Motif 935 (n=195)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S244 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A6NMY6 | ANXA2P2 | S22 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A6NMZ7 | COL6A6 | S819 | ochoa | Collagen alpha-6(VI) chain | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| H0Y626 | None | S62 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| O00267 | SUPT5H | S148 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O14519 | CDK2AP1 | S84 | ochoa | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| O43166 | SIPA1L1 | S318 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O60271 | SPAG9 | S185 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60437 | PPL | S949 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O75369 | FLNB | S91 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75379 | VAMP4 | S92 | ochoa | Vesicle-associated membrane protein 4 (VAMP-4) | Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. |
| O75396 | SEC22B | S174 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O75396 | SEC22B | S177 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O94823 | ATP10B | S984 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
| O94885 | SASH1 | S721 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94953 | KDM4B | S1041 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95183 | VAMP5 | S48 | ochoa | Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin) | May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. |
| O95197 | RTN3 | S649 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95361 | TRIM16 | S62 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| O95475 | SIX6 | S227 | ochoa | Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) | May be involved in eye development. |
| O96017 | CHEK2 | S140 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P02545 | LMNA | S303 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P07355 | ANXA2 | S22 | ochoa|psp | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P09038 | FGF2 | S206 | psp | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) | Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879). {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:29501879, ECO:0000269|PubMed:3732516, ECO:0000269|PubMed:3964259}. |
| P09467 | FBP1 | S88 | psp | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P11021 | HSPA5 | S86 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P12270 | TPR | S1459 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P13994 | YJU2B | S238 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
| P16871 | IL7R | S297 | ochoa | Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) | Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
| P17066 | HSPA6 | S42 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P17948 | FLT1 | Y1242 | psp | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| P20290 | BTF3 | S158 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P21333 | FLNA | S118 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23975 | SLC6A2 | S259 | psp | Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2) | Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:2008212, PubMed:8125921, PubMed:38750358). Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:11093780, PubMed:8125921, PubMed:39395208, PubMed:39048818). {ECO:0000250|UniProtKB:O55192, ECO:0000269|PubMed:11093780, ECO:0000269|PubMed:2008212, ECO:0000269|PubMed:38750358, ECO:0000269|PubMed:39048818, ECO:0000269|PubMed:8125921}. |
| P26038 | MSN | S536 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P26232 | CTNNA2 | S42 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P27348 | YWHAQ | S214 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P30414 | NKTR | S1077 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P31930 | UQCRC1 | S107 | ochoa | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179). {ECO:0000250|UniProtKB:P07256, ECO:0000250|UniProtKB:P31800, ECO:0000269|PubMed:33141179, ECO:0000305|PubMed:29243944}. |
| P31946 | YWHAB | S216 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S216 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P35222 | CTNNB1 | S718 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35240 | NF2 | S572 | ochoa | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P38398 | BRCA1 | S403 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42766 | RPL35 | S29 | ochoa | Large ribosomal subunit protein uL29 (60S ribosomal protein L35) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P45983 | MAPK8 | S179 | ochoa | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:28943315). In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation (PubMed:21856198). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:16581800, PubMed:17296730, PubMed:20027304). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (PubMed:27568560). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (PubMed:34048572). {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:18307971, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:21095239, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:28943315, ECO:0000269|PubMed:34048572}.; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. |
| P46013 | MKI67 | S1721 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46060 | RANGAP1 | S24 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P46100 | ATRX | S1244 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46976 | GYG1 | S46 | ochoa | Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) | Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase. {ECO:0000269|PubMed:22160680, ECO:0000269|PubMed:30356213}. |
| P48681 | NES | S47 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48741 | HSPA7 | S42 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P49588 | AARS1 | S484 | ochoa | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| P49815 | TSC2 | S932 | psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P51809 | VAMP7 | S168 | ochoa | Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP) | Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249, ECO:0000269|PubMed:18042464}. |
| P52630 | STAT2 | S381 | psp | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
| P52948 | NUP98 | S726 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P53779 | MAPK10 | S217 | ochoa | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}. |
| P56945 | BCAR1 | S694 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P61129 | ZC3H6 | S738 | ochoa | Zinc finger CCCH domain-containing protein 6 | None |
| P61981 | YWHAG | S219 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | S217 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S214 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P78345 | RPP38 | S235 | ochoa | Ribonuclease P protein subunit p38 (RNaseP protein p38) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}. |
| Q00341 | HDLBP | S804 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00688 | FKBP3 | S77 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q00987 | MDM2 | S118 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01974 | ROR2 | S576 | ochoa | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) | Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}. |
| Q02535 | ID3 | S65 | psp | DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}. |
| Q04917 | YWHAH | S219 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q05682 | CALD1 | S660 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q06546 | GABPA | S62 | ochoa | GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) | Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. |
| Q08499 | PDE4D | S305 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q0VF96 | CGNL1 | S261 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12905 | ILF2 | S68 | ochoa | Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) | Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12955 | ANK3 | S4181 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q12983 | BNIP3 | S144 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q13043 | STK4 | S40 | psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13573 | SNW1 | S182 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13905 | RAPGEF1 | S375 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q13976 | PRKG1 | S51 | psp | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| Q14207 | NPAT | S377 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14562 | DHX8 | S129 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q15027 | ACAP1 | S231 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}. |
| Q15056 | EIF4H | S110 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15327 | ANKRD1 | S213 | ochoa | Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein) | May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}. |
| Q15545 | TAF7 | S264 | ochoa|psp | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q15785 | TOMM34 | S231 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q16625 | OCLN | S471 | psp | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q29RF7 | PDS5A | S178 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2NL82 | TSR1 | S387 | ochoa | Pre-rRNA-processing protein TSR1 homolog | Required during maturation of the 40S ribosomal subunit in the nucleolus. {ECO:0000250}. |
| Q4LE39 | ARID4B | S919 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q5UIP0 | RIF1 | S20 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VU97 | CACHD1 | S1155 | ochoa | VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) | May regulate voltage-dependent calcium channels. {ECO:0000250}. |
| Q68DN1 | SPATA31H1 | S178 | ochoa | Spermatogenesis-associated protein 31H1 | None |
| Q6EKJ0 | GTF2IRD2B | S500 | ochoa | General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) | None |
| Q6GYQ0 | RALGAPA1 | S691 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6P0Q8 | MAST2 | S80 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6UN15 | FIP1L1 | S244 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6WKZ4 | RAB11FIP1 | S313 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6XR72 | SLC30A10 | S402 | ochoa | Calcium/manganese antiporter SLC30A10 (Solute carrier family 30 member 10) (Zinc transporter 10) (ZnT-10) | Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:26728129, PubMed:27226609, PubMed:27307044). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129). {ECO:0000269|PubMed:22341972, ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129, ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:27307044, ECO:0000269|PubMed:30755481}. |
| Q6ZS17 | RIPOR1 | S114 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q76FK4 | NOL8 | S329 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q76I76 | SSH2 | S690 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q7Z494 | NPHP3 | S1308 | ochoa | Nephrocystin-3 | Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. {ECO:0000269|PubMed:18371931}. |
| Q7Z6Z7 | HUWE1 | S2362 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86VP6 | CAND1 | S557 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86VY9 | TMEM200A | S471 | ochoa | Transmembrane protein 200A | None |
| Q8IVL1 | NAV2 | S1279 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IWP9 | CCDC28A | S241 | ochoa | Coiled-coil domain-containing protein 28A (CCRL1AP) | None |
| Q8N573 | OXR1 | S363 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5A5 | ZGPAT | S280 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N9T8 | KRI1 | S217 | ochoa | Protein KRI1 homolog | None |
| Q8NFC6 | BOD1L1 | S1100 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHV4 | NEDD1 | S108 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TDM6 | DLG5 | S972 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDY2 | RB1CC1 | S629 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TE77 | SSH3 | S85 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
| Q8TF72 | SHROOM3 | S443 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUY3 | PRUNE2 | S1613 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WZ74 | CTTNBP2 | S280 | ochoa | Cortactin-binding protein 2 (CortBP2) | Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons. {ECO:0000250|UniProtKB:Q2IBD4}. |
| Q92547 | TOPBP1 | S370 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92556 | ELMO1 | S510 | ochoa | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}. |
| Q92613 | JADE3 | S741 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92630 | DYRK2 | S449 | psp | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q92667 | AKAP1 | S69 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92786 | PROX1 | S295 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92800 | EZH1 | S490 | ochoa | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}. |
| Q92854 | SEMA4D | S800 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q92997 | DVL3 | S140 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96BD0 | SLCO4A1 | S361 | ochoa | Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) | Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}. |
| Q96CB8 | INTS12 | S50 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
| Q96K17 | BTF3L4 | S109 | ochoa | Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) | None |
| Q96K49 | TMEM87B | S494 | ochoa | Transmembrane protein 87B | May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. |
| Q96L93 | KIF16B | S575 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96QD5 | DEPDC7 | S185 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
| Q96QD5 | DEPDC7 | S486 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
| Q99459 | CDC5L | S390 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99816 | TSG101 | S309 | ochoa | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q9BV40 | VAMP8 | S55 | ochoa|psp | Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946). {ECO:0000250|UniProtKB:Q9WUF4, ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:31694946}. |
| Q9BVC5 | C2orf49 | S112 | ochoa | Ashwin | None |
| Q9BX66 | SORBS1 | S697 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXW9 | FANCD2 | S126 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9H0A0 | NAT10 | S67 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
| Q9H4A3 | WNK1 | S1220 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H582 | ZNF644 | S1186 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9HAN9 | NMNAT1 | S117 | ochoa | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (By similarity). {ECO:0000250|UniProtKB:Q9EPA7, ECO:0000269|PubMed:17402747, ECO:0000269|PubMed:27257257}. |
| Q9HC07 | TMEM165 | S221 | ochoa | Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL) | Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity) (PubMed:22683087, PubMed:23569283, PubMed:27008884, PubMed:32047108). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated. {ECO:0000250|UniProtKB:P38301, ECO:0000250|UniProtKB:P52875, ECO:0000269|PubMed:22683087, ECO:0000269|PubMed:23569283, ECO:0000269|PubMed:27008884, ECO:0000269|PubMed:32047108}. |
| Q9HDC5 | JPH1 | S625 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NP61 | ARFGAP3 | S211 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NZJ9 | NUDT4 | S154 | ochoa | Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.61) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4) | Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q8R2U6, ECO:0000269|PubMed:10777568, ECO:0000269|PubMed:12370170}. |
| Q9P260 | RELCH | S419 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P289 | STK26 | S34 | ochoa | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}. |
| Q9P2D0 | IBTK | S1054 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2N5 | RBM27 | S914 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9ULR3 | PPM1H | S112 | ochoa | Protein phosphatase 1H (EC 3.1.3.16) | Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}. |
| Q9UPN3 | MACF1 | S1112 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPN3 | MACF1 | S3929 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y2Q0 | ATP8A1 | S1138 | ochoa | Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity). {ECO:0000250|UniProtKB:P70704, ECO:0000269|PubMed:31416931}. |
| Q9Y4B5 | MTCL1 | S1284 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4J8 | DTNA | S560 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y5B6 | PAXBP1 | S154 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y5U4 | INSIG2 | S151 | psp | Insulin-induced gene 2 protein (INSIG-2) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:17428920, PubMed:26160948, PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767). {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:17428920, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26160948, ECO:0000269|PubMed:32322062}. |
| Q9Y6A5 | TACC3 | S570 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| U3KPZ7 | LOC127814297 | S859 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| V9GY48 | None | S186 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein | None |
| O00506 | STK25 | S30 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| O14757 | CHEK1 | S147 | Sugiyama | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}. |
| Q9BTT0 | ANP32E | S48 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) | Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}. |
| P08758 | ANXA5 | Y91 | Sugiyama | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P43034 | PAFAH1B1 | S157 | Sugiyama | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
| O75582 | RPS6KA5 | S436 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| P05783 | KRT18 | S127 | Sugiyama | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| Q14257 | RCN2 | Y39 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| O75369 | FLNB | Y511 | Sugiyama | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| P12814 | ACTN1 | Y514 | Sugiyama | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P07332 | FES | S485 | Sugiyama | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| O43264 | ZW10 | S611 | Sugiyama | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P16591 | FER | S485 | Sugiyama | Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}. |
| P21802 | FGFR2 | S587 | Sugiyama | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
| Q12824 | SMARCB1 | S111 | Sugiyama | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5) | Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. {ECO:0000250|UniProtKB:Q9Z0H3, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:12226744, ECO:0000269|PubMed:14604992, ECO:0000269|PubMed:16267391, ECO:0000269|PubMed:16314535, ECO:0000269|PubMed:9448295}. |
| Q14008 | CKAP5 | Y317 | Sugiyama | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| P37173 | TGFBR2 | S441 | iPTMNet|EPSD | TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. {ECO:0000269|PubMed:7774578}.; FUNCTION: [Isoform 1]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 2]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 3]: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1. {ECO:0000269|PubMed:34568316}. |
| Q96ES7 | SGF29 | S31 | Sugiyama | SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) | Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity). {ECO:0000250|UniProtKB:Q9DA08, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}. |
| P20042 | EIF2S2 | S160 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P52597 | HNRNPF | S279 | Sugiyama | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| Q13188 | STK3 | S37 | Sugiyama | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q14C86 | GAPVD1 | S746 | Sugiyama | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}. |
| Q15349 | RPS6KA2 | S634 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q12906 | ILF3 | S317 | Sugiyama | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q96PF2 | TSSK2 | S153 | Sugiyama | Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B) | Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}. |
| Q96RG2 | PASK | S996 | Sugiyama | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q9Y6E0 | STK24 | S46 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| Q7L7X3 | TAOK1 | S38 | Sugiyama | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q9UL54 | TAOK2 | S38 | Sugiyama | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 5.814904e-12 | 11.235 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.605547e-08 | 7.794 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.605547e-08 | 7.794 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.184443e-08 | 7.926 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.605547e-08 | 7.794 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.209163e-08 | 7.376 |
| R-HSA-114452 | Activation of BH3-only proteins | 7.132104e-08 | 7.147 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.566477e-07 | 6.805 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.332347e-07 | 6.198 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.626324e-06 | 5.789 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.213566e-06 | 5.655 |
| R-HSA-109581 | Apoptosis | 2.695085e-06 | 5.569 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.650344e-06 | 5.438 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.050694e-06 | 5.297 |
| R-HSA-69481 | G2/M Checkpoints | 8.366869e-06 | 5.077 |
| R-HSA-1640170 | Cell Cycle | 2.133191e-05 | 4.671 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 2.473775e-05 | 4.607 |
| R-HSA-5357801 | Programmed Cell Death | 2.790534e-05 | 4.554 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 3.536679e-05 | 4.451 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 4.253250e-05 | 4.371 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.503900e-05 | 4.346 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 8.155652e-05 | 4.089 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 9.671161e-05 | 4.015 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.291746e-04 | 3.889 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 1.482426e-04 | 3.829 |
| R-HSA-3371556 | Cellular response to heat stress | 1.704578e-04 | 3.768 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.943071e-04 | 3.712 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.092051e-04 | 3.679 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.468292e-04 | 3.608 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.417670e-04 | 3.617 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.885493e-04 | 3.540 |
| R-HSA-2028269 | Signaling by Hippo | 3.145715e-04 | 3.502 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 3.716122e-04 | 3.430 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.887323e-04 | 3.410 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.946061e-04 | 3.404 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.486098e-04 | 3.458 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.664131e-04 | 3.436 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.849852e-04 | 3.233 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.791401e-04 | 3.237 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.802921e-04 | 3.236 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.301856e-04 | 3.276 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.331158e-04 | 3.273 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.932989e-04 | 3.227 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.439275e-04 | 3.191 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 6.439275e-04 | 3.191 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 7.391395e-04 | 3.131 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 7.205026e-04 | 3.142 |
| R-HSA-68886 | M Phase | 8.175338e-04 | 3.087 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.248857e-04 | 3.084 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.589702e-04 | 3.018 |
| R-HSA-190377 | FGFR2b ligand binding and activation | 1.149274e-03 | 2.940 |
| R-HSA-68877 | Mitotic Prometaphase | 1.106340e-03 | 2.956 |
| R-HSA-162587 | HIV Life Cycle | 1.080172e-03 | 2.967 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.078389e-03 | 2.967 |
| R-HSA-75153 | Apoptotic execution phase | 1.189342e-03 | 2.925 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.213495e-03 | 2.916 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.743504e-03 | 2.759 |
| R-HSA-199991 | Membrane Trafficking | 1.729464e-03 | 2.762 |
| R-HSA-109704 | PI3K Cascade | 1.623713e-03 | 2.789 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.737210e-03 | 2.760 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.853396e-03 | 2.732 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.929922e-03 | 2.714 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 1.993861e-03 | 2.700 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.129697e-03 | 2.672 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.129697e-03 | 2.672 |
| R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 2.442914e-03 | 2.612 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.571216e-03 | 2.590 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.571216e-03 | 2.590 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.813897e-03 | 2.551 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.566089e-03 | 2.591 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.566089e-03 | 2.591 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.813897e-03 | 2.551 |
| R-HSA-112399 | IRS-mediated signalling | 2.648843e-03 | 2.577 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.071808e-03 | 2.513 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.222992e-03 | 2.492 |
| R-HSA-162906 | HIV Infection | 3.320051e-03 | 2.479 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.345403e-03 | 2.476 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.410686e-03 | 2.467 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.845493e-03 | 2.415 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.845493e-03 | 2.415 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.639852e-03 | 2.439 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.941435e-03 | 2.404 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.077156e-03 | 2.390 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.077156e-03 | 2.390 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.318625e-03 | 2.365 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.407202e-03 | 2.356 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.570124e-03 | 2.340 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.605499e-03 | 2.337 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.964107e-03 | 2.304 |
| R-HSA-392517 | Rap1 signalling | 5.213715e-03 | 2.283 |
| R-HSA-190236 | Signaling by FGFR | 5.234317e-03 | 2.281 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.702985e-03 | 2.244 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 6.079782e-03 | 2.216 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.340985e-03 | 2.272 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.629971e-03 | 2.178 |
| R-HSA-380287 | Centrosome maturation | 7.321227e-03 | 2.135 |
| R-HSA-199920 | CREB phosphorylation | 7.622823e-03 | 2.118 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 7.513266e-03 | 2.124 |
| R-HSA-68882 | Mitotic Anaphase | 7.594397e-03 | 2.120 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.321227e-03 | 2.135 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.018612e-03 | 2.154 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.590902e-03 | 2.120 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 7.794133e-03 | 2.108 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 8.007947e-03 | 2.096 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 8.516848e-03 | 2.070 |
| R-HSA-1483249 | Inositol phosphate metabolism | 9.526774e-03 | 2.021 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.013533e-02 | 1.994 |
| R-HSA-74160 | Gene expression (Transcription) | 1.097770e-02 | 1.959 |
| R-HSA-525793 | Myogenesis | 1.137040e-02 | 1.944 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.317621e-02 | 1.880 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.243353e-02 | 1.905 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.317621e-02 | 1.880 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.105871e-02 | 1.956 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.117574e-02 | 1.952 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.117574e-02 | 1.952 |
| R-HSA-449147 | Signaling by Interleukins | 1.256533e-02 | 1.901 |
| R-HSA-68875 | Mitotic Prophase | 1.350946e-02 | 1.869 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.361468e-02 | 1.866 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.473979e-02 | 1.832 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.645651e-02 | 1.784 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.782099e-02 | 1.749 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.689922e-02 | 1.772 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.645651e-02 | 1.784 |
| R-HSA-191859 | snRNP Assembly | 1.645651e-02 | 1.784 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.811121e-02 | 1.742 |
| R-HSA-450294 | MAP kinase activation | 1.811121e-02 | 1.742 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.685905e-02 | 1.773 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.797999e-02 | 1.745 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.538734e-02 | 1.813 |
| R-HSA-74752 | Signaling by Insulin receptor | 1.654170e-02 | 1.781 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.001940e-02 | 1.699 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.204613e-02 | 1.657 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.256654e-02 | 1.647 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.295021e-02 | 1.639 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.318128e-02 | 1.635 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.326114e-02 | 1.633 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.368067e-02 | 1.626 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.462180e-02 | 1.609 |
| R-HSA-170968 | Frs2-mediated activation | 2.523970e-02 | 1.598 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 2.523970e-02 | 1.598 |
| R-HSA-448424 | Interleukin-17 signaling | 2.681392e-02 | 1.572 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.764471e-02 | 1.558 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.828438e-02 | 1.548 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.828438e-02 | 1.548 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.828438e-02 | 1.548 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.828438e-02 | 1.548 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.828438e-02 | 1.548 |
| R-HSA-3642279 | TGFBR2 MSI Frameshift Mutants in Cancer | 2.828438e-02 | 1.548 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.828438e-02 | 1.548 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.828438e-02 | 1.548 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.903421e-02 | 1.537 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.903421e-02 | 1.537 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.922693e-02 | 1.534 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.922693e-02 | 1.534 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.993065e-02 | 1.524 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.018409e-02 | 1.520 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.094787e-02 | 1.509 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.094787e-02 | 1.509 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 4.212642e-02 | 1.375 |
| R-HSA-8853333 | Signaling by FGFR2 fusions | 4.212642e-02 | 1.375 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 4.212642e-02 | 1.375 |
| R-HSA-9664420 | Killing mechanisms | 3.397501e-02 | 1.469 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 3.397501e-02 | 1.469 |
| R-HSA-169893 | Prolonged ERK activation events | 3.397501e-02 | 1.469 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.711240e-02 | 1.430 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.898135e-02 | 1.409 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 4.212642e-02 | 1.375 |
| R-HSA-8953854 | Metabolism of RNA | 4.058451e-02 | 1.392 |
| R-HSA-913531 | Interferon Signaling | 3.284323e-02 | 1.484 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 3.711240e-02 | 1.430 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.314020e-02 | 1.480 |
| R-HSA-166520 | Signaling by NTRKs | 3.375980e-02 | 1.472 |
| R-HSA-70326 | Glucose metabolism | 4.172587e-02 | 1.380 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.783968e-02 | 1.422 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 4.370312e-02 | 1.359 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 4.370312e-02 | 1.359 |
| R-HSA-212436 | Generic Transcription Pathway | 4.397658e-02 | 1.357 |
| R-HSA-437239 | Recycling pathway of L1 | 4.555849e-02 | 1.341 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.881848e-02 | 1.311 |
| R-HSA-194138 | Signaling by VEGF | 5.261582e-02 | 1.279 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 5.432565e-02 | 1.265 |
| R-HSA-198753 | ERK/MAPK targets | 5.432565e-02 | 1.265 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 5.577212e-02 | 1.254 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 5.577212e-02 | 1.254 |
| R-HSA-5357609 | Glycogen storage disease type II (GAA) | 5.577212e-02 | 1.254 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 5.577212e-02 | 1.254 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 5.577212e-02 | 1.254 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 5.577212e-02 | 1.254 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.922425e-02 | 1.160 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 6.922425e-02 | 1.160 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 8.248556e-02 | 1.084 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 8.248556e-02 | 1.084 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 7.789235e-02 | 1.109 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 8.208484e-02 | 1.086 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.946789e-02 | 1.158 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 5.577212e-02 | 1.254 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 6.922425e-02 | 1.160 |
| R-HSA-139910 | Activation of BMF and translocation to mitochondria | 6.922425e-02 | 1.160 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.356215e-02 | 1.197 |
| R-HSA-205025 | NADE modulates death signalling | 8.248556e-02 | 1.084 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 6.575067e-02 | 1.182 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.847127e-02 | 1.233 |
| R-HSA-5617833 | Cilium Assembly | 8.241169e-02 | 1.084 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 5.577212e-02 | 1.254 |
| R-HSA-9007892 | Interleukin-38 signaling | 8.248556e-02 | 1.084 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.105204e-02 | 1.091 |
| R-HSA-9830364 | Formation of the nephric duct | 7.377055e-02 | 1.132 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 5.804918e-02 | 1.236 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.322808e-02 | 1.135 |
| R-HSA-162582 | Signal Transduction | 7.304235e-02 | 1.136 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.322808e-02 | 1.135 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.322808e-02 | 1.135 |
| R-HSA-3000170 | Syndecan interactions | 6.575067e-02 | 1.182 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 6.575067e-02 | 1.182 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.931760e-02 | 1.227 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.608872e-02 | 1.119 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 6.972233e-02 | 1.157 |
| R-HSA-8863678 | Neurodegenerative Diseases | 6.972233e-02 | 1.157 |
| R-HSA-70171 | Glycolysis | 7.708986e-02 | 1.113 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.220029e-02 | 1.085 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 8.208484e-02 | 1.086 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.569486e-02 | 1.121 |
| R-HSA-186797 | Signaling by PDGF | 8.066692e-02 | 1.093 |
| R-HSA-72306 | tRNA processing | 5.654301e-02 | 1.248 |
| R-HSA-9679506 | SARS-CoV Infections | 7.358262e-02 | 1.133 |
| R-HSA-373755 | Semaphorin interactions | 8.332970e-02 | 1.079 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 8.332970e-02 | 1.079 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.387179e-02 | 1.076 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.511333e-02 | 1.070 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 8.927235e-02 | 1.049 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 9.067063e-02 | 1.043 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 9.067063e-02 | 1.043 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.352763e-02 | 1.029 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.352763e-02 | 1.029 |
| R-HSA-211000 | Gene Silencing by RNA | 9.352763e-02 | 1.029 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 9.434931e-02 | 1.025 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 9.555873e-02 | 1.020 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 9.555873e-02 | 1.020 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 9.555873e-02 | 1.020 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 9.555873e-02 | 1.020 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 9.569089e-02 | 1.019 |
| R-HSA-167172 | Transcription of the HIV genome | 9.719355e-02 | 1.012 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.745503e-02 | 1.011 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 9.787764e-02 | 1.009 |
| R-HSA-186763 | Downstream signal transduction | 9.950607e-02 | 1.002 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.000877e-01 | 1.000 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.000877e-01 | 1.000 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.053057e-01 | 0.978 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.068553e-01 | 0.971 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.084464e-01 | 0.965 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.084464e-01 | 0.965 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 1.084464e-01 | 0.965 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 1.084464e-01 | 0.965 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.084464e-01 | 0.965 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.084464e-01 | 0.965 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 1.084464e-01 | 0.965 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.085703e-01 | 0.964 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.085703e-01 | 0.964 |
| R-HSA-9610379 | HCMV Late Events | 1.091189e-01 | 0.962 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.336758e-01 | 0.874 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.336758e-01 | 0.874 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.336758e-01 | 0.874 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.336758e-01 | 0.874 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.336758e-01 | 0.874 |
| R-HSA-444257 | RSK activation | 1.460226e-01 | 0.836 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.460226e-01 | 0.836 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 1.460226e-01 | 0.836 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.460226e-01 | 0.836 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.460226e-01 | 0.836 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.581943e-01 | 0.801 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.701931e-01 | 0.769 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.701931e-01 | 0.769 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.820217e-01 | 0.740 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.936824e-01 | 0.713 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.936824e-01 | 0.713 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.051776e-01 | 0.688 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.051776e-01 | 0.688 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.051776e-01 | 0.688 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.051776e-01 | 0.688 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.051776e-01 | 0.688 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.178435e-01 | 0.929 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.467317e-01 | 0.833 |
| R-HSA-167161 | HIV Transcription Initiation | 1.566600e-01 | 0.805 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.566600e-01 | 0.805 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.616711e-01 | 0.791 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.768703e-01 | 0.752 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.701931e-01 | 0.769 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.321038e-01 | 0.879 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.178435e-01 | 0.929 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.211513e-01 | 0.917 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.051776e-01 | 0.688 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.667111e-01 | 0.778 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.183165e-01 | 0.661 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.371030e-01 | 0.863 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 2.165096e-01 | 0.665 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.566600e-01 | 0.805 |
| R-HSA-1221632 | Meiotic synapsis | 2.183165e-01 | 0.661 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.149651e-01 | 0.939 |
| R-HSA-69541 | Stabilization of p53 | 1.418184e-01 | 0.848 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 1.336758e-01 | 0.874 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 1.820217e-01 | 0.740 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 1.936824e-01 | 0.713 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.936824e-01 | 0.713 |
| R-HSA-190322 | FGFR4 ligand binding and activation | 2.165096e-01 | 0.665 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.165096e-01 | 0.665 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.178435e-01 | 0.929 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.273067e-01 | 0.895 |
| R-HSA-9766229 | Degradation of CDH1 | 1.974572e-01 | 0.705 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.225525e-01 | 0.912 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.571336e-01 | 0.804 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.131820e-01 | 0.946 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.701931e-01 | 0.769 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.701931e-01 | 0.769 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.768703e-01 | 0.752 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.768703e-01 | 0.752 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.974572e-01 | 0.705 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.974572e-01 | 0.705 |
| R-HSA-170984 | ARMS-mediated activation | 1.581943e-01 | 0.801 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 2.165096e-01 | 0.665 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.467317e-01 | 0.833 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.186242e-01 | 0.926 |
| R-HSA-187687 | Signalling to ERKs | 1.225525e-01 | 0.912 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.922811e-01 | 0.716 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.581943e-01 | 0.801 |
| R-HSA-3371511 | HSF1 activation | 1.273067e-01 | 0.895 |
| R-HSA-165159 | MTOR signalling | 1.616711e-01 | 0.791 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.788698e-01 | 0.747 |
| R-HSA-381042 | PERK regulates gene expression | 1.225525e-01 | 0.912 |
| R-HSA-114608 | Platelet degranulation | 1.488297e-01 | 0.827 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.768703e-01 | 0.752 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.819860e-01 | 0.740 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.032319e-01 | 0.692 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.165096e-01 | 0.665 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.677143e-01 | 0.775 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.180393e-01 | 0.928 |
| R-HSA-9675135 | Diseases of DNA repair | 1.819860e-01 | 0.740 |
| R-HSA-164944 | Nef and signal transduction | 1.211513e-01 | 0.917 |
| R-HSA-8964011 | HDL clearance | 1.211513e-01 | 0.917 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.581943e-01 | 0.801 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 2.165096e-01 | 0.665 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.149651e-01 | 0.939 |
| R-HSA-73894 | DNA Repair | 1.822573e-01 | 0.739 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.581943e-01 | 0.801 |
| R-HSA-373760 | L1CAM interactions | 1.185802e-01 | 0.926 |
| R-HSA-69275 | G2/M Transition | 1.737595e-01 | 0.760 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.516795e-01 | 0.819 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.785148e-01 | 0.748 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.258722e-01 | 0.900 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.258722e-01 | 0.900 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.333491e-01 | 0.875 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.333491e-01 | 0.875 |
| R-HSA-168255 | Influenza Infection | 1.575188e-01 | 0.803 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.138248e-01 | 0.944 |
| R-HSA-2559583 | Cellular Senescence | 1.597993e-01 | 0.796 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.225525e-01 | 0.912 |
| R-HSA-9833482 | PKR-mediated signaling | 1.338551e-01 | 0.873 |
| R-HSA-9824446 | Viral Infection Pathways | 2.146534e-01 | 0.668 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.161918e-01 | 0.935 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.167060e-01 | 0.664 |
| R-HSA-2262752 | Cellular responses to stress | 1.120942e-01 | 0.950 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.616711e-01 | 0.791 |
| R-HSA-8983711 | OAS antiviral response | 2.051776e-01 | 0.688 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.178435e-01 | 0.929 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 1.369418e-01 | 0.863 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.922811e-01 | 0.716 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.820217e-01 | 0.740 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.130814e-01 | 0.671 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.780007e-01 | 0.750 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.694581e-01 | 0.771 |
| R-HSA-5619102 | SLC transporter disorders | 1.291665e-01 | 0.889 |
| R-HSA-9758941 | Gastrulation | 2.197047e-01 | 0.658 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.227146e-01 | 0.652 |
| R-HSA-72649 | Translation initiation complex formation | 2.235626e-01 | 0.651 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 2.276807e-01 | 0.643 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.276807e-01 | 0.643 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.276807e-01 | 0.643 |
| R-HSA-418457 | cGMP effects | 2.276807e-01 | 0.643 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 2.276807e-01 | 0.643 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.276807e-01 | 0.643 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.276807e-01 | 0.643 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.276807e-01 | 0.643 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.288185e-01 | 0.641 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.292293e-01 | 0.640 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.340828e-01 | 0.631 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.386932e-01 | 0.622 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.386932e-01 | 0.622 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 2.386932e-01 | 0.622 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.386932e-01 | 0.622 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.386932e-01 | 0.622 |
| R-HSA-9857492 | Protein lipoylation | 2.386932e-01 | 0.622 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.386932e-01 | 0.622 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 2.386932e-01 | 0.622 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.386932e-01 | 0.622 |
| R-HSA-416700 | Other semaphorin interactions | 2.386932e-01 | 0.622 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.393542e-01 | 0.621 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.393542e-01 | 0.621 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.446314e-01 | 0.611 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.481632e-01 | 0.605 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.481632e-01 | 0.605 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.485240e-01 | 0.605 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.495493e-01 | 0.603 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.495493e-01 | 0.603 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.495493e-01 | 0.603 |
| R-HSA-446728 | Cell junction organization | 2.580349e-01 | 0.588 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.602514e-01 | 0.585 |
| R-HSA-6783984 | Glycine degradation | 2.602514e-01 | 0.585 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.604859e-01 | 0.584 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.651354e-01 | 0.577 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 2.657745e-01 | 0.575 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.708014e-01 | 0.567 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 2.708014e-01 | 0.567 |
| R-HSA-3229121 | Glycogen storage diseases | 2.708014e-01 | 0.567 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.708014e-01 | 0.567 |
| R-HSA-8848021 | Signaling by PTK6 | 2.710631e-01 | 0.567 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.710631e-01 | 0.567 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.711807e-01 | 0.567 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.711807e-01 | 0.567 |
| R-HSA-168256 | Immune System | 2.713274e-01 | 0.567 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.761394e-01 | 0.559 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.763507e-01 | 0.559 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 2.812016e-01 | 0.551 |
| R-HSA-3928664 | Ephrin signaling | 2.812016e-01 | 0.551 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 2.812016e-01 | 0.551 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.816362e-01 | 0.550 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.846681e-01 | 0.546 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.866560e-01 | 0.543 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.866560e-01 | 0.543 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.905367e-01 | 0.537 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.914541e-01 | 0.535 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.914541e-01 | 0.535 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.914541e-01 | 0.535 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.914541e-01 | 0.535 |
| R-HSA-9834899 | Specification of the neural plate border | 2.914541e-01 | 0.535 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.914541e-01 | 0.535 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.914541e-01 | 0.535 |
| R-HSA-9830369 | Kidney development | 2.921968e-01 | 0.534 |
| R-HSA-5693538 | Homology Directed Repair | 2.944213e-01 | 0.531 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.013807e-01 | 0.521 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.015610e-01 | 0.521 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.015610e-01 | 0.521 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.015610e-01 | 0.521 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.015610e-01 | 0.521 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.015610e-01 | 0.521 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.015610e-01 | 0.521 |
| R-HSA-3322077 | Glycogen synthesis | 3.015610e-01 | 0.521 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.015610e-01 | 0.521 |
| R-HSA-9823730 | Formation of definitive endoderm | 3.015610e-01 | 0.521 |
| R-HSA-373753 | Nephrin family interactions | 3.015610e-01 | 0.521 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.019254e-01 | 0.520 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.027374e-01 | 0.519 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 3.115244e-01 | 0.507 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.115244e-01 | 0.507 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.184947e-01 | 0.497 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.184947e-01 | 0.497 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.184947e-01 | 0.497 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 3.213462e-01 | 0.493 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 3.213462e-01 | 0.493 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.213462e-01 | 0.493 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.213462e-01 | 0.493 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.213462e-01 | 0.493 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 3.213462e-01 | 0.493 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.213462e-01 | 0.493 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.237295e-01 | 0.490 |
| R-HSA-4086398 | Ca2+ pathway | 3.237295e-01 | 0.490 |
| R-HSA-1643685 | Disease | 3.243063e-01 | 0.489 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 3.310286e-01 | 0.480 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.310286e-01 | 0.480 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.310286e-01 | 0.480 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.310286e-01 | 0.480 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.310286e-01 | 0.480 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.310286e-01 | 0.480 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.310286e-01 | 0.480 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.310286e-01 | 0.480 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.377396e-01 | 0.471 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.405733e-01 | 0.468 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.405733e-01 | 0.468 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.405733e-01 | 0.468 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 3.405733e-01 | 0.468 |
| R-HSA-8854691 | Interleukin-20 family signaling | 3.405733e-01 | 0.468 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.405733e-01 | 0.468 |
| R-HSA-4839726 | Chromatin organization | 3.433721e-01 | 0.464 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.458757e-01 | 0.461 |
| R-HSA-9609646 | HCMV Infection | 3.461910e-01 | 0.461 |
| R-HSA-4086400 | PCP/CE pathway | 3.497356e-01 | 0.456 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 3.499825e-01 | 0.456 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.499825e-01 | 0.456 |
| R-HSA-9865881 | Complex III assembly | 3.499825e-01 | 0.456 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.499825e-01 | 0.456 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.499825e-01 | 0.456 |
| R-HSA-1500931 | Cell-Cell communication | 3.521445e-01 | 0.453 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.555798e-01 | 0.449 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 3.592580e-01 | 0.445 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.592580e-01 | 0.445 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.592580e-01 | 0.445 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.592580e-01 | 0.445 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.592580e-01 | 0.445 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.592580e-01 | 0.445 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.592580e-01 | 0.445 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.592580e-01 | 0.445 |
| R-HSA-3214842 | HDMs demethylate histones | 3.592580e-01 | 0.445 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.651794e-01 | 0.437 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.652841e-01 | 0.437 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.684017e-01 | 0.434 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.717507e-01 | 0.430 |
| R-HSA-9609690 | HCMV Early Events | 3.717507e-01 | 0.430 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.774154e-01 | 0.423 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.774154e-01 | 0.423 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.774154e-01 | 0.423 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 3.774154e-01 | 0.423 |
| R-HSA-6798695 | Neutrophil degranulation | 3.796522e-01 | 0.421 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.829192e-01 | 0.417 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.855488e-01 | 0.414 |
| R-HSA-1500620 | Meiosis | 3.855488e-01 | 0.414 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.855488e-01 | 0.414 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.863011e-01 | 0.413 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.863011e-01 | 0.413 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.863011e-01 | 0.413 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.863011e-01 | 0.413 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.863011e-01 | 0.413 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 3.863011e-01 | 0.413 |
| R-HSA-1266738 | Developmental Biology | 3.903481e-01 | 0.409 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.905977e-01 | 0.408 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.950605e-01 | 0.403 |
| R-HSA-72086 | mRNA Capping | 3.950605e-01 | 0.403 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.950605e-01 | 0.403 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.950605e-01 | 0.403 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.950605e-01 | 0.403 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.950605e-01 | 0.403 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.950605e-01 | 0.403 |
| R-HSA-180024 | DARPP-32 events | 3.950605e-01 | 0.403 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.956280e-01 | 0.403 |
| R-HSA-72172 | mRNA Splicing | 4.007730e-01 | 0.397 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.036954e-01 | 0.394 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.036954e-01 | 0.394 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.036954e-01 | 0.394 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.056313e-01 | 0.392 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.106033e-01 | 0.387 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.122076e-01 | 0.385 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.122076e-01 | 0.385 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.122076e-01 | 0.385 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.122076e-01 | 0.385 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.122076e-01 | 0.385 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.205987e-01 | 0.376 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.205987e-01 | 0.376 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.205987e-01 | 0.376 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.205987e-01 | 0.376 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.221287e-01 | 0.375 |
| R-HSA-422475 | Axon guidance | 4.243941e-01 | 0.372 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.288706e-01 | 0.368 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.288706e-01 | 0.368 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.288706e-01 | 0.368 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.288706e-01 | 0.368 |
| R-HSA-9930044 | Nuclear RNA decay | 4.288706e-01 | 0.368 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.288706e-01 | 0.368 |
| R-HSA-354192 | Integrin signaling | 4.288706e-01 | 0.368 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.288706e-01 | 0.368 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.288706e-01 | 0.368 |
| R-HSA-9733709 | Cardiogenesis | 4.288706e-01 | 0.368 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.370250e-01 | 0.359 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 4.370250e-01 | 0.359 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.409662e-01 | 0.356 |
| R-HSA-5673000 | RAF activation | 4.450633e-01 | 0.352 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.450633e-01 | 0.352 |
| R-HSA-418990 | Adherens junctions interactions | 4.454047e-01 | 0.351 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.529874e-01 | 0.344 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 4.529874e-01 | 0.344 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.529874e-01 | 0.344 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.543868e-01 | 0.343 |
| R-HSA-9612973 | Autophagy | 4.558663e-01 | 0.341 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.591377e-01 | 0.338 |
| R-HSA-4641258 | Degradation of DVL | 4.684992e-01 | 0.329 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.684992e-01 | 0.329 |
| R-HSA-419037 | NCAM1 interactions | 4.684992e-01 | 0.329 |
| R-HSA-8948216 | Collagen chain trimerization | 4.684992e-01 | 0.329 |
| R-HSA-3214847 | HATs acetylate histones | 4.685674e-01 | 0.329 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.685674e-01 | 0.329 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.705993e-01 | 0.327 |
| R-HSA-8875878 | MET promotes cell motility | 4.760901e-01 | 0.322 |
| R-HSA-195721 | Signaling by WNT | 4.806320e-01 | 0.318 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.835730e-01 | 0.316 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.835730e-01 | 0.316 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.835730e-01 | 0.316 |
| R-HSA-72312 | rRNA processing | 4.889900e-01 | 0.311 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.909495e-01 | 0.309 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.909495e-01 | 0.309 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.909495e-01 | 0.309 |
| R-HSA-167169 | HIV Transcription Elongation | 4.909495e-01 | 0.309 |
| R-HSA-3371568 | Attenuation phase | 4.909495e-01 | 0.309 |
| R-HSA-8982491 | Glycogen metabolism | 4.909495e-01 | 0.309 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.909495e-01 | 0.309 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.917082e-01 | 0.308 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.982211e-01 | 0.303 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.982211e-01 | 0.303 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.982211e-01 | 0.303 |
| R-HSA-9675108 | Nervous system development | 4.991279e-01 | 0.302 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 5.053892e-01 | 0.296 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.053892e-01 | 0.296 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.053892e-01 | 0.296 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.053892e-01 | 0.296 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.053892e-01 | 0.296 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.101490e-01 | 0.292 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.124554e-01 | 0.290 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.124554e-01 | 0.290 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.142073e-01 | 0.289 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.142073e-01 | 0.289 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.194211e-01 | 0.284 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.194211e-01 | 0.284 |
| R-HSA-8854214 | TBC/RABGAPs | 5.194211e-01 | 0.284 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.206671e-01 | 0.283 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.206671e-01 | 0.283 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.262876e-01 | 0.279 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.317294e-01 | 0.274 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.330565e-01 | 0.273 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.330565e-01 | 0.273 |
| R-HSA-9824272 | Somitogenesis | 5.330565e-01 | 0.273 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.330565e-01 | 0.273 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.397291e-01 | 0.268 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.397291e-01 | 0.268 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.397291e-01 | 0.268 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.397291e-01 | 0.268 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.397291e-01 | 0.268 |
| R-HSA-421270 | Cell-cell junction organization | 5.457680e-01 | 0.263 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.463067e-01 | 0.263 |
| R-HSA-70263 | Gluconeogenesis | 5.527907e-01 | 0.257 |
| R-HSA-425410 | Metal ion SLC transporters | 5.527907e-01 | 0.257 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.548217e-01 | 0.256 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.591825e-01 | 0.252 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 5.591825e-01 | 0.252 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.613458e-01 | 0.251 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.716944e-01 | 0.243 |
| R-HSA-912446 | Meiotic recombination | 5.716944e-01 | 0.243 |
| R-HSA-983712 | Ion channel transport | 5.746098e-01 | 0.241 |
| R-HSA-72187 | mRNA 3'-end processing | 5.778171e-01 | 0.238 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.778171e-01 | 0.238 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.778171e-01 | 0.238 |
| R-HSA-5663205 | Infectious disease | 5.788898e-01 | 0.237 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.838527e-01 | 0.234 |
| R-HSA-6809371 | Formation of the cornified envelope | 5.896055e-01 | 0.229 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.956673e-01 | 0.225 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.956673e-01 | 0.225 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.014487e-01 | 0.221 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.014487e-01 | 0.221 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.014487e-01 | 0.221 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.014487e-01 | 0.221 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.127658e-01 | 0.213 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.155657e-01 | 0.211 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.183038e-01 | 0.209 |
| R-HSA-186712 | Regulation of beta-cell development | 6.183038e-01 | 0.209 |
| R-HSA-1474165 | Reproduction | 6.202262e-01 | 0.207 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.237629e-01 | 0.205 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.237629e-01 | 0.205 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.237629e-01 | 0.205 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.237629e-01 | 0.205 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.237629e-01 | 0.205 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.237629e-01 | 0.205 |
| R-HSA-983189 | Kinesins | 6.237629e-01 | 0.205 |
| R-HSA-379724 | tRNA Aminoacylation | 6.237629e-01 | 0.205 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.291443e-01 | 0.201 |
| R-HSA-1442490 | Collagen degradation | 6.291443e-01 | 0.201 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.396782e-01 | 0.194 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.455565e-01 | 0.190 |
| R-HSA-397014 | Muscle contraction | 6.480948e-01 | 0.188 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.549231e-01 | 0.184 |
| R-HSA-196807 | Nicotinate metabolism | 6.598606e-01 | 0.181 |
| R-HSA-1632852 | Macroautophagy | 6.628223e-01 | 0.179 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.628223e-01 | 0.179 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.647278e-01 | 0.177 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.647278e-01 | 0.177 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.742551e-01 | 0.171 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.742551e-01 | 0.171 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.742551e-01 | 0.171 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.789171e-01 | 0.168 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.789171e-01 | 0.168 |
| R-HSA-3000178 | ECM proteoglycans | 6.789171e-01 | 0.168 |
| R-HSA-9638482 | Metal ion assimilation from the host | 6.789171e-01 | 0.168 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.805045e-01 | 0.167 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.866157e-01 | 0.163 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 6.880429e-01 | 0.162 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.898930e-01 | 0.161 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.953263e-01 | 0.158 |
| R-HSA-917937 | Iron uptake and transport | 6.969104e-01 | 0.157 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.012496e-01 | 0.154 |
| R-HSA-5689603 | UCH proteinases | 7.012496e-01 | 0.154 |
| R-HSA-73887 | Death Receptor Signaling | 7.075874e-01 | 0.150 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.075874e-01 | 0.150 |
| R-HSA-216083 | Integrin cell surface interactions | 7.097432e-01 | 0.149 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 7.097432e-01 | 0.149 |
| R-HSA-1989781 | PPARA activates gene expression | 7.105879e-01 | 0.148 |
| R-HSA-9659379 | Sensory processing of sound | 7.138994e-01 | 0.146 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.138994e-01 | 0.146 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.165120e-01 | 0.145 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.179964e-01 | 0.144 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.179964e-01 | 0.144 |
| R-HSA-6806834 | Signaling by MET | 7.179964e-01 | 0.144 |
| R-HSA-9711097 | Cellular response to starvation | 7.194358e-01 | 0.143 |
| R-HSA-157118 | Signaling by NOTCH | 7.219139e-01 | 0.142 |
| R-HSA-109582 | Hemostasis | 7.222415e-01 | 0.141 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.260159e-01 | 0.139 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.266134e-01 | 0.139 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.376213e-01 | 0.132 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.413800e-01 | 0.130 |
| R-HSA-1474244 | Extracellular matrix organization | 7.429745e-01 | 0.129 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.487372e-01 | 0.126 |
| R-HSA-156902 | Peptide chain elongation | 7.523373e-01 | 0.124 |
| R-HSA-5688426 | Deubiquitination | 7.562332e-01 | 0.121 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.603276e-01 | 0.119 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.628324e-01 | 0.118 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.628324e-01 | 0.118 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.653734e-01 | 0.116 |
| R-HSA-1280218 | Adaptive Immune System | 7.658032e-01 | 0.116 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.662313e-01 | 0.116 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.678617e-01 | 0.115 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.695818e-01 | 0.114 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.695818e-01 | 0.114 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.695818e-01 | 0.114 |
| R-HSA-1474290 | Collagen formation | 7.761400e-01 | 0.110 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.793491e-01 | 0.108 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.825123e-01 | 0.107 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.825123e-01 | 0.107 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.825123e-01 | 0.107 |
| R-HSA-157579 | Telomere Maintenance | 7.887040e-01 | 0.103 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.976639e-01 | 0.098 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.005657e-01 | 0.097 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.034261e-01 | 0.095 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.034261e-01 | 0.095 |
| R-HSA-192823 | Viral mRNA Translation | 8.062455e-01 | 0.094 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.067795e-01 | 0.093 |
| R-HSA-9658195 | Leishmania infection | 8.075887e-01 | 0.093 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.075887e-01 | 0.093 |
| R-HSA-111885 | Opioid Signalling | 8.090248e-01 | 0.092 |
| R-HSA-9833110 | RSV-host interactions | 8.117643e-01 | 0.091 |
| R-HSA-418346 | Platelet homeostasis | 8.171265e-01 | 0.088 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.197503e-01 | 0.086 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.223366e-01 | 0.085 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.230102e-01 | 0.085 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.287757e-01 | 0.082 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.323175e-01 | 0.080 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.323175e-01 | 0.080 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.347243e-01 | 0.078 |
| R-HSA-6805567 | Keratinization | 8.362008e-01 | 0.078 |
| R-HSA-909733 | Interferon alpha/beta signaling | 8.440121e-01 | 0.074 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.467955e-01 | 0.072 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.484592e-01 | 0.071 |
| R-HSA-73886 | Chromosome Maintenance | 8.569783e-01 | 0.067 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.610573e-01 | 0.065 |
| R-HSA-8951664 | Neddylation | 8.615271e-01 | 0.065 |
| R-HSA-168249 | Innate Immune System | 8.789121e-01 | 0.056 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.815068e-01 | 0.055 |
| R-HSA-8939211 | ESR-mediated signaling | 8.845634e-01 | 0.053 |
| R-HSA-72766 | Translation | 8.884625e-01 | 0.051 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.913675e-01 | 0.050 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.929296e-01 | 0.049 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.959871e-01 | 0.048 |
| R-HSA-9664407 | Parasite infection | 8.959871e-01 | 0.048 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.959871e-01 | 0.048 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.073107e-01 | 0.042 |
| R-HSA-69242 | S Phase | 9.087046e-01 | 0.042 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.125897e-01 | 0.040 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.138478e-01 | 0.039 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.138478e-01 | 0.039 |
| R-HSA-382551 | Transport of small molecules | 9.141404e-01 | 0.039 |
| R-HSA-112316 | Neuronal System | 9.221631e-01 | 0.035 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.276098e-01 | 0.033 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.317239e-01 | 0.031 |
| R-HSA-418555 | G alpha (s) signalling events | 9.355449e-01 | 0.029 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.355449e-01 | 0.029 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.373894e-01 | 0.028 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.401854e-01 | 0.027 |
| R-HSA-611105 | Respiratory electron transport | 9.417740e-01 | 0.026 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.542156e-01 | 0.020 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.582985e-01 | 0.018 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.595132e-01 | 0.018 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.595132e-01 | 0.018 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.595132e-01 | 0.018 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.730674e-01 | 0.012 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.745051e-01 | 0.011 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.820351e-01 | 0.008 |
| R-HSA-416476 | G alpha (q) signalling events | 9.835984e-01 | 0.007 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.845291e-01 | 0.007 |
| R-HSA-1483257 | Phospholipid metabolism | 9.895745e-01 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 9.931821e-01 | 0.003 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.946866e-01 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.962096e-01 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 9.964557e-01 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 9.980163e-01 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 9.985230e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.990860e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.997222e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.998917e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.999660e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999997e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.884 | 0.229 | 2 | 0.872 |
CLK3 |
0.870 | 0.186 | 1 | 0.858 |
DSTYK |
0.868 | 0.130 | 2 | 0.887 |
MOS |
0.866 | 0.126 | 1 | 0.908 |
CDC7 |
0.865 | 0.036 | 1 | 0.889 |
NDR2 |
0.865 | 0.077 | -3 | 0.810 |
GCN2 |
0.865 | -0.025 | 2 | 0.808 |
PIM3 |
0.864 | 0.074 | -3 | 0.816 |
PKN3 |
0.864 | 0.139 | -3 | 0.821 |
PRPK |
0.864 | -0.068 | -1 | 0.839 |
MTOR |
0.864 | 0.010 | 1 | 0.826 |
NEK6 |
0.864 | 0.118 | -2 | 0.882 |
TGFBR2 |
0.862 | 0.118 | -2 | 0.852 |
CAMK1B |
0.861 | 0.056 | -3 | 0.850 |
NEK7 |
0.861 | 0.051 | -3 | 0.845 |
CAMK2G |
0.861 | 0.018 | 2 | 0.795 |
NLK |
0.860 | 0.081 | 1 | 0.847 |
MST4 |
0.860 | 0.159 | 2 | 0.920 |
ULK2 |
0.859 | -0.049 | 2 | 0.807 |
BMPR2 |
0.859 | -0.000 | -2 | 0.876 |
RAF1 |
0.859 | -0.053 | 1 | 0.865 |
IKKB |
0.859 | -0.077 | -2 | 0.704 |
ATR |
0.858 | 0.030 | 1 | 0.868 |
RSK2 |
0.858 | 0.105 | -3 | 0.752 |
PKCD |
0.858 | 0.170 | 2 | 0.862 |
CDKL1 |
0.857 | 0.053 | -3 | 0.803 |
NUAK2 |
0.857 | 0.079 | -3 | 0.808 |
MLK1 |
0.857 | 0.067 | 2 | 0.871 |
TBK1 |
0.857 | -0.067 | 1 | 0.773 |
PDHK4 |
0.856 | -0.226 | 1 | 0.884 |
NDR1 |
0.856 | 0.049 | -3 | 0.802 |
PKN2 |
0.855 | 0.109 | -3 | 0.817 |
NIK |
0.855 | 0.058 | -3 | 0.870 |
PIM1 |
0.854 | 0.105 | -3 | 0.746 |
KIS |
0.853 | 0.079 | 1 | 0.700 |
IKKE |
0.853 | -0.093 | 1 | 0.764 |
BMPR1B |
0.853 | 0.212 | 1 | 0.834 |
ERK5 |
0.852 | 0.050 | 1 | 0.834 |
WNK1 |
0.852 | 0.025 | -2 | 0.847 |
P90RSK |
0.852 | 0.056 | -3 | 0.762 |
PDHK1 |
0.852 | -0.155 | 1 | 0.858 |
FAM20C |
0.851 | 0.084 | 2 | 0.560 |
GRK6 |
0.851 | 0.049 | 1 | 0.885 |
GRK5 |
0.851 | -0.068 | -3 | 0.862 |
RSK3 |
0.851 | 0.054 | -3 | 0.759 |
LATS2 |
0.851 | 0.028 | -5 | 0.755 |
RIPK3 |
0.851 | -0.033 | 3 | 0.764 |
CDKL5 |
0.851 | 0.065 | -3 | 0.784 |
PLK1 |
0.851 | 0.125 | -2 | 0.852 |
CAMLCK |
0.851 | 0.026 | -2 | 0.834 |
DAPK2 |
0.850 | 0.036 | -3 | 0.856 |
SKMLCK |
0.850 | 0.031 | -2 | 0.852 |
TGFBR1 |
0.850 | 0.165 | -2 | 0.845 |
P70S6KB |
0.850 | 0.057 | -3 | 0.775 |
MARK4 |
0.849 | 0.002 | 4 | 0.848 |
AMPKA1 |
0.849 | 0.032 | -3 | 0.816 |
PRKD1 |
0.849 | 0.013 | -3 | 0.791 |
ATM |
0.849 | 0.059 | 1 | 0.813 |
PRKD2 |
0.849 | 0.056 | -3 | 0.733 |
MLK3 |
0.848 | 0.125 | 2 | 0.829 |
GRK1 |
0.848 | 0.049 | -2 | 0.762 |
IKKA |
0.848 | -0.012 | -2 | 0.700 |
ANKRD3 |
0.848 | 0.049 | 1 | 0.891 |
HUNK |
0.848 | -0.071 | 2 | 0.760 |
ALK4 |
0.848 | 0.122 | -2 | 0.860 |
PKACG |
0.848 | 0.055 | -2 | 0.764 |
ULK1 |
0.847 | -0.121 | -3 | 0.822 |
NEK9 |
0.847 | -0.014 | 2 | 0.869 |
BCKDK |
0.847 | -0.084 | -1 | 0.824 |
GRK7 |
0.846 | 0.153 | 1 | 0.824 |
SRPK1 |
0.846 | 0.052 | -3 | 0.752 |
CAMK2D |
0.846 | -0.017 | -3 | 0.815 |
WNK3 |
0.845 | -0.143 | 1 | 0.846 |
PKCB |
0.845 | 0.130 | 2 | 0.826 |
CHAK2 |
0.845 | -0.054 | -1 | 0.811 |
TSSK2 |
0.845 | 0.024 | -5 | 0.769 |
CAMK2B |
0.845 | 0.063 | 2 | 0.750 |
PKCA |
0.845 | 0.137 | 2 | 0.821 |
AURC |
0.845 | 0.083 | -2 | 0.677 |
NUAK1 |
0.845 | 0.055 | -3 | 0.760 |
PKCG |
0.845 | 0.111 | 2 | 0.821 |
TSSK1 |
0.845 | 0.050 | -3 | 0.837 |
HIPK4 |
0.845 | 0.011 | 1 | 0.796 |
LATS1 |
0.844 | 0.104 | -3 | 0.823 |
ACVR2A |
0.844 | 0.134 | -2 | 0.830 |
GRK4 |
0.844 | -0.054 | -2 | 0.825 |
ALK2 |
0.844 | 0.162 | -2 | 0.848 |
ACVR2B |
0.844 | 0.139 | -2 | 0.841 |
ICK |
0.844 | 0.006 | -3 | 0.823 |
AMPKA2 |
0.844 | 0.031 | -3 | 0.781 |
RSK4 |
0.843 | 0.093 | -3 | 0.718 |
MAPKAPK3 |
0.842 | -0.018 | -3 | 0.732 |
CAMK4 |
0.842 | -0.016 | -3 | 0.780 |
PLK3 |
0.842 | 0.069 | 2 | 0.730 |
SRPK2 |
0.841 | 0.058 | -3 | 0.669 |
PKR |
0.841 | 0.071 | 1 | 0.856 |
MAPKAPK2 |
0.841 | 0.036 | -3 | 0.683 |
PKCH |
0.841 | 0.091 | 2 | 0.802 |
IRE1 |
0.840 | -0.035 | 1 | 0.809 |
TTBK2 |
0.840 | -0.125 | 2 | 0.710 |
DLK |
0.840 | -0.134 | 1 | 0.868 |
CAMK2A |
0.840 | 0.043 | 2 | 0.774 |
AURB |
0.840 | 0.070 | -2 | 0.674 |
IRE2 |
0.840 | 0.021 | 2 | 0.805 |
MLK4 |
0.840 | 0.045 | 2 | 0.788 |
NIM1 |
0.840 | -0.041 | 3 | 0.805 |
MLK2 |
0.840 | -0.076 | 2 | 0.858 |
PHKG1 |
0.839 | 0.045 | -3 | 0.789 |
MSK2 |
0.839 | -0.004 | -3 | 0.720 |
PKACB |
0.838 | 0.092 | -2 | 0.706 |
BMPR1A |
0.838 | 0.185 | 1 | 0.810 |
CDK8 |
0.838 | -0.004 | 1 | 0.666 |
MASTL |
0.837 | -0.291 | -2 | 0.784 |
PRKD3 |
0.837 | 0.022 | -3 | 0.728 |
RIPK1 |
0.837 | -0.170 | 1 | 0.853 |
YSK4 |
0.837 | -0.012 | 1 | 0.798 |
SGK3 |
0.837 | 0.094 | -3 | 0.732 |
NEK2 |
0.837 | -0.003 | 2 | 0.855 |
SRPK3 |
0.837 | 0.026 | -3 | 0.740 |
MELK |
0.836 | -0.007 | -3 | 0.769 |
QIK |
0.836 | -0.048 | -3 | 0.809 |
PAK1 |
0.836 | -0.016 | -2 | 0.758 |
CLK4 |
0.836 | 0.061 | -3 | 0.743 |
MYLK4 |
0.835 | 0.027 | -2 | 0.769 |
MNK2 |
0.835 | 0.013 | -2 | 0.795 |
CLK1 |
0.835 | 0.079 | -3 | 0.722 |
TLK2 |
0.835 | 0.010 | 1 | 0.826 |
QSK |
0.835 | 0.006 | 4 | 0.828 |
CDK5 |
0.835 | 0.074 | 1 | 0.697 |
SIK |
0.835 | 0.010 | -3 | 0.733 |
MSK1 |
0.835 | 0.037 | -3 | 0.723 |
PKCZ |
0.834 | 0.019 | 2 | 0.835 |
PKG2 |
0.834 | 0.068 | -2 | 0.703 |
MEK1 |
0.834 | -0.121 | 2 | 0.829 |
PRKX |
0.834 | 0.112 | -3 | 0.631 |
DRAK1 |
0.834 | 0.015 | 1 | 0.853 |
PAK3 |
0.834 | -0.054 | -2 | 0.754 |
AKT2 |
0.834 | 0.074 | -3 | 0.668 |
CDK1 |
0.833 | 0.057 | 1 | 0.643 |
AURA |
0.833 | 0.047 | -2 | 0.647 |
PIM2 |
0.832 | 0.072 | -3 | 0.722 |
BRSK1 |
0.832 | -0.029 | -3 | 0.769 |
CAMK1G |
0.832 | 0.012 | -3 | 0.749 |
MNK1 |
0.832 | 0.019 | -2 | 0.805 |
CLK2 |
0.831 | 0.102 | -3 | 0.733 |
HRI |
0.831 | -0.034 | -2 | 0.855 |
VRK2 |
0.831 | -0.185 | 1 | 0.888 |
CDK19 |
0.831 | -0.010 | 1 | 0.620 |
PERK |
0.831 | -0.036 | -2 | 0.847 |
SMG1 |
0.830 | -0.014 | 1 | 0.811 |
CHAK1 |
0.830 | -0.102 | 2 | 0.796 |
MARK2 |
0.830 | -0.012 | 4 | 0.759 |
GRK2 |
0.830 | -0.029 | -2 | 0.708 |
DNAPK |
0.830 | 0.021 | 1 | 0.742 |
CDK2 |
0.830 | 0.038 | 1 | 0.732 |
MARK3 |
0.829 | -0.009 | 4 | 0.788 |
PAK2 |
0.829 | -0.050 | -2 | 0.739 |
TLK1 |
0.829 | 0.010 | -2 | 0.863 |
DYRK2 |
0.829 | 0.006 | 1 | 0.695 |
DCAMKL1 |
0.828 | 0.020 | -3 | 0.747 |
MST3 |
0.828 | 0.113 | 2 | 0.883 |
JNK3 |
0.828 | 0.026 | 1 | 0.669 |
NEK5 |
0.828 | 0.026 | 1 | 0.860 |
MEKK3 |
0.828 | -0.065 | 1 | 0.828 |
PKCT |
0.828 | 0.072 | 2 | 0.812 |
PLK4 |
0.828 | -0.051 | 2 | 0.614 |
ZAK |
0.827 | -0.030 | 1 | 0.814 |
P38A |
0.827 | 0.027 | 1 | 0.715 |
CDK7 |
0.827 | -0.035 | 1 | 0.678 |
AKT1 |
0.827 | 0.089 | -3 | 0.675 |
MEKK1 |
0.827 | -0.050 | 1 | 0.834 |
BRAF |
0.827 | -0.042 | -4 | 0.795 |
CDK18 |
0.826 | 0.037 | 1 | 0.605 |
CDK13 |
0.826 | -0.016 | 1 | 0.652 |
HIPK1 |
0.826 | 0.057 | 1 | 0.709 |
ERK2 |
0.826 | 0.004 | 1 | 0.687 |
JNK2 |
0.826 | 0.039 | 1 | 0.622 |
SMMLCK |
0.826 | 0.020 | -3 | 0.810 |
BRSK2 |
0.826 | -0.090 | -3 | 0.781 |
MEKK2 |
0.825 | -0.010 | 2 | 0.837 |
CHK1 |
0.825 | -0.061 | -3 | 0.768 |
ERK1 |
0.825 | 0.020 | 1 | 0.631 |
TAO3 |
0.824 | 0.039 | 1 | 0.824 |
NEK8 |
0.824 | 0.021 | 2 | 0.862 |
MARK1 |
0.823 | -0.047 | 4 | 0.807 |
MEK5 |
0.823 | -0.178 | 2 | 0.842 |
SNRK |
0.823 | -0.168 | 2 | 0.699 |
PHKG2 |
0.823 | 0.017 | -3 | 0.774 |
PRP4 |
0.823 | 0.086 | -3 | 0.836 |
P38G |
0.823 | 0.033 | 1 | 0.546 |
PKACA |
0.822 | 0.064 | -2 | 0.659 |
PINK1 |
0.822 | -0.132 | 1 | 0.840 |
DCAMKL2 |
0.822 | -0.001 | -3 | 0.773 |
CDK3 |
0.822 | 0.079 | 1 | 0.574 |
CK2A2 |
0.822 | 0.168 | 1 | 0.761 |
HIPK2 |
0.822 | 0.043 | 1 | 0.602 |
P70S6K |
0.822 | 0.006 | -3 | 0.688 |
PASK |
0.822 | 0.002 | -3 | 0.835 |
WNK4 |
0.822 | -0.089 | -2 | 0.831 |
P38B |
0.821 | 0.020 | 1 | 0.649 |
CDK17 |
0.821 | 0.019 | 1 | 0.555 |
IRAK4 |
0.821 | -0.065 | 1 | 0.818 |
PAK6 |
0.820 | -0.033 | -2 | 0.669 |
DYRK1A |
0.820 | 0.006 | 1 | 0.749 |
PKCE |
0.820 | 0.110 | 2 | 0.809 |
GSK3A |
0.820 | 0.054 | 4 | 0.474 |
CDK12 |
0.819 | -0.010 | 1 | 0.626 |
CAMK1D |
0.819 | 0.024 | -3 | 0.646 |
PKCI |
0.819 | 0.040 | 2 | 0.821 |
ERK7 |
0.819 | 0.085 | 2 | 0.625 |
MAPKAPK5 |
0.819 | -0.129 | -3 | 0.702 |
CDK16 |
0.819 | 0.076 | 1 | 0.574 |
MST2 |
0.819 | 0.075 | 1 | 0.826 |
GRK3 |
0.818 | -0.021 | -2 | 0.676 |
SSTK |
0.818 | -0.021 | 4 | 0.826 |
CK1E |
0.818 | -0.063 | -3 | 0.496 |
EEF2K |
0.818 | 0.085 | 3 | 0.839 |
DAPK3 |
0.817 | 0.048 | -3 | 0.775 |
CDK14 |
0.817 | 0.031 | 1 | 0.649 |
HIPK3 |
0.817 | 0.006 | 1 | 0.715 |
CDK9 |
0.817 | -0.039 | 1 | 0.656 |
TAO2 |
0.816 | 0.001 | 2 | 0.891 |
TTBK1 |
0.816 | -0.136 | 2 | 0.631 |
NEK11 |
0.816 | -0.085 | 1 | 0.843 |
PLK2 |
0.815 | 0.050 | -3 | 0.802 |
GAK |
0.815 | -0.007 | 1 | 0.845 |
AKT3 |
0.814 | 0.085 | -3 | 0.598 |
GSK3B |
0.814 | -0.013 | 4 | 0.465 |
PDK1 |
0.814 | -0.019 | 1 | 0.869 |
SGK1 |
0.814 | 0.085 | -3 | 0.581 |
CDK10 |
0.814 | 0.056 | 1 | 0.635 |
GCK |
0.813 | 0.028 | 1 | 0.822 |
PKN1 |
0.813 | 0.056 | -3 | 0.697 |
DYRK1B |
0.813 | 0.005 | 1 | 0.656 |
TNIK |
0.812 | 0.065 | 3 | 0.848 |
DYRK3 |
0.811 | 0.019 | 1 | 0.708 |
DAPK1 |
0.811 | 0.032 | -3 | 0.763 |
CAMK1A |
0.811 | 0.043 | -3 | 0.634 |
MST1 |
0.811 | 0.051 | 1 | 0.808 |
CAMKK1 |
0.810 | -0.176 | -2 | 0.708 |
NEK4 |
0.810 | -0.061 | 1 | 0.804 |
CK2A1 |
0.810 | 0.130 | 1 | 0.741 |
CK1G1 |
0.810 | -0.095 | -3 | 0.522 |
P38D |
0.810 | 0.026 | 1 | 0.554 |
MRCKA |
0.809 | 0.071 | -3 | 0.720 |
TAK1 |
0.809 | -0.005 | 1 | 0.862 |
HGK |
0.809 | -0.000 | 3 | 0.846 |
CK1D |
0.808 | -0.064 | -3 | 0.442 |
MPSK1 |
0.808 | -0.071 | 1 | 0.781 |
DYRK4 |
0.808 | -0.007 | 1 | 0.619 |
MRCKB |
0.808 | 0.063 | -3 | 0.715 |
MINK |
0.808 | -0.015 | 1 | 0.808 |
NEK1 |
0.808 | 0.003 | 1 | 0.828 |
PDHK3_TYR |
0.807 | 0.160 | 4 | 0.896 |
MAP3K15 |
0.806 | -0.070 | 1 | 0.801 |
ROCK2 |
0.806 | 0.072 | -3 | 0.747 |
LKB1 |
0.806 | -0.128 | -3 | 0.837 |
LOK |
0.806 | -0.015 | -2 | 0.747 |
CHK2 |
0.806 | 0.006 | -3 | 0.606 |
CAMKK2 |
0.805 | -0.171 | -2 | 0.701 |
HPK1 |
0.805 | -0.009 | 1 | 0.807 |
MEKK6 |
0.805 | -0.093 | 1 | 0.819 |
LRRK2 |
0.804 | -0.122 | 2 | 0.869 |
CK1A2 |
0.804 | -0.079 | -3 | 0.441 |
TTK |
0.804 | 0.115 | -2 | 0.870 |
IRAK1 |
0.804 | -0.289 | -1 | 0.730 |
VRK1 |
0.803 | -0.112 | 2 | 0.832 |
KHS2 |
0.803 | 0.060 | 1 | 0.807 |
YSK1 |
0.803 | 0.021 | 2 | 0.869 |
KHS1 |
0.802 | 0.025 | 1 | 0.794 |
JNK1 |
0.802 | -0.013 | 1 | 0.618 |
CDK6 |
0.802 | 0.011 | 1 | 0.624 |
PAK5 |
0.801 | -0.068 | -2 | 0.611 |
DMPK1 |
0.801 | 0.089 | -3 | 0.733 |
SLK |
0.800 | -0.075 | -2 | 0.688 |
PDHK4_TYR |
0.799 | 0.048 | 2 | 0.866 |
TESK1_TYR |
0.799 | -0.009 | 3 | 0.886 |
MAK |
0.799 | 0.044 | -2 | 0.673 |
MAP2K4_TYR |
0.799 | -0.007 | -1 | 0.871 |
MAP2K7_TYR |
0.798 | -0.082 | 2 | 0.852 |
MOK |
0.797 | 0.041 | 1 | 0.731 |
MAP2K6_TYR |
0.797 | -0.001 | -1 | 0.863 |
BMPR2_TYR |
0.797 | 0.028 | -1 | 0.850 |
OSR1 |
0.797 | 0.018 | 2 | 0.839 |
PDHK1_TYR |
0.797 | 0.013 | -1 | 0.872 |
MEK2 |
0.797 | -0.206 | 2 | 0.810 |
RIPK2 |
0.797 | -0.217 | 1 | 0.778 |
BUB1 |
0.796 | 0.028 | -5 | 0.750 |
PAK4 |
0.796 | -0.070 | -2 | 0.623 |
CDK4 |
0.796 | -0.013 | 1 | 0.609 |
PINK1_TYR |
0.795 | -0.064 | 1 | 0.882 |
STK33 |
0.795 | -0.179 | 2 | 0.626 |
ROCK1 |
0.795 | 0.057 | -3 | 0.720 |
PKMYT1_TYR |
0.793 | -0.090 | 3 | 0.863 |
SBK |
0.793 | 0.003 | -3 | 0.545 |
PKG1 |
0.793 | 0.003 | -2 | 0.630 |
LIMK2_TYR |
0.792 | 0.004 | -3 | 0.872 |
NEK3 |
0.792 | -0.099 | 1 | 0.787 |
EPHA6 |
0.792 | 0.052 | -1 | 0.856 |
RET |
0.791 | -0.033 | 1 | 0.837 |
CRIK |
0.790 | 0.036 | -3 | 0.668 |
EPHB4 |
0.789 | 0.033 | -1 | 0.864 |
ALPHAK3 |
0.789 | -0.026 | -1 | 0.765 |
TYK2 |
0.789 | -0.051 | 1 | 0.834 |
MYO3B |
0.789 | 0.022 | 2 | 0.880 |
HASPIN |
0.789 | -0.018 | -1 | 0.642 |
ROS1 |
0.788 | -0.010 | 3 | 0.795 |
LIMK1_TYR |
0.788 | -0.109 | 2 | 0.868 |
INSRR |
0.787 | 0.021 | 3 | 0.778 |
TYRO3 |
0.787 | -0.056 | 3 | 0.815 |
PBK |
0.786 | -0.100 | 1 | 0.753 |
MST1R |
0.786 | -0.070 | 3 | 0.823 |
MYO3A |
0.786 | 0.006 | 1 | 0.793 |
TXK |
0.786 | 0.081 | 1 | 0.864 |
YES1 |
0.785 | -0.008 | -1 | 0.823 |
JAK2 |
0.785 | -0.068 | 1 | 0.831 |
CSF1R |
0.784 | -0.050 | 3 | 0.810 |
DDR1 |
0.784 | -0.093 | 4 | 0.825 |
TAO1 |
0.784 | -0.042 | 1 | 0.752 |
ASK1 |
0.784 | -0.128 | 1 | 0.792 |
JAK3 |
0.783 | -0.026 | 1 | 0.837 |
FGR |
0.783 | -0.033 | 1 | 0.876 |
ABL2 |
0.783 | -0.013 | -1 | 0.793 |
FER |
0.782 | -0.074 | 1 | 0.899 |
KDR |
0.781 | -0.001 | 3 | 0.774 |
EPHB1 |
0.781 | 0.008 | 1 | 0.878 |
BIKE |
0.780 | -0.046 | 1 | 0.699 |
EPHA4 |
0.780 | -0.021 | 2 | 0.724 |
PDGFRB |
0.779 | -0.076 | 3 | 0.824 |
LCK |
0.779 | 0.017 | -1 | 0.795 |
BLK |
0.779 | 0.048 | -1 | 0.801 |
HCK |
0.779 | -0.038 | -1 | 0.801 |
EPHB2 |
0.778 | 0.016 | -1 | 0.846 |
EPHB3 |
0.778 | -0.019 | -1 | 0.848 |
FGFR2 |
0.778 | -0.088 | 3 | 0.814 |
JAK1 |
0.777 | 0.008 | 1 | 0.776 |
SRMS |
0.777 | -0.057 | 1 | 0.883 |
ABL1 |
0.777 | -0.051 | -1 | 0.786 |
KIT |
0.777 | -0.089 | 3 | 0.815 |
TNK2 |
0.776 | -0.054 | 3 | 0.780 |
ITK |
0.776 | -0.045 | -1 | 0.784 |
FLT3 |
0.776 | -0.084 | 3 | 0.804 |
NEK10_TYR |
0.776 | -0.062 | 1 | 0.734 |
TNNI3K_TYR |
0.776 | 0.004 | 1 | 0.818 |
TEC |
0.776 | -0.011 | -1 | 0.742 |
FLT1 |
0.775 | -0.004 | -1 | 0.839 |
MERTK |
0.775 | -0.040 | 3 | 0.787 |
YANK3 |
0.774 | -0.104 | 2 | 0.398 |
WEE1_TYR |
0.773 | -0.055 | -1 | 0.749 |
ALK |
0.773 | -0.056 | 3 | 0.762 |
FGFR1 |
0.773 | -0.103 | 3 | 0.796 |
LTK |
0.773 | -0.052 | 3 | 0.780 |
PDGFRA |
0.771 | -0.143 | 3 | 0.822 |
AXL |
0.771 | -0.115 | 3 | 0.795 |
TEK |
0.771 | -0.147 | 3 | 0.766 |
TNK1 |
0.771 | -0.103 | 3 | 0.792 |
CK1A |
0.771 | -0.093 | -3 | 0.357 |
STLK3 |
0.771 | -0.172 | 1 | 0.771 |
MET |
0.770 | -0.091 | 3 | 0.797 |
EPHA7 |
0.770 | -0.031 | 2 | 0.738 |
BMX |
0.770 | -0.054 | -1 | 0.712 |
FYN |
0.769 | -0.009 | -1 | 0.767 |
NTRK1 |
0.769 | -0.130 | -1 | 0.833 |
BTK |
0.768 | -0.144 | -1 | 0.763 |
FGFR3 |
0.768 | -0.094 | 3 | 0.789 |
NTRK2 |
0.768 | -0.106 | 3 | 0.773 |
ERBB2 |
0.768 | -0.122 | 1 | 0.803 |
EPHA3 |
0.767 | -0.080 | 2 | 0.708 |
DDR2 |
0.767 | -0.002 | 3 | 0.776 |
FLT4 |
0.767 | -0.105 | 3 | 0.773 |
FRK |
0.767 | -0.058 | -1 | 0.820 |
INSR |
0.767 | -0.095 | 3 | 0.753 |
EPHA5 |
0.766 | -0.014 | 2 | 0.708 |
NTRK3 |
0.765 | -0.091 | -1 | 0.787 |
PTK6 |
0.764 | -0.196 | -1 | 0.725 |
LYN |
0.763 | -0.077 | 3 | 0.744 |
EPHA1 |
0.763 | -0.111 | 3 | 0.776 |
EGFR |
0.762 | -0.041 | 1 | 0.723 |
AAK1 |
0.761 | -0.010 | 1 | 0.583 |
PTK2B |
0.761 | -0.059 | -1 | 0.762 |
MATK |
0.760 | -0.112 | -1 | 0.723 |
EPHA8 |
0.760 | -0.069 | -1 | 0.807 |
PTK2 |
0.760 | 0.025 | -1 | 0.778 |
SYK |
0.759 | 0.020 | -1 | 0.766 |
SRC |
0.758 | -0.088 | -1 | 0.773 |
FGFR4 |
0.756 | -0.086 | -1 | 0.783 |
CK1G3 |
0.755 | -0.085 | -3 | 0.319 |
IGF1R |
0.754 | -0.096 | 3 | 0.700 |
MUSK |
0.753 | -0.097 | 1 | 0.719 |
EPHA2 |
0.753 | -0.049 | -1 | 0.793 |
CSK |
0.751 | -0.190 | 2 | 0.745 |
ERBB4 |
0.744 | -0.075 | 1 | 0.736 |
YANK2 |
0.742 | -0.132 | 2 | 0.419 |
CK1G2 |
0.734 | -0.098 | -3 | 0.428 |
FES |
0.733 | -0.154 | -1 | 0.695 |
ZAP70 |
0.731 | -0.073 | -1 | 0.673 |