Motif 95 (n=151)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E9PAV3 | NACA | S855 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00750 | PIK3C2B | S155 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}. |
| O14686 | KMT2D | S2592 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14813 | PHOX2A | S206 | ochoa|psp | Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) | May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. |
| O15061 | SYNM | S429 | ochoa|psp | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15117 | FYB1 | S391 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15439 | ABCC4 | S638 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O15525 | MAFG | S124 | ochoa|psp | Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF) | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:11154691, PubMed:8932385, PubMed:9421508). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250|UniProtKB:Q76MX4, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}. |
| O43516 | WIPF1 | S340 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O60307 | MAST3 | S782 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O75376 | NCOR1 | S918 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75962 | TRIO | S2370 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O95359 | TACC2 | S2011 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95382 | MAP3K6 | S931 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| O95503 | CBX6 | S301 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| P13378 | HOXD8 | S181 | ochoa | Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P15884 | TCF4 | S198 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P15884 | TCF4 | S481 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P16471 | PRLR | S429 | ochoa | Prolactin receptor (PRL-R) | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}. |
| P20749 | BCL3 | S406 | psp | B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}. |
| P21580 | TNFAIP3 | S453 | ochoa | Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] | Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269|PubMed:14748687, ECO:0000269|PubMed:15258597, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17961127, ECO:0000269|PubMed:18164316, ECO:0000269|PubMed:18952128, ECO:0000269|PubMed:19494296, ECO:0000269|PubMed:22099304, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:8692885, ECO:0000269|PubMed:9299557, ECO:0000269|PubMed:9882303}. |
| P25054 | APC | S1436 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P31629 | HIVEP2 | S565 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P32322 | PYCR1 | S109 | ochoa | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921). {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921, ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:28258219}. |
| P35711 | SOX5 | S414 | ochoa | Transcription factor SOX-5 | Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}. |
| P39880 | CUX1 | S409 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P46013 | MKI67 | S827 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49757 | NUMB | S361 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49796 | RGS3 | S752 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P51617 | IRAK1 | S144 | psp | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P51790 | CLCN3 | S745 | ochoa | H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) | [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). {ECO:0000250|UniProtKB:P51791, ECO:0000303|PubMed:29845874}.; FUNCTION: [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. {ECO:0000269|PubMed:11967229}. |
| P54253 | ATXN1 | S366 | ochoa | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
| P57086 | SCAND1 | S44 | ochoa | SCAN domain-containing protein 1 | May regulate transcriptional activity. |
| P68400 | CSNK2A1 | S362 | psp | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, MRE11, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:28512243, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:16193064, PubMed:22184066). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| P98175 | RBM10 | S531 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q02224 | CENPE | S2639 | ochoa|psp | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q02297 | NRG1 | S515 | ochoa | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)] | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}. |
| Q13506 | NAB1 | S103 | ochoa | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}. |
| Q13625 | TP53BP2 | S354 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14005 | IL16 | S920 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14201 | BTG3 | S169 | ochoa | Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5) | Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase. |
| Q14203 | DCTN1 | S179 | psp | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q15032 | R3HDM1 | S88 | ochoa | R3H domain-containing protein 1 | None |
| Q15746 | MYLK | S1208 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q15797 | SMAD1 | S206 | psp | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q27J81 | INF2 | S419 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2M1Z3 | ARHGAP31 | S1339 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2NKX8 | ERCC6L | S1173 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q4KMQ1 | TPRN | S241 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q4VCS5 | AMOT | S229 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q53ET0 | CRTC2 | S490 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5SVZ6 | ZMYM1 | S387 | ochoa | Zinc finger MYM-type protein 1 | None |
| Q5SW79 | CEP170 | S845 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SYE7 | NHSL1 | S568 | ochoa | NHS-like protein 1 | None |
| Q5T011 | SZT2 | S1651 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T0B9 | ZNF362 | S169 | ochoa | Zinc finger protein 362 | May be involved in transcriptional regulation. |
| Q5T1R4 | HIVEP3 | S1017 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T3J3 | LRIF1 | S176 | ochoa | Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) | Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269|PubMed:17455211, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:32467133}. |
| Q5T5P2 | KIAA1217 | S610 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T5X7 | BEND3 | S710 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5VT52 | RPRD2 | S414 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VWG9 | TAF3 | S498 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
| Q641Q2 | WASHC2A | S441 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68EM7 | ARHGAP17 | S840 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q69YH5 | CDCA2 | S591 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6AI39 | BICRAL | S675 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}. |
| Q6DCA0 | AMMECR1L | S74 | ochoa | AMMECR1-like protein | None |
| Q6P3S6 | FBXO42 | S584 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6P4R8 | NFRKB | S896 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6ZMT4 | KDM7A | S877 | ochoa | Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65) | Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853). {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20622853}. |
| Q70SY1 | CREB3L2 | S234 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q7LDG7 | RASGRP2 | S560 | ochoa | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| Q7Z591 | AKNA | S272 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z6I6 | ARHGAP30 | S332 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86T24 | ZBTB33 | S234 | ochoa | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}. |
| Q86TI0 | TBC1D1 | S695 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86TI2 | DPP9 | S173 | ochoa | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:16475979, ECO:0000269|PubMed:19667070, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29382749, ECO:0000269|PubMed:29967349, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31525884, ECO:0000269|PubMed:32796818, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0000269|PubMed:36112693, ECO:0000269|PubMed:36357533}. |
| Q86UY5 | FAM83A | S357 | ochoa | Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) | Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}. |
| Q86X10 | RALGAPB | S417 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q86XZ4 | SPATS2 | S408 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q86YV5 | PRAG1 | S696 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IWZ8 | SUGP1 | S338 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IYD8 | FANCM | S1758 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IZ21 | PHACTR4 | S344 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8IZP0 | ABI1 | S267 | psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N350 | CBARP | S484 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N3F8 | MICALL1 | S644 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4C8 | MINK1 | S555 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NDX1 | PSD4 | S442 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEB9 | PIK3C3 | S448 | ochoa | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NEM7 | SUPT20H | S492 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NEN9 | PDZD8 | S967 | ochoa | PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. |
| Q8NET4 | RTL9 | S1039 | ochoa | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | None |
| Q8NEZ4 | KMT2C | S2935 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TES7 | FBF1 | S494 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TF74 | WIPF2 | S175 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WUF5 | PPP1R13L | S339 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WWI1 | LMO7 | S407 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXH0 | SYNE2 | S6459 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92545 | TMEM131 | S1202 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q969V6 | MRTFA | S454 | ochoa|psp | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q969V6 | MRTFA | S785 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96A26 | FAM162A | S47 | ochoa | Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P) | Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). {ECO:0000250|UniProtKB:Q9D6U8, ECO:0000269|PubMed:15082785}. |
| Q96AY4 | TTC28 | S2302 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96G01 | BICD1 | S593 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
| Q96G42 | KLHDC7B | S134 | ochoa | Kelch domain-containing protein 7B | None |
| Q96L91 | EP400 | S717 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96PE2 | ARHGEF17 | S332 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q99081 | TCF12 | S208 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99594 | TEAD3 | S145 | ochoa | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q99684 | GFI1 | S98 | ochoa|psp | Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163) | Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020). {ECO:0000250|UniProtKB:P70338, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12778173, ECO:0000269|PubMed:16287849, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:19026687, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:29651020, ECO:0000269|PubMed:8754800}. |
| Q99708 | RBBP8 | S549 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99728 | BARD1 | S391 | ochoa|psp | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
| Q9BTA9 | WAC | S491 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BWN1 | PRR14 | S304 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
| Q9BX66 | SORBS1 | S143 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BZF3 | OSBPL6 | S229 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
| Q9C0D5 | TANC1 | S1497 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0K0 | BCL11B | S358 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H1A4 | ANAPC1 | S202 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H4B6 | SAV1 | S27 | ochoa|psp | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}. |
| Q9H4I2 | ZHX3 | S580 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H5J0 | ZBTB3 | S213 | ochoa | Zinc finger and BTB domain-containing protein 3 | May be involved in transcriptional regulation. |
| Q9H6A9 | PCNX3 | S312 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6R7 | WDCP | S501 | ochoa | WD repeat and coiled-coil-containing protein | None |
| Q9H6S0 | YTHDC2 | S1267 | ochoa | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}. |
| Q9H6S1 | AZI2 | S353 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
| Q9HCM7 | FBRSL1 | S728 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NPC6 | MYOZ2 | S116 | ochoa | Myozenin-2 (Calsarcin-1) (FATZ-related protein 2) | Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q9NQC1 | JADE2 | S672 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
| Q9NR12 | PDLIM7 | Y104 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NX94 | WBP1L | S168 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NZM4 | BICRA | S919 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
| Q9P2B4 | CTTNBP2NL | S563 | ochoa|psp | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9UBU3 | GHRL | S41 | psp | Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin] | [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470}.; FUNCTION: [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470}.; FUNCTION: [Obestatin]: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250}. |
| Q9UGU0 | TCF20 | S1303 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UGU5 | HMGXB4 | S497 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UH99 | SUN2 | S63 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UIF8 | BAZ2B | S533 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UIF8 | BAZ2B | S1594 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UKI8 | TLK1 | S22 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9ULH7 | MRTFB | S209 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9ULK2 | ATXN7L1 | S131 | ochoa | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | None |
| Q9UMS6 | SYNPO2 | S930 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPW6 | SATB2 | S294 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9Y2H9 | MAST1 | S43 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y3Q8 | TSC22D4 | S24 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y5B0 | CTDP1 | S793 | ochoa | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| Q9ULL1 | PLEKHG1 | S615 | Sugiyama | Pleckstrin homology domain-containing family G member 1 | None |
| Q9H9S0 | NANOG | S52 | PSP | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}. |
| P35658 | NUP214 | S661 | Sugiyama | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-4839726 | Chromatin organization | 0.000610 | 3.215 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.001891 | 2.723 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.002724 | 2.565 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.010440 | 1.981 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.020772 | 1.683 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.020772 | 1.683 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.030997 | 1.509 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.051129 | 1.291 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.051129 | 1.291 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.080551 | 1.094 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.014079 | 1.851 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.015677 | 1.805 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.090155 | 1.045 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.017348 | 1.761 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.099659 | 1.001 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.099659 | 1.001 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.099659 | 1.001 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.026756 | 1.573 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.028837 | 1.540 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.028837 | 1.540 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.028837 | 1.540 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.028837 | 1.540 |
| R-HSA-4839744 | Signaling by APC mutants | 0.136700 | 0.864 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.136700 | 0.864 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.136700 | 0.864 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.136700 | 0.864 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.145721 | 0.836 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.145721 | 0.836 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.042579 | 1.371 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.154648 | 0.811 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.154648 | 0.811 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.154648 | 0.811 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.154648 | 0.811 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.154648 | 0.811 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.154648 | 0.811 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.154648 | 0.811 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.163483 | 0.787 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.052836 | 1.277 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.055525 | 1.256 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.172226 | 0.764 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.058260 | 1.235 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.058260 | 1.235 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.180877 | 0.743 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.063868 | 1.195 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.063868 | 1.195 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.066738 | 1.176 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.189439 | 0.723 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.189439 | 0.723 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.072603 | 1.139 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.197912 | 0.704 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.197912 | 0.704 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.032933 | 1.482 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.084803 | 1.072 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.087944 | 1.056 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.222807 | 0.652 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.222807 | 0.652 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.230933 | 0.637 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.238975 | 0.622 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.077300 | 1.112 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.077300 | 1.112 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.292974 | 0.533 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.292974 | 0.533 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.300371 | 0.522 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.300371 | 0.522 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.300371 | 0.522 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.171438 | 0.766 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.171438 | 0.766 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.182646 | 0.738 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.209177 | 0.679 |
| R-HSA-380287 | Centrosome maturation | 0.216832 | 0.664 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.270885 | 0.567 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.239929 | 0.620 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.243793 | 0.613 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.012556 | 1.901 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.087045 | 1.060 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.182906 | 0.738 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.182906 | 0.738 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.182906 | 0.738 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.081697 | 1.088 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.197751 | 0.704 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.300371 | 0.522 |
| R-HSA-167172 | Transcription of the HIV genome | 0.190178 | 0.721 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.069650 | 1.157 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.017348 | 1.761 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.209177 | 0.679 |
| R-HSA-4641265 | Repression of WNT target genes | 0.154648 | 0.811 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.030286 | 1.519 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.084803 | 1.072 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.055525 | 1.256 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.063868 | 1.195 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.206297 | 0.686 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.061042 | 1.214 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.125956 | 0.900 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.066738 | 1.176 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.034726 | 1.459 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.034726 | 1.459 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.197912 | 0.704 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.213001 | 0.672 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.063868 | 1.195 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.022790 | 1.642 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.026756 | 1.573 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.186407 | 0.730 |
| R-HSA-2028269 | Signaling by Hippo | 0.022790 | 1.642 |
| R-HSA-201451 | Signaling by BMP | 0.292974 | 0.533 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.270469 | 0.568 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.160353 | 0.795 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.145721 | 0.836 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.145721 | 0.836 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.145721 | 0.836 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.145721 | 0.836 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.163483 | 0.787 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.069650 | 1.157 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.197912 | 0.704 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.197912 | 0.704 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.078628 | 1.104 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.078628 | 1.104 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.214595 | 0.668 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.107476 | 0.969 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.254809 | 0.594 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.089128 | 1.050 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.297955 | 0.526 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.052836 | 1.277 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.040146 | 1.396 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.314934 | 0.502 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.142202 | 0.847 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.180877 | 0.743 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.099659 | 1.001 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.066738 | 1.176 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.081697 | 1.088 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.292974 | 0.533 |
| R-HSA-9707616 | Heme signaling | 0.167729 | 0.775 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.135074 | 0.869 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.190178 | 0.721 |
| R-HSA-68877 | Mitotic Prometaphase | 0.073919 | 1.131 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.056069 | 1.251 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.020907 | 1.680 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.145721 | 0.836 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.172226 | 0.764 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.197912 | 0.704 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.238975 | 0.622 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.238975 | 0.622 |
| R-HSA-191859 | snRNP Assembly | 0.156688 | 0.805 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.156688 | 0.805 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.164033 | 0.785 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.314934 | 0.502 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.209177 | 0.679 |
| R-HSA-162587 | HIV Life Cycle | 0.113613 | 0.945 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.251527 | 0.599 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.231341 | 0.636 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.169980 | 0.770 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.285500 | 0.544 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.228585 | 0.641 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.228585 | 0.641 |
| R-HSA-9664407 | Parasite infection | 0.228585 | 0.641 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.118373 | 0.927 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.055525 | 1.256 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.172226 | 0.764 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.069650 | 1.157 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.072603 | 1.139 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.292974 | 0.533 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.273296 | 0.563 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.043730 | 1.359 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.204104 | 0.690 |
| R-HSA-5689603 | UCH proteinases | 0.059386 | 1.226 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.062927 | 1.201 |
| R-HSA-162906 | HIV Infection | 0.261621 | 0.582 |
| R-HSA-195721 | Signaling by WNT | 0.243024 | 0.614 |
| R-HSA-416476 | G alpha (q) signalling events | 0.179956 | 0.745 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.070846 | 1.150 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.012556 | 1.901 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.099659 | 1.001 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.004444 | 2.352 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.004444 | 2.352 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.118373 | 0.927 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.145721 | 0.836 |
| R-HSA-9839394 | TGFBR3 expression | 0.042579 | 1.371 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.154648 | 0.811 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.087944 | 1.056 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.087944 | 1.056 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.091119 | 1.040 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.213001 | 0.672 |
| R-HSA-68882 | Mitotic Anaphase | 0.104258 | 0.982 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.105640 | 0.976 |
| R-HSA-3214842 | HDMs demethylate histones | 0.277947 | 0.556 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.091119 | 1.040 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.055525 | 1.256 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.006396 | 2.194 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.011514 | 1.939 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.087944 | 1.056 |
| R-HSA-9675135 | Diseases of DNA repair | 0.110837 | 0.955 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.014079 | 1.851 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.154648 | 0.811 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.154648 | 0.811 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.154648 | 0.811 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.180877 | 0.743 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.063868 | 1.195 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.066738 | 1.176 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.081697 | 1.088 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.110837 | 0.955 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.246933 | 0.607 |
| R-HSA-3214847 | HATs acetylate histones | 0.110176 | 0.958 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.205360 | 0.687 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.135384 | 0.868 |
| R-HSA-68886 | M Phase | 0.063532 | 1.197 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.090155 | 1.045 |
| R-HSA-1500620 | Meiosis | 0.075412 | 1.123 |
| R-HSA-449836 | Other interleukin signaling | 0.222807 | 0.652 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.313362 | 0.504 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.084803 | 1.072 |
| R-HSA-1221632 | Meiotic synapsis | 0.135074 | 0.869 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.285500 | 0.544 |
| R-HSA-9909396 | Circadian clock | 0.204104 | 0.690 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.292974 | 0.533 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.276165 | 0.559 |
| R-HSA-5688426 | Deubiquitination | 0.071177 | 1.148 |
| R-HSA-2559583 | Cellular Senescence | 0.059822 | 1.223 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.018446 | 1.734 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.230933 | 0.637 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.149409 | 0.826 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.246933 | 0.607 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.199343 | 0.700 |
| R-HSA-1640170 | Cell Cycle | 0.083521 | 1.078 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.127584 | 0.894 |
| R-HSA-525793 | Myogenesis | 0.045066 | 1.346 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.030482 | 1.516 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.206297 | 0.686 |
| R-HSA-392517 | Rap1 signalling | 0.222807 | 0.652 |
| R-HSA-73887 | Death Receptor Signaling | 0.010066 | 1.997 |
| R-HSA-9620244 | Long-term potentiation | 0.277947 | 0.556 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.167729 | 0.775 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.175118 | 0.757 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.091119 | 1.040 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.050201 | 1.299 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.072603 | 1.139 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.018445 | 1.734 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.074110 | 1.130 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.075596 | 1.122 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.116858 | 0.932 |
| R-HSA-74160 | Gene expression (Transcription) | 0.196581 | 0.706 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.118474 | 0.926 |
| R-HSA-1474165 | Reproduction | 0.019580 | 1.708 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.069650 | 1.157 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.197912 | 0.704 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.132115 | 0.879 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.117638 | 0.929 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.142616 | 0.846 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.089128 | 1.050 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.022790 | 1.642 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.254809 | 0.594 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.314934 | 0.502 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.286616 | 0.543 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.127584 | 0.894 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.172226 | 0.764 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.196086 | 0.708 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.199343 | 0.700 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.285500 | 0.544 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.160353 | 0.795 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.118834 | 0.925 |
| R-HSA-2262752 | Cellular responses to stress | 0.080577 | 1.094 |
| R-HSA-445144 | Signal transduction by L1 | 0.230933 | 0.637 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.285500 | 0.544 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.121422 | 0.916 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.057350 | 1.241 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.110837 | 0.955 |
| R-HSA-9758941 | Gastrulation | 0.256390 | 0.591 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.164887 | 0.783 |
| R-HSA-162582 | Signal Transduction | 0.050744 | 1.295 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.205360 | 0.687 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.130660 | 0.884 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.165188 | 0.782 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.277947 | 0.556 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.220669 | 0.656 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.167729 | 0.775 |
| R-HSA-212436 | Generic Transcription Pathway | 0.101214 | 0.995 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.066738 | 1.176 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.197751 | 0.704 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.130660 | 0.884 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.180877 | 0.743 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.062794 | 1.202 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.250579 | 0.601 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.216832 | 0.664 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.011755 | 1.930 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.084803 | 1.072 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.054444 | 1.264 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.144519 | 0.840 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.144519 | 0.840 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.225837 | 0.646 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.292974 | 0.533 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.251527 | 0.599 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.077410 | 1.111 |
| R-HSA-9675108 | Nervous system development | 0.300459 | 0.522 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.237223 | 0.625 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.175162 | 0.757 |
| R-HSA-418990 | Adherens junctions interactions | 0.107030 | 0.970 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.270469 | 0.568 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.300371 | 0.522 |
| R-HSA-421270 | Cell-cell junction organization | 0.157695 | 0.802 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.089054 | 1.050 |
| R-HSA-1500931 | Cell-Cell communication | 0.143793 | 0.842 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.171438 | 0.766 |
| R-HSA-8848021 | Signaling by PTK6 | 0.171438 | 0.766 |
| R-HSA-446728 | Cell junction organization | 0.205159 | 0.688 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.262602 | 0.581 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.307691 | 0.512 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.214595 | 0.668 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.239929 | 0.620 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.254809 | 0.594 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.263140 | 0.580 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.286365 | 0.543 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.322103 | 0.492 |
| R-HSA-70171 | Glycolysis | 0.324871 | 0.488 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.329196 | 0.483 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.329196 | 0.483 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.329196 | 0.483 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.329410 | 0.482 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.330270 | 0.481 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.331540 | 0.479 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.332517 | 0.478 |
| R-HSA-1483255 | PI Metabolism | 0.332517 | 0.478 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.336216 | 0.473 |
| R-HSA-9930044 | Nuclear RNA decay | 0.336216 | 0.473 |
| R-HSA-9733709 | Cardiogenesis | 0.336216 | 0.473 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.336216 | 0.473 |
| R-HSA-354192 | Integrin signaling | 0.336216 | 0.473 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.336216 | 0.473 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.343163 | 0.464 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.343163 | 0.464 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.343163 | 0.464 |
| R-HSA-168255 | Influenza Infection | 0.344552 | 0.463 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.345998 | 0.461 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.347733 | 0.459 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.348792 | 0.457 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.350038 | 0.456 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.350038 | 0.456 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.350038 | 0.456 |
| R-HSA-5205647 | Mitophagy | 0.350038 | 0.456 |
| R-HSA-211000 | Gene Silencing by RNA | 0.355299 | 0.449 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.359071 | 0.445 |
| R-HSA-8853659 | RET signaling | 0.363573 | 0.439 |
| R-HSA-73894 | DNA Repair | 0.368796 | 0.433 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.374075 | 0.427 |
| R-HSA-5617833 | Cilium Assembly | 0.375864 | 0.425 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.381524 | 0.418 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.383353 | 0.416 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.383353 | 0.416 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.383353 | 0.416 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.383353 | 0.416 |
| R-HSA-422475 | Axon guidance | 0.383892 | 0.416 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.383935 | 0.416 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.388937 | 0.410 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.389809 | 0.409 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.389809 | 0.409 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.389809 | 0.409 |
| R-HSA-167169 | HIV Transcription Elongation | 0.389809 | 0.409 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.389809 | 0.409 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.389809 | 0.409 |
| R-HSA-202433 | Generation of second messenger molecules | 0.389809 | 0.409 |
| R-HSA-9609690 | HCMV Early Events | 0.392828 | 0.406 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.396198 | 0.402 |
| R-HSA-373760 | L1CAM interactions | 0.396310 | 0.402 |
| R-HSA-70326 | Glucose metabolism | 0.399981 | 0.398 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.399981 | 0.398 |
| R-HSA-167161 | HIV Transcription Initiation | 0.402521 | 0.395 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.402521 | 0.395 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.402521 | 0.395 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.402521 | 0.395 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.402521 | 0.395 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.402521 | 0.395 |
| R-HSA-5693538 | Homology Directed Repair | 0.403642 | 0.394 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.403642 | 0.394 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.408778 | 0.389 |
| R-HSA-68875 | Mitotic Prophase | 0.410932 | 0.386 |
| R-HSA-3371556 | Cellular response to heat stress | 0.414561 | 0.382 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.414969 | 0.382 |
| R-HSA-373752 | Netrin-1 signaling | 0.421097 | 0.376 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.421097 | 0.376 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.421097 | 0.376 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.421786 | 0.375 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.425381 | 0.371 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.427160 | 0.369 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.427160 | 0.369 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.427160 | 0.369 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.433160 | 0.363 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.433160 | 0.363 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.433160 | 0.363 |
| R-HSA-75153 | Apoptotic execution phase | 0.433160 | 0.363 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.439098 | 0.357 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.439098 | 0.357 |
| R-HSA-437239 | Recycling pathway of L1 | 0.439098 | 0.357 |
| R-HSA-1483191 | Synthesis of PC | 0.439098 | 0.357 |
| R-HSA-69481 | G2/M Checkpoints | 0.439645 | 0.357 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.443181 | 0.353 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.444974 | 0.352 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.450789 | 0.346 |
| R-HSA-109704 | PI3K Cascade | 0.456543 | 0.341 |
| R-HSA-9748787 | Azathioprine ADME | 0.456543 | 0.341 |
| R-HSA-9843745 | Adipogenesis | 0.457202 | 0.340 |
| R-HSA-912446 | Meiotic recombination | 0.462238 | 0.335 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.467873 | 0.330 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.467873 | 0.330 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.467873 | 0.330 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.473449 | 0.325 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.473449 | 0.325 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.473449 | 0.325 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.473449 | 0.325 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.473449 | 0.325 |
| R-HSA-72649 | Translation initiation complex formation | 0.478967 | 0.320 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.478967 | 0.320 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.478967 | 0.320 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.484428 | 0.315 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.484428 | 0.315 |
| R-HSA-9753281 | Paracetamol ADME | 0.484428 | 0.315 |
| R-HSA-6807070 | PTEN Regulation | 0.487993 | 0.312 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.489832 | 0.310 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.489832 | 0.310 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.489832 | 0.310 |
| R-HSA-75893 | TNF signaling | 0.489832 | 0.310 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.489832 | 0.310 |
| R-HSA-177929 | Signaling by EGFR | 0.489832 | 0.310 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.489832 | 0.310 |
| R-HSA-1632852 | Macroautophagy | 0.494687 | 0.306 |
| R-HSA-112399 | IRS-mediated signalling | 0.495179 | 0.305 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.500471 | 0.301 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.500471 | 0.301 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.500471 | 0.301 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.505707 | 0.296 |
| R-HSA-983189 | Kinesins | 0.510890 | 0.292 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.510890 | 0.292 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.510890 | 0.292 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.510890 | 0.292 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.510890 | 0.292 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.510890 | 0.292 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.510890 | 0.292 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.516018 | 0.287 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.516018 | 0.287 |
| R-HSA-450294 | MAP kinase activation | 0.516018 | 0.287 |
| R-HSA-166520 | Signaling by NTRKs | 0.520907 | 0.283 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.521092 | 0.283 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.521092 | 0.283 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.521092 | 0.283 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.530504 | 0.275 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.531083 | 0.275 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.531083 | 0.275 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.536001 | 0.271 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.536001 | 0.271 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.536830 | 0.270 |
| R-HSA-9609646 | HCMV Infection | 0.540189 | 0.267 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.545683 | 0.263 |
| R-HSA-9612973 | Autophagy | 0.546209 | 0.263 |
| R-HSA-9610379 | HCMV Late Events | 0.549306 | 0.260 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.550448 | 0.259 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.550448 | 0.259 |
| R-HSA-9711097 | Cellular response to starvation | 0.552389 | 0.258 |
| R-HSA-448424 | Interleukin-17 signaling | 0.559830 | 0.252 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.564448 | 0.248 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.564448 | 0.248 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.564448 | 0.248 |
| R-HSA-109581 | Apoptosis | 0.564570 | 0.248 |
| R-HSA-1280218 | Adaptive Immune System | 0.568372 | 0.245 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.569017 | 0.245 |
| R-HSA-4086398 | Ca2+ pathway | 0.573539 | 0.241 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.573539 | 0.241 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.578014 | 0.238 |
| R-HSA-5619102 | SLC transporter disorders | 0.579462 | 0.237 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.582442 | 0.235 |
| R-HSA-8852135 | Protein ubiquitination | 0.582442 | 0.235 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.583894 | 0.234 |
| R-HSA-72306 | tRNA processing | 0.591106 | 0.228 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.591160 | 0.228 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.595451 | 0.225 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.595451 | 0.225 |
| R-HSA-1266738 | Developmental Biology | 0.596038 | 0.225 |
| R-HSA-9659379 | Sensory processing of sound | 0.599698 | 0.222 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.603900 | 0.219 |
| R-HSA-9833482 | PKR-mediated signaling | 0.603900 | 0.219 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.605324 | 0.218 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.605324 | 0.218 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.612172 | 0.213 |
| R-HSA-9658195 | Leishmania infection | 0.613787 | 0.212 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.613787 | 0.212 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.616244 | 0.210 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.620273 | 0.207 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.624260 | 0.205 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.624260 | 0.205 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.628206 | 0.202 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.632110 | 0.199 |
| R-HSA-69275 | G2/M Transition | 0.635287 | 0.197 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.635974 | 0.197 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.635974 | 0.197 |
| R-HSA-156902 | Peptide chain elongation | 0.639797 | 0.194 |
| R-HSA-9663891 | Selective autophagy | 0.639797 | 0.194 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.640540 | 0.193 |
| R-HSA-983712 | Ion channel transport | 0.643145 | 0.192 |
| R-HSA-1483257 | Phospholipid metabolism | 0.644343 | 0.191 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.648310 | 0.188 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.650870 | 0.187 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.651029 | 0.186 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.654695 | 0.184 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.655947 | 0.183 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.658323 | 0.182 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.658323 | 0.182 |
| R-HSA-391251 | Protein folding | 0.658323 | 0.182 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.658323 | 0.182 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.661913 | 0.179 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.668980 | 0.175 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.668980 | 0.175 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.672459 | 0.172 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.672459 | 0.172 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.675901 | 0.170 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.675901 | 0.170 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.675901 | 0.170 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.678069 | 0.169 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.679307 | 0.168 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.682678 | 0.166 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.682678 | 0.166 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.682678 | 0.166 |
| R-HSA-72172 | mRNA Splicing | 0.682826 | 0.166 |
| R-HSA-5357801 | Programmed Cell Death | 0.685182 | 0.164 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.686013 | 0.164 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.689314 | 0.162 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.689314 | 0.162 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.692580 | 0.160 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.692580 | 0.160 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.695812 | 0.158 |
| R-HSA-192823 | Viral mRNA Translation | 0.699010 | 0.156 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.700259 | 0.155 |
| R-HSA-397014 | Muscle contraction | 0.701284 | 0.154 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.702175 | 0.154 |
| R-HSA-199991 | Membrane Trafficking | 0.707429 | 0.150 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.708405 | 0.150 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.711472 | 0.148 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.714506 | 0.146 |
| R-HSA-69239 | Synthesis of DNA | 0.714506 | 0.146 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.717509 | 0.144 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.717509 | 0.144 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.717509 | 0.144 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.717509 | 0.144 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.720480 | 0.142 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.720480 | 0.142 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.723421 | 0.141 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.723421 | 0.141 |
| R-HSA-202403 | TCR signaling | 0.723421 | 0.141 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.723421 | 0.141 |
| R-HSA-9679506 | SARS-CoV Infections | 0.725842 | 0.139 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.729209 | 0.137 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.729209 | 0.137 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.732058 | 0.135 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.742702 | 0.129 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.743159 | 0.129 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.745862 | 0.127 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.745862 | 0.127 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.753803 | 0.123 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.753803 | 0.123 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.758959 | 0.120 |
| R-HSA-157118 | Signaling by NOTCH | 0.759000 | 0.120 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.761497 | 0.118 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.761497 | 0.118 |
| R-HSA-194138 | Signaling by VEGF | 0.771385 | 0.113 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.771844 | 0.112 |
| R-HSA-114608 | Platelet degranulation | 0.776175 | 0.110 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.792168 | 0.101 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.798665 | 0.098 |
| R-HSA-913531 | Interferon Signaling | 0.798665 | 0.098 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.800791 | 0.096 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.800791 | 0.096 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.802891 | 0.095 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.804969 | 0.094 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.804969 | 0.094 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.815965 | 0.088 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.818915 | 0.087 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.824584 | 0.084 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.826435 | 0.083 |
| R-HSA-69242 | S Phase | 0.826435 | 0.083 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.827500 | 0.082 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.830077 | 0.081 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.833644 | 0.079 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.833644 | 0.079 |
| R-HSA-69306 | DNA Replication | 0.835399 | 0.078 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.837057 | 0.077 |
| R-HSA-1989781 | PPARA activates gene expression | 0.838855 | 0.076 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.842238 | 0.075 |
| R-HSA-388396 | GPCR downstream signalling | 0.844976 | 0.073 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.846136 | 0.073 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.853533 | 0.069 |
| R-HSA-9824446 | Viral Infection Pathways | 0.857649 | 0.067 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.864024 | 0.063 |
| R-HSA-1643685 | Disease | 0.865208 | 0.063 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.868288 | 0.061 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.871552 | 0.060 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.885282 | 0.053 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.887695 | 0.052 |
| R-HSA-8953854 | Metabolism of RNA | 0.889876 | 0.051 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.894169 | 0.049 |
| R-HSA-372790 | Signaling by GPCR | 0.903137 | 0.044 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.903233 | 0.044 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.904257 | 0.044 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.904257 | 0.044 |
| R-HSA-597592 | Post-translational protein modification | 0.906430 | 0.043 |
| R-HSA-449147 | Signaling by Interleukins | 0.910508 | 0.041 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.912443 | 0.040 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.913925 | 0.039 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.914837 | 0.039 |
| R-HSA-9748784 | Drug ADME | 0.919253 | 0.037 |
| R-HSA-168256 | Immune System | 0.920409 | 0.036 |
| R-HSA-8951664 | Neddylation | 0.921793 | 0.035 |
| R-HSA-72312 | rRNA processing | 0.930445 | 0.031 |
| R-HSA-8939211 | ESR-mediated signaling | 0.934056 | 0.030 |
| R-HSA-392499 | Metabolism of proteins | 0.938544 | 0.028 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.950037 | 0.022 |
| R-HSA-5663205 | Infectious disease | 0.953513 | 0.021 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.961412 | 0.017 |
| R-HSA-109582 | Hemostasis | 0.971701 | 0.012 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.973712 | 0.012 |
| R-HSA-8957322 | Metabolism of steroids | 0.973993 | 0.011 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.987875 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 0.989460 | 0.005 |
| R-HSA-168249 | Innate Immune System | 0.989755 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.991035 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.991482 | 0.004 |
| R-HSA-72766 | Translation | 0.991687 | 0.004 |
| R-HSA-112316 | Neuronal System | 0.994547 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.998536 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998561 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999712 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.858 | 0.643 | 1 | 0.904 |
CDK18 |
0.853 | 0.686 | 1 | 0.924 |
CDK19 |
0.850 | 0.675 | 1 | 0.906 |
HIPK2 |
0.848 | 0.639 | 1 | 0.907 |
CDK7 |
0.848 | 0.671 | 1 | 0.918 |
CDK17 |
0.847 | 0.683 | 1 | 0.921 |
CDK8 |
0.844 | 0.658 | 1 | 0.897 |
HIPK4 |
0.843 | 0.495 | 1 | 0.761 |
JNK2 |
0.843 | 0.702 | 1 | 0.928 |
ERK1 |
0.842 | 0.669 | 1 | 0.930 |
P38G |
0.841 | 0.684 | 1 | 0.922 |
P38B |
0.841 | 0.688 | 1 | 0.923 |
CDK1 |
0.840 | 0.646 | 1 | 0.923 |
DYRK2 |
0.840 | 0.618 | 1 | 0.878 |
CLK3 |
0.838 | 0.442 | 1 | 0.760 |
CDK13 |
0.838 | 0.643 | 1 | 0.926 |
CDK16 |
0.838 | 0.652 | 1 | 0.921 |
P38D |
0.837 | 0.681 | 1 | 0.921 |
CDK3 |
0.836 | 0.587 | 1 | 0.925 |
CDK14 |
0.836 | 0.650 | 1 | 0.914 |
CDK12 |
0.835 | 0.641 | 1 | 0.929 |
CDK5 |
0.835 | 0.620 | 1 | 0.907 |
P38A |
0.833 | 0.656 | 1 | 0.904 |
CDK9 |
0.833 | 0.627 | 1 | 0.923 |
JNK3 |
0.832 | 0.673 | 1 | 0.925 |
HIPK1 |
0.831 | 0.572 | 1 | 0.872 |
DYRK4 |
0.831 | 0.611 | 1 | 0.918 |
CDK10 |
0.830 | 0.597 | 1 | 0.922 |
NLK |
0.829 | 0.575 | 1 | 0.782 |
ERK2 |
0.825 | 0.632 | 1 | 0.919 |
ERK5 |
0.825 | 0.383 | 1 | 0.732 |
SRPK1 |
0.824 | 0.296 | -3 | 0.679 |
DYRK1B |
0.823 | 0.575 | 1 | 0.907 |
HIPK3 |
0.823 | 0.552 | 1 | 0.855 |
DYRK1A |
0.822 | 0.494 | 1 | 0.874 |
MAK |
0.816 | 0.481 | -2 | 0.836 |
CDK6 |
0.816 | 0.602 | 1 | 0.917 |
CDK4 |
0.815 | 0.616 | 1 | 0.926 |
ICK |
0.815 | 0.346 | -3 | 0.771 |
CDKL5 |
0.815 | 0.189 | -3 | 0.729 |
MTOR |
0.814 | 0.192 | 1 | 0.607 |
JNK1 |
0.813 | 0.599 | 1 | 0.923 |
CLK1 |
0.809 | 0.320 | -3 | 0.658 |
CLK2 |
0.809 | 0.330 | -3 | 0.664 |
DYRK3 |
0.809 | 0.429 | 1 | 0.839 |
CDK2 |
0.809 | 0.449 | 1 | 0.859 |
COT |
0.808 | 0.003 | 2 | 0.814 |
SRPK2 |
0.808 | 0.216 | -3 | 0.598 |
CLK4 |
0.807 | 0.296 | -3 | 0.673 |
CDKL1 |
0.807 | 0.138 | -3 | 0.725 |
MOS |
0.805 | 0.081 | 1 | 0.530 |
CDC7 |
0.805 | -0.019 | 1 | 0.478 |
NDR2 |
0.803 | 0.051 | -3 | 0.796 |
PRKD1 |
0.801 | 0.085 | -3 | 0.790 |
MOK |
0.799 | 0.410 | 1 | 0.807 |
PRP4 |
0.799 | 0.384 | -3 | 0.718 |
PIM3 |
0.798 | 0.014 | -3 | 0.768 |
CHAK2 |
0.798 | 0.044 | -1 | 0.814 |
PRPK |
0.797 | -0.085 | -1 | 0.813 |
PRKD2 |
0.796 | 0.063 | -3 | 0.720 |
AURC |
0.796 | 0.071 | -2 | 0.670 |
SRPK3 |
0.796 | 0.182 | -3 | 0.634 |
TBK1 |
0.795 | -0.087 | 1 | 0.420 |
WNK1 |
0.794 | -0.046 | -2 | 0.885 |
ATR |
0.793 | -0.018 | 1 | 0.496 |
SKMLCK |
0.793 | 0.017 | -2 | 0.855 |
RAF1 |
0.792 | -0.141 | 1 | 0.477 |
CAMK1B |
0.792 | -0.033 | -3 | 0.767 |
RSK2 |
0.792 | 0.019 | -3 | 0.709 |
NDR1 |
0.791 | -0.016 | -3 | 0.764 |
PDHK4 |
0.791 | -0.155 | 1 | 0.534 |
MST4 |
0.790 | -0.035 | 2 | 0.826 |
PKN3 |
0.790 | -0.020 | -3 | 0.748 |
NUAK2 |
0.790 | -0.017 | -3 | 0.754 |
IKKB |
0.790 | -0.112 | -2 | 0.735 |
NEK6 |
0.790 | -0.017 | -2 | 0.791 |
GCN2 |
0.789 | -0.164 | 2 | 0.755 |
RIPK3 |
0.789 | -0.086 | 3 | 0.751 |
IKKE |
0.789 | -0.112 | 1 | 0.414 |
PKN2 |
0.788 | -0.043 | -3 | 0.746 |
P90RSK |
0.788 | 0.009 | -3 | 0.707 |
NIK |
0.788 | -0.028 | -3 | 0.786 |
CAMLCK |
0.788 | 0.006 | -2 | 0.842 |
BMPR2 |
0.787 | -0.134 | -2 | 0.847 |
ERK7 |
0.787 | 0.218 | 2 | 0.526 |
TGFBR2 |
0.786 | -0.033 | -2 | 0.749 |
MPSK1 |
0.786 | 0.171 | 1 | 0.518 |
PKCD |
0.786 | 0.011 | 2 | 0.744 |
AMPKA1 |
0.785 | -0.052 | -3 | 0.780 |
MAPKAPK3 |
0.785 | -0.007 | -3 | 0.716 |
MLK2 |
0.785 | 0.012 | 2 | 0.782 |
ULK2 |
0.785 | -0.174 | 2 | 0.748 |
PDHK1 |
0.785 | -0.152 | 1 | 0.502 |
PKACG |
0.784 | -0.006 | -2 | 0.757 |
PIM1 |
0.784 | 0.015 | -3 | 0.700 |
IRE1 |
0.784 | -0.067 | 1 | 0.465 |
DAPK2 |
0.784 | -0.021 | -3 | 0.784 |
GSK3A |
0.784 | 0.157 | 4 | 0.378 |
RSK3 |
0.784 | -0.016 | -3 | 0.691 |
LATS2 |
0.783 | -0.014 | -5 | 0.764 |
MARK4 |
0.782 | -0.081 | 4 | 0.660 |
GRK5 |
0.782 | -0.110 | -3 | 0.757 |
GRK1 |
0.782 | -0.003 | -2 | 0.788 |
TSSK1 |
0.782 | -0.027 | -3 | 0.811 |
AMPKA2 |
0.781 | -0.038 | -3 | 0.751 |
MNK2 |
0.781 | 0.003 | -2 | 0.785 |
MLK3 |
0.781 | 0.001 | 2 | 0.707 |
MASTL |
0.781 | -0.119 | -2 | 0.792 |
PKCA |
0.780 | 0.024 | 2 | 0.699 |
DSTYK |
0.780 | -0.153 | 2 | 0.814 |
MAPKAPK2 |
0.780 | 0.004 | -3 | 0.672 |
CAMK2G |
0.780 | -0.146 | 2 | 0.716 |
PHKG1 |
0.780 | -0.029 | -3 | 0.748 |
MNK1 |
0.780 | 0.014 | -2 | 0.793 |
NEK7 |
0.779 | -0.160 | -3 | 0.765 |
PRKD3 |
0.779 | 0.012 | -3 | 0.667 |
CAMK2D |
0.779 | -0.057 | -3 | 0.771 |
MLK1 |
0.779 | -0.142 | 2 | 0.773 |
IKKA |
0.779 | -0.056 | -2 | 0.719 |
LATS1 |
0.779 | 0.049 | -3 | 0.817 |
HUNK |
0.778 | -0.181 | 2 | 0.779 |
P70S6KB |
0.778 | -0.030 | -3 | 0.709 |
PAK6 |
0.778 | 0.023 | -2 | 0.716 |
PKG2 |
0.778 | 0.030 | -2 | 0.696 |
TSSK2 |
0.778 | -0.064 | -5 | 0.857 |
PKCG |
0.777 | -0.015 | 2 | 0.710 |
IRE2 |
0.777 | -0.048 | 2 | 0.715 |
NIM1 |
0.777 | -0.097 | 3 | 0.762 |
WNK3 |
0.777 | -0.224 | 1 | 0.468 |
PKACB |
0.777 | 0.038 | -2 | 0.679 |
PKCB |
0.776 | -0.018 | 2 | 0.709 |
PAK3 |
0.776 | -0.044 | -2 | 0.792 |
RIPK1 |
0.776 | -0.162 | 1 | 0.462 |
PKCZ |
0.776 | -0.025 | 2 | 0.753 |
ALK4 |
0.776 | 0.005 | -2 | 0.824 |
PAK1 |
0.776 | -0.033 | -2 | 0.800 |
AURB |
0.775 | 0.008 | -2 | 0.665 |
GRK7 |
0.775 | 0.022 | 1 | 0.471 |
BUB1 |
0.775 | 0.183 | -5 | 0.807 |
AKT2 |
0.775 | 0.032 | -3 | 0.610 |
ULK1 |
0.774 | -0.174 | -3 | 0.722 |
MELK |
0.774 | -0.062 | -3 | 0.734 |
BMPR1B |
0.774 | 0.003 | 1 | 0.442 |
VRK2 |
0.774 | 0.044 | 1 | 0.558 |
RSK4 |
0.774 | 0.013 | -3 | 0.690 |
CAMK4 |
0.773 | -0.092 | -3 | 0.730 |
BCKDK |
0.773 | -0.162 | -1 | 0.712 |
NUAK1 |
0.773 | -0.061 | -3 | 0.704 |
TGFBR1 |
0.773 | 0.001 | -2 | 0.793 |
QSK |
0.773 | -0.051 | 4 | 0.654 |
SGK3 |
0.772 | 0.003 | -3 | 0.693 |
NEK9 |
0.772 | -0.171 | 2 | 0.802 |
SMG1 |
0.772 | -0.050 | 1 | 0.462 |
GSK3B |
0.772 | 0.033 | 4 | 0.374 |
ANKRD3 |
0.772 | -0.141 | 1 | 0.490 |
DLK |
0.771 | -0.184 | 1 | 0.470 |
PINK1 |
0.771 | 0.087 | 1 | 0.649 |
NEK2 |
0.770 | -0.093 | 2 | 0.796 |
QIK |
0.770 | -0.127 | -3 | 0.753 |
CAMK2A |
0.770 | -0.031 | 2 | 0.704 |
PKR |
0.769 | -0.101 | 1 | 0.495 |
CHAK1 |
0.769 | -0.128 | 2 | 0.779 |
PIM2 |
0.769 | 0.012 | -3 | 0.668 |
PRKX |
0.769 | 0.031 | -3 | 0.618 |
DNAPK |
0.768 | -0.051 | 1 | 0.435 |
PKCH |
0.768 | -0.065 | 2 | 0.693 |
PAK2 |
0.767 | -0.057 | -2 | 0.784 |
MSK1 |
0.767 | -0.022 | -3 | 0.671 |
DCAMKL1 |
0.767 | -0.033 | -3 | 0.709 |
YSK4 |
0.767 | -0.111 | 1 | 0.434 |
MYLK4 |
0.767 | -0.040 | -2 | 0.770 |
MSK2 |
0.766 | -0.062 | -3 | 0.669 |
CHK1 |
0.766 | -0.012 | -3 | 0.770 |
GRK6 |
0.766 | -0.170 | 1 | 0.465 |
MST3 |
0.766 | -0.033 | 2 | 0.825 |
MEK1 |
0.766 | -0.147 | 2 | 0.803 |
TLK2 |
0.765 | -0.041 | 1 | 0.442 |
TTBK2 |
0.764 | -0.189 | 2 | 0.680 |
SIK |
0.764 | -0.079 | -3 | 0.671 |
ATM |
0.764 | -0.116 | 1 | 0.437 |
CAMK2B |
0.763 | -0.079 | 2 | 0.662 |
PASK |
0.762 | 0.019 | -3 | 0.795 |
MARK3 |
0.762 | -0.081 | 4 | 0.609 |
BRSK2 |
0.762 | -0.116 | -3 | 0.736 |
GRK4 |
0.762 | -0.170 | -2 | 0.796 |
LKB1 |
0.761 | 0.069 | -3 | 0.774 |
WNK4 |
0.761 | -0.123 | -2 | 0.875 |
AKT1 |
0.761 | 0.008 | -3 | 0.635 |
PKCI |
0.761 | -0.033 | 2 | 0.727 |
PLK4 |
0.761 | -0.082 | 2 | 0.603 |
PKACA |
0.760 | 0.011 | -2 | 0.636 |
CAMK1G |
0.760 | -0.085 | -3 | 0.666 |
ACVR2B |
0.760 | -0.071 | -2 | 0.751 |
SNRK |
0.760 | -0.164 | 2 | 0.653 |
MLK4 |
0.760 | -0.103 | 2 | 0.678 |
SSTK |
0.759 | -0.056 | 4 | 0.632 |
IRAK4 |
0.759 | -0.117 | 1 | 0.448 |
CK1E |
0.759 | -0.042 | -3 | 0.444 |
MEK5 |
0.759 | -0.149 | 2 | 0.790 |
AURA |
0.759 | -0.029 | -2 | 0.627 |
ACVR2A |
0.759 | -0.073 | -2 | 0.740 |
NEK5 |
0.759 | -0.077 | 1 | 0.476 |
PKCT |
0.758 | -0.057 | 2 | 0.698 |
ALK2 |
0.758 | -0.063 | -2 | 0.793 |
MARK2 |
0.758 | -0.107 | 4 | 0.587 |
DCAMKL2 |
0.758 | -0.056 | -3 | 0.725 |
PLK1 |
0.758 | -0.165 | -2 | 0.722 |
BRSK1 |
0.758 | -0.112 | -3 | 0.708 |
DRAK1 |
0.758 | -0.130 | 1 | 0.436 |
AKT3 |
0.757 | 0.049 | -3 | 0.564 |
PKCE |
0.757 | -0.011 | 2 | 0.701 |
PERK |
0.757 | -0.126 | -2 | 0.784 |
PAK5 |
0.756 | -0.020 | -2 | 0.650 |
TAO3 |
0.756 | -0.048 | 1 | 0.480 |
MAPKAPK5 |
0.755 | -0.106 | -3 | 0.634 |
GRK2 |
0.755 | -0.095 | -2 | 0.716 |
ZAK |
0.755 | -0.144 | 1 | 0.425 |
MEKK2 |
0.755 | -0.120 | 2 | 0.765 |
HRI |
0.754 | -0.179 | -2 | 0.800 |
PBK |
0.754 | 0.040 | 1 | 0.485 |
PKN1 |
0.754 | -0.029 | -3 | 0.644 |
PHKG2 |
0.754 | -0.114 | -3 | 0.703 |
P70S6K |
0.753 | -0.053 | -3 | 0.625 |
PDK1 |
0.753 | -0.035 | 1 | 0.500 |
NEK11 |
0.753 | -0.113 | 1 | 0.480 |
MEKK1 |
0.753 | -0.170 | 1 | 0.456 |
CK1D |
0.753 | -0.014 | -3 | 0.396 |
PAK4 |
0.753 | -0.007 | -2 | 0.652 |
SMMLCK |
0.753 | -0.059 | -3 | 0.729 |
GCK |
0.752 | -0.022 | 1 | 0.483 |
GAK |
0.752 | -0.042 | 1 | 0.528 |
TLK1 |
0.752 | -0.114 | -2 | 0.776 |
MEKK6 |
0.752 | -0.076 | 1 | 0.464 |
BMPR1A |
0.752 | -0.042 | 1 | 0.413 |
MEKK3 |
0.751 | -0.200 | 1 | 0.461 |
SBK |
0.750 | 0.084 | -3 | 0.504 |
MARK1 |
0.750 | -0.136 | 4 | 0.618 |
HPK1 |
0.750 | -0.038 | 1 | 0.478 |
NEK4 |
0.750 | -0.089 | 1 | 0.450 |
FAM20C |
0.750 | -0.103 | 2 | 0.462 |
TNIK |
0.750 | -0.004 | 3 | 0.863 |
CAMKK2 |
0.750 | -0.043 | -2 | 0.716 |
MAP3K15 |
0.750 | -0.050 | 1 | 0.436 |
BRAF |
0.749 | -0.139 | -4 | 0.855 |
HGK |
0.749 | -0.036 | 3 | 0.861 |
KHS1 |
0.748 | 0.000 | 1 | 0.465 |
TAO2 |
0.748 | -0.092 | 2 | 0.803 |
SGK1 |
0.747 | 0.014 | -3 | 0.542 |
LOK |
0.747 | -0.021 | -2 | 0.747 |
NEK8 |
0.747 | -0.142 | 2 | 0.788 |
CAMK1D |
0.746 | -0.057 | -3 | 0.611 |
KHS2 |
0.746 | 0.008 | 1 | 0.483 |
CK1G1 |
0.746 | -0.082 | -3 | 0.418 |
CK1A2 |
0.746 | -0.049 | -3 | 0.392 |
MRCKB |
0.745 | -0.004 | -3 | 0.652 |
CHK2 |
0.745 | -0.033 | -3 | 0.556 |
NEK1 |
0.745 | -0.071 | 1 | 0.451 |
LRRK2 |
0.745 | -0.062 | 2 | 0.812 |
PLK3 |
0.745 | -0.182 | 2 | 0.700 |
ROCK2 |
0.745 | 0.006 | -3 | 0.713 |
MINK |
0.744 | -0.096 | 1 | 0.455 |
HASPIN |
0.744 | 0.018 | -1 | 0.674 |
MRCKA |
0.744 | -0.016 | -3 | 0.668 |
EEF2K |
0.743 | -0.074 | 3 | 0.798 |
SLK |
0.743 | -0.029 | -2 | 0.697 |
CAMKK1 |
0.743 | -0.162 | -2 | 0.710 |
MST2 |
0.742 | -0.112 | 1 | 0.459 |
TTBK1 |
0.741 | -0.171 | 2 | 0.607 |
PDHK3_TYR |
0.740 | 0.215 | 4 | 0.693 |
DAPK3 |
0.740 | -0.064 | -3 | 0.711 |
TAK1 |
0.739 | -0.132 | 1 | 0.465 |
CAMK1A |
0.739 | -0.037 | -3 | 0.573 |
LIMK2_TYR |
0.738 | 0.215 | -3 | 0.832 |
YSK1 |
0.737 | -0.089 | 2 | 0.785 |
MST1 |
0.737 | -0.104 | 1 | 0.447 |
GRK3 |
0.737 | -0.102 | -2 | 0.676 |
DAPK1 |
0.736 | -0.063 | -3 | 0.691 |
VRK1 |
0.735 | -0.179 | 2 | 0.799 |
IRAK1 |
0.735 | -0.261 | -1 | 0.692 |
DMPK1 |
0.735 | 0.011 | -3 | 0.670 |
CRIK |
0.735 | 0.012 | -3 | 0.650 |
PKG1 |
0.735 | -0.027 | -2 | 0.618 |
STK33 |
0.734 | -0.130 | 2 | 0.595 |
TESK1_TYR |
0.734 | 0.134 | 3 | 0.868 |
CK2A2 |
0.733 | -0.090 | 1 | 0.395 |
PKMYT1_TYR |
0.732 | 0.112 | 3 | 0.846 |
NEK3 |
0.731 | -0.096 | 1 | 0.441 |
MEK2 |
0.731 | -0.183 | 2 | 0.779 |
PDHK4_TYR |
0.730 | 0.100 | 2 | 0.823 |
BIKE |
0.729 | -0.010 | 1 | 0.471 |
MAP2K4_TYR |
0.729 | 0.080 | -1 | 0.827 |
RIPK2 |
0.729 | -0.231 | 1 | 0.400 |
MYO3B |
0.728 | -0.046 | 2 | 0.805 |
ROCK1 |
0.728 | -0.033 | -3 | 0.665 |
CK2A1 |
0.726 | -0.092 | 1 | 0.381 |
AAK1 |
0.726 | 0.039 | 1 | 0.438 |
OSR1 |
0.724 | -0.062 | 2 | 0.779 |
MAP2K6_TYR |
0.724 | 0.012 | -1 | 0.834 |
MAP2K7_TYR |
0.723 | -0.071 | 2 | 0.805 |
ASK1 |
0.722 | -0.104 | 1 | 0.426 |
MYO3A |
0.722 | -0.085 | 1 | 0.462 |
PDHK1_TYR |
0.721 | -0.025 | -1 | 0.842 |
TAO1 |
0.721 | -0.099 | 1 | 0.423 |
BMPR2_TYR |
0.720 | -0.019 | -1 | 0.818 |
LIMK1_TYR |
0.719 | -0.031 | 2 | 0.804 |
PLK2 |
0.718 | -0.133 | -3 | 0.650 |
PINK1_TYR |
0.716 | -0.179 | 1 | 0.523 |
JAK2 |
0.715 | -0.054 | 1 | 0.469 |
TTK |
0.714 | -0.137 | -2 | 0.748 |
RET |
0.714 | -0.089 | 1 | 0.469 |
MST1R |
0.713 | -0.076 | 3 | 0.810 |
ROS1 |
0.713 | -0.092 | 3 | 0.773 |
CK1A |
0.713 | -0.061 | -3 | 0.304 |
TNNI3K_TYR |
0.713 | 0.007 | 1 | 0.477 |
ABL2 |
0.712 | -0.032 | -1 | 0.748 |
YANK3 |
0.712 | -0.083 | 2 | 0.381 |
TNK1 |
0.712 | -0.006 | 3 | 0.795 |
CSF1R |
0.711 | -0.068 | 3 | 0.802 |
TNK2 |
0.711 | -0.019 | 3 | 0.740 |
TYRO3 |
0.711 | -0.100 | 3 | 0.800 |
EPHA6 |
0.710 | -0.072 | -1 | 0.784 |
FGR |
0.710 | -0.089 | 1 | 0.483 |
ABL1 |
0.710 | -0.048 | -1 | 0.741 |
NEK10_TYR |
0.709 | -0.061 | 1 | 0.425 |
JAK1 |
0.709 | -0.041 | 1 | 0.423 |
EPHB4 |
0.709 | -0.066 | -1 | 0.749 |
TYK2 |
0.708 | -0.201 | 1 | 0.458 |
TXK |
0.708 | -0.010 | 1 | 0.444 |
LCK |
0.707 | -0.045 | -1 | 0.784 |
YES1 |
0.706 | -0.104 | -1 | 0.803 |
JAK3 |
0.705 | -0.118 | 1 | 0.454 |
DDR1 |
0.705 | -0.174 | 4 | 0.609 |
ALPHAK3 |
0.703 | -0.137 | -1 | 0.716 |
HCK |
0.703 | -0.114 | -1 | 0.779 |
BLK |
0.703 | -0.062 | -1 | 0.791 |
KDR |
0.701 | -0.069 | 3 | 0.760 |
TEK |
0.701 | -0.026 | 3 | 0.729 |
ITK |
0.701 | -0.093 | -1 | 0.733 |
STLK3 |
0.700 | -0.184 | 1 | 0.400 |
EPHA4 |
0.699 | -0.077 | 2 | 0.703 |
FGFR2 |
0.699 | -0.091 | 3 | 0.775 |
FGFR1 |
0.697 | -0.070 | 3 | 0.747 |
KIT |
0.697 | -0.130 | 3 | 0.794 |
INSRR |
0.696 | -0.173 | 3 | 0.739 |
FER |
0.696 | -0.200 | 1 | 0.479 |
MET |
0.696 | -0.089 | 3 | 0.789 |
SRMS |
0.696 | -0.142 | 1 | 0.448 |
EPHB1 |
0.695 | -0.131 | 1 | 0.444 |
EPHB3 |
0.694 | -0.106 | -1 | 0.728 |
AXL |
0.694 | -0.127 | 3 | 0.771 |
WEE1_TYR |
0.693 | -0.112 | -1 | 0.671 |
MERTK |
0.693 | -0.114 | 3 | 0.779 |
BMX |
0.692 | -0.097 | -1 | 0.657 |
PDGFRB |
0.692 | -0.215 | 3 | 0.796 |
FYN |
0.692 | -0.079 | -1 | 0.766 |
DDR2 |
0.691 | -0.084 | 3 | 0.711 |
PDGFRA |
0.691 | -0.186 | 3 | 0.795 |
EPHB2 |
0.691 | -0.134 | -1 | 0.725 |
FLT3 |
0.690 | -0.222 | 3 | 0.797 |
FRK |
0.689 | -0.131 | -1 | 0.783 |
TEC |
0.689 | -0.141 | -1 | 0.662 |
FLT1 |
0.687 | -0.118 | -1 | 0.759 |
PTK2B |
0.687 | -0.074 | -1 | 0.705 |
LYN |
0.687 | -0.113 | 3 | 0.725 |
ALK |
0.687 | -0.175 | 3 | 0.703 |
FGFR3 |
0.686 | -0.110 | 3 | 0.748 |
EPHA7 |
0.685 | -0.111 | 2 | 0.707 |
BTK |
0.685 | -0.227 | -1 | 0.698 |
EPHA1 |
0.685 | -0.138 | 3 | 0.769 |
PTK6 |
0.683 | -0.189 | -1 | 0.652 |
ERBB2 |
0.683 | -0.171 | 1 | 0.423 |
LTK |
0.683 | -0.185 | 3 | 0.728 |
EPHA3 |
0.682 | -0.140 | 2 | 0.674 |
SRC |
0.682 | -0.122 | -1 | 0.758 |
FLT4 |
0.682 | -0.169 | 3 | 0.750 |
MATK |
0.681 | -0.116 | -1 | 0.672 |
NTRK3 |
0.681 | -0.130 | -1 | 0.688 |
INSR |
0.681 | -0.200 | 3 | 0.729 |
NTRK1 |
0.680 | -0.225 | -1 | 0.735 |
YANK2 |
0.678 | -0.102 | 2 | 0.383 |
CK1G3 |
0.678 | -0.090 | -3 | 0.255 |
NTRK2 |
0.678 | -0.231 | 3 | 0.743 |
PTK2 |
0.677 | -0.060 | -1 | 0.729 |
EPHA8 |
0.675 | -0.119 | -1 | 0.717 |
MUSK |
0.675 | -0.139 | 1 | 0.360 |
CSK |
0.673 | -0.161 | 2 | 0.714 |
EGFR |
0.672 | -0.135 | 1 | 0.358 |
EPHA5 |
0.672 | -0.155 | 2 | 0.674 |
SYK |
0.672 | -0.083 | -1 | 0.714 |
FGFR4 |
0.671 | -0.125 | -1 | 0.691 |
EPHA2 |
0.667 | -0.110 | -1 | 0.682 |
ERBB4 |
0.667 | -0.097 | 1 | 0.369 |
CK1G2 |
0.665 | -0.085 | -3 | 0.340 |
ZAP70 |
0.665 | -0.028 | -1 | 0.642 |
IGF1R |
0.663 | -0.187 | 3 | 0.667 |
FES |
0.651 | -0.179 | -1 | 0.623 |