Motif 938 (n=107)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0C4DFX4 | None | S2995 | ochoa | Snf2 related CREBBP activator protein | None |
A6NKD9 | CCDC85C | S258 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
B2RTY4 | MYO9A | S40 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
O00192 | ARVCF | S916 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
O00429 | DNM1L | S637 | psp | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
O14920 | IKBKB | S692 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
O15027 | SEC16A | S1810 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
O43399 | TPD52L2 | S166 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
O60292 | SIPA1L3 | S207 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O75665 | OFD1 | S745 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
O94906 | PRPF6 | S261 | ochoa | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}. |
O94916 | NFAT5 | S248 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
P01106 | MYC | S388 | psp | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}. |
P02671 | FGA | S22 | psp | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
P04049 | RAF1 | S624 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
P11137 | MAP2 | S738 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P15924 | DSP | S246 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
P26045 | PTPN3 | S489 | ochoa | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
P29375 | KDM5A | S225 | ochoa|psp | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
P39748 | FEN1 | S351 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
P41236 | PPP1R2 | S122 | ochoa|psp | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
P42858 | HTT | S2934 | ochoa | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
P49685 | GPR15 | S328 | ochoa | G-protein coupled receptor 15 (Brother of Bonzo) (BoB) | G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660). {ECO:0000250|UniProtKB:Q0VDU3, ECO:0000269|PubMed:33758080, ECO:0000269|PubMed:35510660, ECO:0000269|PubMed:38918398}.; FUNCTION: (Microbial infection) Acts as an alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9791028}. |
P49810 | PSEN2 | S330 | psp | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}. |
P49815 | TSC2 | S932 | psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
P50402 | EMD | S87 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
P52565 | ARHGDIA | S101 | ochoa|psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
P78337 | PITX1 | S46 | ochoa | Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) | Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}. |
Q04917 | YWHAH | S145 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
Q07912 | TNK2 | S856 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
Q12929 | EPS8 | S787 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
Q13009 | TIAM1 | S329 | psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
Q13207 | TBX2 | S355 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
Q13596 | SNX1 | S25 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
Q14318 | FKBP8 | S296 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}. |
Q14807 | KIF22 | S455 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
Q14807 | KIF22 | S562 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
Q52LW3 | ARHGAP29 | S578 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
Q53HC0 | CCDC92 | S209 | ochoa | Coiled-coil domain-containing protein 92 (Limkain beta-2) | Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface. {ECO:0000269|PubMed:32528005}. |
Q5JSH3 | WDR44 | S397 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
Q5JTV8 | TOR1AIP1 | S179 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
Q5T8P6 | RBM26 | S589 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
Q5TH69 | ARFGEF3 | S1049 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
Q5VUA4 | ZNF318 | S1888 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
Q68DK2 | ZFYVE26 | S703 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
Q6DN12 | MCTP2 | S145 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
Q6GQQ9 | OTUD7B | S776 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
Q6NV74 | CRACDL | S609 | ochoa | CRACD-like protein | None |
Q6NXS1 | PPP1R2B | S122 | ochoa|psp | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
Q6ZN28 | MACC1 | S34 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
Q6ZRS2 | SRCAP | S3172 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
Q76MJ5 | ERN2 | S902 | ochoa | Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}. |
Q7RTP6 | MICAL3 | S1192 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
Q7Z2W4 | ZC3HAV1 | S387 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
Q7Z5L9 | IRF2BP2 | S243 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
Q8N3D4 | EHBP1L1 | S993 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
Q8ND56 | LSM14A | S227 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
Q8ND76 | CCNY | S71 | ochoa|psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
Q8NFZ4 | NLGN2 | S718 | ochoa | Neuroligin-2 | Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}. |
Q8TBB5 | KLHDC4 | S413 | ochoa | Kelch domain-containing protein 4 | None |
Q8TC05 | MDM1 | S121 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
Q8TES7 | FBF1 | S359 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
Q92552 | MRPS27 | S301 | ochoa | Small ribosomal subunit protein mS27 (28S ribosomal protein S27, mitochondrial) (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27) | RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366). {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:28714366}. |
Q92585 | MAML1 | S303 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
Q92870 | APBB2 | S407 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
Q92966 | SNAPC3 | S74 | ochoa | snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}. |
Q96NE9 | FRMD6 | S537 | ochoa | FERM domain-containing protein 6 (Willin) | None |
Q96PE2 | ARHGEF17 | S790 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q96S59 | RANBP9 | S176 | ochoa | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
Q99569 | PKP4 | S77 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
Q99759 | MAP3K3 | S340 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
Q9BYB0 | SHANK3 | S891 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9BYB0 | SHANK3 | S1031 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9C0C2 | TNKS1BP1 | S592 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9H1K1 | ISCU | S29 | ochoa | Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) | [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}. |
Q9H9J4 | USP42 | S754 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
Q9HCC0 | MCCC2 | S499 | ochoa | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) | Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}. |
Q9HCK8 | CHD8 | S1976 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
Q9NWQ4 | GPATCH2L | S137 | ochoa | G patch domain-containing protein 2-like | None |
Q9NXR1 | NDE1 | S282 | ochoa|psp | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
Q9NYL2 | MAP3K20 | S362 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
Q9P2N5 | RBM27 | S657 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
Q9UGU5 | HMGXB4 | S387 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
Q9UGY1 | NOL12 | S134 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
Q9UHB6 | LIMA1 | S343 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
Q9UHR6 | ZNHIT2 | S165 | ochoa | Zinc finger HIT domain-containing protein 2 (Protein FON) | May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:28561026}. |
Q9UJ70 | NAGK | S76 | ochoa | N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}. |
Q9ULH0 | KIDINS220 | S1295 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
Q9UPQ0 | LIMCH1 | S226 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9Y343 | SNX24 | S116 | ochoa | Sorting nexin-24 | May be involved in several stages of intracellular trafficking. {ECO:0000250}. |
Q9Y3M8 | STARD13 | S457 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
Q9Y448 | KNSTRN | S232 | ochoa | Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}. |
Q9Y5J1 | UTP18 | S121 | ochoa | U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
U3KPZ7 | LOC127814297 | S602 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
V9GYY5 | None | S127 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}. |
P61604 | HSPE1 | S21 | Sugiyama | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}. |
P20674 | COX5A | S104 | Sugiyama | Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00427}. |
Q9Y6A5 | TACC3 | S552 | SIGNOR | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
P53621 | COPA | S389 | Sugiyama | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
P21802 | FGFR2 | S587 | Sugiyama | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
Q9Y4W2 | LAS1L | S636 | Sugiyama | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
Q14697 | GANAB | S169 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
Q9NPD3 | EXOSC4 | S77 | Sugiyama | Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}. |
P35613 | BSG | S228 | Sugiyama | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
Q96J92 | WNK4 | S130 | Sugiyama | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
Q9BYP7 | WNK3 | S44 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
P36578 | RPL4 | S139 | Sugiyama | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.072350e-06 | 5.970 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 8.798568e-07 | 6.056 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 4.850890e-06 | 5.314 |
R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 3.744186e-05 | 4.427 |
R-HSA-190241 | FGFR2 ligand binding and activation | 4.355763e-05 | 4.361 |
R-HSA-1226099 | Signaling by FGFR in disease | 3.364149e-05 | 4.473 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.752734e-05 | 4.426 |
R-HSA-5654695 | PI-3K cascade:FGFR2 | 8.560365e-05 | 4.068 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.087062e-04 | 3.964 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 1.218124e-04 | 3.914 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.477226e-04 | 3.606 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 2.712741e-04 | 3.567 |
R-HSA-5683057 | MAPK family signaling cascades | 3.674892e-04 | 3.435 |
R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 6.388753e-04 | 3.195 |
R-HSA-2033519 | Activated point mutants of FGFR2 | 6.711281e-04 | 3.173 |
R-HSA-109704 | PI3K Cascade | 9.025813e-04 | 3.045 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.613340e-03 | 2.792 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.613340e-03 | 2.792 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.613340e-03 | 2.792 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.613340e-03 | 2.792 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.613340e-03 | 2.792 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.322906e-03 | 2.878 |
R-HSA-73887 | Death Receptor Signaling | 1.692700e-03 | 2.771 |
R-HSA-112399 | IRS-mediated signalling | 1.369505e-03 | 2.863 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.700908e-03 | 2.769 |
R-HSA-5673001 | RAF/MAP kinase cascade | 1.969666e-03 | 2.706 |
R-HSA-2428924 | IGF1R signaling cascade | 1.983355e-03 | 2.703 |
R-HSA-74751 | Insulin receptor signalling cascade | 1.983355e-03 | 2.703 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.084291e-03 | 2.681 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.260123e-03 | 2.646 |
R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 2.495631e-03 | 2.603 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 2.495631e-03 | 2.603 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.903419e-03 | 2.537 |
R-HSA-162582 | Signal Transduction | 2.805285e-03 | 2.552 |
R-HSA-9930044 | Nuclear RNA decay | 3.008003e-03 | 2.522 |
R-HSA-1980143 | Signaling by NOTCH1 | 3.438567e-03 | 2.464 |
R-HSA-5654738 | Signaling by FGFR2 | 4.051391e-03 | 2.392 |
R-HSA-190377 | FGFR2b ligand binding and activation | 4.799772e-03 | 2.319 |
R-HSA-4641265 | Repression of WNT target genes | 6.210170e-03 | 2.207 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.630204e-03 | 2.178 |
R-HSA-190375 | FGFR2c ligand binding and activation | 6.977704e-03 | 2.156 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.236737e-03 | 2.140 |
R-HSA-74752 | Signaling by Insulin receptor | 6.769954e-03 | 2.169 |
R-HSA-190236 | Signaling by FGFR | 8.495438e-03 | 2.071 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 8.547381e-03 | 2.068 |
R-HSA-9012852 | Signaling by NOTCH3 | 1.118561e-02 | 1.951 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.264508e-02 | 1.898 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.652158e-02 | 1.782 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.800475e-02 | 1.745 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.797509e-02 | 1.745 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.818897e-02 | 1.740 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.679262e-02 | 1.775 |
R-HSA-8853333 | Signaling by FGFR2 fusions | 2.156333e-02 | 1.666 |
R-HSA-5602636 | IKBKB deficiency causes SCID | 2.156333e-02 | 1.666 |
R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.156333e-02 | 1.666 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.165463e-02 | 1.664 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.185058e-02 | 1.661 |
R-HSA-9013694 | Signaling by NOTCH4 | 2.235076e-02 | 1.651 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.439050e-02 | 1.613 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.439050e-02 | 1.613 |
R-HSA-6802957 | Oncogenic MAPK signaling | 3.080769e-02 | 1.511 |
R-HSA-209563 | Axonal growth stimulation | 3.568211e-02 | 1.448 |
R-HSA-9909438 | 3-Methylcrotonyl-CoA carboxylase deficiency | 3.568211e-02 | 1.448 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.603436e-02 | 1.443 |
R-HSA-1980145 | Signaling by NOTCH2 | 3.627125e-02 | 1.440 |
R-HSA-165181 | Inhibition of TSC complex formation by PKB | 4.266556e-02 | 1.370 |
R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 4.266556e-02 | 1.370 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.119510e-02 | 1.385 |
R-HSA-157118 | Signaling by NOTCH | 4.182396e-02 | 1.379 |
R-HSA-72312 | rRNA processing | 3.740670e-02 | 1.427 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.119510e-02 | 1.385 |
R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 6.331649e-02 | 1.198 |
R-HSA-9732724 | IFNG signaling activates MAPKs | 7.010150e-02 | 1.154 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 7.010150e-02 | 1.154 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 7.683778e-02 | 1.114 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 7.683778e-02 | 1.114 |
R-HSA-170984 | ARMS-mediated activation | 8.352567e-02 | 1.078 |
R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.033025e-01 | 0.986 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.098003e-01 | 0.959 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.353278e-01 | 0.869 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.478181e-01 | 0.830 |
R-HSA-9656223 | Signaling by RAF1 mutants | 4.991893e-02 | 1.302 |
R-HSA-210991 | Basigin interactions | 1.722645e-01 | 0.764 |
R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.722645e-01 | 0.764 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 5.924117e-02 | 1.227 |
R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.782666e-01 | 0.749 |
R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.842256e-01 | 0.735 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 9.472267e-02 | 1.024 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 9.472267e-02 | 1.024 |
R-HSA-8854518 | AURKA Activation by TPX2 | 1.014975e-01 | 0.994 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.177965e-01 | 0.929 |
R-HSA-380287 | Centrosome maturation | 1.225684e-01 | 0.912 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.571541e-01 | 0.804 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.303805e-01 | 0.638 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.722645e-01 | 0.764 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.924117e-02 | 1.227 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.924117e-02 | 1.227 |
R-HSA-5674135 | MAP2K and MAPK activation | 4.991893e-02 | 1.302 |
R-HSA-6802949 | Signaling by RAS mutants | 5.924117e-02 | 1.227 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.098003e-01 | 0.959 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.662188e-01 | 0.779 |
R-HSA-5673000 | RAF activation | 2.579025e-01 | 0.589 |
R-HSA-354192 | Integrin signaling | 2.470128e-01 | 0.607 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.812455e-02 | 1.318 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.353278e-01 | 0.869 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.828525e-01 | 0.738 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 5.648240e-02 | 1.248 |
R-HSA-9017802 | Noncanonical activation of NOTCH3 | 5.648240e-02 | 1.248 |
R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 7.010150e-02 | 1.154 |
R-HSA-193697 | p75NTR regulates axonogenesis | 8.352567e-02 | 1.078 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.033025e-01 | 0.986 |
R-HSA-209560 | NF-kB is activated and signals survival | 1.033025e-01 | 0.986 |
R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.098003e-01 | 0.959 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.162514e-01 | 0.935 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.226561e-01 | 0.911 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.290148e-01 | 0.889 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.539960e-01 | 0.812 |
R-HSA-350054 | Notch-HLH transcription pathway | 1.842256e-01 | 0.735 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.960153e-01 | 0.708 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 4.991893e-02 | 1.302 |
R-HSA-5260271 | Diseases of Immune System | 4.635452e-02 | 1.334 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.635452e-02 | 1.334 |
R-HSA-6794361 | Neurexins and neuroligins | 7.114331e-02 | 1.148 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.076361e-01 | 0.683 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.290148e-01 | 0.889 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.518077e-01 | 0.599 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.518077e-01 | 0.599 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.598570e-01 | 0.585 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.598570e-01 | 0.585 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 5.648240e-02 | 1.248 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 7.683778e-02 | 1.114 |
R-HSA-9839383 | TGFBR3 PTM regulation | 7.683778e-02 | 1.114 |
R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 9.016553e-02 | 1.045 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.290148e-01 | 0.889 |
R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 1.601295e-01 | 0.796 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.601295e-01 | 0.796 |
R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 1.662188e-01 | 0.779 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.722645e-01 | 0.764 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.117271e-02 | 1.213 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.445871e-01 | 0.840 |
R-HSA-169893 | Prolonged ERK activation events | 1.353278e-01 | 0.869 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.303805e-01 | 0.638 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 6.331649e-02 | 1.198 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.303805e-01 | 0.638 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.960153e-01 | 0.708 |
R-HSA-9020702 | Interleukin-1 signaling | 1.959262e-01 | 0.708 |
R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 7.010150e-02 | 1.154 |
R-HSA-9683686 | Maturation of spike protein | 9.016553e-02 | 1.045 |
R-HSA-937039 | IRAK1 recruits IKK complex | 1.098003e-01 | 0.959 |
R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.098003e-01 | 0.959 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.226561e-01 | 0.911 |
R-HSA-69166 | Removal of the Flap Intermediate | 1.226561e-01 | 0.911 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.290148e-01 | 0.889 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.353278e-01 | 0.869 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.478181e-01 | 0.830 |
R-HSA-429947 | Deadenylation of mRNA | 1.960153e-01 | 0.708 |
R-HSA-6794362 | Protein-protein interactions at synapses | 1.470832e-01 | 0.832 |
R-HSA-196780 | Biotin transport and metabolism | 1.290148e-01 | 0.889 |
R-HSA-193639 | p75NTR signals via NF-kB | 1.290148e-01 | 0.889 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 8.374497e-02 | 1.077 |
R-HSA-430116 | GP1b-IX-V activation signalling | 8.352567e-02 | 1.078 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.715814e-02 | 1.173 |
R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 8.352567e-02 | 1.078 |
R-HSA-193692 | Regulated proteolysis of p75NTR | 8.352567e-02 | 1.078 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 9.675769e-02 | 1.014 |
R-HSA-8851805 | MET activates RAS signaling | 1.098003e-01 | 0.959 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.162514e-01 | 0.935 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.290148e-01 | 0.889 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.353278e-01 | 0.869 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 8.590754e-02 | 1.066 |
R-HSA-187687 | Signalling to ERKs | 2.632887e-01 | 0.580 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.539960e-01 | 0.812 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.107315e-01 | 0.956 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 5.648240e-02 | 1.248 |
R-HSA-3323169 | Defects in biotin (Btn) metabolism | 8.352567e-02 | 1.078 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.290148e-01 | 0.889 |
R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.478181e-01 | 0.830 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.539960e-01 | 0.812 |
R-HSA-5617833 | Cilium Assembly | 1.950191e-01 | 0.710 |
R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 1.722645e-01 | 0.764 |
R-HSA-8953854 | Metabolism of RNA | 9.404189e-02 | 1.027 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.467239e-02 | 1.350 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 9.249486e-02 | 1.034 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 1.226561e-01 | 0.911 |
R-HSA-69183 | Processive synthesis on the lagging strand | 1.290148e-01 | 0.889 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.290148e-01 | 0.889 |
R-HSA-392517 | Rap1 signalling | 1.601295e-01 | 0.796 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.782666e-01 | 0.749 |
R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 1.901417e-01 | 0.721 |
R-HSA-193648 | NRAGE signals death through JNK | 7.947176e-02 | 1.100 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.076361e-01 | 0.683 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.133839e-01 | 0.671 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.190904e-01 | 0.659 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.524773e-01 | 0.598 |
R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 1.662188e-01 | 0.779 |
R-HSA-112311 | Neurotransmitter clearance | 2.303805e-01 | 0.638 |
R-HSA-5689880 | Ub-specific processing proteases | 5.208443e-02 | 1.283 |
R-HSA-75893 | TNF signaling | 7.947176e-02 | 1.100 |
R-HSA-3214842 | HDMs demethylate histones | 2.018467e-01 | 0.695 |
R-HSA-209543 | p75NTR recruits signalling complexes | 1.098003e-01 | 0.959 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.098003e-01 | 0.959 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.866951e-02 | 1.104 |
R-HSA-2682334 | EPH-Ephrin signaling | 1.699191e-01 | 0.770 |
R-HSA-114452 | Activation of BH3-only proteins | 2.303805e-01 | 0.638 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.683778e-02 | 1.114 |
R-HSA-9842663 | Signaling by LTK | 1.098003e-01 | 0.959 |
R-HSA-9865881 | Complex III assembly | 1.960153e-01 | 0.708 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 5.924117e-02 | 1.227 |
R-HSA-69186 | Lagging Strand Synthesis | 1.722645e-01 | 0.764 |
R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 2.076361e-01 | 0.683 |
R-HSA-381042 | PERK regulates gene expression | 2.632887e-01 | 0.580 |
R-HSA-1236974 | ER-Phagosome pathway | 1.596922e-01 | 0.797 |
R-HSA-5688426 | Deubiquitination | 5.092704e-02 | 1.293 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.632887e-01 | 0.580 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.662188e-01 | 0.779 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.133839e-01 | 0.671 |
R-HSA-5686938 | Regulation of TLR by endogenous ligand | 2.579025e-01 | 0.589 |
R-HSA-901042 | Calnexin/calreticulin cycle | 2.579025e-01 | 0.589 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.470832e-01 | 0.832 |
R-HSA-4086398 | Ca2+ pathway | 1.177965e-01 | 0.929 |
R-HSA-216083 | Integrin cell surface interactions | 1.298131e-01 | 0.887 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.842256e-01 | 0.735 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.470128e-01 | 0.607 |
R-HSA-69190 | DNA strand elongation | 2.415087e-01 | 0.617 |
R-HSA-416482 | G alpha (12/13) signalling events | 1.298131e-01 | 0.887 |
R-HSA-195721 | Signaling by WNT | 2.013738e-01 | 0.696 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 1.822433e-01 | 0.739 |
R-HSA-9694301 | Maturation of replicase proteins | 7.010150e-02 | 1.154 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.901417e-01 | 0.721 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 2.579025e-01 | 0.589 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 2.632887e-01 | 0.580 |
R-HSA-182971 | EGFR downregulation | 2.359646e-01 | 0.627 |
R-HSA-1236975 | Antigen processing-Cross presentation | 2.170716e-01 | 0.663 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 7.947176e-02 | 1.100 |
R-HSA-1538133 | G0 and Early G1 | 2.415087e-01 | 0.617 |
R-HSA-75153 | Apoptotic execution phase | 5.924117e-02 | 1.227 |
R-HSA-2672351 | Stimuli-sensing channels | 5.763573e-02 | 1.239 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.842256e-01 | 0.735 |
R-HSA-109581 | Apoptosis | 1.437892e-01 | 0.842 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.415087e-01 | 0.617 |
R-HSA-162594 | Early Phase of HIV Life Cycle | 1.722645e-01 | 0.764 |
R-HSA-1257604 | PIP3 activates AKT signaling | 8.046997e-02 | 1.094 |
R-HSA-5357801 | Programmed Cell Death | 2.249925e-01 | 0.648 |
R-HSA-9006936 | Signaling by TGFB family members | 1.404404e-01 | 0.853 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.854568e-01 | 0.732 |
R-HSA-983712 | Ion channel transport | 1.931801e-01 | 0.714 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.403098e-01 | 0.619 |
R-HSA-9006925 | Intracellular signaling by second messengers | 1.246280e-01 | 0.904 |
R-HSA-6809371 | Formation of the cornified envelope | 2.652254e-01 | 0.576 |
R-HSA-74158 | RNA Polymerase III Transcription | 2.686361e-01 | 0.571 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.686361e-01 | 0.571 |
R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 2.686361e-01 | 0.571 |
R-HSA-8853659 | RET signaling | 2.686361e-01 | 0.571 |
R-HSA-5689896 | Ovarian tumor domain proteases | 2.739450e-01 | 0.562 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.739450e-01 | 0.562 |
R-HSA-9694516 | SARS-CoV-2 Infection | 2.809061e-01 | 0.551 |
R-HSA-201556 | Signaling by ALK | 2.844485e-01 | 0.546 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.896436e-01 | 0.538 |
R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 2.896436e-01 | 0.538 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.896436e-01 | 0.538 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.920528e-01 | 0.535 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.948013e-01 | 0.530 |
R-HSA-9694548 | Maturation of spike protein | 2.948013e-01 | 0.530 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.948013e-01 | 0.530 |
R-HSA-442660 | SLC-mediated transport of neurotransmitters | 2.999219e-01 | 0.523 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.999219e-01 | 0.523 |
R-HSA-9683701 | Translation of Structural Proteins | 2.999219e-01 | 0.523 |
R-HSA-165159 | MTOR signalling | 3.050056e-01 | 0.516 |
R-HSA-9018519 | Estrogen-dependent gene expression | 3.054293e-01 | 0.515 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.054293e-01 | 0.515 |
R-HSA-8854214 | TBC/RABGAPs | 3.100527e-01 | 0.509 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 3.134345e-01 | 0.504 |
R-HSA-3928662 | EPHB-mediated forward signaling | 3.150635e-01 | 0.502 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.150635e-01 | 0.502 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.200382e-01 | 0.495 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.249770e-01 | 0.488 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 3.249770e-01 | 0.488 |
R-HSA-9839373 | Signaling by TGFBR3 | 3.249770e-01 | 0.488 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.298803e-01 | 0.482 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 3.373236e-01 | 0.472 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.395812e-01 | 0.469 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.399640e-01 | 0.469 |
R-HSA-166520 | Signaling by NTRKs | 3.399640e-01 | 0.469 |
R-HSA-69242 | S Phase | 3.399640e-01 | 0.469 |
R-HSA-9856651 | MITF-M-dependent gene expression | 3.452353e-01 | 0.462 |
R-HSA-9864848 | Complex IV assembly | 3.491429e-01 | 0.457 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.491429e-01 | 0.457 |
R-HSA-70895 | Branched-chain amino acid catabolism | 3.491429e-01 | 0.457 |
R-HSA-446652 | Interleukin-1 family signaling | 3.504932e-01 | 0.455 |
R-HSA-1266738 | Developmental Biology | 3.555952e-01 | 0.449 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.585672e-01 | 0.445 |
R-HSA-199991 | Membrane Trafficking | 3.590754e-01 | 0.445 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.724507e-01 | 0.429 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.724507e-01 | 0.429 |
R-HSA-177929 | Signaling by EGFR | 3.724507e-01 | 0.429 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 3.770120e-01 | 0.424 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.770120e-01 | 0.424 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.815404e-01 | 0.418 |
R-HSA-186712 | Regulation of beta-cell development | 3.860362e-01 | 0.413 |
R-HSA-180786 | Extension of Telomeres | 3.860362e-01 | 0.413 |
R-HSA-983189 | Kinesins | 3.904995e-01 | 0.408 |
R-HSA-422475 | Axon guidance | 3.934867e-01 | 0.405 |
R-HSA-9793380 | Formation of paraxial mesoderm | 3.949307e-01 | 0.403 |
R-HSA-450294 | MAP kinase activation | 3.949307e-01 | 0.403 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.021953e-01 | 0.396 |
R-HSA-446203 | Asparagine N-linked glycosylation | 4.023139e-01 | 0.395 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.036975e-01 | 0.394 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.072647e-01 | 0.390 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.072647e-01 | 0.390 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.080336e-01 | 0.389 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.123137e-01 | 0.385 |
R-HSA-9678108 | SARS-CoV-1 Infection | 4.123137e-01 | 0.385 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.166121e-01 | 0.380 |
R-HSA-1643685 | Disease | 4.168514e-01 | 0.380 |
R-HSA-611105 | Respiratory electron transport | 4.198479e-01 | 0.377 |
R-HSA-69278 | Cell Cycle, Mitotic | 4.237263e-01 | 0.373 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.250674e-01 | 0.372 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.334011e-01 | 0.363 |
R-HSA-204005 | COPII-mediated vesicle transport | 4.334011e-01 | 0.363 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.334011e-01 | 0.363 |
R-HSA-448424 | Interleukin-17 signaling | 4.334011e-01 | 0.363 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.334011e-01 | 0.363 |
R-HSA-1640170 | Cell Cycle | 4.371350e-01 | 0.359 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.375230e-01 | 0.359 |
R-HSA-69275 | G2/M Transition | 4.396980e-01 | 0.357 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.416151e-01 | 0.355 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.416151e-01 | 0.355 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.416151e-01 | 0.355 |
R-HSA-453274 | Mitotic G2-G2/M phases | 4.446036e-01 | 0.352 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.456777e-01 | 0.351 |
R-HSA-9749641 | Aspirin ADME | 4.456777e-01 | 0.351 |
R-HSA-9675108 | Nervous system development | 4.466034e-01 | 0.350 |
R-HSA-69473 | G2/M DNA damage checkpoint | 4.497110e-01 | 0.347 |
R-HSA-1236394 | Signaling by ERBB4 | 4.497110e-01 | 0.347 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 4.498510e-01 | 0.347 |
R-HSA-168898 | Toll-like Receptor Cascades | 4.519177e-01 | 0.345 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.537152e-01 | 0.343 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.543438e-01 | 0.343 |
R-HSA-68877 | Mitotic Prometaphase | 4.567638e-01 | 0.340 |
R-HSA-9694635 | Translation of Structural Proteins | 4.616372e-01 | 0.336 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.639872e-01 | 0.333 |
R-HSA-9955298 | SLC-mediated transport of organic anions | 4.655553e-01 | 0.332 |
R-HSA-9659379 | Sensory processing of sound | 4.694452e-01 | 0.328 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.718180e-01 | 0.326 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.733070e-01 | 0.325 |
R-HSA-6806834 | Signaling by MET | 4.733070e-01 | 0.325 |
R-HSA-9833482 | PKR-mediated signaling | 4.733070e-01 | 0.325 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.735314e-01 | 0.325 |
R-HSA-977225 | Amyloid fiber formation | 4.771409e-01 | 0.321 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.782656e-01 | 0.320 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 4.847260e-01 | 0.315 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.890738e-01 | 0.311 |
R-HSA-6805567 | Keratinization | 4.899882e-01 | 0.310 |
R-HSA-141424 | Amplification of signal from the kinetochores | 4.958995e-01 | 0.305 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.958995e-01 | 0.305 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.995703e-01 | 0.301 |
R-HSA-70268 | Pyruvate metabolism | 5.032146e-01 | 0.298 |
R-HSA-156902 | Peptide chain elongation | 5.068327e-01 | 0.295 |
R-HSA-68882 | Mitotic Anaphase | 5.129382e-01 | 0.290 |
R-HSA-202424 | Downstream TCR signaling | 5.139905e-01 | 0.289 |
R-HSA-73884 | Base Excision Repair | 5.139905e-01 | 0.289 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.151961e-01 | 0.288 |
R-HSA-418990 | Adherens junctions interactions | 5.174472e-01 | 0.286 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.175307e-01 | 0.286 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.175307e-01 | 0.286 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.175307e-01 | 0.286 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.210454e-01 | 0.283 |
R-HSA-381070 | IRE1alpha activates chaperones | 5.210454e-01 | 0.283 |
R-HSA-156842 | Eukaryotic Translation Elongation | 5.245346e-01 | 0.280 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.245346e-01 | 0.280 |
R-HSA-9837999 | Mitochondrial protein degradation | 5.314377e-01 | 0.275 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.348519e-01 | 0.272 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.348519e-01 | 0.272 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.382414e-01 | 0.269 |
R-HSA-72764 | Eukaryotic Translation Termination | 5.382414e-01 | 0.269 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 5.382414e-01 | 0.269 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 5.395785e-01 | 0.268 |
R-HSA-5389840 | Mitochondrial translation elongation | 5.416065e-01 | 0.266 |
R-HSA-6807878 | COPI-mediated anterograde transport | 5.416065e-01 | 0.266 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.416065e-01 | 0.266 |
R-HSA-157579 | Telomere Maintenance | 5.449472e-01 | 0.264 |
R-HSA-8957275 | Post-translational protein phosphorylation | 5.482637e-01 | 0.261 |
R-HSA-5368286 | Mitochondrial translation initiation | 5.482637e-01 | 0.261 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.482637e-01 | 0.261 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.482637e-01 | 0.261 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.482637e-01 | 0.261 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 5.548252e-01 | 0.256 |
R-HSA-5610787 | Hedgehog 'off' state | 5.548252e-01 | 0.256 |
R-HSA-2408557 | Selenocysteine synthesis | 5.580703e-01 | 0.253 |
R-HSA-8939211 | ESR-mediated signaling | 5.588976e-01 | 0.253 |
R-HSA-5653656 | Vesicle-mediated transport | 5.623936e-01 | 0.250 |
R-HSA-68886 | M Phase | 5.632064e-01 | 0.249 |
R-HSA-192823 | Viral mRNA Translation | 5.644905e-01 | 0.248 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 5.644905e-01 | 0.248 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.676658e-01 | 0.246 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 5.676658e-01 | 0.246 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.739478e-01 | 0.241 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 5.770547e-01 | 0.239 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.801392e-01 | 0.236 |
R-HSA-69239 | Synthesis of DNA | 5.801392e-01 | 0.236 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.832014e-01 | 0.234 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.832014e-01 | 0.234 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.832014e-01 | 0.234 |
R-HSA-5419276 | Mitochondrial translation termination | 5.862414e-01 | 0.232 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.862414e-01 | 0.232 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.862414e-01 | 0.232 |
R-HSA-421270 | Cell-cell junction organization | 5.878020e-01 | 0.231 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.892595e-01 | 0.230 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 5.892595e-01 | 0.230 |
R-HSA-202403 | TCR signaling | 5.892595e-01 | 0.230 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.952303e-01 | 0.225 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.952303e-01 | 0.225 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.981833e-01 | 0.223 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 5.981833e-01 | 0.223 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.011150e-01 | 0.221 |
R-HSA-69620 | Cell Cycle Checkpoints | 6.017259e-01 | 0.221 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.040254e-01 | 0.219 |
R-HSA-9679506 | SARS-CoV Infections | 6.058437e-01 | 0.218 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.069148e-01 | 0.217 |
R-HSA-72613 | Eukaryotic Translation Initiation | 6.126311e-01 | 0.213 |
R-HSA-72737 | Cap-dependent Translation Initiation | 6.126311e-01 | 0.213 |
R-HSA-373760 | L1CAM interactions | 6.126311e-01 | 0.213 |
R-HSA-9007101 | Rab regulation of trafficking | 6.154582e-01 | 0.211 |
R-HSA-8953897 | Cellular responses to stimuli | 6.179860e-01 | 0.209 |
R-HSA-5693538 | Homology Directed Repair | 6.182649e-01 | 0.209 |
R-HSA-9711123 | Cellular response to chemical stress | 6.210048e-01 | 0.207 |
R-HSA-68875 | Mitotic Prophase | 6.238175e-01 | 0.205 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.265637e-01 | 0.203 |
R-HSA-73886 | Chromosome Maintenance | 6.265637e-01 | 0.203 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.265637e-01 | 0.203 |
R-HSA-2132295 | MHC class II antigen presentation | 6.319966e-01 | 0.199 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 6.322270e-01 | 0.199 |
R-HSA-2262752 | Cellular responses to stress | 6.355486e-01 | 0.197 |
R-HSA-446728 | Cell junction organization | 6.395652e-01 | 0.194 |
R-HSA-69206 | G1/S Transition | 6.399993e-01 | 0.194 |
R-HSA-114608 | Platelet degranulation | 6.452384e-01 | 0.190 |
R-HSA-69481 | G2/M Checkpoints | 6.452384e-01 | 0.190 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.478295e-01 | 0.189 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 6.580076e-01 | 0.182 |
R-HSA-1474228 | Degradation of the extracellular matrix | 6.605062e-01 | 0.180 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.629867e-01 | 0.178 |
R-HSA-9948299 | Ribosome-associated quality control | 6.774970e-01 | 0.169 |
R-HSA-5368287 | Mitochondrial translation | 6.774970e-01 | 0.169 |
R-HSA-5358351 | Signaling by Hedgehog | 6.774970e-01 | 0.169 |
R-HSA-1632852 | Macroautophagy | 6.845181e-01 | 0.165 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.891144e-01 | 0.162 |
R-HSA-112316 | Neuronal System | 6.931598e-01 | 0.159 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 6.936443e-01 | 0.159 |
R-HSA-449147 | Signaling by Interleukins | 6.947875e-01 | 0.158 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.981088e-01 | 0.156 |
R-HSA-109582 | Hemostasis | 7.008809e-01 | 0.154 |
R-HSA-1500931 | Cell-Cell communication | 7.036649e-01 | 0.153 |
R-HSA-9758941 | Gastrulation | 7.046848e-01 | 0.152 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.089897e-01 | 0.149 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.111188e-01 | 0.148 |
R-HSA-9609507 | Protein localization | 7.132324e-01 | 0.147 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 7.132324e-01 | 0.147 |
R-HSA-69306 | DNA Replication | 7.132324e-01 | 0.147 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.153307e-01 | 0.145 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.174138e-01 | 0.144 |
R-HSA-9612973 | Autophagy | 7.194817e-01 | 0.143 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 7.215347e-01 | 0.142 |
R-HSA-162587 | HIV Life Cycle | 7.215347e-01 | 0.142 |
R-HSA-9711097 | Cellular response to starvation | 7.235727e-01 | 0.141 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.235727e-01 | 0.141 |
R-HSA-877300 | Interferon gamma signaling | 7.255960e-01 | 0.139 |
R-HSA-1474244 | Extracellular matrix organization | 7.262587e-01 | 0.139 |
R-HSA-2467813 | Separation of Sister Chromatids | 7.354941e-01 | 0.133 |
R-HSA-2408522 | Selenoamino acid metabolism | 7.354941e-01 | 0.133 |
R-HSA-5619102 | SLC transporter disorders | 7.412623e-01 | 0.130 |
R-HSA-418555 | G alpha (s) signalling events | 7.505999e-01 | 0.125 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.524270e-01 | 0.124 |
R-HSA-168255 | Influenza Infection | 7.648500e-01 | 0.116 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 7.696555e-01 | 0.114 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 7.894277e-01 | 0.103 |
R-HSA-597592 | Post-translational protein modification | 7.897712e-01 | 0.102 |
R-HSA-913531 | Interferon Signaling | 7.948039e-01 | 0.100 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.948039e-01 | 0.100 |
R-HSA-389948 | Co-inhibition by PD-1 | 7.985297e-01 | 0.098 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.029333e-01 | 0.095 |
R-HSA-376176 | Signaling by ROBO receptors | 8.029333e-01 | 0.095 |
R-HSA-72172 | mRNA Splicing | 8.058159e-01 | 0.094 |
R-HSA-425407 | SLC-mediated transmembrane transport | 8.102062e-01 | 0.091 |
R-HSA-9748784 | Drug ADME | 8.248564e-01 | 0.084 |
R-HSA-162906 | HIV Infection | 8.361069e-01 | 0.078 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.396954e-01 | 0.076 |
R-HSA-72766 | Translation | 8.416329e-01 | 0.075 |
R-HSA-3247509 | Chromatin modifying enzymes | 8.443592e-01 | 0.073 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 8.477685e-01 | 0.072 |
R-HSA-9824446 | Viral Infection Pathways | 8.478517e-01 | 0.072 |
R-HSA-5619115 | Disorders of transmembrane transporters | 8.586070e-01 | 0.066 |
R-HSA-382551 | Transport of small molecules | 8.594700e-01 | 0.066 |
R-HSA-4839726 | Chromatin organization | 8.606811e-01 | 0.065 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.677055e-01 | 0.062 |
R-HSA-73857 | RNA Polymerase II Transcription | 8.866045e-01 | 0.052 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.884045e-01 | 0.051 |
R-HSA-1280218 | Adaptive Immune System | 8.934594e-01 | 0.049 |
R-HSA-212436 | Generic Transcription Pathway | 8.946169e-01 | 0.048 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 9.057942e-01 | 0.043 |
R-HSA-392499 | Metabolism of proteins | 9.131491e-01 | 0.039 |
R-HSA-112315 | Transmission across Chemical Synapses | 9.194655e-01 | 0.036 |
R-HSA-388396 | GPCR downstream signalling | 9.321055e-01 | 0.031 |
R-HSA-73894 | DNA Repair | 9.388286e-01 | 0.027 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.406227e-01 | 0.027 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.488818e-01 | 0.023 |
R-HSA-372790 | Signaling by GPCR | 9.570695e-01 | 0.019 |
R-HSA-74160 | Gene expression (Transcription) | 9.604826e-01 | 0.018 |
R-HSA-5668914 | Diseases of metabolism | 9.631604e-01 | 0.016 |
R-HSA-6798695 | Neutrophil degranulation | 9.705661e-01 | 0.013 |
R-HSA-5663205 | Infectious disease | 9.882896e-01 | 0.005 |
R-HSA-168249 | Innate Immune System | 9.904765e-01 | 0.004 |
R-HSA-168256 | Immune System | 9.997403e-01 | 0.000 |
R-HSA-9709957 | Sensory Perception | 9.999264e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.835 | 0.230 | 1 | 0.831 |
COT |
0.833 | 0.156 | 2 | 0.786 |
CDC7 |
0.823 | 0.125 | 1 | 0.852 |
GRK1 |
0.821 | 0.162 | -2 | 0.783 |
NDR2 |
0.820 | 0.108 | -3 | 0.815 |
RSK2 |
0.820 | 0.160 | -3 | 0.779 |
PIM3 |
0.819 | 0.104 | -3 | 0.831 |
MOS |
0.818 | 0.131 | 1 | 0.846 |
IKKB |
0.818 | 0.016 | -2 | 0.751 |
BMPR1B |
0.818 | 0.314 | 1 | 0.839 |
SRPK1 |
0.817 | 0.156 | -3 | 0.771 |
FAM20C |
0.815 | 0.196 | 2 | 0.683 |
DSTYK |
0.815 | 0.061 | 2 | 0.825 |
CAMK2G |
0.815 | 0.060 | 2 | 0.803 |
PRKD1 |
0.814 | 0.128 | -3 | 0.801 |
CAMK1B |
0.814 | 0.105 | -3 | 0.852 |
MTOR |
0.812 | -0.026 | 1 | 0.775 |
PRPK |
0.812 | -0.035 | -1 | 0.833 |
RAF1 |
0.812 | -0.018 | 1 | 0.829 |
CAMK2B |
0.812 | 0.167 | 2 | 0.805 |
PIM1 |
0.811 | 0.140 | -3 | 0.790 |
GCN2 |
0.810 | -0.074 | 2 | 0.760 |
CDKL1 |
0.810 | 0.101 | -3 | 0.809 |
P90RSK |
0.810 | 0.105 | -3 | 0.780 |
GRK6 |
0.810 | 0.119 | 1 | 0.840 |
MST4 |
0.810 | 0.093 | 2 | 0.787 |
NDR1 |
0.810 | 0.075 | -3 | 0.816 |
PRKD2 |
0.810 | 0.130 | -3 | 0.766 |
GRK5 |
0.809 | 0.025 | -3 | 0.831 |
SRPK2 |
0.809 | 0.139 | -3 | 0.702 |
KIS |
0.809 | 0.068 | 1 | 0.695 |
RSK3 |
0.809 | 0.107 | -3 | 0.776 |
CAMK2D |
0.809 | 0.093 | -3 | 0.817 |
CDKL5 |
0.809 | 0.125 | -3 | 0.796 |
TGFBR1 |
0.809 | 0.264 | -2 | 0.878 |
MARK4 |
0.808 | 0.081 | 4 | 0.809 |
ERK5 |
0.808 | 0.067 | 1 | 0.833 |
CAMK2A |
0.808 | 0.144 | 2 | 0.806 |
TGFBR2 |
0.808 | 0.111 | -2 | 0.845 |
CLK2 |
0.808 | 0.181 | -3 | 0.770 |
MAPKAPK2 |
0.807 | 0.130 | -3 | 0.734 |
TBK1 |
0.807 | -0.055 | 1 | 0.729 |
IKKA |
0.807 | 0.032 | -2 | 0.745 |
GRK7 |
0.807 | 0.166 | 1 | 0.776 |
SKMLCK |
0.807 | 0.065 | -2 | 0.795 |
ULK2 |
0.807 | -0.080 | 2 | 0.712 |
BMPR2 |
0.807 | 0.019 | -2 | 0.881 |
RSK4 |
0.806 | 0.138 | -3 | 0.751 |
LATS2 |
0.806 | 0.073 | -5 | 0.674 |
PKN3 |
0.806 | 0.054 | -3 | 0.817 |
HIPK4 |
0.806 | 0.087 | 1 | 0.746 |
NEK6 |
0.806 | 0.012 | -2 | 0.843 |
NLK |
0.806 | 0.004 | 1 | 0.808 |
AURC |
0.805 | 0.100 | -2 | 0.620 |
AMPKA1 |
0.805 | 0.104 | -3 | 0.831 |
PDHK4 |
0.805 | -0.169 | 1 | 0.817 |
NUAK2 |
0.805 | 0.055 | -3 | 0.839 |
ATR |
0.805 | -0.016 | 1 | 0.784 |
WNK1 |
0.804 | 0.036 | -2 | 0.822 |
IKKE |
0.804 | -0.070 | 1 | 0.731 |
PKACG |
0.804 | 0.091 | -2 | 0.724 |
SRPK3 |
0.804 | 0.121 | -3 | 0.749 |
P70S6KB |
0.803 | 0.097 | -3 | 0.794 |
ICK |
0.803 | 0.093 | -3 | 0.834 |
CHAK2 |
0.803 | 0.050 | -1 | 0.857 |
HUNK |
0.803 | -0.025 | 2 | 0.767 |
ALK4 |
0.803 | 0.216 | -2 | 0.896 |
PRKX |
0.802 | 0.163 | -3 | 0.695 |
TSSK2 |
0.802 | 0.108 | -5 | 0.784 |
NIK |
0.802 | 0.014 | -3 | 0.855 |
ALK2 |
0.802 | 0.270 | -2 | 0.872 |
TSSK1 |
0.801 | 0.126 | -3 | 0.843 |
GRK4 |
0.801 | -0.019 | -2 | 0.819 |
BMPR1A |
0.801 | 0.278 | 1 | 0.825 |
NEK7 |
0.801 | -0.080 | -3 | 0.815 |
PKACB |
0.800 | 0.116 | -2 | 0.636 |
CAMLCK |
0.800 | 0.021 | -2 | 0.803 |
AMPKA2 |
0.800 | 0.094 | -3 | 0.804 |
PKN2 |
0.799 | 0.037 | -3 | 0.823 |
PKCD |
0.799 | 0.046 | 2 | 0.698 |
MAPKAPK3 |
0.799 | 0.061 | -3 | 0.765 |
BCKDK |
0.799 | -0.072 | -1 | 0.807 |
PDHK1 |
0.798 | -0.165 | 1 | 0.812 |
DAPK2 |
0.798 | 0.018 | -3 | 0.850 |
ACVR2B |
0.797 | 0.189 | -2 | 0.855 |
ACVR2A |
0.797 | 0.176 | -2 | 0.852 |
MLK1 |
0.797 | -0.102 | 2 | 0.731 |
LATS1 |
0.796 | 0.119 | -3 | 0.822 |
ULK1 |
0.796 | -0.127 | -3 | 0.779 |
CLK4 |
0.796 | 0.093 | -3 | 0.781 |
ATM |
0.795 | 0.013 | 1 | 0.735 |
QSK |
0.795 | 0.067 | 4 | 0.788 |
NIM1 |
0.795 | 0.003 | 3 | 0.603 |
CK2A2 |
0.794 | 0.208 | 1 | 0.708 |
BRSK1 |
0.794 | 0.050 | -3 | 0.788 |
MSK2 |
0.794 | 0.028 | -3 | 0.753 |
PAK1 |
0.793 | 0.015 | -2 | 0.717 |
MARK3 |
0.793 | 0.077 | 4 | 0.756 |
PLK1 |
0.793 | 0.033 | -2 | 0.793 |
PRKD3 |
0.793 | 0.087 | -3 | 0.758 |
MSK1 |
0.793 | 0.063 | -3 | 0.753 |
MNK2 |
0.792 | 0.042 | -2 | 0.732 |
CLK1 |
0.792 | 0.101 | -3 | 0.761 |
CDK1 |
0.792 | 0.049 | 1 | 0.638 |
JNK2 |
0.792 | 0.091 | 1 | 0.628 |
MASTL |
0.792 | -0.184 | -2 | 0.791 |
CDK8 |
0.792 | 0.017 | 1 | 0.660 |
AKT2 |
0.792 | 0.107 | -3 | 0.716 |
DLK |
0.791 | -0.116 | 1 | 0.813 |
PAK6 |
0.791 | 0.069 | -2 | 0.641 |
RIPK3 |
0.791 | -0.145 | 3 | 0.557 |
TTBK2 |
0.791 | -0.090 | 2 | 0.657 |
SGK3 |
0.791 | 0.112 | -3 | 0.763 |
SIK |
0.791 | 0.054 | -3 | 0.761 |
PLK3 |
0.791 | 0.038 | 2 | 0.740 |
CDK5 |
0.790 | 0.064 | 1 | 0.685 |
PKCB |
0.790 | 0.030 | 2 | 0.644 |
JNK3 |
0.790 | 0.069 | 1 | 0.657 |
NEK9 |
0.789 | -0.122 | 2 | 0.765 |
PKCG |
0.789 | 0.011 | 2 | 0.644 |
DYRK2 |
0.789 | 0.045 | 1 | 0.686 |
DNAPK |
0.789 | 0.044 | 1 | 0.686 |
PKR |
0.788 | 0.025 | 1 | 0.792 |
PKG2 |
0.788 | 0.078 | -2 | 0.662 |
QIK |
0.788 | -0.022 | -3 | 0.816 |
AURB |
0.787 | 0.030 | -2 | 0.611 |
DCAMKL1 |
0.787 | 0.105 | -3 | 0.784 |
MARK2 |
0.787 | 0.047 | 4 | 0.719 |
WNK3 |
0.787 | -0.209 | 1 | 0.774 |
MLK3 |
0.787 | -0.075 | 2 | 0.662 |
ANKRD3 |
0.787 | -0.134 | 1 | 0.828 |
MLK2 |
0.787 | -0.109 | 2 | 0.744 |
GRK2 |
0.786 | 0.019 | -2 | 0.746 |
P38A |
0.786 | 0.061 | 1 | 0.718 |
PAK3 |
0.786 | -0.037 | -2 | 0.716 |
HIPK2 |
0.786 | 0.088 | 1 | 0.598 |
PKCA |
0.786 | 0.005 | 2 | 0.641 |
MNK1 |
0.786 | 0.029 | -2 | 0.750 |
PIM2 |
0.786 | 0.088 | -3 | 0.757 |
CDK19 |
0.786 | 0.017 | 1 | 0.625 |
MELK |
0.785 | 0.015 | -3 | 0.788 |
TLK2 |
0.785 | 0.027 | 1 | 0.747 |
P38B |
0.785 | 0.074 | 1 | 0.663 |
IRE1 |
0.785 | -0.089 | 1 | 0.739 |
CDK13 |
0.785 | 0.016 | 1 | 0.643 |
CDK7 |
0.785 | 0.014 | 1 | 0.669 |
CDK18 |
0.785 | 0.053 | 1 | 0.605 |
BRSK2 |
0.784 | -0.011 | -3 | 0.797 |
AURA |
0.784 | 0.002 | -2 | 0.568 |
CAMK4 |
0.784 | -0.053 | -3 | 0.805 |
HIPK1 |
0.784 | 0.084 | 1 | 0.696 |
CK2A1 |
0.784 | 0.174 | 1 | 0.687 |
MEK1 |
0.784 | -0.101 | 2 | 0.779 |
PHKG1 |
0.783 | -0.016 | -3 | 0.809 |
BRAF |
0.783 | 0.017 | -4 | 0.747 |
PKACA |
0.783 | 0.090 | -2 | 0.603 |
MARK1 |
0.783 | 0.024 | 4 | 0.769 |
P38G |
0.783 | 0.060 | 1 | 0.561 |
MYLK4 |
0.783 | 0.005 | -2 | 0.711 |
ERK1 |
0.783 | 0.044 | 1 | 0.645 |
MLK4 |
0.782 | -0.080 | 2 | 0.647 |
NUAK1 |
0.782 | -0.022 | -3 | 0.785 |
DRAK1 |
0.782 | -0.022 | 1 | 0.780 |
NEK2 |
0.782 | -0.064 | 2 | 0.729 |
CDK3 |
0.782 | 0.048 | 1 | 0.580 |
YSK4 |
0.781 | -0.110 | 1 | 0.762 |
PKCH |
0.781 | -0.019 | 2 | 0.633 |
RIPK1 |
0.781 | -0.203 | 1 | 0.769 |
SSTK |
0.781 | 0.095 | 4 | 0.770 |
CK1E |
0.780 | 0.012 | -3 | 0.581 |
CHK1 |
0.780 | 0.010 | -3 | 0.788 |
PLK4 |
0.780 | -0.053 | 2 | 0.577 |
PKCZ |
0.780 | -0.041 | 2 | 0.686 |
CDK12 |
0.779 | 0.022 | 1 | 0.622 |
GRK3 |
0.779 | 0.036 | -2 | 0.707 |
PASK |
0.779 | 0.051 | -3 | 0.844 |
CHAK1 |
0.778 | -0.108 | 2 | 0.689 |
VRK2 |
0.778 | -0.178 | 1 | 0.824 |
CAMK1G |
0.778 | 0.017 | -3 | 0.771 |
PAK2 |
0.778 | -0.070 | -2 | 0.704 |
SMG1 |
0.777 | -0.074 | 1 | 0.723 |
PERK |
0.777 | -0.045 | -2 | 0.858 |
MST3 |
0.777 | 0.026 | 2 | 0.751 |
CDK9 |
0.777 | -0.001 | 1 | 0.654 |
IRE2 |
0.776 | -0.099 | 2 | 0.636 |
AKT1 |
0.776 | 0.066 | -3 | 0.724 |
DCAMKL2 |
0.776 | 0.040 | -3 | 0.804 |
MEKK3 |
0.775 | -0.119 | 1 | 0.787 |
CDK2 |
0.775 | -0.042 | 1 | 0.715 |
CDK17 |
0.775 | 0.019 | 1 | 0.562 |
DYRK1A |
0.774 | 0.043 | 1 | 0.721 |
P70S6K |
0.774 | 0.048 | -3 | 0.716 |
DYRK4 |
0.774 | 0.047 | 1 | 0.622 |
TAO3 |
0.773 | -0.024 | 1 | 0.779 |
MAK |
0.773 | 0.148 | -2 | 0.701 |
PRP4 |
0.773 | -0.014 | -3 | 0.714 |
CAMK1D |
0.773 | 0.072 | -3 | 0.702 |
CK1G1 |
0.773 | -0.013 | -3 | 0.578 |
MEKK2 |
0.773 | -0.076 | 2 | 0.729 |
MAPKAPK5 |
0.772 | -0.063 | -3 | 0.726 |
ERK2 |
0.772 | -0.012 | 1 | 0.668 |
HIPK3 |
0.772 | 0.031 | 1 | 0.700 |
TLK1 |
0.772 | -0.022 | -2 | 0.847 |
SGK1 |
0.771 | 0.112 | -3 | 0.642 |
ZAK |
0.771 | -0.125 | 1 | 0.771 |
CDK10 |
0.771 | 0.065 | 1 | 0.630 |
MEK5 |
0.771 | -0.199 | 2 | 0.752 |
CK1D |
0.770 | 0.006 | -3 | 0.533 |
NEK5 |
0.770 | -0.081 | 1 | 0.785 |
AKT3 |
0.770 | 0.091 | -3 | 0.660 |
MEKK1 |
0.770 | -0.136 | 1 | 0.777 |
P38D |
0.770 | 0.048 | 1 | 0.565 |
GSK3A |
0.770 | 0.007 | 4 | 0.403 |
PKCT |
0.770 | -0.015 | 2 | 0.641 |
HRI |
0.769 | -0.129 | -2 | 0.865 |
WNK4 |
0.769 | -0.090 | -2 | 0.814 |
CK1A2 |
0.769 | 0.007 | -3 | 0.537 |
PHKG2 |
0.769 | -0.023 | -3 | 0.790 |
JNK1 |
0.769 | 0.042 | 1 | 0.613 |
DYRK1B |
0.769 | 0.031 | 1 | 0.647 |
EEF2K |
0.768 | 0.040 | 3 | 0.688 |
SNRK |
0.768 | -0.167 | 2 | 0.602 |
PINK1 |
0.768 | -0.157 | 1 | 0.763 |
SMMLCK |
0.768 | -0.025 | -3 | 0.813 |
PKCE |
0.768 | 0.036 | 2 | 0.631 |
PAK5 |
0.768 | -0.007 | -2 | 0.579 |
CDK16 |
0.768 | 0.041 | 1 | 0.570 |
CDK14 |
0.768 | 0.020 | 1 | 0.645 |
PLK2 |
0.767 | 0.036 | -3 | 0.781 |
MPSK1 |
0.767 | 0.021 | 1 | 0.719 |
PAK4 |
0.767 | 0.004 | -2 | 0.580 |
DYRK3 |
0.766 | 0.027 | 1 | 0.695 |
PKCI |
0.766 | -0.022 | 2 | 0.649 |
PDK1 |
0.765 | -0.017 | 1 | 0.783 |
IRAK4 |
0.765 | -0.108 | 1 | 0.749 |
DAPK3 |
0.765 | 0.033 | -3 | 0.802 |
GSK3B |
0.765 | -0.037 | 4 | 0.392 |
TNIK |
0.764 | 0.043 | 3 | 0.691 |
GAK |
0.764 | 0.008 | 1 | 0.800 |
TAO2 |
0.763 | -0.063 | 2 | 0.764 |
TTBK1 |
0.763 | -0.149 | 2 | 0.576 |
MRCKB |
0.763 | 0.081 | -3 | 0.742 |
GCK |
0.762 | -0.024 | 1 | 0.793 |
CAMKK2 |
0.762 | -0.086 | -2 | 0.726 |
LKB1 |
0.762 | -0.062 | -3 | 0.787 |
CAMKK1 |
0.761 | -0.131 | -2 | 0.717 |
NEK8 |
0.761 | -0.156 | 2 | 0.725 |
MOK |
0.760 | 0.104 | 1 | 0.715 |
ROCK2 |
0.760 | 0.088 | -3 | 0.779 |
ERK7 |
0.760 | -0.011 | 2 | 0.464 |
DAPK1 |
0.759 | 0.017 | -3 | 0.789 |
MINK |
0.759 | -0.022 | 1 | 0.778 |
HGK |
0.759 | -0.021 | 3 | 0.676 |
SBK |
0.759 | 0.083 | -3 | 0.611 |
HPK1 |
0.759 | -0.005 | 1 | 0.784 |
MST2 |
0.758 | -0.074 | 1 | 0.798 |
NEK11 |
0.758 | -0.174 | 1 | 0.787 |
PKN1 |
0.758 | 0.013 | -3 | 0.735 |
MAP3K15 |
0.757 | -0.070 | 1 | 0.756 |
CAMK1A |
0.757 | 0.052 | -3 | 0.682 |
CHK2 |
0.757 | 0.036 | -3 | 0.668 |
CDK6 |
0.756 | 0.015 | 1 | 0.623 |
KHS2 |
0.756 | 0.042 | 1 | 0.782 |
LRRK2 |
0.755 | -0.095 | 2 | 0.767 |
BUB1 |
0.755 | 0.065 | -5 | 0.731 |
KHS1 |
0.755 | 0.019 | 1 | 0.770 |
TAK1 |
0.755 | -0.094 | 1 | 0.798 |
LOK |
0.755 | -0.035 | -2 | 0.765 |
CDK4 |
0.754 | 0.021 | 1 | 0.603 |
MRCKA |
0.754 | 0.031 | -3 | 0.754 |
NEK4 |
0.754 | -0.134 | 1 | 0.757 |
MEKK6 |
0.753 | -0.088 | 1 | 0.779 |
PBK |
0.753 | 0.019 | 1 | 0.731 |
DMPK1 |
0.752 | 0.089 | -3 | 0.774 |
NEK1 |
0.752 | -0.075 | 1 | 0.762 |
STK33 |
0.752 | -0.124 | 2 | 0.573 |
IRAK1 |
0.751 | -0.260 | -1 | 0.746 |
SLK |
0.750 | -0.082 | -2 | 0.732 |
MST1 |
0.749 | -0.103 | 1 | 0.779 |
CRIK |
0.749 | 0.104 | -3 | 0.722 |
PDHK3_TYR |
0.748 | 0.209 | 4 | 0.840 |
YSK1 |
0.747 | -0.062 | 2 | 0.732 |
PKG1 |
0.747 | 0.030 | -2 | 0.596 |
MEK2 |
0.745 | -0.176 | 2 | 0.745 |
HASPIN |
0.744 | 0.051 | -1 | 0.771 |
ROCK1 |
0.744 | 0.050 | -3 | 0.751 |
VRK1 |
0.743 | -0.186 | 2 | 0.730 |
YANK3 |
0.742 | -0.050 | 2 | 0.381 |
OSR1 |
0.742 | -0.055 | 2 | 0.727 |
TTK |
0.741 | -0.014 | -2 | 0.814 |
CK1A |
0.741 | -0.016 | -3 | 0.453 |
MAP2K4_TYR |
0.739 | 0.069 | -1 | 0.859 |
NEK3 |
0.739 | -0.110 | 1 | 0.734 |
MAP2K6_TYR |
0.738 | 0.060 | -1 | 0.861 |
TESK1_TYR |
0.736 | -0.023 | 3 | 0.700 |
PDHK4_TYR |
0.736 | 0.017 | 2 | 0.813 |
BIKE |
0.735 | 0.008 | 1 | 0.675 |
BMPR2_TYR |
0.735 | 0.029 | -1 | 0.859 |
MAP2K7_TYR |
0.734 | -0.081 | 2 | 0.801 |
EPHA6 |
0.733 | 0.096 | -1 | 0.828 |
ASK1 |
0.733 | -0.116 | 1 | 0.743 |
RIPK2 |
0.733 | -0.302 | 1 | 0.733 |
PDHK1_TYR |
0.733 | -0.026 | -1 | 0.860 |
PKMYT1_TYR |
0.731 | -0.070 | 3 | 0.666 |
MYO3B |
0.731 | -0.080 | 2 | 0.731 |
TAO1 |
0.730 | -0.102 | 1 | 0.710 |
LIMK2_TYR |
0.729 | 0.016 | -3 | 0.844 |
ALPHAK3 |
0.729 | -0.066 | -1 | 0.756 |
PINK1_TYR |
0.729 | -0.129 | 1 | 0.798 |
MYO3A |
0.727 | -0.115 | 1 | 0.745 |
EPHB4 |
0.727 | 0.021 | -1 | 0.810 |
AAK1 |
0.722 | 0.049 | 1 | 0.580 |
RET |
0.722 | -0.129 | 1 | 0.777 |
EPHA4 |
0.721 | 0.008 | 2 | 0.742 |
LIMK1_TYR |
0.721 | -0.148 | 2 | 0.779 |
TXK |
0.720 | 0.048 | 1 | 0.829 |
TYK2 |
0.720 | -0.172 | 1 | 0.778 |
MST1R |
0.719 | -0.167 | 3 | 0.620 |
ABL2 |
0.718 | -0.031 | -1 | 0.754 |
DDR1 |
0.718 | -0.113 | 4 | 0.764 |
ROS1 |
0.718 | -0.134 | 3 | 0.575 |
STLK3 |
0.717 | -0.183 | 1 | 0.731 |
JAK2 |
0.717 | -0.162 | 1 | 0.781 |
FER |
0.717 | -0.081 | 1 | 0.857 |
SRMS |
0.717 | -0.028 | 1 | 0.852 |
TYRO3 |
0.716 | -0.163 | 3 | 0.594 |
EPHB2 |
0.716 | 0.003 | -1 | 0.785 |
EPHB1 |
0.716 | -0.042 | 1 | 0.861 |
INSRR |
0.716 | -0.086 | 3 | 0.551 |
CK1G3 |
0.715 | -0.034 | -3 | 0.413 |
TNK2 |
0.715 | -0.056 | 3 | 0.566 |
CSF1R |
0.714 | -0.152 | 3 | 0.585 |
YES1 |
0.714 | -0.087 | -1 | 0.774 |
EPHB3 |
0.714 | -0.035 | -1 | 0.787 |
FGR |
0.713 | -0.113 | 1 | 0.823 |
JAK3 |
0.713 | -0.123 | 1 | 0.762 |
ABL1 |
0.713 | -0.063 | -1 | 0.742 |
BLK |
0.712 | 0.016 | -1 | 0.767 |
LCK |
0.712 | -0.025 | -1 | 0.760 |
ITK |
0.711 | -0.069 | -1 | 0.745 |
HCK |
0.711 | -0.090 | -1 | 0.760 |
FGFR2 |
0.711 | -0.131 | 3 | 0.595 |
YANK2 |
0.711 | -0.070 | 2 | 0.402 |
TNNI3K_TYR |
0.710 | -0.050 | 1 | 0.779 |
EPHA7 |
0.709 | -0.031 | 2 | 0.734 |
BMX |
0.708 | -0.044 | -1 | 0.670 |
MERTK |
0.708 | -0.093 | 3 | 0.572 |
TNK1 |
0.707 | -0.101 | 3 | 0.582 |
NEK10_TYR |
0.707 | -0.112 | 1 | 0.650 |
KIT |
0.707 | -0.159 | 3 | 0.584 |
PDGFRB |
0.707 | -0.203 | 3 | 0.597 |
FLT3 |
0.707 | -0.175 | 3 | 0.589 |
EPHA3 |
0.707 | -0.090 | 2 | 0.714 |
KDR |
0.706 | -0.149 | 3 | 0.548 |
FYN |
0.706 | -0.019 | -1 | 0.736 |
TEC |
0.705 | -0.085 | -1 | 0.678 |
MET |
0.704 | -0.131 | 3 | 0.580 |
FLT1 |
0.704 | -0.108 | -1 | 0.813 |
JAK1 |
0.704 | -0.131 | 1 | 0.735 |
LTK |
0.703 | -0.126 | 3 | 0.545 |
AXL |
0.703 | -0.160 | 3 | 0.572 |
EPHA5 |
0.703 | -0.025 | 2 | 0.730 |
FGFR1 |
0.703 | -0.189 | 3 | 0.570 |
CK1G2 |
0.703 | -0.023 | -3 | 0.500 |
PTK2 |
0.702 | 0.027 | -1 | 0.774 |
TEK |
0.701 | -0.198 | 3 | 0.530 |
NTRK1 |
0.701 | -0.187 | -1 | 0.786 |
ERBB2 |
0.701 | -0.165 | 1 | 0.751 |
BTK |
0.700 | -0.182 | -1 | 0.706 |
FGFR3 |
0.700 | -0.150 | 3 | 0.569 |
ALK |
0.700 | -0.172 | 3 | 0.521 |
WEE1_TYR |
0.700 | -0.151 | -1 | 0.731 |
FRK |
0.700 | -0.106 | -1 | 0.773 |
SYK |
0.700 | 0.026 | -1 | 0.746 |
EGFR |
0.699 | -0.059 | 1 | 0.667 |
EPHA1 |
0.699 | -0.120 | 3 | 0.569 |
EPHA8 |
0.699 | -0.061 | -1 | 0.763 |
DDR2 |
0.699 | -0.055 | 3 | 0.540 |
LYN |
0.698 | -0.112 | 3 | 0.530 |
INSR |
0.698 | -0.157 | 3 | 0.549 |
PTK2B |
0.698 | -0.080 | -1 | 0.706 |
NTRK3 |
0.696 | -0.144 | -1 | 0.734 |
PDGFRA |
0.695 | -0.299 | 3 | 0.589 |
PTK6 |
0.695 | -0.227 | -1 | 0.672 |
FGFR4 |
0.694 | -0.103 | -1 | 0.733 |
CSK |
0.693 | -0.148 | 2 | 0.735 |
MATK |
0.693 | -0.134 | -1 | 0.695 |
SRC |
0.693 | -0.108 | -1 | 0.725 |
FLT4 |
0.693 | -0.221 | 3 | 0.550 |
NTRK2 |
0.692 | -0.252 | 3 | 0.541 |
EPHA2 |
0.690 | -0.063 | -1 | 0.744 |
IGF1R |
0.686 | -0.138 | 3 | 0.487 |
ERBB4 |
0.685 | -0.066 | 1 | 0.690 |
MUSK |
0.676 | -0.181 | 1 | 0.658 |
ZAP70 |
0.671 | -0.058 | -1 | 0.674 |
FES |
0.669 | -0.164 | -1 | 0.641 |