Motif 937 (n=139)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S381 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O14744 | PRMT5 | S310 | ochoa | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
| O14920 | IKBKB | S692 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O43847 | NRDC | S106 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60343 | TBC1D4 | S551 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O75369 | FLNB | S658 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O95475 | SIX6 | S227 | ochoa | Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) | May be involved in eye development. |
| O95865 | DDAH2 | S245 | psp | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}. |
| O95886 | DLGAP3 | S932 | ochoa | Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| O95983 | MBD3 | S37 | ochoa | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| P00740 | F9 | S114 | ochoa | Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain] | Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. {ECO:0000269|PubMed:1730085, ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:8295821}. |
| P06239 | LCK | S102 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P08195 | SLC3A2 | S607 | ochoa | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P08514 | ITGA2B | S432 | ochoa | Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:9111081}. |
| P08567 | PLEK | S113 | psp | Pleckstrin (Platelet 47 kDa protein) (p47) | Major protein kinase C substrate of platelets. |
| P12814 | ACTN1 | S428 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P18206 | VCL | S443 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20700 | LMNB1 | S23 | ochoa|psp | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P22090 | RPS4Y1 | S32 | ochoa | Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) | None |
| P29274 | ADORA2A | S374 | psp | Adenosine receptor A2a | Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| P30530 | AXL | S612 | ochoa | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| P31327 | CPS1 | S1079 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31930 | UQCRC1 | S107 | ochoa | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179). {ECO:0000250|UniProtKB:P07256, ECO:0000250|UniProtKB:P31800, ECO:0000269|PubMed:33141179, ECO:0000305|PubMed:29243944}. |
| P38646 | HSPA9 | S212 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P45973 | CBX5 | S132 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P47712 | PLA2G4A | S505 | psp | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P47900 | P2RY1 | S346 | ochoa | P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) | Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). {ECO:0000269|PubMed:25822790, ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}. |
| P49327 | FASN | S724 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S380 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49796 | RGS3 | S1007 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P50336 | PPOX | S213 | ochoa | Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) | Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. {ECO:0000269|PubMed:21048046, ECO:0000269|PubMed:23467411, ECO:0000269|PubMed:7713909}. |
| P51798 | CLCN7 | S48 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P55017 | SLC12A3 | S73 | psp | Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) | Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). {ECO:0000250|UniProtKB:P59158, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22009145, ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}. |
| P62701 | RPS4X | S32 | ochoa | Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P83916 | CBX1 | S128 | ochoa | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
| Q00653 | NFKB2 | S812 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q03252 | LMNB2 | S37 | ochoa|psp | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q05639 | EEF1A2 | S358 | psp | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q07912 | TNK2 | S856 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q08378 | GOLGA3 | S115 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q08AM6 | VAC14 | S517 | ochoa | Protein VAC14 homolog (Tax1-binding protein 2) | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}. |
| Q12905 | ILF2 | S68 | ochoa | Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) | Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12955 | ANK3 | S531 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13011 | ECH1 | S139 | ochoa | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) | Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}. |
| Q13017 | ARHGAP5 | S590 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13136 | PPFIA1 | S838 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13185 | CBX3 | S132 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13459 | MYO9B | S1329 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q14004 | CDK13 | S1229 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14684 | RRP1B | S160 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q15036 | SNX17 | S312 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15772 | SPEG | S2448 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16647 | PTGIS | S221 | ochoa | Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323). {ECO:0000269|PubMed:12372404, ECO:0000269|PubMed:15115769, ECO:0000269|PubMed:17459323, ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}. |
| Q53LP3 | SOWAHC | S408 | ochoa | Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) | None |
| Q53T59 | HS1BP3 | S289 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5SSJ5 | HP1BP3 | S176 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T447 | HECTD3 | S95 | psp | E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) | E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}. |
| Q5VTQ0 | TTC39B | S127 | ochoa | Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) | Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). {ECO:0000250|UniProtKB:Q8BYY4}. |
| Q5VZK9 | CARMIL1 | S294 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q69YU3 | ANKRD34A | S461 | ochoa | Ankyrin repeat domain-containing protein 34A | None |
| Q6BDS2 | BLTP3A | S944 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6MZZ7 | CAPN13 | S501 | ochoa | Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13) | Probable non-lysosomal thiol-protease. {ECO:0000250}. |
| Q6P5Z2 | PKN3 | S866 | ochoa | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Q6ZMQ8 | AATK | S946 | ochoa | Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) | May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}. |
| Q6ZSZ6 | TSHZ1 | S919 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q6ZV73 | FGD6 | S70 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7L014 | DDX46 | S892 | ochoa | Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}. |
| Q7Z2W4 | ZC3HAV1 | S101 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3J3 | RGPD4 | S381 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z7A1 | CNTRL | S831 | ochoa | Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) | Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}. |
| Q86V48 | LUZP1 | S839 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VY9 | TMEM200A | S384 | ochoa | Transmembrane protein 200A | None |
| Q86XK3 | SFR1 | S35 | ochoa | Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) | Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}. |
| Q86XL3 | ANKLE2 | S53 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YW5 | TREML1 | S211 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IWT3 | CUL9 | S947 | ochoa | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (PubMed:38605244). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (PubMed:12526791, PubMed:17332328). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (PubMed:38605244). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (PubMed:38605244). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:38605244}. |
| Q8IWU2 | LMTK2 | S525 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8N556 | AFAP1 | S495 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8N5I9 | NOPCHAP1 | S56 | ochoa | NOP protein chaperone 1 | Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. {ECO:0000269|PubMed:33367824}. |
| Q8NDX1 | PSD4 | S921 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8TE67 | EPS8L3 | S518 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
| Q8WUY9 | DEPDC1B | S436 | ochoa | DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) | None |
| Q92552 | MRPS27 | S301 | ochoa | Small ribosomal subunit protein mS27 (28S ribosomal protein S27, mitochondrial) (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27) | RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366). {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:28714366}. |
| Q92622 | RUBCN | S946 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q92734 | TFG | S99 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q92966 | SNAPC3 | S74 | ochoa | snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}. |
| Q92994 | BRF1 | S392 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q969G5 | CAVIN3 | S62 | ochoa | Caveolae-associated protein 3 (Cavin-3) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC) | Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). {ECO:0000250|UniProtKB:Q91VJ2, ECO:0000250|UniProtKB:Q9Z1H9, ECO:0000269|PubMed:19262564}. |
| Q96DF8 | ESS2 | S446 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96H22 | CENPN | S320 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96MH2 | HEXIM2 | S29 | ochoa|psp | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
| Q96MX3 | ZNF48 | S316 | ochoa | Zinc finger protein 48 (Zinc finger protein 553) | May be involved in transcriptional regulation. |
| Q96T37 | RBM15 | S872 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99459 | CDC5L | S460 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99626 | CDX2 | S176 | ochoa | Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) | Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}. |
| Q99832 | CCT7 | S59 | psp | T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q99959 | PKP2 | S312 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BV19 | C1orf50 | S43 | ochoa | Uncharacterized protein C1orf50 | None |
| Q9BV73 | CEP250 | S2259 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BXL7 | CARD11 | S879 | ochoa | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BYT8 | NLN | S32 | ochoa | Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase) | Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P42676}. |
| Q9BYW2 | SETD2 | S1144 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C073 | FAM117A | S201 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9H4L5 | OSBPL3 | S372 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H6A9 | PCNX3 | S1955 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9HC07 | TMEM165 | S221 | ochoa | Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL) | Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity) (PubMed:22683087, PubMed:23569283, PubMed:27008884, PubMed:32047108). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated. {ECO:0000250|UniProtKB:P38301, ECO:0000250|UniProtKB:P52875, ECO:0000269|PubMed:22683087, ECO:0000269|PubMed:23569283, ECO:0000269|PubMed:27008884, ECO:0000269|PubMed:32047108}. |
| Q9NP71 | MLXIPL | S361 | ochoa | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000250|UniProtKB:Q9HAP2}. |
| Q9NQC3 | RTN4 | S239 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQV8 | PRDM8 | S375 | ochoa | PR domain zinc finger protein 8 (EC 2.1.1.-) (PR domain-containing protein 8) | Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity). {ECO:0000250|UniProtKB:Q8BZ97}. |
| Q9NR16 | CD163L1 | S1426 | ochoa | Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) (CD antigen CD163b) | None |
| Q9NRM7 | LATS2 | S342 | ochoa | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NYL2 | MAP3K20 | S362 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NYL9 | TMOD3 | S57 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9P260 | RELCH | S93 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9UDY4 | DNAJB4 | S148 | ochoa | DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) | Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| Q9UHY8 | FEZ2 | S205 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UJZ1 | STOML2 | S330 | ochoa | Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7) | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}. |
| Q9UK58 | CCNL1 | S69 | ochoa | Cyclin-L1 (Cyclin-L) | Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}. |
| Q9UMZ2 | SYNRG | S1085 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPV0 | CEP164 | S1054 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPX0 | IGSF9B | S1202 | ochoa | Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B) | Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion. {ECO:0000250|UniProtKB:D3ZB51, ECO:0000250|UniProtKB:E9PZ19}. |
| Q9Y467 | SALL2 | S874 | ochoa | Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) | Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. {ECO:0000269|PubMed:24412933}. |
| Q9Y4F5 | CEP170B | S337 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4K1 | CRYBG1 | S72 | ochoa | Beta/gamma crystallin domain-containing protein 1 (Absent in melanoma 1 protein) | May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. |
| Q9Y5S2 | CDC42BPB | S1029 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y6Y8 | SEC23IP | S524 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| Q16881 | TXNRD1 | S329 | Sugiyama | Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) | Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). {ECO:0000269|PubMed:10849437, ECO:0000269|PubMed:8577704, ECO:0000305|PubMed:17512005}.; FUNCTION: [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. {ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8577704}.; FUNCTION: [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. {ECO:0000269|PubMed:15199063}.; FUNCTION: [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665). {ECO:0000269|PubMed:15199063, ECO:0000269|PubMed:9774665}. |
| P04843 | RPN1 | S385 | Sugiyama | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39567208}. |
| P60228 | EIF3E | S203 | Sugiyama | Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P30153 | PPP2R1A | S146 | Sugiyama | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed:33243860, PubMed:33633399, PubMed:34004147, PubMed:8694763). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:18782753, PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753, PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). {ECO:0000250|UniProtKB:Q76MZ3, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:8694763}. |
| P21802 | FGFR2 | S587 | Sugiyama | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
| P29322 | EPHA8 | S752 | Sugiyama | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| O43707 | ACTN4 | S447 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P56645 | PER3 | S634 | SIGNOR|iPTMNet | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
| P52333 | JAK3 | S1031 | Sugiyama | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}. |
| P17987 | TCP1 | S372 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q16513 | PKN2 | S183 | Sugiyama | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q9H093 | NUAK2 | S331 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q9H1R3 | MYLK2 | S158 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.000005 | 5.303 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.000005 | 5.267 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.000021 | 4.678 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.000029 | 4.540 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.000063 | 4.199 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.000126 | 3.900 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.000101 | 3.994 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 0.000146 | 3.835 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.000215 | 3.667 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.000284 | 3.546 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000324 | 3.489 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000398 | 3.401 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.000360 | 3.444 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.000402 | 3.396 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.000435 | 3.361 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.000880 | 3.055 |
| R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 0.001187 | 2.926 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 0.001651 | 2.782 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.001986 | 2.702 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.002195 | 2.659 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.002595 | 2.586 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.002641 | 2.578 |
| R-HSA-109704 | PI3K Cascade | 0.002834 | 2.548 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.002980 | 2.526 |
| R-HSA-72649 | Translation initiation complex formation | 0.003589 | 2.445 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.003481 | 2.458 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.004596 | 2.338 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.004013 | 2.396 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.004036 | 2.394 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.004470 | 2.350 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.003985 | 2.400 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.004600 | 2.337 |
| R-HSA-112399 | IRS-mediated signalling | 0.004238 | 2.373 |
| R-HSA-190236 | Signaling by FGFR | 0.004908 | 2.309 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.005764 | 2.239 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.005764 | 2.239 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005525 | 2.258 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.005220 | 2.282 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.006050 | 2.218 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.006050 | 2.218 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.006344 | 2.198 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.006649 | 2.177 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.007618 | 2.118 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.008778 | 2.057 |
| R-HSA-190377 | FGFR2b ligand binding and activation | 0.008778 | 2.057 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.008216 | 2.085 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.008769 | 2.057 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.009052 | 2.043 |
| R-HSA-380287 | Centrosome maturation | 0.009829 | 2.007 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.009574 | 2.019 |
| R-HSA-9673218 | Defective F9 secretion | 0.009887 | 2.005 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.010677 | 1.972 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.011195 | 1.951 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.011592 | 1.936 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 0.012694 | 1.896 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.012694 | 1.896 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.013863 | 1.858 |
| R-HSA-114608 | Platelet degranulation | 0.014229 | 1.847 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.013999 | 1.854 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.015653 | 1.805 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.016499 | 1.783 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.017141 | 1.766 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.017635 | 1.754 |
| R-HSA-202424 | Downstream TCR signaling | 0.017635 | 1.754 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.018877 | 1.724 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.019429 | 1.712 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.019429 | 1.712 |
| R-HSA-68877 | Mitotic Prometaphase | 0.019918 | 1.701 |
| R-HSA-68886 | M Phase | 0.019998 | 1.699 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.021990 | 1.658 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.021528 | 1.667 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.022355 | 1.651 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.022355 | 1.651 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.022355 | 1.651 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.022662 | 1.645 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.024455 | 1.612 |
| R-HSA-8853333 | Signaling by FGFR2 fusions | 0.029371 | 1.532 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.029371 | 1.532 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.029371 | 1.532 |
| R-HSA-5619087 | Defective SLC12A3 causes Gitelman syndrome (GS) | 0.029371 | 1.532 |
| R-HSA-9672396 | Defective cofactor function of FVIIIa variant | 0.038969 | 1.409 |
| R-HSA-9672383 | Defective factor IX causes thrombophilia | 0.038969 | 1.409 |
| R-HSA-9673202 | Defective F9 variant does not activate FX | 0.038969 | 1.409 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.048474 | 1.314 |
| R-HSA-9673240 | Defective gamma-carboxylation of F9 | 0.048474 | 1.314 |
| R-HSA-9673221 | Defective F9 activation | 0.067203 | 1.173 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.076429 | 1.117 |
| R-HSA-5263617 | Metabolism of ingested MeSeO2H into MeSeH | 0.085565 | 1.068 |
| R-HSA-111995 | phospho-PLA2 pathway | 0.103569 | 0.985 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.026075 | 1.584 |
| R-HSA-9668250 | Defective factor IX causes hemophilia B | 0.121220 | 0.916 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.129916 | 0.886 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.129916 | 0.886 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.129916 | 0.886 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.036366 | 1.439 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.138526 | 0.858 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.138526 | 0.858 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.147051 | 0.833 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.172128 | 0.764 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.172128 | 0.764 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.060667 | 1.217 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.180322 | 0.744 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.196471 | 0.707 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.036927 | 1.433 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.031693 | 1.499 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.032528 | 1.488 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.035997 | 1.444 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.035997 | 1.444 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.068032 | 1.167 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.068032 | 1.167 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.078554 | 1.105 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.080373 | 1.095 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.087831 | 1.056 |
| R-HSA-192823 | Viral mRNA Translation | 0.105619 | 0.976 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.155493 | 0.808 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.052905 | 1.277 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.147051 | 0.833 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.076429 | 1.117 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.112438 | 0.949 |
| R-HSA-156902 | Peptide chain elongation | 0.073208 | 1.135 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.098135 | 1.008 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.050403 | 1.298 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.036366 | 1.439 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.147051 | 0.833 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.080136 | 1.096 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.080136 | 1.096 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.063336 | 1.198 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.036366 | 1.439 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.104367 | 0.981 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.068790 | 1.162 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.218620 | 0.660 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.071574 | 1.145 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.083058 | 1.081 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.086013 | 1.065 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.068790 | 1.162 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.172128 | 0.764 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.103569 | 0.985 |
| R-HSA-9865881 | Complex III assembly | 0.036366 | 1.439 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.089740 | 1.047 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.107522 | 0.969 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.086013 | 1.065 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.101237 | 0.995 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.101237 | 0.995 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.101237 | 0.995 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.099540 | 1.002 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.086013 | 1.065 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.041587 | 1.381 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.180322 | 0.744 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.066346 | 1.178 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.041587 | 1.381 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.182058 | 0.740 |
| R-HSA-202403 | TCR signaling | 0.034236 | 1.466 |
| R-HSA-417973 | Adenosine P1 receptors | 0.048474 | 1.314 |
| R-HSA-187024 | NGF-independant TRKA activation | 0.076429 | 1.117 |
| R-HSA-389397 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | 0.076429 | 1.117 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.094612 | 1.024 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.103569 | 0.985 |
| R-HSA-176974 | Unwinding of DNA | 0.112438 | 0.949 |
| R-HSA-4839744 | Signaling by APC mutants | 0.129916 | 0.886 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.034200 | 1.466 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.138526 | 0.858 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.138526 | 0.858 |
| R-HSA-202670 | ERKs are inactivated | 0.138526 | 0.858 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.138526 | 0.858 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.155493 | 0.808 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.204427 | 0.689 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.120391 | 0.919 |
| R-HSA-191859 | snRNP Assembly | 0.143740 | 0.842 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.143740 | 0.842 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.069851 | 1.156 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.101237 | 0.995 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.182058 | 0.740 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.196471 | 0.707 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.204427 | 0.689 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.185617 | 0.731 |
| R-HSA-72766 | Translation | 0.081327 | 1.090 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.043485 | 1.362 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.192763 | 0.715 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.136972 | 0.863 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.112438 | 0.949 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.163851 | 0.786 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.108957 | 0.963 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.029371 | 1.532 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.138526 | 0.858 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.163851 | 0.786 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.172128 | 0.764 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 0.188437 | 0.725 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.204427 | 0.689 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.212304 | 0.673 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.227826 | 0.642 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.032528 | 1.488 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.226395 | 0.645 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.151862 | 0.819 |
| R-HSA-163685 | Integration of energy metabolism | 0.067299 | 1.172 |
| R-HSA-2028269 | Signaling by Hippo | 0.196471 | 0.707 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.101550 | 0.993 |
| R-HSA-5260271 | Diseases of Immune System | 0.080136 | 1.096 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.080136 | 1.096 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.101550 | 0.993 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.182058 | 0.740 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.094989 | 1.022 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.141798 | 0.848 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.189185 | 0.723 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.118198 | 0.927 |
| R-HSA-392518 | Signal amplification | 0.063336 | 1.198 |
| R-HSA-9671793 | Diseases of hemostasis | 0.212304 | 0.673 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.057884 | 1.237 |
| R-HSA-187015 | Activation of TRKA receptors | 0.094612 | 1.024 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.112438 | 0.949 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.112438 | 0.949 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.147051 | 0.833 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.147051 | 0.833 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.163851 | 0.786 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.180322 | 0.744 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.212304 | 0.673 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.107677 | 0.968 |
| R-HSA-68882 | Mitotic Anaphase | 0.031349 | 1.504 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.031902 | 1.496 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.172128 | 0.764 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.095569 | 1.020 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.095569 | 1.020 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.095569 | 1.020 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.060667 | 1.217 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.120348 | 0.920 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.122511 | 0.912 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.147207 | 0.832 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.227826 | 0.642 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.058211 | 1.235 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.122511 | 0.912 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.147207 | 0.832 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.154207 | 0.812 |
| R-HSA-69275 | G2/M Transition | 0.054866 | 1.261 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.111840 | 0.951 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.067203 | 1.173 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.076429 | 1.117 |
| R-HSA-164944 | Nef and signal transduction | 0.085565 | 1.068 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.094612 | 1.024 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.094612 | 1.024 |
| R-HSA-448706 | Interleukin-1 processing | 0.112438 | 0.949 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.129916 | 0.886 |
| R-HSA-8949664 | Processing of SMDT1 | 0.155493 | 0.808 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.220103 | 0.657 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.120348 | 0.920 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.056720 | 1.246 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.129086 | 0.889 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.203547 | 0.691 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.154207 | 0.812 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.135785 | 0.867 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.028480 | 1.545 |
| R-HSA-9909396 | Circadian clock | 0.183183 | 0.737 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.136972 | 0.863 |
| R-HSA-5617833 | Cilium Assembly | 0.058611 | 1.232 |
| R-HSA-68875 | Mitotic Prophase | 0.149528 | 0.825 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.069172 | 1.160 |
| R-HSA-449147 | Signaling by Interleukins | 0.028409 | 1.547 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.076429 | 1.117 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.112438 | 0.949 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.180322 | 0.744 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.196471 | 0.707 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.204427 | 0.689 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.220103 | 0.657 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.158931 | 0.799 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.037808 | 1.422 |
| R-HSA-69206 | G1/S Transition | 0.163699 | 0.786 |
| R-HSA-1640170 | Cell Cycle | 0.190558 | 0.720 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.122102 | 0.913 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.174974 | 0.757 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.108957 | 0.963 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.090535 | 1.043 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.174841 | 0.757 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.094612 | 1.024 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.112438 | 0.949 |
| R-HSA-210990 | PECAM1 interactions | 0.129916 | 0.886 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 0.196471 | 0.707 |
| R-HSA-198753 | ERK/MAPK targets | 0.227826 | 0.642 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.227826 | 0.642 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.210775 | 0.676 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.144827 | 0.839 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.218028 | 0.661 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.116064 | 0.935 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.129577 | 0.887 |
| R-HSA-140834 | Extrinsic Pathway of Fibrin Clot Formation | 0.057884 | 1.237 |
| R-HSA-9662001 | Defective factor VIII causes hemophilia A | 0.085565 | 1.068 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.199944 | 0.699 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.223797 | 0.650 |
| R-HSA-168255 | Influenza Infection | 0.135892 | 0.867 |
| R-HSA-109582 | Hemostasis | 0.058831 | 1.230 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.124548 | 0.905 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.116064 | 0.935 |
| R-HSA-159763 | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu... | 0.085565 | 1.068 |
| R-HSA-159782 | Removal of aminoterminal propeptides from gamma-carboxylated proteins | 0.094612 | 1.024 |
| R-HSA-159740 | Gamma-carboxylation of protein precursors | 0.138526 | 0.858 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.040851 | 1.389 |
| R-HSA-159854 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | 0.147051 | 0.833 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.147051 | 0.833 |
| R-HSA-9842663 | Signaling by LTK | 0.147051 | 0.833 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.172128 | 0.764 |
| R-HSA-9629569 | Protein hydroxylation | 0.220103 | 0.657 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 0.227826 | 0.642 |
| R-HSA-210991 | Basigin interactions | 0.227826 | 0.642 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.043169 | 1.365 |
| R-HSA-450294 | MAP kinase activation | 0.150576 | 0.822 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.083058 | 1.081 |
| R-HSA-445144 | Signal transduction by L1 | 0.220103 | 0.657 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.102519 | 0.989 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.101773 | 0.992 |
| R-HSA-448424 | Interleukin-17 signaling | 0.182058 | 0.740 |
| R-HSA-162582 | Signal Transduction | 0.052154 | 1.283 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.163851 | 0.786 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.071770 | 1.144 |
| R-HSA-422475 | Axon guidance | 0.202873 | 0.693 |
| R-HSA-373753 | Nephrin family interactions | 0.026075 | 1.584 |
| R-HSA-417957 | P2Y receptors | 0.163851 | 0.786 |
| R-HSA-9833482 | PKR-mediated signaling | 0.058211 | 1.235 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.060667 | 1.217 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.029401 | 1.532 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.029031 | 1.537 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.196471 | 0.707 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.125490 | 0.901 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.125490 | 0.901 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.064497 | 1.190 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.182058 | 0.740 |
| R-HSA-418990 | Adherens junctions interactions | 0.090008 | 1.046 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.212304 | 0.673 |
| R-HSA-446728 | Cell junction organization | 0.078158 | 1.107 |
| R-HSA-421270 | Cell-cell junction organization | 0.134349 | 0.872 |
| R-HSA-1500931 | Cell-Cell communication | 0.051643 | 1.287 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.184103 | 0.735 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.157477 | 0.803 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.160949 | 0.793 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.214398 | 0.669 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.151862 | 0.819 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.207158 | 0.684 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.162941 | 0.788 |
| R-HSA-9679506 | SARS-CoV Infections | 0.215791 | 0.666 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.113944 | 0.943 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.228947 | 0.640 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.228999 | 0.640 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.235473 | 0.628 |
| R-HSA-211979 | Eicosanoids | 0.235473 | 0.628 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.235473 | 0.628 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.236247 | 0.627 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.236845 | 0.626 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.239470 | 0.621 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.239903 | 0.620 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.243045 | 0.614 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.243045 | 0.614 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.243045 | 0.614 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.243045 | 0.614 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.243045 | 0.614 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.246692 | 0.608 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.247221 | 0.607 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.250542 | 0.601 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.250542 | 0.601 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.250542 | 0.601 |
| R-HSA-3000170 | Syndecan interactions | 0.250542 | 0.601 |
| R-HSA-9675108 | Nervous system development | 0.252153 | 0.598 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.254548 | 0.594 |
| R-HSA-9711097 | Cellular response to starvation | 0.255324 | 0.593 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.255324 | 0.593 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.257965 | 0.588 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.257965 | 0.588 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.257965 | 0.588 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.257965 | 0.588 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.260643 | 0.584 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.265315 | 0.576 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.265315 | 0.576 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.265315 | 0.576 |
| R-HSA-391251 | Protein folding | 0.269213 | 0.570 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.272593 | 0.564 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.272593 | 0.564 |
| R-HSA-70635 | Urea cycle | 0.272593 | 0.564 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.272879 | 0.564 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.274913 | 0.561 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.276545 | 0.558 |
| R-HSA-4839726 | Chromatin organization | 0.279305 | 0.554 |
| R-HSA-5619102 | SLC transporter disorders | 0.279364 | 0.554 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.279800 | 0.553 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.279800 | 0.553 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.279800 | 0.553 |
| R-HSA-8949613 | Cristae formation | 0.279800 | 0.553 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.279800 | 0.553 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.279800 | 0.553 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.279800 | 0.553 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.279800 | 0.553 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.280210 | 0.553 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.286935 | 0.542 |
| R-HSA-622312 | Inflammasomes | 0.286935 | 0.542 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.290122 | 0.537 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.294000 | 0.532 |
| R-HSA-180024 | DARPP-32 events | 0.294000 | 0.532 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.294000 | 0.532 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.294000 | 0.532 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.295513 | 0.529 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.298509 | 0.525 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.300995 | 0.521 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.300995 | 0.521 |
| R-HSA-2424491 | DAP12 signaling | 0.300995 | 0.521 |
| R-HSA-70171 | Glycolysis | 0.302162 | 0.520 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.303611 | 0.518 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.307922 | 0.512 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.307922 | 0.512 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.307922 | 0.512 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.309457 | 0.509 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.309457 | 0.509 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.314780 | 0.502 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.314780 | 0.502 |
| R-HSA-69190 | DNA strand elongation | 0.314780 | 0.502 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.314780 | 0.502 |
| R-HSA-111885 | Opioid Signalling | 0.316736 | 0.499 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.321571 | 0.493 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.321571 | 0.493 |
| R-HSA-354192 | Integrin signaling | 0.321571 | 0.493 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.321571 | 0.493 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.321571 | 0.493 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.321571 | 0.493 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.321571 | 0.493 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.321571 | 0.493 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.321571 | 0.493 |
| R-HSA-418346 | Platelet homeostasis | 0.327623 | 0.485 |
| R-HSA-390522 | Striated Muscle Contraction | 0.328295 | 0.484 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.328295 | 0.484 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.328295 | 0.484 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.328295 | 0.484 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.328295 | 0.484 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.328295 | 0.484 |
| R-HSA-69239 | Synthesis of DNA | 0.331242 | 0.480 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.334856 | 0.475 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.334953 | 0.475 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.334953 | 0.475 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.334953 | 0.475 |
| R-HSA-5673000 | RAF activation | 0.334953 | 0.475 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.334953 | 0.475 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.338464 | 0.470 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.338779 | 0.470 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.341545 | 0.467 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.341545 | 0.467 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.341545 | 0.467 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.341545 | 0.467 |
| R-HSA-169911 | Regulation of Apoptosis | 0.341545 | 0.467 |
| R-HSA-8953854 | Metabolism of RNA | 0.345894 | 0.461 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.346891 | 0.460 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.348072 | 0.458 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.348072 | 0.458 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.348072 | 0.458 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.348072 | 0.458 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.348072 | 0.458 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.354535 | 0.450 |
| R-HSA-4641258 | Degradation of DVL | 0.354535 | 0.450 |
| R-HSA-4641257 | Degradation of AXIN | 0.354535 | 0.450 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.354535 | 0.450 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.360934 | 0.443 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.360934 | 0.443 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.360934 | 0.443 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.367270 | 0.435 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.367270 | 0.435 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.367270 | 0.435 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.367270 | 0.435 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.367270 | 0.435 |
| R-HSA-201556 | Signaling by ALK | 0.367270 | 0.435 |
| R-HSA-69541 | Stabilization of p53 | 0.367270 | 0.435 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.367270 | 0.435 |
| R-HSA-373760 | L1CAM interactions | 0.370647 | 0.431 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.373544 | 0.428 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.373544 | 0.428 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.373544 | 0.428 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.373544 | 0.428 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.373544 | 0.428 |
| R-HSA-202433 | Generation of second messenger molecules | 0.373544 | 0.428 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.373544 | 0.428 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.373544 | 0.428 |
| R-HSA-71240 | Tryptophan catabolism | 0.373544 | 0.428 |
| R-HSA-913531 | Interferon Signaling | 0.373954 | 0.427 |
| R-HSA-70326 | Glucose metabolism | 0.374187 | 0.427 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.376537 | 0.424 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.379221 | 0.421 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.379756 | 0.420 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.379756 | 0.420 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.379756 | 0.420 |
| R-HSA-9694548 | Maturation of spike protein | 0.379756 | 0.420 |
| R-HSA-9607240 | FLT3 Signaling | 0.379756 | 0.420 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.385906 | 0.414 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.385906 | 0.414 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.385906 | 0.414 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.385906 | 0.414 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.385906 | 0.414 |
| R-HSA-189451 | Heme biosynthesis | 0.385906 | 0.414 |
| R-HSA-3371556 | Cellular response to heat stress | 0.388263 | 0.411 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.391997 | 0.407 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.391997 | 0.407 |
| R-HSA-111996 | Ca-dependent events | 0.391997 | 0.407 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.391997 | 0.407 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.398027 | 0.400 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.398027 | 0.400 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.398027 | 0.400 |
| R-HSA-1643685 | Disease | 0.398413 | 0.400 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.403997 | 0.394 |
| R-HSA-2172127 | DAP12 interactions | 0.403997 | 0.394 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.403997 | 0.394 |
| R-HSA-9907900 | Proteasome assembly | 0.403997 | 0.394 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.403997 | 0.394 |
| R-HSA-69236 | G1 Phase | 0.403997 | 0.394 |
| R-HSA-5683826 | Surfactant metabolism | 0.403997 | 0.394 |
| R-HSA-774815 | Nucleosome assembly | 0.409909 | 0.387 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.409909 | 0.387 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.409909 | 0.387 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.409909 | 0.387 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.409909 | 0.387 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.409909 | 0.387 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.409909 | 0.387 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.409909 | 0.387 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.409909 | 0.387 |
| R-HSA-9824272 | Somitogenesis | 0.409909 | 0.387 |
| R-HSA-69481 | G2/M Checkpoints | 0.412556 | 0.385 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.415762 | 0.381 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.415762 | 0.381 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.415762 | 0.381 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.415762 | 0.381 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.415762 | 0.381 |
| R-HSA-75153 | Apoptotic execution phase | 0.415762 | 0.381 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.415989 | 0.381 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.421558 | 0.375 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.421558 | 0.375 |
| R-HSA-9766229 | Degradation of CDH1 | 0.432979 | 0.364 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.432979 | 0.364 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.432979 | 0.364 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.438605 | 0.358 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.438605 | 0.358 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.442698 | 0.354 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.444176 | 0.352 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.444176 | 0.352 |
| R-HSA-162906 | HIV Infection | 0.445293 | 0.351 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.449691 | 0.347 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.449691 | 0.347 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.449691 | 0.347 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.449691 | 0.347 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.449691 | 0.347 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.450706 | 0.346 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.455152 | 0.342 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.455152 | 0.342 |
| R-HSA-1221632 | Meiotic synapsis | 0.455152 | 0.342 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.455152 | 0.342 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.455152 | 0.342 |
| R-HSA-72312 | rRNA processing | 0.458200 | 0.339 |
| R-HSA-2262752 | Cellular responses to stress | 0.458690 | 0.338 |
| R-HSA-6807070 | PTEN Regulation | 0.459655 | 0.338 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.460560 | 0.337 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.465914 | 0.332 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.465914 | 0.332 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.465914 | 0.332 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.471215 | 0.327 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.471215 | 0.327 |
| R-HSA-75893 | TNF signaling | 0.471215 | 0.327 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.471215 | 0.327 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.472711 | 0.325 |
| R-HSA-1483166 | Synthesis of PA | 0.476464 | 0.322 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.486807 | 0.313 |
| R-HSA-9033241 | Peroxisomal protein import | 0.486807 | 0.313 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.491902 | 0.308 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.491902 | 0.308 |
| R-HSA-351202 | Metabolism of polyamines | 0.491902 | 0.308 |
| R-HSA-69242 | S Phase | 0.491938 | 0.308 |
| R-HSA-166520 | Signaling by NTRKs | 0.491938 | 0.308 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.496947 | 0.304 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.496947 | 0.304 |
| R-HSA-112043 | PLC beta mediated events | 0.496947 | 0.304 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.496947 | 0.304 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.498249 | 0.303 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.498249 | 0.303 |
| R-HSA-1268020 | Mitochondrial protein import | 0.501942 | 0.299 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.501942 | 0.299 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.501942 | 0.299 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.501942 | 0.299 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.501942 | 0.299 |
| R-HSA-2142753 | Arachidonate metabolism | 0.504511 | 0.297 |
| R-HSA-6799198 | Complex I biogenesis | 0.506888 | 0.295 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.506888 | 0.295 |
| R-HSA-69306 | DNA Replication | 0.507623 | 0.294 |
| R-HSA-9609507 | Protein localization | 0.507623 | 0.294 |
| R-HSA-73887 | Death Receptor Signaling | 0.510722 | 0.292 |
| R-HSA-1989781 | PPARA activates gene expression | 0.513808 | 0.289 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.516633 | 0.287 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.519943 | 0.284 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.521434 | 0.283 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.526187 | 0.279 |
| R-HSA-112040 | G-protein mediated events | 0.526187 | 0.279 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.531295 | 0.275 |
| R-HSA-109581 | Apoptosis | 0.535054 | 0.272 |
| R-HSA-416476 | G alpha (q) signalling events | 0.537468 | 0.270 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.540168 | 0.267 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.540168 | 0.267 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.544736 | 0.264 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.544736 | 0.264 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.544736 | 0.264 |
| R-HSA-3000178 | ECM proteoglycans | 0.544736 | 0.264 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.544736 | 0.264 |
| R-HSA-189445 | Metabolism of porphyrins | 0.544736 | 0.264 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.546915 | 0.262 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.549260 | 0.260 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.549260 | 0.260 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.549260 | 0.260 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.549260 | 0.260 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.553738 | 0.257 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.553738 | 0.257 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.558173 | 0.253 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.562564 | 0.250 |
| R-HSA-5689603 | UCH proteinases | 0.566911 | 0.246 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.571215 | 0.243 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.572312 | 0.242 |
| R-HSA-216083 | Integrin cell surface interactions | 0.575477 | 0.240 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.575477 | 0.240 |
| R-HSA-5619084 | ABC transporter disorders | 0.575477 | 0.240 |
| R-HSA-4086400 | PCP/CE pathway | 0.575477 | 0.240 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.575617 | 0.240 |
| R-HSA-611105 | Respiratory electron transport | 0.583970 | 0.234 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.592108 | 0.228 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.593047 | 0.227 |
| R-HSA-9824446 | Viral Infection Pathways | 0.593641 | 0.226 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.597621 | 0.224 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.600178 | 0.222 |
| R-HSA-1500620 | Meiosis | 0.604154 | 0.219 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.604154 | 0.219 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.605651 | 0.218 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.611988 | 0.213 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.611988 | 0.213 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.619668 | 0.208 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.626473 | 0.203 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.627197 | 0.203 |
| R-HSA-9609690 | HCMV Early Events | 0.631544 | 0.200 |
| R-HSA-392499 | Metabolism of proteins | 0.633228 | 0.198 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.638213 | 0.195 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.638213 | 0.195 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.644251 | 0.191 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.652400 | 0.185 |
| R-HSA-72172 | mRNA Splicing | 0.653707 | 0.185 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.655859 | 0.183 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.655859 | 0.183 |
| R-HSA-5357801 | Programmed Cell Death | 0.656103 | 0.183 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.659284 | 0.181 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.662676 | 0.179 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.664727 | 0.177 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.666033 | 0.177 |
| R-HSA-8957322 | Metabolism of steroids | 0.666650 | 0.176 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.669358 | 0.174 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.669358 | 0.174 |
| R-HSA-397014 | Muscle contraction | 0.672510 | 0.172 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.674802 | 0.171 |
| R-HSA-1483255 | PI Metabolism | 0.675909 | 0.170 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.679136 | 0.168 |
| R-HSA-1474244 | Extracellular matrix organization | 0.679891 | 0.168 |
| R-HSA-8951664 | Neddylation | 0.692673 | 0.159 |
| R-HSA-211000 | Gene Silencing by RNA | 0.694797 | 0.158 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.697837 | 0.156 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.700847 | 0.154 |
| R-HSA-6798695 | Neutrophil degranulation | 0.702099 | 0.154 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.703827 | 0.153 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.709699 | 0.149 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.721098 | 0.142 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.723877 | 0.140 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.725998 | 0.139 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.729354 | 0.137 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.729354 | 0.137 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.734723 | 0.134 |
| R-HSA-1280218 | Adaptive Immune System | 0.739521 | 0.131 |
| R-HSA-73886 | Chromosome Maintenance | 0.739986 | 0.131 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.747686 | 0.126 |
| R-HSA-9609646 | HCMV Infection | 0.750794 | 0.124 |
| R-HSA-194138 | Signaling by VEGF | 0.752694 | 0.123 |
| R-HSA-1474165 | Reproduction | 0.767131 | 0.115 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.767679 | 0.115 |
| R-HSA-9843745 | Adipogenesis | 0.769454 | 0.114 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.771754 | 0.113 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.771754 | 0.113 |
| R-HSA-372790 | Signaling by GPCR | 0.774485 | 0.111 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.782918 | 0.106 |
| R-HSA-5368287 | Mitochondrial translation | 0.787230 | 0.104 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.787230 | 0.104 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.791457 | 0.102 |
| R-HSA-9664407 | Parasite infection | 0.791457 | 0.102 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.791457 | 0.102 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.793540 | 0.100 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.797642 | 0.098 |
| R-HSA-199991 | Membrane Trafficking | 0.798234 | 0.098 |
| R-HSA-418594 | G alpha (i) signalling events | 0.800516 | 0.097 |
| R-HSA-8978868 | Fatty acid metabolism | 0.800516 | 0.097 |
| R-HSA-9658195 | Leishmania infection | 0.802279 | 0.096 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.802279 | 0.096 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.803772 | 0.095 |
| R-HSA-388396 | GPCR downstream signalling | 0.806299 | 0.094 |
| R-HSA-9758941 | Gastrulation | 0.811373 | 0.091 |
| R-HSA-5663205 | Infectious disease | 0.814548 | 0.089 |
| R-HSA-1483257 | Phospholipid metabolism | 0.822293 | 0.085 |
| R-HSA-9610379 | HCMV Late Events | 0.825935 | 0.083 |
| R-HSA-162587 | HIV Life Cycle | 0.825935 | 0.083 |
| R-HSA-195721 | Signaling by WNT | 0.826340 | 0.083 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.842575 | 0.074 |
| R-HSA-72306 | tRNA processing | 0.848780 | 0.071 |
| R-HSA-418555 | G alpha (s) signalling events | 0.850293 | 0.070 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.853273 | 0.069 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.854741 | 0.068 |
| R-HSA-500792 | GPCR ligand binding | 0.859229 | 0.066 |
| R-HSA-2559583 | Cellular Senescence | 0.863249 | 0.064 |
| R-HSA-168249 | Innate Immune System | 0.870826 | 0.060 |
| R-HSA-983712 | Ion channel transport | 0.875090 | 0.058 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.875910 | 0.058 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.878806 | 0.056 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.888187 | 0.051 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.891515 | 0.050 |
| R-HSA-6805567 | Keratinization | 0.895801 | 0.048 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.895922 | 0.048 |
| R-HSA-168256 | Immune System | 0.907284 | 0.042 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.917372 | 0.037 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.918201 | 0.037 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.918732 | 0.037 |
| R-HSA-212436 | Generic Transcription Pathway | 0.920002 | 0.036 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.921702 | 0.035 |
| R-HSA-15869 | Metabolism of nucleotides | 0.923009 | 0.035 |
| R-HSA-157118 | Signaling by NOTCH | 0.926056 | 0.033 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.928216 | 0.032 |
| R-HSA-5688426 | Deubiquitination | 0.936455 | 0.029 |
| R-HSA-74160 | Gene expression (Transcription) | 0.939904 | 0.027 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.949646 | 0.022 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.951703 | 0.021 |
| R-HSA-597592 | Post-translational protein modification | 0.952452 | 0.021 |
| R-HSA-112316 | Neuronal System | 0.956737 | 0.019 |
| R-HSA-1266738 | Developmental Biology | 0.962028 | 0.017 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.968091 | 0.014 |
| R-HSA-382551 | Transport of small molecules | 0.973453 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.978967 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.984025 | 0.007 |
| R-HSA-556833 | Metabolism of lipids | 0.985683 | 0.006 |
| R-HSA-211859 | Biological oxidations | 0.995908 | 0.002 |
| R-HSA-1430728 | Metabolism | 0.999822 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.868 | 0.332 | 1 | 0.895 |
COT |
0.865 | 0.090 | 2 | 0.864 |
NLK |
0.863 | 0.380 | 1 | 0.907 |
CDK8 |
0.861 | 0.399 | 1 | 0.866 |
KIS |
0.860 | 0.328 | 1 | 0.882 |
CDK19 |
0.859 | 0.402 | 1 | 0.849 |
HIPK4 |
0.859 | 0.299 | 1 | 0.837 |
ERK5 |
0.858 | 0.262 | 1 | 0.881 |
ICK |
0.856 | 0.318 | -3 | 0.788 |
CDK18 |
0.856 | 0.421 | 1 | 0.845 |
PIM3 |
0.856 | 0.114 | -3 | 0.771 |
CDK7 |
0.855 | 0.384 | 1 | 0.881 |
CDKL5 |
0.855 | 0.202 | -3 | 0.750 |
SRPK1 |
0.854 | 0.213 | -3 | 0.718 |
MTOR |
0.854 | 0.088 | 1 | 0.782 |
JNK2 |
0.854 | 0.438 | 1 | 0.854 |
CDKL1 |
0.854 | 0.163 | -3 | 0.754 |
DYRK2 |
0.853 | 0.384 | 1 | 0.861 |
MOS |
0.852 | 0.075 | 1 | 0.797 |
CDC7 |
0.852 | -0.003 | 1 | 0.765 |
NDR2 |
0.852 | 0.063 | -3 | 0.780 |
CDK5 |
0.852 | 0.398 | 1 | 0.891 |
P38A |
0.852 | 0.438 | 1 | 0.895 |
P38B |
0.852 | 0.439 | 1 | 0.864 |
CDK1 |
0.851 | 0.379 | 1 | 0.861 |
CDK17 |
0.849 | 0.400 | 1 | 0.813 |
HIPK2 |
0.849 | 0.402 | 1 | 0.813 |
ERK1 |
0.849 | 0.410 | 1 | 0.857 |
PRKD1 |
0.849 | 0.112 | -3 | 0.811 |
SKMLCK |
0.849 | 0.180 | -2 | 0.914 |
P38G |
0.848 | 0.413 | 1 | 0.807 |
JNK3 |
0.848 | 0.409 | 1 | 0.866 |
CDK13 |
0.847 | 0.357 | 1 | 0.863 |
PRPK |
0.847 | -0.087 | -1 | 0.861 |
RSK2 |
0.846 | 0.110 | -3 | 0.726 |
CAMK1B |
0.846 | 0.062 | -3 | 0.790 |
ATR |
0.845 | 0.041 | 1 | 0.770 |
RAF1 |
0.845 | -0.070 | 1 | 0.750 |
CDK3 |
0.844 | 0.364 | 1 | 0.827 |
SRPK2 |
0.844 | 0.165 | -3 | 0.645 |
HIPK1 |
0.844 | 0.374 | 1 | 0.868 |
DSTYK |
0.843 | -0.058 | 2 | 0.864 |
PIM1 |
0.843 | 0.108 | -3 | 0.722 |
CLK2 |
0.842 | 0.301 | -3 | 0.697 |
CAMLCK |
0.842 | 0.158 | -2 | 0.912 |
CLK4 |
0.842 | 0.274 | -3 | 0.704 |
CDK14 |
0.842 | 0.409 | 1 | 0.869 |
GCN2 |
0.842 | -0.149 | 2 | 0.782 |
IKKB |
0.842 | -0.126 | -2 | 0.749 |
DYRK1A |
0.842 | 0.347 | 1 | 0.883 |
DAPK2 |
0.842 | 0.150 | -3 | 0.796 |
AURC |
0.842 | 0.209 | -2 | 0.777 |
DYRK4 |
0.842 | 0.387 | 1 | 0.838 |
TBK1 |
0.842 | -0.079 | 1 | 0.657 |
CDK12 |
0.842 | 0.362 | 1 | 0.846 |
P90RSK |
0.842 | 0.080 | -3 | 0.729 |
NDR1 |
0.841 | 0.036 | -3 | 0.768 |
PKN3 |
0.841 | 0.024 | -3 | 0.765 |
BMPR2 |
0.841 | -0.108 | -2 | 0.882 |
RSK3 |
0.841 | 0.087 | -3 | 0.730 |
PDHK4 |
0.840 | -0.187 | 1 | 0.781 |
CDK16 |
0.840 | 0.398 | 1 | 0.822 |
P38D |
0.840 | 0.415 | 1 | 0.817 |
MARK4 |
0.840 | 0.063 | 4 | 0.880 |
CLK1 |
0.840 | 0.262 | -3 | 0.696 |
PRKD2 |
0.839 | 0.068 | -3 | 0.741 |
TGFBR2 |
0.839 | -0.016 | -2 | 0.813 |
DYRK1B |
0.839 | 0.366 | 1 | 0.857 |
NUAK2 |
0.839 | 0.026 | -3 | 0.765 |
MAK |
0.839 | 0.403 | -2 | 0.859 |
ERK2 |
0.839 | 0.363 | 1 | 0.867 |
HIPK3 |
0.838 | 0.367 | 1 | 0.859 |
CDK9 |
0.838 | 0.341 | 1 | 0.867 |
MST4 |
0.838 | 0.023 | 2 | 0.831 |
PKCD |
0.838 | 0.088 | 2 | 0.771 |
RIPK3 |
0.838 | -0.017 | 3 | 0.748 |
IKKE |
0.837 | -0.112 | 1 | 0.646 |
CAMK2G |
0.837 | -0.097 | 2 | 0.795 |
ULK2 |
0.837 | -0.144 | 2 | 0.762 |
CDK10 |
0.836 | 0.376 | 1 | 0.863 |
NIK |
0.836 | 0.004 | -3 | 0.800 |
GRK1 |
0.836 | 0.018 | -2 | 0.806 |
WNK1 |
0.836 | -0.003 | -2 | 0.891 |
NEK6 |
0.836 | -0.051 | -2 | 0.836 |
PDHK1 |
0.836 | -0.163 | 1 | 0.755 |
PKN2 |
0.835 | 0.025 | -3 | 0.770 |
SRPK3 |
0.835 | 0.127 | -3 | 0.690 |
IKKA |
0.835 | -0.049 | -2 | 0.734 |
PKACG |
0.835 | 0.092 | -2 | 0.809 |
CAMK2D |
0.834 | -0.016 | -3 | 0.785 |
LATS2 |
0.834 | -0.007 | -5 | 0.719 |
P70S6KB |
0.834 | 0.054 | -3 | 0.734 |
MAPKAPK2 |
0.834 | 0.038 | -3 | 0.698 |
CDK2 |
0.833 | 0.252 | 1 | 0.893 |
PAK1 |
0.833 | 0.130 | -2 | 0.892 |
AMPKA1 |
0.833 | 0.026 | -3 | 0.785 |
MAPKAPK3 |
0.833 | 0.007 | -3 | 0.743 |
DYRK3 |
0.833 | 0.333 | 1 | 0.849 |
PKACB |
0.832 | 0.176 | -2 | 0.776 |
BCKDK |
0.832 | -0.112 | -1 | 0.819 |
HUNK |
0.832 | -0.091 | 2 | 0.773 |
NEK7 |
0.832 | -0.161 | -3 | 0.767 |
BMPR1B |
0.832 | 0.084 | 1 | 0.734 |
MLK1 |
0.832 | -0.106 | 2 | 0.797 |
MSK2 |
0.831 | 0.082 | -3 | 0.716 |
PAK3 |
0.831 | 0.106 | -2 | 0.880 |
RSK4 |
0.831 | 0.101 | -3 | 0.693 |
LATS1 |
0.830 | 0.081 | -3 | 0.785 |
ATM |
0.830 | -0.007 | 1 | 0.705 |
MASTL |
0.830 | -0.154 | -2 | 0.823 |
CHAK2 |
0.830 | -0.053 | -1 | 0.834 |
TSSK1 |
0.829 | 0.047 | -3 | 0.806 |
AURB |
0.829 | 0.174 | -2 | 0.779 |
MSK1 |
0.829 | 0.131 | -3 | 0.713 |
MNK2 |
0.829 | 0.103 | -2 | 0.866 |
TGFBR1 |
0.829 | 0.048 | -2 | 0.817 |
MLK2 |
0.829 | -0.027 | 2 | 0.798 |
ALK4 |
0.828 | 0.020 | -2 | 0.845 |
FAM20C |
0.828 | 0.067 | 2 | 0.650 |
AMPKA2 |
0.828 | 0.020 | -3 | 0.759 |
WNK3 |
0.828 | -0.148 | 1 | 0.718 |
QSK |
0.828 | 0.060 | 4 | 0.864 |
GRK5 |
0.827 | -0.191 | -3 | 0.750 |
CAMK2B |
0.827 | -0.002 | 2 | 0.782 |
PKCA |
0.827 | 0.067 | 2 | 0.711 |
JNK1 |
0.827 | 0.347 | 1 | 0.846 |
AURA |
0.827 | 0.172 | -2 | 0.771 |
MYLK4 |
0.826 | 0.117 | -2 | 0.862 |
ANKRD3 |
0.826 | -0.107 | 1 | 0.768 |
TSSK2 |
0.826 | 0.006 | -5 | 0.789 |
CAMK2A |
0.826 | 0.010 | 2 | 0.785 |
PKG2 |
0.825 | 0.135 | -2 | 0.760 |
PRKD3 |
0.825 | 0.037 | -3 | 0.725 |
NEK9 |
0.825 | -0.144 | 2 | 0.807 |
MLK3 |
0.825 | -0.023 | 2 | 0.731 |
ULK1 |
0.825 | -0.189 | -3 | 0.744 |
NIM1 |
0.825 | -0.021 | 3 | 0.772 |
AKT2 |
0.824 | 0.114 | -3 | 0.648 |
PIM2 |
0.824 | 0.096 | -3 | 0.694 |
PKCG |
0.824 | 0.021 | 2 | 0.723 |
PKCB |
0.824 | 0.033 | 2 | 0.722 |
PAK6 |
0.824 | 0.131 | -2 | 0.827 |
CDK6 |
0.824 | 0.362 | 1 | 0.855 |
SGK3 |
0.823 | 0.105 | -3 | 0.712 |
PRKX |
0.823 | 0.140 | -3 | 0.618 |
CDK4 |
0.823 | 0.370 | 1 | 0.838 |
RIPK1 |
0.823 | -0.142 | 1 | 0.708 |
PAK2 |
0.823 | 0.092 | -2 | 0.883 |
NUAK1 |
0.823 | -0.019 | -3 | 0.729 |
PRP4 |
0.823 | 0.163 | -3 | 0.671 |
DLK |
0.823 | -0.202 | 1 | 0.748 |
GRK6 |
0.823 | -0.132 | 1 | 0.761 |
CAMK4 |
0.823 | -0.043 | -3 | 0.747 |
QIK |
0.822 | -0.032 | -3 | 0.760 |
MELK |
0.822 | -0.006 | -3 | 0.749 |
SMG1 |
0.822 | -0.008 | 1 | 0.720 |
SIK |
0.822 | 0.016 | -3 | 0.708 |
IRE1 |
0.821 | -0.074 | 1 | 0.689 |
GRK7 |
0.821 | 0.004 | 1 | 0.725 |
DNAPK |
0.820 | 0.025 | 1 | 0.660 |
MNK1 |
0.820 | 0.067 | -2 | 0.866 |
PKR |
0.820 | -0.043 | 1 | 0.746 |
VRK2 |
0.820 | -0.005 | 1 | 0.807 |
MARK3 |
0.820 | 0.043 | 4 | 0.829 |
MARK2 |
0.820 | 0.042 | 4 | 0.800 |
PKCZ |
0.820 | 0.015 | 2 | 0.755 |
IRE2 |
0.819 | -0.030 | 2 | 0.742 |
PLK1 |
0.819 | -0.087 | -2 | 0.806 |
BRSK1 |
0.819 | -0.007 | -3 | 0.744 |
PHKG1 |
0.818 | -0.048 | -3 | 0.763 |
MOK |
0.818 | 0.305 | 1 | 0.844 |
MPSK1 |
0.818 | 0.172 | 1 | 0.743 |
ACVR2B |
0.817 | -0.025 | -2 | 0.801 |
MEK1 |
0.817 | -0.146 | 2 | 0.806 |
GRK4 |
0.817 | -0.204 | -2 | 0.823 |
ALK2 |
0.817 | -0.011 | -2 | 0.821 |
PKACA |
0.817 | 0.146 | -2 | 0.727 |
PKCH |
0.816 | -0.004 | 2 | 0.704 |
ACVR2A |
0.816 | -0.037 | -2 | 0.795 |
YSK4 |
0.816 | -0.133 | 1 | 0.683 |
BRSK2 |
0.816 | -0.043 | -3 | 0.756 |
TTBK2 |
0.816 | -0.209 | 2 | 0.682 |
CHK1 |
0.815 | -0.051 | -3 | 0.762 |
ERK7 |
0.815 | 0.147 | 2 | 0.542 |
MLK4 |
0.815 | -0.087 | 2 | 0.717 |
SMMLCK |
0.814 | 0.089 | -3 | 0.760 |
AKT1 |
0.814 | 0.124 | -3 | 0.662 |
NEK2 |
0.814 | -0.091 | 2 | 0.778 |
DRAK1 |
0.813 | -0.062 | 1 | 0.719 |
DCAMKL1 |
0.813 | 0.006 | -3 | 0.735 |
PINK1 |
0.813 | -0.026 | 1 | 0.814 |
MARK1 |
0.812 | -0.004 | 4 | 0.840 |
BMPR1A |
0.812 | 0.025 | 1 | 0.708 |
TLK2 |
0.812 | -0.094 | 1 | 0.693 |
CAMK1G |
0.811 | -0.018 | -3 | 0.709 |
PLK3 |
0.810 | -0.117 | 2 | 0.752 |
DAPK3 |
0.809 | 0.129 | -3 | 0.737 |
CHAK1 |
0.809 | -0.161 | 2 | 0.737 |
MEKK1 |
0.808 | -0.110 | 1 | 0.722 |
PLK4 |
0.808 | -0.091 | 2 | 0.605 |
MST3 |
0.808 | -0.008 | 2 | 0.808 |
PKCT |
0.808 | 0.029 | 2 | 0.711 |
GRK2 |
0.808 | -0.081 | -2 | 0.723 |
BRAF |
0.808 | -0.087 | -4 | 0.836 |
SNRK |
0.808 | -0.133 | 2 | 0.651 |
MAPKAPK5 |
0.807 | -0.104 | -3 | 0.692 |
PAK5 |
0.807 | 0.105 | -2 | 0.791 |
HRI |
0.806 | -0.162 | -2 | 0.844 |
NEK5 |
0.806 | -0.079 | 1 | 0.740 |
PAK4 |
0.806 | 0.122 | -2 | 0.805 |
PASK |
0.806 | -0.007 | -3 | 0.788 |
TAO3 |
0.806 | -0.048 | 1 | 0.728 |
MEK5 |
0.805 | -0.195 | 2 | 0.795 |
AKT3 |
0.805 | 0.124 | -3 | 0.605 |
MEKK2 |
0.805 | -0.111 | 2 | 0.782 |
P70S6K |
0.805 | -0.004 | -3 | 0.667 |
SSTK |
0.804 | 0.020 | 4 | 0.848 |
GSK3A |
0.804 | 0.057 | 4 | 0.366 |
ZAK |
0.804 | -0.151 | 1 | 0.682 |
PERK |
0.804 | -0.163 | -2 | 0.822 |
CAMK1D |
0.804 | 0.023 | -3 | 0.645 |
WNK4 |
0.804 | -0.103 | -2 | 0.876 |
GAK |
0.803 | 0.055 | 1 | 0.818 |
PKCI |
0.803 | 0.025 | 2 | 0.724 |
DAPK1 |
0.803 | 0.116 | -3 | 0.722 |
DCAMKL2 |
0.803 | -0.043 | -3 | 0.749 |
CK1E |
0.802 | -0.081 | -3 | 0.453 |
IRAK4 |
0.802 | -0.095 | 1 | 0.687 |
SGK1 |
0.802 | 0.103 | -3 | 0.580 |
PKCE |
0.801 | 0.049 | 2 | 0.707 |
PHKG2 |
0.800 | -0.062 | -3 | 0.733 |
LKB1 |
0.800 | -0.027 | -3 | 0.764 |
TLK1 |
0.800 | -0.143 | -2 | 0.820 |
MEKK3 |
0.800 | -0.235 | 1 | 0.727 |
MRCKB |
0.799 | 0.107 | -3 | 0.684 |
GSK3B |
0.799 | -0.014 | 4 | 0.358 |
GCK |
0.798 | -0.028 | 1 | 0.739 |
SBK |
0.798 | 0.085 | -3 | 0.552 |
PKN1 |
0.798 | 0.017 | -3 | 0.682 |
MRCKA |
0.797 | 0.095 | -3 | 0.691 |
ROCK2 |
0.797 | 0.113 | -3 | 0.723 |
TAO2 |
0.797 | -0.080 | 2 | 0.817 |
MST2 |
0.796 | -0.072 | 1 | 0.735 |
NEK11 |
0.796 | -0.155 | 1 | 0.720 |
CAMKK1 |
0.796 | -0.148 | -2 | 0.749 |
MEKK6 |
0.795 | -0.029 | 1 | 0.711 |
NEK8 |
0.795 | -0.154 | 2 | 0.790 |
PDK1 |
0.795 | -0.061 | 1 | 0.716 |
TNIK |
0.795 | 0.009 | 3 | 0.844 |
CAMK1A |
0.795 | 0.044 | -3 | 0.633 |
CAMKK2 |
0.795 | -0.104 | -2 | 0.751 |
CK1D |
0.795 | -0.078 | -3 | 0.404 |
CHK2 |
0.794 | 0.013 | -3 | 0.604 |
CK2A2 |
0.794 | -0.015 | 1 | 0.665 |
PBK |
0.794 | 0.090 | 1 | 0.765 |
HGK |
0.794 | -0.029 | 3 | 0.848 |
DMPK1 |
0.793 | 0.148 | -3 | 0.697 |
HPK1 |
0.792 | -0.025 | 1 | 0.721 |
MAP3K15 |
0.792 | -0.059 | 1 | 0.675 |
MINK |
0.792 | -0.059 | 1 | 0.704 |
GRK3 |
0.792 | -0.098 | -2 | 0.682 |
NEK4 |
0.791 | -0.108 | 1 | 0.701 |
KHS1 |
0.791 | 0.020 | 1 | 0.701 |
IRAK1 |
0.790 | -0.236 | -1 | 0.737 |
EEF2K |
0.790 | -0.060 | 3 | 0.822 |
CK1A2 |
0.790 | -0.088 | -3 | 0.405 |
TAK1 |
0.790 | -0.103 | 1 | 0.723 |
CK1G1 |
0.789 | -0.132 | -3 | 0.441 |
KHS2 |
0.788 | 0.016 | 1 | 0.723 |
NEK1 |
0.788 | -0.075 | 1 | 0.704 |
TTBK1 |
0.788 | -0.209 | 2 | 0.604 |
BUB1 |
0.788 | 0.061 | -5 | 0.733 |
LRRK2 |
0.788 | -0.118 | 2 | 0.812 |
VRK1 |
0.787 | -0.106 | 2 | 0.808 |
LOK |
0.787 | -0.061 | -2 | 0.783 |
PLK2 |
0.786 | -0.077 | -3 | 0.707 |
PKG1 |
0.785 | 0.078 | -2 | 0.683 |
MST1 |
0.785 | -0.124 | 1 | 0.711 |
ROCK1 |
0.783 | 0.094 | -3 | 0.692 |
PDHK3_TYR |
0.782 | 0.177 | 4 | 0.880 |
CK2A1 |
0.782 | -0.037 | 1 | 0.646 |
YSK1 |
0.782 | -0.070 | 2 | 0.779 |
SLK |
0.782 | -0.102 | -2 | 0.733 |
BIKE |
0.782 | 0.110 | 1 | 0.737 |
MEK2 |
0.780 | -0.187 | 2 | 0.774 |
CRIK |
0.778 | 0.051 | -3 | 0.667 |
RIPK2 |
0.778 | -0.227 | 1 | 0.648 |
OSR1 |
0.777 | -0.069 | 2 | 0.773 |
STK33 |
0.776 | -0.175 | 2 | 0.599 |
TTK |
0.774 | -0.062 | -2 | 0.828 |
NEK3 |
0.774 | -0.126 | 1 | 0.668 |
MAP2K4_TYR |
0.774 | 0.027 | -1 | 0.886 |
PKMYT1_TYR |
0.774 | 0.096 | 3 | 0.849 |
MYO3B |
0.773 | -0.017 | 2 | 0.797 |
PDHK4_TYR |
0.773 | 0.026 | 2 | 0.855 |
TESK1_TYR |
0.773 | -0.012 | 3 | 0.872 |
AAK1 |
0.772 | 0.161 | 1 | 0.666 |
MAP2K6_TYR |
0.772 | 0.009 | -1 | 0.885 |
LIMK2_TYR |
0.772 | 0.116 | -3 | 0.815 |
HASPIN |
0.770 | -0.040 | -1 | 0.659 |
BMPR2_TYR |
0.770 | 0.006 | -1 | 0.879 |
ASK1 |
0.770 | -0.084 | 1 | 0.659 |
MAP2K7_TYR |
0.769 | -0.127 | 2 | 0.827 |
MYO3A |
0.768 | -0.060 | 1 | 0.687 |
PDHK1_TYR |
0.767 | -0.067 | -1 | 0.893 |
YANK3 |
0.766 | -0.073 | 2 | 0.408 |
TXK |
0.766 | 0.075 | 1 | 0.786 |
EPHB4 |
0.765 | 0.008 | -1 | 0.858 |
EPHA6 |
0.765 | 0.008 | -1 | 0.865 |
TAO1 |
0.764 | -0.111 | 1 | 0.640 |
PINK1_TYR |
0.763 | -0.166 | 1 | 0.765 |
LIMK1_TYR |
0.762 | -0.067 | 2 | 0.819 |
YES1 |
0.761 | -0.003 | -1 | 0.863 |
RET |
0.761 | -0.094 | 1 | 0.716 |
MST1R |
0.761 | -0.079 | 3 | 0.799 |
ROS1 |
0.760 | -0.048 | 3 | 0.763 |
ABL2 |
0.760 | -0.012 | -1 | 0.828 |
FGR |
0.759 | -0.061 | 1 | 0.802 |
TYRO3 |
0.759 | -0.083 | 3 | 0.786 |
CSF1R |
0.758 | -0.060 | 3 | 0.779 |
BLK |
0.757 | 0.040 | -1 | 0.847 |
ALPHAK3 |
0.757 | -0.135 | -1 | 0.780 |
DDR1 |
0.756 | -0.086 | 4 | 0.820 |
TYK2 |
0.756 | -0.160 | 1 | 0.707 |
TNK2 |
0.756 | -0.007 | 3 | 0.748 |
LCK |
0.756 | 0.009 | -1 | 0.839 |
HCK |
0.756 | -0.046 | -1 | 0.841 |
JAK2 |
0.755 | -0.119 | 1 | 0.712 |
STLK3 |
0.754 | -0.183 | 1 | 0.657 |
ABL1 |
0.754 | -0.041 | -1 | 0.819 |
ITK |
0.754 | -0.044 | -1 | 0.814 |
FER |
0.754 | -0.136 | 1 | 0.798 |
SRMS |
0.753 | -0.080 | 1 | 0.773 |
CK1A |
0.753 | -0.119 | -3 | 0.317 |
JAK3 |
0.752 | -0.098 | 1 | 0.692 |
EPHA4 |
0.752 | -0.067 | 2 | 0.750 |
TNNI3K_TYR |
0.752 | -0.004 | 1 | 0.732 |
EPHB3 |
0.751 | -0.074 | -1 | 0.842 |
EPHB2 |
0.751 | -0.067 | -1 | 0.839 |
EPHB1 |
0.751 | -0.094 | 1 | 0.766 |
INSRR |
0.751 | -0.098 | 3 | 0.730 |
BMX |
0.750 | -0.035 | -1 | 0.750 |
FYN |
0.750 | 0.004 | -1 | 0.821 |
FGFR2 |
0.749 | -0.096 | 3 | 0.780 |
JAK1 |
0.748 | -0.059 | 1 | 0.657 |
TNK1 |
0.748 | -0.045 | 3 | 0.766 |
KDR |
0.747 | -0.082 | 3 | 0.744 |
KIT |
0.747 | -0.125 | 3 | 0.783 |
PDGFRB |
0.747 | -0.160 | 3 | 0.794 |
TEK |
0.746 | -0.103 | 3 | 0.720 |
MERTK |
0.746 | -0.077 | 3 | 0.757 |
TEC |
0.746 | -0.076 | -1 | 0.764 |
MET |
0.745 | -0.098 | 3 | 0.767 |
FGFR1 |
0.745 | -0.106 | 3 | 0.756 |
AXL |
0.745 | -0.114 | 3 | 0.763 |
NEK10_TYR |
0.745 | -0.106 | 1 | 0.583 |
EPHA7 |
0.744 | -0.072 | 2 | 0.750 |
DDR2 |
0.743 | 0.014 | 3 | 0.724 |
BTK |
0.742 | -0.173 | -1 | 0.785 |
PTK2B |
0.741 | -0.035 | -1 | 0.784 |
FLT3 |
0.741 | -0.190 | 3 | 0.784 |
ALK |
0.741 | -0.120 | 3 | 0.707 |
LYN |
0.741 | -0.086 | 3 | 0.717 |
LTK |
0.740 | -0.117 | 3 | 0.734 |
SRC |
0.740 | -0.049 | -1 | 0.821 |
EPHA3 |
0.740 | -0.127 | 2 | 0.723 |
EPHA1 |
0.739 | -0.101 | 3 | 0.745 |
NTRK1 |
0.738 | -0.197 | -1 | 0.841 |
FRK |
0.738 | -0.116 | -1 | 0.847 |
PDGFRA |
0.738 | -0.217 | 3 | 0.789 |
PTK6 |
0.737 | -0.189 | -1 | 0.738 |
WEE1_TYR |
0.737 | -0.129 | -1 | 0.751 |
INSR |
0.737 | -0.138 | 3 | 0.711 |
FGFR3 |
0.736 | -0.131 | 3 | 0.749 |
NTRK3 |
0.736 | -0.124 | -1 | 0.792 |
FLT1 |
0.735 | -0.154 | -1 | 0.843 |
ERBB2 |
0.734 | -0.194 | 1 | 0.686 |
NTRK2 |
0.734 | -0.200 | 3 | 0.743 |
EPHA5 |
0.734 | -0.104 | 2 | 0.735 |
EPHA8 |
0.734 | -0.100 | -1 | 0.822 |
PTK2 |
0.733 | -0.018 | -1 | 0.803 |
MATK |
0.732 | -0.127 | -1 | 0.752 |
FLT4 |
0.732 | -0.187 | 3 | 0.743 |
EGFR |
0.730 | -0.107 | 1 | 0.607 |
YANK2 |
0.728 | -0.121 | 2 | 0.427 |
CK1G3 |
0.726 | -0.141 | -3 | 0.271 |
CSK |
0.726 | -0.162 | 2 | 0.755 |
SYK |
0.724 | -0.080 | -1 | 0.786 |
FGFR4 |
0.724 | -0.130 | -1 | 0.787 |
EPHA2 |
0.722 | -0.108 | -1 | 0.795 |
IGF1R |
0.719 | -0.155 | 3 | 0.650 |
MUSK |
0.718 | -0.152 | 1 | 0.597 |
ERBB4 |
0.718 | -0.097 | 1 | 0.638 |
FES |
0.708 | -0.151 | -1 | 0.723 |
CK1G2 |
0.705 | -0.145 | -3 | 0.362 |
ZAP70 |
0.703 | -0.084 | -1 | 0.712 |