | DAP12 signaling | 1.470906e-01 | 0.832 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 2.015917e-01 | 0.696 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.164371e-01 | 0.665 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.799784e-01 | 0.745 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 2.015917e-01 | 0.696 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.723220e-01 | 0.764 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 1.280297e-01 | 0.893 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 1.230527e-01 | 0.910 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 1.230527e-01 | 0.910 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.393535e-01 | 0.856 |
| R-HSA-8849473 | PTK6 Expression | 1.710546e-01 | 0.767 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.864659e-01 | 0.729 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.864659e-01 | 0.729 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.156784e-01 | 0.937 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.002023e-01 | 0.699 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.393535e-01 | 0.856 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.553523e-01 | 0.809 |
| R-HSA-3000157 | Laminin interactions | 1.156784e-01 | 0.937 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.218152e-01 | 0.914 |
| R-HSA-69190 | DNA strand elongation | 1.600993e-01 | 0.796 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.002023e-01 | 0.699 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 2.015917e-01 | 0.696 |
| R-HSA-5689603 | UCH proteinases | 2.100073e-01 | 0.678 |
| R-HSA-202433 | Generation of second messenger molecules | 2.206741e-01 | 0.656 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.406721e-01 | 0.852 |
| R-HSA-187024 | NGF-independant TRKA activation | 1.393535e-01 | 0.856 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.710546e-01 | 0.767 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.710546e-01 | 0.767 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.864659e-01 | 0.729 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 2.015917e-01 | 0.696 |
| R-HSA-176974 | Unwinding of DNA | 2.015917e-01 | 0.696 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.535678e-01 | 0.814 |
| R-HSA-9830364 | Formation of the nephric duct | 1.156784e-01 | 0.937 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.406721e-01 | 0.852 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.406721e-01 | 0.852 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.666810e-01 | 0.778 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.864659e-01 | 0.729 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.310074e-01 | 0.636 |
| R-HSA-8873719 | RAB geranylgeranylation | 1.368864e-01 | 0.864 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.666810e-01 | 0.778 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.033014e-01 | 0.692 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.275378e-01 | 0.643 |
| R-HSA-2025928 | Calcineurin activates NFAT | 2.015917e-01 | 0.696 |
| R-HSA-426048 | Arachidonate production from DAG | 2.164371e-01 | 0.665 |
| R-HSA-1483226 | Synthesis of PI | 2.310074e-01 | 0.636 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.280297e-01 | 0.893 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.600993e-01 | 0.796 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.600993e-01 | 0.796 |
| R-HSA-69481 | G2/M Checkpoints | 1.307833e-01 | 0.883 |
| R-HSA-186763 | Downstream signal transduction | 1.535678e-01 | 0.814 |
| R-HSA-112043 | PLC beta mediated events | 1.411695e-01 | 0.850 |
| R-HSA-73894 | DNA Repair | 1.802098e-01 | 0.744 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.138282e-01 | 0.670 |
| R-HSA-157118 | Signaling by NOTCH | 2.186241e-01 | 0.660 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.976714e-01 | 0.704 |
| R-HSA-381042 | PERK regulates gene expression | 1.866864e-01 | 0.729 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.051965e-01 | 0.688 |
| R-HSA-114608 | Platelet degranulation | 1.307833e-01 | 0.883 |
| R-HSA-69275 | G2/M Transition | 1.899676e-01 | 0.721 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.976714e-01 | 0.704 |
| R-HSA-392499 | Metabolism of proteins | 2.121018e-01 | 0.673 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.901063e-01 | 0.721 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.956294e-01 | 0.709 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.789395e-01 | 0.747 |
| R-HSA-3000178 | ECM proteoglycans | 1.862265e-01 | 0.730 |
| R-HSA-9662001 | Defective factor VIII causes hemophilia A | 1.553523e-01 | 0.809 |
| R-HSA-187015 | Activation of TRKA receptors | 1.710546e-01 | 0.767 |
| R-HSA-9609690 | HCMV Early Events | 2.188867e-01 | 0.660 |
| R-HSA-112040 | G-protein mediated events | 1.677556e-01 | 0.775 |
| R-HSA-73887 | Death Receptor Signaling | 2.232362e-01 | 0.651 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.275378e-01 | 0.643 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.503418e-01 | 0.823 |
| R-HSA-72312 | rRNA processing | 1.975728e-01 | 0.704 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.938772e-01 | 0.712 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.503418e-01 | 0.823 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.503418e-01 | 0.823 |
| R-HSA-1474244 | Extracellular matrix organization | 1.274634e-01 | 0.895 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 2.015917e-01 | 0.696 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.733087e-01 | 0.761 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.434876e-01 | 0.843 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.368864e-01 | 0.864 |
| R-HSA-9711097 | Cellular response to starvation | 1.160873e-01 | 0.935 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.505772e-01 | 0.822 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.644143e-01 | 0.784 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.866864e-01 | 0.729 |
| R-HSA-202424 | Downstream TCR signaling | 1.173950e-01 | 0.930 |
| R-HSA-397014 | Muscle contraction | 1.488858e-01 | 0.827 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.684825e-01 | 0.773 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 1.230527e-01 | 0.910 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.393535e-01 | 0.856 |
| R-HSA-9694493 | Maturation of protein E | 1.393535e-01 | 0.856 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.393535e-01 | 0.856 |
| R-HSA-9683683 | Maturation of protein E | 1.393535e-01 | 0.856 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 1.393535e-01 | 0.856 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.710546e-01 | 0.767 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 2.015917e-01 | 0.696 |
| R-HSA-8874081 | MET activates PTK2 signaling | 1.218152e-01 | 0.914 |
| R-HSA-177929 | Signaling by EGFR | 1.202261e-01 | 0.920 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.587335e-01 | 0.799 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.901063e-01 | 0.721 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.938772e-01 | 0.712 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.198726e-01 | 0.658 |
| R-HSA-450294 | MAP kinase activation | 1.411695e-01 | 0.850 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.356671e-01 | 0.868 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 1.218152e-01 | 0.914 |
| R-HSA-448424 | Interleukin-17 signaling | 1.815588e-01 | 0.741 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.468991e-01 | 0.833 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.864659e-01 | 0.729 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 2.015917e-01 | 0.696 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.218152e-01 | 0.914 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.148430e-01 | 0.668 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.280297e-01 | 0.893 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 1.326491e-01 | 0.877 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 2.015917e-01 | 0.696 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.202261e-01 | 0.920 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.275378e-01 | 0.643 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.498679e-01 | 0.824 |
| R-HSA-8848021 | Signaling by PTK6 | 1.498679e-01 | 0.824 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.815588e-01 | 0.741 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.201893e-01 | 0.920 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.864659e-01 | 0.729 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.498679e-01 | 0.824 |
| R-HSA-5578775 | Ion homeostasis | 1.202261e-01 | 0.920 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.542805e-01 | 0.812 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.070031e-01 | 0.684 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.411695e-01 | 0.850 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.015917e-01 | 0.696 |
| R-HSA-419037 | NCAM1 interactions | 2.002023e-01 | 0.699 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.454971e-01 | 0.837 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.815588e-01 | 0.741 |
| R-HSA-9833482 | PKR-mediated signaling | 2.294864e-01 | 0.639 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.245837e-01 | 0.649 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 1.476750e-01 | 0.831 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.280297e-01 | 0.893 |
| R-HSA-4086400 | PCP/CE pathway | 2.197022e-01 | 0.658 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.470906e-01 | 0.832 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.934288e-01 | 0.713 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.511725e-01 | 0.821 |
| R-HSA-9758941 | Gastrulation | 2.065814e-01 | 0.685 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.310074e-01 | 0.636 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.591173e-01 | 0.798 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.237103e-01 | 0.908 |
| R-HSA-5619102 | SLC transporter disorders | 1.372300e-01 | 0.863 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.327601e-01 | 0.633 |
| R-HSA-9610379 | HCMV Late Events | 2.334187e-01 | 0.632 |
| R-HSA-977225 | Amyloid fiber formation | 2.344091e-01 | 0.630 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.344162e-01 | 0.630 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.344162e-01 | 0.630 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 2.344162e-01 | 0.630 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.344162e-01 | 0.630 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.368422e-01 | 0.626 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.399610e-01 | 0.620 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.407598e-01 | 0.618 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.437307e-01 | 0.613 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.443094e-01 | 0.612 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 2.453077e-01 | 0.610 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 2.453077e-01 | 0.610 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.453077e-01 | 0.610 |
| R-HSA-3000497 | Scavenging by Class H Receptors | 2.453077e-01 | 0.610 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.453077e-01 | 0.610 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.482059e-01 | 0.605 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.482059e-01 | 0.605 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.488221e-01 | 0.604 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.492848e-01 | 0.603 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.492848e-01 | 0.603 |
| R-HSA-9907900 | Proteasome assembly | 2.551117e-01 | 0.593 |
| R-HSA-2172127 | DAP12 interactions | 2.551117e-01 | 0.593 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.551117e-01 | 0.593 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.576633e-01 | 0.589 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.593429e-01 | 0.586 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.593429e-01 | 0.586 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.593429e-01 | 0.586 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 2.593429e-01 | 0.586 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.593429e-01 | 0.586 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.593429e-01 | 0.586 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.593429e-01 | 0.586 |
| R-HSA-69109 | Leading Strand Synthesis | 2.593429e-01 | 0.586 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.593429e-01 | 0.586 |
| R-HSA-69091 | Polymerase switching | 2.593429e-01 | 0.586 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.593429e-01 | 0.586 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.593429e-01 | 0.586 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.593429e-01 | 0.586 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.593429e-01 | 0.586 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.593429e-01 | 0.586 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.593429e-01 | 0.586 |
| R-HSA-5688426 | Deubiquitination | 2.600783e-01 | 0.585 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.620211e-01 | 0.582 |
| R-HSA-9824272 | Somitogenesis | 2.620211e-01 | 0.582 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.642980e-01 | 0.578 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.642980e-01 | 0.578 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.731179e-01 | 0.564 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.731179e-01 | 0.564 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.731179e-01 | 0.564 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.731179e-01 | 0.564 |
| R-HSA-170968 | Frs2-mediated activation | 2.731179e-01 | 0.564 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.731179e-01 | 0.564 |
| R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 2.731179e-01 | 0.564 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.731179e-01 | 0.564 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.758413e-01 | 0.559 |
| R-HSA-597592 | Post-translational protein modification | 2.808752e-01 | 0.551 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.827473e-01 | 0.549 |
| R-HSA-425410 | Metal ion SLC transporters | 2.827473e-01 | 0.549 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.834794e-01 | 0.547 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.866376e-01 | 0.543 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 2.866376e-01 | 0.543 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.866376e-01 | 0.543 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.866376e-01 | 0.543 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.866376e-01 | 0.543 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.866376e-01 | 0.543 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.866376e-01 | 0.543 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.866376e-01 | 0.543 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.866376e-01 | 0.543 |
| R-HSA-6814848 | Glycerophospholipid catabolism | 2.866376e-01 | 0.543 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.866376e-01 | 0.543 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.896475e-01 | 0.538 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 2.896475e-01 | 0.538 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.932566e-01 | 0.533 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.932566e-01 | 0.533 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.999066e-01 | 0.523 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.999066e-01 | 0.523 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 2.999066e-01 | 0.523 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.999066e-01 | 0.523 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.999066e-01 | 0.523 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.999066e-01 | 0.523 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.999066e-01 | 0.523 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.999066e-01 | 0.523 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.999066e-01 | 0.523 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.999066e-01 | 0.523 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.999066e-01 | 0.523 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.999066e-01 | 0.523 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.999066e-01 | 0.523 |
| R-HSA-5676934 | Protein repair | 2.999066e-01 | 0.523 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.999066e-01 | 0.523 |
| R-HSA-9909396 | Circadian clock | 3.024137e-01 | 0.519 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.102921e-01 | 0.508 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.102921e-01 | 0.508 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.129296e-01 | 0.505 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.129296e-01 | 0.505 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.129296e-01 | 0.505 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 3.129296e-01 | 0.505 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.129296e-01 | 0.505 |
| R-HSA-169893 | Prolonged ERK activation events | 3.129296e-01 | 0.505 |
| R-HSA-9708530 | Regulation of BACH1 activity | 3.129296e-01 | 0.505 |
| R-HSA-5635838 | Activation of SMO | 3.129296e-01 | 0.505 |
| R-HSA-9678110 | Attachment and Entry | 3.129296e-01 | 0.505 |
| R-HSA-168249 | Innate Immune System | 3.171274e-01 | 0.499 |
| R-HSA-163685 | Integration of energy metabolism | 3.233959e-01 | 0.490 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.233959e-01 | 0.490 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.251440e-01 | 0.488 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.257111e-01 | 0.487 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.257111e-01 | 0.487 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.257111e-01 | 0.487 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.257111e-01 | 0.487 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.257111e-01 | 0.487 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.257111e-01 | 0.487 |
| R-HSA-1566977 | Fibronectin matrix formation | 3.257111e-01 | 0.487 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 3.257111e-01 | 0.487 |
| R-HSA-70370 | Galactose catabolism | 3.257111e-01 | 0.487 |
| R-HSA-9675151 | Disorders of Developmental Biology | 3.257111e-01 | 0.487 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 3.257111e-01 | 0.487 |
| R-HSA-446728 | Cell junction organization | 3.273489e-01 | 0.485 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.353291e-01 | 0.475 |
| R-HSA-6807070 | PTEN Regulation | 3.360364e-01 | 0.474 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.376153e-01 | 0.472 |
| R-HSA-5654736 | Signaling by FGFR1 | 3.376153e-01 | 0.472 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.382557e-01 | 0.471 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 3.382557e-01 | 0.471 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.382557e-01 | 0.471 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 3.382557e-01 | 0.471 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.382557e-01 | 0.471 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.382557e-01 | 0.471 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.382557e-01 | 0.471 |
| R-HSA-3229121 | Glycogen storage diseases | 3.382557e-01 | 0.471 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.382557e-01 | 0.471 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.382557e-01 | 0.471 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 3.382557e-01 | 0.471 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.455073e-01 | 0.462 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.505676e-01 | 0.455 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.505676e-01 | 0.455 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.505676e-01 | 0.455 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.505676e-01 | 0.455 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.505676e-01 | 0.455 |
| R-HSA-180292 | GAB1 signalosome | 3.505676e-01 | 0.455 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.505676e-01 | 0.455 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 3.505676e-01 | 0.455 |
| R-HSA-5358508 | Mismatch Repair | 3.505676e-01 | 0.455 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.511582e-01 | 0.454 |
| R-HSA-1483255 | PI Metabolism | 3.556716e-01 | 0.449 |
| R-HSA-180786 | Extension of Telomeres | 3.578945e-01 | 0.446 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.578945e-01 | 0.446 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.604951e-01 | 0.443 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 3.626512e-01 | 0.441 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.626512e-01 | 0.441 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.626512e-01 | 0.441 |
| R-HSA-9671793 | Diseases of hemostasis | 3.626512e-01 | 0.441 |
| R-HSA-392517 | Rap1 signalling | 3.626512e-01 | 0.441 |
| R-HSA-449836 | Other interleukin signaling | 3.626512e-01 | 0.441 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.626512e-01 | 0.441 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.626512e-01 | 0.441 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.646053e-01 | 0.438 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.646053e-01 | 0.438 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.646053e-01 | 0.438 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.646053e-01 | 0.438 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.646053e-01 | 0.438 |
| R-HSA-351202 | Metabolism of polyamines | 3.646053e-01 | 0.438 |
| R-HSA-111885 | Opioid Signalling | 3.658156e-01 | 0.437 |
| R-HSA-68877 | Mitotic Prometaphase | 3.664217e-01 | 0.436 |
| R-HSA-168256 | Immune System | 3.681283e-01 | 0.434 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.745107e-01 | 0.427 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 3.745107e-01 | 0.427 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.745107e-01 | 0.427 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.745107e-01 | 0.427 |
| R-HSA-71288 | Creatine metabolism | 3.745107e-01 | 0.427 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 3.745107e-01 | 0.427 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.774868e-01 | 0.423 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.779451e-01 | 0.423 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.779451e-01 | 0.423 |
| R-HSA-166520 | Signaling by NTRKs | 3.782434e-01 | 0.422 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.787058e-01 | 0.422 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.817459e-01 | 0.418 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.836224e-01 | 0.416 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.860182e-01 | 0.413 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.860182e-01 | 0.413 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.861502e-01 | 0.413 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.861502e-01 | 0.413 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.861502e-01 | 0.413 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.861502e-01 | 0.413 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.861502e-01 | 0.413 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.861502e-01 | 0.413 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.861502e-01 | 0.413 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 3.866685e-01 | 0.413 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.879992e-01 | 0.411 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.950793e-01 | 0.403 |
| R-HSA-9609646 | HCMV Infection | 3.952975e-01 | 0.403 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.975739e-01 | 0.401 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.975739e-01 | 0.401 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.975739e-01 | 0.401 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.975739e-01 | 0.401 |
| R-HSA-174403 | Glutathione synthesis and recycling | 3.975739e-01 | 0.401 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 3.975739e-01 | 0.401 |
| R-HSA-9694614 | Attachment and Entry | 3.975739e-01 | 0.401 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.977316e-01 | 0.400 |
| R-HSA-350054 | Notch-HLH transcription pathway | 4.087856e-01 | 0.389 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 4.087856e-01 | 0.389 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 4.087856e-01 | 0.389 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.087856e-01 | 0.389 |
| R-HSA-9669938 | Signaling by KIT in disease | 4.087856e-01 | 0.389 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 4.087856e-01 | 0.389 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 4.087856e-01 | 0.389 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.087856e-01 | 0.389 |
| R-HSA-9830369 | Kidney development | 4.107603e-01 | 0.386 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.107603e-01 | 0.386 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.107603e-01 | 0.386 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.110516e-01 | 0.386 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.172228e-01 | 0.380 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.197894e-01 | 0.377 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 4.197894e-01 | 0.377 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 4.197894e-01 | 0.377 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 4.197894e-01 | 0.377 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.197894e-01 | 0.377 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.259226e-01 | 0.371 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.300395e-01 | 0.366 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.300395e-01 | 0.366 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.300395e-01 | 0.366 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 4.305890e-01 | 0.366 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.305890e-01 | 0.366 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.305890e-01 | 0.366 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.305890e-01 | 0.366 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.305890e-01 | 0.366 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.308511e-01 | 0.366 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.398881e-01 | 0.357 |
| R-HSA-9839394 | TGFBR3 expression | 4.411883e-01 | 0.355 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.411883e-01 | 0.355 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.411883e-01 | 0.355 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.411883e-01 | 0.355 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.411883e-01 | 0.355 |
| R-HSA-2160916 | Hyaluronan degradation | 4.411883e-01 | 0.355 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.411883e-01 | 0.355 |
| R-HSA-109582 | Hemostasis | 4.421010e-01 | 0.354 |
| R-HSA-1500931 | Cell-Cell communication | 4.424993e-01 | 0.354 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.504076e-01 | 0.346 |
| R-HSA-5693538 | Homology Directed Repair | 4.504076e-01 | 0.346 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.515909e-01 | 0.345 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.515909e-01 | 0.345 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.515909e-01 | 0.345 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.515909e-01 | 0.345 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 4.515909e-01 | 0.345 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 4.515909e-01 | 0.345 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.552155e-01 | 0.342 |
| R-HSA-8852135 | Protein ubiquitination | 4.614098e-01 | 0.336 |
| R-HSA-418990 | Adherens junctions interactions | 4.616144e-01 | 0.336 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.618005e-01 | 0.336 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.618005e-01 | 0.336 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.618005e-01 | 0.336 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 4.618005e-01 | 0.336 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.618005e-01 | 0.336 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 4.618005e-01 | 0.336 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.618005e-01 | 0.336 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.618005e-01 | 0.336 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.675629e-01 | 0.330 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.675629e-01 | 0.330 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.718206e-01 | 0.326 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.718206e-01 | 0.326 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 4.718206e-01 | 0.326 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 4.718206e-01 | 0.326 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.718206e-01 | 0.326 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.718206e-01 | 0.326 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.718206e-01 | 0.326 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.744599e-01 | 0.324 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.776794e-01 | 0.321 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.816548e-01 | 0.317 |
| R-HSA-72086 | mRNA Capping | 4.816548e-01 | 0.317 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.816548e-01 | 0.317 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.816548e-01 | 0.317 |
| R-HSA-420092 | Glucagon-type ligand receptors | 4.816548e-01 | 0.317 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.816548e-01 | 0.317 |
| R-HSA-9659379 | Sensory processing of sound | 4.857689e-01 | 0.314 |
| R-HSA-199991 | Membrane Trafficking | 4.876039e-01 | 0.312 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.901886e-01 | 0.310 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.913065e-01 | 0.309 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.913065e-01 | 0.309 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.913065e-01 | 0.309 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.913065e-01 | 0.309 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.913065e-01 | 0.309 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.913065e-01 | 0.309 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.913065e-01 | 0.309 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.913065e-01 | 0.309 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.917514e-01 | 0.308 |
| R-HSA-1643685 | Disease | 4.949987e-01 | 0.305 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.999855e-01 | 0.301 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 5.007790e-01 | 0.300 |
| R-HSA-182971 | EGFR downregulation | 5.007790e-01 | 0.300 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 5.007790e-01 | 0.300 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.007790e-01 | 0.300 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 5.007790e-01 | 0.300 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.026701e-01 | 0.299 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.035841e-01 | 0.298 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.094335e-01 | 0.293 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.100757e-01 | 0.292 |
| R-HSA-9930044 | Nuclear RNA decay | 5.191999e-01 | 0.285 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.191999e-01 | 0.285 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.191999e-01 | 0.285 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.191999e-01 | 0.285 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.191999e-01 | 0.285 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 5.191999e-01 | 0.285 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.191999e-01 | 0.285 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.191999e-01 | 0.285 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.191999e-01 | 0.285 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.191999e-01 | 0.285 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 5.191999e-01 | 0.285 |
| R-HSA-1266738 | Developmental Biology | 5.197820e-01 | 0.284 |
| R-HSA-5576891 | Cardiac conduction | 5.210417e-01 | 0.283 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.255771e-01 | 0.279 |
| R-HSA-390522 | Striated Muscle Contraction | 5.281547e-01 | 0.277 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.281547e-01 | 0.277 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 5.281547e-01 | 0.277 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 5.285451e-01 | 0.277 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.323764e-01 | 0.274 |
| R-HSA-1280218 | Adaptive Immune System | 5.337955e-01 | 0.273 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.369432e-01 | 0.270 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.369432e-01 | 0.270 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 5.369432e-01 | 0.270 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.369432e-01 | 0.270 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.369432e-01 | 0.270 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.369432e-01 | 0.270 |
| R-HSA-5673000 | RAF activation | 5.369432e-01 | 0.270 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 5.369432e-01 | 0.270 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 5.369432e-01 | 0.270 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.379970e-01 | 0.269 |
| R-HSA-1483257 | Phospholipid metabolism | 5.408289e-01 | 0.267 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.435709e-01 | 0.265 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.455686e-01 | 0.263 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.455686e-01 | 0.263 |
| R-HSA-187687 | Signalling to ERKs | 5.455686e-01 | 0.263 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.478936e-01 | 0.261 |
| R-HSA-983712 | Ion channel transport | 5.481032e-01 | 0.261 |
| R-HSA-163560 | Triglyceride catabolism | 5.540338e-01 | 0.256 |
| R-HSA-8853659 | RET signaling | 5.540338e-01 | 0.256 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.540338e-01 | 0.256 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.540338e-01 | 0.256 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.545782e-01 | 0.256 |
| R-HSA-73884 | Base Excision Repair | 5.545782e-01 | 0.256 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.600111e-01 | 0.252 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.600111e-01 | 0.252 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.615698e-01 | 0.251 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.623419e-01 | 0.250 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 5.623419e-01 | 0.250 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.623419e-01 | 0.250 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.704957e-01 | 0.244 |
| R-HSA-9931953 | Biofilm formation | 5.704957e-01 | 0.244 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.707350e-01 | 0.244 |
| R-HSA-421270 | Cell-cell junction organization | 5.754314e-01 | 0.240 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.784981e-01 | 0.238 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.784981e-01 | 0.238 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.784981e-01 | 0.238 |
| R-HSA-201556 | Signaling by ALK | 5.784981e-01 | 0.238 |
| R-HSA-9648002 | RAS processing | 5.784981e-01 | 0.238 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 5.784981e-01 | 0.238 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.812688e-01 | 0.236 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.863518e-01 | 0.232 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.863518e-01 | 0.232 |
| R-HSA-167169 | HIV Transcription Elongation | 5.863518e-01 | 0.232 |
| R-HSA-5260271 | Diseases of Immune System | 5.863518e-01 | 0.232 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.863518e-01 | 0.232 |
| R-HSA-3371568 | Attenuation phase | 5.863518e-01 | 0.232 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.863518e-01 | 0.232 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.864729e-01 | 0.232 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.940597e-01 | 0.226 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.967117e-01 | 0.224 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.967117e-01 | 0.224 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.988580e-01 | 0.223 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 6.016245e-01 | 0.221 |
| R-HSA-6811438 | Intra-Golgi traffic | 6.016245e-01 | 0.221 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 6.016245e-01 | 0.221 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 6.016245e-01 | 0.221 |
| R-HSA-9683701 | Translation of Structural Proteins | 6.016245e-01 | 0.221 |
| R-HSA-157579 | Telomere Maintenance | 6.017639e-01 | 0.221 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.017639e-01 | 0.221 |
| R-HSA-422356 | Regulation of insulin secretion | 6.067683e-01 | 0.217 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6.090487e-01 | 0.215 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 6.090487e-01 | 0.215 |
| R-HSA-3214847 | HATs acetylate histones | 6.117249e-01 | 0.213 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.136051e-01 | 0.212 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.149440e-01 | 0.211 |
| R-HSA-1433557 | Signaling by SCF-KIT | 6.163350e-01 | 0.210 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.163350e-01 | 0.210 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.233822e-01 | 0.205 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.234860e-01 | 0.205 |
| R-HSA-5683826 | Surfactant metabolism | 6.234860e-01 | 0.205 |
| R-HSA-373752 | Netrin-1 signaling | 6.234860e-01 | 0.205 |
| R-HSA-69236 | G1 Phase | 6.234860e-01 | 0.205 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.234860e-01 | 0.205 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.263091e-01 | 0.203 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.305041e-01 | 0.200 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.349545e-01 | 0.197 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.357944e-01 | 0.197 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.373918e-01 | 0.196 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.373918e-01 | 0.196 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.373918e-01 | 0.196 |
| R-HSA-9833110 | RSV-host interactions | 6.404660e-01 | 0.194 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.441516e-01 | 0.191 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.441516e-01 | 0.191 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.496706e-01 | 0.187 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.507857e-01 | 0.187 |
| R-HSA-70263 | Gluconeogenesis | 6.507857e-01 | 0.187 |
| R-HSA-9824439 | Bacterial Infection Pathways | 6.525727e-01 | 0.185 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.636864e-01 | 0.178 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 6.636864e-01 | 0.178 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.699575e-01 | 0.174 |
| R-HSA-9864848 | Complex IV assembly | 6.699575e-01 | 0.174 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.761121e-01 | 0.170 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.761121e-01 | 0.170 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.804074e-01 | 0.167 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.821522e-01 | 0.166 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.821522e-01 | 0.166 |
| R-HSA-1221632 | Meiotic synapsis | 6.821522e-01 | 0.166 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.846148e-01 | 0.165 |
| R-HSA-156588 | Glucuronidation | 6.880801e-01 | 0.162 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.938978e-01 | 0.159 |
| R-HSA-418597 | G alpha (z) signalling events | 6.938978e-01 | 0.159 |
| R-HSA-9753281 | Paracetamol ADME | 6.938978e-01 | 0.159 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.969658e-01 | 0.157 |
| R-HSA-75893 | TNF signaling | 6.996073e-01 | 0.155 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.996073e-01 | 0.155 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.023640e-01 | 0.153 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.024171e-01 | 0.153 |
| R-HSA-1483166 | Synthesis of PA | 7.052107e-01 | 0.152 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.052107e-01 | 0.152 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.057092e-01 | 0.151 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 7.107099e-01 | 0.148 |
| R-HSA-8939211 | ESR-mediated signaling | 7.109733e-01 | 0.148 |
| R-HSA-9033241 | Peroxisomal protein import | 7.161069e-01 | 0.145 |
| R-HSA-8979227 | Triglyceride metabolism | 7.161069e-01 | 0.145 |
| R-HSA-186712 | Regulation of beta-cell development | 7.161069e-01 | 0.145 |
| R-HSA-73886 | Chromosome Maintenance | 7.204688e-01 | 0.142 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.204688e-01 | 0.142 |
| R-HSA-983189 | Kinesins | 7.214034e-01 | 0.142 |
| R-HSA-156590 | Glutathione conjugation | 7.214034e-01 | 0.142 |
| R-HSA-379724 | tRNA Aminoacylation | 7.214034e-01 | 0.142 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.252166e-01 | 0.140 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.279556e-01 | 0.138 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.310505e-01 | 0.136 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.316350e-01 | 0.136 |
| R-HSA-9707616 | Heme signaling | 7.317030e-01 | 0.136 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 7.367095e-01 | 0.133 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 7.367095e-01 | 0.133 |
| R-HSA-373755 | Semaphorin interactions | 7.367095e-01 | 0.133 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.388675e-01 | 0.131 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.388675e-01 | 0.131 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.388675e-01 | 0.131 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.416229e-01 | 0.130 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.424212e-01 | 0.129 |
| R-HSA-4839726 | Chromatin organization | 7.435931e-01 | 0.129 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 7.511773e-01 | 0.124 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.562253e-01 | 0.121 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.574807e-01 | 0.121 |
| R-HSA-167172 | Transcription of the HIV genome | 7.603794e-01 | 0.119 |
| R-HSA-5218859 | Regulated Necrosis | 7.603794e-01 | 0.119 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 7.603794e-01 | 0.119 |
| R-HSA-9843745 | Adipogenesis | 7.628855e-01 | 0.118 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 7.692424e-01 | 0.114 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.777785e-01 | 0.109 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 7.777785e-01 | 0.109 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.791844e-01 | 0.108 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.819278e-01 | 0.107 |
| R-HSA-4086398 | Ca2+ pathway | 7.819278e-01 | 0.107 |
| R-HSA-9749641 | Aspirin ADME | 7.819278e-01 | 0.107 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 7.819278e-01 | 0.107 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.843548e-01 | 0.105 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.859999e-01 | 0.105 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.859999e-01 | 0.105 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.859999e-01 | 0.105 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.869023e-01 | 0.104 |
| R-HSA-380287 | Centrosome maturation | 7.899962e-01 | 0.102 |
| R-HSA-917937 | Iron uptake and transport | 7.899962e-01 | 0.102 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.972161e-01 | 0.098 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.977671e-01 | 0.098 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.015443e-01 | 0.096 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 8.015443e-01 | 0.096 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 8.088892e-01 | 0.092 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.124593e-01 | 0.090 |
| R-HSA-112316 | Neuronal System | 8.125316e-01 | 0.090 |
| R-HSA-1500620 | Meiosis | 8.260875e-01 | 0.083 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 8.260875e-01 | 0.083 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.336539e-01 | 0.079 |
| R-HSA-70268 | Pyruvate metabolism | 8.356567e-01 | 0.078 |
| R-HSA-1989781 | PPARA activates gene expression | 8.360435e-01 | 0.078 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.387284e-01 | 0.076 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.407302e-01 | 0.075 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.447011e-01 | 0.073 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.447011e-01 | 0.073 |
| R-HSA-382551 | Transport of small molecules | 8.475475e-01 | 0.072 |
| R-HSA-195721 | Signaling by WNT | 8.482171e-01 | 0.071 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.532492e-01 | 0.069 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.532492e-01 | 0.069 |
| R-HSA-2029481 | FCGR activation | 8.559931e-01 | 0.068 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.559931e-01 | 0.068 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.586858e-01 | 0.066 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.613284e-01 | 0.065 |
| R-HSA-418555 | G alpha (s) signalling events | 8.721850e-01 | 0.059 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.738203e-01 | 0.059 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.759194e-01 | 0.058 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.759194e-01 | 0.058 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.784971e-01 | 0.056 |
| R-HSA-388396 | GPCR downstream signalling | 8.832365e-01 | 0.054 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.851903e-01 | 0.053 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.860562e-01 | 0.053 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.955388e-01 | 0.048 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.955388e-01 | 0.048 |
| R-HSA-416476 | G alpha (q) signalling events | 9.022974e-01 | 0.045 |
| R-HSA-5617833 | Cilium Assembly | 9.038305e-01 | 0.044 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 9.067370e-01 | 0.043 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.118789e-01 | 0.040 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.118789e-01 | 0.040 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.141721e-01 | 0.039 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.196124e-01 | 0.036 |
| R-HSA-2132295 | MHC class II antigen presentation | 9.242508e-01 | 0.034 |
| R-HSA-6805567 | Keratinization | 9.258013e-01 | 0.033 |
| R-HSA-1474165 | Reproduction | 9.361112e-01 | 0.029 |
| R-HSA-9748784 | Drug ADME | 9.383669e-01 | 0.028 |
| R-HSA-372790 | Signaling by GPCR | 9.422121e-01 | 0.026 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 9.481224e-01 | 0.023 |
| R-HSA-9664417 | Leishmania phagocytosis | 9.481224e-01 | 0.023 |
| R-HSA-9664407 | Parasite infection | 9.481224e-01 | 0.023 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.556516e-01 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 9.569551e-01 | 0.019 |
| R-HSA-2142753 | Arachidonate metabolism | 9.594482e-01 | 0.018 |
| R-HSA-9609507 | Protein localization | 9.602096e-01 | 0.018 |
| R-HSA-418594 | G alpha (i) signalling events | 9.602566e-01 | 0.018 |
| R-HSA-877300 | Interferon gamma signaling | 9.644880e-01 | 0.016 |
| R-HSA-611105 | Respiratory electron transport | 9.757024e-01 | 0.011 |
| R-HSA-9658195 | Leishmania infection | 9.773714e-01 | 0.010 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.773714e-01 | 0.010 |
| R-HSA-3781865 | Diseases of glycosylation | 9.783190e-01 | 0.010 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.791272e-01 | 0.009 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.817266e-01 | 0.008 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.848902e-01 | 0.007 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.909618e-01 | 0.004 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.911323e-01 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.915808e-01 | 0.004 |
| R-HSA-15869 | Metabolism of nucleotides | 9.920903e-01 | 0.003 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.964512e-01 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.966173e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.972912e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.979132e-01 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 9.980789e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.992822e-01 | 0.000 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.993169e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999620e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.901 | 0.255 | 2 | 0.925 |
GCN2 |
0.887 | 0.079 | 2 | 0.840 |
CDC7 |
0.886 | 0.053 | 1 | 0.861 |
DSTYK |
0.885 | 0.118 | 2 | 0.927 |
PRPK |
0.882 | -0.023 | -1 | 0.893 |
MOS |
0.881 | 0.083 | 1 | 0.901 |
ULK2 |
0.881 | -0.011 | 2 | 0.841 |
NEK6 |
0.880 | 0.139 | -2 | 0.907 |
CLK3 |
0.880 | 0.154 | 1 | 0.858 |
BMPR2 |
0.878 | 0.055 | -2 | 0.914 |
MTOR |
0.877 | -0.023 | 1 | 0.782 |
PIM3 |
0.877 | 0.006 | -3 | 0.691 |
PDHK4 |
0.876 | -0.183 | 1 | 0.865 |
NEK7 |
0.876 | 0.037 | -3 | 0.759 |
ATR |
0.875 | 0.028 | 1 | 0.883 |
RAF1 |
0.875 | -0.083 | 1 | 0.854 |
TBK1 |
0.875 | -0.040 | 1 | 0.731 |
TGFBR2 |
0.875 | 0.035 | -2 | 0.812 |
CAMK2G |
0.874 | -0.043 | 2 | 0.870 |
ERK5 |
0.873 | 0.047 | 1 | 0.825 |
CAMK1B |
0.873 | -0.068 | -3 | 0.745 |
CDKL1 |
0.873 | -0.003 | -3 | 0.679 |
IKKB |
0.872 | -0.097 | -2 | 0.769 |
MLK1 |
0.872 | 0.034 | 2 | 0.855 |
NLK |
0.872 | -0.024 | 1 | 0.826 |
WNK1 |
0.872 | 0.008 | -2 | 0.911 |
PDHK1 |
0.872 | -0.149 | 1 | 0.855 |
IKKE |
0.871 | -0.075 | 1 | 0.729 |
CHAK2 |
0.871 | 0.036 | -1 | 0.865 |
FAM20C |
0.871 | 0.160 | 2 | 0.694 |
NDR2 |
0.871 | -0.030 | -3 | 0.687 |
RIPK3 |
0.871 | -0.038 | 3 | 0.785 |
SKMLCK |
0.870 | 0.023 | -2 | 0.871 |
SRPK1 |
0.870 | 0.053 | -3 | 0.614 |
ULK1 |
0.869 | -0.090 | -3 | 0.755 |
GRK5 |
0.869 | -0.081 | -3 | 0.765 |
CDKL5 |
0.868 | 0.017 | -3 | 0.664 |
MARK4 |
0.868 | -0.010 | 4 | 0.851 |
PRKD1 |
0.868 | -0.007 | -3 | 0.669 |
PKCD |
0.868 | 0.058 | 2 | 0.833 |
IRE1 |
0.867 | 0.045 | 1 | 0.899 |
NIK |
0.867 | -0.073 | -3 | 0.764 |
MST4 |
0.867 | 0.015 | 2 | 0.879 |
NEK9 |
0.867 | -0.025 | 2 | 0.874 |
PKN3 |
0.867 | -0.054 | -3 | 0.699 |
IKKA |
0.866 | 0.037 | -2 | 0.764 |
HIPK4 |
0.866 | 0.019 | 1 | 0.845 |
MLK3 |
0.866 | 0.100 | 2 | 0.784 |
RSK2 |
0.866 | -0.019 | -3 | 0.636 |
CAMLCK |
0.865 | -0.058 | -2 | 0.853 |
ATM |
0.865 | 0.071 | 1 | 0.823 |
NUAK2 |
0.865 | -0.051 | -3 | 0.700 |
PKR |
0.864 | 0.154 | 1 | 0.924 |
KIS |
0.864 | 0.034 | 1 | 0.679 |
NDR1 |
0.864 | -0.069 | -3 | 0.686 |
BMPR1B |
0.864 | 0.154 | 1 | 0.805 |
PRKD2 |
0.863 | -0.013 | -3 | 0.618 |
P90RSK |
0.863 | -0.044 | -3 | 0.643 |
MLK2 |
0.863 | -0.008 | 2 | 0.859 |
DAPK2 |
0.863 | -0.078 | -3 | 0.745 |
PIM1 |
0.863 | 0.003 | -3 | 0.633 |
GRK6 |
0.863 | -0.022 | 1 | 0.851 |
CAMK2D |
0.863 | -0.056 | -3 | 0.706 |
BCKDK |
0.862 | -0.140 | -1 | 0.836 |
ANKRD3 |
0.862 | -0.016 | 1 | 0.888 |
IRE2 |
0.862 | 0.063 | 2 | 0.801 |
WNK3 |
0.862 | -0.192 | 1 | 0.859 |
CDK8 |
0.862 | 0.009 | 1 | 0.640 |
MAPKAPK3 |
0.862 | -0.057 | -3 | 0.619 |
GRK4 |
0.862 | -0.032 | -2 | 0.846 |
HUNK |
0.862 | -0.136 | 2 | 0.861 |
SRPK2 |
0.862 | 0.027 | -3 | 0.547 |
TGFBR1 |
0.861 | 0.085 | -2 | 0.810 |
TSSK2 |
0.861 | -0.011 | -5 | 0.898 |
ALK4 |
0.861 | 0.058 | -2 | 0.839 |
GRK1 |
0.861 | 0.014 | -2 | 0.794 |
RSK3 |
0.861 | -0.048 | -3 | 0.643 |
PKN2 |
0.861 | -0.066 | -3 | 0.690 |
TLK2 |
0.860 | 0.117 | 1 | 0.868 |
TSSK1 |
0.860 | 0.004 | -3 | 0.728 |
NIM1 |
0.860 | -0.042 | 3 | 0.787 |
AMPKA1 |
0.859 | -0.074 | -3 | 0.706 |
ICK |
0.859 | -0.030 | -3 | 0.702 |
MLK4 |
0.859 | 0.092 | 2 | 0.768 |
RIPK1 |
0.859 | -0.141 | 1 | 0.878 |
TTBK2 |
0.859 | -0.098 | 2 | 0.773 |
PLK1 |
0.858 | 0.014 | -2 | 0.845 |
PLK3 |
0.858 | 0.107 | 2 | 0.836 |
MASTL |
0.858 | -0.253 | -2 | 0.858 |
LATS2 |
0.857 | -0.072 | -5 | 0.792 |
MAPKAPK2 |
0.857 | -0.023 | -3 | 0.572 |
SMG1 |
0.856 | 0.022 | 1 | 0.842 |
ACVR2A |
0.856 | 0.084 | -2 | 0.809 |
ACVR2B |
0.856 | 0.088 | -2 | 0.817 |
PERK |
0.856 | 0.067 | -2 | 0.855 |
SRPK3 |
0.855 | 0.011 | -3 | 0.601 |
NEK2 |
0.855 | -0.043 | 2 | 0.849 |
PKCB |
0.855 | 0.020 | 2 | 0.776 |
P70S6KB |
0.855 | -0.082 | -3 | 0.663 |
CAMK2B |
0.855 | 0.006 | 2 | 0.840 |
VRK2 |
0.855 | -0.023 | 1 | 0.910 |
CDK19 |
0.854 | -0.002 | 1 | 0.596 |
PKCA |
0.854 | 0.019 | 2 | 0.767 |
ALK2 |
0.854 | 0.077 | -2 | 0.816 |
DLK |
0.854 | -0.197 | 1 | 0.851 |
CHAK1 |
0.853 | -0.042 | 2 | 0.818 |
PAK1 |
0.853 | -0.054 | -2 | 0.777 |
PKACG |
0.853 | -0.079 | -2 | 0.733 |
AMPKA2 |
0.853 | -0.078 | -3 | 0.668 |
DYRK2 |
0.853 | -0.000 | 1 | 0.717 |
PKCG |
0.853 | -0.015 | 2 | 0.784 |
AURC |
0.852 | -0.008 | -2 | 0.639 |
MEK1 |
0.852 | -0.104 | 2 | 0.888 |
MNK2 |
0.852 | -0.039 | -2 | 0.800 |
PKCZ |
0.852 | -0.010 | 2 | 0.823 |
MELK |
0.852 | -0.083 | -3 | 0.658 |
PRKD3 |
0.851 | -0.054 | -3 | 0.607 |
YSK4 |
0.851 | -0.070 | 1 | 0.785 |
PAK3 |
0.851 | -0.103 | -2 | 0.776 |
GRK7 |
0.851 | 0.076 | 1 | 0.770 |
BMPR1A |
0.851 | 0.154 | 1 | 0.784 |
NUAK1 |
0.850 | -0.082 | -3 | 0.657 |
QIK |
0.850 | -0.121 | -3 | 0.703 |
QSK |
0.850 | -0.049 | 4 | 0.827 |
CDK5 |
0.850 | 0.034 | 1 | 0.675 |
LATS1 |
0.850 | -0.017 | -3 | 0.704 |
HRI |
0.849 | -0.056 | -2 | 0.877 |
PKCH |
0.849 | -0.032 | 2 | 0.766 |
CDK13 |
0.849 | -0.011 | 1 | 0.617 |
DNAPK |
0.849 | 0.032 | 1 | 0.734 |
CLK4 |
0.848 | -0.025 | -3 | 0.632 |
JNK3 |
0.848 | 0.021 | 1 | 0.621 |
P38A |
0.848 | 0.022 | 1 | 0.692 |
CDK1 |
0.848 | 0.025 | 1 | 0.603 |
CLK1 |
0.847 | -0.011 | -3 | 0.613 |
BRAF |
0.847 | 0.009 | -4 | 0.853 |
CAMK4 |
0.847 | -0.180 | -3 | 0.680 |
PRP4 |
0.847 | 0.039 | -3 | 0.684 |
JNK2 |
0.847 | 0.034 | 1 | 0.574 |
PINK1 |
0.847 | -0.059 | 1 | 0.883 |
NEK5 |
0.847 | 0.035 | 1 | 0.886 |
PAK6 |
0.847 | -0.030 | -2 | 0.691 |
CAMK2A |
0.847 | -0.056 | 2 | 0.842 |
AURB |
0.846 | -0.033 | -2 | 0.638 |
SIK |
0.846 | -0.072 | -3 | 0.623 |
MSK2 |
0.846 | -0.110 | -3 | 0.597 |
MARK3 |
0.846 | -0.042 | 4 | 0.779 |
TLK1 |
0.846 | -0.010 | -2 | 0.850 |
CHK1 |
0.846 | -0.050 | -3 | 0.702 |
MARK2 |
0.846 | -0.046 | 4 | 0.744 |
WNK4 |
0.845 | -0.034 | -2 | 0.918 |
MEKK2 |
0.845 | 0.046 | 2 | 0.850 |
CDK7 |
0.845 | -0.061 | 1 | 0.649 |
RSK4 |
0.845 | -0.037 | -3 | 0.599 |
MNK1 |
0.845 | -0.053 | -2 | 0.804 |
IRAK4 |
0.844 | -0.029 | 1 | 0.889 |
MEKK1 |
0.844 | -0.037 | 1 | 0.846 |
PAK2 |
0.844 | -0.114 | -2 | 0.763 |
PHKG1 |
0.843 | -0.122 | -3 | 0.675 |
PLK4 |
0.843 | -0.075 | 2 | 0.703 |
P38B |
0.843 | 0.021 | 1 | 0.610 |
CDK18 |
0.843 | 0.001 | 1 | 0.575 |
MPSK1 |
0.843 | 0.069 | 1 | 0.844 |
MYLK4 |
0.842 | -0.099 | -2 | 0.757 |
CLK2 |
0.842 | 0.055 | -3 | 0.614 |
ZAK |
0.842 | -0.054 | 1 | 0.806 |
PIM2 |
0.841 | -0.043 | -3 | 0.612 |
PKACB |
0.841 | -0.030 | -2 | 0.660 |
ERK1 |
0.841 | 0.003 | 1 | 0.592 |
PKG2 |
0.841 | -0.057 | -2 | 0.658 |
CDK2 |
0.841 | -0.038 | 1 | 0.693 |
MEKK3 |
0.841 | -0.104 | 1 | 0.824 |
GRK2 |
0.841 | -0.053 | -2 | 0.721 |
CAMK1G |
0.841 | -0.083 | -3 | 0.634 |
BRSK1 |
0.840 | -0.126 | -3 | 0.651 |
SGK3 |
0.840 | -0.056 | -3 | 0.604 |
AKT2 |
0.840 | -0.046 | -3 | 0.554 |
DCAMKL1 |
0.840 | -0.057 | -3 | 0.633 |
MAPKAPK5 |
0.840 | -0.160 | -3 | 0.585 |
BRSK2 |
0.840 | -0.148 | -3 | 0.675 |
MEK5 |
0.840 | -0.194 | 2 | 0.871 |
MSK1 |
0.840 | -0.077 | -3 | 0.600 |
PLK2 |
0.840 | 0.234 | -3 | 0.897 |
CDK12 |
0.840 | -0.021 | 1 | 0.587 |
P38G |
0.839 | 0.014 | 1 | 0.506 |
SNRK |
0.839 | -0.218 | 2 | 0.750 |
ERK2 |
0.839 | -0.032 | 1 | 0.649 |
MARK1 |
0.839 | -0.096 | 4 | 0.803 |
DRAK1 |
0.839 | -0.108 | 1 | 0.760 |
AURA |
0.838 | -0.038 | -2 | 0.607 |
PKCT |
0.837 | -0.041 | 2 | 0.776 |
TAO3 |
0.837 | 0.008 | 1 | 0.814 |
HIPK1 |
0.837 | -0.021 | 1 | 0.731 |
CDK17 |
0.837 | -0.019 | 1 | 0.515 |
MST3 |
0.836 | -0.039 | 2 | 0.868 |
NEK8 |
0.836 | -0.039 | 2 | 0.862 |
CK1E |
0.836 | -0.081 | -3 | 0.455 |
HIPK2 |
0.836 | -0.003 | 1 | 0.616 |
PRKX |
0.836 | -0.008 | -3 | 0.516 |
CAMKK1 |
0.835 | -0.093 | -2 | 0.783 |
SMMLCK |
0.835 | -0.097 | -3 | 0.691 |
TTBK1 |
0.835 | -0.131 | 2 | 0.698 |
CDK9 |
0.835 | -0.077 | 1 | 0.623 |
DYRK1A |
0.835 | -0.054 | 1 | 0.734 |
CK1G1 |
0.833 | -0.079 | -3 | 0.455 |
PKCI |
0.833 | -0.048 | 2 | 0.788 |
EEF2K |
0.833 | 0.050 | 3 | 0.853 |
CDK3 |
0.833 | 0.015 | 1 | 0.535 |
GAK |
0.833 | 0.010 | 1 | 0.864 |
P38D |
0.833 | 0.025 | 1 | 0.534 |
DCAMKL2 |
0.833 | -0.093 | -3 | 0.672 |
IRAK1 |
0.832 | -0.205 | -1 | 0.831 |
GSK3A |
0.832 | 0.052 | 4 | 0.520 |
GSK3B |
0.832 | 0.006 | 4 | 0.514 |
HIPK3 |
0.831 | -0.062 | 1 | 0.717 |
LKB1 |
0.831 | -0.060 | -3 | 0.736 |
DYRK3 |
0.831 | -0.030 | 1 | 0.750 |
TAO2 |
0.831 | -0.059 | 2 | 0.887 |
MST2 |
0.831 | 0.007 | 1 | 0.821 |
SSTK |
0.830 | -0.090 | 4 | 0.819 |
VRK1 |
0.830 | 0.067 | 2 | 0.896 |
NEK4 |
0.830 | -0.074 | 1 | 0.836 |
DYRK4 |
0.830 | -0.022 | 1 | 0.615 |
DYRK1B |
0.830 | -0.030 | 1 | 0.652 |
TNIK |
0.830 | 0.050 | 3 | 0.880 |
PHKG2 |
0.829 | -0.126 | -3 | 0.662 |
HGK |
0.829 | -0.000 | 3 | 0.878 |
CDK14 |
0.829 | -0.038 | 1 | 0.618 |
CAMK1D |
0.829 | -0.080 | -3 | 0.553 |
AKT1 |
0.829 | -0.052 | -3 | 0.556 |
MINK |
0.828 | 0.000 | 1 | 0.814 |
ERK7 |
0.828 | 0.010 | 2 | 0.565 |
CAMKK2 |
0.828 | -0.133 | -2 | 0.776 |
CK2A2 |
0.828 | 0.044 | 1 | 0.719 |
GRK3 |
0.828 | -0.043 | -2 | 0.672 |
CDK16 |
0.828 | 0.003 | 1 | 0.533 |
P70S6K |
0.827 | -0.117 | -3 | 0.576 |
PKACA |
0.827 | -0.054 | -2 | 0.602 |
CK1D |
0.827 | -0.090 | -3 | 0.398 |
NEK1 |
0.827 | -0.030 | 1 | 0.858 |
PKCE |
0.827 | -0.026 | 2 | 0.764 |
PDK1 |
0.826 | -0.112 | 1 | 0.813 |
PASK |
0.826 | -0.104 | -3 | 0.706 |
DAPK3 |
0.826 | -0.055 | -3 | 0.654 |
PAK5 |
0.825 | -0.083 | -2 | 0.636 |
NEK11 |
0.825 | -0.214 | 1 | 0.801 |
GCK |
0.825 | -0.044 | 1 | 0.809 |
MEKK6 |
0.825 | -0.095 | 1 | 0.836 |
LRRK2 |
0.824 | -0.107 | 2 | 0.891 |
TAK1 |
0.824 | -0.057 | 1 | 0.844 |
JNK1 |
0.823 | -0.002 | 1 | 0.563 |
CK1A2 |
0.822 | -0.104 | -3 | 0.397 |
PAK4 |
0.822 | -0.075 | -2 | 0.639 |
MST1 |
0.821 | -0.061 | 1 | 0.815 |
LOK |
0.821 | -0.073 | -2 | 0.795 |
MAP3K15 |
0.821 | -0.112 | 1 | 0.784 |
BUB1 |
0.820 | 0.054 | -5 | 0.839 |
CDK10 |
0.820 | -0.038 | 1 | 0.605 |
STK33 |
0.820 | -0.113 | 2 | 0.685 |
MEK2 |
0.820 | -0.137 | 2 | 0.858 |
TTK |
0.819 | 0.122 | -2 | 0.855 |
CDK6 |
0.819 | -0.017 | 1 | 0.594 |
PKN1 |
0.819 | -0.100 | -3 | 0.586 |
KHS1 |
0.818 | -0.014 | 1 | 0.797 |
CK2A1 |
0.818 | 0.026 | 1 | 0.695 |
ROCK2 |
0.817 | -0.025 | -3 | 0.629 |
MRCKB |
0.817 | -0.054 | -3 | 0.597 |
YSK1 |
0.817 | -0.050 | 2 | 0.842 |
HPK1 |
0.817 | -0.095 | 1 | 0.788 |
DAPK1 |
0.816 | -0.091 | -3 | 0.640 |
NEK3 |
0.816 | -0.075 | 1 | 0.797 |
MRCKA |
0.816 | -0.065 | -3 | 0.610 |
MOK |
0.816 | 0.002 | 1 | 0.783 |
KHS2 |
0.816 | 0.007 | 1 | 0.804 |
AKT3 |
0.816 | -0.050 | -3 | 0.478 |
PBK |
0.816 | -0.027 | 1 | 0.795 |
SGK1 |
0.815 | -0.050 | -3 | 0.468 |
CHK2 |
0.815 | -0.100 | -3 | 0.497 |
SLK |
0.815 | -0.089 | -2 | 0.746 |
MAK |
0.815 | 0.016 | -2 | 0.749 |
CAMK1A |
0.815 | -0.083 | -3 | 0.513 |
CDK4 |
0.813 | -0.042 | 1 | 0.576 |
RIPK2 |
0.813 | -0.257 | 1 | 0.750 |
MYO3B |
0.813 | 0.052 | 2 | 0.857 |
OSR1 |
0.813 | 0.045 | 2 | 0.838 |
HASPIN |
0.812 | 0.043 | -1 | 0.740 |
PDHK3_TYR |
0.812 | 0.073 | 4 | 0.933 |
DMPK1 |
0.808 | -0.032 | -3 | 0.614 |
SBK |
0.807 | -0.085 | -3 | 0.441 |
MYO3A |
0.806 | -0.009 | 1 | 0.846 |
ROCK1 |
0.804 | -0.054 | -3 | 0.605 |
PKMYT1_TYR |
0.804 | -0.035 | 3 | 0.862 |
TESK1_TYR |
0.804 | -0.094 | 3 | 0.881 |
BIKE |
0.803 | -0.004 | 1 | 0.729 |
ALPHAK3 |
0.803 | -0.002 | -1 | 0.783 |
MAP2K4_TYR |
0.803 | -0.081 | -1 | 0.907 |
BMPR2_TYR |
0.802 | 0.015 | -1 | 0.874 |
PDHK4_TYR |
0.802 | -0.015 | 2 | 0.922 |
PKG1 |
0.802 | -0.102 | -2 | 0.576 |
MAP2K6_TYR |
0.801 | -0.050 | -1 | 0.898 |
MAP2K7_TYR |
0.801 | -0.182 | 2 | 0.909 |
LIMK2_TYR |
0.800 | -0.024 | -3 | 0.771 |
TXK |
0.799 | 0.211 | 1 | 0.838 |
TAO1 |
0.799 | -0.086 | 1 | 0.746 |
PDHK1_TYR |
0.798 | -0.070 | -1 | 0.899 |
ASK1 |
0.798 | -0.161 | 1 | 0.764 |
ABL2 |
0.798 | 0.127 | -1 | 0.849 |
EPHB4 |
0.798 | 0.069 | -1 | 0.851 |
PINK1_TYR |
0.797 | -0.170 | 1 | 0.866 |
EPHA6 |
0.797 | 0.024 | -1 | 0.856 |
TYRO3 |
0.797 | 0.008 | 3 | 0.823 |
RET |
0.796 | -0.023 | 1 | 0.837 |
YES1 |
0.796 | 0.113 | -1 | 0.887 |
CSF1R |
0.796 | 0.059 | 3 | 0.825 |
CRIK |
0.796 | -0.075 | -3 | 0.551 |
ABL1 |
0.795 | 0.111 | -1 | 0.850 |
TYK2 |
0.794 | -0.099 | 1 | 0.834 |
MST1R |
0.794 | -0.059 | 3 | 0.838 |
SRMS |
0.794 | 0.092 | 1 | 0.858 |
LCK |
0.794 | 0.149 | -1 | 0.862 |
LIMK1_TYR |
0.793 | -0.158 | 2 | 0.902 |
HCK |
0.793 | 0.073 | -1 | 0.867 |
BLK |
0.793 | 0.177 | -1 | 0.859 |
ROS1 |
0.792 | -0.040 | 3 | 0.802 |
ITK |
0.792 | 0.087 | -1 | 0.857 |
JAK2 |
0.792 | -0.077 | 1 | 0.821 |
TNK2 |
0.792 | 0.008 | 3 | 0.777 |
FGR |
0.792 | 0.015 | 1 | 0.870 |
STLK3 |
0.789 | -0.141 | 1 | 0.770 |
FER |
0.789 | -0.025 | 1 | 0.878 |
CK1A |
0.789 | -0.110 | -3 | 0.317 |
EPHA4 |
0.789 | 0.011 | 2 | 0.832 |
EPHB2 |
0.788 | 0.077 | -1 | 0.831 |
EPHB1 |
0.788 | 0.022 | 1 | 0.857 |
DDR1 |
0.788 | -0.163 | 4 | 0.842 |
YANK3 |
0.787 | -0.100 | 2 | 0.467 |
PDGFRB |
0.787 | -0.051 | 3 | 0.830 |
MERTK |
0.787 | 0.052 | 3 | 0.802 |
FLT3 |
0.787 | -0.012 | 3 | 0.824 |
TEC |
0.786 | 0.061 | -1 | 0.802 |
INSRR |
0.786 | -0.021 | 3 | 0.769 |
EPHB3 |
0.786 | 0.000 | -1 | 0.837 |
BTK |
0.786 | 0.007 | -1 | 0.840 |
TNNI3K_TYR |
0.785 | 0.007 | 1 | 0.872 |
AAK1 |
0.785 | 0.025 | 1 | 0.620 |
KIT |
0.785 | -0.034 | 3 | 0.820 |
FYN |
0.785 | 0.139 | -1 | 0.827 |
AXL |
0.784 | -0.026 | 3 | 0.799 |
JAK3 |
0.784 | -0.096 | 1 | 0.808 |
TNK1 |
0.784 | -0.051 | 3 | 0.805 |
BMX |
0.783 | 0.028 | -1 | 0.757 |
PTK6 |
0.783 | -0.006 | -1 | 0.801 |
WEE1_TYR |
0.783 | -0.016 | -1 | 0.800 |
LYN |
0.782 | 0.078 | 3 | 0.751 |
KDR |
0.782 | -0.065 | 3 | 0.792 |
JAK1 |
0.781 | -0.039 | 1 | 0.757 |
FGFR2 |
0.781 | -0.102 | 3 | 0.805 |
TEK |
0.780 | -0.110 | 3 | 0.755 |
EPHA7 |
0.780 | 0.008 | 2 | 0.838 |
PDGFRA |
0.780 | -0.120 | 3 | 0.835 |
FRK |
0.780 | 0.028 | -1 | 0.869 |
LTK |
0.779 | -0.044 | 3 | 0.765 |
EPHA1 |
0.778 | -0.022 | 3 | 0.793 |
FGFR1 |
0.778 | -0.113 | 3 | 0.786 |
MET |
0.778 | -0.042 | 3 | 0.805 |
NEK10_TYR |
0.778 | -0.119 | 1 | 0.681 |
NTRK1 |
0.776 | -0.103 | -1 | 0.835 |
ALK |
0.776 | -0.091 | 3 | 0.741 |
PTK2B |
0.775 | 0.016 | -1 | 0.840 |
EPHA3 |
0.775 | -0.081 | 2 | 0.811 |
SRC |
0.774 | 0.052 | -1 | 0.836 |
ERBB2 |
0.773 | -0.104 | 1 | 0.773 |
NTRK2 |
0.773 | -0.113 | 3 | 0.790 |
FLT1 |
0.773 | -0.086 | -1 | 0.827 |
EPHA5 |
0.772 | 0.002 | 2 | 0.823 |
EPHA8 |
0.771 | 0.011 | -1 | 0.803 |
CSK |
0.771 | -0.008 | 2 | 0.839 |
INSR |
0.771 | -0.094 | 3 | 0.750 |
FLT4 |
0.770 | -0.132 | 3 | 0.786 |
MATK |
0.770 | -0.053 | -1 | 0.761 |
FGFR3 |
0.769 | -0.115 | 3 | 0.780 |
DDR2 |
0.769 | -0.071 | 3 | 0.749 |
CK1G3 |
0.768 | -0.121 | -3 | 0.271 |
NTRK3 |
0.768 | -0.095 | -1 | 0.780 |
EGFR |
0.766 | -0.023 | 1 | 0.674 |
PTK2 |
0.765 | 0.028 | -1 | 0.762 |
FGFR4 |
0.763 | -0.035 | -1 | 0.786 |
EPHA2 |
0.760 | -0.027 | -1 | 0.766 |
SYK |
0.759 | 0.006 | -1 | 0.746 |
MUSK |
0.755 | -0.136 | 1 | 0.677 |
YANK2 |
0.754 | -0.130 | 2 | 0.482 |
IGF1R |
0.754 | -0.110 | 3 | 0.684 |
ERBB4 |
0.751 | -0.050 | 1 | 0.688 |
FES |
0.746 | -0.096 | -1 | 0.742 |
CK1G2 |
0.741 | -0.136 | -3 | 0.369 |
ZAP70 |
0.731 | -0.076 | -1 | 0.677 |