Motif 941 (n=162)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00151 | PDLIM1 | S118 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00418 | EEF2K | S441 | ochoa|psp | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O00571 | DDX3X | S583 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14523 | C2CD2L | S619 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14818 | PSMA7 | S150 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O43310 | CTIF | S236 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
| O43491 | EPB41L2 | S575 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43791 | SPOP | S119 | psp | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed:36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed:37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed:37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed:38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed:38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity). {ECO:0000250|UniProtKB:Q6ZWS8, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:32109420, ECO:0000269|PubMed:37622993, ECO:0000269|PubMed:37796126, ECO:0000269|PubMed:38018242}. |
| O75312 | ZPR1 | S376 | ochoa | Zinc finger protein ZPR1 (Zinc finger protein 259) | Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766, ECO:0000269|PubMed:29851065}. |
| O75665 | OFD1 | S850 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75934 | BCAS2 | S94 | ochoa | Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154}. |
| O75962 | TRIO | S1632 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94992 | HEXIM1 | S97 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95758 | PTBP3 | S169 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| O95759 | TBC1D8 | S1035 | ochoa | TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein) | May act as a GTPase-activating protein for Rab family protein(s). |
| P00387 | CYB5R3 | S82 | ochoa | NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) | Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor. {ECO:0000269|PubMed:10807796, ECO:0000269|PubMed:1400360, ECO:0000269|PubMed:15953014, ECO:0000269|PubMed:1898726, ECO:0000269|PubMed:2019583, ECO:0000269|PubMed:8119939, ECO:0000269|PubMed:9639531}. |
| P00491 | PNP | S33 | ochoa | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) | Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964). {ECO:0000269|PubMed:23438750, ECO:0000269|PubMed:9305964}. |
| P00505 | GOT2 | S133 | ochoa | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
| P04049 | RAF1 | S227 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P06733 | ENO1 | S157 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07550 | ADRB2 | Y354 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P10275 | AR | S206 | ochoa | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P11172 | UMPS | S335 | psp | Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)] | Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP). {ECO:0000269|PubMed:18184586, ECO:0000269|PubMed:9042911}. |
| P11413 | G6PD | S160 | ochoa | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
| P13611 | VCAN | S2941 | ochoa | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
| P15056 | BRAF | S394 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P17097 | ZNF7 | S112 | ochoa | Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) | May be involved in transcriptional regulation. |
| P21333 | FLNA | S1835 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21399 | ACO1 | S711 | psp | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) | Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}. |
| P23327 | HRC | S457 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P25100 | ADRA1D | S300 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P30622 | CLIP1 | S200 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P32926 | DSG3 | S771 | ochoa | Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}. |
| P37059 | HSD17B2 | S218 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
| P38398 | BRCA1 | S1387 | psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42684 | ABL2 | S202 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46060 | RANGAP1 | S427 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P46937 | YAP1 | S366 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P48382 | RFX5 | S312 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P48634 | PRRC2A | S146 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48681 | NES | S47 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49755 | TMED10 | S86 | ochoa | Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) | Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (PubMed:10052452, PubMed:11726511, PubMed:16641999, PubMed:17288597, PubMed:19296914, PubMed:20427317, PubMed:21219331, PubMed:27569046). The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (PubMed:10052452). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side (PubMed:20427317, PubMed:27569046). Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:10052452, PubMed:10852829, PubMed:12237308). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (PubMed:20427317, PubMed:27569046). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment (PubMed:11726511). Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (PubMed:17288597). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation (PubMed:11726511). Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus (PubMed:19296914). Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization (PubMed:21219331). In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC (PubMed:32272059). Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 (PubMed:32272059). Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (PubMed:16641999). {ECO:0000250|UniProtKB:Q28735, ECO:0000250|UniProtKB:Q63584, ECO:0000269|PubMed:10052452, ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:16641999, ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331, ECO:0000269|PubMed:27569046, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:10052452}. |
| P51114 | FXR1 | S585 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P51911 | CNN1 | S175 | ochoa | Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}. |
| P51911 | CNN1 | S215 | ochoa | Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}. |
| P52948 | NUP98 | S709 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P78348 | ASIC1 | S499 | psp | Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) | Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). {ECO:0000250|UniProtKB:Q6NXK8, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:32915133, ECO:0000269|PubMed:34319232}.; FUNCTION: [Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium. {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster (PubMed:21036899). Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present (PubMed:21036899). Also potentially permeable to lithium and potassium (PubMed:21036899). {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro. {ECO:0000269|PubMed:21036899}. |
| P82094 | TMF1 | S319 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q07912 | TNK2 | S445 | psp | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q09666 | AHNAK | S1023 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12815 | TROAP | S404 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12955 | ANK3 | S531 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13021 | MALL | S66 | ochoa | MAL-like protein (Protein BENE) | None |
| Q13303 | KCNAB2 | S111 | ochoa | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}. |
| Q13496 | MTM1 | S23 | ochoa | Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:10900271, PubMed:11001925, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:23818870, ECO:0000269|PubMed:9537414}. |
| Q14493 | SLBP | S112 | ochoa | Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) | RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}. |
| Q14571 | ITPR2 | S1871 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| Q14680 | MELK | S363 | ochoa | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14722 | KCNAB1 | S163 | ochoa | Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels (PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988, PubMed:7649300, PubMed:7890764, PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:9763623}.; FUNCTION: [Isoform KvB1.2]: Isoform KvB1.2 shows no effect on KCNA1, KCNA2 or KCNB1. {ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764}. |
| Q15334 | LLGL1 | S961 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15417 | CNN3 | S215 | ochoa | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q15417 | CNN3 | S254 | ochoa | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q2KJY2 | KIF26B | S269 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M1P5 | KIF7 | S456 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q3V6T2 | CCDC88A | S1550 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q4KMQ2 | ANO6 | S156 | ochoa | Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F) | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts (PubMed:20056604, PubMed:21107324, PubMed:21908539, PubMed:22006324, PubMed:22946059). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q6P9J9, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:21908539, ECO:0000269|PubMed:22006324, ECO:0000269|PubMed:22946059}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. {ECO:0000269|PubMed:33827113}. |
| Q53EL6 | PDCD4 | S313 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5QJE6 | DNTTIP2 | S37 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5VT06 | CEP350 | S1245 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VV67 | PPRC1 | S1626 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q5VZF2 | MBNL2 | S56 | ochoa | Muscleblind-like protein 2 (Muscleblind-like protein 1) (Muscleblind-like protein-like) (Muscleblind-like protein-like 39) | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity). Regulates NCOR2 alternative splicing (By similarity). Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). {ECO:0000250|UniProtKB:F2Z3T4, ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16273094, ECO:0000269|PubMed:16946708}. |
| Q658Y4 | FAM91A1 | S332 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6DN90 | IQSEC1 | S358 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6NYC8 | PPP1R18 | S307 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P9A1 | ZNF530 | S130 | ochoa | Zinc finger protein 530 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6PJG2 | MIDEAS | S996 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6ZUM4 | ARHGAP27 | S182 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q7Z4S6 | KIF21A | S864 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6Z7 | HUWE1 | S2636 | ochoa|psp | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86T90 | KIAA1328 | S81 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86TC9 | MYPN | S1051 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86V81 | ALYREF | S94 | ochoa | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B (PubMed:17984224). Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex (PubMed:37020021). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:37020021). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224, PubMed:37020021). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) (PubMed:11675789, PubMed:11707413, PubMed:11979277, PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038). Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation (PubMed:10488337). Involved in transcription elongation and genome stability (PubMed:12438613). {ECO:0000269|PubMed:10488337, ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:11707413, ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:25662211, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:37020021}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. {ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:18974867}. |
| Q86X10 | RALGAPB | S724 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q8IU60 | DCP2 | S247 | ochoa | m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) | Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12218187, PubMed:12417715, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:28002401}. |
| Q8IZ07 | ANKRD13A | S510 | ochoa | Ankyrin repeat domain-containing protein 13A (Protein KE03) | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}. |
| Q8N1F7 | NUP93 | S75 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N1I0 | DOCK4 | S1750 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N4C6 | NIN | S152 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N5D0 | WDTC1 | S656 | ochoa | WD and tetratricopeptide repeats protein 1 | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16964240}. |
| Q8NDX5 | PHC3 | S228 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NDX5 | PHC3 | S229 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8TDN6 | BRIX1 | S247 | ochoa | Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2) | Required for biogenesis of the 60S ribosomal subunit. |
| Q92766 | RREB1 | S1642 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92844 | TANK | S211 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q969F2 | NKD2 | S31 | psp | Protein naked cuticle homolog 2 (Naked-2) (hNkd2) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. |
| Q96AG4 | LRRC59 | S23 | ochoa | Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}. |
| Q96IF1 | AJUBA | S263 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96KR1 | ZFR | S481 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96QD8 | SLC38A2 | S55 | ochoa | Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) | Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity). {ECO:0000250|UniProtKB:Q8CFE6, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15774260, ECO:0000269|PubMed:15922329, ECO:0000269|PubMed:16621798}. |
| Q96T17 | MAP7D2 | S702 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q96TA2 | YME1L1 | S704 | ochoa | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:24315374, PubMed:26923599, PubMed:27786171, PubMed:31695197, PubMed:33237841, PubMed:36206740). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975, PubMed:33237841). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461). Involved in the mitochondrial adaptation in response to various signals, such as stress or developmental cues, by mediating degradation of mitochondrial proteins to rewire the mitochondrial proteome (PubMed:31695197). Catalyzes degradation of mitochondrial proteins, such as translocases, lipid transfer proteins and metabolic enzymes in response to nutrient starvation in order to limit mitochondrial biogenesis: mechanistically, YME1L is activated by decreased phosphatidylethanolamine levels caused by LPIN1 activity in response to mTORC1 inhibition (PubMed:31695197). Acts as a regulator of adult neural stem cell self-renewal by promoting mitochondrial proteome rewiring, preserving neural stem and progenitor cells self-renewal (By similarity). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Mediates degradation of TIMM17A downstream of the integrated stress response (ISR) (PubMed:24315374). Catalyzes degradation of MICU1 when MICU1 is not assembled via an interchain disulfide (PubMed:36206740). {ECO:0000250|UniProtKB:O88967, ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461, ECO:0000269|PubMed:24315374, ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975, ECO:0000269|PubMed:27786171, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:33237841, ECO:0000269|PubMed:36206740}. |
| Q99439 | CNN2 | S217 | ochoa | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q99569 | PKP4 | S1121 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q9BR11 | ZSWIM1 | S44 | ochoa | Zinc finger SWIM domain-containing protein 1 | None |
| Q9BV35 | SLC25A23 | S417 | ochoa | Mitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23) | Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600). Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:24430870, ECO:0000269|PubMed:28695448}. |
| Q9BY77 | POLDIP3 | S42 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BZ29 | DOCK9 | S1221 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9BZE2 | PUS3 | S142 | ochoa | tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3) | Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. {ECO:0000269|PubMed:27055666}. |
| Q9C0C2 | TNKS1BP1 | S194 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H013 | ADAM19 | S756 | ochoa | Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM) | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}. |
| Q9H165 | BCL11A | S432 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H4G4 | GLIPR2 | S58 | ochoa | Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) | None |
| Q9H582 | ZNF644 | S669 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9HCD6 | TANC2 | S21 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCP0 | CSNK1G1 | S344 | psp | Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}. |
| Q9HCS7 | XAB2 | S751 | ochoa | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). {ECO:0000269|PubMed:10944529, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:17981804, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| Q9HD26 | GOPC | S407 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NPA3 | MID1IP1 | S75 | ochoa | Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499) (Spot 14-related protein) (S14R) (Spot 14-R) | Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). {ECO:0000250}. |
| Q9NQ75 | CASS4 | S232 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NR56 | MBNL1 | S56 | ochoa | Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). Regulates NCOR2 alternative splicing (By similarity). {ECO:0000250|UniProtKB:A0A8I6B1J2, ECO:0000269|PubMed:10970838, ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:37548402}. |
| Q9NTJ3 | SMC4 | S1030 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NV58 | RNF19A | S516 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9NYL2 | MAP3K20 | S568 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NYL9 | TMOD3 | S155 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9UBP0 | SPAST | S207 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
| Q9UKE5 | TNIK | S959 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UL54 | TAOK2 | S486 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULG1 | INO80 | S47 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9UMN6 | KMT2B | S1095 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UNS1 | TIMELESS | S281 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9Y244 | POMP | S22 | ochoa | Proteasome maturation protein (Proteassemblin) (Protein UMP1 homolog) (hUMP1) (Voltage-gated K channel beta subunit 4.1) | Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. {ECO:0000269|PubMed:15944226, ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17948026}. |
| Q9Y2U8 | LEMD3 | S149 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2X9 | ZNF281 | S799 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y3L3 | SH3BP1 | S243 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y3S1 | WNK2 | S1843 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y463 | DYRK1B | S421 | psp | Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). {ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035, ECO:0000269|PubMed:33469661}. |
| Q9Y478 | PRKAB1 | S96 | ochoa | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Q9Y490 | TLN1 | S814 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y6N7 | ROBO1 | S930 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| O14618 | CCS | S245 | Sugiyama | Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) | Delivers copper to copper zinc superoxide dismutase (SOD1). |
| P07900 | HSP90AA1 | S164 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S159 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q14568 | HSP90AA2P | S164 | Sugiyama | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q7LBC6 | KDM3B | S1259 | Sugiyama | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q9HCC0 | MCCC2 | S523 | Sugiyama | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) | Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}. |
| Q14160 | SCRIB | S493 | Sugiyama | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14028 | CNGB1 | S958 | Sugiyama | Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP) | Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:34699778). Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity) (PubMed:34699778). {ECO:0000250|UniProtKB:A0A8I5ZN27, ECO:0000250|UniProtKB:Q28181, ECO:0000250|UniProtKB:Q9NQW8, ECO:0000269|PubMed:34699778}.; FUNCTION: [Isoform GARP2]: High affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. {ECO:0000269|PubMed:16407240}. |
| P17844 | DDX5 | S557 | ELM | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| Q05586 | GRIN1 | S889 | ELM | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (hNR1) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (PubMed:26875626). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:27164704, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:38538865, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761, PubMed:36309015, PubMed:38598639). {ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:21376300, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27164704, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28228639, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:38598639, ECO:0000269|PubMed:7679115, ECO:0000269|PubMed:7681588, ECO:0000269|PubMed:7685113}. |
| P09769 | FGR | S418 | Sugiyama | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P47756 | CAPZB | S184 | Sugiyama | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| Q16658 | FSCN1 | S156 | Sugiyama | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| Q14524 | SCN5A | S524 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| P15880 | RPS2 | S225 | Sugiyama | Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250|UniProtKB:P25443, ECO:0000269|PubMed:23636399}. |
| Q8NBJ7 | SUMF2 | S264 | Sugiyama | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}. |
| Q04837 | SSBP1 | S79 | Sugiyama | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}. |
| Q15654 | TRIP6 | S400 | Sugiyama | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q92731 | ESR2 | S165 | GPS6 | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q10570 | CPSF1 | S712 | Sugiyama | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}. |
| Q92630 | DYRK2 | S482 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q15417 | CNN3 | S175 | Sugiyama | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q99439 | CNN2 | S177 | Sugiyama | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000001 | 5.886 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000007 | 5.138 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000010 | 5.006 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000016 | 4.798 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000090 | 4.048 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000174 | 3.761 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000212 | 3.674 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000344 | 3.464 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000635 | 3.197 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000789 | 3.103 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000872 | 3.059 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000872 | 3.059 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000912 | 3.040 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.001058 | 2.975 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.001161 | 2.935 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.001271 | 2.896 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.001262 | 2.899 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.001387 | 2.858 |
| R-HSA-2262752 | Cellular responses to stress | 0.001507 | 2.822 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.001642 | 2.785 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.001928 | 2.715 |
| R-HSA-68886 | M Phase | 0.002186 | 2.660 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.002083 | 2.681 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.002246 | 2.649 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.003066 | 2.513 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.003198 | 2.495 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.003375 | 2.472 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.003416 | 2.466 |
| R-HSA-9675108 | Nervous system development | 0.003575 | 2.447 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.003672 | 2.435 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.003790 | 2.421 |
| R-HSA-68875 | Mitotic Prophase | 0.004337 | 2.363 |
| R-HSA-3371556 | Cellular response to heat stress | 0.004494 | 2.347 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.004989 | 2.302 |
| R-HSA-422475 | Axon guidance | 0.005073 | 2.295 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.005835 | 2.234 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.005835 | 2.234 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.005835 | 2.234 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.005863 | 2.232 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.007009 | 2.154 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.007009 | 2.154 |
| R-HSA-390696 | Adrenoceptors | 0.007009 | 2.154 |
| R-HSA-191859 | snRNP Assembly | 0.007239 | 2.140 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.007239 | 2.140 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.007009 | 2.154 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.006901 | 2.161 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.008004 | 2.097 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.008004 | 2.097 |
| R-HSA-168255 | Influenza Infection | 0.007497 | 2.125 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.007417 | 2.130 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.008280 | 2.082 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.008280 | 2.082 |
| R-HSA-70171 | Glycolysis | 0.008782 | 2.056 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.009404 | 2.027 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.009647 | 2.016 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.009689 | 2.014 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.009689 | 2.014 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.009926 | 2.003 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.011094 | 1.955 |
| R-HSA-211000 | Gene Silencing by RNA | 0.011586 | 1.936 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.012657 | 1.898 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.013163 | 1.881 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.013826 | 1.859 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.014865 | 1.828 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.015462 | 1.811 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.015544 | 1.808 |
| R-HSA-70326 | Glucose metabolism | 0.016847 | 1.773 |
| R-HSA-8953854 | Metabolism of RNA | 0.016862 | 1.773 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.018338 | 1.737 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.018338 | 1.737 |
| R-HSA-68882 | Mitotic Anaphase | 0.018072 | 1.743 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.018445 | 1.734 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.019723 | 1.705 |
| R-HSA-1640170 | Cell Cycle | 0.018248 | 1.739 |
| R-HSA-6798695 | Neutrophil degranulation | 0.020054 | 1.698 |
| R-HSA-72306 | tRNA processing | 0.020755 | 1.683 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.021516 | 1.667 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.022231 | 1.653 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.022231 | 1.653 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.023574 | 1.628 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.023574 | 1.628 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.023574 | 1.628 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.023574 | 1.628 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.023815 | 1.623 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.028074 | 1.552 |
| R-HSA-72187 | mRNA 3'-end processing | 0.030815 | 1.511 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.033161 | 1.479 |
| R-HSA-68877 | Mitotic Prometaphase | 0.033632 | 1.473 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.035501 | 1.450 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.037583 | 1.425 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.037583 | 1.425 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.037583 | 1.425 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.043970 | 1.357 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.043970 | 1.357 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.043970 | 1.357 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.043970 | 1.357 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.043970 | 1.357 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.043970 | 1.357 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.043970 | 1.357 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.043970 | 1.357 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.043970 | 1.357 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.043970 | 1.357 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.043970 | 1.357 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.043970 | 1.357 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.040555 | 1.392 |
| R-HSA-200425 | Carnitine shuttle | 0.042735 | 1.369 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.039589 | 1.402 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.044055 | 1.356 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.045172 | 1.345 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.045404 | 1.343 |
| R-HSA-8941237 | Invadopodia formation | 0.054659 | 1.262 |
| R-HSA-9909438 | 3-Methylcrotonyl-CoA carboxylase deficiency | 0.054659 | 1.262 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.053765 | 1.270 |
| R-HSA-9620244 | Long-term potentiation | 0.048133 | 1.318 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.047466 | 1.324 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.052330 | 1.281 |
| R-HSA-373755 | Semaphorin interactions | 0.046761 | 1.330 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.045902 | 1.338 |
| R-HSA-162587 | HIV Life Cycle | 0.048758 | 1.312 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.056664 | 1.247 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.060447 | 1.219 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.061471 | 1.211 |
| R-HSA-162906 | HIV Infection | 0.061593 | 1.210 |
| R-HSA-162582 | Signal Transduction | 0.062196 | 1.206 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.064130 | 1.193 |
| R-HSA-9735763 | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | 0.065229 | 1.186 |
| R-HSA-9735786 | Nucleotide catabolism defects | 0.065229 | 1.186 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.086017 | 1.065 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.096238 | 1.017 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.096238 | 1.017 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 0.096238 | 1.017 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 0.096238 | 1.017 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.106346 | 0.973 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 0.106346 | 0.973 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.116341 | 0.934 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.116341 | 0.934 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.126225 | 0.899 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.126225 | 0.899 |
| R-HSA-2022923 | DS-GAG biosynthesis | 0.155221 | 0.809 |
| R-HSA-428540 | Activation of RAC1 | 0.155221 | 0.809 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.155221 | 0.809 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.155221 | 0.809 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.164673 | 0.783 |
| R-HSA-1663150 | The activation of arylsulfatases | 0.183261 | 0.737 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.201438 | 0.696 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.210375 | 0.677 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.210375 | 0.677 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.210375 | 0.677 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.210375 | 0.677 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.088352 | 1.054 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.219212 | 0.659 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.219212 | 0.659 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.219212 | 0.659 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.219212 | 0.659 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.236594 | 0.626 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.245139 | 0.611 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.245139 | 0.611 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.245139 | 0.611 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.245139 | 0.611 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.245139 | 0.611 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.253590 | 0.596 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.253590 | 0.596 |
| R-HSA-2022870 | CS-GAG biosynthesis | 0.261946 | 0.582 |
| R-HSA-72649 | Translation initiation complex formation | 0.154520 | 0.811 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.294452 | 0.531 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.090459 | 1.044 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.090459 | 1.044 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.162368 | 0.789 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.317893 | 0.498 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.325533 | 0.487 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.190346 | 0.720 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.190346 | 0.720 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.202529 | 0.694 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.214799 | 0.668 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.231260 | 0.636 |
| R-HSA-380287 | Centrosome maturation | 0.239523 | 0.621 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.251942 | 0.599 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.297514 | 0.526 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.309894 | 0.509 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.314011 | 0.503 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.219207 | 0.659 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.105753 | 0.976 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.302353 | 0.519 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.245139 | 0.611 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.305772 | 0.515 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.102202 | 0.991 |
| R-HSA-156902 | Peptide chain elongation | 0.297514 | 0.526 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.174019 | 0.759 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.155221 | 0.809 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.210375 | 0.677 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.264378 | 0.578 |
| R-HSA-72172 | mRNA Splicing | 0.245503 | 0.610 |
| R-HSA-5673000 | RAF activation | 0.078371 | 1.106 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.086017 | 1.065 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.102202 | 0.991 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.130424 | 0.885 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.183261 | 0.737 |
| R-HSA-9907900 | Proteasome assembly | 0.116601 | 0.933 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.135482 | 0.868 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.135999 | 0.866 |
| R-HSA-192905 | vRNP Assembly | 0.145664 | 0.837 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.164673 | 0.783 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.142896 | 0.845 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.317893 | 0.498 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.325533 | 0.487 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.120518 | 0.919 |
| R-HSA-170968 | Frs2-mediated activation | 0.174019 | 0.759 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.120518 | 0.919 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.253627 | 0.596 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.318123 | 0.497 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.283842 | 0.547 |
| R-HSA-3371511 | HSF1 activation | 0.084984 | 1.071 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.120277 | 0.920 |
| R-HSA-169893 | Prolonged ERK activation events | 0.201438 | 0.696 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.192400 | 0.716 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.126225 | 0.899 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 0.174019 | 0.759 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.146750 | 0.833 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.113282 | 0.946 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.276816 | 0.558 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.086913 | 1.061 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.227952 | 0.642 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.150211 | 0.823 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.105753 | 0.976 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.136923 | 0.864 |
| R-HSA-205025 | NADE modulates death signalling | 0.065229 | 1.186 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.086017 | 1.065 |
| R-HSA-170984 | ARMS-mediated activation | 0.126225 | 0.899 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.183261 | 0.737 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.078371 | 1.106 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.210375 | 0.677 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.227952 | 0.642 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.236594 | 0.626 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.123982 | 0.907 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.086151 | 1.065 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.170287 | 0.769 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.090459 | 1.044 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.147370 | 0.832 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.146750 | 0.833 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.286461 | 0.543 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.294452 | 0.531 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.195022 | 0.710 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.198458 | 0.702 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.090724 | 1.042 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.071932 | 1.143 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.219212 | 0.659 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.236594 | 0.626 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.286461 | 0.543 |
| R-HSA-5689603 | UCH proteinases | 0.243659 | 0.613 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.280960 | 0.551 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.116601 | 0.933 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.227952 | 0.642 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.073778 | 1.132 |
| R-HSA-389542 | NADPH regeneration | 0.096238 | 1.017 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.106346 | 0.973 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.192400 | 0.716 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 0.201438 | 0.696 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.084984 | 1.071 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.142896 | 0.845 |
| R-HSA-429947 | Deadenylation of mRNA | 0.286461 | 0.543 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.294452 | 0.531 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.121714 | 0.915 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.325533 | 0.487 |
| R-HSA-2028269 | Signaling by Hippo | 0.219212 | 0.659 |
| R-HSA-196780 | Biotin transport and metabolism | 0.192400 | 0.716 |
| R-HSA-397014 | Muscle contraction | 0.265051 | 0.577 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.151818 | 0.819 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.236594 | 0.626 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.116601 | 0.933 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.079859 | 1.098 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.130424 | 0.885 |
| R-HSA-112316 | Neuronal System | 0.312161 | 0.506 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.102371 | 0.990 |
| R-HSA-165159 | MTOR signalling | 0.109338 | 0.961 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.094855 | 1.023 |
| R-HSA-9613354 | Lipophagy | 0.126225 | 0.899 |
| R-HSA-8949664 | Processing of SMDT1 | 0.174019 | 0.759 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.192400 | 0.716 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 0.201438 | 0.696 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.201438 | 0.696 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.219212 | 0.659 |
| R-HSA-3371568 | Attenuation phase | 0.098685 | 1.006 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.174270 | 0.759 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.156359 | 0.806 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.231260 | 0.636 |
| R-HSA-9612973 | Autophagy | 0.311290 | 0.507 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.092646 | 1.033 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.192400 | 0.716 |
| R-HSA-69275 | G2/M Transition | 0.082969 | 1.081 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.169317 | 0.771 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.085611 | 1.067 |
| R-HSA-373752 | Netrin-1 signaling | 0.116601 | 0.933 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.073778 | 1.132 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.126225 | 0.899 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.126225 | 0.899 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.192400 | 0.716 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.227952 | 0.642 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.154520 | 0.811 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.294452 | 0.531 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.302353 | 0.519 |
| R-HSA-9609690 | HCMV Early Events | 0.223931 | 0.650 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.233458 | 0.632 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.204777 | 0.689 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.098665 | 1.006 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.227136 | 0.644 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.115675 | 0.937 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.294452 | 0.531 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.294452 | 0.531 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.299895 | 0.523 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.183261 | 0.737 |
| R-HSA-392517 | Rap1 signalling | 0.236594 | 0.626 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.261946 | 0.582 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.162368 | 0.789 |
| R-HSA-983189 | Kinesins | 0.178269 | 0.749 |
| R-HSA-622312 | Inflammasomes | 0.317893 | 0.498 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.317893 | 0.498 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.317893 | 0.498 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.325533 | 0.487 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.069238 | 1.160 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.189356 | 0.723 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.200731 | 0.697 |
| R-HSA-193144 | Estrogen biosynthesis | 0.164673 | 0.783 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.201438 | 0.696 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.270210 | 0.568 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.302353 | 0.519 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.325533 | 0.487 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.135482 | 0.868 |
| R-HSA-4086400 | PCP/CE pathway | 0.251942 | 0.599 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.318123 | 0.497 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.173675 | 0.760 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.201438 | 0.696 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.253590 | 0.596 |
| R-HSA-3214842 | HDMs demethylate histones | 0.294452 | 0.531 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.305178 | 0.515 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.289090 | 0.539 |
| R-HSA-8876725 | Protein methylation | 0.192400 | 0.716 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 0.253590 | 0.596 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.194396 | 0.711 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.247639 | 0.606 |
| R-HSA-9610379 | HCMV Late Events | 0.135970 | 0.867 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.116341 | 0.934 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.135999 | 0.866 |
| R-HSA-9842663 | Signaling by LTK | 0.164673 | 0.783 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.192400 | 0.716 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.261946 | 0.582 |
| R-HSA-983712 | Ion channel transport | 0.207521 | 0.683 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.247639 | 0.606 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.302353 | 0.519 |
| R-HSA-5688426 | Deubiquitination | 0.198895 | 0.701 |
| R-HSA-8978934 | Metabolism of cofactors | 0.223018 | 0.652 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.201438 | 0.696 |
| R-HSA-9755088 | Ribavirin ADME | 0.261946 | 0.582 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.280960 | 0.551 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.270210 | 0.568 |
| R-HSA-8983711 | OAS antiviral response | 0.164673 | 0.783 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.294452 | 0.531 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.224788 | 0.648 |
| R-HSA-74160 | Gene expression (Transcription) | 0.235249 | 0.628 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.183030 | 0.737 |
| R-HSA-9663891 | Selective autophagy | 0.297514 | 0.526 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.323524 | 0.490 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.124230 | 0.906 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.174019 | 0.759 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.219212 | 0.659 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.127921 | 0.893 |
| R-HSA-913531 | Interferon Signaling | 0.303075 | 0.518 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.183261 | 0.737 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.236594 | 0.626 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.325533 | 0.487 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.195022 | 0.710 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.183511 | 0.736 |
| R-HSA-9679506 | SARS-CoV Infections | 0.116498 | 0.934 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.289243 | 0.539 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.214511 | 0.669 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.256629 | 0.591 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.314011 | 0.503 |
| R-HSA-73887 | Death Receptor Signaling | 0.305178 | 0.515 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.171244 | 0.766 |
| R-HSA-5619102 | SLC transporter disorders | 0.156484 | 0.806 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.095203 | 1.021 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.146750 | 0.833 |
| R-HSA-449147 | Signaling by Interleukins | 0.303457 | 0.518 |
| R-HSA-8939211 | ESR-mediated signaling | 0.327647 | 0.485 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.330423 | 0.481 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.333089 | 0.477 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.333089 | 0.477 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.333089 | 0.477 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.333089 | 0.477 |
| R-HSA-168256 | Immune System | 0.333225 | 0.477 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.334510 | 0.476 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.334510 | 0.476 |
| R-HSA-597592 | Post-translational protein modification | 0.337244 | 0.472 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.338590 | 0.470 |
| R-HSA-1296071 | Potassium Channels | 0.338590 | 0.470 |
| R-HSA-199991 | Membrane Trafficking | 0.339296 | 0.469 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.340560 | 0.468 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.340560 | 0.468 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.340560 | 0.468 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.342662 | 0.465 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.346727 | 0.460 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.347947 | 0.458 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.347947 | 0.458 |
| R-HSA-354192 | Integrin signaling | 0.355253 | 0.449 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.355253 | 0.449 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.355253 | 0.449 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.355253 | 0.449 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.355253 | 0.449 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.355253 | 0.449 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.355253 | 0.449 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.355253 | 0.449 |
| R-HSA-4839726 | Chromatin organization | 0.358094 | 0.446 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.358870 | 0.445 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.358870 | 0.445 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.360194 | 0.443 |
| R-HSA-9609646 | HCMV Infection | 0.360634 | 0.443 |
| R-HSA-390522 | Striated Muscle Contraction | 0.362477 | 0.441 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.362477 | 0.441 |
| R-HSA-2024101 | CS/DS degradation | 0.362477 | 0.441 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.362477 | 0.441 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.362477 | 0.441 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.362477 | 0.441 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.362477 | 0.441 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.362477 | 0.441 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.362477 | 0.441 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.362477 | 0.441 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.366286 | 0.436 |
| R-HSA-192823 | Viral mRNA Translation | 0.366920 | 0.435 |
| R-HSA-1266738 | Developmental Biology | 0.367434 | 0.435 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.369621 | 0.432 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.369621 | 0.432 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.369621 | 0.432 |
| R-HSA-203615 | eNOS activation | 0.369621 | 0.432 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.369621 | 0.432 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.369621 | 0.432 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.369621 | 0.432 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.369621 | 0.432 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.370930 | 0.431 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.370930 | 0.431 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.372368 | 0.429 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.375863 | 0.425 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.376685 | 0.424 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.376685 | 0.424 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.376685 | 0.424 |
| R-HSA-187687 | Signalling to ERKs | 0.376685 | 0.424 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.376685 | 0.424 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.376685 | 0.424 |
| R-HSA-169911 | Regulation of Apoptosis | 0.376685 | 0.424 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.376685 | 0.424 |
| R-HSA-381042 | PERK regulates gene expression | 0.376685 | 0.424 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.376685 | 0.424 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.378921 | 0.421 |
| R-HSA-418346 | Platelet homeostasis | 0.382901 | 0.417 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.382901 | 0.417 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.383670 | 0.416 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.383670 | 0.416 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.386870 | 0.412 |
| R-HSA-2559583 | Cellular Senescence | 0.387525 | 0.412 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.390577 | 0.408 |
| R-HSA-4641258 | Degradation of DVL | 0.390577 | 0.408 |
| R-HSA-4641257 | Degradation of AXIN | 0.390577 | 0.408 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.390577 | 0.408 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.390827 | 0.408 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.390827 | 0.408 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.390827 | 0.408 |
| R-HSA-416476 | G alpha (q) signalling events | 0.396120 | 0.402 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.397408 | 0.401 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.397408 | 0.401 |
| R-HSA-74217 | Purine salvage | 0.397408 | 0.401 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.397408 | 0.401 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.404162 | 0.393 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.404162 | 0.393 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.404162 | 0.393 |
| R-HSA-69541 | Stabilization of p53 | 0.404162 | 0.393 |
| R-HSA-71336 | Pentose phosphate pathway | 0.404162 | 0.393 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.406543 | 0.391 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.406543 | 0.391 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.410841 | 0.386 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.410841 | 0.386 |
| R-HSA-9646399 | Aggrephagy | 0.410841 | 0.386 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.410841 | 0.386 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.410841 | 0.386 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.414328 | 0.383 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.414328 | 0.383 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.417445 | 0.379 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.417445 | 0.379 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.417445 | 0.379 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.417445 | 0.379 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.417445 | 0.379 |
| R-HSA-9607240 | FLT3 Signaling | 0.417445 | 0.379 |
| R-HSA-5617833 | Cilium Assembly | 0.417561 | 0.379 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.418202 | 0.379 |
| R-HSA-109582 | Hemostasis | 0.419094 | 0.378 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.421295 | 0.375 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.422063 | 0.375 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.423976 | 0.373 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.423976 | 0.373 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.423976 | 0.373 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.423976 | 0.373 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.425911 | 0.371 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.429745 | 0.367 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.429745 | 0.367 |
| R-HSA-373760 | L1CAM interactions | 0.429745 | 0.367 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.430434 | 0.366 |
| R-HSA-446728 | Cell junction organization | 0.431300 | 0.365 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.435359 | 0.361 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.436821 | 0.360 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.436821 | 0.360 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.436821 | 0.360 |
| R-HSA-5693538 | Homology Directed Repair | 0.437373 | 0.359 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.441260 | 0.355 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.443135 | 0.353 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.443135 | 0.353 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.449380 | 0.347 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.449380 | 0.347 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.449380 | 0.347 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.449380 | 0.347 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.449380 | 0.347 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.449380 | 0.347 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.449380 | 0.347 |
| R-HSA-9824272 | Somitogenesis | 0.449380 | 0.347 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.449380 | 0.347 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.449380 | 0.347 |
| R-HSA-168249 | Innate Immune System | 0.450481 | 0.346 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.452954 | 0.344 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.455510 | 0.342 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.455555 | 0.341 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.455555 | 0.341 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.455555 | 0.341 |
| R-HSA-9675135 | Diseases of DNA repair | 0.455555 | 0.341 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.455555 | 0.341 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.455555 | 0.341 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.455555 | 0.341 |
| R-HSA-75153 | Apoptotic execution phase | 0.455555 | 0.341 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.459922 | 0.337 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.461661 | 0.336 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.461661 | 0.336 |
| R-HSA-5357801 | Programmed Cell Death | 0.464561 | 0.333 |
| R-HSA-194138 | Signaling by VEGF | 0.467322 | 0.330 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.467322 | 0.330 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.467322 | 0.330 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.467322 | 0.330 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.467698 | 0.330 |
| R-HSA-70263 | Gluconeogenesis | 0.467698 | 0.330 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.471000 | 0.327 |
| R-HSA-9766229 | Degradation of CDH1 | 0.473669 | 0.325 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.473669 | 0.325 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.473669 | 0.325 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.473669 | 0.325 |
| R-HSA-69481 | G2/M Checkpoints | 0.474662 | 0.324 |
| R-HSA-114608 | Platelet degranulation | 0.474662 | 0.324 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.479573 | 0.319 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.484610 | 0.315 |
| R-HSA-912446 | Meiotic recombination | 0.485411 | 0.314 |
| R-HSA-2514856 | The phototransduction cascade | 0.485411 | 0.314 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.485411 | 0.314 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.485411 | 0.314 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.485411 | 0.314 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.491184 | 0.309 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.491184 | 0.309 |
| R-HSA-5576891 | Cardiac conduction | 0.492743 | 0.307 |
| R-HSA-1221632 | Meiotic synapsis | 0.496892 | 0.304 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.496892 | 0.304 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.496892 | 0.304 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.496892 | 0.304 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.496892 | 0.304 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.496892 | 0.304 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.499866 | 0.301 |
| R-HSA-418990 | Adherens junctions interactions | 0.501509 | 0.300 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.502537 | 0.299 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.508119 | 0.294 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.508119 | 0.294 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.508119 | 0.294 |
| R-HSA-8951664 | Neddylation | 0.509853 | 0.293 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.513638 | 0.289 |
| R-HSA-5578775 | Ion homeostasis | 0.513638 | 0.289 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.513638 | 0.289 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.513638 | 0.289 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.513638 | 0.289 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.517391 | 0.286 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.519096 | 0.285 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.519096 | 0.285 |
| R-HSA-1500931 | Cell-Cell communication | 0.523418 | 0.281 |
| R-HSA-6807070 | PTEN Regulation | 0.524287 | 0.280 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.524493 | 0.280 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.524493 | 0.280 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.529830 | 0.276 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.529830 | 0.276 |
| R-HSA-1632852 | Macroautophagy | 0.531117 | 0.275 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.531117 | 0.275 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.535107 | 0.272 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.535107 | 0.272 |
| R-HSA-351202 | Metabolism of polyamines | 0.535107 | 0.272 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.539639 | 0.268 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.540325 | 0.267 |
| R-HSA-8956321 | Nucleotide salvage | 0.540325 | 0.267 |
| R-HSA-112043 | PLC beta mediated events | 0.540325 | 0.267 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.540325 | 0.267 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.545147 | 0.263 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.545485 | 0.263 |
| R-HSA-1268020 | Mitochondrial protein import | 0.545485 | 0.263 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.545485 | 0.263 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.550588 | 0.259 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.550588 | 0.259 |
| R-HSA-9758941 | Gastrulation | 0.561022 | 0.251 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.562064 | 0.250 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.564261 | 0.249 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.564261 | 0.249 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.565556 | 0.248 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.565556 | 0.248 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.570434 | 0.244 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.570434 | 0.244 |
| R-HSA-112040 | G-protein mediated events | 0.570434 | 0.244 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.570434 | 0.244 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.570434 | 0.244 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.570686 | 0.244 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.573873 | 0.241 |
| R-HSA-69306 | DNA Replication | 0.573873 | 0.241 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.575258 | 0.240 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.575258 | 0.240 |
| R-HSA-5218859 | Regulated Necrosis | 0.575258 | 0.240 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.582214 | 0.235 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.584745 | 0.233 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.584745 | 0.233 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.584745 | 0.233 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.584745 | 0.233 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.584745 | 0.233 |
| R-HSA-421270 | Cell-cell junction organization | 0.589013 | 0.230 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.589409 | 0.230 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.589409 | 0.230 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.589409 | 0.230 |
| R-HSA-3000178 | ECM proteoglycans | 0.589409 | 0.230 |
| R-HSA-9711097 | Cellular response to starvation | 0.589550 | 0.229 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.589550 | 0.229 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.594020 | 0.226 |
| R-HSA-74259 | Purine catabolism | 0.594020 | 0.226 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.594020 | 0.226 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.598581 | 0.223 |
| R-HSA-4086398 | Ca2+ pathway | 0.598581 | 0.223 |
| R-HSA-109581 | Apoptosis | 0.601783 | 0.221 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.603090 | 0.220 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.603090 | 0.220 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.603090 | 0.220 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.607549 | 0.216 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.607549 | 0.216 |
| R-HSA-917937 | Iron uptake and transport | 0.607549 | 0.216 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.607549 | 0.216 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.607796 | 0.216 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.618310 | 0.209 |
| R-HSA-73894 | DNA Repair | 0.620411 | 0.207 |
| R-HSA-5619084 | ABC transporter disorders | 0.620630 | 0.207 |
| R-HSA-9659379 | Sensory processing of sound | 0.624893 | 0.204 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.626562 | 0.203 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.628301 | 0.202 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.628599 | 0.202 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.629108 | 0.201 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.629108 | 0.201 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.636832 | 0.196 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.636832 | 0.196 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.636832 | 0.196 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.636832 | 0.196 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.641474 | 0.193 |
| R-HSA-9824446 | Viral Infection Pathways | 0.644287 | 0.191 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.645504 | 0.190 |
| R-HSA-1500620 | Meiosis | 0.649489 | 0.187 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.657326 | 0.182 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.657326 | 0.182 |
| R-HSA-9658195 | Leishmania infection | 0.659559 | 0.181 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.659559 | 0.181 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.667836 | 0.175 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.668756 | 0.175 |
| R-HSA-202424 | Downstream TCR signaling | 0.672481 | 0.172 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.672481 | 0.172 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.677207 | 0.169 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.683408 | 0.165 |
| R-HSA-2029481 | FCGR activation | 0.686969 | 0.163 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.686969 | 0.163 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.686969 | 0.163 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.689370 | 0.162 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.690490 | 0.161 |
| R-HSA-195721 | Signaling by WNT | 0.695499 | 0.158 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.697415 | 0.157 |
| R-HSA-422356 | Regulation of insulin secretion | 0.707515 | 0.150 |
| R-HSA-190236 | Signaling by FGFR | 0.707515 | 0.150 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.713873 | 0.146 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.714061 | 0.146 |
| R-HSA-392499 | Metabolism of proteins | 0.714965 | 0.146 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.717279 | 0.144 |
| R-HSA-1483255 | PI Metabolism | 0.720461 | 0.142 |
| R-HSA-6805567 | Keratinization | 0.723045 | 0.141 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.726719 | 0.139 |
| R-HSA-111885 | Opioid Signalling | 0.726719 | 0.139 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.729795 | 0.137 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.729795 | 0.137 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.732837 | 0.135 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.738503 | 0.132 |
| R-HSA-69239 | Synthesis of DNA | 0.738820 | 0.131 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.738820 | 0.131 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.738820 | 0.131 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.741760 | 0.130 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.743067 | 0.129 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.744669 | 0.128 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.747544 | 0.126 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.747544 | 0.126 |
| R-HSA-202403 | TCR signaling | 0.747544 | 0.126 |
| R-HSA-1280218 | Adaptive Immune System | 0.765994 | 0.116 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.766790 | 0.115 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.766790 | 0.115 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.773016 | 0.112 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.774585 | 0.111 |
| R-HSA-72312 | rRNA processing | 0.776805 | 0.110 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.782121 | 0.107 |
| R-HSA-212436 | Generic Transcription Pathway | 0.783543 | 0.106 |
| R-HSA-15869 | Metabolism of nucleotides | 0.784219 | 0.106 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.787005 | 0.104 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.787005 | 0.104 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.787005 | 0.104 |
| R-HSA-69206 | G1/S Transition | 0.794128 | 0.100 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.801014 | 0.096 |
| R-HSA-8956319 | Nucleotide catabolism | 0.803258 | 0.095 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.805477 | 0.094 |
| R-HSA-1474165 | Reproduction | 0.807671 | 0.093 |
| R-HSA-9909396 | Circadian clock | 0.811985 | 0.090 |
| R-HSA-163685 | Integration of energy metabolism | 0.822354 | 0.085 |
| R-HSA-9664407 | Parasite infection | 0.830239 | 0.081 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.830239 | 0.081 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.830239 | 0.081 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.837775 | 0.077 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.839606 | 0.076 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.842988 | 0.074 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.843208 | 0.074 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.843605 | 0.074 |
| R-HSA-2187338 | Visual phototransduction | 0.844978 | 0.073 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.846729 | 0.072 |
| R-HSA-69242 | S Phase | 0.846729 | 0.072 |
| R-HSA-166520 | Signaling by NTRKs | 0.846729 | 0.072 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.847660 | 0.072 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.848402 | 0.071 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.849900 | 0.071 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.850171 | 0.070 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.853537 | 0.069 |
| R-HSA-9609507 | Protein localization | 0.855191 | 0.068 |
| R-HSA-877300 | Interferon gamma signaling | 0.864735 | 0.063 |
| R-HSA-1483257 | Phospholipid metabolism | 0.870908 | 0.060 |
| R-HSA-5663205 | Infectious disease | 0.876259 | 0.057 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.877118 | 0.057 |
| R-HSA-382551 | Transport of small molecules | 0.880884 | 0.055 |
| R-HSA-5668914 | Diseases of metabolism | 0.881816 | 0.055 |
| R-HSA-418555 | G alpha (s) signalling events | 0.883321 | 0.054 |
| R-HSA-72766 | Translation | 0.883650 | 0.054 |
| R-HSA-388396 | GPCR downstream signalling | 0.886509 | 0.052 |
| R-HSA-611105 | Respiratory electron transport | 0.892252 | 0.050 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.898213 | 0.047 |
| R-HSA-3781865 | Diseases of glycosylation | 0.899365 | 0.046 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.901630 | 0.045 |
| R-HSA-1643685 | Disease | 0.902577 | 0.045 |
| R-HSA-1474244 | Extracellular matrix organization | 0.906787 | 0.042 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.907074 | 0.042 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.909167 | 0.041 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.914968 | 0.039 |
| R-HSA-428157 | Sphingolipid metabolism | 0.917080 | 0.038 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.918949 | 0.037 |
| R-HSA-9748784 | Drug ADME | 0.932466 | 0.030 |
| R-HSA-372790 | Signaling by GPCR | 0.933171 | 0.030 |
| R-HSA-157118 | Signaling by NOTCH | 0.947466 | 0.023 |
| R-HSA-418594 | G alpha (i) signalling events | 0.954671 | 0.020 |
| R-HSA-8978868 | Fatty acid metabolism | 0.954671 | 0.020 |
| R-HSA-500792 | GPCR ligand binding | 0.969248 | 0.014 |
| R-HSA-8957322 | Metabolism of steroids | 0.979930 | 0.009 |
| R-HSA-211859 | Biological oxidations | 0.985426 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.991438 | 0.004 |
| R-HSA-1430728 | Metabolism | 0.999049 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999552 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999946 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999965 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.879 | 0.159 | 2 | 0.901 |
CDC7 |
0.875 | 0.133 | 1 | 0.826 |
GCN2 |
0.871 | 0.112 | 2 | 0.842 |
PIM3 |
0.867 | 0.096 | -3 | 0.833 |
ERK5 |
0.866 | 0.130 | 1 | 0.806 |
MTOR |
0.866 | 0.044 | 1 | 0.735 |
MOS |
0.865 | 0.110 | 1 | 0.835 |
NDR2 |
0.864 | 0.092 | -3 | 0.846 |
PRPK |
0.864 | -0.042 | -1 | 0.843 |
ULK2 |
0.863 | 0.040 | 2 | 0.819 |
NEK6 |
0.863 | 0.136 | -2 | 0.913 |
PRKD1 |
0.863 | 0.113 | -3 | 0.842 |
RAF1 |
0.862 | -0.008 | 1 | 0.780 |
ATR |
0.862 | 0.067 | 1 | 0.825 |
NLK |
0.861 | 0.073 | 1 | 0.760 |
CAMK1B |
0.861 | 0.032 | -3 | 0.869 |
PDHK4 |
0.861 | -0.129 | 1 | 0.787 |
DSTYK |
0.860 | 0.022 | 2 | 0.935 |
CLK3 |
0.860 | 0.085 | 1 | 0.791 |
CDKL5 |
0.860 | 0.085 | -3 | 0.786 |
MST4 |
0.859 | 0.119 | 2 | 0.881 |
MARK4 |
0.859 | 0.057 | 4 | 0.898 |
NUAK2 |
0.859 | 0.056 | -3 | 0.847 |
CDKL1 |
0.858 | 0.033 | -3 | 0.792 |
PRKD2 |
0.858 | 0.095 | -3 | 0.781 |
IKKB |
0.857 | -0.056 | -2 | 0.821 |
BMPR2 |
0.857 | -0.025 | -2 | 0.940 |
RSK2 |
0.857 | 0.071 | -3 | 0.763 |
NDR1 |
0.857 | 0.049 | -3 | 0.844 |
HUNK |
0.856 | -0.007 | 2 | 0.831 |
TBK1 |
0.856 | -0.078 | 1 | 0.651 |
NEK7 |
0.856 | 0.015 | -3 | 0.860 |
PKN3 |
0.856 | 0.042 | -3 | 0.841 |
WNK1 |
0.856 | 0.046 | -2 | 0.922 |
PDHK1 |
0.856 | -0.116 | 1 | 0.759 |
NIK |
0.856 | 0.056 | -3 | 0.900 |
SKMLCK |
0.856 | 0.082 | -2 | 0.901 |
HIPK4 |
0.855 | 0.063 | 1 | 0.736 |
CAMK2G |
0.854 | -0.062 | 2 | 0.829 |
PIM1 |
0.854 | 0.080 | -3 | 0.777 |
PKN2 |
0.854 | 0.063 | -3 | 0.861 |
MAPKAPK3 |
0.854 | 0.055 | -3 | 0.787 |
RIPK3 |
0.854 | -0.045 | 3 | 0.587 |
AMPKA1 |
0.854 | 0.051 | -3 | 0.872 |
DAPK2 |
0.853 | 0.064 | -3 | 0.878 |
TGFBR2 |
0.853 | 0.034 | -2 | 0.832 |
IKKE |
0.853 | -0.106 | 1 | 0.641 |
MLK1 |
0.853 | 0.012 | 2 | 0.876 |
CAMK2D |
0.852 | 0.038 | -3 | 0.861 |
NEK9 |
0.852 | 0.056 | 2 | 0.883 |
CAMLCK |
0.852 | 0.026 | -2 | 0.917 |
PKCD |
0.852 | 0.097 | 2 | 0.856 |
LATS2 |
0.852 | 0.060 | -5 | 0.823 |
P90RSK |
0.852 | 0.028 | -3 | 0.770 |
RSK3 |
0.852 | 0.037 | -3 | 0.760 |
AMPKA2 |
0.851 | 0.054 | -3 | 0.835 |
BCKDK |
0.850 | -0.074 | -1 | 0.800 |
NIM1 |
0.850 | 0.007 | 3 | 0.632 |
AURC |
0.850 | 0.119 | -2 | 0.718 |
CHAK2 |
0.850 | -0.011 | -1 | 0.782 |
MLK2 |
0.850 | 0.085 | 2 | 0.867 |
GRK5 |
0.850 | -0.061 | -3 | 0.872 |
MASTL |
0.849 | -0.081 | -2 | 0.893 |
ICK |
0.848 | 0.044 | -3 | 0.836 |
CDK8 |
0.848 | 0.031 | 1 | 0.601 |
TSSK1 |
0.847 | 0.051 | -3 | 0.888 |
IRE1 |
0.847 | 0.000 | 1 | 0.774 |
PKCB |
0.847 | 0.111 | 2 | 0.830 |
TSSK2 |
0.847 | 0.019 | -5 | 0.873 |
SRPK1 |
0.847 | 0.006 | -3 | 0.739 |
MNK2 |
0.847 | 0.102 | -2 | 0.863 |
ULK1 |
0.847 | -0.099 | -3 | 0.851 |
MAPKAPK2 |
0.847 | 0.045 | -3 | 0.727 |
P70S6KB |
0.847 | 0.021 | -3 | 0.797 |
WNK3 |
0.846 | -0.146 | 1 | 0.763 |
DYRK2 |
0.846 | 0.067 | 1 | 0.638 |
MLK3 |
0.846 | 0.062 | 2 | 0.830 |
PKR |
0.846 | 0.161 | 1 | 0.799 |
PKACG |
0.846 | 0.038 | -2 | 0.801 |
CDK19 |
0.845 | 0.035 | 1 | 0.564 |
QSK |
0.845 | 0.040 | 4 | 0.877 |
PKCA |
0.845 | 0.120 | 2 | 0.818 |
PKCG |
0.845 | 0.089 | 2 | 0.828 |
ATM |
0.844 | 0.018 | 1 | 0.777 |
QIK |
0.844 | -0.009 | -3 | 0.855 |
MELK |
0.844 | 0.013 | -3 | 0.823 |
FAM20C |
0.844 | 0.014 | 2 | 0.593 |
CDK7 |
0.843 | 0.013 | 1 | 0.620 |
KIS |
0.843 | -0.009 | 1 | 0.631 |
GRK6 |
0.843 | -0.052 | 1 | 0.796 |
CDK18 |
0.843 | 0.061 | 1 | 0.558 |
ANKRD3 |
0.842 | -0.053 | 1 | 0.802 |
PKCZ |
0.842 | 0.077 | 2 | 0.856 |
BMPR1B |
0.842 | 0.108 | 1 | 0.810 |
NEK2 |
0.842 | 0.053 | 2 | 0.878 |
TGFBR1 |
0.842 | 0.082 | -2 | 0.807 |
PAK1 |
0.842 | 0.037 | -2 | 0.847 |
CAMK2B |
0.842 | 0.034 | 2 | 0.787 |
LATS1 |
0.842 | 0.077 | -3 | 0.849 |
CDK5 |
0.842 | 0.047 | 1 | 0.646 |
CAMK4 |
0.842 | -0.038 | -3 | 0.837 |
RIPK1 |
0.841 | -0.126 | 1 | 0.773 |
PAK3 |
0.841 | 0.000 | -2 | 0.852 |
P38A |
0.841 | 0.062 | 1 | 0.668 |
PAK6 |
0.841 | 0.096 | -2 | 0.796 |
IKKA |
0.841 | -0.044 | -2 | 0.798 |
MNK1 |
0.841 | 0.086 | -2 | 0.872 |
PRKD3 |
0.840 | 0.019 | -3 | 0.747 |
DNAPK |
0.840 | 0.056 | 1 | 0.693 |
NUAK1 |
0.840 | -0.019 | -3 | 0.793 |
SMG1 |
0.840 | 0.019 | 1 | 0.787 |
DLK |
0.840 | -0.112 | 1 | 0.783 |
PLK1 |
0.840 | 0.012 | -2 | 0.883 |
SIK |
0.840 | 0.012 | -3 | 0.768 |
MARK3 |
0.839 | 0.035 | 4 | 0.838 |
PRP4 |
0.839 | 0.167 | -3 | 0.906 |
IRE2 |
0.839 | -0.039 | 2 | 0.795 |
YSK4 |
0.839 | 0.006 | 1 | 0.718 |
GRK1 |
0.839 | 0.010 | -2 | 0.796 |
PKCH |
0.838 | 0.056 | 2 | 0.806 |
AURB |
0.838 | 0.073 | -2 | 0.722 |
CAMK2A |
0.838 | 0.015 | 2 | 0.820 |
ALK4 |
0.838 | 0.012 | -2 | 0.845 |
BRSK1 |
0.838 | -0.015 | -3 | 0.801 |
MSK2 |
0.838 | -0.018 | -3 | 0.732 |
PHKG1 |
0.838 | 0.008 | -3 | 0.843 |
CDK13 |
0.838 | -0.005 | 1 | 0.588 |
MARK2 |
0.838 | 0.021 | 4 | 0.809 |
TTBK2 |
0.838 | -0.100 | 2 | 0.767 |
SRPK2 |
0.837 | -0.011 | -3 | 0.653 |
DRAK1 |
0.837 | 0.056 | 1 | 0.785 |
PIM2 |
0.836 | 0.055 | -3 | 0.743 |
PKACB |
0.836 | 0.074 | -2 | 0.734 |
MEK1 |
0.836 | -0.060 | 2 | 0.854 |
CDK2 |
0.836 | -0.001 | 1 | 0.660 |
RSK4 |
0.835 | 0.042 | -3 | 0.727 |
VRK2 |
0.835 | -0.043 | 1 | 0.811 |
ACVR2A |
0.835 | 0.052 | -2 | 0.836 |
MYLK4 |
0.835 | 0.013 | -2 | 0.831 |
SGK3 |
0.835 | 0.062 | -3 | 0.775 |
BRSK2 |
0.835 | -0.037 | -3 | 0.838 |
PERK |
0.835 | 0.086 | -2 | 0.892 |
CLK4 |
0.835 | 0.029 | -3 | 0.765 |
CHK1 |
0.835 | 0.012 | -3 | 0.835 |
CDK9 |
0.835 | -0.000 | 1 | 0.595 |
SRPK3 |
0.834 | -0.028 | -3 | 0.703 |
CDK1 |
0.834 | 0.010 | 1 | 0.582 |
P38B |
0.834 | 0.043 | 1 | 0.592 |
GRK4 |
0.834 | -0.136 | -2 | 0.851 |
PKG2 |
0.834 | 0.053 | -2 | 0.736 |
MLK4 |
0.833 | -0.008 | 2 | 0.802 |
MARK1 |
0.833 | -0.004 | 4 | 0.860 |
JNK2 |
0.833 | 0.045 | 1 | 0.551 |
ACVR2B |
0.833 | 0.045 | -2 | 0.838 |
CLK1 |
0.833 | 0.029 | -3 | 0.748 |
ERK1 |
0.833 | 0.028 | 1 | 0.578 |
CDK12 |
0.833 | 0.007 | 1 | 0.557 |
CDK17 |
0.833 | 0.021 | 1 | 0.501 |
CHAK1 |
0.833 | -0.078 | 2 | 0.820 |
PAK2 |
0.833 | -0.025 | -2 | 0.842 |
MSK1 |
0.832 | 0.014 | -3 | 0.742 |
P38G |
0.832 | 0.042 | 1 | 0.493 |
AURA |
0.832 | 0.062 | -2 | 0.690 |
HIPK1 |
0.832 | 0.051 | 1 | 0.655 |
TLK2 |
0.831 | 0.002 | 1 | 0.759 |
AKT2 |
0.831 | 0.038 | -3 | 0.678 |
HRI |
0.831 | -0.036 | -2 | 0.916 |
ERK7 |
0.831 | 0.158 | 2 | 0.691 |
JNK3 |
0.831 | 0.016 | 1 | 0.590 |
SNRK |
0.830 | -0.128 | 2 | 0.717 |
MST3 |
0.830 | 0.111 | 2 | 0.903 |
ALK2 |
0.830 | -0.005 | -2 | 0.818 |
NEK5 |
0.830 | 0.057 | 1 | 0.800 |
CDK3 |
0.830 | 0.036 | 1 | 0.522 |
CAMK1G |
0.830 | -0.029 | -3 | 0.758 |
PLK3 |
0.830 | -0.069 | 2 | 0.794 |
CDK14 |
0.829 | 0.038 | 1 | 0.591 |
MEKK1 |
0.829 | -0.013 | 1 | 0.743 |
MPSK1 |
0.829 | 0.142 | 1 | 0.783 |
DCAMKL1 |
0.829 | 0.023 | -3 | 0.798 |
WNK4 |
0.829 | -0.026 | -2 | 0.919 |
HIPK2 |
0.829 | 0.045 | 1 | 0.554 |
CDK16 |
0.828 | 0.051 | 1 | 0.518 |
CLK2 |
0.828 | 0.064 | -3 | 0.739 |
PRKX |
0.827 | 0.075 | -3 | 0.679 |
PINK1 |
0.827 | -0.093 | 1 | 0.788 |
DYRK4 |
0.827 | 0.036 | 1 | 0.565 |
HIPK3 |
0.827 | 0.016 | 1 | 0.642 |
PHKG2 |
0.827 | -0.005 | -3 | 0.821 |
DYRK3 |
0.827 | 0.057 | 1 | 0.653 |
PKCT |
0.826 | 0.033 | 2 | 0.808 |
IRAK4 |
0.826 | -0.039 | 1 | 0.769 |
DYRK1A |
0.826 | 0.002 | 1 | 0.673 |
PKCI |
0.826 | 0.059 | 2 | 0.828 |
ERK2 |
0.826 | -0.025 | 1 | 0.618 |
MEK5 |
0.826 | -0.113 | 2 | 0.856 |
TAO3 |
0.825 | 0.077 | 1 | 0.746 |
BMPR1A |
0.825 | 0.057 | 1 | 0.780 |
SSTK |
0.825 | -0.006 | 4 | 0.874 |
PLK4 |
0.825 | -0.072 | 2 | 0.640 |
MAPKAPK5 |
0.825 | -0.112 | -3 | 0.714 |
P38D |
0.825 | 0.038 | 1 | 0.522 |
ZAK |
0.825 | -0.059 | 1 | 0.719 |
GRK7 |
0.825 | -0.021 | 1 | 0.746 |
LKB1 |
0.824 | 0.114 | -3 | 0.896 |
BRAF |
0.824 | -0.063 | -4 | 0.841 |
MEKK2 |
0.824 | -0.030 | 2 | 0.846 |
SMMLCK |
0.823 | -0.008 | -3 | 0.824 |
MEKK3 |
0.823 | -0.103 | 1 | 0.753 |
CDK10 |
0.823 | 0.034 | 1 | 0.580 |
DYRK1B |
0.821 | 0.011 | 1 | 0.595 |
GRK2 |
0.821 | -0.024 | -2 | 0.730 |
CAMKK1 |
0.821 | -0.021 | -2 | 0.843 |
PKCE |
0.821 | 0.069 | 2 | 0.814 |
GAK |
0.821 | 0.099 | 1 | 0.839 |
CAMK1D |
0.821 | 0.000 | -3 | 0.686 |
TLK1 |
0.820 | -0.080 | -2 | 0.844 |
P70S6K |
0.820 | -0.021 | -3 | 0.701 |
PKACA |
0.820 | 0.041 | -2 | 0.683 |
TAO2 |
0.820 | 0.022 | 2 | 0.899 |
AKT1 |
0.820 | 0.038 | -3 | 0.705 |
NEK8 |
0.820 | -0.023 | 2 | 0.876 |
DAPK3 |
0.820 | 0.051 | -3 | 0.803 |
PAK5 |
0.818 | 0.033 | -2 | 0.730 |
CAMKK2 |
0.818 | 0.002 | -2 | 0.848 |
PASK |
0.818 | -0.024 | -3 | 0.850 |
NEK4 |
0.818 | 0.002 | 1 | 0.736 |
CK2A2 |
0.818 | 0.020 | 1 | 0.719 |
DCAMKL2 |
0.817 | -0.047 | -3 | 0.821 |
MEKK6 |
0.817 | 0.041 | 1 | 0.761 |
CK1E |
0.817 | -0.023 | -3 | 0.542 |
GSK3B |
0.816 | 0.009 | 4 | 0.507 |
CDK6 |
0.816 | 0.014 | 1 | 0.572 |
EEF2K |
0.816 | 0.019 | 3 | 0.634 |
NEK1 |
0.815 | 0.067 | 1 | 0.759 |
GSK3A |
0.815 | 0.039 | 4 | 0.512 |
GCK |
0.815 | 0.042 | 1 | 0.744 |
MST2 |
0.814 | 0.017 | 1 | 0.747 |
TNIK |
0.814 | 0.047 | 3 | 0.682 |
VRK1 |
0.814 | 0.098 | 2 | 0.853 |
PBK |
0.814 | 0.126 | 1 | 0.783 |
PAK4 |
0.814 | 0.029 | -2 | 0.734 |
PKN1 |
0.814 | 0.004 | -3 | 0.728 |
DAPK1 |
0.814 | 0.038 | -3 | 0.784 |
NEK11 |
0.813 | -0.122 | 1 | 0.730 |
MOK |
0.813 | 0.084 | 1 | 0.706 |
IRAK1 |
0.813 | -0.203 | -1 | 0.745 |
MINK |
0.812 | 0.012 | 1 | 0.729 |
HGK |
0.812 | -0.006 | 3 | 0.667 |
PDK1 |
0.812 | -0.046 | 1 | 0.736 |
MAK |
0.812 | 0.089 | -2 | 0.799 |
CDK4 |
0.811 | 0.004 | 1 | 0.544 |
HPK1 |
0.811 | 0.028 | 1 | 0.720 |
LRRK2 |
0.811 | -0.025 | 2 | 0.897 |
ROCK2 |
0.811 | 0.097 | -3 | 0.802 |
TTBK1 |
0.811 | -0.152 | 2 | 0.679 |
BUB1 |
0.810 | 0.078 | -5 | 0.806 |
TAK1 |
0.810 | 0.011 | 1 | 0.774 |
MAP3K15 |
0.810 | -0.024 | 1 | 0.710 |
MRCKB |
0.809 | 0.047 | -3 | 0.746 |
CAMK1A |
0.809 | -0.000 | -3 | 0.652 |
LOK |
0.809 | 0.008 | -2 | 0.860 |
YSK1 |
0.809 | 0.065 | 2 | 0.870 |
CK2A1 |
0.809 | 0.014 | 1 | 0.701 |
CK1G1 |
0.807 | -0.057 | -3 | 0.528 |
JNK1 |
0.807 | -0.017 | 1 | 0.543 |
KHS1 |
0.807 | 0.027 | 1 | 0.706 |
KHS2 |
0.807 | 0.052 | 1 | 0.722 |
NEK3 |
0.806 | 0.039 | 1 | 0.706 |
AKT3 |
0.806 | 0.024 | -3 | 0.611 |
CHK2 |
0.806 | -0.025 | -3 | 0.631 |
CK1D |
0.806 | -0.042 | -3 | 0.496 |
MRCKA |
0.806 | 0.022 | -3 | 0.761 |
GRK3 |
0.805 | -0.030 | -2 | 0.666 |
SGK1 |
0.805 | 0.023 | -3 | 0.592 |
MST1 |
0.804 | -0.048 | 1 | 0.729 |
MEK2 |
0.803 | -0.099 | 2 | 0.822 |
CK1A2 |
0.802 | -0.050 | -3 | 0.490 |
MYO3B |
0.800 | 0.088 | 2 | 0.883 |
BIKE |
0.800 | 0.113 | 1 | 0.736 |
SBK |
0.800 | -0.008 | -3 | 0.549 |
DMPK1 |
0.799 | 0.058 | -3 | 0.763 |
PLK2 |
0.799 | -0.065 | -3 | 0.777 |
PDHK3_TYR |
0.799 | 0.142 | 4 | 0.930 |
SLK |
0.799 | -0.061 | -2 | 0.798 |
STK33 |
0.798 | -0.141 | 2 | 0.662 |
RIPK2 |
0.798 | -0.226 | 1 | 0.676 |
ROCK1 |
0.797 | 0.058 | -3 | 0.766 |
PKG1 |
0.794 | -0.004 | -2 | 0.652 |
TESK1_TYR |
0.793 | 0.002 | 3 | 0.705 |
OSR1 |
0.793 | 0.007 | 2 | 0.835 |
TTK |
0.792 | -0.008 | -2 | 0.876 |
PKMYT1_TYR |
0.792 | 0.047 | 3 | 0.694 |
TAO1 |
0.792 | 0.007 | 1 | 0.663 |
HASPIN |
0.792 | 0.017 | -1 | 0.692 |
MAP2K4_TYR |
0.792 | 0.012 | -1 | 0.873 |
PDHK4_TYR |
0.792 | 0.044 | 2 | 0.894 |
LIMK2_TYR |
0.791 | 0.091 | -3 | 0.926 |
CRIK |
0.790 | 0.008 | -3 | 0.695 |
MAP2K6_TYR |
0.789 | -0.002 | -1 | 0.867 |
MYO3A |
0.788 | -0.019 | 1 | 0.712 |
MAP2K7_TYR |
0.788 | -0.119 | 2 | 0.879 |
BMPR2_TYR |
0.788 | 0.017 | -1 | 0.847 |
AAK1 |
0.787 | 0.140 | 1 | 0.653 |
PINK1_TYR |
0.785 | -0.122 | 1 | 0.800 |
ASK1 |
0.785 | -0.104 | 1 | 0.693 |
PDHK1_TYR |
0.785 | -0.050 | -1 | 0.868 |
ABL2 |
0.784 | 0.075 | -1 | 0.787 |
EPHA6 |
0.784 | 0.004 | -1 | 0.832 |
EPHB4 |
0.783 | 0.004 | -1 | 0.823 |
LIMK1_TYR |
0.783 | -0.054 | 2 | 0.879 |
ABL1 |
0.783 | 0.080 | -1 | 0.782 |
RET |
0.782 | -0.080 | 1 | 0.746 |
TYRO3 |
0.780 | -0.065 | 3 | 0.636 |
TYK2 |
0.780 | -0.108 | 1 | 0.739 |
FGR |
0.780 | 0.009 | 1 | 0.837 |
TXK |
0.779 | 0.104 | 1 | 0.824 |
ROS1 |
0.779 | -0.070 | 3 | 0.617 |
MST1R |
0.778 | -0.113 | 3 | 0.653 |
JAK2 |
0.778 | -0.116 | 1 | 0.731 |
TNK2 |
0.778 | -0.017 | 3 | 0.594 |
YES1 |
0.777 | -0.030 | -1 | 0.833 |
TNNI3K_TYR |
0.776 | 0.057 | 1 | 0.744 |
DDR1 |
0.776 | -0.134 | 4 | 0.868 |
CSF1R |
0.774 | -0.114 | 3 | 0.630 |
LCK |
0.774 | 0.019 | -1 | 0.805 |
ITK |
0.774 | 0.011 | -1 | 0.777 |
HCK |
0.774 | -0.042 | -1 | 0.811 |
BLK |
0.773 | 0.035 | -1 | 0.823 |
SRMS |
0.773 | -0.019 | 1 | 0.815 |
JAK3 |
0.773 | -0.112 | 1 | 0.743 |
EPHB3 |
0.772 | -0.044 | -1 | 0.807 |
FER |
0.772 | -0.118 | 1 | 0.833 |
EPHB1 |
0.772 | -0.064 | 1 | 0.807 |
YANK3 |
0.771 | -0.089 | 2 | 0.445 |
TNK1 |
0.771 | -0.037 | 3 | 0.636 |
JAK1 |
0.771 | -0.029 | 1 | 0.676 |
EPHA4 |
0.771 | -0.054 | 2 | 0.793 |
INSRR |
0.770 | -0.118 | 3 | 0.582 |
CK1A |
0.770 | -0.034 | -3 | 0.398 |
ALPHAK3 |
0.769 | -0.176 | -1 | 0.746 |
EPHB2 |
0.769 | -0.048 | -1 | 0.802 |
STLK3 |
0.769 | -0.159 | 1 | 0.683 |
PDGFRB |
0.769 | -0.139 | 3 | 0.634 |
NEK10_TYR |
0.768 | -0.073 | 1 | 0.637 |
MERTK |
0.766 | -0.064 | 3 | 0.616 |
KDR |
0.766 | -0.129 | 3 | 0.587 |
TEC |
0.765 | -0.050 | -1 | 0.723 |
AXL |
0.765 | -0.120 | 3 | 0.604 |
PDGFRA |
0.764 | -0.162 | 3 | 0.644 |
LTK |
0.764 | -0.109 | 3 | 0.600 |
KIT |
0.763 | -0.170 | 3 | 0.622 |
BMX |
0.763 | -0.037 | -1 | 0.689 |
PTK2B |
0.763 | -0.008 | -1 | 0.767 |
FGFR2 |
0.763 | -0.201 | 3 | 0.612 |
FLT3 |
0.762 | -0.183 | 3 | 0.621 |
BTK |
0.762 | -0.143 | -1 | 0.736 |
ALK |
0.762 | -0.142 | 3 | 0.571 |
EPHA7 |
0.762 | -0.082 | 2 | 0.802 |
NTRK1 |
0.761 | -0.142 | -1 | 0.793 |
FYN |
0.761 | -0.021 | -1 | 0.782 |
TEK |
0.761 | -0.197 | 3 | 0.570 |
PTK6 |
0.761 | -0.110 | -1 | 0.700 |
MET |
0.760 | -0.130 | 3 | 0.622 |
FGFR1 |
0.760 | -0.197 | 3 | 0.597 |
EPHA1 |
0.760 | -0.111 | 3 | 0.591 |
DDR2 |
0.760 | -0.065 | 3 | 0.560 |
EPHA3 |
0.760 | -0.120 | 2 | 0.771 |
LYN |
0.759 | -0.088 | 3 | 0.571 |
WEE1_TYR |
0.758 | -0.107 | -1 | 0.709 |
FRK |
0.756 | -0.126 | -1 | 0.817 |
FLT1 |
0.756 | -0.133 | -1 | 0.798 |
NTRK2 |
0.755 | -0.193 | 3 | 0.592 |
INSR |
0.755 | -0.158 | 3 | 0.573 |
FLT4 |
0.755 | -0.174 | 3 | 0.597 |
NTRK3 |
0.754 | -0.139 | -1 | 0.743 |
EPHA5 |
0.754 | -0.095 | 2 | 0.778 |
SRC |
0.754 | -0.074 | -1 | 0.790 |
ERBB2 |
0.753 | -0.195 | 1 | 0.706 |
EPHA8 |
0.751 | -0.104 | -1 | 0.781 |
FGFR3 |
0.750 | -0.225 | 3 | 0.585 |
PTK2 |
0.749 | -0.002 | -1 | 0.754 |
MATK |
0.748 | -0.134 | -1 | 0.700 |
CSK |
0.747 | -0.153 | 2 | 0.804 |
CK1G3 |
0.743 | -0.096 | -3 | 0.349 |
EGFR |
0.743 | -0.123 | 1 | 0.617 |
MUSK |
0.742 | -0.128 | 1 | 0.628 |
EPHA2 |
0.740 | -0.115 | -1 | 0.744 |
FGFR4 |
0.740 | -0.159 | -1 | 0.748 |
SYK |
0.740 | -0.043 | -1 | 0.743 |
IGF1R |
0.740 | -0.166 | 3 | 0.523 |
YANK2 |
0.737 | -0.116 | 2 | 0.460 |
ERBB4 |
0.729 | -0.128 | 1 | 0.636 |
FES |
0.729 | -0.142 | -1 | 0.667 |
CK1G2 |
0.719 | -0.113 | -3 | 0.447 |
ZAP70 |
0.715 | -0.103 | -1 | 0.658 |