Motif 940 (n=210)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S285 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A0FGR8 | ESYT2 | S513 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| B1AJZ9 | FHAD1 | S717 | ochoa | Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1) | Regulator of sperm motility and spermatocyte meiosis. {ECO:0000250|UniProtKB:A6PWD2}. |
| B2RTY4 | MYO9A | S1299 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O00391 | QSOX1 | S426 | ochoa | Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6) | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560). {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449, ECO:0000269|PubMed:22801504, ECO:0000269|PubMed:23704371, ECO:0000269|PubMed:23867277, ECO:0000269|PubMed:30367560}. |
| O00515 | LAD1 | S49 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O15446 | POLR1G | S420 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O43294 | TGFB1I1 | S177 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43399 | TPD52L2 | S145 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O60293 | ZFC3H1 | S381 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60303 | KATNIP | S678 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O60711 | LPXN | S23 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
| O75052 | NOS1AP | S371 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75155 | CAND2 | S1166 | ochoa | Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2) | Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. {ECO:0000250}. |
| O75376 | NCOR1 | S1284 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75385 | ULK1 | S340 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75396 | SEC22B | S175 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O75717 | WDHD1 | S853 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O75792 | RNASEH2A | S277 | ochoa | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| O75940 | SMNDC1 | S61 | ochoa | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
| O95071 | UBR5 | S201 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95235 | KIF20A | S244 | psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95684 | CEP43 | S326 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| P04233 | CD74 | S42 | psp | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}. |
| P05198 | EIF2S1 | S49 | ochoa|psp | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P06239 | LCK | Y263 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P08833 | IGFBP1 | S199 | psp | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}. |
| P09601 | HMOX1 | S229 | ochoa | Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] | [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707). {ECO:0000269|PubMed:11121422, ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:7703255, ECO:0000303|PubMed:20055707}.; FUNCTION: [Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. {ECO:0000269|PubMed:35239449}.; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7703255}. |
| P09874 | PARP1 | S277 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P10586 | PTPRF | S167 | ochoa | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| P11277 | SPTB | S1376 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P12882 | MYH1 | S1331 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P15336 | ATF2 | S121 | psp | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P17028 | ZNF24 | S142 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P18887 | XRCC1 | S357 | psp | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P20309 | CHRM3 | S413 | ochoa | Muscarinic acetylcholine receptor M3 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}. |
| P22670 | RFX1 | S949 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P23193 | TCEA1 | S81 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P28715 | ERCC5 | S697 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29536 | LMOD1 | S44 | ochoa | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}. |
| P30622 | CLIP1 | S973 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P30740 | SERPINB1 | S300 | ochoa | Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). {ECO:0000269|PubMed:11747453, ECO:0000269|PubMed:23269243, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}. |
| P32004 | L1CAM | S1191 | ochoa | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P32241 | VIPR1 | S250 | psp | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P32298 | GRK4 | S249 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P35221 | CTNNA1 | S44 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35568 | IRS1 | S604 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35579 | MYH9 | S1290 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P42704 | LRPPRC | S1026 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P43487 | RANBP1 | S60 | ochoa|psp | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}. |
| P46013 | MKI67 | S325 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48549 | KCNJ3 | S401 | psp | G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:8804710, PubMed:8868049). This receptor plays a crucial role in regulating the heartbeat (By similarity). {ECO:0000250|UniProtKB:P63251, ECO:0000269|PubMed:8804710, ECO:0000269|PubMed:8868049}. |
| P48681 | NES | S1307 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49327 | FASN | S1398 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S1422 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2831 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S1364 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P51116 | FXR2 | S397 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P53675 | CLTCL1 | S1016 | ochoa | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
| P54132 | BLM | S527 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54259 | ATN1 | S39 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P56945 | BCAR1 | S694 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P61266 | STX1B | S58 | ochoa | Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2) | Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). {ECO:0000250}. |
| P62906 | RPL10A | S50 | ochoa | Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P78356 | PIP4K2B | S319 | ochoa | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9038203}. |
| Q00534 | CDK6 | S293 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q00610 | CLTC | S1016 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q03001 | DST | S1692 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q08211 | DHX9 | S305 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12888 | TP53BP1 | S862 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1019 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12923 | PTPN13 | S499 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13045 | FLII | S64 | psp | Protein flightless-1 homolog | Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling. {ECO:0000250|UniProtKB:Q9JJ28, ECO:0000269|PubMed:14966289}. |
| Q13416 | ORC2 | S255 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13444 | ADAM15 | S56 | ochoa | Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin) | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}. |
| Q13501 | SQSTM1 | S365 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q14005 | IL16 | S1073 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14151 | SAFB2 | S54 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14157 | UBAP2L | S265 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14202 | ZMYM3 | S957 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14674 | ESPL1 | S1545 | ochoa|psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q14676 | MDC1 | S1508 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14679 | TTLL4 | S912 | psp | Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) | Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q80UG8}. |
| Q14692 | BMS1 | S624 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q14790 | CASP8 | S26 | ochoa | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| Q14966 | ZNF638 | S1490 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15393 | SF3B3 | S156 | ochoa | Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10490618, PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10490618, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q15424 | SAFB | S55 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15691 | MAPRE1 | S40 | psp | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
| Q15758 | SLC1A5 | S493 | ochoa | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
| Q15797 | SMAD1 | S151 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q2NKX8 | ERCC6L | S864 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q5JTJ3 | COA6 | S85 | ochoa | Cytochrome c oxidase assembly factor 6 homolog | Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. {ECO:0000269|PubMed:24549041, ECO:0000269|PubMed:25959673, ECO:0000269|PubMed:26160915}. |
| Q5M775 | SPECC1 | S617 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5QJ74 | TBCEL | S342 | ochoa | Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) | Acts as a regulator of tubulin stability. {ECO:0000269|PubMed:15728251}. |
| Q5SW79 | CEP170 | S122 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T5Y3 | CAMSAP1 | S1239 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TC82 | RC3H1 | S808 | ochoa | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25026078, PubMed:25504471). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250|UniProtKB:Q4VGL6, ECO:0000269|PubMed:25026078, ECO:0000269|PubMed:25504471, ECO:0000269|PubMed:25697406, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:31636267}. |
| Q5TF21 | MTCL3 | S569 | ochoa | Microtubule cross-linking factor 3 | None |
| Q5UIP0 | RIF1 | S1157 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1394 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VST9 | OBSCN | S4804 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT06 | CEP350 | S1807 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT06 | CEP350 | S2174 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VTT5 | MYOM3 | S1049 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q5VUB5 | FAM171A1 | S360 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VUB5 | FAM171A1 | S443 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q6P4F7 | ARHGAP11A | S291 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P597 | KLC3 | S162 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q6PKG0 | LARP1 | S492 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6VY07 | PACS1 | S381 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZNJ1 | NBEAL2 | S1873 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZUJ8 | PIK3AP1 | S421 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q6ZVD8 | PHLPP2 | S307 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Q6ZW76 | ANKS3 | S375 | ochoa | Ankyrin repeat and SAM domain-containing protein 3 | May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}. |
| Q7L0Y3 | TRMT10C | S73 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
| Q7Z2Z1 | TICRR | S1582 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z434 | MAVS | S430 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z4H7 | HAUS6 | S556 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z5J4 | RAI1 | S1394 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6Z7 | HUWE1 | S2394 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86U86 | PBRM1 | S952 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86XP1 | DGKH | S608 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q8IU68 | TMC8 | S658 | ochoa | Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q8IV53 | DENND1C | S576 | ochoa | DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8IX01 | SUGP2 | S92 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8N0Z3 | SPICE1 | S232 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N4C6 | NIN | S1306 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N573 | OXR1 | S364 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5C1 | CALHM5 | S238 | ochoa | Calcium homeostasis modulator protein 5 (Protein FAM26E) | May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids. {ECO:0000269|PubMed:33298887}. |
| Q8N7Z5 | ANKRD31 | S43 | ochoa | Ankyrin repeat domain-containing protein 31 | Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes. {ECO:0000250|UniProtKB:A0A140LI88}. |
| Q8NEG4 | FAM83F | S316 | ochoa | Protein FAM83F | None |
| Q8NFW8 | CMAS | S387 | ochoa | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). |
| Q8TDY2 | RB1CC1 | S229 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TF72 | SHROOM3 | S663 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUY3 | PRUNE2 | S737 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WUY3 | PRUNE2 | S2698 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WZ75 | ROBO4 | S816 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92547 | TOPBP1 | S1192 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q96IT1 | ZNF496 | S295 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96NR8 | RDH12 | S174 | ochoa | Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:15865448, PubMed:19686838). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:12226107, PubMed:15865448). {ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:19686838}. |
| Q96T51 | RUFY1 | S172 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q96T51 | RUFY1 | S618 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q99550 | MPHOSPH9 | S1133 | ochoa | M-phase phosphoprotein 9 | Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}. |
| Q99717 | SMAD5 | S152 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q99983 | OMD | S226 | ochoa | Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) | May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}. |
| Q9BT88 | SYT11 | S144 | ochoa | Synaptotagmin-11 (Synaptotagmin XI) (SytXI) | Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). {ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:27278822}. |
| Q9BV38 | WDR18 | S371 | ochoa | WD repeat-containing protein 18 | Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity). {ECO:0000250|UniProtKB:Q68EI0, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q9BV73 | CEP250 | S2234 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BVJ6 | UTP14A | S437 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BXF6 | RAB11FIP5 | S418 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9H4G4 | GLIPR2 | S58 | ochoa | Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) | None |
| Q9H4I2 | ZHX3 | S708 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H4L4 | SENP3 | S355 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H7E2 | TDRD3 | S80 | ochoa | Tudor domain-containing protein 3 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}. |
| Q9HAW7 | UGT1A7 | S432 | psp | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:20610558, PubMed:23360619, PubMed:21422672, PubMed:38211441). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol (PubMed:18719240). Involved in the glucuronidation of F2-isoprostane (5-epi-5-F2t-IsoP) (PubMed:38211441). Involved in the glucuronidation of the phytochemical ferulic acid at the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558, PubMed:23360619). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:21422672, ECO:0000269|PubMed:23360619, ECO:0000269|PubMed:38211441}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:23360619}. |
| Q9HAW8 | UGT1A10 | S432 | psp | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143, PubMed:15231852, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and PGB1 (PubMed:15231852). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). {ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15231852, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:21422672, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:26220143}.; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}. |
| Q9HCM4 | EPB41L5 | S39 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9HCM7 | FBRSL1 | S787 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NP61 | ARFGAP3 | S212 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NR30 | DDX21 | S466 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NS87 | KIF15 | S403 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9NV66 | TYW1 | S376 | ochoa | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein) | Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). {ECO:0000250}. |
| Q9NX95 | SYBU | S400 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9NY74 | ETAA1 | S342 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZC9 | SMARCAL1 | S652 | psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9P0K7 | RAI14 | S478 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P266 | JCAD | S185 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2E7 | PCDH10 | S897 | ochoa | Protocadherin-10 | Potential calcium-dependent cell-adhesion protein.; FUNCTION: (Microbial infection) Acts as a receptor for Western equine encephalitis virus. {ECO:0000269|PubMed:39048821}. |
| Q9P2K8 | EIF2AK4 | S213 | ochoa | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| Q9UHG2 | PCSK1N | S206 | ochoa | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}. |
| Q9UHW9 | SLC12A6 | S147 | ochoa | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
| Q9UI14 | RABAC1 | S28 | ochoa | Prenylated Rab acceptor protein 1 (PRA1 family protein 1) | General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. {ECO:0000250|UniProtKB:O35394}. |
| Q9ULC8 | ZDHHC8 | S286 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULT8 | HECTD1 | S248 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9ULV0 | MYO5B | S978 | ochoa | Unconventional myosin-Vb | May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459). {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:34816459}. |
| Q9UPM8 | AP4E1 | S847 | ochoa|psp | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UQM7 | CAMK2A | S404 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y244 | POMP | S22 | ochoa | Proteasome maturation protein (Proteassemblin) (Protein UMP1 homolog) (hUMP1) (Voltage-gated K channel beta subunit 4.1) | Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. {ECO:0000269|PubMed:15944226, ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17948026}. |
| Q9Y294 | ASF1A | S172 | ochoa | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}. |
| Q9Y2Z0 | SUGT1 | S321 | ochoa|psp | Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
| Q9Y462 | ZNF711 | S227 | ochoa | Zinc finger protein 711 (Zinc finger protein 6) | Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}. |
| Q9Y4B5 | MTCL1 | S549 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F5 | CEP170B | S907 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y5A6 | ZSCAN21 | S135 | ochoa | Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) | Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q07231}. |
| Q9Y6X4 | FAM169A | S526 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| R4GMW8 | BIVM-ERCC5 | S1151 | ochoa | DNA excision repair protein ERCC-5 | None |
| P37108 | SRP14 | S25 | Sugiyama | Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:11089964). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (PubMed:11089964). {ECO:0000269|PubMed:11089964}. |
| P62917 | RPL8 | S138 | Sugiyama | Large ribosomal subunit protein uL2 (60S ribosomal protein L8) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| O60763 | USO1 | S751 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| P20810 | CAST | S337 | Sugiyama | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P33240 | CSTF2 | S44 | Sugiyama | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| Q15643 | TRIP11 | S406 | Sugiyama | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q9Y2T3 | GDA | S263 | Sugiyama | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}. |
| P25786 | PSMA1 | S211 | Sugiyama | Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P31327 | CPS1 | S759 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P29401 | TKT | S443 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| Q15776 | ZKSCAN8 | S141 | PSP | Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) | May be involved in transcriptional regulation. |
| P42684 | ABL2 | S146 | Sugiyama | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| Q96KB5 | PBK | S298 | Sugiyama | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| Q14980 | NUMA1 | S861 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| P18754 | RCC1 | S129 | Sugiyama | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
| Q9GZM8 | NDEL1 | S95 | PSP | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| P43243 | MATR3 | S240 | Sugiyama | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P49327 | FASN | S324 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8IW41 | MAPKAPK5 | S33 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| P17987 | TCP1 | S119 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49327 | FASN | T1150 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q9BT09 | CNPY3 | S205 | Sugiyama | Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) | Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}. |
| Q8N584 | TTC39C | S472 | Sugiyama | Tetratricopeptide repeat protein 39C (TPR repeat protein 39C) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.003397 | 2.469 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.003470 | 2.460 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.001666 | 2.778 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.003670 | 2.435 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.001396 | 2.855 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.003043 | 2.517 |
| R-HSA-9707616 | Heme signaling | 0.003428 | 2.465 |
| R-HSA-72312 | rRNA processing | 0.003481 | 2.458 |
| R-HSA-68877 | Mitotic Prometaphase | 0.003553 | 2.449 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.003816 | 2.418 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.003954 | 2.403 |
| R-HSA-68886 | M Phase | 0.002021 | 2.694 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.002272 | 2.644 |
| R-HSA-1640170 | Cell Cycle | 0.001772 | 2.752 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.003389 | 2.470 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.004581 | 2.339 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.004535 | 2.343 |
| R-HSA-199991 | Membrane Trafficking | 0.007378 | 2.132 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.008014 | 2.096 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.008427 | 2.074 |
| R-HSA-196025 | Formation of annular gap junctions | 0.010901 | 1.963 |
| R-HSA-190873 | Gap junction degradation | 0.012854 | 1.891 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.011430 | 1.942 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.011430 | 1.942 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.012933 | 1.888 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.010901 | 1.963 |
| R-HSA-5693538 | Homology Directed Repair | 0.011910 | 1.924 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.011641 | 1.934 |
| R-HSA-156588 | Glucuronidation | 0.012201 | 1.914 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.010974 | 1.960 |
| R-HSA-9711097 | Cellular response to starvation | 0.013439 | 1.872 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.017177 | 1.765 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.019041 | 1.720 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.019041 | 1.720 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.021755 | 1.662 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.028970 | 1.538 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.028131 | 1.551 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.029010 | 1.537 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.018228 | 1.739 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.028273 | 1.549 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.029010 | 1.537 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.018892 | 1.724 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.024638 | 1.608 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.015849 | 1.800 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.026739 | 1.573 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.027863 | 1.555 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.021709 | 1.663 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.029853 | 1.525 |
| R-HSA-381042 | PERK regulates gene expression | 0.022413 | 1.649 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.019537 | 1.709 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.024638 | 1.608 |
| R-HSA-69481 | G2/M Checkpoints | 0.016465 | 1.783 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.029906 | 1.524 |
| R-HSA-162906 | HIV Infection | 0.025599 | 1.592 |
| R-HSA-68882 | Mitotic Anaphase | 0.020227 | 1.694 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.020679 | 1.684 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.028131 | 1.551 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.028131 | 1.551 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.017177 | 1.765 |
| R-HSA-168255 | Influenza Infection | 0.023748 | 1.624 |
| R-HSA-2262752 | Cellular responses to stress | 0.023109 | 1.636 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.021489 | 1.668 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.030104 | 1.521 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 0.041591 | 1.381 |
| R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 0.041591 | 1.381 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 0.041591 | 1.381 |
| R-HSA-9918440 | Defective visual phototransduction due to RDH12 loss of function | 0.055068 | 1.259 |
| R-HSA-8941237 | Invadopodia formation | 0.068357 | 1.165 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.081459 | 1.089 |
| R-HSA-74713 | IRS activation | 0.094378 | 1.025 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.107116 | 0.970 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.107116 | 0.970 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.119676 | 0.922 |
| R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 0.119676 | 0.922 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.119676 | 0.922 |
| R-HSA-3656225 | Defective CHST6 causes MCDC1 | 0.119676 | 0.922 |
| R-HSA-3656243 | Defective ST3GAL3 causes MCT12 and EIEE15 | 0.119676 | 0.922 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.132060 | 0.879 |
| R-HSA-112412 | SOS-mediated signalling | 0.132060 | 0.879 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.132060 | 0.879 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.144270 | 0.841 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.144270 | 0.841 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.156310 | 0.806 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.156310 | 0.806 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.168180 | 0.774 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.080277 | 1.095 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.214023 | 0.670 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.214023 | 0.670 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.088694 | 1.052 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.225085 | 0.648 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.246746 | 0.608 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.246746 | 0.608 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.115353 | 0.938 |
| R-HSA-380287 | Centrosome maturation | 0.031263 | 1.505 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.257350 | 0.589 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.267805 | 0.572 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.288277 | 0.540 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.054966 | 1.260 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.298298 | 0.525 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.298298 | 0.525 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.298298 | 0.525 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.298298 | 0.525 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.056595 | 1.247 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.063368 | 1.198 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.317921 | 0.498 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.317921 | 0.498 |
| R-HSA-437239 | Recycling pathway of L1 | 0.183450 | 0.736 |
| R-HSA-192823 | Viral mRNA Translation | 0.080082 | 1.096 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.346336 | 0.461 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.346336 | 0.461 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.214167 | 0.669 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.355543 | 0.449 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.229706 | 0.639 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.240107 | 0.620 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.373572 | 0.428 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.373572 | 0.428 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.382397 | 0.417 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.382397 | 0.417 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.399678 | 0.398 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.408137 | 0.389 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.408137 | 0.389 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.424701 | 0.372 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.424701 | 0.372 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.070975 | 1.149 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.053363 | 1.273 |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 0.424701 | 0.372 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.417101 | 0.380 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.214023 | 0.670 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.100945 | 0.996 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.194517 | 0.711 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.408137 | 0.389 |
| R-HSA-198203 | PI3K/AKT activation | 0.168180 | 0.774 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.257350 | 0.589 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.143726 | 0.842 |
| R-HSA-156902 | Peptide chain elongation | 0.050234 | 1.299 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.100945 | 0.996 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.399678 | 0.398 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.107116 | 0.970 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.373572 | 0.428 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.038755 | 1.412 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.298298 | 0.525 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.038755 | 1.412 |
| R-HSA-9620244 | Long-term potentiation | 0.355543 | 0.449 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.373572 | 0.428 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.114721 | 0.940 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.086094 | 1.065 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.143028 | 0.845 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.081459 | 1.089 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.094378 | 1.025 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.132060 | 0.879 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.132060 | 0.879 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.106252 | 0.974 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.355543 | 0.449 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.355543 | 0.449 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.355543 | 0.449 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.424701 | 0.372 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.327527 | 0.485 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.398910 | 0.399 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.364621 | 0.438 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.065125 | 1.186 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.105393 | 0.977 |
| R-HSA-373760 | L1CAM interactions | 0.280112 | 0.553 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.245317 | 0.610 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.038765 | 1.412 |
| R-HSA-2424491 | DAP12 signaling | 0.399678 | 0.398 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.287056 | 0.542 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.056673 | 1.247 |
| R-HSA-525793 | Myogenesis | 0.364621 | 0.438 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.302670 | 0.519 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.156310 | 0.806 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.115353 | 0.938 |
| R-HSA-9907900 | Proteasome assembly | 0.168351 | 0.774 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.257350 | 0.589 |
| R-HSA-445144 | Signal transduction by L1 | 0.298298 | 0.525 |
| R-HSA-201451 | Signaling by BMP | 0.080277 | 1.095 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.364621 | 0.438 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.207348 | 0.683 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 0.041591 | 1.381 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 0.041591 | 1.381 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 0.081459 | 1.089 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.107116 | 0.970 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.144270 | 0.841 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.168180 | 0.774 |
| R-HSA-192814 | vRNA Synthesis | 0.179885 | 0.745 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.191425 | 0.718 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.191425 | 0.718 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.202804 | 0.693 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.214023 | 0.670 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.115353 | 0.938 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.278113 | 0.556 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.065125 | 1.186 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.317921 | 0.498 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.317921 | 0.498 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.327527 | 0.485 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.336998 | 0.472 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.209009 | 0.680 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.346336 | 0.461 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.234903 | 0.629 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.382397 | 0.417 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.183861 | 0.736 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.408137 | 0.389 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.297471 | 0.527 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.287056 | 0.542 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.235992 | 0.627 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.408137 | 0.389 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.424701 | 0.372 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.404277 | 0.393 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.202804 | 0.693 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.058250 | 1.235 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.399678 | 0.398 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 0.168180 | 0.774 |
| R-HSA-74749 | Signal attenuation | 0.168180 | 0.774 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.115353 | 0.938 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.131379 | 0.881 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.307863 | 0.512 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.146306 | 0.835 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 0.094378 | 1.025 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.132060 | 0.879 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.156310 | 0.806 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.168180 | 0.774 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.246746 | 0.608 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.134107 | 0.873 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.298298 | 0.525 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.056728 | 1.246 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.346336 | 0.461 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.060812 | 1.216 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.214023 | 0.670 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.225085 | 0.648 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.139774 | 0.855 |
| R-HSA-983189 | Kinesins | 0.073199 | 1.135 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.037859 | 1.422 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 0.055068 | 1.259 |
| R-HSA-9675132 | Diseases of cellular response to stress | 0.055068 | 1.259 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 0.132060 | 0.879 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.191425 | 0.718 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.246746 | 0.608 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.042870 | 1.368 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.308179 | 0.511 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.399678 | 0.398 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.416477 | 0.380 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.381864 | 0.418 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.148589 | 0.828 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.423810 | 0.373 |
| R-HSA-9664873 | Pexophagy | 0.168180 | 0.774 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.046107 | 1.336 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.044294 | 1.354 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.168180 | 0.774 |
| R-HSA-9842663 | Signaling by LTK | 0.202804 | 0.693 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.260967 | 0.583 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.318224 | 0.497 |
| R-HSA-73894 | DNA Repair | 0.093254 | 1.030 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.168180 | 0.774 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.202804 | 0.693 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.225085 | 0.648 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.119976 | 0.921 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.257350 | 0.589 |
| R-HSA-2022857 | Keratan sulfate degradation | 0.298298 | 0.525 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.076195 | 1.118 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.260967 | 0.583 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.399678 | 0.398 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.416477 | 0.380 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.424701 | 0.372 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.048765 | 1.312 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.424701 | 0.372 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.046063 | 1.337 |
| R-HSA-8953854 | Metabolism of RNA | 0.036315 | 1.440 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.327527 | 0.485 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.192918 | 0.715 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.364621 | 0.438 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.055068 | 1.259 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.081459 | 1.089 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.132060 | 0.879 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.191425 | 0.718 |
| R-HSA-70635 | Urea cycle | 0.076169 | 1.118 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.235992 | 0.627 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.288277 | 0.540 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.336998 | 0.472 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.355543 | 0.449 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.373572 | 0.428 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.408137 | 0.389 |
| R-HSA-1632852 | Macroautophagy | 0.187238 | 0.728 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.132060 | 0.879 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.257350 | 0.589 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.373572 | 0.428 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.424701 | 0.372 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.178394 | 0.749 |
| R-HSA-5205647 | Mitophagy | 0.115353 | 0.938 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.424701 | 0.372 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.078274 | 1.106 |
| R-HSA-9843745 | Adipogenesis | 0.345430 | 0.462 |
| R-HSA-69275 | G2/M Transition | 0.073148 | 1.136 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.068357 | 1.165 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 0.094378 | 1.025 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.107116 | 0.970 |
| R-HSA-164944 | Nef and signal transduction | 0.119676 | 0.922 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.132060 | 0.879 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.156310 | 0.806 |
| R-HSA-5682910 | LGI-ADAM interactions | 0.179885 | 0.745 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.202804 | 0.693 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.202804 | 0.693 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.202804 | 0.693 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.298298 | 0.525 |
| R-HSA-190828 | Gap junction trafficking | 0.168351 | 0.774 |
| R-HSA-9766229 | Degradation of CDH1 | 0.193622 | 0.713 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.346336 | 0.461 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.250530 | 0.601 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.075822 | 1.120 |
| R-HSA-5617833 | Cilium Assembly | 0.078552 | 1.105 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.416477 | 0.380 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.223623 | 0.650 |
| R-HSA-9930044 | Nuclear RNA decay | 0.424701 | 0.372 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.424701 | 0.372 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.410235 | 0.387 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.424701 | 0.372 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.384436 | 0.415 |
| R-HSA-9612973 | Autophagy | 0.234058 | 0.631 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.382397 | 0.417 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.101778 | 0.992 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.246746 | 0.608 |
| R-HSA-9909396 | Circadian clock | 0.159718 | 0.797 |
| R-HSA-162587 | HIV Life Cycle | 0.237078 | 0.625 |
| R-HSA-622312 | Inflammasomes | 0.084454 | 1.073 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.225085 | 0.648 |
| R-HSA-449836 | Other interleukin signaling | 0.288277 | 0.540 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.318224 | 0.497 |
| R-HSA-73887 | Death Receptor Signaling | 0.228049 | 0.642 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.368450 | 0.434 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.178394 | 0.749 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.178394 | 0.749 |
| R-HSA-75893 | TNF signaling | 0.229706 | 0.639 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.283935 | 0.547 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.395122 | 0.403 |
| R-HSA-75158 | TRAIL signaling | 0.107116 | 0.970 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.156310 | 0.806 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.214023 | 0.670 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.225085 | 0.648 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.257350 | 0.589 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.124644 | 0.904 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.193622 | 0.713 |
| R-HSA-77387 | Insulin receptor recycling | 0.382397 | 0.417 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.093018 | 1.031 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.408137 | 0.389 |
| R-HSA-4086400 | PCP/CE pathway | 0.343956 | 0.463 |
| R-HSA-422475 | Axon guidance | 0.181926 | 0.740 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.418830 | 0.378 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.054240 | 1.266 |
| R-HSA-9663891 | Selective autophagy | 0.399345 | 0.399 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.168180 | 0.774 |
| R-HSA-9675108 | Nervous system development | 0.237683 | 0.624 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.424701 | 0.372 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.379431 | 0.421 |
| R-HSA-8964038 | LDL clearance | 0.327527 | 0.485 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.095682 | 1.019 |
| R-HSA-9675135 | Diseases of DNA repair | 0.178394 | 0.749 |
| R-HSA-210990 | PECAM1 interactions | 0.179885 | 0.745 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.084454 | 1.073 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.106252 | 0.974 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.298298 | 0.525 |
| R-HSA-8854214 | TBC/RABGAPs | 0.163368 | 0.787 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.373572 | 0.428 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.391099 | 0.408 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.399345 | 0.399 |
| R-HSA-73884 | Base Excision Repair | 0.409190 | 0.388 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.083499 | 1.078 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.112424 | 0.949 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.110778 | 0.956 |
| R-HSA-6782861 | Synthesis of wybutosine at G37 of tRNA(Phe) | 0.246746 | 0.608 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.278113 | 0.556 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.336998 | 0.472 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.391099 | 0.408 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.391099 | 0.408 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.266187 | 0.575 |
| R-HSA-354192 | Integrin signaling | 0.424701 | 0.372 |
| R-HSA-72306 | tRNA processing | 0.280204 | 0.553 |
| R-HSA-68875 | Mitotic Prophase | 0.295429 | 0.530 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.097620 | 1.010 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.179885 | 0.745 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.202804 | 0.693 |
| R-HSA-8963896 | HDL assembly | 0.225085 | 0.648 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.183450 | 0.736 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.424701 | 0.372 |
| R-HSA-2586552 | Signaling by Leptin | 0.168180 | 0.774 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.317921 | 0.498 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.036874 | 1.433 |
| R-HSA-9629569 | Protein hydroxylation | 0.298298 | 0.525 |
| R-HSA-210991 | Basigin interactions | 0.308179 | 0.511 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.120814 | 0.918 |
| R-HSA-9833482 | PKR-mediated signaling | 0.130171 | 0.885 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.364621 | 0.438 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.302670 | 0.519 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.067992 | 1.168 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.229706 | 0.639 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.119256 | 0.924 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.034864 | 1.458 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.246190 | 0.609 |
| R-HSA-9824446 | Viral Infection Pathways | 0.273438 | 0.563 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.278113 | 0.556 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.346336 | 0.461 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.346336 | 0.461 |
| R-HSA-1483255 | PI Metabolism | 0.216263 | 0.665 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.330041 | 0.481 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.246746 | 0.608 |
| R-HSA-9753281 | Paracetamol ADME | 0.224517 | 0.649 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.373572 | 0.428 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.408137 | 0.389 |
| R-HSA-163685 | Integration of energy metabolism | 0.173287 | 0.761 |
| R-HSA-202424 | Downstream TCR signaling | 0.409190 | 0.388 |
| R-HSA-162582 | Signal Transduction | 0.404660 | 0.393 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.416477 | 0.380 |
| R-HSA-2453864 | Retinoid cycle disease events | 0.355543 | 0.449 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.355543 | 0.449 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.152936 | 0.815 |
| R-HSA-9733709 | Cardiogenesis | 0.424701 | 0.372 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.092997 | 1.032 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.110778 | 0.956 |
| R-HSA-9675143 | Diseases of the neuronal system | 0.355543 | 0.449 |
| R-HSA-2474795 | Diseases associated with visual transduction | 0.355543 | 0.449 |
| R-HSA-6807070 | PTEN Regulation | 0.379911 | 0.420 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.228049 | 0.642 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.423810 | 0.373 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.212602 | 0.672 |
| R-HSA-166520 | Signaling by NTRKs | 0.417750 | 0.379 |
| R-HSA-186763 | Downstream signal transduction | 0.408137 | 0.389 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.258459 | 0.588 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.153485 | 0.814 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.154466 | 0.811 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.336998 | 0.472 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.095682 | 1.019 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.179885 | 0.745 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.346336 | 0.461 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.364621 | 0.438 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.246190 | 0.609 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.355543 | 0.449 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.355543 | 0.449 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.266187 | 0.575 |
| R-HSA-9607240 | FLT3 Signaling | 0.148589 | 0.828 |
| R-HSA-9749641 | Aspirin ADME | 0.108749 | 0.964 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.355543 | 0.449 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.349067 | 0.457 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.336998 | 0.472 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.176847 | 0.752 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.210930 | 0.676 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.359248 | 0.445 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.379911 | 0.420 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.424701 | 0.372 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.276626 | 0.558 |
| R-HSA-449147 | Signaling by Interleukins | 0.130675 | 0.884 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.414084 | 0.383 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.327527 | 0.485 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.333697 | 0.477 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.394393 | 0.404 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.428642 | 0.368 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.432683 | 0.364 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.432809 | 0.364 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.432809 | 0.364 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.432809 | 0.364 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.432809 | 0.364 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.432809 | 0.364 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.432809 | 0.364 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.432809 | 0.364 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.432809 | 0.364 |
| R-HSA-189483 | Heme degradation | 0.432809 | 0.364 |
| R-HSA-9748784 | Drug ADME | 0.435633 | 0.361 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.438241 | 0.358 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.440803 | 0.356 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.440803 | 0.356 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.440803 | 0.356 |
| R-HSA-5673000 | RAF activation | 0.440803 | 0.356 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.440803 | 0.356 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.447753 | 0.349 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.447753 | 0.349 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.448685 | 0.348 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.448685 | 0.348 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.448685 | 0.348 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.448685 | 0.348 |
| R-HSA-169911 | Regulation of Apoptosis | 0.448685 | 0.348 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.448685 | 0.348 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.452475 | 0.344 |
| R-HSA-72766 | Translation | 0.453977 | 0.343 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.456456 | 0.341 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.456456 | 0.341 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.456456 | 0.341 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.456456 | 0.341 |
| R-HSA-111933 | Calmodulin induced events | 0.456456 | 0.341 |
| R-HSA-111997 | CaM pathway | 0.456456 | 0.341 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.456456 | 0.341 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.457174 | 0.340 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.457174 | 0.340 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.457174 | 0.340 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.457174 | 0.340 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.461850 | 0.335 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.461850 | 0.335 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.464118 | 0.333 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.464118 | 0.333 |
| R-HSA-4641258 | Degradation of DVL | 0.464118 | 0.333 |
| R-HSA-4641257 | Degradation of AXIN | 0.464118 | 0.333 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.464118 | 0.333 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.464118 | 0.333 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.466502 | 0.331 |
| R-HSA-212436 | Generic Transcription Pathway | 0.467788 | 0.330 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.470146 | 0.328 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.471673 | 0.326 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.471673 | 0.326 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.471673 | 0.326 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.475735 | 0.323 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.479122 | 0.320 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.479122 | 0.320 |
| R-HSA-71336 | Pentose phosphate pathway | 0.479122 | 0.320 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.479122 | 0.320 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.479122 | 0.320 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.479122 | 0.320 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.479122 | 0.320 |
| R-HSA-69541 | Stabilization of p53 | 0.479122 | 0.320 |
| R-HSA-201556 | Signaling by ALK | 0.479122 | 0.320 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.486466 | 0.313 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.486466 | 0.313 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.486466 | 0.313 |
| R-HSA-167169 | HIV Transcription Elongation | 0.486466 | 0.313 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.486466 | 0.313 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.486466 | 0.313 |
| R-HSA-202433 | Generation of second messenger molecules | 0.486466 | 0.313 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.486466 | 0.313 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.486466 | 0.313 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.486466 | 0.313 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.486466 | 0.313 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.486466 | 0.313 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.486466 | 0.313 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.493707 | 0.307 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.493707 | 0.307 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.493707 | 0.307 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.493707 | 0.307 |
| R-HSA-9694548 | Maturation of spike protein | 0.493707 | 0.307 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.493707 | 0.307 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.493909 | 0.306 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.500104 | 0.301 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.500846 | 0.300 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.500846 | 0.300 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.500846 | 0.300 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.500846 | 0.300 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.500846 | 0.300 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.500846 | 0.300 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.500846 | 0.300 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.500846 | 0.300 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.500846 | 0.300 |
| R-HSA-69239 | Synthesis of DNA | 0.502845 | 0.299 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.507276 | 0.295 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.507276 | 0.295 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.507886 | 0.294 |
| R-HSA-991365 | Activation of GABAB receptors | 0.507886 | 0.294 |
| R-HSA-977444 | GABA B receptor activation | 0.507886 | 0.294 |
| R-HSA-165159 | MTOR signalling | 0.507886 | 0.294 |
| R-HSA-111996 | Ca-dependent events | 0.507886 | 0.294 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.511680 | 0.291 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.511680 | 0.291 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.514826 | 0.288 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.514826 | 0.288 |
| R-HSA-202403 | TCR signaling | 0.516059 | 0.287 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.516059 | 0.287 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.516059 | 0.287 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.518869 | 0.285 |
| R-HSA-69236 | G1 Phase | 0.521669 | 0.283 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.521669 | 0.283 |
| R-HSA-2172127 | DAP12 interactions | 0.521669 | 0.283 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.521669 | 0.283 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.521669 | 0.283 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.521669 | 0.283 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.528415 | 0.277 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.528415 | 0.277 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.528415 | 0.277 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.528415 | 0.277 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.528415 | 0.277 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.528415 | 0.277 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.528415 | 0.277 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.528415 | 0.277 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.528415 | 0.277 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.528415 | 0.277 |
| R-HSA-9824272 | Somitogenesis | 0.528415 | 0.277 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 0.528415 | 0.277 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.529039 | 0.277 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.535067 | 0.272 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.535067 | 0.272 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.535067 | 0.272 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.535067 | 0.272 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.535067 | 0.272 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.535067 | 0.272 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.535067 | 0.272 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.535067 | 0.272 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.535067 | 0.272 |
| R-HSA-75153 | Apoptotic execution phase | 0.535067 | 0.272 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.535067 | 0.272 |
| R-HSA-2559583 | Cellular Senescence | 0.535940 | 0.271 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.537561 | 0.270 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.541626 | 0.266 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.541626 | 0.266 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.541626 | 0.266 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.541782 | 0.266 |
| R-HSA-74160 | Gene expression (Transcription) | 0.544200 | 0.264 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.545976 | 0.263 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.548092 | 0.261 |
| R-HSA-5620924 | Intraflagellar transport | 0.548092 | 0.261 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.548092 | 0.261 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.554285 | 0.256 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 0.554468 | 0.256 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.554468 | 0.256 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.554468 | 0.256 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.554468 | 0.256 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.560754 | 0.251 |
| R-HSA-109704 | PI3K Cascade | 0.560754 | 0.251 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.562486 | 0.250 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.562486 | 0.250 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.562486 | 0.250 |
| R-HSA-168256 | Immune System | 0.565253 | 0.248 |
| R-HSA-912446 | Meiotic recombination | 0.566952 | 0.246 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.566952 | 0.246 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.566952 | 0.246 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.566952 | 0.246 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.566952 | 0.246 |
| R-HSA-2514856 | The phototransduction cascade | 0.566952 | 0.246 |
| R-HSA-3371556 | Cellular response to heat stress | 0.570579 | 0.244 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.572259 | 0.242 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.573063 | 0.242 |
| R-HSA-72187 | mRNA 3'-end processing | 0.573063 | 0.242 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.573063 | 0.242 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.573063 | 0.242 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.573063 | 0.242 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.573063 | 0.242 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.573063 | 0.242 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.573063 | 0.242 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.574585 | 0.241 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.574585 | 0.241 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.579087 | 0.237 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.579087 | 0.237 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.579087 | 0.237 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.579087 | 0.237 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.579087 | 0.237 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.581856 | 0.235 |
| R-HSA-72649 | Translation initiation complex formation | 0.585028 | 0.233 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.585028 | 0.233 |
| R-HSA-9609690 | HCMV Early Events | 0.588178 | 0.230 |
| R-HSA-69206 | G1/S Transition | 0.590337 | 0.229 |
| R-HSA-194138 | Signaling by VEGF | 0.590337 | 0.229 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.590884 | 0.228 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.590884 | 0.228 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.596659 | 0.224 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.596659 | 0.224 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.596659 | 0.224 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.596659 | 0.224 |
| R-HSA-5578775 | Ion homeostasis | 0.596659 | 0.224 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.596659 | 0.224 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.599660 | 0.222 |
| R-HSA-112399 | IRS-mediated signalling | 0.602352 | 0.220 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.602352 | 0.220 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.607965 | 0.216 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.607965 | 0.216 |
| R-HSA-191859 | snRNP Assembly | 0.613500 | 0.212 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.613500 | 0.212 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.613500 | 0.212 |
| R-HSA-4085001 | Sialic acid metabolism | 0.613500 | 0.212 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.613500 | 0.212 |
| R-HSA-180786 | Extension of Telomeres | 0.613500 | 0.212 |
| R-HSA-72172 | mRNA Splicing | 0.615865 | 0.211 |
| R-HSA-977443 | GABA receptor activation | 0.618956 | 0.208 |
| R-HSA-351202 | Metabolism of polyamines | 0.618956 | 0.208 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.618956 | 0.208 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.618956 | 0.208 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.618956 | 0.208 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.618956 | 0.208 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.618956 | 0.208 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.620533 | 0.207 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.620699 | 0.207 |
| R-HSA-1643685 | Disease | 0.623339 | 0.205 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.624336 | 0.205 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.624336 | 0.205 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.624336 | 0.205 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.624336 | 0.205 |
| R-HSA-450294 | MAP kinase activation | 0.624336 | 0.205 |
| R-HSA-112043 | PLC beta mediated events | 0.624336 | 0.205 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.624336 | 0.205 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.624336 | 0.205 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.629640 | 0.201 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.629640 | 0.201 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.629640 | 0.201 |
| R-HSA-1268020 | Mitochondrial protein import | 0.629640 | 0.201 |
| R-HSA-186797 | Signaling by PDGF | 0.629640 | 0.201 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.634870 | 0.197 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.634870 | 0.197 |
| R-HSA-8848021 | Signaling by PTK6 | 0.634870 | 0.197 |
| R-HSA-373755 | Semaphorin interactions | 0.634870 | 0.197 |
| R-HSA-5663205 | Infectious disease | 0.636491 | 0.196 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.638534 | 0.195 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.640026 | 0.194 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.640026 | 0.194 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.640026 | 0.194 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.645110 | 0.190 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.645110 | 0.190 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.645110 | 0.190 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.650122 | 0.187 |
| R-HSA-1483257 | Phospholipid metabolism | 0.653384 | 0.185 |
| R-HSA-1280218 | Adaptive Immune System | 0.653837 | 0.185 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.655063 | 0.184 |
| R-HSA-112040 | G-protein mediated events | 0.655063 | 0.184 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.655819 | 0.183 |
| R-HSA-167172 | Transcription of the HIV genome | 0.659936 | 0.180 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.659936 | 0.180 |
| R-HSA-5218859 | Regulated Necrosis | 0.659936 | 0.180 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.669475 | 0.174 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.669475 | 0.174 |
| R-HSA-448424 | Interleukin-17 signaling | 0.669475 | 0.174 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.669475 | 0.174 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.669475 | 0.174 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.674145 | 0.171 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.674145 | 0.171 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.674145 | 0.171 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.674145 | 0.171 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.674145 | 0.171 |
| R-HSA-189445 | Metabolism of porphyrins | 0.674145 | 0.171 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.678053 | 0.169 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.678138 | 0.169 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.678749 | 0.168 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.678749 | 0.168 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.678749 | 0.168 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.678749 | 0.168 |
| R-HSA-74259 | Purine catabolism | 0.678749 | 0.168 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.678945 | 0.168 |
| R-HSA-913531 | Interferon Signaling | 0.678945 | 0.168 |
| R-HSA-2187338 | Visual phototransduction | 0.678964 | 0.168 |
| R-HSA-69242 | S Phase | 0.682163 | 0.166 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.682163 | 0.166 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.683288 | 0.165 |
| R-HSA-4086398 | Ca2+ pathway | 0.683288 | 0.165 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.683288 | 0.165 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.683414 | 0.165 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.687763 | 0.163 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.687763 | 0.163 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.687763 | 0.163 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.687763 | 0.163 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.692175 | 0.160 |
| R-HSA-917937 | Iron uptake and transport | 0.692175 | 0.160 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.692175 | 0.160 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.696525 | 0.157 |
| R-HSA-5689603 | UCH proteinases | 0.696525 | 0.157 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.696525 | 0.157 |
| R-HSA-69306 | DNA Replication | 0.697769 | 0.156 |
| R-HSA-9609507 | Protein localization | 0.697769 | 0.156 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.698856 | 0.156 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.700814 | 0.154 |
| R-HSA-1989781 | PPARA activates gene expression | 0.703832 | 0.153 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.705043 | 0.152 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.705043 | 0.152 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.705043 | 0.152 |
| R-HSA-5619084 | ABC transporter disorders | 0.705043 | 0.152 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.706361 | 0.151 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.709212 | 0.149 |
| R-HSA-9659379 | Sensory processing of sound | 0.709212 | 0.149 |
| R-HSA-9610379 | HCMV Late Events | 0.709794 | 0.149 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.709794 | 0.149 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.712737 | 0.147 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.713322 | 0.147 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.713322 | 0.147 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.721370 | 0.142 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.721370 | 0.142 |
| R-HSA-109581 | Apoptosis | 0.724263 | 0.140 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.725309 | 0.139 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.729193 | 0.137 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.730349 | 0.136 |
| R-HSA-1500620 | Meiosis | 0.733022 | 0.135 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.733022 | 0.135 |
| R-HSA-1474244 | Extracellular matrix organization | 0.733785 | 0.134 |
| R-HSA-4839726 | Chromatin organization | 0.734959 | 0.134 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.736798 | 0.133 |
| R-HSA-9609646 | HCMV Infection | 0.737240 | 0.132 |
| R-HSA-5619102 | SLC transporter disorders | 0.738120 | 0.132 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.740520 | 0.130 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.740520 | 0.130 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.744189 | 0.128 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.744189 | 0.128 |
| R-HSA-5688426 | Deubiquitination | 0.748417 | 0.126 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.751382 | 0.124 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.753605 | 0.123 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.754891 | 0.122 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.756523 | 0.121 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.756523 | 0.121 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.756523 | 0.121 |
| R-HSA-391251 | Protein folding | 0.765147 | 0.116 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.765147 | 0.116 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.765508 | 0.116 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.768394 | 0.114 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.768470 | 0.114 |
| R-HSA-1474290 | Collagen formation | 0.771746 | 0.113 |
| R-HSA-1296071 | Potassium Channels | 0.781300 | 0.107 |
| R-HSA-157579 | Telomere Maintenance | 0.784395 | 0.105 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.784395 | 0.105 |
| R-HSA-422356 | Regulation of insulin secretion | 0.787447 | 0.104 |
| R-HSA-3214847 | HATs acetylate histones | 0.790455 | 0.102 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.792816 | 0.101 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.793421 | 0.100 |
| R-HSA-70171 | Glycolysis | 0.793421 | 0.100 |
| R-HSA-446728 | Cell junction organization | 0.795014 | 0.100 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.799229 | 0.097 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.799229 | 0.097 |
| R-HSA-9658195 | Leishmania infection | 0.800531 | 0.097 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.800531 | 0.097 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.800949 | 0.096 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.803027 | 0.095 |
| R-HSA-168249 | Innate Immune System | 0.803969 | 0.095 |
| R-HSA-111885 | Opioid Signalling | 0.804874 | 0.094 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.807637 | 0.093 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.807637 | 0.093 |
| R-HSA-9833110 | RSV-host interactions | 0.807637 | 0.093 |
| R-HSA-109582 | Hemostasis | 0.808321 | 0.092 |
| R-HSA-6798695 | Neutrophil degranulation | 0.808946 | 0.092 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.809338 | 0.092 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.813047 | 0.090 |
| R-HSA-211000 | Gene Silencing by RNA | 0.815694 | 0.088 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.817411 | 0.088 |
| R-HSA-597592 | Post-translational protein modification | 0.822667 | 0.085 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.828383 | 0.082 |
| R-HSA-5357801 | Programmed Cell Death | 0.828950 | 0.081 |
| R-HSA-195721 | Signaling by WNT | 0.829498 | 0.081 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.837905 | 0.077 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.841582 | 0.075 |
| R-HSA-397014 | Muscle contraction | 0.841582 | 0.075 |
| R-HSA-70326 | Glucose metabolism | 0.844700 | 0.073 |
| R-HSA-382551 | Transport of small molecules | 0.844776 | 0.073 |
| R-HSA-418990 | Adherens junctions interactions | 0.851732 | 0.070 |
| R-HSA-73886 | Chromosome Maintenance | 0.853320 | 0.069 |
| R-HSA-1500931 | Cell-Cell communication | 0.856181 | 0.067 |
| R-HSA-8951664 | Neddylation | 0.856583 | 0.067 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.863428 | 0.064 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.863428 | 0.064 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.863428 | 0.064 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.865534 | 0.063 |
| R-HSA-114608 | Platelet degranulation | 0.867275 | 0.062 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.870282 | 0.060 |
| R-HSA-8956319 | Nucleotide catabolism | 0.871013 | 0.060 |
| R-HSA-1474165 | Reproduction | 0.874647 | 0.058 |
| R-HSA-5576891 | Cardiac conduction | 0.876425 | 0.057 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.876425 | 0.057 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.879907 | 0.056 |
| R-HSA-157118 | Signaling by NOTCH | 0.884091 | 0.054 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.886580 | 0.052 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.888190 | 0.051 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.889777 | 0.051 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.892884 | 0.049 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.892884 | 0.049 |
| R-HSA-9664407 | Parasite infection | 0.892884 | 0.049 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.894405 | 0.048 |
| R-HSA-421270 | Cell-cell junction organization | 0.897707 | 0.047 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.900276 | 0.046 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.903392 | 0.044 |
| R-HSA-9758941 | Gastrulation | 0.907160 | 0.042 |
| R-HSA-416476 | G alpha (q) signalling events | 0.911881 | 0.040 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.913570 | 0.039 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.917203 | 0.038 |
| R-HSA-112316 | Neuronal System | 0.917424 | 0.037 |
| R-HSA-877300 | Interferon gamma signaling | 0.919540 | 0.036 |
| R-HSA-418555 | G alpha (s) signalling events | 0.933208 | 0.030 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.934159 | 0.030 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.935095 | 0.029 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.935095 | 0.029 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.936019 | 0.029 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.936929 | 0.028 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.943763 | 0.025 |
| R-HSA-3781865 | Diseases of glycosylation | 0.944564 | 0.025 |
| R-HSA-983712 | Ion channel transport | 0.948400 | 0.023 |
| R-HSA-211859 | Biological oxidations | 0.950994 | 0.022 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.951277 | 0.022 |
| R-HSA-392499 | Metabolism of proteins | 0.954580 | 0.020 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.955998 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 0.956522 | 0.019 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.957791 | 0.019 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.957791 | 0.019 |
| R-HSA-9679506 | SARS-CoV Infections | 0.964243 | 0.016 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.965847 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.973228 | 0.012 |
| R-HSA-15869 | Metabolism of nucleotides | 0.974107 | 0.011 |
| R-HSA-8939211 | ESR-mediated signaling | 0.974477 | 0.011 |
| R-HSA-1266738 | Developmental Biology | 0.975786 | 0.011 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.982400 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.988815 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 0.995264 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.997246 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997402 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.997849 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997849 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.998392 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998503 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999814 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999998 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.896 | 0.199 | 2 | 0.871 |
CDC7 |
0.882 | 0.049 | 1 | 0.854 |
CLK3 |
0.881 | 0.188 | 1 | 0.849 |
PRPK |
0.879 | -0.086 | -1 | 0.901 |
PIM3 |
0.877 | 0.062 | -3 | 0.820 |
NLK |
0.877 | 0.094 | 1 | 0.843 |
MOS |
0.876 | 0.024 | 1 | 0.869 |
MTOR |
0.876 | -0.036 | 1 | 0.815 |
GCN2 |
0.876 | -0.103 | 2 | 0.822 |
NEK6 |
0.875 | 0.082 | -2 | 0.878 |
ULK2 |
0.875 | -0.054 | 2 | 0.815 |
TBK1 |
0.874 | -0.012 | 1 | 0.758 |
DSTYK |
0.874 | 0.021 | 2 | 0.877 |
RAF1 |
0.873 | -0.064 | 1 | 0.858 |
BMPR2 |
0.873 | -0.052 | -2 | 0.888 |
ATR |
0.872 | 0.070 | 1 | 0.877 |
IKKB |
0.872 | -0.093 | -2 | 0.755 |
PRKD1 |
0.872 | 0.080 | -3 | 0.808 |
CDKL1 |
0.872 | 0.043 | -3 | 0.768 |
CAMK1B |
0.872 | -0.026 | -3 | 0.834 |
ERK5 |
0.872 | 0.068 | 1 | 0.799 |
RSK2 |
0.871 | 0.058 | -3 | 0.747 |
IKKE |
0.871 | -0.033 | 1 | 0.756 |
NDR2 |
0.871 | 0.002 | -3 | 0.837 |
CAMK2G |
0.870 | -0.068 | 2 | 0.806 |
PDHK4 |
0.870 | -0.277 | 1 | 0.870 |
NEK7 |
0.869 | -0.034 | -3 | 0.833 |
TGFBR2 |
0.869 | 0.035 | -2 | 0.803 |
PRKD2 |
0.869 | 0.080 | -3 | 0.756 |
NUAK2 |
0.868 | 0.040 | -3 | 0.816 |
PKN3 |
0.868 | 0.004 | -3 | 0.797 |
CDKL5 |
0.867 | 0.058 | -3 | 0.763 |
WNK1 |
0.867 | 0.026 | -2 | 0.844 |
CHAK2 |
0.867 | 0.029 | -1 | 0.867 |
HIPK4 |
0.867 | 0.085 | 1 | 0.803 |
MLK1 |
0.867 | -0.029 | 2 | 0.839 |
NIK |
0.867 | -0.013 | -3 | 0.860 |
MST4 |
0.867 | 0.054 | 2 | 0.861 |
PIM1 |
0.866 | 0.076 | -3 | 0.760 |
PDHK1 |
0.866 | -0.200 | 1 | 0.855 |
PKCD |
0.866 | 0.088 | 2 | 0.826 |
SKMLCK |
0.866 | 0.028 | -2 | 0.810 |
AMPKA1 |
0.866 | 0.062 | -3 | 0.838 |
MAPKAPK3 |
0.865 | 0.019 | -3 | 0.761 |
P90RSK |
0.865 | 0.016 | -3 | 0.746 |
RIPK3 |
0.865 | -0.040 | 3 | 0.756 |
GRK5 |
0.864 | -0.134 | -3 | 0.838 |
IKKA |
0.864 | -0.004 | -2 | 0.754 |
SRPK1 |
0.864 | 0.061 | -3 | 0.715 |
MARK4 |
0.864 | 0.041 | 4 | 0.844 |
PKN2 |
0.864 | 0.018 | -3 | 0.811 |
KIS |
0.864 | 0.065 | 1 | 0.698 |
ULK1 |
0.863 | -0.130 | -3 | 0.803 |
NDR1 |
0.863 | -0.030 | -3 | 0.820 |
TSSK2 |
0.863 | 0.062 | -5 | 0.861 |
NEK9 |
0.863 | -0.036 | 2 | 0.860 |
CAMLCK |
0.863 | -0.041 | -2 | 0.816 |
MLK3 |
0.862 | 0.071 | 2 | 0.785 |
MAPKAPK2 |
0.862 | 0.037 | -3 | 0.717 |
DAPK2 |
0.862 | -0.029 | -3 | 0.842 |
LATS2 |
0.861 | -0.010 | -5 | 0.746 |
TSSK1 |
0.861 | 0.084 | -3 | 0.860 |
RSK3 |
0.861 | -0.008 | -3 | 0.734 |
GRK6 |
0.861 | -0.017 | 1 | 0.849 |
ICK |
0.861 | 0.037 | -3 | 0.810 |
CAMK2D |
0.861 | -0.036 | -3 | 0.820 |
MLK2 |
0.861 | -0.016 | 2 | 0.841 |
GRK1 |
0.861 | 0.024 | -2 | 0.743 |
CDK8 |
0.860 | 0.045 | 1 | 0.681 |
PLK1 |
0.860 | 0.068 | -2 | 0.848 |
AMPKA2 |
0.860 | 0.050 | -3 | 0.806 |
WNK3 |
0.859 | -0.157 | 1 | 0.835 |
NIM1 |
0.859 | 0.002 | 3 | 0.778 |
P70S6KB |
0.859 | -0.013 | -3 | 0.770 |
BMPR1B |
0.858 | 0.123 | 1 | 0.807 |
IRE1 |
0.857 | -0.024 | 1 | 0.807 |
ALK4 |
0.857 | 0.047 | -2 | 0.826 |
SRPK2 |
0.857 | 0.054 | -3 | 0.636 |
HUNK |
0.857 | -0.164 | 2 | 0.811 |
ANKRD3 |
0.857 | -0.084 | 1 | 0.865 |
TGFBR1 |
0.857 | 0.070 | -2 | 0.800 |
BCKDK |
0.856 | -0.173 | -1 | 0.835 |
PKR |
0.856 | 0.060 | 1 | 0.851 |
IRE2 |
0.856 | 0.031 | 2 | 0.807 |
LATS1 |
0.856 | 0.079 | -3 | 0.856 |
CAMK2B |
0.856 | 0.025 | 2 | 0.758 |
DLK |
0.856 | -0.160 | 1 | 0.847 |
ATM |
0.856 | 0.050 | 1 | 0.827 |
MELK |
0.856 | 0.025 | -3 | 0.787 |
MASTL |
0.856 | -0.270 | -2 | 0.814 |
NUAK1 |
0.855 | 0.021 | -3 | 0.769 |
CDK19 |
0.855 | 0.052 | 1 | 0.643 |
PKACG |
0.855 | -0.034 | -2 | 0.690 |
PKCB |
0.854 | 0.061 | 2 | 0.785 |
AURC |
0.854 | 0.021 | -2 | 0.596 |
MNK2 |
0.854 | 0.018 | -2 | 0.755 |
CDK5 |
0.854 | 0.102 | 1 | 0.706 |
FAM20C |
0.854 | 0.024 | 2 | 0.564 |
CDK7 |
0.853 | 0.036 | 1 | 0.686 |
PKCA |
0.853 | 0.058 | 2 | 0.778 |
CDK1 |
0.853 | 0.090 | 1 | 0.649 |
GRK7 |
0.852 | 0.060 | 1 | 0.788 |
CDK18 |
0.852 | 0.093 | 1 | 0.622 |
PRKD3 |
0.852 | 0.006 | -3 | 0.708 |
PAK1 |
0.852 | -0.041 | -2 | 0.734 |
JNK2 |
0.852 | 0.102 | 1 | 0.630 |
DNAPK |
0.851 | 0.120 | 1 | 0.782 |
GRK4 |
0.851 | -0.165 | -2 | 0.795 |
TTBK2 |
0.851 | -0.184 | 2 | 0.736 |
MLK4 |
0.851 | -0.017 | 2 | 0.755 |
NEK2 |
0.851 | -0.025 | 2 | 0.844 |
CAMK4 |
0.851 | -0.106 | -3 | 0.797 |
YSK4 |
0.851 | -0.057 | 1 | 0.797 |
PKCG |
0.851 | 0.016 | 2 | 0.783 |
CAMK2A |
0.851 | -0.000 | 2 | 0.777 |
ACVR2A |
0.851 | 0.051 | -2 | 0.807 |
DYRK2 |
0.851 | 0.044 | 1 | 0.708 |
SRPK3 |
0.851 | 0.016 | -3 | 0.679 |
PAK3 |
0.850 | -0.076 | -2 | 0.739 |
SMG1 |
0.850 | 0.046 | 1 | 0.839 |
P38A |
0.850 | 0.084 | 1 | 0.710 |
ACVR2B |
0.850 | 0.049 | -2 | 0.815 |
RSK4 |
0.850 | 0.026 | -3 | 0.721 |
VRK2 |
0.849 | -0.096 | 1 | 0.879 |
RIPK1 |
0.849 | -0.218 | 1 | 0.831 |
CLK1 |
0.849 | 0.063 | -3 | 0.711 |
PHKG1 |
0.849 | -0.037 | -3 | 0.809 |
PAK6 |
0.849 | 0.034 | -2 | 0.666 |
CLK4 |
0.849 | 0.028 | -3 | 0.734 |
JNK3 |
0.849 | 0.069 | 1 | 0.666 |
QIK |
0.849 | -0.060 | -3 | 0.809 |
MNK1 |
0.849 | 0.012 | -2 | 0.763 |
QSK |
0.848 | 0.020 | 4 | 0.823 |
P38B |
0.848 | 0.094 | 1 | 0.639 |
CHK1 |
0.848 | -0.011 | -3 | 0.827 |
PLK3 |
0.848 | -0.034 | 2 | 0.763 |
PKCH |
0.847 | -0.008 | 2 | 0.776 |
CHAK1 |
0.847 | -0.081 | 2 | 0.796 |
TLK2 |
0.847 | -0.021 | 1 | 0.820 |
MEK1 |
0.847 | -0.191 | 2 | 0.840 |
CDK2 |
0.846 | 0.056 | 1 | 0.730 |
ALK2 |
0.846 | 0.026 | -2 | 0.802 |
ERK1 |
0.846 | 0.069 | 1 | 0.631 |
PKCZ |
0.846 | -0.025 | 2 | 0.816 |
CDK13 |
0.846 | 0.005 | 1 | 0.662 |
MSK2 |
0.846 | -0.090 | -3 | 0.708 |
PKG2 |
0.845 | 0.004 | -2 | 0.622 |
SIK |
0.845 | -0.010 | -3 | 0.736 |
PLK4 |
0.845 | -0.033 | 2 | 0.678 |
SGK3 |
0.845 | 0.019 | -3 | 0.735 |
AURB |
0.845 | -0.019 | -2 | 0.596 |
PIM2 |
0.845 | 0.030 | -3 | 0.716 |
PKACB |
0.844 | 0.012 | -2 | 0.620 |
CDK3 |
0.844 | 0.127 | 1 | 0.586 |
CDK17 |
0.844 | 0.059 | 1 | 0.568 |
P38G |
0.844 | 0.068 | 1 | 0.561 |
MARK3 |
0.844 | 0.042 | 4 | 0.792 |
ERK2 |
0.844 | 0.032 | 1 | 0.687 |
PERK |
0.844 | -0.064 | -2 | 0.841 |
BRSK1 |
0.843 | -0.054 | -3 | 0.766 |
MARK2 |
0.843 | 0.023 | 4 | 0.748 |
MSK1 |
0.843 | -0.039 | -3 | 0.717 |
HRI |
0.843 | -0.089 | -2 | 0.859 |
PRP4 |
0.843 | 0.056 | -3 | 0.754 |
PAK2 |
0.842 | -0.099 | -2 | 0.719 |
NEK5 |
0.842 | 0.016 | 1 | 0.847 |
CLK2 |
0.842 | 0.083 | -3 | 0.722 |
CDK16 |
0.842 | 0.116 | 1 | 0.588 |
HIPK1 |
0.842 | 0.054 | 1 | 0.728 |
BRSK2 |
0.842 | -0.080 | -3 | 0.795 |
DCAMKL1 |
0.841 | -0.011 | -3 | 0.767 |
IRAK4 |
0.841 | -0.017 | 1 | 0.819 |
AKT2 |
0.841 | -0.000 | -3 | 0.653 |
HIPK2 |
0.840 | 0.063 | 1 | 0.622 |
MYLK4 |
0.840 | -0.069 | -2 | 0.712 |
BMPR1A |
0.840 | 0.075 | 1 | 0.785 |
BRAF |
0.840 | -0.081 | -4 | 0.846 |
ZAK |
0.839 | -0.097 | 1 | 0.801 |
MST3 |
0.839 | 0.038 | 2 | 0.851 |
CDK14 |
0.839 | 0.066 | 1 | 0.668 |
DYRK1A |
0.838 | 0.023 | 1 | 0.747 |
DRAK1 |
0.838 | -0.092 | 1 | 0.792 |
PRKX |
0.838 | 0.032 | -3 | 0.662 |
MEKK1 |
0.838 | -0.126 | 1 | 0.821 |
MEKK2 |
0.838 | -0.072 | 2 | 0.828 |
SNRK |
0.837 | -0.185 | 2 | 0.727 |
CDK12 |
0.837 | -0.003 | 1 | 0.634 |
WNK4 |
0.837 | -0.096 | -2 | 0.844 |
MPSK1 |
0.837 | 0.083 | 1 | 0.794 |
MARK1 |
0.837 | -0.023 | 4 | 0.804 |
CAMK1G |
0.837 | -0.067 | -3 | 0.725 |
P38D |
0.836 | 0.087 | 1 | 0.584 |
TAO3 |
0.836 | -0.002 | 1 | 0.813 |
AURA |
0.836 | -0.054 | -2 | 0.566 |
CDK9 |
0.836 | -0.027 | 1 | 0.670 |
GRK2 |
0.836 | -0.097 | -2 | 0.682 |
DCAMKL2 |
0.835 | -0.039 | -3 | 0.789 |
SSTK |
0.835 | 0.018 | 4 | 0.799 |
MEK5 |
0.835 | -0.267 | 2 | 0.838 |
MAPKAPK5 |
0.835 | -0.157 | -3 | 0.680 |
PHKG2 |
0.835 | -0.037 | -3 | 0.768 |
TLK1 |
0.835 | -0.094 | -2 | 0.825 |
PKCT |
0.835 | -0.024 | 2 | 0.783 |
MEKK3 |
0.835 | -0.196 | 1 | 0.814 |
GSK3A |
0.835 | 0.048 | 4 | 0.475 |
GSK3B |
0.834 | 0.003 | 4 | 0.465 |
PINK1 |
0.833 | -0.190 | 1 | 0.836 |
HIPK3 |
0.833 | 0.003 | 1 | 0.717 |
ERK7 |
0.832 | 0.049 | 2 | 0.568 |
AKT1 |
0.832 | 0.003 | -3 | 0.678 |
SMMLCK |
0.831 | -0.083 | -3 | 0.782 |
GAK |
0.831 | 0.035 | 1 | 0.861 |
CAMKK1 |
0.831 | -0.087 | -2 | 0.782 |
CDK10 |
0.831 | 0.059 | 1 | 0.652 |
TAO2 |
0.831 | -0.034 | 2 | 0.877 |
P70S6K |
0.831 | -0.061 | -3 | 0.671 |
DYRK4 |
0.830 | 0.025 | 1 | 0.634 |
PASK |
0.830 | -0.054 | -3 | 0.832 |
CK1E |
0.830 | -0.073 | -3 | 0.521 |
NEK8 |
0.830 | -0.106 | 2 | 0.848 |
EEF2K |
0.829 | 0.032 | 3 | 0.842 |
PKACA |
0.829 | -0.017 | -2 | 0.567 |
NEK4 |
0.829 | -0.007 | 1 | 0.813 |
TNIK |
0.828 | 0.088 | 3 | 0.873 |
DYRK1B |
0.828 | 0.006 | 1 | 0.665 |
LKB1 |
0.828 | -0.032 | -3 | 0.825 |
PKCI |
0.828 | -0.044 | 2 | 0.784 |
NEK11 |
0.828 | -0.149 | 1 | 0.809 |
CAMK1D |
0.827 | -0.040 | -3 | 0.661 |
HGK |
0.827 | 0.023 | 3 | 0.867 |
PKCE |
0.827 | 0.021 | 2 | 0.772 |
GCK |
0.827 | 0.027 | 1 | 0.821 |
TTBK1 |
0.827 | -0.184 | 2 | 0.654 |
DYRK3 |
0.827 | -0.009 | 1 | 0.727 |
NEK1 |
0.826 | 0.036 | 1 | 0.819 |
CAMKK2 |
0.825 | -0.100 | -2 | 0.774 |
MINK |
0.825 | 0.016 | 1 | 0.814 |
CDK6 |
0.825 | 0.054 | 1 | 0.645 |
MST2 |
0.825 | -0.046 | 1 | 0.821 |
BUB1 |
0.825 | 0.126 | -5 | 0.811 |
JNK1 |
0.824 | 0.029 | 1 | 0.622 |
MAP3K15 |
0.824 | -0.047 | 1 | 0.786 |
PDK1 |
0.824 | -0.107 | 1 | 0.806 |
MEKK6 |
0.824 | -0.060 | 1 | 0.813 |
CK2A2 |
0.824 | 0.039 | 1 | 0.708 |
DAPK3 |
0.824 | -0.028 | -3 | 0.774 |
PAK5 |
0.823 | -0.068 | -2 | 0.593 |
IRAK1 |
0.823 | -0.257 | -1 | 0.809 |
PKN1 |
0.823 | -0.028 | -3 | 0.689 |
MAK |
0.823 | 0.111 | -2 | 0.730 |
LOK |
0.823 | -0.008 | -2 | 0.768 |
CK1G1 |
0.822 | -0.091 | -3 | 0.517 |
CDK4 |
0.822 | 0.034 | 1 | 0.624 |
TAK1 |
0.821 | -0.068 | 1 | 0.840 |
PAK4 |
0.821 | -0.056 | -2 | 0.597 |
VRK1 |
0.821 | -0.073 | 2 | 0.854 |
CK1D |
0.821 | -0.076 | -3 | 0.472 |
LRRK2 |
0.821 | -0.124 | 2 | 0.868 |
MST1 |
0.820 | -0.024 | 1 | 0.808 |
HPK1 |
0.819 | -0.008 | 1 | 0.810 |
PLK2 |
0.819 | -0.030 | -3 | 0.766 |
MRCKA |
0.819 | 0.014 | -3 | 0.730 |
KHS1 |
0.819 | 0.061 | 1 | 0.803 |
GRK3 |
0.819 | -0.112 | -2 | 0.626 |
ROCK2 |
0.818 | 0.032 | -3 | 0.767 |
CHK2 |
0.818 | -0.041 | -3 | 0.597 |
SGK1 |
0.818 | -0.002 | -3 | 0.574 |
MOK |
0.818 | 0.064 | 1 | 0.738 |
KHS2 |
0.818 | 0.076 | 1 | 0.819 |
AKT3 |
0.817 | -0.005 | -3 | 0.592 |
MRCKB |
0.817 | -0.007 | -3 | 0.706 |
CK1A2 |
0.816 | -0.084 | -3 | 0.467 |
DAPK1 |
0.815 | -0.056 | -3 | 0.747 |
PDHK3_TYR |
0.815 | 0.259 | 4 | 0.891 |
CAMK1A |
0.815 | -0.034 | -3 | 0.618 |
YSK1 |
0.814 | -0.052 | 2 | 0.836 |
SLK |
0.814 | -0.073 | -2 | 0.711 |
TTK |
0.814 | 0.073 | -2 | 0.835 |
CK2A1 |
0.813 | 0.014 | 1 | 0.690 |
PBK |
0.812 | 0.012 | 1 | 0.776 |
STK33 |
0.812 | -0.179 | 2 | 0.640 |
MEK2 |
0.811 | -0.239 | 2 | 0.827 |
DMPK1 |
0.809 | 0.025 | -3 | 0.730 |
SBK |
0.808 | -0.032 | -3 | 0.536 |
NEK3 |
0.807 | -0.139 | 1 | 0.774 |
OSR1 |
0.807 | -0.051 | 2 | 0.810 |
BIKE |
0.807 | 0.069 | 1 | 0.742 |
RIPK2 |
0.806 | -0.300 | 1 | 0.747 |
MYO3B |
0.805 | 0.007 | 2 | 0.857 |
ROCK1 |
0.804 | -0.002 | -3 | 0.725 |
TESK1_TYR |
0.804 | -0.032 | 3 | 0.887 |
PDHK4_TYR |
0.803 | 0.036 | 2 | 0.862 |
HASPIN |
0.802 | -0.027 | -1 | 0.700 |
ASK1 |
0.802 | -0.104 | 1 | 0.775 |
CRIK |
0.802 | -0.012 | -3 | 0.680 |
LIMK2_TYR |
0.802 | 0.062 | -3 | 0.886 |
PKG1 |
0.801 | -0.078 | -2 | 0.541 |
MYO3A |
0.801 | -0.020 | 1 | 0.802 |
MAP2K4_TYR |
0.801 | -0.112 | -1 | 0.917 |
PKMYT1_TYR |
0.800 | -0.072 | 3 | 0.858 |
MAP2K6_TYR |
0.800 | -0.083 | -1 | 0.916 |
TAO1 |
0.799 | -0.068 | 1 | 0.743 |
MAP2K7_TYR |
0.799 | -0.223 | 2 | 0.863 |
PDHK1_TYR |
0.796 | -0.104 | -1 | 0.932 |
PINK1_TYR |
0.796 | -0.197 | 1 | 0.851 |
BMPR2_TYR |
0.796 | -0.082 | -1 | 0.890 |
ALPHAK3 |
0.795 | -0.101 | -1 | 0.809 |
RET |
0.794 | -0.078 | 1 | 0.822 |
AAK1 |
0.793 | 0.118 | 1 | 0.640 |
EPHA6 |
0.792 | -0.005 | -1 | 0.886 |
TYK2 |
0.792 | -0.092 | 1 | 0.818 |
ROS1 |
0.792 | -0.018 | 3 | 0.765 |
TYRO3 |
0.792 | -0.046 | 3 | 0.794 |
LIMK1_TYR |
0.791 | -0.162 | 2 | 0.872 |
ABL2 |
0.791 | 0.031 | -1 | 0.879 |
EPHB4 |
0.791 | -0.012 | -1 | 0.879 |
JAK2 |
0.791 | -0.064 | 1 | 0.815 |
CSF1R |
0.791 | -0.035 | 3 | 0.795 |
MST1R |
0.790 | -0.112 | 3 | 0.808 |
YES1 |
0.789 | 0.008 | -1 | 0.918 |
ABL1 |
0.788 | 0.015 | -1 | 0.879 |
TXK |
0.788 | 0.075 | 1 | 0.831 |
YANK3 |
0.787 | -0.123 | 2 | 0.408 |
FGR |
0.786 | -0.071 | 1 | 0.849 |
STLK3 |
0.785 | -0.211 | 1 | 0.763 |
DDR1 |
0.785 | -0.184 | 4 | 0.802 |
HCK |
0.784 | -0.024 | -1 | 0.890 |
TNK2 |
0.784 | -0.037 | 3 | 0.756 |
FER |
0.783 | -0.118 | 1 | 0.865 |
JAK1 |
0.783 | 0.008 | 1 | 0.765 |
JAK3 |
0.783 | -0.132 | 1 | 0.806 |
SRMS |
0.782 | -0.057 | 1 | 0.847 |
LCK |
0.782 | 0.020 | -1 | 0.888 |
INSRR |
0.782 | -0.104 | 3 | 0.740 |
PDGFRB |
0.782 | -0.125 | 3 | 0.800 |
NEK10_TYR |
0.782 | -0.068 | 1 | 0.721 |
ITK |
0.782 | -0.038 | -1 | 0.863 |
TNK1 |
0.781 | -0.055 | 3 | 0.776 |
BLK |
0.781 | 0.047 | -1 | 0.895 |
CK1A |
0.781 | -0.113 | -3 | 0.382 |
EPHA4 |
0.780 | -0.079 | 2 | 0.751 |
EPHB1 |
0.780 | -0.081 | 1 | 0.838 |
TNNI3K_TYR |
0.780 | -0.019 | 1 | 0.804 |
MERTK |
0.780 | -0.033 | 3 | 0.775 |
KDR |
0.779 | -0.087 | 3 | 0.761 |
AXL |
0.779 | -0.074 | 3 | 0.772 |
FLT3 |
0.779 | -0.123 | 3 | 0.791 |
KIT |
0.779 | -0.130 | 3 | 0.796 |
FGFR2 |
0.778 | -0.169 | 3 | 0.793 |
EPHB3 |
0.778 | -0.087 | -1 | 0.864 |
EPHB2 |
0.777 | -0.058 | -1 | 0.865 |
TEK |
0.776 | -0.131 | 3 | 0.729 |
TEC |
0.776 | -0.033 | -1 | 0.814 |
PDGFRA |
0.776 | -0.165 | 3 | 0.799 |
FGFR1 |
0.774 | -0.178 | 3 | 0.759 |
PTK6 |
0.773 | -0.151 | -1 | 0.798 |
BTK |
0.773 | -0.152 | -1 | 0.836 |
BMX |
0.773 | -0.058 | -1 | 0.779 |
ALK |
0.773 | -0.119 | 3 | 0.705 |
FYN |
0.772 | -0.006 | -1 | 0.859 |
LTK |
0.772 | -0.116 | 3 | 0.737 |
WEE1_TYR |
0.772 | -0.107 | -1 | 0.792 |
MET |
0.771 | -0.153 | 3 | 0.780 |
PTK2B |
0.771 | -0.010 | -1 | 0.858 |
FRK |
0.770 | -0.075 | -1 | 0.898 |
EPHA7 |
0.769 | -0.097 | 2 | 0.767 |
EPHA1 |
0.769 | -0.100 | 3 | 0.756 |
NTRK1 |
0.768 | -0.219 | -1 | 0.861 |
FLT1 |
0.768 | -0.168 | -1 | 0.859 |
LYN |
0.768 | -0.081 | 3 | 0.716 |
EPHA3 |
0.767 | -0.167 | 2 | 0.738 |
NTRK2 |
0.766 | -0.209 | 3 | 0.751 |
FGFR3 |
0.766 | -0.192 | 3 | 0.765 |
DDR2 |
0.765 | -0.080 | 3 | 0.730 |
FLT4 |
0.765 | -0.202 | 3 | 0.759 |
INSR |
0.765 | -0.184 | 3 | 0.717 |
ERBB2 |
0.765 | -0.221 | 1 | 0.782 |
MATK |
0.762 | -0.142 | -1 | 0.804 |
CK1G3 |
0.762 | -0.106 | -3 | 0.333 |
NTRK3 |
0.762 | -0.182 | -1 | 0.811 |
SRC |
0.761 | -0.092 | -1 | 0.874 |
EPHA5 |
0.761 | -0.124 | 2 | 0.740 |
EGFR |
0.758 | -0.132 | 1 | 0.691 |
CSK |
0.758 | -0.187 | 2 | 0.773 |
EPHA8 |
0.757 | -0.149 | -1 | 0.842 |
YANK2 |
0.755 | -0.151 | 2 | 0.422 |
MUSK |
0.754 | -0.149 | 1 | 0.678 |
PTK2 |
0.753 | -0.074 | -1 | 0.787 |
FGFR4 |
0.753 | -0.166 | -1 | 0.824 |
EPHA2 |
0.749 | -0.139 | -1 | 0.801 |
SYK |
0.749 | -0.105 | -1 | 0.787 |
IGF1R |
0.747 | -0.198 | 3 | 0.654 |
ERBB4 |
0.741 | -0.145 | 1 | 0.706 |
CK1G2 |
0.736 | -0.148 | -3 | 0.430 |
FES |
0.736 | -0.177 | -1 | 0.765 |
ZAP70 |
0.725 | -0.138 | -1 | 0.713 |