Motif 933 (n=118)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WTJ2 | GIMAP1-GIMAP5 | S221 | ochoa | GIMAP1-GIMAP5 readthrough | None |
| A8K0Z3 | WASHC1 | S219 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MWX3 | WASH4P | S232 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| C4AMC7 | WASH3P | S217 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| O00425 | IGF2BP3 | S438 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O14737 | PDCD5 | S42 | ochoa | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | May function in the process of apoptosis. |
| O43423 | ANP32CP | S73 | ochoa | Putative uncharacterized protein ANP32CP (Acidic leucine-rich nuclear phosphoprotein 32 family member C) (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1) | None |
| O43426 | SYNJ1 | S830 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43752 | STX6 | S127 | ochoa | Syntaxin-6 | SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}. |
| O43815 | STRN | S190 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60279 | SUSD5 | S325 | ochoa | Sushi domain-containing protein 5 | None |
| O75369 | FLNB | S755 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75410 | TACC1 | S361 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O94979 | SEC31A | S397 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95140 | MFN2 | S27 | ochoa|psp | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:19889647, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). {ECO:0000250|UniProtKB:Q80U63, ECO:0000250|UniProtKB:Q8R500, ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:19889647, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:26085578, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:28114303, ECO:0000305}. |
| O95831 | AIFM1 | S118 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P04150 | NR3C1 | S305 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P05549 | TFAP2A | S185 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P06746 | POLB | S44 | psp | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed:10556592, PubMed:17526740, PubMed:9556598, PubMed:9572863, PubMed:9614142). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed:9614142). {ECO:0000269|PubMed:10556592, ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:17526740, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9556598, ECO:0000269|PubMed:9572863, ECO:0000269|PubMed:9614142}. |
| P06748 | NPM1 | S82 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P08684 | CYP3A4 | S478 | psp | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P11055 | MYH3 | S729 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11166 | SLC2A1 | S465 | ochoa | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) | Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:10227690, PubMed:10954735, PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:32860739). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P17809, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:10227690, ECO:0000269|PubMed:10954735, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:27078104, ECO:0000269|PubMed:32860739}. |
| P12532 | CKMT1A | S147 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P12882 | MYH1 | S732 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P13535 | MYH8 | S731 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14598 | NCF1 | S208 | psp | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P17540 | CKMT2 | S148 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P18206 | VCL | S290 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20929 | NEB | S1380 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P23458 | JAK1 | S537 | ochoa | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}. |
| P28290 | ITPRID2 | S92 | ochoa|psp | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P32926 | DSG3 | S877 | ochoa | Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}. |
| P35221 | CTNNA1 | S690 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P39687 | ANP32A | S77 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| P43003 | SLC1A3 | S512 | ochoa | Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, PubMed:7521911, PubMed:8123008). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}. |
| P48729 | CSNK1A1 | S311 | ochoa | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. |
| P49790 | NUP153 | S711 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50990 | CCT8 | S269 | ochoa | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51825 | AFF1 | S83 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P51955 | NEK2 | S368 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P52292 | KPNA2 | S305 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P52732 | KIF11 | S36 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P55196 | AFDN | S424 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P61978 | HNRNPK | S75 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P61978 | HNRNPK | S420 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P78527 | PRKDC | S3018 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q00653 | NFKB2 | S872 | ochoa|psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q00872 | MYBPC1 | S611 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q06187 | BTK | S323 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q06323 | PSME1 | S175 | ochoa | Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| Q12929 | EPS8 | S574 | ochoa|psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q12955 | ANK3 | S3355 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q14254 | FLOT2 | S405 | ochoa | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Q14678 | KANK1 | S330 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q14789 | GOLGB1 | S1133 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15022 | SUZ12 | S546 | ochoa|psp | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15527 | SURF2 | S59 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q16555 | DPYSL2 | S427 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q16649 | NFIL3 | S19 | ochoa | Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}. |
| Q3MIT2 | PUS10 | S79 | ochoa | tRNA pseudouridine synthase Pus10 (Hup10) (EC 5.4.99.25) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) | Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270, PubMed:33023933). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270, PubMed:33023933). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). Does not show tRNA pseudouridylate synthase activity in the nucleus (PubMed:33023933). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588). {ECO:0000269|PubMed:14527409, ECO:0000269|PubMed:19712588, ECO:0000269|PubMed:30530625, ECO:0000269|PubMed:31819270, ECO:0000269|PubMed:33023933}. |
| Q53EU6 | GPAT3 | S68 | ochoa | Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (hGPAT3) (Lung cancer metastasis-associated protein 1) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) (MAG-1) | Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427, ECO:0000269|PubMed:30846318}. |
| Q5TH69 | ARFGEF3 | S284 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q6VEQ5 | WASH2P | S219 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6ZU80 | CEP128 | S1073 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q7Z5K2 | WAPL | S202 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q86SQ0 | PHLDB2 | S294 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86Y01 | DTX1 | S195 | ochoa | E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
| Q8IVF2 | AHNAK2 | S4324 | ochoa | Protein AHNAK2 | None |
| Q8IZT6 | ASPM | S253 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8NHV4 | NEDD1 | S332 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TF71 | SLC16A10 | S268 | ochoa | Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) | Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}. |
| Q8WUY3 | PRUNE2 | S2348 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WWY3 | PRPF31 | S439 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q8WYP5 | AHCTF1 | S1914 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92540 | SMG7 | S510 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92609 | TBC1D5 | S700 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q96CW1 | AP2M1 | S236 | ochoa | AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) | Component of the adaptor protein complex 2 (AP-2) (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:16581796). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (PubMed:19033387). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:11877457). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (PubMed:11877457). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P84092, ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:12694563, ECO:0000269|PubMed:12952941, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:16581796, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:31104773}. |
| Q96EP5 | DAZAP1 | S20 | ochoa | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
| Q96F81 | DISP1 | S1380 | ochoa | Protein dispatched homolog 1 | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}. |
| Q96FT9 | IFT43 | S78 | ochoa | Intraflagellar transport protein 43 homolog | As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684). Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380). {ECO:0000269|PubMed:21378380, ECO:0000269|PubMed:28400947, ECO:0000269|PubMed:28973684}. |
| Q96JM2 | ZNF462 | S701 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q9BXF6 | RAB11FIP5 | S209 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXS6 | NUSAP1 | S363 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BYI3 | HYCC1 | S453 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9C0D5 | TANC1 | S1711 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H0K1 | SIK2 | S90 | psp | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H0U4 | RAB1B | S179 | ochoa | Ras-related protein Rab-1B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}. |
| Q9H8V3 | ECT2 | S40 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NQA3 | WASH6P | S201 | ochoa | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9NU22 | MDN1 | S5128 | ochoa | Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) | Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}. |
| Q9NYH9 | UTP6 | S204 | ochoa | U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
| Q9NZI8 | IGF2BP1 | S438 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
| Q9NZM3 | ITSN2 | S1046 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P2D1 | CHD7 | S2275 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2Y5 | UVRAG | S571 | ochoa|psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UEE9 | CFDP1 | S116 | ochoa | Craniofacial development protein 1 (Bucentaur) | May play a role during embryogenesis. {ECO:0000250}. |
| Q9UKL3 | CASP8AP2 | S1745 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | S734 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9Y2F5 | ICE1 | S546 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2U8 | LEMD3 | S180 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2W1 | THRAP3 | S211 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y616 | IRAK3 | S152 | ochoa | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}. |
| Q9Y623 | MYH4 | S732 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P17987 | TCP1 | S374 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P11142 | HSPA8 | Y183 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P34931 | HSPA1L | Y185 | Sugiyama | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P54652 | HSPA2 | Y184 | Sugiyama | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P13667 | PDIA4 | S126 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P14625 | HSP90B1 | S680 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P17066 | HSPA6 | Y185 | Sugiyama | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| Q15084 | PDIA6 | S375 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| P19525 | EIF2AK2 | S418 | Sugiyama | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P49768 | PSEN1 | S397 | GPS6 | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P55769 | SNU13 | S29 | Sugiyama | NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:10545122, PubMed:17412961, PubMed:28781166). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| P62333 | PSMC6 | S189 | Sugiyama | 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| Q8N3D4 | EHBP1L1 | S927 | Sugiyama | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q9BT78 | COPS4 | S340 | Sugiyama | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.551457e-08 | 7.809 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.182562e-07 | 6.927 |
| R-HSA-3371571 | HSF1-dependent transactivation | 8.733012e-08 | 7.059 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.076587e-07 | 6.968 |
| R-HSA-3371556 | Cellular response to heat stress | 5.387140e-07 | 6.269 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.141686e-05 | 4.503 |
| R-HSA-3371511 | HSF1 activation | 5.123185e-05 | 4.290 |
| R-HSA-390522 | Striated Muscle Contraction | 5.222530e-04 | 3.282 |
| R-HSA-2262752 | Cellular responses to stress | 4.764395e-04 | 3.322 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.641252e-04 | 3.063 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.028409e-03 | 2.988 |
| R-HSA-9833482 | PKR-mediated signaling | 1.329156e-03 | 2.876 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 3.134253e-03 | 2.504 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.166307e-03 | 2.499 |
| R-HSA-913531 | Interferon Signaling | 3.981093e-03 | 2.400 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 4.626926e-03 | 2.335 |
| R-HSA-9700645 | ALK mutants bind TKIs | 5.473960e-03 | 2.262 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.299690e-03 | 2.276 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 6.386450e-03 | 2.195 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 6.386450e-03 | 2.195 |
| R-HSA-418990 | Adherens junctions interactions | 6.297115e-03 | 2.201 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 8.743242e-03 | 2.058 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 8.402883e-03 | 2.076 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.465280e-03 | 2.072 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.465280e-03 | 2.072 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.066655e-02 | 1.972 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.214522e-02 | 1.916 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.277595e-02 | 1.894 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.277595e-02 | 1.894 |
| R-HSA-421270 | Cell-cell junction organization | 1.225097e-02 | 1.912 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.135007e-02 | 1.945 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.391524e-02 | 1.857 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.412512e-02 | 1.850 |
| R-HSA-5619043 | Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) | 1.797095e-02 | 1.745 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 2.683578e-02 | 1.571 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 4.432770e-02 | 1.353 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 4.432770e-02 | 1.353 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 6.150733e-02 | 1.211 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 6.150733e-02 | 1.211 |
| R-HSA-5619062 | Defective SLC1A3 causes episodic ataxia 6 (EA6) | 6.150733e-02 | 1.211 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 6.998177e-02 | 1.155 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 6.998177e-02 | 1.155 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 6.998177e-02 | 1.155 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 8.670332e-02 | 1.062 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 8.670332e-02 | 1.062 |
| R-HSA-196025 | Formation of annular gap junctions | 9.495177e-02 | 1.022 |
| R-HSA-9020958 | Interleukin-21 signaling | 1.031262e-01 | 0.987 |
| R-HSA-9613354 | Lipophagy | 1.031262e-01 | 0.987 |
| R-HSA-190873 | Gap junction degradation | 1.031262e-01 | 0.987 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.112274e-01 | 0.954 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.712798e-02 | 1.567 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.192558e-01 | 0.924 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.192558e-01 | 0.924 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.192558e-01 | 0.924 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.078030e-02 | 1.512 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.272123e-01 | 0.895 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.350973e-01 | 0.869 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.350973e-01 | 0.869 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.350973e-01 | 0.869 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.350973e-01 | 0.869 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.350973e-01 | 0.869 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.506557e-01 | 0.822 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.583304e-01 | 0.800 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 1.583304e-01 | 0.800 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.163080e-02 | 1.287 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.734737e-01 | 0.761 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.101585e-01 | 0.677 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.101585e-01 | 0.677 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.172990e-01 | 0.663 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.313883e-01 | 0.636 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.588157e-01 | 0.587 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.721625e-01 | 0.565 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.362335e-01 | 0.866 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.362335e-01 | 0.866 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.787462e-01 | 0.555 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.455047e-01 | 0.837 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.852707e-01 | 0.545 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.852707e-01 | 0.545 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.981444e-01 | 0.526 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.981444e-01 | 0.526 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.044946e-01 | 0.516 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.676083e-01 | 0.776 |
| R-HSA-380287 | Centrosome maturation | 1.740274e-01 | 0.759 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.198779e-01 | 0.658 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.294341e-01 | 0.888 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.599073e-01 | 0.585 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.265214e-01 | 0.645 |
| R-HSA-8854691 | Interleukin-20 family signaling | 2.313883e-01 | 0.636 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.429116e-01 | 0.845 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.495156e-02 | 1.347 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.427599e-02 | 1.129 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.350973e-01 | 0.869 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.532161e-01 | 0.597 |
| R-HSA-9834899 | Specification of the neural plate border | 2.040274e-02 | 1.690 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.272123e-01 | 0.895 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.243755e-01 | 0.649 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.165625e-01 | 0.664 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.031262e-01 | 0.987 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.734737e-01 | 0.761 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 8.410331e-02 | 1.075 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.863953e-02 | 1.232 |
| R-HSA-204005 | COPII-mediated vesicle transport | 3.463581e-02 | 1.460 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.655192e-01 | 0.576 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 5.393155e-02 | 1.268 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 1.429116e-01 | 0.845 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.393155e-02 | 1.268 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.618569e-02 | 1.791 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.721625e-01 | 0.565 |
| R-HSA-6783589 | Interleukin-6 family signaling | 2.383382e-01 | 0.623 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.429116e-01 | 0.845 |
| R-HSA-72172 | mRNA Splicing | 1.472488e-01 | 0.832 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.369038e-01 | 0.864 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.132751e-01 | 0.946 |
| R-HSA-164939 | Nef mediated downregulation of CD28 cell surface expression | 2.683578e-02 | 1.571 |
| R-HSA-8849473 | PTK6 Expression | 8.670332e-02 | 1.062 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 7.099304e-02 | 1.149 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.064308e-01 | 0.973 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.192558e-01 | 0.924 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.520513e-01 | 0.599 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 8.670332e-02 | 1.062 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.506557e-01 | 0.822 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.778818e-02 | 1.750 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.520513e-01 | 0.599 |
| R-HSA-8984722 | Interleukin-35 Signalling | 1.350973e-01 | 0.869 |
| R-HSA-437239 | Recycling pathway of L1 | 8.953886e-02 | 1.048 |
| R-HSA-525793 | Myogenesis | 2.520513e-01 | 0.599 |
| R-HSA-5635838 | Activation of SMO | 1.659362e-01 | 0.780 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.172990e-01 | 0.663 |
| R-HSA-8985947 | Interleukin-9 signaling | 9.495177e-02 | 1.022 |
| R-HSA-391251 | Protein folding | 2.365133e-01 | 0.626 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.809436e-01 | 0.742 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.580616e-01 | 0.801 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.370799e-02 | 1.625 |
| R-HSA-169131 | Inhibition of PKR | 1.797095e-02 | 1.745 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.295620e-02 | 1.276 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 6.998177e-02 | 1.155 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.031262e-01 | 0.987 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.112274e-01 | 0.954 |
| R-HSA-4839744 | Signaling by APC mutants | 1.192558e-01 | 0.924 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.893083e-02 | 1.539 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.272123e-01 | 0.895 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.272123e-01 | 0.895 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.272123e-01 | 0.895 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.350973e-01 | 0.869 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.350973e-01 | 0.869 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.583304e-01 | 0.800 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.179967e-02 | 1.662 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.383382e-01 | 0.623 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.852707e-01 | 0.545 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.917366e-01 | 0.535 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.291484e-01 | 0.640 |
| R-HSA-68877 | Mitotic Prometaphase | 1.278620e-01 | 0.893 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.461520e-02 | 1.461 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.883464e-01 | 0.725 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.370799e-02 | 1.625 |
| R-HSA-9020956 | Interleukin-27 signaling | 1.112274e-01 | 0.954 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 6.845879e-02 | 1.165 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.112274e-01 | 0.954 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.659362e-01 | 0.780 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 7.355754e-02 | 1.133 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 7.355754e-02 | 1.133 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.313883e-01 | 0.636 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.520513e-01 | 0.599 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.765433e-02 | 1.057 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.044946e-01 | 0.516 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.452257e-01 | 0.610 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.122392e-01 | 0.950 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.174070e-02 | 1.286 |
| R-HSA-5260271 | Diseases of Immune System | 6.845879e-02 | 1.165 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.845879e-02 | 1.165 |
| R-HSA-2424491 | DAP12 signaling | 2.787462e-01 | 0.555 |
| R-HSA-449147 | Signaling by Interleukins | 1.340161e-01 | 0.873 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.125734e-02 | 1.672 |
| R-HSA-5653890 | Lactose synthesis | 7.838021e-02 | 1.106 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 9.495177e-02 | 1.022 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 9.495177e-02 | 1.022 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 9.495177e-02 | 1.022 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.031262e-01 | 0.987 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.112274e-01 | 0.954 |
| R-HSA-9754706 | Atorvastatin ADME | 1.659362e-01 | 0.780 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.883464e-01 | 0.725 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.151740e-01 | 0.939 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.767770e-02 | 1.424 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.917366e-01 | 0.535 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.033517e-01 | 0.692 |
| R-HSA-68886 | M Phase | 3.125863e-02 | 1.505 |
| R-HSA-5617833 | Cilium Assembly | 4.256116e-02 | 1.371 |
| R-HSA-199991 | Membrane Trafficking | 1.918770e-02 | 1.717 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.181284e-01 | 0.928 |
| R-HSA-9663891 | Selective autophagy | 2.198779e-01 | 0.658 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.031262e-01 | 0.987 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.350973e-01 | 0.869 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 6.595554e-02 | 1.181 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 6.595554e-02 | 1.181 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.064308e-01 | 0.973 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.588157e-01 | 0.587 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.896104e-02 | 1.409 |
| R-HSA-68882 | Mitotic Anaphase | 1.676999e-01 | 0.775 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.042968e-02 | 1.219 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.694485e-01 | 0.771 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.837287e-01 | 0.736 |
| R-HSA-68875 | Mitotic Prophase | 1.230449e-01 | 0.910 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.772519e-01 | 0.751 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.262981e-01 | 0.899 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.753452e-02 | 1.240 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.112274e-01 | 0.954 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.362335e-01 | 0.866 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.852707e-01 | 0.545 |
| R-HSA-9612973 | Autophagy | 2.102735e-01 | 0.677 |
| R-HSA-373760 | L1CAM interactions | 3.132828e-02 | 1.504 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.434830e-02 | 1.614 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.210666e-01 | 0.917 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.210666e-01 | 0.917 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.270368e-01 | 0.896 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.290501e-01 | 0.889 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.047923e-01 | 0.516 |
| R-HSA-9907900 | Proteasome assembly | 8.142515e-02 | 1.089 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.612323e-01 | 0.793 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.612323e-01 | 0.793 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.270368e-01 | 0.896 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.031262e-01 | 0.987 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.272123e-01 | 0.895 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 8.953886e-02 | 1.048 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.455047e-01 | 0.837 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.902398e-01 | 0.721 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 6.150733e-02 | 1.211 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 6.998177e-02 | 1.155 |
| R-HSA-447041 | CHL1 interactions | 8.670332e-02 | 1.062 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 9.495177e-02 | 1.022 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.031262e-01 | 0.987 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.031262e-01 | 0.987 |
| R-HSA-448706 | Interleukin-1 processing | 1.031262e-01 | 0.987 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.200909e-02 | 1.657 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.192558e-01 | 0.924 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.583304e-01 | 0.800 |
| R-HSA-9766229 | Degradation of CDH1 | 9.507547e-02 | 1.022 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.470746e-02 | 1.262 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.787462e-01 | 0.555 |
| R-HSA-397795 | G-protein beta:gamma signalling | 2.981444e-01 | 0.526 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.044946e-01 | 0.516 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.044946e-01 | 0.516 |
| R-HSA-168256 | Immune System | 1.300030e-01 | 0.886 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.689101e-02 | 1.433 |
| R-HSA-8953854 | Metabolism of RNA | 1.553676e-01 | 0.809 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.612323e-01 | 0.793 |
| R-HSA-1632852 | Macroautophagy | 1.737273e-01 | 0.760 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.666009e-01 | 0.574 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.971074e-01 | 0.705 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.809436e-01 | 0.742 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.883464e-01 | 0.725 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.000635e-01 | 0.699 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.532161e-01 | 0.597 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.301300e-01 | 0.886 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.654181e-01 | 0.781 |
| R-HSA-69275 | G2/M Transition | 2.848844e-01 | 0.545 |
| R-HSA-71288 | Creatine metabolism | 2.200909e-02 | 1.657 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.537273e-02 | 1.596 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.495156e-02 | 1.347 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.883464e-01 | 0.725 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.883464e-01 | 0.725 |
| R-HSA-189200 | Cellular hexose transport | 2.243755e-01 | 0.649 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.243755e-01 | 0.649 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.852707e-01 | 0.545 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.759084e-02 | 1.170 |
| R-HSA-4086400 | PCP/CE pathway | 1.837287e-01 | 0.736 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.897990e-01 | 0.538 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.615400e-02 | 1.251 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.078017e-02 | 1.512 |
| R-HSA-1640170 | Cell Cycle | 3.408135e-02 | 1.467 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.917753e-01 | 0.717 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.459137e-01 | 0.609 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.644147e-01 | 0.784 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.112274e-01 | 0.954 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.101585e-01 | 0.677 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.732914e-02 | 1.563 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.981444e-01 | 0.526 |
| R-HSA-397014 | Muscle contraction | 6.109884e-02 | 1.214 |
| R-HSA-8964038 | LDL clearance | 2.243755e-01 | 0.649 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.013630e-02 | 1.300 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.112274e-01 | 0.954 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.506557e-01 | 0.822 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.506557e-01 | 0.822 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.583304e-01 | 0.800 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 1.734737e-01 | 0.761 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 2.101585e-01 | 0.677 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.172990e-01 | 0.663 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.721625e-01 | 0.565 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.044946e-01 | 0.516 |
| R-HSA-446728 | Cell junction organization | 1.953168e-02 | 1.709 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.243755e-01 | 0.649 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.883464e-01 | 0.725 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.520513e-01 | 0.599 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.644147e-01 | 0.784 |
| R-HSA-9758941 | Gastrulation | 1.940645e-01 | 0.712 |
| R-HSA-1500931 | Cell-Cell communication | 3.426806e-02 | 1.465 |
| R-HSA-168255 | Influenza Infection | 2.677482e-01 | 0.572 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.676083e-01 | 0.776 |
| R-HSA-597592 | Post-translational protein modification | 5.025320e-02 | 1.299 |
| R-HSA-162906 | HIV Infection | 1.872801e-01 | 0.728 |
| R-HSA-8876725 | Protein methylation | 1.583304e-01 | 0.800 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 2.101585e-01 | 0.677 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.981444e-01 | 0.526 |
| R-HSA-8939211 | ESR-mediated signaling | 8.570168e-02 | 1.067 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.495177e-02 | 1.022 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.708127e-01 | 0.767 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.732945e-01 | 0.563 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.074021e-01 | 0.969 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.247424e-01 | 0.904 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 7.099304e-02 | 1.149 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.162196e-02 | 1.381 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.580616e-01 | 0.801 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.781930e-01 | 0.749 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.252394e-02 | 1.083 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.981444e-01 | 0.526 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 9.291640e-02 | 1.032 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.966923e-01 | 0.528 |
| R-HSA-112310 | Neurotransmitter release cycle | 2.265214e-01 | 0.645 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.580616e-01 | 0.801 |
| R-HSA-9018682 | Biosynthesis of maresins | 2.313883e-01 | 0.636 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.066461e-01 | 0.685 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.890963e-01 | 0.723 |
| R-HSA-9833110 | RSV-host interactions | 2.833304e-01 | 0.548 |
| R-HSA-9824446 | Viral Infection Pathways | 1.591823e-01 | 0.798 |
| R-HSA-9694631 | Maturation of nucleoprotein | 1.956828e-01 | 0.708 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.243755e-01 | 0.649 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 2.520513e-01 | 0.599 |
| R-HSA-9757110 | Prednisone ADME | 2.655192e-01 | 0.576 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.009728e-01 | 0.697 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.681657e-01 | 0.572 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.143540e-02 | 1.289 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.632539e-01 | 0.580 |
| R-HSA-449836 | Other interleukin signaling | 1.956828e-01 | 0.708 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.956828e-01 | 0.708 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 1.486241e-01 | 0.828 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.956828e-01 | 0.708 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.981444e-01 | 0.526 |
| R-HSA-5619102 | SLC transporter disorders | 2.363090e-01 | 0.627 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.246066e-01 | 0.649 |
| R-HSA-9679506 | SARS-CoV Infections | 3.770576e-02 | 1.424 |
| R-HSA-622312 | Inflammasomes | 2.655192e-01 | 0.576 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.365133e-01 | 0.626 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.612323e-01 | 0.793 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.883464e-01 | 0.725 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.443446e-01 | 0.612 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.010210e-01 | 0.996 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.648955e-01 | 0.783 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.243755e-01 | 0.649 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.423995e-01 | 0.846 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.917366e-01 | 0.535 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.100183e-01 | 0.509 |
| R-HSA-5205647 | Mitophagy | 3.107878e-01 | 0.508 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.107878e-01 | 0.508 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.107878e-01 | 0.508 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.107878e-01 | 0.508 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.107878e-01 | 0.508 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.170244e-01 | 0.499 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.170244e-01 | 0.499 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.170244e-01 | 0.499 |
| R-HSA-169911 | Regulation of Apoptosis | 3.170244e-01 | 0.499 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.170244e-01 | 0.499 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.193930e-01 | 0.496 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.199805e-01 | 0.495 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.232049e-01 | 0.491 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.232049e-01 | 0.491 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.232049e-01 | 0.491 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.232049e-01 | 0.491 |
| R-HSA-111933 | Calmodulin induced events | 3.232049e-01 | 0.491 |
| R-HSA-111997 | CaM pathway | 3.232049e-01 | 0.491 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.266034e-01 | 0.486 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.293299e-01 | 0.482 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.293299e-01 | 0.482 |
| R-HSA-4641258 | Degradation of DVL | 3.293299e-01 | 0.482 |
| R-HSA-4641257 | Degradation of AXIN | 3.293299e-01 | 0.482 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.293299e-01 | 0.482 |
| R-HSA-5357801 | Programmed Cell Death | 3.342190e-01 | 0.476 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.353998e-01 | 0.474 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.353998e-01 | 0.474 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.397976e-01 | 0.469 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.414152e-01 | 0.467 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.414152e-01 | 0.467 |
| R-HSA-69541 | Stabilization of p53 | 3.414152e-01 | 0.467 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.414152e-01 | 0.467 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.414152e-01 | 0.467 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.463659e-01 | 0.460 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.473765e-01 | 0.459 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.473765e-01 | 0.459 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.473765e-01 | 0.459 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.473765e-01 | 0.459 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.473765e-01 | 0.459 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.473765e-01 | 0.459 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.532842e-01 | 0.452 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.532842e-01 | 0.452 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.532842e-01 | 0.452 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 3.532842e-01 | 0.452 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.532842e-01 | 0.452 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.532842e-01 | 0.452 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.532842e-01 | 0.452 |
| R-HSA-392499 | Metabolism of proteins | 3.582866e-01 | 0.446 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.591388e-01 | 0.445 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.591388e-01 | 0.445 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.591388e-01 | 0.445 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.591388e-01 | 0.445 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 3.591388e-01 | 0.445 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.591388e-01 | 0.445 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.591388e-01 | 0.445 |
| R-HSA-194138 | Signaling by VEGF | 3.626912e-01 | 0.440 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.649407e-01 | 0.438 |
| R-HSA-111996 | Ca-dependent events | 3.649407e-01 | 0.438 |
| R-HSA-9710421 | Defective pyroptosis | 3.706905e-01 | 0.431 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.706905e-01 | 0.431 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.744229e-01 | 0.427 |
| R-HSA-1280218 | Adaptive Immune System | 3.747952e-01 | 0.426 |
| R-HSA-190828 | Gap junction trafficking | 3.763886e-01 | 0.424 |
| R-HSA-2172127 | DAP12 interactions | 3.763886e-01 | 0.424 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.763886e-01 | 0.424 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.776216e-01 | 0.423 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.820354e-01 | 0.418 |
| R-HSA-774815 | Nucleosome assembly | 3.820354e-01 | 0.418 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.820354e-01 | 0.418 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.820354e-01 | 0.418 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.820354e-01 | 0.418 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.820354e-01 | 0.418 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.820354e-01 | 0.418 |
| R-HSA-9824272 | Somitogenesis | 3.820354e-01 | 0.418 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.876314e-01 | 0.412 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.876314e-01 | 0.412 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.876314e-01 | 0.412 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.876314e-01 | 0.412 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.876314e-01 | 0.412 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.876314e-01 | 0.412 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.876314e-01 | 0.412 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.876314e-01 | 0.412 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.876314e-01 | 0.412 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.876314e-01 | 0.412 |
| R-HSA-75153 | Apoptotic execution phase | 3.876314e-01 | 0.412 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.884869e-01 | 0.411 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.931772e-01 | 0.405 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.931772e-01 | 0.405 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.931772e-01 | 0.405 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.986730e-01 | 0.399 |
| R-HSA-5620924 | Intraflagellar transport | 3.986730e-01 | 0.399 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.986730e-01 | 0.399 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.041194e-01 | 0.393 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.041194e-01 | 0.393 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.041194e-01 | 0.393 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.043782e-01 | 0.393 |
| R-HSA-422475 | Axon guidance | 4.075360e-01 | 0.390 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.095168e-01 | 0.388 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.106804e-01 | 0.386 |
| R-HSA-6807070 | PTEN Regulation | 4.138195e-01 | 0.383 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.148656e-01 | 0.382 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.148656e-01 | 0.382 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.148656e-01 | 0.382 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.164138e-01 | 0.380 |
| R-HSA-9664407 | Parasite infection | 4.169503e-01 | 0.380 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.169503e-01 | 0.380 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.169503e-01 | 0.380 |
| R-HSA-157118 | Signaling by NOTCH | 4.198659e-01 | 0.377 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.200728e-01 | 0.377 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.201663e-01 | 0.377 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.201663e-01 | 0.377 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.201663e-01 | 0.377 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.201663e-01 | 0.377 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.201663e-01 | 0.377 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.201663e-01 | 0.377 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.254194e-01 | 0.371 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.254194e-01 | 0.371 |
| R-HSA-1221632 | Meiotic synapsis | 4.254194e-01 | 0.371 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.254194e-01 | 0.371 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.265465e-01 | 0.370 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.306251e-01 | 0.366 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.357840e-01 | 0.361 |
| R-HSA-6798695 | Neutrophil degranulation | 4.370601e-01 | 0.359 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.408965e-01 | 0.356 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.408965e-01 | 0.356 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.408965e-01 | 0.356 |
| R-HSA-9609646 | HCMV Infection | 4.437579e-01 | 0.353 |
| R-HSA-69242 | S Phase | 4.447411e-01 | 0.352 |
| R-HSA-1483166 | Synthesis of PA | 4.459630e-01 | 0.351 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.459630e-01 | 0.351 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.509839e-01 | 0.346 |
| R-HSA-168249 | Innate Immune System | 4.526097e-01 | 0.344 |
| R-HSA-73894 | DNA Repair | 4.526768e-01 | 0.344 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.559596e-01 | 0.341 |
| R-HSA-191859 | snRNP Assembly | 4.559596e-01 | 0.341 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.559596e-01 | 0.341 |
| R-HSA-112316 | Neuronal System | 4.565186e-01 | 0.341 |
| R-HSA-212436 | Generic Transcription Pathway | 4.586586e-01 | 0.339 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.598636e-01 | 0.337 |
| R-HSA-8873719 | RAB geranylgeranylation | 4.608905e-01 | 0.336 |
| R-HSA-983189 | Kinesins | 4.608905e-01 | 0.336 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.608905e-01 | 0.336 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.608905e-01 | 0.336 |
| R-HSA-351202 | Metabolism of polyamines | 4.608905e-01 | 0.336 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.608905e-01 | 0.336 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.608905e-01 | 0.336 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.608905e-01 | 0.336 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.608905e-01 | 0.336 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.608905e-01 | 0.336 |
| R-HSA-73887 | Death Receptor Signaling | 4.628596e-01 | 0.335 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.657770e-01 | 0.332 |
| R-HSA-112043 | PLC beta mediated events | 4.657770e-01 | 0.332 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.657770e-01 | 0.332 |
| R-HSA-9675108 | Nervous system development | 4.669748e-01 | 0.331 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.706195e-01 | 0.327 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.706195e-01 | 0.327 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.706195e-01 | 0.327 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.706195e-01 | 0.327 |
| R-HSA-9610379 | HCMV Late Events | 4.717897e-01 | 0.326 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.747468e-01 | 0.324 |
| R-HSA-373755 | Semaphorin interactions | 4.754184e-01 | 0.323 |
| R-HSA-8848021 | Signaling by PTK6 | 4.754184e-01 | 0.323 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.754184e-01 | 0.323 |
| R-HSA-211981 | Xenobiotics | 4.801741e-01 | 0.319 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.801741e-01 | 0.319 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.848870e-01 | 0.314 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.848870e-01 | 0.314 |
| R-HSA-109581 | Apoptosis | 4.864753e-01 | 0.313 |
| R-HSA-5663205 | Infectious disease | 4.881897e-01 | 0.311 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.911124e-01 | 0.309 |
| R-HSA-112040 | G-protein mediated events | 4.941859e-01 | 0.306 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.941859e-01 | 0.306 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.987726e-01 | 0.302 |
| R-HSA-5218859 | Regulated Necrosis | 4.987726e-01 | 0.302 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.078224e-01 | 0.294 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.078224e-01 | 0.294 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.122653e-01 | 0.291 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.150785e-01 | 0.288 |
| R-HSA-9658195 | Leishmania infection | 5.151388e-01 | 0.288 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.151388e-01 | 0.288 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.167100e-01 | 0.287 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.167100e-01 | 0.287 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.206730e-01 | 0.283 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.210938e-01 | 0.283 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.210938e-01 | 0.283 |
| R-HSA-9749641 | Aspirin ADME | 5.210938e-01 | 0.283 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.234542e-01 | 0.281 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 5.254382e-01 | 0.279 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.254382e-01 | 0.279 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.262246e-01 | 0.279 |
| R-HSA-8852135 | Protein ubiquitination | 5.297433e-01 | 0.276 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.297433e-01 | 0.276 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.327762e-01 | 0.273 |
| R-HSA-5689603 | UCH proteinases | 5.340097e-01 | 0.272 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.382377e-01 | 0.269 |
| R-HSA-2559583 | Cellular Senescence | 5.399146e-01 | 0.268 |
| R-HSA-6783783 | Interleukin-10 signaling | 5.424276e-01 | 0.266 |
| R-HSA-5619084 | ABC transporter disorders | 5.424276e-01 | 0.266 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.457687e-01 | 0.263 |
| R-HSA-9659379 | Sensory processing of sound | 5.465796e-01 | 0.262 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.479139e-01 | 0.261 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.479978e-01 | 0.261 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.506943e-01 | 0.259 |
| R-HSA-195721 | Signaling by WNT | 5.521867e-01 | 0.258 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 5.547719e-01 | 0.256 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.588127e-01 | 0.253 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.612496e-01 | 0.251 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.667855e-01 | 0.247 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.667855e-01 | 0.247 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.707180e-01 | 0.244 |
| R-HSA-1500620 | Meiosis | 5.707180e-01 | 0.244 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.707180e-01 | 0.244 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.746151e-01 | 0.241 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.746151e-01 | 0.241 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.746151e-01 | 0.241 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.784770e-01 | 0.238 |
| R-HSA-9609690 | HCMV Early Events | 5.818753e-01 | 0.235 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.823041e-01 | 0.235 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.860967e-01 | 0.232 |
| R-HSA-73884 | Base Excision Repair | 5.935796e-01 | 0.227 |
| R-HSA-202424 | Downstream TCR signaling | 5.935796e-01 | 0.227 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.993363e-01 | 0.222 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.045528e-01 | 0.219 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.045528e-01 | 0.219 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.081447e-01 | 0.216 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.081447e-01 | 0.216 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.117042e-01 | 0.213 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.152317e-01 | 0.211 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.187272e-01 | 0.209 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.221913e-01 | 0.206 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.233287e-01 | 0.205 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.256241e-01 | 0.204 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.290259e-01 | 0.201 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.290259e-01 | 0.201 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.290259e-01 | 0.201 |
| R-HSA-422356 | Regulation of insulin secretion | 6.290259e-01 | 0.201 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.323970e-01 | 0.199 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.357377e-01 | 0.197 |
| R-HSA-70171 | Glycolysis | 6.357377e-01 | 0.197 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.357377e-01 | 0.197 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.390482e-01 | 0.194 |
| R-HSA-74160 | Gene expression (Transcription) | 6.407332e-01 | 0.193 |
| R-HSA-1483255 | PI Metabolism | 6.423288e-01 | 0.192 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.423288e-01 | 0.192 |
| R-HSA-8951664 | Neddylation | 6.439680e-01 | 0.191 |
| R-HSA-111885 | Opioid Signalling | 6.488015e-01 | 0.188 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.488015e-01 | 0.188 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.519941e-01 | 0.186 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.519941e-01 | 0.186 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.551579e-01 | 0.184 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.551579e-01 | 0.184 |
| R-HSA-69239 | Synthesis of DNA | 6.614000e-01 | 0.180 |
| R-HSA-211000 | Gene Silencing by RNA | 6.614000e-01 | 0.180 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.644788e-01 | 0.178 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.675298e-01 | 0.176 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.675298e-01 | 0.176 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.675298e-01 | 0.176 |
| R-HSA-72312 | rRNA processing | 6.679791e-01 | 0.175 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.705533e-01 | 0.174 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.705533e-01 | 0.174 |
| R-HSA-202403 | TCR signaling | 6.705533e-01 | 0.174 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.722028e-01 | 0.172 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.765186e-01 | 0.170 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.765186e-01 | 0.170 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.794608e-01 | 0.168 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.823765e-01 | 0.166 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.881291e-01 | 0.162 |
| R-HSA-1643685 | Disease | 6.905411e-01 | 0.161 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.909665e-01 | 0.161 |
| R-HSA-70326 | Glucose metabolism | 6.965646e-01 | 0.157 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.965646e-01 | 0.157 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.993257e-01 | 0.155 |
| R-HSA-4839726 | Chromatin organization | 7.025145e-01 | 0.153 |
| R-HSA-73886 | Chromosome Maintenance | 7.074604e-01 | 0.150 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.074604e-01 | 0.150 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.127616e-01 | 0.147 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.127616e-01 | 0.147 |
| R-HSA-5688426 | Deubiquitination | 7.139765e-01 | 0.146 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.153764e-01 | 0.145 |
| R-HSA-69206 | G1/S Transition | 7.205351e-01 | 0.142 |
| R-HSA-114608 | Platelet degranulation | 7.256010e-01 | 0.139 |
| R-HSA-69481 | G2/M Checkpoints | 7.256010e-01 | 0.139 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.280997e-01 | 0.138 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.286857e-01 | 0.137 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.330294e-01 | 0.135 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.332753e-01 | 0.135 |
| R-HSA-1474165 | Reproduction | 7.354608e-01 | 0.133 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.375524e-01 | 0.132 |
| R-HSA-9843745 | Adipogenesis | 7.378703e-01 | 0.132 |
| R-HSA-9909396 | Circadian clock | 7.402579e-01 | 0.131 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.402579e-01 | 0.131 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.426240e-01 | 0.129 |
| R-HSA-162582 | Signal Transduction | 7.426850e-01 | 0.129 |
| R-HSA-163685 | Integration of energy metabolism | 7.518761e-01 | 0.124 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.563775e-01 | 0.121 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.672793e-01 | 0.115 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 7.694008e-01 | 0.114 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.715031e-01 | 0.113 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.756508e-01 | 0.110 |
| R-HSA-166520 | Signaling by NTRKs | 7.797237e-01 | 0.108 |
| R-HSA-1483257 | Phospholipid metabolism | 7.812872e-01 | 0.107 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.837231e-01 | 0.106 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.837231e-01 | 0.106 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.856957e-01 | 0.105 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.876504e-01 | 0.104 |
| R-HSA-69306 | DNA Replication | 7.895874e-01 | 0.103 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.934090e-01 | 0.101 |
| R-HSA-1989781 | PPARA activates gene expression | 7.934090e-01 | 0.101 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.971615e-01 | 0.098 |
| R-HSA-162587 | HIV Life Cycle | 7.971615e-01 | 0.098 |
| R-HSA-877300 | Interferon gamma signaling | 8.008464e-01 | 0.096 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.026639e-01 | 0.095 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.149329e-01 | 0.089 |
| R-HSA-72306 | tRNA processing | 8.216004e-01 | 0.085 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.304146e-01 | 0.081 |
| R-HSA-1266738 | Developmental Biology | 8.657237e-01 | 0.063 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.682430e-01 | 0.061 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.682430e-01 | 0.061 |
| R-HSA-6805567 | Keratinization | 8.730007e-01 | 0.059 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.809198e-01 | 0.055 |
| R-HSA-9748784 | Drug ADME | 8.862741e-01 | 0.052 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.943479e-01 | 0.048 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.981687e-01 | 0.047 |
| R-HSA-416476 | G alpha (q) signalling events | 9.255703e-01 | 0.034 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.318260e-01 | 0.031 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.320190e-01 | 0.031 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.321343e-01 | 0.031 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.345959e-01 | 0.029 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.369688e-01 | 0.028 |
| R-HSA-382551 | Transport of small molecules | 9.529100e-01 | 0.021 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.568664e-01 | 0.019 |
| R-HSA-1474244 | Extracellular matrix organization | 9.599483e-01 | 0.018 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.705120e-01 | 0.013 |
| R-HSA-388396 | GPCR downstream signalling | 9.771208e-01 | 0.010 |
| R-HSA-109582 | Hemostasis | 9.787203e-01 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 9.804156e-01 | 0.009 |
| R-HSA-72766 | Translation | 9.840465e-01 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 9.875687e-01 | 0.005 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.886012e-01 | 0.005 |
| R-HSA-211859 | Biological oxidations | 9.933788e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.996014e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999930e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.814 | 0.052 | 2 | 0.836 |
DSTYK |
0.808 | 0.104 | 2 | 0.820 |
ULK2 |
0.806 | 0.068 | 2 | 0.772 |
NEK6 |
0.805 | 0.113 | -2 | 0.833 |
NEK7 |
0.803 | 0.097 | -3 | 0.798 |
CDC7 |
0.801 | 0.027 | 1 | 0.780 |
PRPK |
0.801 | -0.027 | -1 | 0.637 |
PIM3 |
0.800 | 0.028 | -3 | 0.667 |
ULK1 |
0.799 | 0.034 | -3 | 0.771 |
IKKB |
0.799 | -0.041 | -2 | 0.672 |
GCN2 |
0.799 | -0.083 | 2 | 0.774 |
CLK3 |
0.798 | 0.039 | 1 | 0.804 |
RAF1 |
0.797 | -0.028 | 1 | 0.823 |
TBK1 |
0.797 | -0.035 | 1 | 0.759 |
CAMK2G |
0.796 | -0.003 | 2 | 0.773 |
WNK1 |
0.796 | 0.039 | -2 | 0.820 |
PDHK1 |
0.795 | -0.023 | 1 | 0.828 |
NDR2 |
0.795 | -0.024 | -3 | 0.655 |
BMPR2 |
0.795 | -0.077 | -2 | 0.831 |
MOS |
0.795 | -0.012 | 1 | 0.811 |
PDHK4 |
0.794 | -0.130 | 1 | 0.821 |
MTOR |
0.794 | -0.095 | 1 | 0.762 |
ATR |
0.794 | 0.023 | 1 | 0.786 |
PRKD1 |
0.793 | 0.022 | -3 | 0.656 |
MST4 |
0.793 | 0.008 | 2 | 0.831 |
PKN3 |
0.793 | -0.006 | -3 | 0.683 |
ERK5 |
0.792 | 0.029 | 1 | 0.782 |
NEK9 |
0.792 | 0.051 | 2 | 0.811 |
RIPK3 |
0.792 | -0.029 | 3 | 0.675 |
FAM20C |
0.792 | 0.064 | 2 | 0.553 |
HUNK |
0.792 | 0.056 | 2 | 0.762 |
CAMK1B |
0.792 | -0.041 | -3 | 0.723 |
IKKE |
0.791 | -0.065 | 1 | 0.746 |
PKCD |
0.791 | 0.023 | 2 | 0.778 |
NLK |
0.790 | -0.035 | 1 | 0.779 |
NUAK2 |
0.790 | 0.004 | -3 | 0.686 |
KIS |
0.790 | 0.024 | 1 | 0.651 |
IKKA |
0.790 | -0.003 | -2 | 0.662 |
SKMLCK |
0.789 | 0.008 | -2 | 0.806 |
PIM1 |
0.789 | 0.029 | -3 | 0.618 |
MLK1 |
0.789 | -0.057 | 2 | 0.792 |
CDKL1 |
0.789 | -0.029 | -3 | 0.670 |
SRPK1 |
0.788 | 0.017 | -3 | 0.611 |
MARK4 |
0.788 | 0.008 | 4 | 0.773 |
CAMK2D |
0.788 | -0.002 | -3 | 0.695 |
BCKDK |
0.788 | -0.079 | -1 | 0.594 |
TGFBR2 |
0.788 | -0.057 | -2 | 0.754 |
PLK1 |
0.788 | 0.060 | -2 | 0.806 |
CDKL5 |
0.787 | 0.006 | -3 | 0.657 |
NEK2 |
0.787 | 0.097 | 2 | 0.775 |
LATS2 |
0.787 | -0.019 | -5 | 0.735 |
GRK5 |
0.787 | -0.084 | -3 | 0.742 |
TSSK1 |
0.787 | 0.041 | -3 | 0.700 |
NIK |
0.786 | -0.060 | -3 | 0.742 |
CHAK2 |
0.786 | -0.022 | -1 | 0.643 |
AMPKA1 |
0.786 | -0.004 | -3 | 0.689 |
PRKD2 |
0.786 | -0.003 | -3 | 0.601 |
RSK2 |
0.785 | -0.008 | -3 | 0.614 |
GRK1 |
0.785 | 0.025 | -2 | 0.722 |
PKN2 |
0.785 | -0.026 | -3 | 0.695 |
CAMLCK |
0.785 | -0.037 | -2 | 0.789 |
TSSK2 |
0.784 | 0.032 | -5 | 0.808 |
IRE1 |
0.784 | 0.002 | 1 | 0.791 |
GRK6 |
0.784 | -0.013 | 1 | 0.796 |
WNK3 |
0.784 | -0.126 | 1 | 0.810 |
P90RSK |
0.783 | -0.028 | -3 | 0.625 |
RSK3 |
0.783 | -0.023 | -3 | 0.618 |
NUAK1 |
0.783 | 0.009 | -3 | 0.632 |
NDR1 |
0.783 | -0.064 | -3 | 0.663 |
ANKRD3 |
0.782 | -0.068 | 1 | 0.855 |
NIM1 |
0.782 | -0.016 | 3 | 0.704 |
GRK4 |
0.781 | -0.064 | -2 | 0.788 |
MNK2 |
0.781 | 0.001 | -2 | 0.754 |
DAPK2 |
0.781 | -0.061 | -3 | 0.729 |
PKACG |
0.780 | -0.019 | -2 | 0.725 |
BMPR1B |
0.780 | 0.046 | 1 | 0.732 |
TTBK2 |
0.780 | -0.078 | 2 | 0.674 |
MAPKAPK3 |
0.780 | -0.052 | -3 | 0.610 |
AURC |
0.779 | 0.005 | -2 | 0.627 |
AMPKA2 |
0.779 | -0.013 | -3 | 0.653 |
ICK |
0.779 | -0.040 | -3 | 0.691 |
PKR |
0.779 | -0.006 | 1 | 0.826 |
MLK2 |
0.779 | -0.065 | 2 | 0.777 |
SRPK2 |
0.778 | -0.007 | -3 | 0.540 |
RIPK1 |
0.778 | -0.128 | 1 | 0.810 |
ATM |
0.778 | -0.034 | 1 | 0.727 |
HIPK4 |
0.778 | -0.026 | 1 | 0.716 |
CAMK2B |
0.778 | -0.006 | 2 | 0.734 |
ALK4 |
0.778 | -0.015 | -2 | 0.767 |
P70S6KB |
0.778 | -0.044 | -3 | 0.647 |
PKCB |
0.778 | 0.013 | 2 | 0.723 |
GRK7 |
0.778 | 0.051 | 1 | 0.732 |
MASTL |
0.777 | -0.156 | -2 | 0.761 |
PAK1 |
0.777 | -0.026 | -2 | 0.717 |
PAK3 |
0.777 | -0.038 | -2 | 0.716 |
PKCA |
0.777 | -0.006 | 2 | 0.719 |
PLK3 |
0.777 | 0.019 | 2 | 0.727 |
SGK3 |
0.777 | 0.029 | -3 | 0.608 |
TGFBR1 |
0.777 | 0.003 | -2 | 0.746 |
IRE2 |
0.777 | -0.016 | 2 | 0.768 |
PLK4 |
0.776 | 0.004 | 2 | 0.629 |
MAPKAPK2 |
0.776 | -0.021 | -3 | 0.557 |
CDK8 |
0.776 | -0.033 | 1 | 0.621 |
PKCG |
0.775 | -0.023 | 2 | 0.719 |
PKCZ |
0.775 | 0.000 | 2 | 0.752 |
MLK3 |
0.775 | -0.050 | 2 | 0.724 |
MELK |
0.775 | -0.042 | -3 | 0.644 |
CAMK4 |
0.774 | -0.089 | -3 | 0.659 |
TLK2 |
0.774 | -0.006 | 1 | 0.769 |
DLK |
0.774 | -0.179 | 1 | 0.812 |
PKCH |
0.774 | -0.011 | 2 | 0.717 |
ALK2 |
0.773 | 0.019 | -2 | 0.752 |
BRAF |
0.773 | 0.048 | -4 | 0.809 |
PRKD3 |
0.773 | -0.033 | -3 | 0.599 |
SRPK3 |
0.773 | -0.019 | -3 | 0.599 |
YSK4 |
0.772 | -0.076 | 1 | 0.769 |
LATS1 |
0.772 | -0.037 | -3 | 0.662 |
QSK |
0.772 | -0.026 | 4 | 0.752 |
VRK2 |
0.771 | -0.060 | 1 | 0.850 |
AURB |
0.771 | -0.020 | -2 | 0.622 |
CAMK2A |
0.771 | -0.030 | 2 | 0.743 |
MLK4 |
0.771 | -0.063 | 2 | 0.712 |
PKG2 |
0.771 | -0.002 | -2 | 0.666 |
ACVR2A |
0.771 | -0.023 | -2 | 0.740 |
MSK2 |
0.771 | -0.066 | -3 | 0.594 |
NEK5 |
0.770 | 0.063 | 1 | 0.840 |
CDK19 |
0.770 | -0.028 | 1 | 0.583 |
RSK4 |
0.770 | -0.016 | -3 | 0.575 |
MNK1 |
0.770 | -0.026 | -2 | 0.766 |
MEK1 |
0.770 | -0.095 | 2 | 0.794 |
QIK |
0.769 | -0.092 | -3 | 0.696 |
PERK |
0.769 | -0.054 | -2 | 0.768 |
PAK6 |
0.769 | -0.027 | -2 | 0.621 |
WNK4 |
0.769 | -0.009 | -2 | 0.806 |
PHKG1 |
0.769 | -0.073 | -3 | 0.656 |
JNK3 |
0.769 | 0.006 | 1 | 0.595 |
PKACB |
0.768 | -0.006 | -2 | 0.662 |
SMG1 |
0.768 | -0.062 | 1 | 0.733 |
HRI |
0.768 | -0.081 | -2 | 0.797 |
ACVR2B |
0.768 | -0.035 | -2 | 0.751 |
DYRK2 |
0.768 | -0.015 | 1 | 0.616 |
PAK2 |
0.768 | -0.063 | -2 | 0.697 |
PINK1 |
0.767 | -0.015 | 1 | 0.802 |
MSK1 |
0.767 | -0.038 | -3 | 0.598 |
JNK2 |
0.767 | 0.017 | 1 | 0.557 |
CDK5 |
0.767 | -0.002 | 1 | 0.636 |
IRAK4 |
0.767 | -0.028 | 1 | 0.819 |
CDK13 |
0.767 | -0.025 | 1 | 0.589 |
CLK1 |
0.767 | -0.023 | -3 | 0.600 |
MARK2 |
0.766 | -0.026 | 4 | 0.677 |
SIK |
0.766 | -0.059 | -3 | 0.606 |
DNAPK |
0.766 | -0.009 | 1 | 0.665 |
AKT2 |
0.765 | -0.015 | -3 | 0.548 |
MARK3 |
0.765 | -0.023 | 4 | 0.715 |
P38A |
0.765 | -0.010 | 1 | 0.661 |
CHAK1 |
0.765 | -0.090 | 2 | 0.703 |
PIM2 |
0.765 | -0.008 | -3 | 0.601 |
MYLK4 |
0.765 | -0.061 | -2 | 0.723 |
PRP4 |
0.765 | 0.011 | -3 | 0.694 |
CLK4 |
0.765 | -0.039 | -3 | 0.620 |
MEKK2 |
0.765 | -0.035 | 2 | 0.778 |
PKCT |
0.764 | -0.017 | 2 | 0.726 |
CHK1 |
0.764 | -0.075 | -3 | 0.644 |
ZAK |
0.764 | -0.066 | 1 | 0.795 |
MEKK3 |
0.763 | -0.100 | 1 | 0.792 |
P38B |
0.763 | 0.005 | 1 | 0.584 |
PRKX |
0.762 | -0.001 | -3 | 0.506 |
SSTK |
0.762 | 0.019 | 4 | 0.738 |
ERK1 |
0.762 | -0.017 | 1 | 0.578 |
CDK7 |
0.762 | -0.068 | 1 | 0.615 |
CDK1 |
0.762 | -0.021 | 1 | 0.552 |
BMPR1A |
0.762 | 0.005 | 1 | 0.722 |
MEKK1 |
0.762 | -0.107 | 1 | 0.828 |
DCAMKL1 |
0.762 | -0.045 | -3 | 0.613 |
BRSK2 |
0.761 | -0.088 | -3 | 0.656 |
MAPKAPK5 |
0.761 | -0.102 | -3 | 0.596 |
CK1G1 |
0.761 | -0.026 | -3 | 0.469 |
CK1E |
0.761 | -0.029 | -3 | 0.470 |
CDK18 |
0.761 | -0.025 | 1 | 0.546 |
BRSK1 |
0.761 | -0.077 | -3 | 0.633 |
SNRK |
0.761 | -0.128 | 2 | 0.676 |
AURA |
0.761 | -0.047 | -2 | 0.586 |
CDK2 |
0.760 | -0.028 | 1 | 0.635 |
MPSK1 |
0.760 | 0.041 | 1 | 0.812 |
TLK1 |
0.760 | -0.083 | -2 | 0.800 |
GAK |
0.760 | 0.090 | 1 | 0.858 |
TTBK1 |
0.759 | -0.086 | 2 | 0.599 |
MST3 |
0.759 | -0.021 | 2 | 0.790 |
IRAK1 |
0.759 | -0.101 | -1 | 0.574 |
NEK4 |
0.759 | 0.065 | 1 | 0.800 |
CLK2 |
0.758 | 0.003 | -3 | 0.593 |
MARK1 |
0.758 | -0.058 | 4 | 0.736 |
AKT1 |
0.758 | -0.020 | -3 | 0.555 |
CDK12 |
0.758 | -0.033 | 1 | 0.561 |
CDK9 |
0.758 | -0.037 | 1 | 0.601 |
HIPK1 |
0.758 | -0.015 | 1 | 0.645 |
P38G |
0.758 | -0.012 | 1 | 0.476 |
MEK5 |
0.758 | -0.170 | 2 | 0.790 |
PKACA |
0.758 | -0.009 | -2 | 0.612 |
ERK2 |
0.757 | -0.052 | 1 | 0.611 |
CAMK1G |
0.757 | -0.079 | -3 | 0.625 |
NEK8 |
0.757 | -0.043 | 2 | 0.792 |
DYRK1A |
0.757 | -0.025 | 1 | 0.682 |
PKCI |
0.757 | -0.023 | 2 | 0.733 |
PHKG2 |
0.756 | -0.074 | -3 | 0.646 |
DCAMKL2 |
0.756 | -0.062 | -3 | 0.646 |
HIPK3 |
0.756 | -0.021 | 1 | 0.660 |
CDK3 |
0.756 | 0.012 | 1 | 0.502 |
GRK2 |
0.756 | -0.086 | -2 | 0.665 |
DRAK1 |
0.756 | -0.124 | 1 | 0.708 |
HIPK2 |
0.755 | -0.010 | 1 | 0.526 |
SMMLCK |
0.755 | -0.070 | -3 | 0.682 |
CAMKK1 |
0.755 | -0.044 | -2 | 0.667 |
LKB1 |
0.754 | 0.022 | -3 | 0.744 |
TAO3 |
0.754 | -0.083 | 1 | 0.784 |
CDK17 |
0.754 | -0.039 | 1 | 0.484 |
P70S6K |
0.753 | -0.058 | -3 | 0.574 |
NEK1 |
0.753 | 0.078 | 1 | 0.816 |
NEK11 |
0.753 | -0.082 | 1 | 0.795 |
PKCE |
0.753 | -0.009 | 2 | 0.706 |
EEF2K |
0.752 | 0.020 | 3 | 0.768 |
CK1D |
0.752 | -0.036 | -3 | 0.429 |
PDK1 |
0.751 | -0.047 | 1 | 0.817 |
P38D |
0.751 | 0.003 | 1 | 0.510 |
TNIK |
0.751 | 0.016 | 3 | 0.777 |
PLK2 |
0.751 | -0.005 | -3 | 0.706 |
CK2A2 |
0.750 | 0.048 | 1 | 0.594 |
HGK |
0.750 | -0.011 | 3 | 0.772 |
PKN1 |
0.750 | -0.026 | -3 | 0.586 |
ERK7 |
0.749 | -0.005 | 2 | 0.525 |
CAMKK2 |
0.749 | -0.043 | -2 | 0.650 |
MEKK6 |
0.749 | -0.023 | 1 | 0.798 |
TAO2 |
0.749 | -0.095 | 2 | 0.815 |
MINK |
0.748 | -0.028 | 1 | 0.797 |
PASK |
0.748 | -0.096 | -3 | 0.691 |
CAMK1D |
0.748 | -0.064 | -3 | 0.527 |
CK1A2 |
0.747 | -0.046 | -3 | 0.428 |
SGK1 |
0.747 | -0.004 | -3 | 0.470 |
CDK14 |
0.747 | -0.043 | 1 | 0.593 |
DYRK3 |
0.747 | -0.037 | 1 | 0.645 |
AKT3 |
0.747 | -0.011 | -3 | 0.483 |
TAK1 |
0.747 | -0.064 | 1 | 0.819 |
DYRK4 |
0.747 | -0.025 | 1 | 0.544 |
MST2 |
0.746 | -0.091 | 1 | 0.799 |
GSK3A |
0.746 | -0.033 | 4 | 0.361 |
GSK3B |
0.746 | -0.055 | 4 | 0.348 |
CDK16 |
0.746 | -0.018 | 1 | 0.505 |
GRK3 |
0.746 | -0.069 | -2 | 0.625 |
DYRK1B |
0.745 | -0.040 | 1 | 0.585 |
NEK3 |
0.745 | 0.001 | 1 | 0.792 |
PAK5 |
0.745 | -0.076 | -2 | 0.559 |
MAP3K15 |
0.745 | -0.072 | 1 | 0.782 |
PBK |
0.744 | 0.077 | 1 | 0.815 |
GCK |
0.744 | -0.082 | 1 | 0.774 |
MRCKB |
0.743 | -0.028 | -3 | 0.589 |
LOK |
0.743 | -0.063 | -2 | 0.717 |
RIPK2 |
0.743 | -0.108 | 1 | 0.771 |
CDK10 |
0.743 | -0.032 | 1 | 0.578 |
ROCK2 |
0.742 | -0.014 | -3 | 0.621 |
DAPK3 |
0.742 | -0.067 | -3 | 0.639 |
JNK1 |
0.741 | -0.025 | 1 | 0.531 |
VRK1 |
0.741 | -0.099 | 2 | 0.816 |
YSK1 |
0.741 | -0.036 | 2 | 0.784 |
PDHK3_TYR |
0.740 | 0.044 | 4 | 0.831 |
MRCKA |
0.740 | -0.040 | -3 | 0.595 |
STK33 |
0.740 | -0.080 | 2 | 0.589 |
CDK6 |
0.740 | -0.027 | 1 | 0.583 |
LRRK2 |
0.740 | -0.123 | 2 | 0.809 |
PAK4 |
0.740 | -0.074 | -2 | 0.567 |
KHS1 |
0.739 | -0.031 | 1 | 0.772 |
MEK2 |
0.739 | -0.098 | 2 | 0.779 |
MAK |
0.739 | 0.001 | -2 | 0.635 |
CK2A1 |
0.738 | 0.024 | 1 | 0.562 |
HPK1 |
0.738 | -0.080 | 1 | 0.757 |
CAMK1A |
0.738 | -0.061 | -3 | 0.512 |
BUB1 |
0.737 | -0.011 | -5 | 0.715 |
PKG1 |
0.737 | -0.027 | -2 | 0.596 |
MST1 |
0.737 | -0.108 | 1 | 0.786 |
KHS2 |
0.737 | -0.027 | 1 | 0.770 |
CHK2 |
0.737 | -0.073 | -3 | 0.497 |
PKMYT1_TYR |
0.736 | -0.007 | 3 | 0.778 |
TTK |
0.735 | -0.019 | -2 | 0.806 |
SLK |
0.734 | -0.109 | -2 | 0.654 |
DAPK1 |
0.734 | -0.079 | -3 | 0.631 |
BIKE |
0.734 | 0.080 | 1 | 0.777 |
CDK4 |
0.733 | -0.043 | 1 | 0.543 |
DMPK1 |
0.733 | -0.013 | -3 | 0.605 |
TESK1_TYR |
0.732 | -0.083 | 3 | 0.804 |
MAP2K7_TYR |
0.732 | -0.122 | 2 | 0.809 |
MAP2K4_TYR |
0.732 | -0.081 | -1 | 0.634 |
OSR1 |
0.731 | -0.057 | 2 | 0.772 |
MAP2K6_TYR |
0.731 | -0.065 | -1 | 0.632 |
HASPIN |
0.731 | -0.032 | -1 | 0.526 |
ROCK1 |
0.730 | -0.030 | -3 | 0.598 |
SBK |
0.729 | -0.044 | -3 | 0.437 |
MOK |
0.729 | -0.030 | 1 | 0.661 |
PDHK4_TYR |
0.729 | -0.073 | 2 | 0.822 |
EPHA6 |
0.728 | -0.019 | -1 | 0.610 |
PINK1_TYR |
0.728 | -0.142 | 1 | 0.811 |
LIMK2_TYR |
0.728 | -0.031 | -3 | 0.755 |
MYO3B |
0.728 | -0.018 | 2 | 0.788 |
TYK2 |
0.728 | -0.036 | 1 | 0.812 |
BMPR2_TYR |
0.727 | -0.105 | -1 | 0.603 |
RET |
0.727 | -0.083 | 1 | 0.801 |
TYRO3 |
0.727 | -0.061 | 3 | 0.718 |
TNNI3K_TYR |
0.726 | 0.101 | 1 | 0.845 |
JAK2 |
0.725 | -0.029 | 1 | 0.812 |
PDHK1_TYR |
0.725 | -0.140 | -1 | 0.623 |
ROS1 |
0.725 | -0.037 | 3 | 0.683 |
CRIK |
0.725 | -0.030 | -3 | 0.549 |
YES1 |
0.724 | -0.027 | -1 | 0.609 |
ASK1 |
0.724 | -0.087 | 1 | 0.771 |
CSF1R |
0.724 | -0.061 | 3 | 0.722 |
FGR |
0.723 | -0.028 | 1 | 0.853 |
EPHB4 |
0.723 | -0.074 | -1 | 0.589 |
MST1R |
0.723 | -0.119 | 3 | 0.731 |
HCK |
0.722 | -0.031 | -1 | 0.580 |
FER |
0.722 | -0.048 | 1 | 0.845 |
LIMK1_TYR |
0.722 | -0.138 | 2 | 0.813 |
ABL2 |
0.722 | -0.046 | -1 | 0.592 |
DDR1 |
0.721 | -0.073 | 4 | 0.739 |
ALPHAK3 |
0.721 | -0.078 | -1 | 0.559 |
MYO3A |
0.720 | -0.070 | 1 | 0.770 |
LCK |
0.720 | -0.013 | -1 | 0.580 |
TNK2 |
0.719 | -0.042 | 3 | 0.692 |
ABL1 |
0.719 | -0.043 | -1 | 0.596 |
SRMS |
0.719 | -0.055 | 1 | 0.820 |
BLK |
0.719 | 0.004 | -1 | 0.583 |
AAK1 |
0.719 | 0.099 | 1 | 0.691 |
TAO1 |
0.718 | -0.109 | 1 | 0.740 |
TNK1 |
0.718 | -0.037 | 3 | 0.700 |
AXL |
0.717 | -0.063 | 3 | 0.701 |
JAK1 |
0.716 | 0.001 | 1 | 0.763 |
PDGFRB |
0.716 | -0.107 | 3 | 0.727 |
EPHA4 |
0.716 | -0.053 | 2 | 0.715 |
FLT3 |
0.716 | -0.097 | 3 | 0.718 |
EPHB1 |
0.716 | -0.076 | 1 | 0.832 |
MERTK |
0.715 | -0.048 | 3 | 0.704 |
EPHB3 |
0.715 | -0.068 | -1 | 0.581 |
TXK |
0.715 | -0.060 | 1 | 0.779 |
JAK3 |
0.715 | -0.127 | 1 | 0.783 |
KIT |
0.714 | -0.110 | 3 | 0.731 |
EPHB2 |
0.714 | -0.071 | -1 | 0.567 |
ITK |
0.714 | -0.092 | -1 | 0.569 |
CK1A |
0.713 | -0.060 | -3 | 0.352 |
KDR |
0.713 | -0.098 | 3 | 0.686 |
INSRR |
0.713 | -0.102 | 3 | 0.666 |
FYN |
0.713 | -0.014 | -1 | 0.549 |
PTK6 |
0.713 | -0.088 | -1 | 0.548 |
STLK3 |
0.713 | -0.117 | 1 | 0.759 |
NEK10_TYR |
0.712 | -0.070 | 1 | 0.678 |
YANK3 |
0.712 | -0.082 | 2 | 0.383 |
FGFR1 |
0.711 | -0.113 | 3 | 0.696 |
LTK |
0.711 | -0.067 | 3 | 0.675 |
TEC |
0.711 | -0.085 | -1 | 0.541 |
FGFR2 |
0.711 | -0.145 | 3 | 0.718 |
ALK |
0.709 | -0.077 | 3 | 0.645 |
WEE1_TYR |
0.709 | -0.089 | -1 | 0.541 |
BTK |
0.708 | -0.151 | -1 | 0.549 |
LYN |
0.708 | -0.057 | 3 | 0.664 |
TEK |
0.708 | -0.141 | 3 | 0.666 |
BMX |
0.708 | -0.093 | -1 | 0.499 |
PDGFRA |
0.707 | -0.154 | 3 | 0.729 |
EPHA1 |
0.707 | -0.091 | 3 | 0.688 |
MET |
0.706 | -0.125 | 3 | 0.706 |
EPHA7 |
0.706 | -0.085 | 2 | 0.726 |
FRK |
0.705 | -0.094 | -1 | 0.587 |
PTK2B |
0.705 | -0.047 | -1 | 0.594 |
NTRK1 |
0.705 | -0.147 | -1 | 0.574 |
SRC |
0.704 | -0.045 | -1 | 0.566 |
NTRK2 |
0.704 | -0.138 | 3 | 0.681 |
INSR |
0.703 | -0.097 | 3 | 0.644 |
CK1G3 |
0.703 | -0.054 | -3 | 0.315 |
EPHA3 |
0.702 | -0.127 | 2 | 0.700 |
FLT1 |
0.702 | -0.152 | -1 | 0.562 |
DDR2 |
0.702 | -0.027 | 3 | 0.663 |
NTRK3 |
0.701 | -0.111 | -1 | 0.540 |
ERBB2 |
0.701 | -0.149 | 1 | 0.748 |
FLT4 |
0.700 | -0.153 | 3 | 0.691 |
MATK |
0.700 | -0.115 | -1 | 0.536 |
FGFR3 |
0.699 | -0.149 | 3 | 0.693 |
CSK |
0.698 | -0.106 | 2 | 0.733 |
EPHA5 |
0.698 | -0.099 | 2 | 0.703 |
EGFR |
0.698 | -0.084 | 1 | 0.672 |
EPHA8 |
0.694 | -0.119 | -1 | 0.552 |
FGFR4 |
0.693 | -0.110 | -1 | 0.540 |
SYK |
0.692 | -0.064 | -1 | 0.503 |
PTK2 |
0.691 | -0.081 | -1 | 0.525 |
IGF1R |
0.688 | -0.105 | 3 | 0.591 |
MUSK |
0.687 | -0.124 | 1 | 0.664 |
EPHA2 |
0.687 | -0.117 | -1 | 0.510 |
ERBB4 |
0.679 | -0.099 | 1 | 0.667 |
YANK2 |
0.678 | -0.100 | 2 | 0.400 |
FES |
0.676 | -0.128 | -1 | 0.501 |
ZAP70 |
0.672 | -0.074 | -1 | 0.468 |
CK1G2 |
0.670 | -0.086 | -3 | 0.397 |