Motif 934 (n=114)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NF01 | POM121B | Y547 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A8CG34 | POM121C | Y940 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00141 | SGK1 | S410 | ochoa | Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. {ECO:0000269|PubMed:11154281, ECO:0000269|PubMed:11410590, ECO:0000269|PubMed:11696533, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12761204, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15234985, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15733869, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16443776, ECO:0000269|PubMed:16982696, ECO:0000269|PubMed:17382906, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:18753299, ECO:0000269|PubMed:19447520, ECO:0000269|PubMed:19756449, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:20730100, ECO:0000269|PubMed:21865597}. |
| O00411 | POLRMT | S666 | ochoa | DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) | DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}. |
| O00515 | LAD1 | S485 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14559 | ARHGAP33 | S633 | ochoa | Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein) | May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). {ECO:0000250}. |
| O15061 | SYNM | S1504 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43852 | CALU | S44 | ochoa | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| O60292 | SIPA1L3 | S1239 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60503 | ADCY9 | S1307 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O95208 | EPN2 | S420 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95425 | SVIL | S1399 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95630 | STAMBP | S48 | psp | STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699, ECO:0000269|PubMed:34425109}. |
| O95817 | BAG3 | S224 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O96028 | NSD2 | S369 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P00450 | CP | S499 | ochoa | Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) (Glutathione peroxidase ceruloplasmin) (EC 1.11.1.9) (Glutathione-dependent peroxiredoxin ceruloplasmin) (EC 1.11.1.27) | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150). {ECO:0000250|UniProtKB:P13635, ECO:0000269|PubMed:10481051, ECO:0000269|PubMed:14623105, ECO:0000269|PubMed:16150804, ECO:0000269|PubMed:16906150, ECO:0000269|PubMed:4643313, ECO:0000269|PubMed:5912351}. |
| P05062 | ALDOB | S161 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P18206 | VCL | S260 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19438 | TNFRSF1A | S350 | ochoa | Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| P26232 | CTNNA2 | S321 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P26640 | VARS1 | Y1227 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P32780 | GTF2H1 | S158 | ochoa | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:9852112}. |
| P35221 | CTNNA1 | S323 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P40189 | IL6ST | S862 | ochoa | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) | Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:19915009, PubMed:2261637, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}. |
| P42331 | ARHGAP25 | S521 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P46937 | YAP1 | S217 | psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P49757 | NUMB | S361 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49790 | NUP153 | S1047 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51610 | HCFC1 | S1398 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P53814 | SMTN | S277 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P55017 | SLC12A3 | S91 | psp | Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) | Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). {ECO:0000250|UniProtKB:P59158, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22009145, ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}. |
| P78559 | MAP1A | S1264 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98175 | RBM10 | S492 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q01167 | FOXK2 | S599 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q08AD1 | CAMSAP2 | S374 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12955 | ANK3 | S2009 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13428 | TCOF1 | S846 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13671 | RIN1 | S356 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14644 | RASA3 | S528 | ochoa | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Q14686 | NCOA6 | S1432 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14694 | USP10 | S97 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q15334 | LLGL1 | S682 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q16665 | HIF1A | S643 | ochoa|psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16891 | IMMT | S555 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q29RF7 | PDS5A | S1232 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q5QJE6 | DNTTIP2 | S273 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SXM2 | SNAPC4 | S1170 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5SYE7 | NHSL1 | S1233 | ochoa | NHS-like protein 1 | None |
| Q5VV67 | PPRC1 | S1076 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q68CZ2 | TNS3 | S399 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6AI08 | HEATR6 | S1124 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6W2J9 | BCOR | S389 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q7Z5K2 | WAPL | S190 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6J0 | SH3RF1 | S551 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q7Z6M3 | MILR1 | S308 | ochoa | Allergin-1 (Allergy inhibitory receptor 1) (Mast cell antigen 32) (MCA-32) (Mast cell immunoglobulin-like receptor 1) | Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity). {ECO:0000250}. |
| Q86UZ6 | ZBTB46 | S324 | ochoa | Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) | Functions as a transcriptional repressor for PRDM1. {ECO:0000250}. |
| Q86XP3 | DDX42 | S717 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8IV61 | RASGRP3 | S597 | ochoa | Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1) | Guanine nucleotide exchange factor (GEF) for Ras and Rap1. {ECO:0000269|PubMed:10934204}. |
| Q8IVM0 | CCDC50 | S32 | ochoa | Coiled-coil domain-containing protein 50 (Protein Ymer) | Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}. |
| Q8N0Z3 | SPICE1 | S232 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N3J3 | HROB | S351 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N4X5 | AFAP1L2 | S767 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8NBR6 | MINDY2 | S25 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
| Q8NEZ4 | KMT2C | S177 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TD55 | PLEKHO2 | S273 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TF76 | HASPIN | S389 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q92541 | RTF1 | S675 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92545 | TMEM131 | S1649 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92574 | TSC1 | S483 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92576 | PHF3 | S1722 | ochoa | PHD finger protein 3 | None |
| Q92736 | RYR2 | S2814 | psp | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q96D71 | REPS1 | S736 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96F05 | C11orf24 | S61 | ochoa | Uncharacterized protein C11orf24 (Protein DM4E3) | None |
| Q96HA1 | POM121 | Y963 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96J01 | THOC3 | S273 | ochoa | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96KG9 | SCYL1 | S559 | ochoa | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}. |
| Q96RT7 | TUBGCP6 | S1397 | ochoa|psp | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96T21 | SECISBP2 | S288 | ochoa | Selenocysteine insertion sequence-binding protein 2 (SECIS-binding protein 2) | mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:35709277). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (PubMed:35709277). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (PubMed:35709277). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (PubMed:35709277). {ECO:0000269|PubMed:35709277}. |
| Q99590 | SCAF11 | S360 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99988 | GDF15 | S97 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BSW7 | SYT17 | S66 | ochoa | Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) | Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9BTC0 | DIDO1 | S111 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BV73 | CEP250 | S2390 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BZS1 | FOXP3 | S274 | psp | Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}. |
| Q9GZM8 | NDEL1 | S198 | ochoa|psp | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9H211 | CDT1 | S93 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H9Q2 | COPS7B | S225 | ochoa | COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}. |
| Q9HC84 | MUC5B | S2763 | ochoa | Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin) | Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. |
| Q9HCJ3 | RAVER2 | S622 | ochoa | Ribonucleoprotein PTB-binding 2 (Protein raver-2) | May bind single-stranded nucleic acids. {ECO:0000305}. |
| Q9NQ66 | PLCB1 | S887 | psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. {ECO:0000250|UniProtKB:Q9Z1B3, ECO:0000269|PubMed:9188725}. |
| Q9NR48 | ASH1L | S1791 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NW75 | GPATCH2 | S284 | ochoa | G patch domain-containing protein 2 | Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}. |
| Q9UHF7 | TRPS1 | S1009 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UK76 | JPT1 | S49 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9Y3R0 | GRIP1 | S1097 | ochoa | Glutamate receptor-interacting protein 1 (GRIP-1) | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}. |
| Q9Y467 | SALL2 | S797 | ochoa | Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) | Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. {ECO:0000269|PubMed:24412933}. |
| Q9Y490 | TLN1 | S992 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4D2 | DAGLA | S847 | ochoa | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}. |
| Q9Y6J0 | CABIN1 | S1744 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6J9 | TAF6L | S481 | ochoa | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha) | Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). {ECO:0000250|UniProtKB:Q8R2K4, ECO:0000305|PubMed:9674419}. |
| V9GYH0 | None | S31 | ochoa | Homeobox domain-containing protein | None |
| Q96RT7 | TUBGCP6 | S1060 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1087 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1114 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1168 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1195 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1249 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| O95757 | HSPA4L | S40 | Sugiyama | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}. |
| P36888 | FLT3 | S618 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| O95273 | CCNDBP1 | S313 | GPS6 | Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid) | May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. {ECO:0000269|PubMed:10801854}. |
| Q9NQR4 | NIT2 | S207 | Sugiyama | Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) | Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}. |
| O75688 | PPM1B | S186 | Sugiyama | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| P35813 | PPM1A | S181 | Sugiyama | Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}. |
| O00273 | DFFA | S90 | Sugiyama | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 0.007363 | 2.133 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 0.007363 | 2.133 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.002580 | 2.588 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.004298 | 2.367 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.002522 | 2.598 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.002723 | 2.565 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.002723 | 2.565 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.003155 | 2.501 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.003155 | 2.501 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.003386 | 2.470 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.003878 | 2.411 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.004987 | 2.302 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.005292 | 2.276 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.003212 | 2.493 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.004655 | 2.332 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.000294 | 3.532 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.007209 | 2.142 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.001507 | 2.822 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.005667 | 2.247 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.004411 | 2.355 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.007350 | 2.134 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.003386 | 2.470 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.005607 | 2.251 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.001603 | 2.795 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.003627 | 2.440 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.005292 | 2.276 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.005292 | 2.276 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.005607 | 2.251 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.000559 | 3.253 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.000459 | 3.338 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.003878 | 2.411 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.004694 | 2.328 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.007732 | 2.112 |
| R-HSA-3371556 | Cellular response to heat stress | 0.003434 | 2.464 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.004987 | 2.302 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.003502 | 2.456 |
| R-HSA-1640170 | Cell Cycle | 0.007897 | 2.103 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.008919 | 2.050 |
| R-HSA-70171 | Glycolysis | 0.009576 | 2.019 |
| R-HSA-68886 | M Phase | 0.010394 | 1.983 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.010789 | 1.967 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.011991 | 1.921 |
| R-HSA-5619102 | SLC transporter disorders | 0.012436 | 1.905 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.012722 | 1.895 |
| R-HSA-5657560 | Hereditary fructose intolerance | 0.014672 | 1.834 |
| R-HSA-191859 | snRNP Assembly | 0.013787 | 1.861 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.013787 | 1.861 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.013503 | 1.870 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.013870 | 1.858 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.014623 | 1.835 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.014900 | 1.827 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.015476 | 1.810 |
| R-HSA-70326 | Glucose metabolism | 0.016618 | 1.779 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.017901 | 1.747 |
| R-HSA-5619087 | Defective SLC12A3 causes Gitelman syndrome (GS) | 0.021928 | 1.659 |
| R-HSA-525793 | Myogenesis | 0.023778 | 1.624 |
| R-HSA-163282 | Mitochondrial transcription initiation | 0.021928 | 1.659 |
| R-HSA-68877 | Mitotic Prometaphase | 0.021050 | 1.677 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.021915 | 1.659 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.024119 | 1.618 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.027969 | 1.553 |
| R-HSA-5619049 | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | 0.029131 | 1.536 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 0.029131 | 1.536 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.029528 | 1.530 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.030438 | 1.517 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.031496 | 1.502 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.036281 | 1.440 |
| R-HSA-162587 | HIV Life Cycle | 0.041501 | 1.382 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.039065 | 1.408 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.040907 | 1.388 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.040754 | 1.390 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.039372 | 1.405 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.042471 | 1.372 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.043379 | 1.363 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.043379 | 1.363 |
| R-HSA-5619060 | Defective CP causes aceruloplasminemia (ACERULOP) | 0.043379 | 1.363 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.043379 | 1.363 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.050425 | 1.297 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.057420 | 1.241 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.051445 | 1.289 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.051445 | 1.289 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.054217 | 1.266 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.045983 | 1.337 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.057420 | 1.241 |
| R-HSA-165159 | MTOR signalling | 0.053314 | 1.273 |
| R-HSA-5688426 | Deubiquitination | 0.054029 | 1.267 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.055570 | 1.255 |
| R-HSA-4839726 | Chromatin organization | 0.050057 | 1.301 |
| R-HSA-201556 | Signaling by ALK | 0.045983 | 1.337 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.048772 | 1.312 |
| R-HSA-211000 | Gene Silencing by RNA | 0.058839 | 1.230 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.061028 | 1.214 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.061028 | 1.214 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.061028 | 1.214 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.061028 | 1.214 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.061028 | 1.214 |
| R-HSA-9645135 | STAT5 Activation | 0.064363 | 1.191 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.064363 | 1.191 |
| R-HSA-1169092 | Activation of RAS in B cells | 0.078099 | 1.107 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.084891 | 1.071 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.104972 | 0.979 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.118116 | 0.928 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.118116 | 0.928 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.131069 | 0.883 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.137474 | 0.862 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.137474 | 0.862 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.137474 | 0.862 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.137474 | 0.862 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.150145 | 0.823 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.150145 | 0.823 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.156411 | 0.806 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.156411 | 0.806 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.187060 | 0.728 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.193056 | 0.714 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.193056 | 0.714 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.193056 | 0.714 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.216605 | 0.664 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.216605 | 0.664 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.111477 | 0.953 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.121101 | 0.917 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.125988 | 0.900 |
| R-HSA-380287 | Centrosome maturation | 0.125988 | 0.900 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.161372 | 0.792 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.192947 | 0.715 |
| R-HSA-354192 | Integrin signaling | 0.250656 | 0.601 |
| R-HSA-72086 | mRNA Capping | 0.228122 | 0.642 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.102069 | 0.991 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.214419 | 0.669 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.118116 | 0.928 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.216605 | 0.664 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.239472 | 0.621 |
| R-HSA-8849473 | PTK6 Expression | 0.071256 | 1.147 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.117423 | 0.930 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.075364 | 1.123 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.079091 | 1.102 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.148522 | 0.828 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.123538 | 0.908 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.091634 | 1.038 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.199008 | 0.701 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.211721 | 0.674 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.211721 | 0.674 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.124616 | 0.904 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.151075 | 0.821 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.135385 | 0.868 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.064363 | 1.191 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.071256 | 1.147 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.156411 | 0.806 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.156411 | 0.806 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.073255 | 1.135 |
| R-HSA-8949613 | Cristae formation | 0.216605 | 0.664 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.083990 | 1.076 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.091634 | 1.038 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.091634 | 1.038 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.111568 | 0.952 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.152482 | 0.817 |
| R-HSA-5689603 | UCH proteinases | 0.128449 | 0.891 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.064363 | 1.191 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.084891 | 1.071 |
| R-HSA-426048 | Arachidonate production from DAG | 0.091634 | 1.038 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.137474 | 0.862 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.174935 | 0.757 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.210782 | 0.676 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.222385 | 0.653 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.233818 | 0.631 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.250656 | 0.601 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.256186 | 0.591 |
| R-HSA-112040 | G-protein mediated events | 0.106744 | 0.972 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.233818 | 0.631 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.248783 | 0.604 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.210782 | 0.676 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.132051 | 0.879 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.118116 | 0.928 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.143833 | 0.842 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.143833 | 0.842 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.091634 | 1.038 |
| R-HSA-163615 | PKA activation | 0.156411 | 0.806 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.193056 | 0.714 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.075364 | 1.123 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.222385 | 0.653 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.110118 | 0.958 |
| R-HSA-2028269 | Signaling by Hippo | 0.150145 | 0.823 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.228122 | 0.642 |
| R-HSA-111885 | Opioid Signalling | 0.209027 | 0.680 |
| R-HSA-70350 | Fructose catabolism | 0.137474 | 0.862 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.162631 | 0.789 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.222385 | 0.653 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.256186 | 0.591 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.173797 | 0.760 |
| R-HSA-68882 | Mitotic Anaphase | 0.098445 | 1.007 |
| R-HSA-114608 | Platelet degranulation | 0.088788 | 1.052 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.099585 | 1.002 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.158196 | 0.801 |
| R-HSA-162906 | HIV Infection | 0.111318 | 0.953 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.187060 | 0.728 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.222385 | 0.653 |
| R-HSA-9609690 | HCMV Early Events | 0.213041 | 0.672 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.250656 | 0.601 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.079906 | 1.097 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.174935 | 0.757 |
| R-HSA-5652084 | Fructose metabolism | 0.187060 | 0.728 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.228122 | 0.642 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.256186 | 0.591 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.098959 | 1.005 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.137063 | 0.863 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.250656 | 0.601 |
| R-HSA-3214847 | HATs acetylate histones | 0.195616 | 0.709 |
| R-HSA-74160 | Gene expression (Transcription) | 0.214032 | 0.670 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.137474 | 0.862 |
| R-HSA-112043 | PLC beta mediated events | 0.092899 | 1.032 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.198290 | 0.703 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.174935 | 0.757 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.213041 | 0.672 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.233818 | 0.631 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.256186 | 0.591 |
| R-HSA-69242 | S Phase | 0.125471 | 0.901 |
| R-HSA-9610379 | HCMV Late Events | 0.140442 | 0.853 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.110984 | 0.955 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.170224 | 0.769 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.170224 | 0.769 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.210782 | 0.676 |
| R-HSA-397014 | Muscle contraction | 0.246044 | 0.609 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.083187 | 1.080 |
| R-HSA-373760 | L1CAM interactions | 0.249723 | 0.603 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.168423 | 0.774 |
| R-HSA-168255 | Influenza Infection | 0.181146 | 0.742 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.250656 | 0.601 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.222531 | 0.653 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.220720 | 0.656 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.246044 | 0.609 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 0.199008 | 0.701 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.128449 | 0.891 |
| R-HSA-449147 | Signaling by Interleukins | 0.202020 | 0.695 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.245084 | 0.611 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.256186 | 0.591 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.241547 | 0.617 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.133405 | 0.875 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.222531 | 0.653 |
| R-HSA-68875 | Mitotic Prophase | 0.077746 | 1.109 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.252450 | 0.598 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.090078 | 1.045 |
| R-HSA-2262752 | Cellular responses to stress | 0.238990 | 0.622 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.115837 | 0.936 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.219824 | 0.658 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.219824 | 0.658 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.169177 | 0.772 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.156207 | 0.806 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.171793 | 0.765 |
| R-HSA-72306 | tRNA processing | 0.164839 | 0.783 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.189755 | 0.722 |
| R-HSA-418990 | Adherens junctions interactions | 0.257888 | 0.589 |
| R-HSA-597592 | Post-translational protein modification | 0.258053 | 0.588 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.261677 | 0.582 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.261677 | 0.582 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.272537 | 0.565 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.272537 | 0.565 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.272537 | 0.565 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.272537 | 0.565 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.272537 | 0.565 |
| R-HSA-111933 | Calmodulin induced events | 0.272537 | 0.565 |
| R-HSA-111997 | CaM pathway | 0.272537 | 0.565 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.277017 | 0.557 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.277017 | 0.557 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.277017 | 0.557 |
| R-HSA-69206 | G1/S Transition | 0.277017 | 0.557 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.277795 | 0.556 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.283239 | 0.548 |
| R-HSA-8875878 | MET promotes cell motility | 0.283239 | 0.548 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.288531 | 0.540 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.288531 | 0.540 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.288531 | 0.540 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.293784 | 0.532 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.293784 | 0.532 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.293784 | 0.532 |
| R-HSA-167169 | HIV Transcription Elongation | 0.293784 | 0.532 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.293784 | 0.532 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.293784 | 0.532 |
| R-HSA-9607240 | FLT3 Signaling | 0.298999 | 0.524 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.298999 | 0.524 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.298999 | 0.524 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.304176 | 0.517 |
| R-HSA-167161 | HIV Transcription Initiation | 0.304176 | 0.517 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.304176 | 0.517 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.304176 | 0.517 |
| R-HSA-991365 | Activation of GABAB receptors | 0.309315 | 0.510 |
| R-HSA-977444 | GABA B receptor activation | 0.309315 | 0.510 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.309315 | 0.510 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.309315 | 0.510 |
| R-HSA-111996 | Ca-dependent events | 0.309315 | 0.510 |
| R-HSA-73894 | DNA Repair | 0.309357 | 0.510 |
| R-HSA-163685 | Integration of energy metabolism | 0.312405 | 0.505 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.314416 | 0.502 |
| R-HSA-8854214 | TBC/RABGAPs | 0.314416 | 0.502 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.317824 | 0.498 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.320530 | 0.494 |
| R-HSA-9609646 | HCMV Infection | 0.322029 | 0.492 |
| R-HSA-421270 | Cell-cell junction organization | 0.324046 | 0.489 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.324507 | 0.489 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.324507 | 0.489 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.324507 | 0.489 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.324507 | 0.489 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.324507 | 0.489 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.329497 | 0.482 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.329497 | 0.482 |
| R-HSA-75153 | Apoptotic execution phase | 0.329497 | 0.482 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.334133 | 0.476 |
| R-HSA-437239 | Recycling pathway of L1 | 0.334450 | 0.476 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.339367 | 0.469 |
| R-HSA-9634597 | GPER1 signaling | 0.339367 | 0.469 |
| R-HSA-70263 | Gluconeogenesis | 0.339367 | 0.469 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.339367 | 0.469 |
| R-HSA-425410 | Metal ion SLC transporters | 0.339367 | 0.469 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.342076 | 0.466 |
| R-HSA-9766229 | Degradation of CDH1 | 0.344248 | 0.463 |
| R-HSA-73893 | DNA Damage Bypass | 0.344248 | 0.463 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.344248 | 0.463 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.349094 | 0.457 |
| R-HSA-109704 | PI3K Cascade | 0.349094 | 0.457 |
| R-HSA-913531 | Interferon Signaling | 0.349473 | 0.457 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.353904 | 0.451 |
| R-HSA-72187 | mRNA 3'-end processing | 0.358678 | 0.445 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.358678 | 0.445 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.358678 | 0.445 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.358678 | 0.445 |
| R-HSA-69306 | DNA Replication | 0.360757 | 0.443 |
| R-HSA-1221632 | Meiotic synapsis | 0.363418 | 0.440 |
| R-HSA-418597 | G alpha (z) signalling events | 0.372793 | 0.429 |
| R-HSA-199991 | Membrane Trafficking | 0.373952 | 0.427 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.377429 | 0.423 |
| R-HSA-75893 | TNF signaling | 0.377429 | 0.423 |
| R-HSA-5578775 | Ion homeostasis | 0.377429 | 0.423 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.377429 | 0.423 |
| R-HSA-446728 | Cell junction organization | 0.378377 | 0.422 |
| R-HSA-112399 | IRS-mediated signalling | 0.382031 | 0.418 |
| R-HSA-5621480 | Dectin-2 family | 0.382031 | 0.418 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.386600 | 0.413 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.391135 | 0.408 |
| R-HSA-977443 | GABA receptor activation | 0.395636 | 0.403 |
| R-HSA-379724 | tRNA Aminoacylation | 0.395636 | 0.403 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.400105 | 0.398 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.400105 | 0.398 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.400105 | 0.398 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.404541 | 0.393 |
| R-HSA-9707616 | Heme signaling | 0.404541 | 0.393 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.408944 | 0.388 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.408944 | 0.388 |
| R-HSA-8848021 | Signaling by PTK6 | 0.408944 | 0.388 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.408944 | 0.388 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.408944 | 0.388 |
| R-HSA-373755 | Semaphorin interactions | 0.408944 | 0.388 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.413315 | 0.384 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.413315 | 0.384 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.415524 | 0.381 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.417654 | 0.379 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.417654 | 0.379 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.421962 | 0.375 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.426237 | 0.370 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.430482 | 0.366 |
| R-HSA-167172 | Transcription of the HIV genome | 0.430482 | 0.366 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.430482 | 0.366 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.438877 | 0.358 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.443028 | 0.354 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.443028 | 0.354 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.443028 | 0.354 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.447149 | 0.350 |
| R-HSA-8953854 | Metabolism of RNA | 0.447273 | 0.349 |
| R-HSA-69275 | G2/M Transition | 0.448259 | 0.348 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.451240 | 0.346 |
| R-HSA-4086398 | Ca2+ pathway | 0.451240 | 0.346 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.451240 | 0.346 |
| R-HSA-1500931 | Cell-Cell communication | 0.453132 | 0.344 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.453205 | 0.344 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.455301 | 0.342 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.455301 | 0.342 |
| R-HSA-983712 | Ion channel transport | 0.455669 | 0.341 |
| R-HSA-8852135 | Protein ubiquitination | 0.459332 | 0.338 |
| R-HSA-917937 | Iron uptake and transport | 0.459332 | 0.338 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.463023 | 0.334 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.463334 | 0.334 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.466533 | 0.331 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.467893 | 0.330 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.468830 | 0.329 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.471249 | 0.327 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.471249 | 0.327 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.475163 | 0.323 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.475163 | 0.323 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.479048 | 0.320 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.479048 | 0.320 |
| R-HSA-6806834 | Signaling by MET | 0.479048 | 0.320 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.482905 | 0.316 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.490533 | 0.309 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.490533 | 0.309 |
| R-HSA-162582 | Signal Transduction | 0.493247 | 0.307 |
| R-HSA-72172 | mRNA Splicing | 0.494211 | 0.306 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.494306 | 0.306 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.494306 | 0.306 |
| R-HSA-1500620 | Meiosis | 0.498050 | 0.303 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.501768 | 0.299 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.501768 | 0.299 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.501768 | 0.299 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.502162 | 0.299 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.505457 | 0.296 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.509120 | 0.293 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.514988 | 0.288 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.519948 | 0.284 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.530539 | 0.275 |
| R-HSA-8951664 | Neddylation | 0.533245 | 0.273 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.534018 | 0.272 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.537471 | 0.270 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.547678 | 0.261 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.547678 | 0.261 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.551031 | 0.259 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.551031 | 0.259 |
| R-HSA-422356 | Regulation of insulin secretion | 0.554359 | 0.256 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.560941 | 0.251 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.562087 | 0.250 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.564196 | 0.249 |
| R-HSA-157118 | Signaling by NOTCH | 0.574406 | 0.241 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.579071 | 0.237 |
| R-HSA-69239 | Synthesis of DNA | 0.586322 | 0.232 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.592436 | 0.227 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.592436 | 0.227 |
| R-HSA-168256 | Immune System | 0.599148 | 0.222 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.607333 | 0.217 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.610936 | 0.214 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.613139 | 0.212 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.616010 | 0.210 |
| R-HSA-416476 | G alpha (q) signalling events | 0.622576 | 0.206 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.623051 | 0.205 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.624498 | 0.204 |
| R-HSA-5693538 | Homology Directed Repair | 0.624498 | 0.204 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.627285 | 0.203 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.638232 | 0.195 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.638232 | 0.195 |
| R-HSA-194138 | Signaling by VEGF | 0.646232 | 0.190 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.648859 | 0.188 |
| R-HSA-69481 | G2/M Checkpoints | 0.651468 | 0.186 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.654056 | 0.184 |
| R-HSA-9675108 | Nervous system development | 0.655009 | 0.184 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.659177 | 0.181 |
| R-HSA-1474165 | Reproduction | 0.661710 | 0.179 |
| R-HSA-9843745 | Adipogenesis | 0.664223 | 0.178 |
| R-HSA-5576891 | Cardiac conduction | 0.664223 | 0.178 |
| R-HSA-9909396 | Circadian clock | 0.666718 | 0.176 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.678487 | 0.168 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.678920 | 0.168 |
| R-HSA-5173105 | O-linked glycosylation | 0.681307 | 0.167 |
| R-HSA-6798695 | Neutrophil degranulation | 0.689310 | 0.162 |
| R-HSA-1632852 | Macroautophagy | 0.690679 | 0.161 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.700077 | 0.155 |
| R-HSA-112316 | Neuronal System | 0.704042 | 0.152 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.706427 | 0.151 |
| R-HSA-166520 | Signaling by NTRKs | 0.708611 | 0.150 |
| R-HSA-9758941 | Gastrulation | 0.710778 | 0.148 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.719291 | 0.143 |
| R-HSA-73887 | Death Receptor Signaling | 0.721379 | 0.142 |
| R-HSA-1989781 | PPARA activates gene expression | 0.723453 | 0.141 |
| R-HSA-9612973 | Autophagy | 0.725511 | 0.139 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.727554 | 0.138 |
| R-HSA-392499 | Metabolism of proteins | 0.729339 | 0.137 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.729582 | 0.137 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.733593 | 0.135 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.733593 | 0.135 |
| R-HSA-109581 | Apoptosis | 0.737545 | 0.132 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.741439 | 0.130 |
| R-HSA-418555 | G alpha (s) signalling events | 0.756451 | 0.121 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.756451 | 0.121 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.760066 | 0.119 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.760066 | 0.119 |
| R-HSA-2559583 | Cellular Senescence | 0.772307 | 0.112 |
| R-HSA-3781865 | Diseases of glycosylation | 0.779022 | 0.108 |
| R-HSA-5617833 | Cilium Assembly | 0.788727 | 0.103 |
| R-HSA-422475 | Axon guidance | 0.792653 | 0.101 |
| R-HSA-9679506 | SARS-CoV Infections | 0.802388 | 0.096 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.806888 | 0.093 |
| R-HSA-5357801 | Programmed Cell Death | 0.812591 | 0.090 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.817601 | 0.087 |
| R-HSA-418594 | G alpha (i) signalling events | 0.827773 | 0.082 |
| R-HSA-212436 | Generic Transcription Pathway | 0.832428 | 0.080 |
| R-HSA-5668914 | Diseases of metabolism | 0.846611 | 0.072 |
| R-HSA-109582 | Hemostasis | 0.851031 | 0.070 |
| R-HSA-382551 | Transport of small molecules | 0.869056 | 0.061 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.883231 | 0.054 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.894117 | 0.049 |
| R-HSA-9658195 | Leishmania infection | 0.894117 | 0.049 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.894911 | 0.048 |
| R-HSA-1280218 | Adaptive Immune System | 0.901504 | 0.045 |
| R-HSA-195721 | Signaling by WNT | 0.906847 | 0.042 |
| R-HSA-8957322 | Metabolism of steroids | 0.923440 | 0.035 |
| R-HSA-1266738 | Developmental Biology | 0.927317 | 0.033 |
| R-HSA-388396 | GPCR downstream signalling | 0.936860 | 0.028 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.951375 | 0.022 |
| R-HSA-372790 | Signaling by GPCR | 0.960488 | 0.018 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.963833 | 0.016 |
| R-HSA-72766 | Translation | 0.965707 | 0.015 |
| R-HSA-9824446 | Viral Infection Pathways | 0.973599 | 0.012 |
| R-HSA-1643685 | Disease | 0.984983 | 0.007 |
| R-HSA-168249 | Innate Immune System | 0.991629 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.991920 | 0.004 |
| R-HSA-5663205 | Infectious disease | 0.996638 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999992 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
NLK |
0.825 | 0.326 | 1 | 0.892 |
CDK5 |
0.823 | 0.394 | 1 | 0.841 |
CDK19 |
0.823 | 0.350 | 1 | 0.829 |
CDK8 |
0.823 | 0.343 | 1 | 0.852 |
CDK18 |
0.822 | 0.374 | 1 | 0.790 |
CLK3 |
0.822 | 0.247 | 1 | 0.846 |
SRPK1 |
0.821 | 0.178 | -3 | 0.515 |
COT |
0.819 | 0.034 | 2 | 0.869 |
KIS |
0.818 | 0.263 | 1 | 0.861 |
CDK7 |
0.816 | 0.314 | 1 | 0.842 |
CDKL5 |
0.815 | 0.132 | -3 | 0.541 |
HIPK4 |
0.815 | 0.203 | 1 | 0.856 |
JNK2 |
0.815 | 0.377 | 1 | 0.814 |
PRKD1 |
0.815 | 0.123 | -3 | 0.603 |
ERK5 |
0.814 | 0.187 | 1 | 0.797 |
CDK3 |
0.814 | 0.394 | 1 | 0.759 |
CDKL1 |
0.813 | 0.099 | -3 | 0.538 |
CDK16 |
0.813 | 0.367 | 1 | 0.759 |
MTOR |
0.812 | 0.073 | 1 | 0.792 |
ICK |
0.812 | 0.206 | -3 | 0.572 |
CDK13 |
0.811 | 0.321 | 1 | 0.826 |
ULK2 |
0.811 | 0.009 | 2 | 0.799 |
CDK1 |
0.811 | 0.354 | 1 | 0.792 |
CDK17 |
0.810 | 0.342 | 1 | 0.750 |
P38A |
0.810 | 0.358 | 1 | 0.844 |
MST4 |
0.809 | 0.095 | 2 | 0.890 |
SRPK2 |
0.809 | 0.122 | -3 | 0.446 |
ERK1 |
0.809 | 0.344 | 1 | 0.807 |
JNK3 |
0.809 | 0.354 | 1 | 0.829 |
P38B |
0.809 | 0.362 | 1 | 0.795 |
HIPK2 |
0.808 | 0.304 | 1 | 0.801 |
DYRK2 |
0.808 | 0.278 | 1 | 0.844 |
PRPK |
0.807 | -0.032 | -1 | 0.764 |
P38G |
0.807 | 0.350 | 1 | 0.749 |
DSTYK |
0.807 | 0.006 | 2 | 0.893 |
CDK9 |
0.807 | 0.316 | 1 | 0.834 |
NDR2 |
0.806 | 0.019 | -3 | 0.545 |
PKCD |
0.806 | 0.085 | 2 | 0.824 |
CDK2 |
0.806 | 0.328 | 1 | 0.820 |
TBK1 |
0.806 | -0.025 | 1 | 0.716 |
NEK6 |
0.806 | 0.035 | -2 | 0.818 |
PKN3 |
0.805 | 0.026 | -3 | 0.545 |
CDK12 |
0.805 | 0.315 | 1 | 0.814 |
GCN2 |
0.804 | -0.105 | 2 | 0.818 |
WNK1 |
0.804 | 0.029 | -2 | 0.835 |
PRKD2 |
0.804 | 0.032 | -3 | 0.533 |
PIM3 |
0.804 | -0.016 | -3 | 0.547 |
HIPK3 |
0.804 | 0.283 | 1 | 0.867 |
NUAK2 |
0.804 | 0.028 | -3 | 0.551 |
HIPK1 |
0.803 | 0.272 | 1 | 0.858 |
CLK1 |
0.803 | 0.172 | -3 | 0.512 |
CDK14 |
0.803 | 0.325 | 1 | 0.821 |
P38D |
0.802 | 0.353 | 1 | 0.778 |
DYRK1A |
0.802 | 0.240 | 1 | 0.877 |
PKN2 |
0.802 | 0.034 | -3 | 0.557 |
NEK7 |
0.801 | -0.043 | -3 | 0.574 |
IKKE |
0.801 | -0.052 | 1 | 0.712 |
MLK2 |
0.801 | 0.069 | 2 | 0.855 |
SRPK3 |
0.801 | 0.107 | -3 | 0.473 |
RAF1 |
0.801 | -0.102 | 1 | 0.764 |
NDR1 |
0.801 | -0.023 | -3 | 0.549 |
PDHK1 |
0.800 | -0.078 | 1 | 0.799 |
PDHK4 |
0.800 | -0.163 | 1 | 0.790 |
MLK1 |
0.800 | -0.007 | 2 | 0.849 |
NEK9 |
0.799 | 0.016 | 2 | 0.863 |
MOS |
0.799 | -0.040 | 1 | 0.731 |
ERK2 |
0.799 | 0.298 | 1 | 0.822 |
RIPK3 |
0.798 | -0.042 | 3 | 0.774 |
CHAK2 |
0.798 | 0.008 | -1 | 0.713 |
ATR |
0.798 | -0.030 | 1 | 0.733 |
LATS2 |
0.798 | 0.023 | -5 | 0.806 |
BMPR2 |
0.798 | -0.121 | -2 | 0.842 |
P90RSK |
0.798 | -0.021 | -3 | 0.534 |
CDK10 |
0.798 | 0.306 | 1 | 0.812 |
NIK |
0.797 | -0.011 | -3 | 0.595 |
IRE1 |
0.797 | 0.023 | 1 | 0.721 |
CDC7 |
0.797 | -0.105 | 1 | 0.672 |
ULK1 |
0.797 | -0.064 | -3 | 0.562 |
RSK3 |
0.797 | -0.019 | -3 | 0.531 |
PKCB |
0.797 | 0.074 | 2 | 0.789 |
CAMK1B |
0.797 | -0.063 | -3 | 0.588 |
CDK6 |
0.797 | 0.349 | 1 | 0.819 |
TGFBR2 |
0.797 | -0.046 | -2 | 0.730 |
IKKB |
0.797 | -0.131 | -2 | 0.707 |
PRKD3 |
0.796 | 0.029 | -3 | 0.535 |
CAMK2D |
0.796 | 0.001 | -3 | 0.578 |
MARK4 |
0.796 | -0.020 | 4 | 0.780 |
RSK2 |
0.795 | -0.028 | -3 | 0.528 |
CLK4 |
0.795 | 0.112 | -3 | 0.511 |
MAPKAPK3 |
0.795 | -0.017 | -3 | 0.539 |
PIM1 |
0.794 | 0.002 | -3 | 0.495 |
NUAK1 |
0.794 | -0.008 | -3 | 0.523 |
PKCA |
0.794 | 0.064 | 2 | 0.774 |
MLK3 |
0.793 | 0.043 | 2 | 0.789 |
IRE2 |
0.793 | 0.022 | 2 | 0.763 |
PHKG1 |
0.792 | 0.002 | -3 | 0.547 |
TSSK1 |
0.792 | 0.016 | -3 | 0.592 |
CAMK2G |
0.792 | -0.097 | 2 | 0.788 |
BCKDK |
0.792 | -0.108 | -1 | 0.719 |
DYRK4 |
0.792 | 0.277 | 1 | 0.810 |
PKCG |
0.791 | 0.034 | 2 | 0.771 |
AMPKA1 |
0.791 | -0.040 | -3 | 0.569 |
CDK4 |
0.791 | 0.328 | 1 | 0.805 |
WNK3 |
0.791 | -0.151 | 1 | 0.758 |
MAK |
0.791 | 0.269 | -2 | 0.776 |
TSSK2 |
0.790 | 0.025 | -5 | 0.831 |
NEK2 |
0.790 | 0.025 | 2 | 0.838 |
CAMLCK |
0.790 | -0.061 | -2 | 0.780 |
MNK2 |
0.789 | -0.016 | -2 | 0.720 |
NIM1 |
0.789 | -0.039 | 3 | 0.770 |
PKCZ |
0.789 | 0.018 | 2 | 0.810 |
CLK2 |
0.789 | 0.158 | -3 | 0.501 |
SKMLCK |
0.788 | -0.065 | -2 | 0.796 |
PKR |
0.788 | 0.035 | 1 | 0.766 |
AMPKA2 |
0.788 | -0.037 | -3 | 0.542 |
DYRK1B |
0.787 | 0.241 | 1 | 0.814 |
DAPK2 |
0.787 | -0.085 | -3 | 0.593 |
PRP4 |
0.787 | 0.151 | -3 | 0.525 |
MASTL |
0.787 | -0.164 | -2 | 0.789 |
HUNK |
0.787 | -0.112 | 2 | 0.790 |
PKCH |
0.786 | 0.012 | 2 | 0.762 |
MELK |
0.785 | -0.052 | -3 | 0.554 |
IKKA |
0.785 | -0.090 | -2 | 0.712 |
ANKRD3 |
0.785 | -0.096 | 1 | 0.791 |
MLK4 |
0.785 | -0.004 | 2 | 0.773 |
MPSK1 |
0.785 | 0.136 | 1 | 0.753 |
P70S6KB |
0.785 | -0.071 | -3 | 0.531 |
LATS1 |
0.785 | 0.015 | -3 | 0.568 |
RIPK1 |
0.785 | -0.150 | 1 | 0.742 |
AKT2 |
0.784 | -0.001 | -3 | 0.458 |
AURC |
0.784 | -0.025 | -2 | 0.557 |
DYRK3 |
0.784 | 0.161 | 1 | 0.856 |
PKACG |
0.784 | -0.070 | -2 | 0.660 |
MAPKAPK2 |
0.784 | -0.034 | -3 | 0.487 |
SGK3 |
0.784 | 0.002 | -3 | 0.509 |
YSK4 |
0.784 | -0.027 | 1 | 0.723 |
ERK7 |
0.784 | 0.155 | 2 | 0.585 |
CHAK1 |
0.783 | -0.036 | 2 | 0.787 |
VRK2 |
0.783 | 0.030 | 1 | 0.820 |
PAK6 |
0.783 | -0.021 | -2 | 0.617 |
PAK3 |
0.783 | -0.070 | -2 | 0.717 |
PKCT |
0.782 | 0.026 | 2 | 0.773 |
MOK |
0.782 | 0.218 | 1 | 0.808 |
DLK |
0.782 | -0.156 | 1 | 0.753 |
IRAK4 |
0.781 | -0.010 | 1 | 0.737 |
QIK |
0.781 | -0.090 | -3 | 0.562 |
QSK |
0.781 | -0.042 | 4 | 0.755 |
MNK1 |
0.781 | -0.034 | -2 | 0.734 |
DNAPK |
0.780 | 0.002 | 1 | 0.666 |
JNK1 |
0.779 | 0.278 | 1 | 0.784 |
SIK |
0.779 | -0.058 | -3 | 0.505 |
GRK5 |
0.779 | -0.235 | -3 | 0.547 |
PINK1 |
0.779 | 0.006 | 1 | 0.828 |
PHKG2 |
0.779 | -0.013 | -3 | 0.540 |
MEKK1 |
0.779 | -0.010 | 1 | 0.775 |
PKG2 |
0.779 | -0.031 | -2 | 0.587 |
PAK1 |
0.778 | -0.076 | -2 | 0.714 |
TTBK2 |
0.778 | -0.163 | 2 | 0.702 |
MST3 |
0.778 | 0.066 | 2 | 0.867 |
PIM2 |
0.778 | -0.017 | -3 | 0.502 |
MEK1 |
0.778 | -0.093 | 2 | 0.851 |
MSK2 |
0.777 | -0.083 | -3 | 0.494 |
PKCI |
0.777 | 0.026 | 2 | 0.785 |
PLK4 |
0.777 | -0.031 | 2 | 0.591 |
ZAK |
0.777 | -0.014 | 1 | 0.747 |
HRI |
0.777 | -0.056 | -2 | 0.813 |
CAMK4 |
0.777 | -0.138 | -3 | 0.531 |
FAM20C |
0.776 | -0.014 | 2 | 0.575 |
RSK4 |
0.776 | -0.051 | -3 | 0.480 |
CHK1 |
0.776 | -0.052 | -3 | 0.548 |
SMG1 |
0.775 | -0.069 | 1 | 0.690 |
WNK4 |
0.775 | -0.050 | -2 | 0.827 |
PKACB |
0.775 | -0.037 | -2 | 0.580 |
AKT1 |
0.775 | -0.013 | -3 | 0.467 |
CAMK2A |
0.775 | -0.046 | 2 | 0.785 |
BRSK2 |
0.775 | -0.089 | -3 | 0.557 |
NEK5 |
0.774 | -0.014 | 1 | 0.755 |
AURB |
0.774 | -0.060 | -2 | 0.553 |
MEKK2 |
0.774 | -0.020 | 2 | 0.835 |
CAMK2B |
0.774 | -0.064 | 2 | 0.759 |
PLK1 |
0.774 | -0.098 | -2 | 0.776 |
DCAMKL1 |
0.774 | -0.036 | -3 | 0.532 |
HGK |
0.773 | 0.125 | 3 | 0.902 |
PERK |
0.773 | -0.082 | -2 | 0.793 |
PKN1 |
0.773 | 0.009 | -3 | 0.495 |
ATM |
0.772 | -0.104 | 1 | 0.664 |
MEKK6 |
0.772 | 0.092 | 1 | 0.735 |
BRAF |
0.772 | -0.042 | -4 | 0.766 |
MEK5 |
0.772 | -0.098 | 2 | 0.847 |
TLK2 |
0.772 | -0.085 | 1 | 0.728 |
GRK1 |
0.772 | -0.100 | -2 | 0.728 |
PKCE |
0.771 | 0.037 | 2 | 0.759 |
TAO3 |
0.771 | 0.013 | 1 | 0.750 |
SSTK |
0.771 | 0.009 | 4 | 0.759 |
MARK2 |
0.771 | -0.068 | 4 | 0.672 |
MARK3 |
0.770 | -0.065 | 4 | 0.708 |
MAPKAPK5 |
0.770 | -0.112 | -3 | 0.486 |
ALK4 |
0.770 | -0.127 | -2 | 0.753 |
GRK6 |
0.770 | -0.199 | 1 | 0.703 |
TNIK |
0.770 | 0.136 | 3 | 0.901 |
MINK |
0.769 | 0.102 | 1 | 0.753 |
BMPR1B |
0.769 | -0.061 | 1 | 0.614 |
MSK1 |
0.769 | -0.076 | -3 | 0.498 |
NEK4 |
0.768 | 0.030 | 1 | 0.748 |
GRK4 |
0.768 | -0.228 | -2 | 0.778 |
BRSK1 |
0.768 | -0.103 | -3 | 0.537 |
AKT3 |
0.767 | -0.003 | -3 | 0.416 |
TAO2 |
0.767 | 0.017 | 2 | 0.862 |
TGFBR1 |
0.767 | -0.100 | -2 | 0.730 |
SNRK |
0.767 | -0.166 | 2 | 0.657 |
MAP3K15 |
0.767 | 0.063 | 1 | 0.742 |
PAK2 |
0.767 | -0.134 | -2 | 0.693 |
MYLK4 |
0.766 | -0.102 | -2 | 0.689 |
MEKK3 |
0.766 | -0.152 | 1 | 0.744 |
NEK11 |
0.765 | -0.042 | 1 | 0.757 |
CAMK1G |
0.765 | -0.100 | -3 | 0.503 |
KHS1 |
0.765 | 0.108 | 1 | 0.748 |
DCAMKL2 |
0.765 | -0.060 | -3 | 0.558 |
PRKX |
0.765 | -0.045 | -3 | 0.419 |
P70S6K |
0.764 | -0.079 | -3 | 0.473 |
MARK1 |
0.764 | -0.108 | 4 | 0.736 |
ACVR2A |
0.763 | -0.111 | -2 | 0.734 |
EEF2K |
0.763 | 0.077 | 3 | 0.891 |
GRK7 |
0.763 | -0.078 | 1 | 0.652 |
PLK3 |
0.762 | -0.134 | 2 | 0.737 |
SMMLCK |
0.762 | -0.086 | -3 | 0.552 |
PDK1 |
0.762 | -0.020 | 1 | 0.772 |
PKACA |
0.762 | -0.052 | -2 | 0.528 |
LOK |
0.762 | 0.003 | -2 | 0.733 |
IRAK1 |
0.761 | -0.159 | -1 | 0.654 |
CK1G1 |
0.761 | -0.110 | -3 | 0.267 |
NEK1 |
0.761 | 0.017 | 1 | 0.742 |
LKB1 |
0.761 | -0.033 | -3 | 0.566 |
GCK |
0.761 | 0.011 | 1 | 0.743 |
CAMKK1 |
0.761 | -0.065 | -2 | 0.730 |
CK1E |
0.760 | -0.112 | -3 | 0.254 |
MST2 |
0.760 | -0.018 | 1 | 0.742 |
TLK1 |
0.760 | -0.134 | -2 | 0.781 |
NEK3 |
0.760 | 0.024 | 1 | 0.751 |
CHK2 |
0.760 | -0.036 | -3 | 0.430 |
GSK3A |
0.760 | 0.035 | 4 | 0.374 |
ACVR2B |
0.760 | -0.127 | -2 | 0.749 |
KHS2 |
0.760 | 0.088 | 1 | 0.754 |
YSK1 |
0.760 | 0.047 | 2 | 0.849 |
DRAK1 |
0.759 | -0.151 | 1 | 0.631 |
ALK2 |
0.759 | -0.133 | -2 | 0.734 |
SGK1 |
0.758 | -0.024 | -3 | 0.395 |
HPK1 |
0.758 | 0.021 | 1 | 0.735 |
GSK3B |
0.758 | -0.013 | 4 | 0.367 |
CAMK1D |
0.757 | -0.082 | -3 | 0.460 |
NEK8 |
0.757 | -0.128 | 2 | 0.832 |
AURA |
0.756 | -0.100 | -2 | 0.517 |
SBK |
0.756 | -0.000 | -3 | 0.384 |
GAK |
0.756 | -0.046 | 1 | 0.750 |
PAK5 |
0.756 | -0.092 | -2 | 0.548 |
CAMKK2 |
0.756 | -0.074 | -2 | 0.725 |
LRRK2 |
0.754 | -0.045 | 2 | 0.848 |
TTBK1 |
0.754 | -0.158 | 2 | 0.605 |
TAK1 |
0.754 | -0.043 | 1 | 0.766 |
BUB1 |
0.754 | 0.051 | -5 | 0.767 |
MRCKB |
0.753 | -0.049 | -3 | 0.487 |
PBK |
0.753 | 0.018 | 1 | 0.691 |
PASK |
0.752 | -0.098 | -3 | 0.547 |
CAMK1A |
0.752 | -0.052 | -3 | 0.445 |
PDHK3_TYR |
0.752 | 0.109 | 4 | 0.853 |
PAK4 |
0.752 | -0.084 | -2 | 0.553 |
MST1 |
0.751 | -0.041 | 1 | 0.737 |
ROCK2 |
0.750 | -0.044 | -3 | 0.519 |
BMPR1A |
0.750 | -0.109 | 1 | 0.602 |
VRK1 |
0.749 | -0.094 | 2 | 0.821 |
CK1D |
0.749 | -0.122 | -3 | 0.213 |
SLK |
0.749 | -0.064 | -2 | 0.673 |
MEK2 |
0.748 | -0.113 | 2 | 0.826 |
RIPK2 |
0.748 | -0.165 | 1 | 0.725 |
MRCKA |
0.747 | -0.075 | -3 | 0.493 |
DAPK3 |
0.747 | -0.104 | -3 | 0.526 |
LIMK2_TYR |
0.747 | 0.097 | -3 | 0.626 |
GRK2 |
0.747 | -0.174 | -2 | 0.648 |
HASPIN |
0.747 | 0.006 | -1 | 0.594 |
MYO3B |
0.746 | 0.056 | 2 | 0.852 |
PKMYT1_TYR |
0.746 | 0.096 | 3 | 0.834 |
TNNI3K_TYR |
0.745 | 0.152 | 1 | 0.798 |
DMPK1 |
0.745 | -0.027 | -3 | 0.498 |
MYO3A |
0.745 | 0.059 | 1 | 0.742 |
PKG1 |
0.744 | -0.070 | -2 | 0.498 |
TESK1_TYR |
0.743 | -0.036 | 3 | 0.865 |
CK1A2 |
0.743 | -0.138 | -3 | 0.212 |
TTK |
0.742 | -0.023 | -2 | 0.782 |
STK33 |
0.742 | -0.133 | 2 | 0.597 |
ASK1 |
0.741 | 0.015 | 1 | 0.730 |
TAO1 |
0.741 | -0.012 | 1 | 0.716 |
BIKE |
0.740 | 0.039 | 1 | 0.653 |
OSR1 |
0.740 | -0.026 | 2 | 0.843 |
ROS1 |
0.739 | 0.004 | 3 | 0.822 |
ROCK1 |
0.739 | -0.059 | -3 | 0.495 |
MAP2K4_TYR |
0.738 | -0.095 | -1 | 0.776 |
TYK2 |
0.738 | -0.038 | 1 | 0.755 |
JAK1 |
0.737 | 0.080 | 1 | 0.726 |
MAP2K7_TYR |
0.737 | -0.193 | 2 | 0.848 |
PDHK4_TYR |
0.736 | -0.092 | 2 | 0.873 |
JAK2 |
0.736 | -0.019 | 1 | 0.768 |
MAP2K6_TYR |
0.736 | -0.084 | -1 | 0.776 |
CRIK |
0.736 | -0.051 | -3 | 0.465 |
LIMK1_TYR |
0.736 | -0.058 | 2 | 0.852 |
DAPK1 |
0.736 | -0.128 | -3 | 0.505 |
RET |
0.735 | -0.093 | 1 | 0.755 |
CSF1R |
0.735 | -0.015 | 3 | 0.812 |
TYRO3 |
0.734 | -0.054 | 3 | 0.830 |
PINK1_TYR |
0.734 | -0.163 | 1 | 0.757 |
MST1R |
0.733 | -0.070 | 3 | 0.817 |
PLK2 |
0.733 | -0.130 | -3 | 0.504 |
AAK1 |
0.732 | 0.083 | 1 | 0.574 |
BMPR2_TYR |
0.732 | -0.090 | -1 | 0.741 |
EPHA6 |
0.732 | -0.023 | -1 | 0.708 |
NEK10_TYR |
0.731 | -0.008 | 1 | 0.664 |
PDHK1_TYR |
0.730 | -0.157 | -1 | 0.765 |
TNK1 |
0.730 | -0.023 | 3 | 0.795 |
GRK3 |
0.729 | -0.185 | -2 | 0.591 |
JAK3 |
0.729 | -0.060 | 1 | 0.727 |
DDR1 |
0.727 | -0.112 | 4 | 0.779 |
TNK2 |
0.727 | -0.032 | 3 | 0.764 |
EPHB4 |
0.725 | -0.097 | -1 | 0.689 |
ABL2 |
0.725 | -0.083 | -1 | 0.708 |
YES1 |
0.725 | -0.089 | -1 | 0.744 |
CK2A2 |
0.724 | -0.106 | 1 | 0.509 |
LCK |
0.724 | -0.039 | -1 | 0.711 |
ITK |
0.723 | -0.057 | -1 | 0.683 |
TXK |
0.723 | -0.037 | 1 | 0.660 |
FGR |
0.723 | -0.130 | 1 | 0.718 |
PDGFRB |
0.723 | -0.108 | 3 | 0.825 |
STLK3 |
0.722 | -0.097 | 1 | 0.717 |
HCK |
0.722 | -0.088 | -1 | 0.713 |
ABL1 |
0.721 | -0.097 | -1 | 0.707 |
INSRR |
0.720 | -0.124 | 3 | 0.779 |
FGFR1 |
0.720 | -0.086 | 3 | 0.777 |
BLK |
0.720 | -0.036 | -1 | 0.717 |
DDR2 |
0.719 | -0.025 | 3 | 0.765 |
KIT |
0.719 | -0.113 | 3 | 0.802 |
TEK |
0.719 | -0.106 | 3 | 0.772 |
PDGFRA |
0.718 | -0.129 | 3 | 0.828 |
FLT3 |
0.718 | -0.143 | 3 | 0.822 |
KDR |
0.718 | -0.109 | 3 | 0.777 |
AXL |
0.717 | -0.114 | 3 | 0.782 |
FGFR2 |
0.716 | -0.139 | 3 | 0.788 |
ALPHAK3 |
0.715 | -0.151 | -1 | 0.643 |
TEC |
0.714 | -0.096 | -1 | 0.634 |
FER |
0.714 | -0.216 | 1 | 0.712 |
CK2A1 |
0.713 | -0.119 | 1 | 0.485 |
BMX |
0.713 | -0.085 | -1 | 0.604 |
MET |
0.713 | -0.119 | 3 | 0.786 |
WEE1_TYR |
0.712 | -0.089 | -1 | 0.628 |
SRMS |
0.712 | -0.162 | 1 | 0.687 |
ALK |
0.712 | -0.137 | 3 | 0.755 |
BTK |
0.711 | -0.185 | -1 | 0.658 |
EPHB1 |
0.711 | -0.166 | 1 | 0.701 |
MERTK |
0.710 | -0.133 | 3 | 0.770 |
EPHB3 |
0.709 | -0.164 | -1 | 0.674 |
CK1A |
0.709 | -0.153 | -3 | 0.145 |
EPHA4 |
0.708 | -0.156 | 2 | 0.728 |
EPHB2 |
0.707 | -0.164 | -1 | 0.665 |
YANK3 |
0.707 | -0.132 | 2 | 0.367 |
EPHA1 |
0.706 | -0.125 | 3 | 0.778 |
LTK |
0.706 | -0.168 | 3 | 0.757 |
INSR |
0.706 | -0.152 | 3 | 0.759 |
FYN |
0.706 | -0.092 | -1 | 0.693 |
NTRK2 |
0.706 | -0.182 | 3 | 0.761 |
PTK6 |
0.705 | -0.207 | -1 | 0.627 |
FRK |
0.704 | -0.146 | -1 | 0.711 |
LYN |
0.703 | -0.139 | 3 | 0.732 |
FGFR3 |
0.703 | -0.168 | 3 | 0.766 |
NTRK1 |
0.702 | -0.228 | -1 | 0.704 |
FLT4 |
0.702 | -0.182 | 3 | 0.758 |
NTRK3 |
0.702 | -0.150 | -1 | 0.660 |
FLT1 |
0.701 | -0.186 | -1 | 0.672 |
EPHA7 |
0.700 | -0.149 | 2 | 0.734 |
ERBB2 |
0.699 | -0.218 | 1 | 0.683 |
PTK2B |
0.698 | -0.116 | -1 | 0.689 |
SRC |
0.697 | -0.125 | -1 | 0.696 |
MATK |
0.696 | -0.166 | -1 | 0.626 |
EPHA3 |
0.696 | -0.200 | 2 | 0.703 |
CSK |
0.692 | -0.178 | 2 | 0.741 |
EGFR |
0.690 | -0.150 | 1 | 0.595 |
MUSK |
0.690 | -0.143 | 1 | 0.572 |
FGFR4 |
0.689 | -0.160 | -1 | 0.632 |
CK1G3 |
0.689 | -0.160 | -3 | 0.109 |
EPHA8 |
0.688 | -0.177 | -1 | 0.647 |
EPHA5 |
0.686 | -0.201 | 2 | 0.710 |
IGF1R |
0.683 | -0.194 | 3 | 0.692 |
PTK2 |
0.678 | -0.137 | -1 | 0.634 |
YANK2 |
0.678 | -0.150 | 2 | 0.390 |
EPHA2 |
0.677 | -0.185 | -1 | 0.604 |
SYK |
0.676 | -0.170 | -1 | 0.619 |
ERBB4 |
0.675 | -0.144 | 1 | 0.573 |
FES |
0.669 | -0.196 | -1 | 0.586 |
ZAP70 |
0.666 | -0.124 | -1 | 0.571 |
CK1G2 |
0.658 | -0.176 | -3 | 0.186 |