Motif 938 (n=107)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0C4DFX4 None S2995 ochoa Snf2 related CREBBP activator protein None
A6NKD9 CCDC85C S258 ochoa Coiled-coil domain-containing protein 85C May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.
B2RTY4 MYO9A S40 ochoa Unconventional myosin-IXa (Unconventional myosin-9a) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
O00192 ARVCF S916 ochoa Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}.
O00429 DNM1L S637 psp Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.
O14920 IKBKB S692 ochoa Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}.
O15027 SEC16A S1810 psp Protein transport protein Sec16A (SEC16 homolog A) (p250) Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}.
O43399 TPD52L2 S166 ochoa Tumor protein D54 (hD54) (Tumor protein D52-like 2) None
O60292 SIPA1L3 S207 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O75665 OFD1 S745 ochoa Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O94906 PRPF6 S261 ochoa Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}.
O94916 NFAT5 S248 ochoa Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}.
P01106 MYC S388 psp Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}.
P02671 FGA S22 psp Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P04049 RAF1 S624 ochoa RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P11137 MAP2 S738 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P15924 DSP S246 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P26045 PTPN3 S489 ochoa Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
P29375 KDM5A S225 ochoa|psp Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}.
P39748 FEN1 S351 ochoa Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}.
P41236 PPP1R2 S122 ochoa|psp Protein phosphatase inhibitor 2 (IPP-2) Inhibitor of protein-phosphatase 1.
P42858 HTT S2934 ochoa Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}.
P49685 GPR15 S328 ochoa G-protein coupled receptor 15 (Brother of Bonzo) (BoB) G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660). {ECO:0000250|UniProtKB:Q0VDU3, ECO:0000269|PubMed:33758080, ECO:0000269|PubMed:35510660, ECO:0000269|PubMed:38918398}.; FUNCTION: (Microbial infection) Acts as an alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9791028}.
P49810 PSEN2 S330 psp Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}.
P49815 TSC2 S932 psp Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P50402 EMD S87 ochoa Emerin Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}.
P52565 ARHGDIA S101 ochoa|psp Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.
P78337 PITX1 S46 ochoa Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}.
Q04917 YWHAH S145 ochoa 14-3-3 protein eta (Protein AS1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
Q07912 TNK2 S856 ochoa Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.
Q12929 EPS8 S787 psp Epidermal growth factor receptor kinase substrate 8 Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}.
Q13009 TIAM1 S329 psp Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}.
Q13207 TBX2 S355 ochoa T-box transcription factor TBX2 (T-box protein 2) Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}.
Q13596 SNX1 S25 ochoa Sorting nexin-1 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}.
Q14318 FKBP8 S296 ochoa Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}.
Q14807 KIF22 S455 ochoa Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}.
Q14807 KIF22 S562 ochoa Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}.
Q52LW3 ARHGAP29 S578 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q53HC0 CCDC92 S209 ochoa Coiled-coil domain-containing protein 92 (Limkain beta-2) Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface. {ECO:0000269|PubMed:32528005}.
Q5JSH3 WDR44 S397 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q5JTV8 TOR1AIP1 S179 ochoa Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.
Q5T8P6 RBM26 S589 ochoa RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}.
Q5TH69 ARFGEF3 S1049 ochoa Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}.
Q5VUA4 ZNF318 S1888 ochoa Zinc finger protein 318 (Endocrine regulatory protein) [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.
Q68DK2 ZFYVE26 S703 ochoa Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}.
Q6DN12 MCTP2 S145 ochoa Multiple C2 and transmembrane domain-containing protein 2 Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}.
Q6GQQ9 OTUD7B S776 ochoa OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}.
Q6NV74 CRACDL S609 ochoa CRACD-like protein None
Q6NXS1 PPP1R2B S122 ochoa|psp Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}.
Q6ZN28 MACC1 S34 ochoa Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}.
Q6ZRS2 SRCAP S3172 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q76MJ5 ERN2 S902 ochoa Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}.
Q7RTP6 MICAL3 S1192 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q7Z2W4 ZC3HAV1 S387 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z5L9 IRF2BP2 S243 ochoa Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.
Q8N3D4 EHBP1L1 S993 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8ND56 LSM14A S227 ochoa Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}.
Q8ND76 CCNY S71 ochoa|psp Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.
Q8NFZ4 NLGN2 S718 ochoa Neuroligin-2 Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}.
Q8TBB5 KLHDC4 S413 ochoa Kelch domain-containing protein 4 None
Q8TC05 MDM1 S121 ochoa Nuclear protein MDM1 Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}.
Q8TES7 FBF1 S359 ochoa Fas-binding factor 1 (FBF-1) (Protein albatross) Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}.
Q92552 MRPS27 S301 ochoa Small ribosomal subunit protein mS27 (28S ribosomal protein S27, mitochondrial) (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27) RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366). {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:28714366}.
Q92585 MAML1 S303 ochoa Mastermind-like protein 1 (Mam-1) Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Q92870 APBB2 S407 ochoa Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}.
Q92966 SNAPC3 S74 ochoa snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}.
Q96NE9 FRMD6 S537 ochoa FERM domain-containing protein 6 (Willin) None
Q96PE2 ARHGEF17 S790 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96S59 RANBP9 S176 ochoa Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.
Q99569 PKP4 S77 ochoa Plakophilin-4 (p0071) Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.
Q99759 MAP3K3 S340 ochoa Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}.
Q9BYB0 SHANK3 S891 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BYB0 SHANK3 S1031 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9C0C2 TNKS1BP1 S592 ochoa 182 kDa tankyrase-1-binding protein None
Q9H1K1 ISCU S29 ochoa Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}.
Q9H9J4 USP42 S754 ochoa Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.
Q9HCC0 MCCC2 S499 ochoa Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}.
Q9HCK8 CHD8 S1976 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9NWQ4 GPATCH2L S137 ochoa G patch domain-containing protein 2-like None
Q9NXR1 NDE1 S282 ochoa|psp Nuclear distribution protein nudE homolog 1 (NudE) Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}.
Q9NYL2 MAP3K20 S362 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9P2N5 RBM27 S657 ochoa RNA-binding protein 27 (RNA-binding motif protein 27) May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}.
Q9UGU5 HMGXB4 S387 ochoa HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}.
Q9UGY1 NOL12 S134 ochoa Nucleolar protein 12 Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}.
Q9UHB6 LIMA1 S343 ochoa LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9UHR6 ZNHIT2 S165 ochoa Zinc finger HIT domain-containing protein 2 (Protein FON) May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:28561026}.
Q9UJ70 NAGK S76 ochoa N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}.
Q9ULH0 KIDINS220 S1295 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9UPQ0 LIMCH1 S226 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9Y343 SNX24 S116 ochoa Sorting nexin-24 May be involved in several stages of intracellular trafficking. {ECO:0000250}.
Q9Y3M8 STARD13 S457 ochoa StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}.
Q9Y448 KNSTRN S232 ochoa Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}.
Q9Y5J1 UTP18 S121 ochoa U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}.
U3KPZ7 LOC127814297 S602 ochoa RNA-binding protein 27 (RNA-binding motif protein 27) May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}.
V9GYY5 None S127 ochoa Nucleolar protein 12 Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}.
P61604 HSPE1 S21 Sugiyama 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}.
P20674 COX5A S104 Sugiyama Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00427}.
Q9Y6A5 TACC3 S552 SIGNOR Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
P53621 COPA S389 Sugiyama Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.
P21802 FGFR2 S587 Sugiyama Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.
Q9Y4W2 LAS1L S636 Sugiyama Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}.
Q14697 GANAB S169 Sugiyama Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}.
Q9NPD3 EXOSC4 S77 Sugiyama Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}.
P35613 BSG S228 Sugiyama Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}.
Q96J92 WNK4 S130 Sugiyama Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}.
Q9BYP7 WNK3 S44 Sugiyama Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}.
P36578 RPL4 S139 Sugiyama Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
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reactome_id name p -log10_p
R-HSA-8851708 Signaling by FGFR2 IIIa TM 1.072350e-06 5.970
R-HSA-1839126 FGFR2 mutant receptor activation 8.798568e-07 6.056
R-HSA-5655253 Signaling by FGFR2 in disease 4.850890e-06 5.314
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 3.744186e-05 4.427
R-HSA-190241 FGFR2 ligand binding and activation 4.355763e-05 4.361
R-HSA-1226099 Signaling by FGFR in disease 3.364149e-05 4.473
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 3.752734e-05 4.426
R-HSA-5654695 PI-3K cascade:FGFR2 8.560365e-05 4.068
R-HSA-5654699 SHC-mediated cascade:FGFR2 1.087062e-04 3.964
R-HSA-5654700 FRS-mediated FGFR2 signaling 1.218124e-04 3.914
R-HSA-5654727 Negative regulation of FGFR2 signaling 2.477226e-04 3.606
R-HSA-5654696 Downstream signaling of activated FGFR2 2.712741e-04 3.567
R-HSA-5683057 MAPK family signaling cascades 3.674892e-04 3.435
R-HSA-2023837 Signaling by FGFR2 amplification mutants 6.388753e-04 3.195
R-HSA-2033519 Activated point mutants of FGFR2 6.711281e-04 3.173
R-HSA-109704 PI3K Cascade 9.025813e-04 3.045
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 1.613340e-03 2.792
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1.613340e-03 2.792
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1.613340e-03 2.792
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 1.613340e-03 2.792
R-HSA-2644603 Signaling by NOTCH1 in Cancer 1.613340e-03 2.792
R-HSA-193704 p75 NTR receptor-mediated signalling 1.322906e-03 2.878
R-HSA-73887 Death Receptor Signaling 1.692700e-03 2.771
R-HSA-112399 IRS-mediated signalling 1.369505e-03 2.863
R-HSA-2428928 IRS-related events triggered by IGF1R 1.700908e-03 2.769
R-HSA-5673001 RAF/MAP kinase cascade 1.969666e-03 2.706
R-HSA-2428924 IGF1R signaling cascade 1.983355e-03 2.703
R-HSA-74751 Insulin receptor signalling cascade 1.983355e-03 2.703
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 2.084291e-03 2.681
R-HSA-5684996 MAPK1/MAPK3 signaling 2.260123e-03 2.646
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 2.495631e-03 2.603
R-HSA-8951430 RUNX3 regulates WNT signaling 2.495631e-03 2.603
R-HSA-2219528 PI3K/AKT Signaling in Cancer 2.903419e-03 2.537
R-HSA-162582 Signal Transduction 2.805285e-03 2.552
R-HSA-9930044 Nuclear RNA decay 3.008003e-03 2.522
R-HSA-1980143 Signaling by NOTCH1 3.438567e-03 2.464
R-HSA-5654738 Signaling by FGFR2 4.051391e-03 2.392
R-HSA-190377 FGFR2b ligand binding and activation 4.799772e-03 2.319
R-HSA-4641265 Repression of WNT target genes 6.210170e-03 2.207
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 6.630204e-03 2.178
R-HSA-190375 FGFR2c ligand binding and activation 6.977704e-03 2.156
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 7.236737e-03 2.140
R-HSA-74752 Signaling by Insulin receptor 6.769954e-03 2.169
R-HSA-190236 Signaling by FGFR 8.495438e-03 2.071
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 8.547381e-03 2.068
R-HSA-9012852 Signaling by NOTCH3 1.118561e-02 1.951
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.264508e-02 1.898
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.652158e-02 1.782
R-HSA-8868773 rRNA processing in the nucleus and cytosol 1.800475e-02 1.745
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 1.797509e-02 1.745
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1.818897e-02 1.740
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 1.679262e-02 1.775
R-HSA-8853333 Signaling by FGFR2 fusions 2.156333e-02 1.666
R-HSA-5602636 IKBKB deficiency causes SCID 2.156333e-02 1.666
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 2.156333e-02 1.666
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 2.165463e-02 1.664
R-HSA-199418 Negative regulation of the PI3K/AKT network 2.185058e-02 1.661
R-HSA-9013694 Signaling by NOTCH4 2.235076e-02 1.651
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 2.439050e-02 1.613
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 2.439050e-02 1.613
R-HSA-6802957 Oncogenic MAPK signaling 3.080769e-02 1.511
R-HSA-209563 Axonal growth stimulation 3.568211e-02 1.448
R-HSA-9909438 3-Methylcrotonyl-CoA carboxylase deficiency 3.568211e-02 1.448
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 3.603436e-02 1.443
R-HSA-1980145 Signaling by NOTCH2 3.627125e-02 1.440
R-HSA-165181 Inhibition of TSC complex formation by PKB 4.266556e-02 1.370
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 4.266556e-02 1.370
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 4.119510e-02 1.385
R-HSA-157118 Signaling by NOTCH 4.182396e-02 1.379
R-HSA-72312 rRNA processing 3.740670e-02 1.427
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 4.119510e-02 1.385
R-HSA-5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) 6.331649e-02 1.198
R-HSA-9732724 IFNG signaling activates MAPKs 7.010150e-02 1.154
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 7.010150e-02 1.154
R-HSA-9660537 Signaling by MRAS-complex mutants 7.683778e-02 1.114
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 7.683778e-02 1.114
R-HSA-170984 ARMS-mediated activation 8.352567e-02 1.078
R-HSA-433692 Proton-coupled monocarboxylate transport 1.033025e-01 0.986
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1.098003e-01 0.959
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 1.353278e-01 0.869
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 1.478181e-01 0.830
R-HSA-9656223 Signaling by RAF1 mutants 4.991893e-02 1.302
R-HSA-210991 Basigin interactions 1.722645e-01 0.764
R-HSA-5602498 MyD88 deficiency (TLR2/4) 1.722645e-01 0.764
R-HSA-9649948 Signaling downstream of RAS mutants 5.924117e-02 1.227
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 1.782666e-01 0.749
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1.842256e-01 0.735
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 9.472267e-02 1.024
R-HSA-380259 Loss of Nlp from mitotic centrosomes 9.472267e-02 1.024
R-HSA-8854518 AURKA Activation by TPX2 1.014975e-01 0.994
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.177965e-01 0.929
R-HSA-380287 Centrosome maturation 1.225684e-01 0.912
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.571541e-01 0.804
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 2.303805e-01 0.638
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 1.722645e-01 0.764
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 5.924117e-02 1.227
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 5.924117e-02 1.227
R-HSA-5674135 MAP2K and MAPK activation 4.991893e-02 1.302
R-HSA-6802949 Signaling by RAS mutants 5.924117e-02 1.227
R-HSA-8941856 RUNX3 regulates NOTCH signaling 1.098003e-01 0.959
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 1.662188e-01 0.779
R-HSA-5673000 RAF activation 2.579025e-01 0.589
R-HSA-354192 Integrin signaling 2.470128e-01 0.607
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 4.812455e-02 1.318
R-HSA-9758274 Regulation of NF-kappa B signaling 1.353278e-01 0.869
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.828525e-01 0.738
R-HSA-5603029 IkBA variant leads to EDA-ID 5.648240e-02 1.248
R-HSA-9017802 Noncanonical activation of NOTCH3 5.648240e-02 1.248
R-HSA-9032845 Activated NTRK2 signals through CDK5 7.010150e-02 1.154
R-HSA-193697 p75NTR regulates axonogenesis 8.352567e-02 1.078
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.033025e-01 0.986
R-HSA-209560 NF-kB is activated and signals survival 1.033025e-01 0.986
R-HSA-380615 Serotonin clearance from the synaptic cleft 1.098003e-01 0.959
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 1.162514e-01 0.935
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 1.226561e-01 0.911
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 1.290148e-01 0.889
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.539960e-01 0.812
R-HSA-350054 Notch-HLH transcription pathway 1.842256e-01 0.735
R-HSA-933542 TRAF6 mediated NF-kB activation 1.960153e-01 0.708
R-HSA-5675221 Negative regulation of MAPK pathway 4.991893e-02 1.302
R-HSA-5260271 Diseases of Immune System 4.635452e-02 1.334
R-HSA-5602358 Diseases associated with the TLR signaling cascade 4.635452e-02 1.334
R-HSA-6794361 Neurexins and neuroligins 7.114331e-02 1.148
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.076361e-01 0.683
R-HSA-111447 Activation of BAD and translocation to mitochondria 1.290148e-01 0.889
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 2.518077e-01 0.599
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 2.518077e-01 0.599
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 2.598570e-01 0.585
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 2.598570e-01 0.585
R-HSA-5674499 Negative feedback regulation of MAPK pathway 5.648240e-02 1.248
R-HSA-193634 Axonal growth inhibition (RHOA activation) 7.683778e-02 1.114
R-HSA-9839383 TGFBR3 PTM regulation 7.683778e-02 1.114
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 9.016553e-02 1.045
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 1.290148e-01 0.889
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 1.601295e-01 0.796
R-HSA-937041 IKK complex recruitment mediated by RIP1 1.601295e-01 0.796
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 1.662188e-01 0.779
R-HSA-5357786 TNFR1-induced proapoptotic signaling 1.722645e-01 0.764
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 6.117271e-02 1.213
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.445871e-01 0.840
R-HSA-169893 Prolonged ERK activation events 1.353278e-01 0.869
R-HSA-76046 RNA Polymerase III Transcription Initiation 2.303805e-01 0.638
R-HSA-9818749 Regulation of NFE2L2 gene expression 6.331649e-02 1.198
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 2.303805e-01 0.638
R-HSA-5621575 CD209 (DC-SIGN) signaling 1.960153e-01 0.708
R-HSA-9020702 Interleukin-1 signaling 1.959262e-01 0.708
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 7.010150e-02 1.154
R-HSA-9683686 Maturation of spike protein 9.016553e-02 1.045
R-HSA-937039 IRAK1 recruits IKK complex 1.098003e-01 0.959
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.098003e-01 0.959
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 1.226561e-01 0.911
R-HSA-69166 Removal of the Flap Intermediate 1.226561e-01 0.911
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.290148e-01 0.889
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 1.353278e-01 0.869
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 1.478181e-01 0.830
R-HSA-429947 Deadenylation of mRNA 1.960153e-01 0.708
R-HSA-6794362 Protein-protein interactions at synapses 1.470832e-01 0.832
R-HSA-196780 Biotin transport and metabolism 1.290148e-01 0.889
R-HSA-193639 p75NTR signals via NF-kB 1.290148e-01 0.889
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 8.374497e-02 1.077
R-HSA-430116 GP1b-IX-V activation signalling 8.352567e-02 1.078
R-HSA-5628897 TP53 Regulates Metabolic Genes 6.715814e-02 1.173
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 8.352567e-02 1.078
R-HSA-193692 Regulated proteolysis of p75NTR 8.352567e-02 1.078
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 9.675769e-02 1.014
R-HSA-8851805 MET activates RAS signaling 1.098003e-01 0.959
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.162514e-01 0.935
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 1.290148e-01 0.889
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 1.353278e-01 0.869
R-HSA-429914 Deadenylation-dependent mRNA decay 8.590754e-02 1.066
R-HSA-187687 Signalling to ERKs 2.632887e-01 0.580
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 1.539960e-01 0.812
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.107315e-01 0.956
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 5.648240e-02 1.248
R-HSA-3323169 Defects in biotin (Btn) metabolism 8.352567e-02 1.078
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.290148e-01 0.889
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 1.478181e-01 0.830
R-HSA-4419969 Depolymerization of the Nuclear Lamina 1.539960e-01 0.812
R-HSA-5617833 Cilium Assembly 1.950191e-01 0.710
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 1.722645e-01 0.764
R-HSA-8953854 Metabolism of RNA 9.404189e-02 1.027
R-HSA-8878159 Transcriptional regulation by RUNX3 4.467239e-02 1.350
R-HSA-9616222 Transcriptional regulation of granulopoiesis 9.249486e-02 1.034
R-HSA-205043 NRIF signals cell death from the nucleus 1.226561e-01 0.911
R-HSA-69183 Processive synthesis on the lagging strand 1.290148e-01 0.889
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 1.290148e-01 0.889
R-HSA-392517 Rap1 signalling 1.601295e-01 0.796
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 1.782666e-01 0.749
R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 1.901417e-01 0.721
R-HSA-193648 NRAGE signals death through JNK 7.947176e-02 1.100
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 2.076361e-01 0.683
R-HSA-174414 Processive synthesis on the C-strand of the telomere 2.133839e-01 0.671
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 2.190904e-01 0.659
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 2.524773e-01 0.598
R-HSA-140875 Common Pathway of Fibrin Clot Formation 1.662188e-01 0.779
R-HSA-112311 Neurotransmitter clearance 2.303805e-01 0.638
R-HSA-5689880 Ub-specific processing proteases 5.208443e-02 1.283
R-HSA-75893 TNF signaling 7.947176e-02 1.100
R-HSA-3214842 HDMs demethylate histones 2.018467e-01 0.695
R-HSA-209543 p75NTR recruits signalling complexes 1.098003e-01 0.959
R-HSA-198323 AKT phosphorylates targets in the cytosol 1.098003e-01 0.959
R-HSA-9816359 Maternal to zygotic transition (MZT) 7.866951e-02 1.104
R-HSA-2682334 EPH-Ephrin signaling 1.699191e-01 0.770
R-HSA-114452 Activation of BH3-only proteins 2.303805e-01 0.638
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 7.683778e-02 1.114
R-HSA-9842663 Signaling by LTK 1.098003e-01 0.959
R-HSA-9865881 Complex III assembly 1.960153e-01 0.708
R-HSA-5357905 Regulation of TNFR1 signaling 5.924117e-02 1.227
R-HSA-69186 Lagging Strand Synthesis 1.722645e-01 0.764
R-HSA-9865118 Diseases of branched-chain amino acid catabolism 2.076361e-01 0.683
R-HSA-381042 PERK regulates gene expression 2.632887e-01 0.580
R-HSA-1236974 ER-Phagosome pathway 1.596922e-01 0.797
R-HSA-5688426 Deubiquitination 5.092704e-02 1.293
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 2.632887e-01 0.580
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 1.662188e-01 0.779
R-HSA-9006115 Signaling by NTRK2 (TRKB) 2.133839e-01 0.671
R-HSA-5686938 Regulation of TLR by endogenous ligand 2.579025e-01 0.589
R-HSA-901042 Calnexin/calreticulin cycle 2.579025e-01 0.589
R-HSA-5687128 MAPK6/MAPK4 signaling 1.470832e-01 0.832
R-HSA-4086398 Ca2+ pathway 1.177965e-01 0.929
R-HSA-216083 Integrin cell surface interactions 1.298131e-01 0.887
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.842256e-01 0.735
R-HSA-9022692 Regulation of MECP2 expression and activity 2.470128e-01 0.607
R-HSA-69190 DNA strand elongation 2.415087e-01 0.617
R-HSA-416482 G alpha (12/13) signalling events 1.298131e-01 0.887
R-HSA-195721 Signaling by WNT 2.013738e-01 0.696
R-HSA-201681 TCF dependent signaling in response to WNT 1.822433e-01 0.739
R-HSA-9694301 Maturation of replicase proteins 7.010150e-02 1.154
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 1.901417e-01 0.721
R-HSA-168638 NOD1/2 Signaling Pathway 2.579025e-01 0.589
R-HSA-3296482 Defects in vitamin and cofactor metabolism 2.632887e-01 0.580
R-HSA-182971 EGFR downregulation 2.359646e-01 0.627
R-HSA-1236975 Antigen processing-Cross presentation 2.170716e-01 0.663
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 7.947176e-02 1.100
R-HSA-1538133 G0 and Early G1 2.415087e-01 0.617
R-HSA-75153 Apoptotic execution phase 5.924117e-02 1.227
R-HSA-2672351 Stimuli-sensing channels 5.763573e-02 1.239
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 1.842256e-01 0.735
R-HSA-109581 Apoptosis 1.437892e-01 0.842
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.415087e-01 0.617
R-HSA-162594 Early Phase of HIV Life Cycle 1.722645e-01 0.764
R-HSA-1257604 PIP3 activates AKT signaling 8.046997e-02 1.094
R-HSA-5357801 Programmed Cell Death 2.249925e-01 0.648
R-HSA-9006936 Signaling by TGFB family members 1.404404e-01 0.853
R-HSA-170834 Signaling by TGF-beta Receptor Complex 1.854568e-01 0.732
R-HSA-983712 Ion channel transport 1.931801e-01 0.714
R-HSA-9730414 MITF-M-regulated melanocyte development 2.403098e-01 0.619
R-HSA-9006925 Intracellular signaling by second messengers 1.246280e-01 0.904
R-HSA-6809371 Formation of the cornified envelope 2.652254e-01 0.576
R-HSA-74158 RNA Polymerase III Transcription 2.686361e-01 0.571
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 2.686361e-01 0.571
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 2.686361e-01 0.571
R-HSA-8853659 RET signaling 2.686361e-01 0.571
R-HSA-5689896 Ovarian tumor domain proteases 2.739450e-01 0.562
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.739450e-01 0.562
R-HSA-9694516 SARS-CoV-2 Infection 2.809061e-01 0.551
R-HSA-201556 Signaling by ALK 2.844485e-01 0.546
R-HSA-9604323 Negative regulation of NOTCH4 signaling 2.896436e-01 0.538
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 2.896436e-01 0.538
R-HSA-1251985 Nuclear signaling by ERBB4 2.896436e-01 0.538
R-HSA-8856688 Golgi-to-ER retrograde transport 2.920528e-01 0.535
R-HSA-73933 Resolution of Abasic Sites (AP sites) 2.948013e-01 0.530
R-HSA-9694548 Maturation of spike protein 2.948013e-01 0.530
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 2.948013e-01 0.530
R-HSA-442660 SLC-mediated transport of neurotransmitters 2.999219e-01 0.523
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 2.999219e-01 0.523
R-HSA-9683701 Translation of Structural Proteins 2.999219e-01 0.523
R-HSA-165159 MTOR signalling 3.050056e-01 0.516
R-HSA-9018519 Estrogen-dependent gene expression 3.054293e-01 0.515
R-HSA-3858494 Beta-catenin independent WNT signaling 3.054293e-01 0.515
R-HSA-8854214 TBC/RABGAPs 3.100527e-01 0.509
R-HSA-381119 Unfolded Protein Response (UPR) 3.134345e-01 0.504
R-HSA-3928662 EPHB-mediated forward signaling 3.150635e-01 0.502
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3.150635e-01 0.502
R-HSA-76009 Platelet Aggregation (Plug Formation) 3.200382e-01 0.495
R-HSA-72165 mRNA Splicing - Minor Pathway 3.249770e-01 0.488
R-HSA-9861718 Regulation of pyruvate metabolism 3.249770e-01 0.488
R-HSA-9839373 Signaling by TGFBR3 3.249770e-01 0.488
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 3.298803e-01 0.482
R-HSA-199977 ER to Golgi Anterograde Transport 3.373236e-01 0.472
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 3.395812e-01 0.469
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 3.399640e-01 0.469
R-HSA-166520 Signaling by NTRKs 3.399640e-01 0.469
R-HSA-69242 S Phase 3.399640e-01 0.469
R-HSA-9856651 MITF-M-dependent gene expression 3.452353e-01 0.462
R-HSA-9864848 Complex IV assembly 3.491429e-01 0.457
R-HSA-1169091 Activation of NF-kappaB in B cells 3.491429e-01 0.457
R-HSA-70895 Branched-chain amino acid catabolism 3.491429e-01 0.457
R-HSA-446652 Interleukin-1 family signaling 3.504932e-01 0.455
R-HSA-1266738 Developmental Biology 3.555952e-01 0.449
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.585672e-01 0.445
R-HSA-199991 Membrane Trafficking 3.590754e-01 0.445
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 3.724507e-01 0.429
R-HSA-109606 Intrinsic Pathway for Apoptosis 3.724507e-01 0.429
R-HSA-177929 Signaling by EGFR 3.724507e-01 0.429
R-HSA-2980766 Nuclear Envelope Breakdown 3.770120e-01 0.424
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 3.770120e-01 0.424
R-HSA-9772572 Early SARS-CoV-2 Infection Events 3.815404e-01 0.418
R-HSA-186712 Regulation of beta-cell development 3.860362e-01 0.413
R-HSA-180786 Extension of Telomeres 3.860362e-01 0.413
R-HSA-983189 Kinesins 3.904995e-01 0.408
R-HSA-422475 Axon guidance 3.934867e-01 0.405
R-HSA-9793380 Formation of paraxial mesoderm 3.949307e-01 0.403
R-HSA-450294 MAP kinase activation 3.949307e-01 0.403
R-HSA-5621481 C-type lectin receptors (CLRs) 4.021953e-01 0.396
R-HSA-446203 Asparagine N-linked glycosylation 4.023139e-01 0.395
R-HSA-6790901 rRNA modification in the nucleus and cytosol 4.036975e-01 0.394
R-HSA-9764265 Regulation of CDH1 Expression and Function 4.072647e-01 0.390
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 4.072647e-01 0.390
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 4.080336e-01 0.389
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 4.123137e-01 0.385
R-HSA-9678108 SARS-CoV-1 Infection 4.123137e-01 0.385
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 4.166121e-01 0.380
R-HSA-1643685 Disease 4.168514e-01 0.380
R-HSA-611105 Respiratory electron transport 4.198479e-01 0.377
R-HSA-69278 Cell Cycle, Mitotic 4.237263e-01 0.373
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 4.250674e-01 0.372
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 4.334011e-01 0.363
R-HSA-204005 COPII-mediated vesicle transport 4.334011e-01 0.363
R-HSA-69202 Cyclin E associated events during G1/S transition 4.334011e-01 0.363
R-HSA-448424 Interleukin-17 signaling 4.334011e-01 0.363
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 4.334011e-01 0.363
R-HSA-1640170 Cell Cycle 4.371350e-01 0.359
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 4.375230e-01 0.359
R-HSA-69275 G2/M Transition 4.396980e-01 0.357
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.416151e-01 0.355
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 4.416151e-01 0.355
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 4.416151e-01 0.355
R-HSA-453274 Mitotic G2-G2/M phases 4.446036e-01 0.352
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 4.456777e-01 0.351
R-HSA-9749641 Aspirin ADME 4.456777e-01 0.351
R-HSA-9675108 Nervous system development 4.466034e-01 0.350
R-HSA-69473 G2/M DNA damage checkpoint 4.497110e-01 0.347
R-HSA-1236394 Signaling by ERBB4 4.497110e-01 0.347
R-HSA-1852241 Organelle biogenesis and maintenance 4.498510e-01 0.347
R-HSA-168898 Toll-like Receptor Cascades 4.519177e-01 0.345
R-HSA-71403 Citric acid cycle (TCA cycle) 4.537152e-01 0.343
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 4.543438e-01 0.343
R-HSA-68877 Mitotic Prometaphase 4.567638e-01 0.340
R-HSA-9694635 Translation of Structural Proteins 4.616372e-01 0.336
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 4.639872e-01 0.333
R-HSA-9955298 SLC-mediated transport of organic anions 4.655553e-01 0.332
R-HSA-9659379 Sensory processing of sound 4.694452e-01 0.328
R-HSA-3700989 Transcriptional Regulation by TP53 4.718180e-01 0.326
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.733070e-01 0.325
R-HSA-6806834 Signaling by MET 4.733070e-01 0.325
R-HSA-9833482 PKR-mediated signaling 4.733070e-01 0.325
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 4.735314e-01 0.325
R-HSA-977225 Amyloid fiber formation 4.771409e-01 0.321
R-HSA-948021 Transport to the Golgi and subsequent modification 4.782656e-01 0.320
R-HSA-9707564 Cytoprotection by HMOX1 4.847260e-01 0.315
R-HSA-1428517 Aerobic respiration and respiratory electron transport 4.890738e-01 0.311
R-HSA-6805567 Keratinization 4.899882e-01 0.310
R-HSA-141424 Amplification of signal from the kinetochores 4.958995e-01 0.305
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 4.958995e-01 0.305
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 4.995703e-01 0.301
R-HSA-70268 Pyruvate metabolism 5.032146e-01 0.298
R-HSA-156902 Peptide chain elongation 5.068327e-01 0.295
R-HSA-68882 Mitotic Anaphase 5.129382e-01 0.290
R-HSA-202424 Downstream TCR signaling 5.139905e-01 0.289
R-HSA-73884 Base Excision Repair 5.139905e-01 0.289
R-HSA-2555396 Mitotic Metaphase and Anaphase 5.151961e-01 0.288
R-HSA-418990 Adherens junctions interactions 5.174472e-01 0.286
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 5.175307e-01 0.286
R-HSA-1912408 Pre-NOTCH Transcription and Translation 5.175307e-01 0.286
R-HSA-8986944 Transcriptional Regulation by MECP2 5.175307e-01 0.286
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 5.210454e-01 0.283
R-HSA-381070 IRE1alpha activates chaperones 5.210454e-01 0.283
R-HSA-156842 Eukaryotic Translation Elongation 5.245346e-01 0.280
R-HSA-9772573 Late SARS-CoV-2 Infection Events 5.245346e-01 0.280
R-HSA-9837999 Mitochondrial protein degradation 5.314377e-01 0.275
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 5.348519e-01 0.272
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.348519e-01 0.272
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 5.382414e-01 0.269
R-HSA-72764 Eukaryotic Translation Termination 5.382414e-01 0.269
R-HSA-72689 Formation of a pool of free 40S subunits 5.382414e-01 0.269
R-HSA-9705683 SARS-CoV-2-host interactions 5.395785e-01 0.268
R-HSA-5389840 Mitochondrial translation elongation 5.416065e-01 0.266
R-HSA-6807878 COPI-mediated anterograde transport 5.416065e-01 0.266
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.416065e-01 0.266
R-HSA-157579 Telomere Maintenance 5.449472e-01 0.264
R-HSA-8957275 Post-translational protein phosphorylation 5.482637e-01 0.261
R-HSA-5368286 Mitochondrial translation initiation 5.482637e-01 0.261
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.482637e-01 0.261
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.482637e-01 0.261
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.482637e-01 0.261
R-HSA-69618 Mitotic Spindle Checkpoint 5.548252e-01 0.256
R-HSA-5610787 Hedgehog 'off' state 5.548252e-01 0.256
R-HSA-2408557 Selenocysteine synthesis 5.580703e-01 0.253
R-HSA-8939211 ESR-mediated signaling 5.588976e-01 0.253
R-HSA-5653656 Vesicle-mediated transport 5.623936e-01 0.250
R-HSA-68886 M Phase 5.632064e-01 0.249
R-HSA-192823 Viral mRNA Translation 5.644905e-01 0.248
R-HSA-9937383 Mitochondrial ribosome-associated quality control 5.644905e-01 0.248
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 5.676658e-01 0.246
R-HSA-9860931 Response of endothelial cells to shear stress 5.676658e-01 0.246
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 5.739478e-01 0.241
R-HSA-9692914 SARS-CoV-1-host interactions 5.770547e-01 0.239
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.801392e-01 0.236
R-HSA-69239 Synthesis of DNA 5.801392e-01 0.236
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 5.832014e-01 0.234
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 5.832014e-01 0.234
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 5.832014e-01 0.234
R-HSA-5419276 Mitochondrial translation termination 5.862414e-01 0.232
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 5.862414e-01 0.232
R-HSA-975155 MyD88 dependent cascade initiated on endosome 5.862414e-01 0.232
R-HSA-421270 Cell-cell junction organization 5.878020e-01 0.231
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 5.892595e-01 0.230
R-HSA-166166 MyD88-independent TLR4 cascade 5.892595e-01 0.230
R-HSA-202403 TCR signaling 5.892595e-01 0.230
R-HSA-927802 Nonsense-Mediated Decay (NMD) 5.952303e-01 0.225
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5.952303e-01 0.225
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 5.981833e-01 0.223
R-HSA-1912422 Pre-NOTCH Expression and Processing 5.981833e-01 0.223
R-HSA-9855142 Cellular responses to mechanical stimuli 6.011150e-01 0.221
R-HSA-69620 Cell Cycle Checkpoints 6.017259e-01 0.221
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 6.040254e-01 0.219
R-HSA-9679506 SARS-CoV Infections 6.058437e-01 0.218
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 6.069148e-01 0.217
R-HSA-72613 Eukaryotic Translation Initiation 6.126311e-01 0.213
R-HSA-72737 Cap-dependent Translation Initiation 6.126311e-01 0.213
R-HSA-373760 L1CAM interactions 6.126311e-01 0.213
R-HSA-9007101 Rab regulation of trafficking 6.154582e-01 0.211
R-HSA-8953897 Cellular responses to stimuli 6.179860e-01 0.209
R-HSA-5693538 Homology Directed Repair 6.182649e-01 0.209
R-HSA-9711123 Cellular response to chemical stress 6.210048e-01 0.207
R-HSA-68875 Mitotic Prophase 6.238175e-01 0.205
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.265637e-01 0.203
R-HSA-73886 Chromosome Maintenance 6.265637e-01 0.203
R-HSA-9759194 Nuclear events mediated by NFE2L2 6.265637e-01 0.203
R-HSA-2132295 MHC class II antigen presentation 6.319966e-01 0.199
R-HSA-76002 Platelet activation, signaling and aggregation 6.322270e-01 0.199
R-HSA-2262752 Cellular responses to stress 6.355486e-01 0.197
R-HSA-446728 Cell junction organization 6.395652e-01 0.194
R-HSA-69206 G1/S Transition 6.399993e-01 0.194
R-HSA-114608 Platelet degranulation 6.452384e-01 0.190
R-HSA-69481 G2/M Checkpoints 6.452384e-01 0.190
R-HSA-187037 Signaling by NTRK1 (TRKA) 6.478295e-01 0.189
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 6.580076e-01 0.182
R-HSA-1474228 Degradation of the extracellular matrix 6.605062e-01 0.180
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 6.629867e-01 0.178
R-HSA-9948299 Ribosome-associated quality control 6.774970e-01 0.169
R-HSA-5368287 Mitochondrial translation 6.774970e-01 0.169
R-HSA-5358351 Signaling by Hedgehog 6.774970e-01 0.169
R-HSA-1632852 Macroautophagy 6.845181e-01 0.165
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 6.891144e-01 0.162
R-HSA-112316 Neuronal System 6.931598e-01 0.159
R-HSA-2871837 FCERI mediated NF-kB activation 6.936443e-01 0.159
R-HSA-449147 Signaling by Interleukins 6.947875e-01 0.158
R-HSA-453279 Mitotic G1 phase and G1/S transition 6.981088e-01 0.156
R-HSA-109582 Hemostasis 7.008809e-01 0.154
R-HSA-1500931 Cell-Cell communication 7.036649e-01 0.153
R-HSA-9758941 Gastrulation 7.046848e-01 0.152
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.089897e-01 0.149
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 7.111188e-01 0.148
R-HSA-9609507 Protein localization 7.132324e-01 0.147
R-HSA-5693532 DNA Double-Strand Break Repair 7.132324e-01 0.147
R-HSA-69306 DNA Replication 7.132324e-01 0.147
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 7.153307e-01 0.145
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.174138e-01 0.144
R-HSA-9612973 Autophagy 7.194817e-01 0.143
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 7.215347e-01 0.142
R-HSA-162587 HIV Life Cycle 7.215347e-01 0.142
R-HSA-9711097 Cellular response to starvation 7.235727e-01 0.141
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 7.235727e-01 0.141
R-HSA-877300 Interferon gamma signaling 7.255960e-01 0.139
R-HSA-1474244 Extracellular matrix organization 7.262587e-01 0.139
R-HSA-2467813 Separation of Sister Chromatids 7.354941e-01 0.133
R-HSA-2408522 Selenoamino acid metabolism 7.354941e-01 0.133
R-HSA-5619102 SLC transporter disorders 7.412623e-01 0.130
R-HSA-418555 G alpha (s) signalling events 7.505999e-01 0.125
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.524270e-01 0.124
R-HSA-168255 Influenza Infection 7.648500e-01 0.116
R-HSA-9006931 Signaling by Nuclear Receptors 7.696555e-01 0.114
R-HSA-72163 mRNA Splicing - Major Pathway 7.894277e-01 0.103
R-HSA-597592 Post-translational protein modification 7.897712e-01 0.102
R-HSA-913531 Interferon Signaling 7.948039e-01 0.100
R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.948039e-01 0.100
R-HSA-389948 Co-inhibition by PD-1 7.985297e-01 0.098
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 8.029333e-01 0.095
R-HSA-376176 Signaling by ROBO receptors 8.029333e-01 0.095
R-HSA-72172 mRNA Splicing 8.058159e-01 0.094
R-HSA-425407 SLC-mediated transmembrane transport 8.102062e-01 0.091
R-HSA-9748784 Drug ADME 8.248564e-01 0.084
R-HSA-162906 HIV Infection 8.361069e-01 0.078
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.396954e-01 0.076
R-HSA-72766 Translation 8.416329e-01 0.075
R-HSA-3247509 Chromatin modifying enzymes 8.443592e-01 0.073
R-HSA-202733 Cell surface interactions at the vascular wall 8.477685e-01 0.072
R-HSA-9824446 Viral Infection Pathways 8.478517e-01 0.072
R-HSA-5619115 Disorders of transmembrane transporters 8.586070e-01 0.066
R-HSA-382551 Transport of small molecules 8.594700e-01 0.066
R-HSA-4839726 Chromatin organization 8.606811e-01 0.065
R-HSA-388841 Regulation of T cell activation by CD28 family 8.677055e-01 0.062
R-HSA-73857 RNA Polymerase II Transcription 8.866045e-01 0.052
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 8.884045e-01 0.051
R-HSA-1280218 Adaptive Immune System 8.934594e-01 0.049
R-HSA-212436 Generic Transcription Pathway 8.946169e-01 0.048
R-HSA-1280215 Cytokine Signaling in Immune system 9.057942e-01 0.043
R-HSA-392499 Metabolism of proteins 9.131491e-01 0.039
R-HSA-112315 Transmission across Chemical Synapses 9.194655e-01 0.036
R-HSA-388396 GPCR downstream signalling 9.321055e-01 0.031
R-HSA-73894 DNA Repair 9.388286e-01 0.027
R-HSA-196854 Metabolism of vitamins and cofactors 9.406227e-01 0.027
R-HSA-71291 Metabolism of amino acids and derivatives 9.488818e-01 0.023
R-HSA-372790 Signaling by GPCR 9.570695e-01 0.019
R-HSA-74160 Gene expression (Transcription) 9.604826e-01 0.018
R-HSA-5668914 Diseases of metabolism 9.631604e-01 0.016
R-HSA-6798695 Neutrophil degranulation 9.705661e-01 0.013
R-HSA-5663205 Infectious disease 9.882896e-01 0.005
R-HSA-168249 Innate Immune System 9.904765e-01 0.004
R-HSA-168256 Immune System 9.997403e-01 0.000
R-HSA-9709957 Sensory Perception 9.999264e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.835 0.230 1 0.831
COTCOT 0.833 0.156 2 0.786
CDC7CDC7 0.823 0.125 1 0.852
GRK1GRK1 0.821 0.162 -2 0.783
NDR2NDR2 0.820 0.108 -3 0.815
RSK2RSK2 0.820 0.160 -3 0.779
PIM3PIM3 0.819 0.104 -3 0.831
MOSMOS 0.818 0.131 1 0.846
IKKBIKKB 0.818 0.016 -2 0.751
BMPR1BBMPR1B 0.818 0.314 1 0.839
SRPK1SRPK1 0.817 0.156 -3 0.771
FAM20CFAM20C 0.815 0.196 2 0.683
DSTYKDSTYK 0.815 0.061 2 0.825
CAMK2GCAMK2G 0.815 0.060 2 0.803
PRKD1PRKD1 0.814 0.128 -3 0.801
CAMK1BCAMK1B 0.814 0.105 -3 0.852
MTORMTOR 0.812 -0.026 1 0.775
PRPKPRPK 0.812 -0.035 -1 0.833
RAF1RAF1 0.812 -0.018 1 0.829
CAMK2BCAMK2B 0.812 0.167 2 0.805
PIM1PIM1 0.811 0.140 -3 0.790
GCN2GCN2 0.810 -0.074 2 0.760
CDKL1CDKL1 0.810 0.101 -3 0.809
P90RSKP90RSK 0.810 0.105 -3 0.780
GRK6GRK6 0.810 0.119 1 0.840
MST4MST4 0.810 0.093 2 0.787
NDR1NDR1 0.810 0.075 -3 0.816
PRKD2PRKD2 0.810 0.130 -3 0.766
GRK5GRK5 0.809 0.025 -3 0.831
SRPK2SRPK2 0.809 0.139 -3 0.702
KISKIS 0.809 0.068 1 0.695
RSK3RSK3 0.809 0.107 -3 0.776
CAMK2DCAMK2D 0.809 0.093 -3 0.817
CDKL5CDKL5 0.809 0.125 -3 0.796
TGFBR1TGFBR1 0.809 0.264 -2 0.878
MARK4MARK4 0.808 0.081 4 0.809
ERK5ERK5 0.808 0.067 1 0.833
CAMK2ACAMK2A 0.808 0.144 2 0.806
TGFBR2TGFBR2 0.808 0.111 -2 0.845
CLK2CLK2 0.808 0.181 -3 0.770
MAPKAPK2MAPKAPK2 0.807 0.130 -3 0.734
TBK1TBK1 0.807 -0.055 1 0.729
IKKAIKKA 0.807 0.032 -2 0.745
GRK7GRK7 0.807 0.166 1 0.776
SKMLCKSKMLCK 0.807 0.065 -2 0.795
ULK2ULK2 0.807 -0.080 2 0.712
BMPR2BMPR2 0.807 0.019 -2 0.881
RSK4RSK4 0.806 0.138 -3 0.751
LATS2LATS2 0.806 0.073 -5 0.674
PKN3PKN3 0.806 0.054 -3 0.817
HIPK4HIPK4 0.806 0.087 1 0.746
NEK6NEK6 0.806 0.012 -2 0.843
NLKNLK 0.806 0.004 1 0.808
AURCAURC 0.805 0.100 -2 0.620
AMPKA1AMPKA1 0.805 0.104 -3 0.831
PDHK4PDHK4 0.805 -0.169 1 0.817
NUAK2NUAK2 0.805 0.055 -3 0.839
ATRATR 0.805 -0.016 1 0.784
WNK1WNK1 0.804 0.036 -2 0.822
IKKEIKKE 0.804 -0.070 1 0.731
PKACGPKACG 0.804 0.091 -2 0.724
SRPK3SRPK3 0.804 0.121 -3 0.749
P70S6KBP70S6KB 0.803 0.097 -3 0.794
ICKICK 0.803 0.093 -3 0.834
CHAK2CHAK2 0.803 0.050 -1 0.857
HUNKHUNK 0.803 -0.025 2 0.767
ALK4ALK4 0.803 0.216 -2 0.896
PRKXPRKX 0.802 0.163 -3 0.695
TSSK2TSSK2 0.802 0.108 -5 0.784
NIKNIK 0.802 0.014 -3 0.855
ALK2ALK2 0.802 0.270 -2 0.872
TSSK1TSSK1 0.801 0.126 -3 0.843
GRK4GRK4 0.801 -0.019 -2 0.819
BMPR1ABMPR1A 0.801 0.278 1 0.825
NEK7NEK7 0.801 -0.080 -3 0.815
PKACBPKACB 0.800 0.116 -2 0.636
CAMLCKCAMLCK 0.800 0.021 -2 0.803
AMPKA2AMPKA2 0.800 0.094 -3 0.804
PKN2PKN2 0.799 0.037 -3 0.823
PKCDPKCD 0.799 0.046 2 0.698
MAPKAPK3MAPKAPK3 0.799 0.061 -3 0.765
BCKDKBCKDK 0.799 -0.072 -1 0.807
PDHK1PDHK1 0.798 -0.165 1 0.812
DAPK2DAPK2 0.798 0.018 -3 0.850
ACVR2BACVR2B 0.797 0.189 -2 0.855
ACVR2AACVR2A 0.797 0.176 -2 0.852
MLK1MLK1 0.797 -0.102 2 0.731
LATS1LATS1 0.796 0.119 -3 0.822
ULK1ULK1 0.796 -0.127 -3 0.779
CLK4CLK4 0.796 0.093 -3 0.781
ATMATM 0.795 0.013 1 0.735
QSKQSK 0.795 0.067 4 0.788
NIM1NIM1 0.795 0.003 3 0.603
CK2A2CK2A2 0.794 0.208 1 0.708
BRSK1BRSK1 0.794 0.050 -3 0.788
MSK2MSK2 0.794 0.028 -3 0.753
PAK1PAK1 0.793 0.015 -2 0.717
MARK3MARK3 0.793 0.077 4 0.756
PLK1PLK1 0.793 0.033 -2 0.793
PRKD3PRKD3 0.793 0.087 -3 0.758
MSK1MSK1 0.793 0.063 -3 0.753
MNK2MNK2 0.792 0.042 -2 0.732
CLK1CLK1 0.792 0.101 -3 0.761
CDK1CDK1 0.792 0.049 1 0.638
JNK2JNK2 0.792 0.091 1 0.628
MASTLMASTL 0.792 -0.184 -2 0.791
CDK8CDK8 0.792 0.017 1 0.660
AKT2AKT2 0.792 0.107 -3 0.716
DLKDLK 0.791 -0.116 1 0.813
PAK6PAK6 0.791 0.069 -2 0.641
RIPK3RIPK3 0.791 -0.145 3 0.557
TTBK2TTBK2 0.791 -0.090 2 0.657
SGK3SGK3 0.791 0.112 -3 0.763
SIKSIK 0.791 0.054 -3 0.761
PLK3PLK3 0.791 0.038 2 0.740
CDK5CDK5 0.790 0.064 1 0.685
PKCBPKCB 0.790 0.030 2 0.644
JNK3JNK3 0.790 0.069 1 0.657
NEK9NEK9 0.789 -0.122 2 0.765
PKCGPKCG 0.789 0.011 2 0.644
DYRK2DYRK2 0.789 0.045 1 0.686
DNAPKDNAPK 0.789 0.044 1 0.686
PKRPKR 0.788 0.025 1 0.792
PKG2PKG2 0.788 0.078 -2 0.662
QIKQIK 0.788 -0.022 -3 0.816
AURBAURB 0.787 0.030 -2 0.611
DCAMKL1DCAMKL1 0.787 0.105 -3 0.784
MARK2MARK2 0.787 0.047 4 0.719
WNK3WNK3 0.787 -0.209 1 0.774
MLK3MLK3 0.787 -0.075 2 0.662
ANKRD3ANKRD3 0.787 -0.134 1 0.828
MLK2MLK2 0.787 -0.109 2 0.744
GRK2GRK2 0.786 0.019 -2 0.746
P38AP38A 0.786 0.061 1 0.718
PAK3PAK3 0.786 -0.037 -2 0.716
HIPK2HIPK2 0.786 0.088 1 0.598
PKCAPKCA 0.786 0.005 2 0.641
MNK1MNK1 0.786 0.029 -2 0.750
PIM2PIM2 0.786 0.088 -3 0.757
CDK19CDK19 0.786 0.017 1 0.625
MELKMELK 0.785 0.015 -3 0.788
TLK2TLK2 0.785 0.027 1 0.747
P38BP38B 0.785 0.074 1 0.663
IRE1IRE1 0.785 -0.089 1 0.739
CDK13CDK13 0.785 0.016 1 0.643
CDK7CDK7 0.785 0.014 1 0.669
CDK18CDK18 0.785 0.053 1 0.605
BRSK2BRSK2 0.784 -0.011 -3 0.797
AURAAURA 0.784 0.002 -2 0.568
CAMK4CAMK4 0.784 -0.053 -3 0.805
HIPK1HIPK1 0.784 0.084 1 0.696
CK2A1CK2A1 0.784 0.174 1 0.687
MEK1MEK1 0.784 -0.101 2 0.779
PHKG1PHKG1 0.783 -0.016 -3 0.809
BRAFBRAF 0.783 0.017 -4 0.747
PKACAPKACA 0.783 0.090 -2 0.603
MARK1MARK1 0.783 0.024 4 0.769
P38GP38G 0.783 0.060 1 0.561
MYLK4MYLK4 0.783 0.005 -2 0.711
ERK1ERK1 0.783 0.044 1 0.645
MLK4MLK4 0.782 -0.080 2 0.647
NUAK1NUAK1 0.782 -0.022 -3 0.785
DRAK1DRAK1 0.782 -0.022 1 0.780
NEK2NEK2 0.782 -0.064 2 0.729
CDK3CDK3 0.782 0.048 1 0.580
YSK4YSK4 0.781 -0.110 1 0.762
PKCHPKCH 0.781 -0.019 2 0.633
RIPK1RIPK1 0.781 -0.203 1 0.769
SSTKSSTK 0.781 0.095 4 0.770
CK1ECK1E 0.780 0.012 -3 0.581
CHK1CHK1 0.780 0.010 -3 0.788
PLK4PLK4 0.780 -0.053 2 0.577
PKCZPKCZ 0.780 -0.041 2 0.686
CDK12CDK12 0.779 0.022 1 0.622
GRK3GRK3 0.779 0.036 -2 0.707
PASKPASK 0.779 0.051 -3 0.844
CHAK1CHAK1 0.778 -0.108 2 0.689
VRK2VRK2 0.778 -0.178 1 0.824
CAMK1GCAMK1G 0.778 0.017 -3 0.771
PAK2PAK2 0.778 -0.070 -2 0.704
SMG1SMG1 0.777 -0.074 1 0.723
PERKPERK 0.777 -0.045 -2 0.858
MST3MST3 0.777 0.026 2 0.751
CDK9CDK9 0.777 -0.001 1 0.654
IRE2IRE2 0.776 -0.099 2 0.636
AKT1AKT1 0.776 0.066 -3 0.724
DCAMKL2DCAMKL2 0.776 0.040 -3 0.804
MEKK3MEKK3 0.775 -0.119 1 0.787
CDK2CDK2 0.775 -0.042 1 0.715
CDK17CDK17 0.775 0.019 1 0.562
DYRK1ADYRK1A 0.774 0.043 1 0.721
P70S6KP70S6K 0.774 0.048 -3 0.716
DYRK4DYRK4 0.774 0.047 1 0.622
TAO3TAO3 0.773 -0.024 1 0.779
MAKMAK 0.773 0.148 -2 0.701
PRP4PRP4 0.773 -0.014 -3 0.714
CAMK1DCAMK1D 0.773 0.072 -3 0.702
CK1G1CK1G1 0.773 -0.013 -3 0.578
MEKK2MEKK2 0.773 -0.076 2 0.729
MAPKAPK5MAPKAPK5 0.772 -0.063 -3 0.726
ERK2ERK2 0.772 -0.012 1 0.668
HIPK3HIPK3 0.772 0.031 1 0.700
TLK1TLK1 0.772 -0.022 -2 0.847
SGK1SGK1 0.771 0.112 -3 0.642
ZAKZAK 0.771 -0.125 1 0.771
CDK10CDK10 0.771 0.065 1 0.630
MEK5MEK5 0.771 -0.199 2 0.752
CK1DCK1D 0.770 0.006 -3 0.533
NEK5NEK5 0.770 -0.081 1 0.785
AKT3AKT3 0.770 0.091 -3 0.660
MEKK1MEKK1 0.770 -0.136 1 0.777
P38DP38D 0.770 0.048 1 0.565
GSK3AGSK3A 0.770 0.007 4 0.403
PKCTPKCT 0.770 -0.015 2 0.641
HRIHRI 0.769 -0.129 -2 0.865
WNK4WNK4 0.769 -0.090 -2 0.814
CK1A2CK1A2 0.769 0.007 -3 0.537
PHKG2PHKG2 0.769 -0.023 -3 0.790
JNK1JNK1 0.769 0.042 1 0.613
DYRK1BDYRK1B 0.769 0.031 1 0.647
EEF2KEEF2K 0.768 0.040 3 0.688
SNRKSNRK 0.768 -0.167 2 0.602
PINK1PINK1 0.768 -0.157 1 0.763
SMMLCKSMMLCK 0.768 -0.025 -3 0.813
PKCEPKCE 0.768 0.036 2 0.631
PAK5PAK5 0.768 -0.007 -2 0.579
CDK16CDK16 0.768 0.041 1 0.570
CDK14CDK14 0.768 0.020 1 0.645
PLK2PLK2 0.767 0.036 -3 0.781
MPSK1MPSK1 0.767 0.021 1 0.719
PAK4PAK4 0.767 0.004 -2 0.580
DYRK3DYRK3 0.766 0.027 1 0.695
PKCIPKCI 0.766 -0.022 2 0.649
PDK1PDK1 0.765 -0.017 1 0.783
IRAK4IRAK4 0.765 -0.108 1 0.749
DAPK3DAPK3 0.765 0.033 -3 0.802
GSK3BGSK3B 0.765 -0.037 4 0.392
TNIKTNIK 0.764 0.043 3 0.691
GAKGAK 0.764 0.008 1 0.800
TAO2TAO2 0.763 -0.063 2 0.764
TTBK1TTBK1 0.763 -0.149 2 0.576
MRCKBMRCKB 0.763 0.081 -3 0.742
GCKGCK 0.762 -0.024 1 0.793
CAMKK2CAMKK2 0.762 -0.086 -2 0.726
LKB1LKB1 0.762 -0.062 -3 0.787
CAMKK1CAMKK1 0.761 -0.131 -2 0.717
NEK8NEK8 0.761 -0.156 2 0.725
MOKMOK 0.760 0.104 1 0.715
ROCK2ROCK2 0.760 0.088 -3 0.779
ERK7ERK7 0.760 -0.011 2 0.464
DAPK1DAPK1 0.759 0.017 -3 0.789
MINKMINK 0.759 -0.022 1 0.778
HGKHGK 0.759 -0.021 3 0.676
SBKSBK 0.759 0.083 -3 0.611
HPK1HPK1 0.759 -0.005 1 0.784
MST2MST2 0.758 -0.074 1 0.798
NEK11NEK11 0.758 -0.174 1 0.787
PKN1PKN1 0.758 0.013 -3 0.735
MAP3K15MAP3K15 0.757 -0.070 1 0.756
CAMK1ACAMK1A 0.757 0.052 -3 0.682
CHK2CHK2 0.757 0.036 -3 0.668
CDK6CDK6 0.756 0.015 1 0.623
KHS2KHS2 0.756 0.042 1 0.782
LRRK2LRRK2 0.755 -0.095 2 0.767
BUB1BUB1 0.755 0.065 -5 0.731
KHS1KHS1 0.755 0.019 1 0.770
TAK1TAK1 0.755 -0.094 1 0.798
LOKLOK 0.755 -0.035 -2 0.765
CDK4CDK4 0.754 0.021 1 0.603
MRCKAMRCKA 0.754 0.031 -3 0.754
NEK4NEK4 0.754 -0.134 1 0.757
MEKK6MEKK6 0.753 -0.088 1 0.779
PBKPBK 0.753 0.019 1 0.731
DMPK1DMPK1 0.752 0.089 -3 0.774
NEK1NEK1 0.752 -0.075 1 0.762
STK33STK33 0.752 -0.124 2 0.573
IRAK1IRAK1 0.751 -0.260 -1 0.746
SLKSLK 0.750 -0.082 -2 0.732
MST1MST1 0.749 -0.103 1 0.779
CRIKCRIK 0.749 0.104 -3 0.722
PDHK3_TYRPDHK3_TYR 0.748 0.209 4 0.840
YSK1YSK1 0.747 -0.062 2 0.732
PKG1PKG1 0.747 0.030 -2 0.596
MEK2MEK2 0.745 -0.176 2 0.745
HASPINHASPIN 0.744 0.051 -1 0.771
ROCK1ROCK1 0.744 0.050 -3 0.751
VRK1VRK1 0.743 -0.186 2 0.730
YANK3YANK3 0.742 -0.050 2 0.381
OSR1OSR1 0.742 -0.055 2 0.727
TTKTTK 0.741 -0.014 -2 0.814
CK1ACK1A 0.741 -0.016 -3 0.453
MAP2K4_TYRMAP2K4_TYR 0.739 0.069 -1 0.859
NEK3NEK3 0.739 -0.110 1 0.734
MAP2K6_TYRMAP2K6_TYR 0.738 0.060 -1 0.861
TESK1_TYRTESK1_TYR 0.736 -0.023 3 0.700
PDHK4_TYRPDHK4_TYR 0.736 0.017 2 0.813
BIKEBIKE 0.735 0.008 1 0.675
BMPR2_TYRBMPR2_TYR 0.735 0.029 -1 0.859
MAP2K7_TYRMAP2K7_TYR 0.734 -0.081 2 0.801
EPHA6EPHA6 0.733 0.096 -1 0.828
ASK1ASK1 0.733 -0.116 1 0.743
RIPK2RIPK2 0.733 -0.302 1 0.733
PDHK1_TYRPDHK1_TYR 0.733 -0.026 -1 0.860
PKMYT1_TYRPKMYT1_TYR 0.731 -0.070 3 0.666
MYO3BMYO3B 0.731 -0.080 2 0.731
TAO1TAO1 0.730 -0.102 1 0.710
LIMK2_TYRLIMK2_TYR 0.729 0.016 -3 0.844
ALPHAK3ALPHAK3 0.729 -0.066 -1 0.756
PINK1_TYRPINK1_TYR 0.729 -0.129 1 0.798
MYO3AMYO3A 0.727 -0.115 1 0.745
EPHB4EPHB4 0.727 0.021 -1 0.810
AAK1AAK1 0.722 0.049 1 0.580
RETRET 0.722 -0.129 1 0.777
EPHA4EPHA4 0.721 0.008 2 0.742
LIMK1_TYRLIMK1_TYR 0.721 -0.148 2 0.779
TXKTXK 0.720 0.048 1 0.829
TYK2TYK2 0.720 -0.172 1 0.778
MST1RMST1R 0.719 -0.167 3 0.620
ABL2ABL2 0.718 -0.031 -1 0.754
DDR1DDR1 0.718 -0.113 4 0.764
ROS1ROS1 0.718 -0.134 3 0.575
STLK3STLK3 0.717 -0.183 1 0.731
JAK2JAK2 0.717 -0.162 1 0.781
FERFER 0.717 -0.081 1 0.857
SRMSSRMS 0.717 -0.028 1 0.852
TYRO3TYRO3 0.716 -0.163 3 0.594
EPHB2EPHB2 0.716 0.003 -1 0.785
EPHB1EPHB1 0.716 -0.042 1 0.861
INSRRINSRR 0.716 -0.086 3 0.551
CK1G3CK1G3 0.715 -0.034 -3 0.413
TNK2TNK2 0.715 -0.056 3 0.566
CSF1RCSF1R 0.714 -0.152 3 0.585
YES1YES1 0.714 -0.087 -1 0.774
EPHB3EPHB3 0.714 -0.035 -1 0.787
FGRFGR 0.713 -0.113 1 0.823
JAK3JAK3 0.713 -0.123 1 0.762
ABL1ABL1 0.713 -0.063 -1 0.742
BLKBLK 0.712 0.016 -1 0.767
LCKLCK 0.712 -0.025 -1 0.760
ITKITK 0.711 -0.069 -1 0.745
HCKHCK 0.711 -0.090 -1 0.760
FGFR2FGFR2 0.711 -0.131 3 0.595
YANK2YANK2 0.711 -0.070 2 0.402
TNNI3K_TYRTNNI3K_TYR 0.710 -0.050 1 0.779
EPHA7EPHA7 0.709 -0.031 2 0.734
BMXBMX 0.708 -0.044 -1 0.670
MERTKMERTK 0.708 -0.093 3 0.572
TNK1TNK1 0.707 -0.101 3 0.582
NEK10_TYRNEK10_TYR 0.707 -0.112 1 0.650
KITKIT 0.707 -0.159 3 0.584
PDGFRBPDGFRB 0.707 -0.203 3 0.597
FLT3FLT3 0.707 -0.175 3 0.589
EPHA3EPHA3 0.707 -0.090 2 0.714
KDRKDR 0.706 -0.149 3 0.548
FYNFYN 0.706 -0.019 -1 0.736
TECTEC 0.705 -0.085 -1 0.678
METMET 0.704 -0.131 3 0.580
FLT1FLT1 0.704 -0.108 -1 0.813
JAK1JAK1 0.704 -0.131 1 0.735
LTKLTK 0.703 -0.126 3 0.545
AXLAXL 0.703 -0.160 3 0.572
EPHA5EPHA5 0.703 -0.025 2 0.730
FGFR1FGFR1 0.703 -0.189 3 0.570
CK1G2CK1G2 0.703 -0.023 -3 0.500
PTK2PTK2 0.702 0.027 -1 0.774
TEKTEK 0.701 -0.198 3 0.530
NTRK1NTRK1 0.701 -0.187 -1 0.786
ERBB2ERBB2 0.701 -0.165 1 0.751
BTKBTK 0.700 -0.182 -1 0.706
FGFR3FGFR3 0.700 -0.150 3 0.569
ALKALK 0.700 -0.172 3 0.521
WEE1_TYRWEE1_TYR 0.700 -0.151 -1 0.731
FRKFRK 0.700 -0.106 -1 0.773
SYKSYK 0.700 0.026 -1 0.746
EGFREGFR 0.699 -0.059 1 0.667
EPHA1EPHA1 0.699 -0.120 3 0.569
EPHA8EPHA8 0.699 -0.061 -1 0.763
DDR2DDR2 0.699 -0.055 3 0.540
LYNLYN 0.698 -0.112 3 0.530
INSRINSR 0.698 -0.157 3 0.549
PTK2BPTK2B 0.698 -0.080 -1 0.706
NTRK3NTRK3 0.696 -0.144 -1 0.734
PDGFRAPDGFRA 0.695 -0.299 3 0.589
PTK6PTK6 0.695 -0.227 -1 0.672
FGFR4FGFR4 0.694 -0.103 -1 0.733
CSKCSK 0.693 -0.148 2 0.735
MATKMATK 0.693 -0.134 -1 0.695
SRCSRC 0.693 -0.108 -1 0.725
FLT4FLT4 0.693 -0.221 3 0.550
NTRK2NTRK2 0.692 -0.252 3 0.541
EPHA2EPHA2 0.690 -0.063 -1 0.744
IGF1RIGF1R 0.686 -0.138 3 0.487
ERBB4ERBB4 0.685 -0.066 1 0.690
MUSKMUSK 0.676 -0.181 1 0.658
ZAP70ZAP70 0.671 -0.058 -1 0.674
FESFES 0.669 -0.164 -1 0.641