Motif 945 (n=208)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PNV4 | None | S643 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| A6NFI3 | ZNF316 | S105 | ochoa | Zinc finger protein 316 | May be involved in transcriptional regulation. {ECO:0000250}. |
| A6NKT7 | RGPD3 | S1622 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00541 | PES1 | S530 | ochoa | Pescadillo homolog | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}. |
| O14715 | RGPD8 | S1621 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15143 | ARPC1B | S311 | ochoa | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O15231 | ZNF185 | S203 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O43156 | TTI1 | S106 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43166 | SIPA1L1 | S288 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43772 | SLC25A20 | S143 | ochoa | Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (CACT) (Solute carrier family 25 member 20) | Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable) (PubMed:12892634, PubMed:18307102). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102). {ECO:0000269|PubMed:12892634, ECO:0000269|PubMed:18307102, ECO:0000305|PubMed:18307102, ECO:0000305|PubMed:20347717}. |
| O43847 | NRDC | S96 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60242 | ADGRB3 | S1236 | ochoa | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) | Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:Q80ZF8, ECO:0000269|PubMed:24567399}. |
| O60437 | PPL | S422 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60437 | PPL | S915 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60749 | SNX2 | S277 | ochoa | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| O75030 | MITF | S405 | psp | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}. |
| O75164 | KDM4A | S1019 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75643 | SNRNP200 | S2002 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75691 | UTP20 | S1734 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O75792 | RNASEH2A | S208 | psp | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| O94818 | NOL4 | S312 | ochoa | Nucleolar protein 4 (Nucleolar-localized protein) | None |
| O94856 | NFASC | S1284 | ochoa | Neurofascin | Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}. |
| O95398 | RAPGEF3 | S267 | ochoa | Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}. |
| O95613 | PCNT | S455 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95714 | HERC2 | S368 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| P04083 | ANXA1 | S170 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P06732 | CKM | S94 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P08670 | VIM | S299 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08708 | RPS17 | S115 | ochoa | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P09651 | HNRNPA1 | S22 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P11137 | MAP2 | S1480 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P12270 | TPR | S1187 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P14625 | HSP90B1 | S64 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P14625 | HSP90B1 | S169 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P16284 | PECAM1 | S661 | ochoa | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P17661 | DES | S424 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P18583 | SON | S2238 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19237 | TNNI1 | S58 | ochoa | Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P20929 | NEB | S1380 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P22466 | GAL | S76 | ochoa | Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)] | Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. {ECO:0000269|PubMed:1370155, ECO:0000269|PubMed:1722333, ECO:0000269|PubMed:25691535}. |
| P22626 | HNRNPA2B1 | S29 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23327 | HRC | S440 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P26639 | TARS1 | S70 | ochoa | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P29350 | PTPN6 | S140 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P29375 | KDM5A | S1255 | psp | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P33241 | LSP1 | S141 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P35222 | CTNNB1 | S675 | ochoa|psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35228 | NOS2 | S80 | ochoa | Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2) | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109). {ECO:0000250|UniProtKB:P29477, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:7504305, ECO:0000269|PubMed:7531687, ECO:0000269|PubMed:7544004, ECO:0000269|PubMed:7682706}. |
| P35579 | MYH9 | S1326 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1628 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P36897 | TGFBR1 | S172 | psp | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P39687 | ANP32A | S96 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| P46013 | MKI67 | S1970 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2575 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S596 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P48552 | NRIP1 | S102 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P50851 | LRBA | S1576 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51957 | NEK4 | S661 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P51991 | HNRNPA3 | S43 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P55072 | VCP | S284 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P61764 | STXBP1 | S313 | psp | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P61769 | B2M | S75 | ochoa | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}. |
| Q00839 | HNRNPU | S26 | psp | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q02447 | SP3 | S563 | ochoa|psp | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q05209 | PTPN12 | S491 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05682 | CALD1 | S628 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q05D32 | CTDSPL2 | S50 | ochoa | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q07157 | TJP1 | S275 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08357 | SLC20A2 | S422 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q0ZGT2 | NEXN | S243 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12789 | GTF3C1 | S602 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12873 | CHD3 | S1819 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12888 | TP53BP1 | S507 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S860 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12906 | ILF3 | S190 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12923 | PTPN13 | S941 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12968 | NFATC3 | S344 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13017 | ARHGAP5 | S951 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13136 | PPFIA1 | S448 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13435 | SF3B2 | S450 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13507 | TRPC3 | S336 | psp | Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:29726814, PubMed:30139744, PubMed:35051376, PubMed:9417057, PubMed:9930701, PubMed:10611319). {ECO:0000269|PubMed:10611319, ECO:0000269|PubMed:29726814, ECO:0000269|PubMed:30139744, ECO:0000269|PubMed:35051376, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.; FUNCTION: [Isoform 2]: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. {ECO:0000269|PubMed:8646775}. |
| Q13596 | SNX1 | S280 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q14157 | UBAP2L | S254 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q15042 | RAB3GAP1 | S664 | ochoa | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:10859313, PubMed:24891604, PubMed:9030515). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129). {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:15696165, ECO:0000269|PubMed:23420520, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9030515, ECO:0000269|PubMed:9852129}. |
| Q15121 | PEA15 | S61 | ochoa | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}. |
| Q15149 | PLEC | S3143 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S3276 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15746 | MYLK | S1122 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16543 | CDC37 | S120 | ochoa | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q17RY0 | CPEB4 | S97 | ochoa | Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4) | Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}. |
| Q2LD37 | BLTP1 | S4538 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q32P51 | HNRNPA1L2 | S22 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q5JRA6 | MIA3 | S1553 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5MIZ7 | PPP4R3B | S154 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. |
| Q5SW79 | CEP170 | S485 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5TAP6 | UTP14C | S28 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog C | Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}. |
| Q5TH69 | ARFGEF3 | S471 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VT06 | CEP350 | S2860 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VV67 | PPRC1 | S171 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q5VZL5 | ZMYM4 | S1144 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q5W0B1 | OBI1 | S276 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6IN85 | PPP4R3A | S737 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IQ23 | PLEKHA7 | S1020 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NUM9 | RETSAT | S484 | ochoa | All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein) | Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. {ECO:0000250|UniProtKB:Q64FW2}. |
| Q6NV74 | CRACDL | S92 | ochoa | CRACD-like protein | None |
| Q6NXT6 | TAPT1 | S523 | ochoa | Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) | Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7, ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}.; FUNCTION: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. {ECO:0000269|PubMed:10640539}. |
| Q6P1M3 | LLGL2 | S1000 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6PCB5 | RSBN1L | S823 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6U841 | SLC4A10 | S89 | ochoa | Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) | Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q5DTL9, ECO:0000250|UniProtKB:Q80ZA5, ECO:0000269|PubMed:18319254}. |
| Q6VMQ6 | ATF7IP | S445 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q71F23 | CENPU | S96 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q71F23 | CENPU | S190 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7L775 | EPM2AIP1 | S146 | ochoa | EPM2A-interacting protein 1 (Laforin-interacting protein) | None |
| Q7Z2E3 | APTX | S158 | ochoa | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15044383, PubMed:15380105, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:16547001, ECO:0000269|PubMed:16964241, ECO:0000269|PubMed:17276982, ECO:0000269|PubMed:24362567}. |
| Q7Z2Z1 | TICRR | S1771 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z4H7 | HAUS6 | S742 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q86U70 | LDB1 | S265 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q86UE4 | MTDH | S496 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UP3 | ZFHX4 | S3542 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86XA9 | HEATR5A | S58 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86YC2 | PALB2 | S64 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IUH4 | ZDHHC13 | S208 | psp | Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin-interacting protein HIP3RP) (Putative MAPK-activating protein PM03) (Putative NF-kappa-B-activating protein 209) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport. {ECO:0000250|UniProtKB:Q9CWU2}. |
| Q8IVF2 | AHNAK2 | S5128 | ochoa | Protein AHNAK2 | None |
| Q8N556 | AFAP1 | S282 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8NB91 | FANCB | S465 | ochoa | Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) | DNA repair protein required for FANCD2 ubiquitination. {ECO:0000269|PubMed:15502827}. |
| Q8NCF5 | NFATC2IP | S390 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NFM4 | ADCY4 | S253 | ochoa | Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. {ECO:0000250|UniProtKB:P26770}. |
| Q8NFW8 | CMAS | S387 | ochoa | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). |
| Q8NHS3 | MFSD8 | S20 | ochoa | Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7) | Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions. {ECO:0000269|PubMed:34910516}. |
| Q8NHZ8 | CDC26 | S56 | ochoa | Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). May recruit the E2 ubiquitin-conjugating enzymes to the complex (PubMed:18485873). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q8TE99 | PXYLP1 | S392 | ochoa | 2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124) | Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}. |
| Q8WUA4 | GTF3C2 | S85 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUX9 | CHMP7 | S431 | ochoa | Charged multivesicular body protein 7 (Chromatin-modifying protein 7) | ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| Q8WXE1 | ATRIP | S72 | psp | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WXH0 | SYNE2 | S5860 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92576 | PHF3 | S342 | ochoa | PHD finger protein 3 | None |
| Q92688 | ANP32B | S96 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| Q92692 | NECTIN2 | S430 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92797 | SYMPK | S1081 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92985 | IRF7 | S479 | psp | Interferon regulatory factor 7 (IRF-7) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865, PubMed:28768858). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). {ECO:0000250|UniProtKB:P70434, ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045, ECO:0000269|PubMed:17574024, ECO:0000269|PubMed:28342865, ECO:0000269|PubMed:28768858, ECO:0000269|PubMed:32972995}. |
| Q96DF8 | ESS2 | S391 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96ED9 | HOOK2 | S163 | ochoa | Protein Hook homolog 2 (h-hook2) (hHK2) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q96ED9 | HOOK2 | S316 | ochoa | Protein Hook homolog 2 (h-hook2) (hHK2) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q96FF7 | MISP3 | S174 | ochoa | Uncharacterized protein MISP3 (MISP family member 3) | None |
| Q96IT1 | ZNF496 | S391 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q99569 | PKP4 | Y1115 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99666 | RGPD5 | S1621 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BSQ5 | CCM2 | S183 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BST9 | RTKN | S30 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9BXP5 | SRRT | S718 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BY42 | RTF2 | S287 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q9BYW2 | SETD2 | S717 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZI7 | UPF3B | S310 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9C0D5 | TANC1 | S609 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H257 | CARD9 | S450 | ochoa | Caspase recruitment domain-containing protein 9 (hCARD9) | Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25057046, PubMed:25702837, PubMed:26521038, PubMed:26679537, PubMed:26961233, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:26961233, PubMed:31296852, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:A2AIV8, ECO:0000269|PubMed:11053425, ECO:0000269|PubMed:24231284, ECO:0000269|PubMed:25057046, ECO:0000269|PubMed:25702837, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:26521038, ECO:0000269|PubMed:26679537, ECO:0000269|PubMed:26961233, ECO:0000269|PubMed:27777981, ECO:0000269|PubMed:29080677, ECO:0000269|PubMed:31296852, ECO:0000269|PubMed:33548172, ECO:0000269|PubMed:33558980}. |
| Q9H3Q1 | CDC42EP4 | S109 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4B6 | SAV1 | S36 | psp | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}. |
| Q9H4G0 | EPB41L1 | S75 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H799 | CPLANE1 | S156 | ochoa | Ciliogenesis and planar polarity effector 1 (Protein JBTS17) | Involved in ciliogenesis (PubMed:25877302, PubMed:35582950). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000269|PubMed:35582950, ECO:0000305|PubMed:25877302}. |
| Q9H7E2 | TDRD3 | S80 | ochoa | Tudor domain-containing protein 3 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}. |
| Q9HCN4 | GPN1 | S301 | ochoa | GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) | Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000305|PubMed:11058119}. |
| Q9NP80 | PNPLA8 | S515 | psp | Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) | Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428, PubMed:17213206, PubMed:18171998, PubMed:28442572). Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former (PubMed:15695510). Also has a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428). However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates (PubMed:15908428). Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers (PubMed:15695510, PubMed:15908428). Can also hydrolyze lysophosphatidylcholine (PubMed:15695510). In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:28442572). {ECO:0000250|UniProtKB:Q8K1N1, ECO:0000269|PubMed:10744668, ECO:0000269|PubMed:10833412, ECO:0000269|PubMed:15695510, ECO:0000269|PubMed:15908428, ECO:0000269|PubMed:17213206, ECO:0000269|PubMed:18171998, ECO:0000269|PubMed:28442572}. |
| Q9NPD8 | UBE2T | S172 | ochoa | Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:28437106}. |
| Q9NQA5 | TRPV5 | S299 | psp | Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:11549322, ECO:0000269|PubMed:18768590}. |
| Q9NQP4 | PFDN4 | S107 | ochoa | Prefoldin subunit 4 (Protein C-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q9NRA8 | EIF4ENIF1 | S374 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NVF7 | FBXO28 | S330 | ochoa | F-box only protein 28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}. |
| Q9P0J7 | KCMF1 | S212 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9UBC2 | EPS15L1 | S49 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBT7 | CTNNAL1 | S538 | ochoa | Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) | May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). |
| Q9UHB6 | LIMA1 | S178 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB6 | LIMA1 | S263 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | S598 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UIJ5 | ZDHHC2 | S341 | ochoa | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}. |
| Q9UJS0 | SLC25A13 | S472 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (Calcium-binding mitochondrial carrier protein Aralar2) (ARALAR-related gene 2) (ARALAR2) (Citrin) (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:38945283}. |
| Q9UKI2 | CDC42EP3 | S144 | ochoa | Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| Q9UKK3 | PARP4 | S1288 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULC8 | ZDHHC8 | S571 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9UNY4 | TTF2 | S460 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9Y210 | TRPC6 | S322 | psp | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y250 | LZTS1 | S172 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2U5 | MAP3K2 | S514 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y2U8 | LEMD3 | S27 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3D7 | PAM16 | S69 | ochoa | Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16) | Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. {ECO:0000269|PubMed:20053669}. |
| Q9Y572 | RIPK3 | S164 | psp | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y597 | KCTD3 | S602 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y617 | PSAT1 | S331 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| Q9Y6D5 | ARFGEF2 | S1513 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6K9 | IKBKG | S85 | psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| Q9Y6M4 | CSNK1G3 | S413 | ochoa | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
| A0A2R8Y4L2 | HNRNPA1L3 | S22 | Sugiyama | Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) | None |
| Q9Y520 | PRRC2C | S661 | EPSD|PSP | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q07157 | TJP1 | S1360 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q13347 | EIF3I | S197 | Sugiyama | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q14204 | DYNC1H1 | S1313 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| P47712 | PLA2G4A | S178 | Sugiyama | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P52907 | CAPZA1 | S123 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| O60763 | USO1 | S32 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| Q07617 | SPAG1 | S317 | iPTMNet|EPSD | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
| P30566 | ADSL | S412 | Sugiyama | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| P98082 | DAB2 | S241 | Sugiyama | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q9Y490 | TLN1 | S1891 | Sugiyama | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| O14964 | HGS | Y466 | Sugiyama | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
| Q00534 | CDK6 | T282 | Sugiyama | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q14164 | IKBKE | S582 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q16566 | CAMK4 | S58 | Sugiyama | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| O95999 | BCL10 | S85 | Sugiyama | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| Q86UP3 | ZFHX4 | S319 | Sugiyama | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9008059 | Interleukin-37 signaling | 0.000012 | 4.936 |
| R-HSA-390522 | Striated Muscle Contraction | 0.002286 | 2.641 |
| R-HSA-3295583 | TRP channels | 0.001018 | 2.992 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 0.002181 | 2.661 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.001901 | 2.721 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.001739 | 2.760 |
| R-HSA-449147 | Signaling by Interleukins | 0.003279 | 2.484 |
| R-HSA-9646399 | Aggrephagy | 0.004050 | 2.393 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.003948 | 2.404 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.003927 | 2.406 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005436 | 2.265 |
| R-HSA-418346 | Platelet homeostasis | 0.005778 | 2.238 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.005117 | 2.291 |
| R-HSA-9679506 | SARS-CoV Infections | 0.005620 | 2.250 |
| R-HSA-75153 | Apoptotic execution phase | 0.006561 | 2.183 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.026714 | 1.573 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.026714 | 1.573 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.026714 | 1.573 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.026714 | 1.573 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.026714 | 1.573 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.039804 | 1.400 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.039804 | 1.400 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 0.039804 | 1.400 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 0.039804 | 1.400 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 0.039804 | 1.400 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.052718 | 1.278 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.052718 | 1.278 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.052718 | 1.278 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.052718 | 1.278 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.052718 | 1.278 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.052718 | 1.278 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.052718 | 1.278 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.052718 | 1.278 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.052718 | 1.278 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.052718 | 1.278 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.052718 | 1.278 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.052718 | 1.278 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.052718 | 1.278 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.065459 | 1.184 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.078030 | 1.108 |
| R-HSA-210990 | PECAM1 interactions | 0.015790 | 1.802 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.090432 | 1.044 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.090432 | 1.044 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.090432 | 1.044 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.090432 | 1.044 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.102668 | 0.989 |
| R-HSA-447043 | Neurofascin interactions | 0.114741 | 0.940 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.126651 | 0.897 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.126651 | 0.897 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.126651 | 0.897 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.138403 | 0.859 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.138403 | 0.859 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.138403 | 0.859 |
| R-HSA-111995 | phospho-PLA2 pathway | 0.138403 | 0.859 |
| R-HSA-196025 | Formation of annular gap junctions | 0.138403 | 0.859 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.012365 | 1.908 |
| R-HSA-190873 | Gap junction degradation | 0.149996 | 0.824 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.052419 | 1.281 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.052419 | 1.281 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.172720 | 0.763 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.183854 | 0.736 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.194839 | 0.710 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.194839 | 0.710 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.194839 | 0.710 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.194839 | 0.710 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.194839 | 0.710 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.205677 | 0.687 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.205677 | 0.687 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.082203 | 1.085 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.226919 | 0.644 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.226919 | 0.644 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.226919 | 0.644 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.237327 | 0.625 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.237327 | 0.625 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.237327 | 0.625 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.247595 | 0.606 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.247595 | 0.606 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.257726 | 0.589 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.129264 | 0.889 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.267721 | 0.572 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.133806 | 0.874 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.072896 | 1.137 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.072896 | 1.137 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.277582 | 0.557 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.277582 | 0.557 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.080209 | 1.096 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.287310 | 0.542 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.287310 | 0.542 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.287310 | 0.542 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.287310 | 0.542 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.296909 | 0.527 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.009081 | 2.042 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.098435 | 1.007 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.166505 | 0.779 |
| R-HSA-380287 | Centrosome maturation | 0.103925 | 0.983 |
| R-HSA-72172 | mRNA Splicing | 0.012002 | 1.921 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.315721 | 0.501 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.124047 | 0.906 |
| R-HSA-72187 | mRNA 3'-end processing | 0.195498 | 0.709 |
| R-HSA-72649 | Translation initiation complex formation | 0.205303 | 0.688 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.215159 | 0.667 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.145449 | 0.837 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.184615 | 0.734 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.299802 | 0.523 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.008146 | 2.089 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.296909 | 0.527 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.296909 | 0.527 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.257726 | 0.589 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.257726 | 0.589 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.133806 | 0.874 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.133806 | 0.874 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.283894 | 0.547 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.151774 | 0.819 |
| R-HSA-354192 | Integrin signaling | 0.098625 | 1.006 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.296909 | 0.527 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.124759 | 0.904 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.254465 | 0.594 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.120294 | 0.920 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.177898 | 0.750 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.098625 | 1.006 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.090432 | 1.044 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.015367 | 1.813 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.161435 | 0.792 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.055887 | 1.253 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.161749 | 0.791 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.161749 | 0.791 |
| R-HSA-191650 | Regulation of gap junction activity | 0.078030 | 1.108 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.027832 | 1.555 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 0.183854 | 0.736 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.205677 | 0.687 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.082203 | 1.085 |
| R-HSA-9857492 | Protein lipoylation | 0.226919 | 0.644 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.315721 | 0.501 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.277582 | 0.557 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.011073 | 1.956 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.191397 | 0.718 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.027832 | 1.555 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 0.138403 | 0.859 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.042511 | 1.371 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.149996 | 0.824 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.036040 | 1.443 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.086224 | 1.064 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.107153 | 0.970 |
| R-HSA-6783984 | Glycine degradation | 0.247595 | 0.606 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.257726 | 0.589 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.033411 | 1.476 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.020263 | 1.693 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.023216 | 1.634 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.086224 | 1.064 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.078030 | 1.108 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.138403 | 0.859 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.114741 | 0.940 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.107153 | 0.970 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 0.039804 | 1.400 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 0.039804 | 1.400 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.052718 | 1.278 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.078030 | 1.108 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 0.078030 | 1.108 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.102668 | 0.989 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.102668 | 0.989 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.039384 | 1.405 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.205677 | 0.687 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.107153 | 0.970 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.107153 | 0.970 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.247595 | 0.606 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.267721 | 0.572 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.239968 | 0.620 |
| R-HSA-1268020 | Mitochondrial protein import | 0.244949 | 0.611 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.269896 | 0.569 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.279877 | 0.553 |
| R-HSA-5218859 | Regulated Necrosis | 0.085253 | 1.069 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.093289 | 1.030 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.115870 | 0.936 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.039384 | 1.405 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.017967 | 1.746 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.033411 | 1.476 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.308293 | 0.511 |
| R-HSA-112040 | G-protein mediated events | 0.082714 | 1.082 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.161435 | 0.792 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.052419 | 1.281 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.115870 | 0.936 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.063641 | 1.196 |
| R-HSA-202424 | Downstream TCR signaling | 0.151774 | 0.819 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.126651 | 0.897 |
| R-HSA-202403 | TCR signaling | 0.229714 | 0.639 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.009936 | 2.003 |
| R-HSA-2028269 | Signaling by Hippo | 0.036350 | 1.440 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.082203 | 1.085 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.284864 | 0.545 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.086224 | 1.064 |
| R-HSA-5693538 | Homology Directed Repair | 0.105831 | 0.975 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.171252 | 0.766 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.121090 | 0.917 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.186534 | 0.729 |
| R-HSA-68882 | Mitotic Anaphase | 0.217421 | 0.663 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.011807 | 1.928 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.161435 | 0.792 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.055887 | 1.253 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.090430 | 1.044 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.190619 | 0.720 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.098625 | 1.006 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.219843 | 0.658 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.315721 | 0.501 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.084446 | 1.073 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.058736 | 1.231 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.082714 | 1.082 |
| R-HSA-111996 | Ca-dependent events | 0.031151 | 1.507 |
| R-HSA-3214842 | HDMs demethylate histones | 0.066749 | 1.176 |
| R-HSA-9635644 | Inhibition of membrane repair | 0.039804 | 1.400 |
| R-HSA-9675132 | Diseases of cellular response to stress | 0.052718 | 1.278 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 0.052718 | 1.278 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.078030 | 1.108 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.126651 | 0.897 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.138403 | 0.859 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.049032 | 1.310 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.172720 | 0.763 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.063055 | 1.200 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.183854 | 0.736 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.216369 | 0.665 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.216369 | 0.665 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.102864 | 0.988 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.111489 | 0.953 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.247595 | 0.606 |
| R-HSA-9834899 | Specification of the neural plate border | 0.277582 | 0.557 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.296909 | 0.527 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.296909 | 0.527 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.166505 | 0.779 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.101165 | 0.995 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.130038 | 0.886 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.225059 | 0.648 |
| R-HSA-111885 | Opioid Signalling | 0.205146 | 0.688 |
| R-HSA-182971 | EGFR downregulation | 0.014325 | 1.844 |
| R-HSA-112043 | PLC beta mediated events | 0.068197 | 1.166 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.176089 | 0.754 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.220104 | 0.657 |
| R-HSA-111933 | Calmodulin induced events | 0.115870 | 0.936 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.124759 | 0.904 |
| R-HSA-111997 | CaM pathway | 0.115870 | 0.936 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.180913 | 0.743 |
| R-HSA-8953854 | Metabolism of RNA | 0.186492 | 0.729 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.149996 | 0.824 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.149996 | 0.824 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.194839 | 0.710 |
| R-HSA-392517 | Rap1 signalling | 0.277582 | 0.557 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.142692 | 0.846 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.085347 | 1.069 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.039384 | 1.405 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.237327 | 0.625 |
| R-HSA-68886 | M Phase | 0.099239 | 1.003 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.085347 | 1.069 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.257726 | 0.589 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.267721 | 0.572 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.075911 | 1.120 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.048878 | 1.311 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.294827 | 0.530 |
| R-HSA-199991 | Membrane Trafficking | 0.123749 | 0.907 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.090432 | 1.044 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.020263 | 1.693 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.102668 | 0.989 |
| R-HSA-425381 | Bicarbonate transporters | 0.172720 | 0.763 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.070514 | 1.152 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.194839 | 0.710 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.194839 | 0.710 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.194839 | 0.710 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.194839 | 0.710 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.205677 | 0.687 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.216369 | 0.665 |
| R-HSA-163615 | PKA activation | 0.267721 | 0.572 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.277582 | 0.557 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.161749 | 0.791 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.306378 | 0.514 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.195498 | 0.709 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.294827 | 0.530 |
| R-HSA-69481 | G2/M Checkpoints | 0.302229 | 0.520 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.257407 | 0.589 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.106688 | 0.972 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.022688 | 1.644 |
| R-HSA-9663891 | Selective autophagy | 0.043904 | 1.357 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.138384 | 0.859 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.235163 | 0.629 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.032598 | 1.487 |
| R-HSA-9733709 | Cardiogenesis | 0.098625 | 1.006 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.234992 | 0.629 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.086224 | 1.064 |
| R-HSA-9612973 | Autophagy | 0.089293 | 1.049 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.104097 | 0.983 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.020694 | 1.684 |
| R-HSA-397014 | Muscle contraction | 0.014525 | 1.838 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.193182 | 0.714 |
| R-HSA-1640170 | Cell Cycle | 0.021547 | 1.667 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.010009 | 2.000 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.090432 | 1.044 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.017967 | 1.746 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.102668 | 0.989 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.036350 | 1.440 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.172720 | 0.763 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.194839 | 0.710 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.194839 | 0.710 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.194839 | 0.710 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.306378 | 0.514 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.315721 | 0.501 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.205146 | 0.688 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.216951 | 0.664 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.254923 | 0.594 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.189240 | 0.723 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.038639 | 1.413 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.007844 | 2.105 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.157864 | 0.802 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.009732 | 2.012 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.177505 | 0.751 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.111489 | 0.953 |
| R-HSA-877300 | Interferon gamma signaling | 0.034584 | 1.461 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.102668 | 0.989 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 0.138403 | 0.859 |
| R-HSA-5689877 | Josephin domain DUBs | 0.161435 | 0.792 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.205677 | 0.687 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.237327 | 0.625 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.247595 | 0.606 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.257726 | 0.589 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.267721 | 0.572 |
| R-HSA-71288 | Creatine metabolism | 0.287310 | 0.542 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.287310 | 0.542 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.315721 | 0.501 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.319637 | 0.495 |
| R-HSA-73894 | DNA Repair | 0.146422 | 0.834 |
| R-HSA-5357801 | Programmed Cell Death | 0.034790 | 1.459 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.022291 | 1.652 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.254795 | 0.594 |
| R-HSA-69275 | G2/M Transition | 0.147277 | 0.832 |
| R-HSA-8852135 | Protein ubiquitination | 0.103925 | 0.983 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.151474 | 0.820 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.287310 | 0.542 |
| R-HSA-9659379 | Sensory processing of sound | 0.115256 | 0.938 |
| R-HSA-9675135 | Diseases of DNA repair | 0.166505 | 0.779 |
| R-HSA-68875 | Mitotic Prophase | 0.272940 | 0.564 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.077754 | 1.109 |
| R-HSA-1632852 | Macroautophagy | 0.065119 | 1.186 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.216369 | 0.665 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.120294 | 0.920 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.287310 | 0.542 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.085253 | 1.069 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.296909 | 0.527 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.306378 | 0.514 |
| R-HSA-168256 | Immune System | 0.154453 | 0.811 |
| R-HSA-177929 | Signaling by EGFR | 0.057086 | 1.243 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.138384 | 0.859 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.262175 | 0.581 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.090432 | 1.044 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.126651 | 0.897 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.149996 | 0.824 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.082203 | 1.085 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.216369 | 0.665 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.226919 | 0.644 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.237327 | 0.625 |
| R-HSA-977347 | Serine metabolism | 0.306378 | 0.514 |
| R-HSA-9833482 | PKR-mediated signaling | 0.118159 | 0.928 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.215159 | 0.667 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.249934 | 0.602 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.166505 | 0.779 |
| R-HSA-75893 | TNF signaling | 0.215159 | 0.667 |
| R-HSA-913531 | Interferon Signaling | 0.049930 | 1.302 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.008990 | 2.046 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.172720 | 0.763 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.205677 | 0.687 |
| R-HSA-8963896 | HDL assembly | 0.216369 | 0.665 |
| R-HSA-8876725 | Protein methylation | 0.226919 | 0.644 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.102864 | 0.988 |
| R-HSA-4839726 | Chromatin organization | 0.300963 | 0.521 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.022675 | 1.644 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.032739 | 1.485 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.216369 | 0.665 |
| R-HSA-9678110 | Attachment and Entry | 0.237327 | 0.625 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 0.296909 | 0.527 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.124759 | 0.904 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.081507 | 1.089 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.296909 | 0.527 |
| R-HSA-9694614 | Attachment and Entry | 0.306378 | 0.514 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.205731 | 0.687 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.216369 | 0.665 |
| R-HSA-9694548 | Maturation of spike protein | 0.138384 | 0.859 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.287310 | 0.542 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.079619 | 1.099 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.070514 | 1.152 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.277582 | 0.557 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.247585 | 0.606 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.079619 | 1.099 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.195498 | 0.709 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.154970 | 0.810 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.025890 | 1.587 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.017355 | 1.761 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.176089 | 0.754 |
| R-HSA-983712 | Ion channel transport | 0.311325 | 0.507 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.098625 | 1.006 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.018004 | 1.745 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.112375 | 0.949 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.316415 | 0.500 |
| R-HSA-373755 | Semaphorin interactions | 0.249934 | 0.602 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.274887 | 0.561 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.109533 | 0.960 |
| R-HSA-109581 | Apoptosis | 0.228334 | 0.641 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.028193 | 1.550 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.267721 | 0.572 |
| R-HSA-373752 | Netrin-1 signaling | 0.157018 | 0.804 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.161423 | 0.792 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.315721 | 0.501 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.225059 | 0.648 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.162788 | 0.788 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.042552 | 1.371 |
| R-HSA-68877 | Mitotic Prometaphase | 0.323480 | 0.490 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.324939 | 0.488 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.324939 | 0.488 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.324939 | 0.488 |
| R-HSA-200425 | Carnitine shuttle | 0.324939 | 0.488 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.324939 | 0.488 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.334032 | 0.476 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.334032 | 0.476 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.334032 | 0.476 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.334032 | 0.476 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.334032 | 0.476 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.334032 | 0.476 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.334426 | 0.476 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.339336 | 0.469 |
| R-HSA-163685 | Integration of energy metabolism | 0.342702 | 0.465 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.343004 | 0.465 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.343004 | 0.465 |
| R-HSA-9830364 | Formation of the nephric duct | 0.343004 | 0.465 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.343004 | 0.465 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.343004 | 0.465 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.344235 | 0.463 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.344822 | 0.462 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.344822 | 0.462 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.350929 | 0.455 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.351856 | 0.454 |
| R-HSA-525793 | Myogenesis | 0.351856 | 0.454 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.351856 | 0.454 |
| R-HSA-422475 | Axon guidance | 0.359586 | 0.444 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.360589 | 0.443 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.360589 | 0.443 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.360589 | 0.443 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.360589 | 0.443 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.360589 | 0.443 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.360589 | 0.443 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.363708 | 0.439 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.363708 | 0.439 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.368543 | 0.434 |
| R-HSA-5620971 | Pyroptosis | 0.369204 | 0.433 |
| R-HSA-168249 | Innate Immune System | 0.370767 | 0.431 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.372050 | 0.429 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.373364 | 0.428 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.377705 | 0.423 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.377705 | 0.423 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.377705 | 0.423 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.382961 | 0.417 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.386091 | 0.413 |
| R-HSA-2424491 | DAP12 signaling | 0.386091 | 0.413 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.386091 | 0.413 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.386091 | 0.413 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.386091 | 0.413 |
| R-HSA-9824446 | Viral Infection Pathways | 0.386894 | 0.412 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.387546 | 0.412 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.387736 | 0.411 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.394364 | 0.404 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.394364 | 0.404 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.394364 | 0.404 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.394364 | 0.404 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.394364 | 0.404 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.394364 | 0.404 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.394364 | 0.404 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.394364 | 0.404 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.397236 | 0.401 |
| R-HSA-391251 | Protein folding | 0.401962 | 0.396 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.401962 | 0.396 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.402527 | 0.395 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.404765 | 0.393 |
| R-HSA-9609507 | Protein localization | 0.408372 | 0.389 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.410580 | 0.387 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.410580 | 0.387 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.410580 | 0.387 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.410580 | 0.387 |
| R-HSA-9930044 | Nuclear RNA decay | 0.410580 | 0.387 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.410580 | 0.387 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.410580 | 0.387 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.410580 | 0.387 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.410580 | 0.387 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.410580 | 0.387 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.418525 | 0.378 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.418525 | 0.378 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.418525 | 0.378 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.418525 | 0.378 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.418525 | 0.378 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.418525 | 0.378 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.420684 | 0.376 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.426364 | 0.370 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.426364 | 0.370 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.426364 | 0.370 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.426364 | 0.370 |
| R-HSA-392518 | Signal amplification | 0.426364 | 0.370 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.426907 | 0.370 |
| R-HSA-9675108 | Nervous system development | 0.430660 | 0.366 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.434097 | 0.362 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.434097 | 0.362 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.434097 | 0.362 |
| R-HSA-422356 | Regulation of insulin secretion | 0.434529 | 0.362 |
| R-HSA-3371511 | HSF1 activation | 0.441726 | 0.355 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.441726 | 0.355 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.441726 | 0.355 |
| R-HSA-72312 | rRNA processing | 0.444871 | 0.352 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.447571 | 0.349 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.449254 | 0.348 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.449254 | 0.348 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.449254 | 0.348 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.452709 | 0.344 |
| R-HSA-1483255 | PI Metabolism | 0.452709 | 0.344 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.456680 | 0.340 |
| R-HSA-5663205 | Infectious disease | 0.460261 | 0.337 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.464006 | 0.333 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.464006 | 0.333 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.464006 | 0.333 |
| R-HSA-201556 | Signaling by ALK | 0.464006 | 0.333 |
| R-HSA-6798695 | Neutrophil degranulation | 0.470036 | 0.328 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.471234 | 0.327 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.471234 | 0.327 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.471234 | 0.327 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.471234 | 0.327 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.471234 | 0.327 |
| R-HSA-5260271 | Diseases of Immune System | 0.471234 | 0.327 |
| R-HSA-202433 | Generation of second messenger molecules | 0.471234 | 0.327 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.471234 | 0.327 |
| R-HSA-1280218 | Adaptive Immune System | 0.478200 | 0.320 |
| R-HSA-1500931 | Cell-Cell communication | 0.478209 | 0.320 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.478365 | 0.320 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.478365 | 0.320 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.478365 | 0.320 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.478365 | 0.320 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.478365 | 0.320 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.478365 | 0.320 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.478365 | 0.320 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.482289 | 0.317 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.483708 | 0.315 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.483708 | 0.315 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.483708 | 0.315 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.483708 | 0.315 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.485400 | 0.314 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.485400 | 0.314 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.485400 | 0.314 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.485400 | 0.314 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.488048 | 0.312 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.488048 | 0.312 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.488509 | 0.311 |
| R-HSA-991365 | Activation of GABAB receptors | 0.492341 | 0.308 |
| R-HSA-977444 | GABA B receptor activation | 0.492341 | 0.308 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.492341 | 0.308 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.492341 | 0.308 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.492341 | 0.308 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.492341 | 0.308 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.492341 | 0.308 |
| R-HSA-112316 | Neuronal System | 0.493772 | 0.306 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.496188 | 0.304 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.499189 | 0.302 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.499189 | 0.302 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.499189 | 0.302 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.500930 | 0.300 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.500930 | 0.300 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.505178 | 0.297 |
| R-HSA-69236 | G1 Phase | 0.505944 | 0.296 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.505944 | 0.296 |
| R-HSA-2172127 | DAP12 interactions | 0.505944 | 0.296 |
| R-HSA-190828 | Gap junction trafficking | 0.505944 | 0.296 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.505944 | 0.296 |
| R-HSA-5683826 | Surfactant metabolism | 0.505944 | 0.296 |
| R-HSA-597592 | Post-translational protein modification | 0.509812 | 0.293 |
| R-HSA-5688426 | Deubiquitination | 0.511912 | 0.291 |
| R-HSA-774815 | Nucleosome assembly | 0.512609 | 0.290 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.512609 | 0.290 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.512609 | 0.290 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.512609 | 0.290 |
| R-HSA-9824272 | Somitogenesis | 0.512609 | 0.290 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.512609 | 0.290 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.512609 | 0.290 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.514747 | 0.288 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.517781 | 0.286 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.519185 | 0.285 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.519185 | 0.285 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.519185 | 0.285 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.519185 | 0.285 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.519185 | 0.285 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.519185 | 0.285 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.519185 | 0.285 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.525672 | 0.279 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.525672 | 0.279 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.526065 | 0.279 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.526065 | 0.279 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.530171 | 0.276 |
| R-HSA-9634597 | GPER1 signaling | 0.532072 | 0.274 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.534378 | 0.272 |
| R-HSA-9766229 | Degradation of CDH1 | 0.538386 | 0.269 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.538386 | 0.269 |
| R-HSA-73893 | DNA Damage Bypass | 0.538386 | 0.269 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.538386 | 0.269 |
| R-HSA-5617833 | Cilium Assembly | 0.538808 | 0.269 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.546351 | 0.263 |
| R-HSA-73886 | Chromosome Maintenance | 0.546351 | 0.263 |
| R-HSA-3371556 | Cellular response to heat stress | 0.546351 | 0.263 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.550761 | 0.259 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.554295 | 0.256 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.556120 | 0.255 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.556824 | 0.254 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.556824 | 0.254 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.556824 | 0.254 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.558231 | 0.253 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.558231 | 0.253 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.562805 | 0.250 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.562805 | 0.250 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.562805 | 0.250 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.562805 | 0.250 |
| R-HSA-1221632 | Meiotic synapsis | 0.562805 | 0.250 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.562805 | 0.250 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.568707 | 0.245 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.568707 | 0.245 |
| R-HSA-114608 | Platelet degranulation | 0.573724 | 0.241 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.574528 | 0.241 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.574528 | 0.241 |
| R-HSA-418597 | G alpha (z) signalling events | 0.574528 | 0.241 |
| R-HSA-446728 | Cell junction organization | 0.575070 | 0.240 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.579581 | 0.237 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.579581 | 0.237 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.580272 | 0.236 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.585939 | 0.232 |
| R-HSA-1483166 | Synthesis of PA | 0.585939 | 0.232 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.591529 | 0.228 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.591529 | 0.228 |
| R-HSA-9843745 | Adipogenesis | 0.592533 | 0.227 |
| R-HSA-191859 | snRNP Assembly | 0.597044 | 0.224 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.597044 | 0.224 |
| R-HSA-9033241 | Peroxisomal protein import | 0.597044 | 0.224 |
| R-HSA-4085001 | Sialic acid metabolism | 0.597044 | 0.224 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.597044 | 0.224 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.599882 | 0.222 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.602485 | 0.220 |
| R-HSA-977443 | GABA receptor activation | 0.602485 | 0.220 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.602485 | 0.220 |
| R-HSA-379724 | tRNA Aminoacylation | 0.602485 | 0.220 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.607853 | 0.216 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.607853 | 0.216 |
| R-HSA-450294 | MAP kinase activation | 0.607853 | 0.216 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.607853 | 0.216 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.609367 | 0.215 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.613149 | 0.212 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.613149 | 0.212 |
| R-HSA-9707616 | Heme signaling | 0.613149 | 0.212 |
| R-HSA-186797 | Signaling by PDGF | 0.613149 | 0.212 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.613149 | 0.212 |
| R-HSA-162582 | Signal Transduction | 0.614366 | 0.212 |
| R-HSA-1483257 | Phospholipid metabolism | 0.618686 | 0.209 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.621332 | 0.207 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.621332 | 0.207 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.623528 | 0.205 |
| R-HSA-418990 | Adherens junctions interactions | 0.626554 | 0.203 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.628283 | 0.202 |
| R-HSA-9664407 | Parasite infection | 0.628283 | 0.202 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.628283 | 0.202 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.628613 | 0.202 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.631721 | 0.199 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.633629 | 0.198 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.638524 | 0.195 |
| R-HSA-9830369 | Kidney development | 0.638579 | 0.195 |
| R-HSA-196807 | Nicotinate metabolism | 0.638579 | 0.195 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.645228 | 0.190 |
| R-HSA-162906 | HIV Infection | 0.651354 | 0.186 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.653030 | 0.185 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.653030 | 0.185 |
| R-HSA-448424 | Interleukin-17 signaling | 0.653030 | 0.185 |
| R-HSA-109582 | Hemostasis | 0.653715 | 0.185 |
| R-HSA-2262752 | Cellular responses to stress | 0.654747 | 0.184 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.655474 | 0.183 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.657719 | 0.182 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.657719 | 0.182 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.657719 | 0.182 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.657719 | 0.182 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.662344 | 0.179 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.662344 | 0.179 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.664753 | 0.177 |
| R-HSA-4086398 | Ca2+ pathway | 0.666907 | 0.176 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.666907 | 0.176 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.666907 | 0.176 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.667922 | 0.175 |
| R-HSA-392499 | Metabolism of proteins | 0.668470 | 0.175 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.671067 | 0.173 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.671408 | 0.173 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.671408 | 0.173 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.675849 | 0.170 |
| R-HSA-73887 | Death Receptor Signaling | 0.677285 | 0.169 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.680231 | 0.167 |
| R-HSA-5689603 | UCH proteinases | 0.680231 | 0.167 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.680358 | 0.167 |
| R-HSA-9610379 | HCMV Late Events | 0.686433 | 0.163 |
| R-HSA-162587 | HIV Life Cycle | 0.686433 | 0.163 |
| R-HSA-5619084 | ABC transporter disorders | 0.688817 | 0.162 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.688817 | 0.162 |
| R-HSA-216083 | Integrin cell surface interactions | 0.688817 | 0.162 |
| R-HSA-418594 | G alpha (i) signalling events | 0.689911 | 0.161 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.695368 | 0.158 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.697174 | 0.157 |
| R-HSA-6806834 | Signaling by MET | 0.697174 | 0.157 |
| R-HSA-977225 | Amyloid fiber formation | 0.701269 | 0.154 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.701269 | 0.154 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.702204 | 0.154 |
| R-HSA-1643685 | Disease | 0.706414 | 0.151 |
| R-HSA-9609646 | HCMV Infection | 0.709326 | 0.149 |
| R-HSA-421270 | Cell-cell junction organization | 0.711671 | 0.148 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.713224 | 0.147 |
| R-HSA-5619102 | SLC transporter disorders | 0.715403 | 0.145 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.717102 | 0.144 |
| R-HSA-1500620 | Meiosis | 0.717102 | 0.144 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.717102 | 0.144 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.720928 | 0.142 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.720928 | 0.142 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.724703 | 0.140 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.724703 | 0.140 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.728427 | 0.138 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.731688 | 0.136 |
| R-HSA-156902 | Peptide chain elongation | 0.732100 | 0.135 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.732100 | 0.135 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.734325 | 0.134 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.734325 | 0.134 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.736939 | 0.133 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.739532 | 0.131 |
| R-HSA-416476 | G alpha (q) signalling events | 0.740847 | 0.130 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.742827 | 0.129 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.746307 | 0.127 |
| R-HSA-168255 | Influenza Infection | 0.749686 | 0.125 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.749739 | 0.125 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.749739 | 0.125 |
| R-HSA-2559583 | Cellular Senescence | 0.752171 | 0.124 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.753126 | 0.123 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.753126 | 0.123 |
| R-HSA-1474290 | Collagen formation | 0.756467 | 0.121 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.757951 | 0.120 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.759763 | 0.119 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.763014 | 0.117 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.763014 | 0.117 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.766640 | 0.115 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.769387 | 0.114 |
| R-HSA-157579 | Telomere Maintenance | 0.769387 | 0.114 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.769387 | 0.114 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.772509 | 0.112 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.772509 | 0.112 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.772509 | 0.112 |
| R-HSA-190236 | Signaling by FGFR | 0.772509 | 0.112 |
| R-HSA-9658195 | Leishmania infection | 0.775423 | 0.110 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.775423 | 0.110 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.778627 | 0.109 |
| R-HSA-70171 | Glycolysis | 0.778627 | 0.109 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.778627 | 0.109 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.781624 | 0.107 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.781624 | 0.107 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.784581 | 0.105 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.784581 | 0.105 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.784581 | 0.105 |
| R-HSA-192823 | Viral mRNA Translation | 0.787498 | 0.104 |
| R-HSA-9609690 | HCMV Early Events | 0.789132 | 0.103 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.789132 | 0.103 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.790376 | 0.102 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.798392 | 0.098 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.801504 | 0.096 |
| R-HSA-69239 | Synthesis of DNA | 0.801504 | 0.096 |
| R-HSA-211000 | Gene Silencing by RNA | 0.801504 | 0.096 |
| R-HSA-1266738 | Developmental Biology | 0.802329 | 0.096 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.803724 | 0.095 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.804193 | 0.095 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.806846 | 0.093 |
| R-HSA-6805567 | Keratinization | 0.811656 | 0.091 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.814591 | 0.089 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.826819 | 0.083 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.826819 | 0.083 |
| R-HSA-373760 | L1CAM interactions | 0.829166 | 0.081 |
| R-HSA-70326 | Glucose metabolism | 0.831482 | 0.080 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.831482 | 0.080 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.831482 | 0.080 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.836020 | 0.078 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.836020 | 0.078 |
| R-HSA-8951664 | Neddylation | 0.838917 | 0.076 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.842600 | 0.074 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.842600 | 0.074 |
| R-HSA-194138 | Signaling by VEGF | 0.850967 | 0.070 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.851956 | 0.070 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.852988 | 0.069 |
| R-HSA-72766 | Translation | 0.860532 | 0.065 |
| R-HSA-1474165 | Reproduction | 0.862694 | 0.064 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.864030 | 0.063 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.864557 | 0.063 |
| R-HSA-9909396 | Circadian clock | 0.866395 | 0.062 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.869661 | 0.061 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.875219 | 0.058 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.875219 | 0.058 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.875579 | 0.058 |
| R-HSA-6807070 | PTEN Regulation | 0.880232 | 0.055 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.892642 | 0.049 |
| R-HSA-2187338 | Visual phototransduction | 0.894101 | 0.049 |
| R-HSA-69242 | S Phase | 0.895540 | 0.048 |
| R-HSA-9758941 | Gastrulation | 0.896959 | 0.047 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.898359 | 0.047 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.898359 | 0.047 |
| R-HSA-2142753 | Arachidonate metabolism | 0.901102 | 0.045 |
| R-HSA-69306 | DNA Replication | 0.902446 | 0.045 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.902781 | 0.044 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.907643 | 0.042 |
| R-HSA-9711097 | Cellular response to starvation | 0.908898 | 0.041 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.911358 | 0.040 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.916082 | 0.038 |
| R-HSA-388396 | GPCR downstream signalling | 0.916506 | 0.038 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.916678 | 0.038 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.922909 | 0.035 |
| R-HSA-72306 | tRNA processing | 0.923754 | 0.034 |
| R-HSA-418555 | G alpha (s) signalling events | 0.924791 | 0.034 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.926824 | 0.033 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.926824 | 0.033 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.928700 | 0.032 |
| R-HSA-382551 | Transport of small molecules | 0.929781 | 0.032 |
| R-HSA-611105 | Respiratory electron transport | 0.931670 | 0.031 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.935821 | 0.029 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.936196 | 0.029 |
| R-HSA-74160 | Gene expression (Transcription) | 0.942099 | 0.026 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.944373 | 0.025 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.947419 | 0.023 |
| R-HSA-1474244 | Extracellular matrix organization | 0.952002 | 0.021 |
| R-HSA-372790 | Signaling by GPCR | 0.955512 | 0.020 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.960827 | 0.017 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.966803 | 0.015 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.966992 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.967187 | 0.014 |
| R-HSA-15869 | Metabolism of nucleotides | 0.969607 | 0.013 |
| R-HSA-8939211 | ESR-mediated signaling | 0.970022 | 0.013 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.977174 | 0.010 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.977967 | 0.010 |
| R-HSA-8978868 | Fatty acid metabolism | 0.980425 | 0.009 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.986522 | 0.006 |
| R-HSA-195721 | Signaling by WNT | 0.987069 | 0.006 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.988977 | 0.005 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.990232 | 0.004 |
| R-HSA-212436 | Generic Transcription Pathway | 0.991669 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.992865 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 0.997885 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999882 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999988 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999994 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999996 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.873 | 0.105 | 2 | 0.901 |
CLK3 |
0.869 | 0.173 | 1 | 0.877 |
MOS |
0.860 | 0.109 | 1 | 0.948 |
PIM3 |
0.859 | 0.084 | -3 | 0.836 |
CDC7 |
0.859 | 0.079 | 1 | 0.913 |
NDR2 |
0.859 | 0.057 | -3 | 0.834 |
NLK |
0.858 | 0.188 | 1 | 0.875 |
PRPK |
0.855 | -0.030 | -1 | 0.641 |
GCN2 |
0.855 | -0.002 | 2 | 0.816 |
RSK2 |
0.855 | 0.111 | -3 | 0.791 |
DSTYK |
0.854 | 0.038 | 2 | 0.911 |
RAF1 |
0.854 | -0.004 | 1 | 0.882 |
CAMK1B |
0.854 | 0.058 | -3 | 0.865 |
PIM1 |
0.853 | 0.119 | -3 | 0.791 |
NDR1 |
0.853 | 0.068 | -3 | 0.841 |
PRKD2 |
0.853 | 0.123 | -3 | 0.786 |
MTOR |
0.852 | -0.048 | 1 | 0.855 |
PRKD1 |
0.852 | 0.090 | -3 | 0.821 |
IKKB |
0.851 | -0.018 | -2 | 0.733 |
SRPK1 |
0.851 | 0.107 | -3 | 0.758 |
CDKL1 |
0.850 | 0.065 | -3 | 0.805 |
AURC |
0.850 | 0.146 | -2 | 0.743 |
WNK1 |
0.850 | 0.079 | -2 | 0.913 |
SKMLCK |
0.850 | 0.104 | -2 | 0.915 |
NEK6 |
0.850 | 0.030 | -2 | 0.877 |
PKN3 |
0.850 | 0.056 | -3 | 0.824 |
CAMK2G |
0.850 | 0.003 | 2 | 0.854 |
MST4 |
0.849 | 0.068 | 2 | 0.850 |
BMPR2 |
0.849 | 0.011 | -2 | 0.883 |
TBK1 |
0.849 | -0.021 | 1 | 0.780 |
ERK5 |
0.848 | 0.107 | 1 | 0.861 |
PDHK4 |
0.848 | -0.135 | 1 | 0.900 |
P90RSK |
0.848 | 0.074 | -3 | 0.788 |
CAMLCK |
0.847 | 0.118 | -2 | 0.892 |
NIK |
0.847 | 0.052 | -3 | 0.879 |
RSK3 |
0.847 | 0.077 | -3 | 0.781 |
LATS2 |
0.846 | 0.024 | -5 | 0.720 |
PKCD |
0.846 | 0.083 | 2 | 0.797 |
CDKL5 |
0.846 | 0.077 | -3 | 0.797 |
NUAK2 |
0.846 | 0.041 | -3 | 0.844 |
RIPK3 |
0.846 | 0.030 | 3 | 0.765 |
P70S6KB |
0.846 | 0.078 | -3 | 0.812 |
NEK7 |
0.846 | -0.011 | -3 | 0.827 |
TGFBR2 |
0.845 | 0.032 | -2 | 0.800 |
ATR |
0.845 | 0.004 | 1 | 0.844 |
ULK2 |
0.845 | -0.090 | 2 | 0.792 |
DAPK2 |
0.844 | 0.103 | -3 | 0.868 |
IKKE |
0.844 | -0.033 | 1 | 0.772 |
PKACG |
0.844 | 0.081 | -2 | 0.807 |
PKN2 |
0.844 | 0.053 | -3 | 0.841 |
MAPKAPK3 |
0.843 | 0.074 | -3 | 0.790 |
ICK |
0.843 | 0.061 | -3 | 0.835 |
CLK2 |
0.843 | 0.164 | -3 | 0.766 |
SRPK2 |
0.842 | 0.085 | -3 | 0.691 |
MAPKAPK2 |
0.842 | 0.076 | -3 | 0.751 |
CLK4 |
0.842 | 0.134 | -3 | 0.783 |
HIPK4 |
0.842 | 0.055 | 1 | 0.826 |
PKACB |
0.841 | 0.129 | -2 | 0.761 |
PDHK1 |
0.841 | -0.139 | 1 | 0.879 |
CAMK2D |
0.841 | 0.030 | -3 | 0.847 |
GRK1 |
0.841 | 0.046 | -2 | 0.779 |
AURB |
0.841 | 0.141 | -2 | 0.738 |
AMPKA1 |
0.841 | 0.021 | -3 | 0.853 |
CLK1 |
0.840 | 0.142 | -3 | 0.768 |
MLK1 |
0.840 | -0.031 | 2 | 0.822 |
PAK1 |
0.840 | 0.082 | -2 | 0.837 |
CAMK2B |
0.840 | 0.077 | 2 | 0.847 |
FAM20C |
0.840 | 0.098 | 2 | 0.698 |
WNK3 |
0.839 | -0.036 | 1 | 0.851 |
RSK4 |
0.839 | 0.094 | -3 | 0.753 |
PRKX |
0.839 | 0.135 | -3 | 0.704 |
MSK2 |
0.839 | 0.054 | -3 | 0.749 |
GRK5 |
0.839 | -0.086 | -3 | 0.823 |
KIS |
0.838 | 0.052 | 1 | 0.745 |
GRK6 |
0.838 | 0.012 | 1 | 0.875 |
MARK4 |
0.838 | -0.031 | 4 | 0.852 |
LATS1 |
0.838 | 0.044 | -3 | 0.854 |
MSK1 |
0.838 | 0.106 | -3 | 0.756 |
IKKA |
0.837 | -0.024 | -2 | 0.720 |
AURA |
0.837 | 0.130 | -2 | 0.713 |
HUNK |
0.837 | -0.119 | 2 | 0.828 |
PRKD3 |
0.837 | 0.083 | -3 | 0.758 |
MNK2 |
0.837 | 0.079 | -2 | 0.861 |
PAK3 |
0.837 | 0.065 | -2 | 0.832 |
TSSK1 |
0.837 | 0.036 | -3 | 0.868 |
CHAK2 |
0.836 | -0.057 | -1 | 0.629 |
TSSK2 |
0.836 | 0.025 | -5 | 0.764 |
DYRK2 |
0.836 | 0.087 | 1 | 0.741 |
AMPKA2 |
0.836 | 0.030 | -3 | 0.828 |
BMPR1B |
0.836 | 0.098 | 1 | 0.837 |
NEK9 |
0.836 | -0.002 | 2 | 0.842 |
CAMK4 |
0.836 | 0.028 | -3 | 0.829 |
MYLK4 |
0.836 | 0.129 | -2 | 0.835 |
SRPK3 |
0.835 | 0.072 | -3 | 0.726 |
CAMK2A |
0.835 | 0.043 | 2 | 0.847 |
PAK6 |
0.835 | 0.125 | -2 | 0.758 |
BCKDK |
0.834 | -0.132 | -1 | 0.597 |
TGFBR1 |
0.834 | 0.059 | -2 | 0.793 |
ATM |
0.834 | 0.009 | 1 | 0.779 |
MNK1 |
0.834 | 0.073 | -2 | 0.861 |
PKR |
0.833 | 0.073 | 1 | 0.864 |
CDK8 |
0.833 | 0.044 | 1 | 0.707 |
MASTL |
0.833 | -0.142 | -2 | 0.821 |
PKCB |
0.833 | 0.036 | 2 | 0.742 |
MLK3 |
0.833 | 0.012 | 2 | 0.749 |
SMG1 |
0.833 | 0.219 | 1 | 0.789 |
ULK1 |
0.833 | -0.146 | -3 | 0.788 |
AKT2 |
0.833 | 0.096 | -3 | 0.710 |
GRK4 |
0.833 | -0.067 | -2 | 0.822 |
ALK4 |
0.833 | 0.037 | -2 | 0.816 |
PKG2 |
0.833 | 0.116 | -2 | 0.752 |
ANKRD3 |
0.832 | -0.076 | 1 | 0.877 |
MELK |
0.832 | 0.041 | -3 | 0.820 |
PKCG |
0.831 | 0.018 | 2 | 0.745 |
MLK2 |
0.831 | -0.055 | 2 | 0.817 |
PIM2 |
0.831 | 0.098 | -3 | 0.764 |
NIM1 |
0.831 | -0.053 | 3 | 0.774 |
DLK |
0.831 | -0.115 | 1 | 0.858 |
PKCA |
0.831 | 0.039 | 2 | 0.736 |
ALK2 |
0.831 | 0.089 | -2 | 0.801 |
PAK2 |
0.830 | 0.061 | -2 | 0.819 |
SGK3 |
0.830 | 0.084 | -3 | 0.777 |
CDK7 |
0.830 | 0.039 | 1 | 0.726 |
RIPK1 |
0.829 | -0.097 | 1 | 0.836 |
PLK1 |
0.829 | -0.023 | -2 | 0.822 |
NUAK1 |
0.829 | -0.009 | -3 | 0.804 |
GRK7 |
0.829 | 0.030 | 1 | 0.827 |
IRE1 |
0.829 | -0.058 | 1 | 0.816 |
ACVR2B |
0.828 | 0.058 | -2 | 0.788 |
PHKG1 |
0.828 | 0.009 | -3 | 0.838 |
JNK2 |
0.828 | 0.101 | 1 | 0.666 |
PKCZ |
0.828 | -0.003 | 2 | 0.782 |
PKCH |
0.827 | 0.026 | 2 | 0.728 |
CDK1 |
0.827 | 0.060 | 1 | 0.677 |
IRE2 |
0.827 | -0.035 | 2 | 0.740 |
YSK4 |
0.827 | -0.023 | 1 | 0.817 |
CDK19 |
0.827 | 0.038 | 1 | 0.665 |
TTBK2 |
0.827 | -0.101 | 2 | 0.718 |
PKACA |
0.827 | 0.114 | -2 | 0.711 |
P38A |
0.826 | 0.086 | 1 | 0.759 |
CDK5 |
0.826 | 0.057 | 1 | 0.743 |
DCAMKL1 |
0.826 | 0.044 | -3 | 0.802 |
PLK3 |
0.826 | -0.015 | 2 | 0.812 |
JNK3 |
0.825 | 0.074 | 1 | 0.710 |
ACVR2A |
0.825 | 0.025 | -2 | 0.777 |
QSK |
0.825 | -0.017 | 4 | 0.833 |
BRSK1 |
0.825 | -0.000 | -3 | 0.803 |
HIPK1 |
0.825 | 0.081 | 1 | 0.758 |
MEK1 |
0.825 | -0.046 | 2 | 0.837 |
QIK |
0.825 | -0.053 | -3 | 0.840 |
NEK2 |
0.824 | -0.028 | 2 | 0.805 |
HIPK2 |
0.824 | 0.082 | 1 | 0.657 |
SIK |
0.824 | -0.010 | -3 | 0.776 |
AKT1 |
0.824 | 0.110 | -3 | 0.731 |
CAMK1G |
0.824 | 0.016 | -3 | 0.777 |
CDK13 |
0.824 | 0.031 | 1 | 0.702 |
CHK1 |
0.824 | 0.002 | -3 | 0.835 |
DRAK1 |
0.823 | 0.012 | 1 | 0.786 |
VRK2 |
0.823 | -0.065 | 1 | 0.901 |
MLK4 |
0.822 | -0.056 | 2 | 0.731 |
CDK18 |
0.822 | 0.041 | 1 | 0.655 |
P38B |
0.822 | 0.081 | 1 | 0.689 |
CHAK1 |
0.822 | -0.060 | 2 | 0.757 |
BRSK2 |
0.822 | -0.025 | -3 | 0.830 |
DNAPK |
0.821 | -0.003 | 1 | 0.719 |
ERK1 |
0.821 | 0.067 | 1 | 0.677 |
MAPKAPK5 |
0.821 | -0.016 | -3 | 0.737 |
CDK2 |
0.821 | 0.044 | 1 | 0.758 |
DYRK4 |
0.821 | 0.085 | 1 | 0.670 |
PRP4 |
0.820 | 0.086 | -3 | 0.791 |
DYRK1A |
0.820 | 0.057 | 1 | 0.790 |
ERK2 |
0.820 | 0.055 | 1 | 0.725 |
BMPR1A |
0.820 | 0.081 | 1 | 0.822 |
P38G |
0.820 | 0.066 | 1 | 0.592 |
PERK |
0.819 | -0.022 | -2 | 0.823 |
DYRK3 |
0.819 | 0.096 | 1 | 0.757 |
WNK4 |
0.819 | -0.016 | -2 | 0.898 |
P70S6K |
0.819 | 0.046 | -3 | 0.728 |
SNRK |
0.819 | -0.064 | 2 | 0.683 |
TAO3 |
0.819 | 0.027 | 1 | 0.837 |
SMMLCK |
0.819 | 0.061 | -3 | 0.825 |
PKCT |
0.818 | 0.027 | 2 | 0.735 |
MARK3 |
0.818 | -0.023 | 4 | 0.793 |
DYRK1B |
0.818 | 0.064 | 1 | 0.702 |
TLK2 |
0.817 | -0.079 | 1 | 0.811 |
CDK12 |
0.817 | 0.033 | 1 | 0.672 |
MARK2 |
0.817 | -0.029 | 4 | 0.754 |
CDK3 |
0.817 | 0.080 | 1 | 0.620 |
HRI |
0.817 | -0.068 | -2 | 0.844 |
MST3 |
0.817 | 0.038 | 2 | 0.831 |
BRAF |
0.817 | -0.068 | -4 | 0.857 |
CAMK1D |
0.817 | 0.051 | -3 | 0.716 |
CDK9 |
0.817 | 0.021 | 1 | 0.707 |
HIPK3 |
0.816 | 0.059 | 1 | 0.766 |
NEK5 |
0.816 | 0.004 | 1 | 0.855 |
DCAMKL2 |
0.816 | 0.013 | -3 | 0.829 |
CDK14 |
0.816 | 0.064 | 1 | 0.696 |
PAK5 |
0.816 | 0.085 | -2 | 0.704 |
CDK10 |
0.816 | 0.081 | 1 | 0.680 |
DAPK3 |
0.816 | 0.102 | -3 | 0.813 |
PASK |
0.815 | -0.002 | -3 | 0.841 |
CDK17 |
0.815 | 0.029 | 1 | 0.600 |
PHKG2 |
0.815 | 0.016 | -3 | 0.816 |
MEKK1 |
0.814 | -0.104 | 1 | 0.833 |
PINK1 |
0.814 | -0.059 | 1 | 0.862 |
PAK4 |
0.814 | 0.085 | -2 | 0.716 |
IRAK4 |
0.814 | -0.038 | 1 | 0.817 |
MRCKA |
0.813 | 0.138 | -3 | 0.780 |
PLK4 |
0.813 | -0.090 | 2 | 0.633 |
MEK5 |
0.813 | -0.140 | 2 | 0.824 |
ERK7 |
0.813 | 0.077 | 2 | 0.559 |
MEKK3 |
0.812 | -0.120 | 1 | 0.832 |
MRCKB |
0.812 | 0.137 | -3 | 0.757 |
TAO2 |
0.812 | 0.036 | 2 | 0.853 |
AKT3 |
0.812 | 0.093 | -3 | 0.650 |
PKCI |
0.812 | 0.016 | 2 | 0.743 |
CDK16 |
0.811 | 0.055 | 1 | 0.622 |
GAK |
0.811 | 0.051 | 1 | 0.886 |
MARK1 |
0.811 | -0.056 | 4 | 0.815 |
ZAK |
0.811 | -0.124 | 1 | 0.803 |
MEKK2 |
0.811 | -0.078 | 2 | 0.803 |
PKCE |
0.810 | 0.054 | 2 | 0.726 |
SSTK |
0.810 | -0.017 | 4 | 0.822 |
SGK1 |
0.810 | 0.086 | -3 | 0.636 |
GRK2 |
0.809 | -0.082 | -2 | 0.703 |
NEK8 |
0.809 | -0.029 | 2 | 0.819 |
MPSK1 |
0.809 | 0.001 | 1 | 0.828 |
DAPK1 |
0.809 | 0.091 | -3 | 0.792 |
GSK3A |
0.809 | 0.030 | 4 | 0.493 |
P38D |
0.808 | 0.067 | 1 | 0.609 |
ROCK2 |
0.808 | 0.119 | -3 | 0.801 |
CK2A2 |
0.807 | 0.066 | 1 | 0.785 |
GSK3B |
0.806 | 0.003 | 4 | 0.485 |
TLK1 |
0.805 | -0.124 | -2 | 0.833 |
CAMKK1 |
0.805 | -0.073 | -2 | 0.755 |
LKB1 |
0.805 | -0.048 | -3 | 0.832 |
GCK |
0.804 | 0.010 | 1 | 0.826 |
PKN1 |
0.804 | 0.033 | -3 | 0.750 |
PDK1 |
0.804 | -0.023 | 1 | 0.843 |
CAMK1A |
0.804 | 0.058 | -3 | 0.680 |
CK1E |
0.804 | -0.063 | -3 | 0.492 |
CDK6 |
0.803 | 0.069 | 1 | 0.678 |
CHK2 |
0.803 | 0.051 | -3 | 0.669 |
TTBK1 |
0.803 | -0.078 | 2 | 0.641 |
TAK1 |
0.803 | 0.068 | 1 | 0.854 |
IRAK1 |
0.803 | -0.156 | -1 | 0.580 |
TNIK |
0.803 | 0.030 | 3 | 0.873 |
LOK |
0.802 | 0.040 | -2 | 0.793 |
CDK4 |
0.802 | 0.070 | 1 | 0.659 |
MAK |
0.802 | 0.079 | -2 | 0.761 |
CAMKK2 |
0.801 | -0.083 | -2 | 0.754 |
MST2 |
0.801 | -0.044 | 1 | 0.837 |
HPK1 |
0.801 | 0.035 | 1 | 0.809 |
NEK11 |
0.801 | -0.134 | 1 | 0.824 |
EEF2K |
0.800 | 0.001 | 3 | 0.842 |
HGK |
0.800 | -0.005 | 3 | 0.872 |
DMPK1 |
0.800 | 0.117 | -3 | 0.784 |
NEK4 |
0.800 | -0.050 | 1 | 0.815 |
MEKK6 |
0.799 | -0.066 | 1 | 0.828 |
MINK |
0.798 | -0.019 | 1 | 0.817 |
SBK |
0.798 | 0.050 | -3 | 0.605 |
JNK1 |
0.798 | 0.039 | 1 | 0.660 |
MOK |
0.798 | 0.071 | 1 | 0.774 |
NEK1 |
0.798 | -0.003 | 1 | 0.831 |
PLK2 |
0.798 | -0.021 | -3 | 0.785 |
CK2A1 |
0.797 | 0.054 | 1 | 0.759 |
SLK |
0.797 | -0.026 | -2 | 0.724 |
PKG1 |
0.797 | 0.080 | -2 | 0.676 |
BUB1 |
0.796 | 0.089 | -5 | 0.736 |
ROCK1 |
0.796 | 0.110 | -3 | 0.775 |
LRRK2 |
0.796 | -0.092 | 2 | 0.851 |
KHS1 |
0.796 | 0.027 | 1 | 0.808 |
KHS2 |
0.796 | 0.052 | 1 | 0.815 |
CK1G1 |
0.796 | -0.072 | -3 | 0.490 |
CK1D |
0.796 | -0.053 | -3 | 0.438 |
MAP3K15 |
0.795 | -0.091 | 1 | 0.802 |
VRK1 |
0.795 | -0.004 | 2 | 0.830 |
GRK3 |
0.795 | -0.078 | -2 | 0.660 |
MST1 |
0.793 | -0.070 | 1 | 0.819 |
CRIK |
0.792 | 0.074 | -3 | 0.722 |
YSK1 |
0.792 | -0.024 | 2 | 0.806 |
PDHK3_TYR |
0.792 | 0.144 | 4 | 0.911 |
RIPK2 |
0.791 | -0.106 | 1 | 0.773 |
CK1A2 |
0.791 | -0.066 | -3 | 0.439 |
STK33 |
0.790 | -0.107 | 2 | 0.644 |
PBK |
0.790 | 0.005 | 1 | 0.818 |
MEK2 |
0.789 | -0.087 | 2 | 0.798 |
OSR1 |
0.786 | -0.016 | 2 | 0.797 |
PDHK4_TYR |
0.784 | 0.043 | 2 | 0.896 |
NEK3 |
0.784 | -0.081 | 1 | 0.794 |
TTK |
0.783 | -0.019 | -2 | 0.839 |
TESK1_TYR |
0.783 | -0.013 | 3 | 0.879 |
MAP2K4_TYR |
0.782 | 0.016 | -1 | 0.657 |
TAO1 |
0.781 | 0.001 | 1 | 0.768 |
HASPIN |
0.781 | -0.036 | -1 | 0.509 |
TXK |
0.781 | 0.237 | 1 | 0.868 |
BIKE |
0.780 | 0.051 | 1 | 0.765 |
MAP2K6_TYR |
0.780 | -0.027 | -1 | 0.646 |
MAP2K7_TYR |
0.779 | -0.068 | 2 | 0.869 |
MYO3B |
0.779 | 0.000 | 2 | 0.808 |
LIMK2_TYR |
0.778 | 0.033 | -3 | 0.889 |
PDHK1_TYR |
0.778 | -0.027 | -1 | 0.658 |
EPHA6 |
0.778 | 0.050 | -1 | 0.665 |
EPHB4 |
0.777 | 0.114 | -1 | 0.681 |
BMPR2_TYR |
0.776 | -0.059 | -1 | 0.639 |
ALPHAK3 |
0.776 | -0.054 | -1 | 0.561 |
PINK1_TYR |
0.776 | -0.108 | 1 | 0.892 |
ASK1 |
0.775 | -0.093 | 1 | 0.794 |
PKMYT1_TYR |
0.775 | -0.121 | 3 | 0.859 |
YES1 |
0.774 | 0.110 | -1 | 0.680 |
RET |
0.774 | 0.000 | 1 | 0.844 |
TYRO3 |
0.774 | 0.118 | 3 | 0.813 |
MYO3A |
0.772 | -0.047 | 1 | 0.802 |
ABL2 |
0.772 | 0.078 | -1 | 0.636 |
LCK |
0.771 | 0.122 | -1 | 0.668 |
BLK |
0.770 | 0.132 | -1 | 0.668 |
ITK |
0.769 | 0.124 | -1 | 0.663 |
HCK |
0.769 | 0.109 | -1 | 0.679 |
MST1R |
0.769 | -0.033 | 3 | 0.816 |
TEC |
0.769 | 0.182 | -1 | 0.657 |
LIMK1_TYR |
0.768 | -0.127 | 2 | 0.852 |
SRMS |
0.768 | 0.113 | 1 | 0.886 |
ABL1 |
0.767 | 0.058 | -1 | 0.632 |
TNK2 |
0.767 | 0.084 | 3 | 0.748 |
EPHA4 |
0.767 | 0.040 | 2 | 0.814 |
CSF1R |
0.767 | -0.025 | 3 | 0.801 |
ROS1 |
0.767 | -0.019 | 3 | 0.783 |
DDR1 |
0.767 | -0.072 | 4 | 0.827 |
EPHB3 |
0.767 | 0.086 | -1 | 0.679 |
EPHB1 |
0.766 | 0.083 | 1 | 0.877 |
MERTK |
0.766 | 0.164 | 3 | 0.777 |
EPHB2 |
0.766 | 0.091 | -1 | 0.669 |
TYK2 |
0.766 | -0.113 | 1 | 0.843 |
INSRR |
0.765 | -0.049 | 3 | 0.749 |
BMX |
0.765 | 0.106 | -1 | 0.626 |
FGR |
0.764 | -0.042 | 1 | 0.884 |
YANK3 |
0.764 | -0.078 | 2 | 0.439 |
FER |
0.763 | -0.026 | 1 | 0.909 |
BTK |
0.763 | 0.147 | -1 | 0.680 |
NEK10_TYR |
0.762 | 0.011 | 1 | 0.745 |
JAK3 |
0.762 | -0.119 | 1 | 0.834 |
AXL |
0.762 | 0.075 | 3 | 0.775 |
JAK2 |
0.762 | -0.115 | 1 | 0.835 |
AAK1 |
0.761 | 0.059 | 1 | 0.660 |
FYN |
0.761 | 0.069 | -1 | 0.635 |
STLK3 |
0.760 | -0.124 | 1 | 0.775 |
FGFR2 |
0.759 | -0.100 | 3 | 0.788 |
EPHA7 |
0.759 | 0.059 | 2 | 0.815 |
TEK |
0.759 | 0.011 | 3 | 0.740 |
FLT3 |
0.758 | -0.066 | 3 | 0.805 |
TNK1 |
0.758 | -0.047 | 3 | 0.794 |
KDR |
0.757 | -0.087 | 3 | 0.761 |
LTK |
0.757 | 0.029 | 3 | 0.748 |
EPHA1 |
0.757 | 0.093 | 3 | 0.759 |
KIT |
0.757 | -0.100 | 3 | 0.797 |
PDGFRB |
0.756 | -0.114 | 3 | 0.806 |
WEE1_TYR |
0.756 | -0.024 | -1 | 0.592 |
FRK |
0.755 | 0.076 | -1 | 0.706 |
LYN |
0.755 | 0.056 | 3 | 0.739 |
EPHA5 |
0.753 | 0.046 | 2 | 0.803 |
EPHA3 |
0.753 | -0.022 | 2 | 0.786 |
FGFR1 |
0.753 | -0.125 | 3 | 0.768 |
JAK1 |
0.753 | -0.053 | 1 | 0.786 |
DDR2 |
0.752 | -0.011 | 3 | 0.733 |
CK1A |
0.752 | -0.091 | -3 | 0.347 |
TNNI3K_TYR |
0.752 | -0.087 | 1 | 0.823 |
PTK2B |
0.751 | 0.054 | -1 | 0.645 |
MET |
0.751 | -0.096 | 3 | 0.782 |
FLT1 |
0.751 | -0.112 | -1 | 0.611 |
ALK |
0.751 | -0.048 | 3 | 0.723 |
PTK6 |
0.750 | -0.073 | -1 | 0.592 |
PDGFRA |
0.749 | -0.129 | 3 | 0.812 |
FGFR3 |
0.748 | -0.111 | 3 | 0.759 |
NTRK1 |
0.748 | -0.132 | -1 | 0.623 |
EPHA8 |
0.747 | -0.022 | -1 | 0.640 |
ERBB2 |
0.747 | -0.111 | 1 | 0.807 |
SRC |
0.747 | -0.004 | -1 | 0.637 |
NTRK2 |
0.745 | -0.119 | 3 | 0.759 |
INSR |
0.744 | -0.127 | 3 | 0.735 |
FLT4 |
0.744 | -0.160 | 3 | 0.763 |
MATK |
0.742 | -0.113 | -1 | 0.545 |
NTRK3 |
0.741 | -0.124 | -1 | 0.591 |
PTK2 |
0.740 | -0.035 | -1 | 0.583 |
EGFR |
0.739 | -0.074 | 1 | 0.716 |
EPHA2 |
0.739 | -0.018 | -1 | 0.624 |
CSK |
0.738 | -0.103 | 2 | 0.812 |
CK1G3 |
0.738 | -0.069 | -3 | 0.298 |
SYK |
0.737 | -0.033 | -1 | 0.574 |
FGFR4 |
0.736 | -0.094 | -1 | 0.586 |
MUSK |
0.734 | -0.074 | 1 | 0.719 |
IGF1R |
0.729 | -0.142 | 3 | 0.674 |
YANK2 |
0.728 | -0.107 | 2 | 0.460 |
ERBB4 |
0.724 | -0.069 | 1 | 0.721 |
FES |
0.717 | -0.086 | -1 | 0.582 |
CK1G2 |
0.715 | -0.098 | -3 | 0.399 |
ZAP70 |
0.713 | -0.080 | -1 | 0.505 |