Motif 932 (n=139)

Position-wise Probabilities
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uniprot genes site source protein function
H3BN57 BLOC1S5-TXNDC5 S21 ochoa Biogenesis of lysosome-related organelles complex 1 subunit 5 (Protein Muted homolog) None
O14686 KMT2D S3238 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14965 AURKA S342 psp Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.
O15063 GARRE1 S355 ochoa Granule associated Rac and RHOG effector protein 1 (GARRE1) Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}.
O15381 NVL S180 ochoa Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}.
O43182 ARHGAP6 S837 ochoa Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.
O43314 PPIP5K2 S1091 ochoa Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}.
O43491 EPB41L2 S614 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O75044 SRGAP2 S822 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75146 HIP1R S1045 ochoa Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.
O94823 ATP10B S984 ochoa Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}.
O95622 ADCY5 S96 ochoa Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:24700542, PubMed:26206488). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}.
P00533 EGFR S1162 ochoa Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.
P00734 F2 S199 ochoa Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208). {ECO:0000269|PubMed:2019570, ECO:0000269|PubMed:21976677, ECO:0000269|PubMed:2856554, ECO:0000269|PubMed:30568593, ECO:0000269|PubMed:9780208}.
P06733 ENO1 S40 ochoa Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
P08034 GJB1 Y243 psp Gap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDa liver protein) One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
P08670 VIM S72 ochoa|psp Vimentin Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}.
P09104 ENO2 S40 ochoa Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.
P10636 MAPT S369 psp Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P13929 ENO3 S40 ochoa Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}.
P15924 DSP S2231 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P19823 ITIH2 S55 ochoa Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
P31629 HIVEP2 S619 ochoa Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
P32298 GRK4 S485 psp G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.
P34947 GRK5 S484 ochoa|psp G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405, ECO:0000269|PubMed:21728385}.
P35251 RFC1 S1104 ochoa Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}.
P41231 P2RY2 S243 psp P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
P41240 CSK S364 psp Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
P42330 AKR1C3 S32 ochoa Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
P43250 GRK6 S484 ochoa|psp G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
P49792 RANBP2 S1981 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49959 MRE11 S641 ochoa Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}.
P51116 FXR2 S654 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P51825 AFF1 S620 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P52888 THOP1 S172 ochoa Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}.
P52895 AKR1C2 S32 ochoa Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699, ECO:0000269|PubMed:8573067}.
P54296 MYOM2 S627 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54296 MYOM2 S1191 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54886 ALDH18A1 S427 ochoa Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761, ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891, ECO:0000269|PubMed:39506109}.
P57078 RIPK4 S370 ochoa Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}.
P62826 RAN S135 ochoa|psp GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:11336674, PubMed:26272610, PubMed:29040603, PubMed:7819259, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:12194828, PubMed:29040603, PubMed:8421051). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640). {ECO:0000269|PubMed:10400640, ECO:0000269|PubMed:10408446, ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:7819259, ECO:0000269|PubMed:8276887, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8636225, ECO:0000269|PubMed:8692944, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9428644, ECO:0000269|PubMed:9822603, ECO:0000305|PubMed:26272610}.
P62937 PPIA S110 ochoa Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}.
P68104 EEF1A1 S175 ochoa Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}.
P78524 DENND2B S637 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
Q00653 NFKB2 S22 ochoa Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}.
Q01804 OTUD4 S349 ochoa OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}.
Q02952 AKAP12 S1497 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q04828 AKR1C1 S32 ochoa Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}.
Q08050 FOXM1 S567 psp Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.
Q09666 AHNAK S845 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q13061 TRDN S605 ochoa Triadin Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}.
Q13188 STK3 S406 ochoa Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}.
Q14157 UBAP2L S493 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14324 MYBPC2 S60 ochoa Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Q14790 CASP8 S347 psp Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.
Q14956 GPNMB S542 psp Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type) Could be a melanogenic enzyme. {ECO:0000250}.
Q15849 SLC14A2 S477 psp Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney) [Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:11502588, ECO:0000269|PubMed:17702749}.; FUNCTION: [Isoform 2]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:8647271, ECO:0000269|PubMed:8997401}.
Q16891 IMMT S356 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q2TB10 ZNF800 S478 ochoa Zinc finger protein 800 May be involved in transcriptional regulation.
Q3MJ13 WDR72 S962 ochoa WD repeat-containing protein 72 Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4, ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}.
Q3V6T2 CCDC88A S1788 ochoa Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}.
Q5JSH3 WDR44 S66 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q5JSH3 WDR44 S614 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q5JTV8 TOR1AIP1 S154 ochoa Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.
Q5TC84 OGFRL1 S330 ochoa Opioid growth factor receptor-like protein 1 None
Q5VTE0 EEF1A1P5 S175 ochoa Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}.
Q5VUA4 ZNF318 S1869 ochoa Zinc finger protein 318 (Endocrine regulatory protein) [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.
Q68D51 DENND2C S271 ochoa DENN domain-containing protein 2C Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.
Q68EM7 ARHGAP17 S497 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6P2P2 PRMT9 S547 ochoa Protein arginine N-methyltransferase 9 (Protein arginine N-methyltransferase 10) (EC 2.1.1.320) Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344). {ECO:0000269|PubMed:25737013, ECO:0000269|PubMed:25979344}.
Q6PL18 ATAD2 S740 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q6ZU35 CRACD S819 ochoa Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}.
Q7L1Q6 BZW1 S391 ochoa eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015). {ECO:0000269|PubMed:11524015, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}.
Q7Z2Z1 TICRR S1115 psp Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z5J4 RAI1 S683 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q7Z6E9 RBBP6 S1353 ochoa E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}.
Q86UD3 MARCHF3 S53 ochoa E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3) E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000250|UniProtKB:Q5XIE5}.
Q86UE4 MTDH S529 ochoa Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.
Q8IUC4 RHPN2 S616 ochoa Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}.
Q8IVF2 AHNAK2 S3782 ochoa Protein AHNAK2 None
Q8IVL1 NAV2 S1120 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IVW6 ARID3B S89 ochoa AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}.
Q8IWB9 TEX2 S222 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8IZT6 ASPM S565 ochoa Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}.
Q8N137 CNTROB S78 ochoa Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}.
Q8N4N8 KIF2B S617 psp Kinesin-like protein KIF2B Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}.
Q8NI35 PATJ S351 ochoa InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}.
Q8TDH9 BLOC1S5 S25 ochoa Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:32565547). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:32565547}.
Q8TDP1 RNASEH2C S92 ochoa Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.
Q8TEQ0 SNX29 S328 ochoa Sorting nexin-29 (RUN domain-containing protein 2A) None
Q92547 TOPBP1 S817 ochoa DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}.
Q92608 DOCK2 S1706 ochoa Dedicator of cytokinesis protein 2 Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.
Q96B01 RAD51AP1 S280 ochoa RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). {ECO:0000269|PubMed:17996710, ECO:0000269|PubMed:17996711, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22375013, ECO:0000269|PubMed:25288561, ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31400850, ECO:0000269|PubMed:32350107, ECO:0000269|PubMed:9396801}.
Q96BU1 S100PBP S101 ochoa S100P-binding protein (S100P-binding protein Riken) None
Q96BY7 ATG2B S1160 ochoa Autophagy-related protein 2 homolog B Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}.
Q96GQ7 DDX27 S79 ochoa Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154). {ECO:0000269|PubMed:25825154}.
Q96JJ3 ELMO2 S501 ochoa Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:11703939, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:27476657}.
Q96Q11 TRNT1 S399 ochoa CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase) Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates (PubMed:11504732, PubMed:25193871, PubMed:25640237, PubMed:25652405, PubMed:29454993, PubMed:30959222, PubMed:31011209, PubMed:34023389). tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (PubMed:22076379, PubMed:25640237). Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ANKZF1 and repair by ELAC1 (PubMed:31011209). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts (PubMed:22076379, PubMed:25640237). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded (PubMed:22076379, PubMed:25640237). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (PubMed:25640237). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (PubMed:25640237). {ECO:0000269|PubMed:11504732, ECO:0000269|PubMed:22076379, ECO:0000269|PubMed:25193871, ECO:0000269|PubMed:25640237, ECO:0000269|PubMed:25652405, ECO:0000269|PubMed:29454993, ECO:0000269|PubMed:30959222, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:34023389}.; FUNCTION: [Isoform 2]: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro). {ECO:0000269|PubMed:17204286}.
Q96QC0 PPP1R10 S398 ochoa Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}.
Q99584 S100A13 S62 ochoa Protein S100-A13 (S100 calcium-binding protein A13) Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250|UniProtKB:P97352, ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}.
Q9BT25 HAUS8 S357 ochoa HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.
Q9BW04 SARG S487 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BW91 NUDT9 S182 ochoa ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}.
Q9BX66 SORBS1 S665 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9BYB0 SHANK3 S483 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9H2Y7 ZNF106 S508 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H5Q4 TFB2M S197 psp Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2) S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:12068295, PubMed:15526033, PubMed:20410300, PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033, PubMed:29149603). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:29149603, ECO:0000305|PubMed:12897151, ECO:0000305|PubMed:17031457}.
Q9H6A9 PCNX3 S128 ochoa Pecanex-like protein 3 (Pecanex homolog protein 3) None
Q9H9A5 CNOT10 S21 ochoa CCR4-NOT transcription complex subunit 10 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. {ECO:0000269|PubMed:23221646}.
Q9HC35 EML4 S176 ochoa Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.
Q9HCH5 SYTL2 S509 ochoa Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.
Q9NQS7 INCENP S330 ochoa Inner centromere protein Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
Q9NR99 MXRA5 S1304 ochoa Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. {ECO:0000269|PubMed:27599751}.
Q9NUL3 STAU2 S432 ochoa Double-stranded RNA-binding protein Staufen homolog 2 RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}.
Q9UBT2 UBA2 S507 ochoa SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.
Q9UHW9 SLC12A6 S93 ochoa Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.
Q9ULE3 DENND2A S504 ochoa DENN domain-containing protein 2A Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}.
Q9UMZ2 SYNRG S1009 ochoa Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}.
Q9Y426 C2CD2 S522 ochoa C2 domain-containing protein 2 (Transmembrane protein 24-like) None
Q9Y450 HBS1L S117 ochoa HBS1-like protein (EC 3.6.5.-) (ERFS) GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}.
Q9Y4G8 RAPGEF2 S1089 ochoa Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.
Q9Y6A5 TACC3 S524 ochoa Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
P34932 HSPA4 S363 Sugiyama Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) None
O15119 TBX3 S723 Sugiyama T-box transcription factor TBX3 (T-box protein 3) Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}.
Q15398 DLGAP5 S446 Sugiyama Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.
Q99497 PARK7 S142 Sugiyama Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}.
O43314 PPIP5K2 Y256 Sugiyama Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}.
Q6PFW1 PPIP5K1 Y267 Sugiyama Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}.
Q15056 EIF4H S66 Sugiyama Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}.
P23284 PPIB S150 Sugiyama Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.
P35637 FUS S360 Sugiyama RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.
Q9H0C5 BTBD1 S273 Sugiyama BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8) Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250|UniProtKB:P58544, ECO:0000269|PubMed:14528312}.
P10768 ESD S189 Sugiyama S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269|PubMed:3770744, ECO:0000269|PubMed:4768551}.
Q15349 RPS6KA2 S634 Sugiyama Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Q9NY33 DPP3 S225 Sugiyama Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.
P35250 RFC2 S85 Sugiyama Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds ATP (By similarity). {ECO:0000250, ECO:0000269|PubMed:9488738}.
Q9UHG3 PCYOX1 S447 Sugiyama Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase) Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463). {ECO:0000250|UniProtKB:F1N2K1, ECO:0000269|PubMed:10585463, ECO:0000269|PubMed:11078725, ECO:0000269|PubMed:12186880}.
P30622 CLIP1 S383 Sugiyama CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
O75376 NCOR1 S2164 Sugiyama Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
Download
reactome_id name p -log10_p
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.000036 4.446
R-HSA-75153 Apoptotic execution phase 0.000184 3.736
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.000223 3.652
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.000378 3.422
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.000682 3.166
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.000682 3.166
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.000810 3.091
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.000961 3.017
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.001122 2.950
R-HSA-9613829 Chaperone Mediated Autophagy 0.001453 2.838
R-HSA-9675135 Diseases of DNA repair 0.001866 2.729
R-HSA-8857538 PTK6 promotes HIF1A stabilization 0.003434 2.464
R-HSA-9012852 Signaling by NOTCH3 0.003238 2.490
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.004006 2.397
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.004715 2.327
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.006266 2.203
R-HSA-69091 Polymerase switching 0.010393 1.983
R-HSA-69109 Leading Strand Synthesis 0.010393 1.983
R-HSA-5693538 Homology Directed Repair 0.008917 2.050
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.007390 2.131
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.006346 2.198
R-HSA-428543 Inactivation of CDC42 and RAC1 0.005993 2.222
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.007764 2.110
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.007443 2.128
R-HSA-69278 Cell Cycle, Mitotic 0.010638 1.973
R-HSA-1640170 Cell Cycle 0.010011 2.000
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.007764 2.110
R-HSA-141424 Amplification of signal from the kinetochores 0.012823 1.892
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.012823 1.892
R-HSA-110312 Translesion synthesis by REV1 0.014387 1.842
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.013281 1.877
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.013761 1.861
R-HSA-5656121 Translesion synthesis by POLI 0.015844 1.800
R-HSA-5655862 Translesion synthesis by POLK 0.017360 1.760
R-HSA-68877 Mitotic Prometaphase 0.016361 1.786
R-HSA-9675151 Disorders of Developmental Biology 0.017360 1.760
R-HSA-69620 Cell Cycle Checkpoints 0.017552 1.756
R-HSA-70263 Gluconeogenesis 0.016724 1.777
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.020570 1.687
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.022261 1.652
R-HSA-180292 GAB1 signalosome 0.020570 1.687
R-HSA-110320 Translesion Synthesis by POLH 0.022261 1.652
R-HSA-69618 Mitotic Spindle Checkpoint 0.022066 1.656
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.022261 1.652
R-HSA-70171 Glycolysis 0.022066 1.656
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.024007 1.620
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.024007 1.620
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.024007 1.620
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.024007 1.620
R-HSA-5693532 DNA Double-Strand Break Repair 0.024348 1.614
R-HSA-5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... 0.028104 1.551
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.027660 1.558
R-HSA-190704 Oligomerization of connexins into connexons 0.028104 1.551
R-HSA-163282 Mitochondrial transcription initiation 0.028104 1.551
R-HSA-190827 Transport of connexins along the secretory pathway 0.028104 1.551
R-HSA-9636667 Manipulation of host energy metabolism 0.028104 1.551
R-HSA-6784531 tRNA processing in the nucleus 0.029702 1.527
R-HSA-69186 Lagging Strand Synthesis 0.025807 1.588
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.029565 1.529
R-HSA-8848021 Signaling by PTK6 0.030784 1.512
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.030784 1.512
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.028262 1.549
R-HSA-109581 Apoptosis 0.029443 1.531
R-HSA-8854521 Interaction between PHLDA1 and AURKA 0.037297 1.428
R-HSA-9672391 Defective F8 cleavage by thrombin 0.037297 1.428
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.046403 1.333
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.046403 1.333
R-HSA-1251932 PLCG1 events in ERBB2 signaling 0.055424 1.256
R-HSA-164525 Plus-strand DNA synthesis 0.073211 1.135
R-HSA-5603029 IkBA variant leads to EDA-ID 0.073211 1.135
R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 0.073211 1.135
R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR 0.073211 1.135
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.073211 1.135
R-HSA-9842640 Signaling by LTK in cancer 0.081980 1.086
R-HSA-162585 Uncoating of the HIV Virion 0.081980 1.086
R-HSA-162589 Reverse Transcription of HIV RNA 0.099271 1.003
R-HSA-164516 Minus-strand DNA synthesis 0.099271 1.003
R-HSA-3371378 Regulation by c-FLIP 0.099271 1.003
R-HSA-444257 RSK activation 0.099271 1.003
R-HSA-69416 Dimerization of procaspase-8 0.099271 1.003
R-HSA-212718 EGFR interacts with phospholipase C-gamma 0.099271 1.003
R-HSA-5218900 CASP8 activity is inhibited 0.107794 0.967
R-HSA-9700645 ALK mutants bind TKIs 0.107794 0.967
R-HSA-173107 Binding and entry of HIV virion 0.116238 0.935
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.035582 1.449
R-HSA-9615710 Late endosomal microautophagy 0.044264 1.354
R-HSA-390522 Striated Muscle Contraction 0.056084 1.251
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.124312 0.905
R-HSA-5656169 Termination of translesion DNA synthesis 0.044264 1.354
R-HSA-5693607 Processing of DNA double-strand break ends 0.053712 1.270
R-HSA-177929 Signaling by EGFR 0.124312 0.905
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.076950 1.114
R-HSA-73893 DNA Damage Bypass 0.102807 0.988
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.033527 1.475
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.124602 0.904
R-HSA-5660668 CLEC7A/inflammasome pathway 0.073211 1.135
R-HSA-9646399 Aggrephagy 0.074223 1.129
R-HSA-180746 Nuclear import of Rev protein 0.058568 1.232
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.068867 1.162
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.071529 1.146
R-HSA-177243 Interactions of Rev with host cellular proteins 0.074223 1.129
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 0.055424 1.256
R-HSA-2562578 TRIF-mediated programmed cell death 0.090666 1.043
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.132887 0.877
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 0.132887 0.877
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.035582 1.449
R-HSA-179812 GRB2 events in EGFR signaling 0.141095 0.850
R-HSA-5696400 Dual Incision in GG-NER 0.058568 1.232
R-HSA-5693537 Resolution of D-Loop Structures 0.056084 1.251
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.053640 1.271
R-HSA-9657688 Defective factor XII causes hereditary angioedema 0.037297 1.428
R-HSA-2179392 EGFR Transactivation by Gastrin 0.116238 0.935
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.091039 1.041
R-HSA-69275 G2/M Transition 0.132388 0.878
R-HSA-453274 Mitotic G2-G2/M phases 0.135740 0.867
R-HSA-75944 Transcription from mitochondrial promoters 0.037297 1.428
R-HSA-2025928 Calcineurin activates NFAT 0.107794 0.967
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.132887 0.877
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.037683 1.424
R-HSA-6794361 Neurexins and neuroligins 0.111891 0.951
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.040682 1.391
R-HSA-9693928 Defective RIPK1-mediated regulated necrosis 0.116238 0.935
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.091039 1.041
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.096871 1.014
R-HSA-6782135 Dual incision in TC-NER 0.130642 0.884
R-HSA-162909 Host Interactions of HIV factors 0.043484 1.362
R-HSA-416476 G alpha (q) signalling events 0.135119 0.869
R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria 0.037297 1.428
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.055424 1.256
R-HSA-199920 CREB phosphorylation 0.081980 1.086
R-HSA-426117 Cation-coupled Chloride cotransporters 0.090666 1.043
R-HSA-190861 Gap junction assembly 0.058568 1.232
R-HSA-69473 G2/M DNA damage checkpoint 0.044032 1.356
R-HSA-2467813 Separation of Sister Chromatids 0.096504 1.015
R-HSA-9686347 Microbial modulation of RIPK1-mediated regulated necrosis 0.090666 1.043
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.079709 1.098
R-HSA-3371556 Cellular response to heat stress 0.138226 0.859
R-HSA-75157 FasL/ CD95L signaling 0.046403 1.333
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.064359 1.191
R-HSA-164944 Nef and signal transduction 0.081980 1.086
R-HSA-448706 Interleukin-1 processing 0.107794 0.967
R-HSA-9005895 Pervasive developmental disorders 0.141095 0.850
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.141095 0.850
R-HSA-9697154 Disorders of Nervous System Development 0.141095 0.850
R-HSA-69190 DNA strand elongation 0.051234 1.290
R-HSA-190828 Gap junction trafficking 0.088163 1.055
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.093942 1.027
R-HSA-429914 Deadenylation-dependent mRNA decay 0.133834 0.873
R-HSA-68886 M Phase 0.091008 1.041
R-HSA-68882 Mitotic Anaphase 0.075697 1.121
R-HSA-3214841 PKMTs methylate histone lysines 0.076950 1.114
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.076755 1.115
R-HSA-75158 TRAIL signaling 0.073211 1.135
R-HSA-157858 Gap junction trafficking and regulation 0.102807 0.988
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.105167 0.978
R-HSA-9700206 Signaling by ALK in cancer 0.105167 0.978
R-HSA-1483249 Inositol phosphate metabolism 0.115131 0.939
R-HSA-162592 Integration of provirus 0.132887 0.877
R-HSA-180786 Extension of Telomeres 0.133834 0.873
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.076950 1.114
R-HSA-1592230 Mitochondrial biogenesis 0.037111 1.430
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 0.031521 1.501
R-HSA-5357801 Programmed Cell Death 0.064595 1.190
R-HSA-9662001 Defective factor VIII causes hemophilia A 0.081980 1.086
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.053712 1.270
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.111103 0.954
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.107131 0.970
R-HSA-166166 MyD88-independent TLR4 cascade 0.111103 0.954
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.101282 0.994
R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu... 0.081980 1.086
R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 0.090666 1.043
R-HSA-159740 Gamma-carboxylation of protein precursors 0.132887 0.877
R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 0.141095 0.850
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.099271 1.003
R-HSA-70326 Glucose metabolism 0.037111 1.430
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.086348 1.064
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.086348 1.064
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.086348 1.064
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.061200 1.213
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.109110 0.962
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.133914 0.873
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.046545 1.332
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.133914 0.873
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.140399 0.853
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.140399 0.853
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.053640 1.271
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.117166 0.931
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.123350 0.909
R-HSA-162582 Signal Transduction 0.063268 1.199
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.056084 1.251
R-HSA-192105 Synthesis of bile acids and bile salts 0.088160 1.055
R-HSA-8964539 Glutamate and glutamine metabolism 0.056084 1.251
R-HSA-194068 Bile acid and bile salt metabolism 0.111103 0.954
R-HSA-9007101 Rab regulation of trafficking 0.129651 0.887
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.035318 1.452
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.127467 0.895
R-HSA-157118 Signaling by NOTCH 0.103256 0.986
R-HSA-9692914 SARS-CoV-1-host interactions 0.103217 0.986
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.111891 0.951
R-HSA-5633007 Regulation of TP53 Activity 0.090799 1.042
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.149225 0.826
R-HSA-170660 Adenylate cyclase activating pathway 0.149225 0.826
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 0.157279 0.803
R-HSA-170670 Adenylate cyclase inhibitory pathway 0.165257 0.782
R-HSA-180336 SHC1 events in EGFR signaling 0.165257 0.782
R-HSA-6785631 ERBB2 Regulates Cell Motility 0.165257 0.782
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.173161 0.762
R-HSA-8854518 AURKA Activation by TPX2 0.156644 0.805
R-HSA-1643713 Signaling by EGFR in Cancer 0.262394 0.581
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.219042 0.659
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.219042 0.659
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.188745 0.724
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.188745 0.724
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.196427 0.707
R-HSA-156711 Polo-like kinase mediated events 0.196427 0.707
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.248216 0.605
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.283164 0.548
R-HSA-162594 Early Phase of HIV Life Cycle 0.219042 0.659
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.276306 0.559
R-HSA-156842 Eukaryotic Translation Elongation 0.252851 0.597
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.161563 0.792
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.262394 0.581
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.165257 0.782
R-HSA-1963640 GRB2 events in ERBB2 signaling 0.180989 0.742
R-HSA-164378 PKA activation in glucagon signalling 0.196427 0.707
R-HSA-350054 Notch-HLH transcription pathway 0.233767 0.631
R-HSA-933542 TRAF6 mediated NF-kB activation 0.248216 0.605
R-HSA-8949613 Cristae formation 0.269383 0.570
R-HSA-1963642 PI3K events in ERBB2 signaling 0.188745 0.724
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.269383 0.570
R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.211575 0.675
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.262394 0.581
R-HSA-9707616 Heme signaling 0.143516 0.843
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 0.204037 0.690
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.219042 0.659
R-HSA-420029 Tight junction interactions 0.255338 0.593
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.217931 0.662
R-HSA-162587 HIV Life Cycle 0.232486 0.634
R-HSA-162906 HIV Infection 0.209191 0.679
R-HSA-163615 PKA activation 0.196427 0.707
R-HSA-429947 Deadenylation of mRNA 0.248216 0.605
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.255338 0.593
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.186923 0.728
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.249176 0.603
R-HSA-8876725 Protein methylation 0.165257 0.782
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.270383 0.568
R-HSA-9612973 Autophagy 0.229988 0.638
R-HSA-69481 G2/M Checkpoints 0.153677 0.813
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.165257 0.782
R-HSA-2028269 Signaling by Hippo 0.188745 0.724
R-HSA-5578749 Transcriptional regulation by small RNAs 0.176731 0.753
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.217931 0.662
R-HSA-9663891 Selective autophagy 0.235353 0.628
R-HSA-9758274 Regulation of NF-kappa B signaling 0.173161 0.762
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.196427 0.707
R-HSA-6794362 Protein-protein interactions at synapses 0.221407 0.655
R-HSA-438064 Post NMDA receptor activation events 0.231861 0.635
R-HSA-418555 G alpha (s) signalling events 0.270472 0.568
R-HSA-397014 Muscle contraction 0.180350 0.744
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 0.219042 0.659
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.262394 0.581
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.204081 0.690
R-HSA-1852241 Organelle biogenesis and maintenance 0.223343 0.651
R-HSA-198753 ERK/MAPK targets 0.219042 0.659
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.219042 0.659
R-HSA-1236394 Signaling by ERBB4 0.183516 0.736
R-HSA-162599 Late Phase of HIV Life Cycle 0.195635 0.709
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.283164 0.548
R-HSA-157579 Telomere Maintenance 0.273889 0.562
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.263369 0.579
R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 0.180989 0.742
R-HSA-210991 Basigin interactions 0.219042 0.659
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.180989 0.742
R-HSA-445144 Signal transduction by L1 0.211575 0.675
R-HSA-9734767 Developmental Cell Lineages 0.282841 0.548
R-HSA-9671793 Diseases of hemostasis 0.204037 0.690
R-HSA-9706369 Negative regulation of FLT3 0.173161 0.762
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.241026 0.618
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.169988 0.770
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.210205 0.677
R-HSA-417957 P2Y receptors 0.157279 0.803
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.233767 0.631
R-HSA-9757110 Prednisone ADME 0.276306 0.559
R-HSA-72306 tRNA processing 0.267915 0.572
R-HSA-418038 Nucleotide-like (purinergic) receptors 0.196427 0.707
R-HSA-175474 Assembly Of The HIV Virion 0.226439 0.645
R-HSA-73884 Base Excision Repair 0.242346 0.616
R-HSA-844456 The NLRP3 inflammasome 0.204037 0.690
R-HSA-1834941 STING mediated induction of host immune responses 0.204037 0.690
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.241026 0.618
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.150050 0.824
R-HSA-622312 Inflammasomes 0.276306 0.559
R-HSA-975634 Retinoid metabolism and transport 0.173355 0.761
R-HSA-6806667 Metabolism of fat-soluble vitamins 0.207535 0.683
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.153340 0.814
R-HSA-2187338 Visual phototransduction 0.207759 0.682
R-HSA-9020591 Interleukin-12 signaling 0.190338 0.720
R-HSA-9678108 SARS-CoV-1 Infection 0.280729 0.552
R-HSA-447115 Interleukin-12 family signaling 0.231861 0.635
R-HSA-9020702 Interleukin-1 signaling 0.287906 0.541
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.289958 0.538
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.289958 0.538
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.289958 0.538
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.289958 0.538
R-HSA-8863795 Downregulation of ERBB2 signaling 0.289958 0.538
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.289958 0.538
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.291406 0.536
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.291406 0.536
R-HSA-73894 DNA Repair 0.294666 0.531
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.296687 0.528
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.296687 0.528
R-HSA-182971 EGFR downregulation 0.296687 0.528
R-HSA-162588 Budding and maturation of HIV virion 0.296687 0.528
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 0.296687 0.528
R-HSA-9860931 Response of endothelial cells to shear stress 0.298400 0.525
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.301894 0.520
R-HSA-5619507 Activation of HOX genes during differentiation 0.301894 0.520
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.303354 0.518
R-HSA-199991 Membrane Trafficking 0.304354 0.517
R-HSA-5696398 Nucleotide Excision Repair 0.305384 0.515
R-HSA-1855170 IPs transport between nucleus and cytosol 0.309957 0.509
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.309957 0.509
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.309957 0.509
R-HSA-354192 Integrin signaling 0.309957 0.509
R-HSA-176187 Activation of ATR in response to replication stress 0.309957 0.509
R-HSA-5675482 Regulation of necroptotic cell death 0.309957 0.509
R-HSA-9022692 Regulation of MECP2 expression and activity 0.309957 0.509
R-HSA-69239 Synthesis of DNA 0.312355 0.505
R-HSA-211000 Gene Silencing by RNA 0.312355 0.505
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.316498 0.500
R-HSA-163359 Glucagon signaling in metabolic regulation 0.316498 0.500
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.316498 0.500
R-HSA-168898 Toll-like Receptor Cascades 0.322034 0.492
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 0.322978 0.491
R-HSA-5365859 RA biosynthesis pathway 0.322978 0.491
R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 0.322978 0.491
R-HSA-168638 NOD1/2 Signaling Pathway 0.322978 0.491
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.329397 0.482
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.329397 0.482
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.329397 0.482
R-HSA-9609690 HCMV Early Events 0.334977 0.475
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.335755 0.474
R-HSA-3371511 HSF1 activation 0.335755 0.474
R-HSA-111933 Calmodulin induced events 0.335755 0.474
R-HSA-111997 CaM pathway 0.335755 0.474
R-HSA-8853659 RET signaling 0.335755 0.474
R-HSA-9855142 Cellular responses to mechanical stimuli 0.336628 0.473
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.339241 0.469
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.340076 0.468
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.342053 0.466
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.342053 0.466
R-HSA-549127 SLC-mediated transport of organic cations 0.342053 0.466
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.342053 0.466
R-HSA-196757 Metabolism of folate and pterines 0.342053 0.466
R-HSA-6785470 tRNA processing in the mitochondrion 0.348292 0.458
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.348292 0.458
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.348292 0.458
R-HSA-9675108 Nervous system development 0.349455 0.457
R-HSA-373760 L1CAM interactions 0.350388 0.455
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.354472 0.450
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.354472 0.450
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.360594 0.443
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.360594 0.443
R-HSA-1251985 Nuclear signaling by ERBB4 0.360594 0.443
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.360594 0.443
R-HSA-5260271 Diseases of Immune System 0.360594 0.443
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.360594 0.443
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.366658 0.436
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.366658 0.436
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.366658 0.436
R-HSA-9607240 FLT3 Signaling 0.366658 0.436
R-HSA-73886 Chromosome Maintenance 0.367451 0.435
R-HSA-5674135 MAP2K and MAPK activation 0.372665 0.429
R-HSA-9656223 Signaling by RAF1 mutants 0.372665 0.429
R-HSA-991365 Activation of GABAB receptors 0.378616 0.422
R-HSA-977444 GABA B receptor activation 0.378616 0.422
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.378616 0.422
R-HSA-111996 Ca-dependent events 0.378616 0.422
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.378836 0.422
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.384340 0.415
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.384340 0.415
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.384340 0.415
R-HSA-9637690 Response of Mtb to phagocytosis 0.384510 0.415
R-HSA-5683826 Surfactant metabolism 0.390349 0.409
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.396133 0.402
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.396133 0.402
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.396133 0.402
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.396133 0.402
R-HSA-1489509 DAG and IP3 signaling 0.396133 0.402
R-HSA-8951664 Neddylation 0.401838 0.396
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.401862 0.396
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.401862 0.396
R-HSA-9649948 Signaling downstream of RAS mutants 0.401862 0.396
R-HSA-6802949 Signaling by RAS mutants 0.401862 0.396
R-HSA-5357905 Regulation of TNFR1 signaling 0.401862 0.396
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.401862 0.396
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.401862 0.396
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.401862 0.396
R-HSA-437239 Recycling pathway of L1 0.407538 0.390
R-HSA-9909396 Circadian clock 0.410951 0.386
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.413159 0.384
R-HSA-9634597 GPER1 signaling 0.413159 0.384
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.413159 0.384
R-HSA-8957322 Metabolism of steroids 0.413322 0.384
R-HSA-449147 Signaling by Interleukins 0.416265 0.381
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.418728 0.378
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0.424245 0.372
R-HSA-912446 Meiotic recombination 0.429709 0.367
R-HSA-2514856 The phototransduction cascade 0.429709 0.367
R-HSA-3247509 Chromatin modifying enzymes 0.434627 0.362
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.440483 0.356
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.440483 0.356
R-HSA-445355 Smooth Muscle Contraction 0.440483 0.356
R-HSA-1632852 Macroautophagy 0.443406 0.353
R-HSA-72649 Translation initiation complex formation 0.445795 0.351
R-HSA-3214815 HDACs deacetylate histones 0.451056 0.346
R-HSA-418597 G alpha (z) signalling events 0.451056 0.346
R-HSA-8856828 Clathrin-mediated endocytosis 0.452952 0.344
R-HSA-72702 Ribosomal scanning and start codon recognition 0.456267 0.341
R-HSA-75893 TNF signaling 0.456267 0.341
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.456267 0.341
R-HSA-5578775 Ion homeostasis 0.456267 0.341
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.456267 0.341
R-HSA-2980766 Nuclear Envelope Breakdown 0.461429 0.336
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.466543 0.331
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.466543 0.331
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.466543 0.331
R-HSA-69242 S Phase 0.468654 0.329
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.471608 0.326
R-HSA-191859 snRNP Assembly 0.471608 0.326
R-HSA-194441 Metabolism of non-coding RNA 0.471608 0.326
R-HSA-4839726 Chromatin organization 0.471620 0.326
R-HSA-9609646 HCMV Infection 0.474049 0.324
R-HSA-1227986 Signaling by ERBB2 0.476626 0.322
R-HSA-977443 GABA receptor activation 0.476626 0.322
R-HSA-983189 Kinesins 0.476626 0.322
R-HSA-156590 Glutathione conjugation 0.476626 0.322
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.476626 0.322
R-HSA-5362517 Signaling by Retinoic Acid 0.476626 0.322
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.476626 0.322
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.476626 0.322
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.476626 0.322
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.476626 0.322
R-HSA-446652 Interleukin-1 family signaling 0.481022 0.318
R-HSA-168325 Viral Messenger RNA Synthesis 0.481596 0.317
R-HSA-445717 Aquaporin-mediated transport 0.481596 0.317
R-HSA-450294 MAP kinase activation 0.481596 0.317
R-HSA-112043 PLC beta mediated events 0.481596 0.317
R-HSA-69306 DNA Replication 0.484087 0.315
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.486520 0.313
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.487141 0.312
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.487141 0.312
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.491396 0.309
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.491396 0.309
R-HSA-3700989 Transcriptional Regulation by TP53 0.491842 0.308
R-HSA-936837 Ion transport by P-type ATPases 0.496227 0.304
R-HSA-112316 Neuronal System 0.497251 0.303
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.501013 0.300
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.505753 0.296
R-HSA-5693606 DNA Double Strand Break Response 0.510448 0.292
R-HSA-112040 G-protein mediated events 0.510448 0.292
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.515099 0.288
R-HSA-5218859 Regulated Necrosis 0.515099 0.288
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.515099 0.288
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.524270 0.280
R-HSA-448424 Interleukin-17 signaling 0.524270 0.280
R-HSA-5619102 SLC transporter disorders 0.525801 0.279
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.528791 0.277
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.528791 0.277
R-HSA-453276 Regulation of mitotic cell cycle 0.528791 0.277
R-HSA-76002 Platelet activation, signaling and aggregation 0.530716 0.275
R-HSA-5653656 Vesicle-mediated transport 0.532976 0.273
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.533269 0.273
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.533269 0.273
R-HSA-74259 Purine catabolism 0.533269 0.273
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.537704 0.269
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.537704 0.269
R-HSA-5621481 C-type lectin receptors (CLRs) 0.540143 0.267
R-HSA-9013694 Signaling by NOTCH4 0.542098 0.266
R-HSA-380287 Centrosome maturation 0.546450 0.262
R-HSA-1169408 ISG15 antiviral mechanism 0.546450 0.262
R-HSA-9824443 Parasitic Infection Pathways 0.546603 0.262
R-HSA-9658195 Leishmania infection 0.546603 0.262
R-HSA-1980143 Signaling by NOTCH1 0.550761 0.259
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.551401 0.259
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.555032 0.256
R-HSA-383280 Nuclear Receptor transcription pathway 0.559262 0.252
R-HSA-168255 Influenza Infection 0.562466 0.250
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.563452 0.249
R-HSA-5673001 RAF/MAP kinase cascade 0.564375 0.248
R-HSA-2559583 Cellular Senescence 0.565202 0.248
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.567603 0.246
R-HSA-9833482 PKR-mediated signaling 0.567603 0.246
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.575787 0.240
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.575787 0.240
R-HSA-5684996 MAPK1/MAPK3 signaling 0.579577 0.237
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.579821 0.237
R-HSA-9707564 Cytoprotection by HMOX1 0.579821 0.237
R-HSA-6802957 Oncogenic MAPK signaling 0.587775 0.231
R-HSA-1500620 Meiosis 0.587775 0.231
R-HSA-983712 Ion channel transport 0.589273 0.230
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.595579 0.225
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.597076 0.224
R-HSA-1280215 Cytokine Signaling in Immune system 0.597420 0.224
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.603237 0.220
R-HSA-156902 Peptide chain elongation 0.603237 0.220
R-HSA-9645723 Diseases of programmed cell death 0.603237 0.220
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.610751 0.214
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.614454 0.212
R-HSA-8986944 Transcriptional Regulation by MECP2 0.614454 0.212
R-HSA-389948 Co-inhibition by PD-1 0.617343 0.209
R-HSA-72766 Translation 0.621721 0.206
R-HSA-376176 Signaling by ROBO receptors 0.624740 0.204
R-HSA-422475 Axon guidance 0.627094 0.203
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.628922 0.201
R-HSA-9837999 Mitochondrial protein degradation 0.628922 0.201
R-HSA-1474290 Collagen formation 0.628922 0.201
R-HSA-388396 GPCR downstream signalling 0.634466 0.198
R-HSA-112315 Transmission across Chemical Synapses 0.635031 0.197
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.639418 0.194
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.639418 0.194
R-HSA-9679506 SARS-CoV Infections 0.642441 0.192
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.642850 0.192
R-HSA-8957275 Post-translational protein phosphorylation 0.646251 0.190
R-HSA-422356 Regulation of insulin secretion 0.646251 0.190
R-HSA-9730414 MITF-M-regulated melanocyte development 0.650923 0.186
R-HSA-5610787 Hedgehog 'off' state 0.652955 0.185
R-HSA-9009391 Extra-nuclear estrogen signaling 0.656259 0.183
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.665336 0.177
R-HSA-111885 Opioid Signalling 0.665986 0.177
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.665986 0.177
R-HSA-6798695 Neutrophil degranulation 0.668547 0.175
R-HSA-8953897 Cellular responses to stimuli 0.676354 0.170
R-HSA-5683057 MAPK family signaling cascades 0.679927 0.168
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.681595 0.166
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.681595 0.166
R-HSA-2672351 Stimuli-sensing channels 0.681595 0.166
R-HSA-9705683 SARS-CoV-2-host interactions 0.684278 0.165
R-HSA-202403 TCR signaling 0.687633 0.163
R-HSA-1280218 Adaptive Immune System 0.690547 0.161
R-HSA-202733 Cell surface interactions at the vascular wall 0.703020 0.153
R-HSA-1643685 Disease 0.704644 0.152
R-HSA-9006931 Signaling by Nuclear Receptors 0.707531 0.150
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.707885 0.150
R-HSA-196854 Metabolism of vitamins and cofactors 0.709194 0.149
R-HSA-72613 Eukaryotic Translation Initiation 0.710670 0.148
R-HSA-72737 Cap-dependent Translation Initiation 0.710670 0.148
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.716160 0.145
R-HSA-68875 Mitotic Prophase 0.721547 0.142
R-HSA-5619115 Disorders of transmembrane transporters 0.722758 0.141
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.723519 0.141
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.724202 0.140
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.729437 0.137
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.729437 0.137
R-HSA-2132295 MHC class II antigen presentation 0.729437 0.137
R-HSA-6809371 Formation of the cornified envelope 0.732018 0.135
R-HSA-372790 Signaling by GPCR 0.733937 0.134
R-HSA-977606 Regulation of Complement cascade 0.734574 0.134
R-HSA-194138 Signaling by VEGF 0.737106 0.132
R-HSA-388841 Regulation of T cell activation by CD28 family 0.739572 0.131
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.739613 0.131
R-HSA-114608 Platelet degranulation 0.742097 0.130
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.744558 0.128
R-HSA-8956319 Nucleotide catabolism 0.746995 0.127
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.749409 0.125
R-HSA-1474165 Reproduction 0.751800 0.124
R-HSA-9843745 Adipogenesis 0.754169 0.123
R-HSA-5576891 Cardiac conduction 0.754169 0.123
R-HSA-8856688 Golgi-to-ER retrograde transport 0.756515 0.121
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.758839 0.120
R-HSA-9711123 Cellular response to chemical stress 0.760639 0.119
R-HSA-163685 Integration of energy metabolism 0.767916 0.115
R-HSA-9824446 Viral Infection Pathways 0.769481 0.114
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.770131 0.113
R-HSA-9948299 Ribosome-associated quality control 0.772326 0.112
R-HSA-5358351 Signaling by Hedgehog 0.772326 0.112
R-HSA-9664407 Parasite infection 0.776653 0.110
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.776653 0.110
R-HSA-9664417 Leishmania phagocytosis 0.776653 0.110
R-HSA-2262752 Cellular responses to stress 0.776960 0.110
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.778648 0.109
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.778786 0.109
R-HSA-1266738 Developmental Biology 0.781675 0.107
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.782991 0.106
R-HSA-166658 Complement cascade 0.789150 0.103
R-HSA-166520 Signaling by NTRKs 0.795136 0.100
R-HSA-9856651 MITF-M-dependent gene expression 0.799032 0.097
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.800952 0.096
R-HSA-2142753 Arachidonate metabolism 0.802855 0.095
R-HSA-73887 Death Receptor Signaling 0.806605 0.093
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.808453 0.092
R-HSA-1989781 PPARA activates gene expression 0.808453 0.092
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.812098 0.090
R-HSA-9610379 HCMV Late Events 0.812098 0.090
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.813894 0.089
R-HSA-9006936 Signaling by TGFB family members 0.817436 0.088
R-HSA-8953854 Metabolism of RNA 0.828061 0.082
R-HSA-168249 Innate Immune System 0.834005 0.079
R-HSA-5663205 Infectious disease 0.838569 0.076
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.838880 0.076
R-HSA-212165 Epigenetic regulation of gene expression 0.839366 0.076
R-HSA-9664433 Leishmania parasite growth and survival 0.840421 0.076
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.840421 0.076
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.841949 0.075
R-HSA-201681 TCF dependent signaling in response to WNT 0.855056 0.068
R-HSA-375276 Peptide ligand-binding receptors 0.859181 0.066
R-HSA-168256 Immune System 0.860018 0.065
R-HSA-9006925 Intracellular signaling by second messengers 0.860618 0.065
R-HSA-5617833 Cilium Assembly 0.864499 0.063
R-HSA-9694516 SARS-CoV-2 Infection 0.867781 0.062
R-HSA-72163 mRNA Splicing - Major Pathway 0.869618 0.061
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.876939 0.057
R-HSA-72172 mRNA Splicing 0.882726 0.054
R-HSA-597592 Post-translational protein modification 0.884551 0.053
R-HSA-109582 Hemostasis 0.884680 0.053
R-HSA-6805567 Keratinization 0.884964 0.053
R-HSA-9748784 Drug ADME 0.897531 0.047
R-HSA-913531 Interferon Signaling 0.898803 0.046
R-HSA-8878171 Transcriptional regulation by RUNX1 0.905141 0.043
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.907068 0.042
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.908733 0.042
R-HSA-425407 SLC-mediated transmembrane transport 0.909211 0.041
R-HSA-15869 Metabolism of nucleotides 0.913869 0.039
R-HSA-8939211 ESR-mediated signaling 0.914696 0.039
R-HSA-156580 Phase II - Conjugation of compounds 0.916328 0.038
R-HSA-421270 Cell-cell junction organization 0.925486 0.034
R-HSA-392499 Metabolism of proteins 0.936555 0.028
R-HSA-212436 Generic Transcription Pathway 0.938073 0.028
R-HSA-446728 Cell junction organization 0.942612 0.026
R-HSA-74160 Gene expression (Transcription) 0.948515 0.023
R-HSA-1257604 PIP3 activates AKT signaling 0.951325 0.022
R-HSA-195721 Signaling by WNT 0.952719 0.021
R-HSA-1500931 Cell-Cell communication 0.960293 0.018
R-HSA-382551 Transport of small molecules 0.964529 0.016
R-HSA-1474244 Extracellular matrix organization 0.965674 0.015
R-HSA-73857 RNA Polymerase II Transcription 0.969749 0.013
R-HSA-9824439 Bacterial Infection Pathways 0.980856 0.008
R-HSA-500792 GPCR ligand binding 0.980920 0.008
R-HSA-418594 G alpha (i) signalling events 0.983781 0.007
R-HSA-8978868 Fatty acid metabolism 0.983781 0.007
R-HSA-71291 Metabolism of amino acids and derivatives 0.985067 0.007
R-HSA-211859 Biological oxidations 0.994795 0.002
R-HSA-556833 Metabolism of lipids 0.999045 0.000
R-HSA-9709957 Sensory Perception 0.999616 0.000
R-HSA-1430728 Metabolism 0.999965 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
PRKD2PRKD2 0.840 0.266 -3 0.624
RSK2RSK2 0.835 0.178 -3 0.572
PRKD1PRKD1 0.833 0.187 -3 0.581
RSK3RSK3 0.831 0.144 -3 0.557
TSSK1TSSK1 0.830 0.302 -3 0.682
PAK6PAK6 0.830 0.330 -2 0.758
NDR2NDR2 0.830 0.186 -3 0.626
WNK1WNK1 0.830 0.285 -2 0.882
AURCAURC 0.830 0.239 -2 0.764
P90RSKP90RSK 0.829 0.131 -3 0.544
PRKD3PRKD3 0.829 0.203 -3 0.590
MNK2MNK2 0.828 0.302 -2 0.855
COTCOT 0.828 0.064 2 0.876
NUAK2NUAK2 0.828 0.221 -3 0.667
NDR1NDR1 0.828 0.197 -3 0.633
CAMK1BCAMK1B 0.827 0.202 -3 0.638
PKG2PKG2 0.826 0.250 -2 0.782
SKMLCKSKMLCK 0.826 0.258 -2 0.886
PKACGPKACG 0.826 0.215 -2 0.818
MAPKAPK3MAPKAPK3 0.826 0.165 -3 0.592
AMPKA1AMPKA1 0.826 0.253 -3 0.670
PKN2PKN2 0.825 0.219 -3 0.653
P70S6KBP70S6KB 0.824 0.190 -3 0.611
MNK1MNK1 0.824 0.332 -2 0.856
AURBAURB 0.824 0.220 -2 0.753
PKN3PKN3 0.824 0.121 -3 0.599
CAMK4CAMK4 0.823 0.265 -3 0.674
CLK3CLK3 0.823 0.202 1 0.785
PIM3PIM3 0.823 0.112 -3 0.598
MELKMELK 0.823 0.244 -3 0.656
AMPKA2AMPKA2 0.822 0.235 -3 0.663
MST4MST4 0.822 0.207 2 0.854
RIPK3RIPK3 0.822 0.115 3 0.831
TSSK2TSSK2 0.822 0.217 -5 0.858
NUAK1NUAK1 0.821 0.187 -3 0.645
TBK1TBK1 0.821 0.047 1 0.806
CAMLCKCAMLCK 0.821 0.178 -2 0.875
RSK4RSK4 0.821 0.170 -3 0.555
LATS2LATS2 0.820 0.162 -5 0.728
CLK1CLK1 0.820 0.194 -3 0.616
PKCDPKCD 0.820 0.177 2 0.800
CDC7CDC7 0.820 -0.011 1 0.827
PRPKPRPK 0.819 -0.019 -1 0.817
TGFBR2TGFBR2 0.819 0.038 -2 0.774
PAK3PAK3 0.819 0.200 -2 0.817
RAF1RAF1 0.819 0.079 1 0.876
SGK3SGK3 0.818 0.206 -3 0.589
PIM1PIM1 0.818 0.151 -3 0.589
PAK1PAK1 0.818 0.204 -2 0.823
PKACBPKACB 0.817 0.216 -2 0.778
NLKNLK 0.817 0.038 1 0.803
MAPKAPK2MAPKAPK2 0.817 0.119 -3 0.552
MYLK4MYLK4 0.817 0.182 -2 0.824
WNK3WNK3 0.817 0.122 1 0.832
GCN2GCN2 0.816 -0.105 2 0.831
CAMK2DCAMK2D 0.816 0.118 -3 0.619
NIKNIK 0.816 0.232 -3 0.656
DAPK2DAPK2 0.816 0.176 -3 0.626
IKKEIKKE 0.816 0.005 1 0.809
ULK2ULK2 0.814 -0.088 2 0.831
PKACAPKACA 0.814 0.209 -2 0.741
CDKL1CDKL1 0.814 0.010 -3 0.536
PHKG1PHKG1 0.814 0.159 -3 0.652
CLK4CLK4 0.814 0.157 -3 0.595
PHKG2PHKG2 0.814 0.266 -3 0.708
PRKXPRKX 0.813 0.240 -3 0.601
CDKL5CDKL5 0.813 0.025 -3 0.526
AKT2AKT2 0.813 0.140 -3 0.543
PDHK1PDHK1 0.812 -0.053 1 0.865
MARK4MARK4 0.812 0.081 4 0.781
ERK5ERK5 0.811 0.010 1 0.745
MSK1MSK1 0.811 0.111 -3 0.519
MOSMOS 0.811 -0.022 1 0.825
PDHK4PDHK4 0.811 -0.155 1 0.861
HIPK4HIPK4 0.810 0.039 1 0.728
AKT1AKT1 0.810 0.181 -3 0.575
IKKBIKKB 0.810 -0.072 -2 0.690
BMPR2BMPR2 0.810 -0.114 -2 0.845
HUNKHUNK 0.810 -0.033 2 0.860
DCAMKL1DCAMKL1 0.810 0.266 -3 0.671
DCAMKL2DCAMKL2 0.809 0.259 -3 0.694
CHK1CHK1 0.809 0.220 -3 0.646
BRSK2BRSK2 0.809 0.153 -3 0.660
ICKICK 0.808 0.048 -3 0.566
RIPK1RIPK1 0.808 0.029 1 0.830
MSK2MSK2 0.808 0.044 -3 0.496
DSTYKDSTYK 0.808 -0.095 2 0.850
PAK2PAK2 0.808 0.146 -2 0.804
P70S6KP70S6K 0.808 0.124 -3 0.526
AURAAURA 0.808 0.145 -2 0.716
CAMK2GCAMK2G 0.807 -0.036 2 0.802
QSKQSK 0.807 0.119 4 0.759
SRPK1SRPK1 0.807 0.028 -3 0.509
SIKSIK 0.807 0.130 -3 0.622
PKCAPKCA 0.807 0.111 2 0.740
CHAK2CHAK2 0.807 0.017 -1 0.827
QIKQIK 0.807 0.112 -3 0.649
BRSK1BRSK1 0.807 0.120 -3 0.628
NEK7NEK7 0.806 -0.123 -3 0.552
ATRATR 0.806 -0.029 1 0.809
NEK9NEK9 0.806 -0.038 2 0.863
PIM2PIM2 0.806 0.141 -3 0.576
PKCGPKCG 0.806 0.118 2 0.751
CAMK1DCAMK1D 0.806 0.186 -3 0.585
NIM1NIM1 0.805 0.013 3 0.815
NEK6NEK6 0.805 -0.085 -2 0.831
PAK5PAK5 0.805 0.230 -2 0.693
CAMK1GCAMK1G 0.805 0.110 -3 0.593
CAMK2BCAMK2B 0.805 0.122 2 0.752
PKCHPKCH 0.805 0.119 2 0.743
CAMK2ACAMK2A 0.804 0.116 2 0.766
MTORMTOR 0.804 -0.135 1 0.789
ULK1ULK1 0.804 -0.132 -3 0.532
SSTKSSTK 0.803 0.207 4 0.746
MLK1MLK1 0.803 -0.097 2 0.819
LATS1LATS1 0.803 0.150 -3 0.608
PAK4PAK4 0.803 0.212 -2 0.707
PKCBPKCB 0.803 0.102 2 0.740
SRPK2SRPK2 0.803 0.017 -3 0.463
BCKDKBCKDK 0.803 -0.074 -1 0.717
IRE1IRE1 0.802 -0.004 1 0.776
CAMK1ACAMK1A 0.800 0.161 -3 0.546
PKCZPKCZ 0.800 0.104 2 0.798
KISKIS 0.800 -0.014 1 0.641
IRE2IRE2 0.800 0.021 2 0.783
MARK3MARK3 0.799 0.106 4 0.728
GRK5GRK5 0.799 -0.132 -3 0.579
NEK2NEK2 0.799 -0.005 2 0.829
SMMLCKSMMLCK 0.799 0.143 -3 0.602
CHK2CHK2 0.799 0.132 -3 0.531
WNK4WNK4 0.799 0.132 -2 0.863
MASTLMASTL 0.799 -0.124 -2 0.772
ANKRD3ANKRD3 0.799 -0.051 1 0.873
IKKAIKKA 0.799 -0.041 -2 0.672
PKRPKR 0.798 0.073 1 0.830
SNRKSNRK 0.798 0.048 2 0.729
GRK6GRK6 0.798 -0.049 1 0.848
TTBK2TTBK2 0.798 -0.088 2 0.763
CLK2CLK2 0.798 0.140 -3 0.582
GRK1GRK1 0.798 -0.019 -2 0.717
PKN1PKN1 0.797 0.118 -3 0.571
MARK2MARK2 0.797 0.082 4 0.701
ALK4ALK4 0.797 0.010 -2 0.795
PKCTPKCT 0.797 0.109 2 0.754
MLK2MLK2 0.797 -0.064 2 0.829
IRAK4IRAK4 0.796 0.104 1 0.811
CDK7CDK7 0.796 0.007 1 0.616
PLK1PLK1 0.796 -0.025 -2 0.779
MRCKBMRCKB 0.796 0.215 -3 0.608
MAPKAPK5MAPKAPK5 0.796 -0.043 -3 0.482
AKT3AKT3 0.795 0.111 -3 0.471
PKG1PKG1 0.795 0.177 -2 0.716
TGFBR1TGFBR1 0.795 0.010 -2 0.770
ATMATM 0.794 -0.023 1 0.754
CHAK1CHAK1 0.794 -0.017 2 0.811
SGK1SGK1 0.794 0.112 -3 0.455
MARK1MARK1 0.794 0.088 4 0.745
MLK3MLK3 0.794 -0.037 2 0.746
SRPK3SRPK3 0.793 -0.017 -3 0.480
PKCIPKCI 0.793 0.116 2 0.765
MRCKAMRCKA 0.793 0.220 -3 0.614
GRK4GRK4 0.793 -0.125 -2 0.755
HIPK1HIPK1 0.793 0.053 1 0.659
CDK8CDK8 0.792 -0.034 1 0.617
DYRK1ADYRK1A 0.792 0.018 1 0.688
DYRK2DYRK2 0.792 -0.001 1 0.635
PKCEPKCE 0.792 0.138 2 0.737
DLKDLK 0.791 -0.121 1 0.855
ROCK2ROCK2 0.791 0.251 -3 0.626
VRK2VRK2 0.791 -0.060 1 0.855
DAPK3DAPK3 0.791 0.196 -3 0.634
BMPR1BBMPR1B 0.791 0.026 1 0.804
DMPK1DMPK1 0.790 0.275 -3 0.653
CDK19CDK19 0.790 -0.023 1 0.579
DRAK1DRAK1 0.789 0.027 1 0.798
HIPK3HIPK3 0.789 0.021 1 0.674
PLK4PLK4 0.789 -0.019 2 0.705
MEK1MEK1 0.788 -0.082 2 0.847
P38AP38A 0.788 0.011 1 0.646
HRIHRI 0.788 -0.062 -2 0.807
YSK4YSK4 0.788 -0.060 1 0.823
PERKPERK 0.787 -0.063 -2 0.792
ACVR2AACVR2A 0.787 -0.024 -2 0.747
PLK3PLK3 0.786 -0.057 2 0.777
HIPK2HIPK2 0.786 0.037 1 0.545
ACVR2BACVR2B 0.786 -0.019 -2 0.755
ALK2ALK2 0.785 -0.004 -2 0.777
MST3MST3 0.785 0.102 2 0.834
CDK18CDK18 0.785 0.003 1 0.545
SMG1SMG1 0.785 -0.039 1 0.757
DYRK3DYRK3 0.784 0.041 1 0.662
MLK4MLK4 0.784 -0.092 2 0.737
CDK5CDK5 0.784 0.002 1 0.628
DNAPKDNAPK 0.784 0.002 1 0.729
NEK5NEK5 0.784 -0.007 1 0.833
JNK2JNK2 0.783 0.012 1 0.577
CDK14CDK14 0.783 0.026 1 0.601
IRAK1IRAK1 0.783 -0.046 -1 0.737
TTBK1TTBK1 0.782 -0.068 2 0.698
CRIKCRIK 0.782 0.173 -3 0.534
DAPK1DAPK1 0.782 0.139 -3 0.603
BUB1BUB1 0.782 0.157 -5 0.810
BRAFBRAF 0.782 0.009 -4 0.801
CDK13CDK13 0.781 -0.045 1 0.592
MEKK1MEKK1 0.781 -0.086 1 0.838
DYRK1BDYRK1B 0.781 0.018 1 0.598
ERK1ERK1 0.781 -0.017 1 0.571
SBKSBK 0.781 0.064 -3 0.462
ERK2ERK2 0.780 -0.032 1 0.623
ROCK1ROCK1 0.780 0.219 -3 0.617
CDK9CDK9 0.780 -0.028 1 0.607
CK1ECK1E 0.779 -0.081 -3 0.369
GRK7GRK7 0.779 -0.016 1 0.765
P38BP38B 0.779 -0.005 1 0.574
PRP4PRP4 0.778 -0.047 -3 0.484
ZAKZAK 0.778 -0.088 1 0.830
TAO3TAO3 0.778 0.113 1 0.825
MEK5MEK5 0.778 -0.118 2 0.843
TLK2TLK2 0.778 -0.108 1 0.787
TAO2TAO2 0.777 0.113 2 0.852
NEK4NEK4 0.777 0.025 1 0.834
CDK12CDK12 0.777 -0.035 1 0.570
CDK17CDK17 0.777 -0.014 1 0.492
CDK10CDK10 0.777 0.046 1 0.583
LOKLOK 0.777 0.150 -2 0.771
GRK2GRK2 0.777 -0.068 -2 0.652
BMPR1ABMPR1A 0.777 0.013 1 0.786
JNK3JNK3 0.776 -0.029 1 0.600
P38GP38G 0.776 -0.015 1 0.493
MEKK2MEKK2 0.776 -0.080 2 0.828
DYRK4DYRK4 0.776 0.006 1 0.561
MEKK3MEKK3 0.776 -0.118 1 0.839
TLK1TLK1 0.776 -0.094 -2 0.779
FAM20CFAM20C 0.776 -0.061 2 0.513
MPSK1MPSK1 0.775 0.003 1 0.737
CDK1CDK1 0.775 -0.017 1 0.575
PASKPASK 0.775 0.024 -3 0.591
CDK2CDK2 0.774 -0.037 1 0.663
CK1G1CK1G1 0.773 -0.089 -3 0.346
NEK1NEK1 0.773 0.049 1 0.826
CK1A2CK1A2 0.773 -0.068 -3 0.338
PDK1PDK1 0.773 0.002 1 0.818
NEK11NEK11 0.772 -0.057 1 0.836
GAKGAK 0.772 0.051 1 0.820
P38DP38D 0.771 -0.003 1 0.504
CK1DCK1D 0.770 -0.083 -3 0.334
MEKK6MEKK6 0.770 -0.012 1 0.819
MAP3K15MAP3K15 0.769 0.001 1 0.810
MAKMAK 0.769 0.045 -2 0.786
NEK8NEK8 0.769 -0.108 2 0.839
LKB1LKB1 0.769 -0.046 -3 0.583
CDK16CDK16 0.769 -0.003 1 0.506
CDK3CDK3 0.769 0.012 1 0.508
RIPK2RIPK2 0.768 -0.069 1 0.793
PINK1PINK1 0.768 -0.202 1 0.765
HPK1HPK1 0.768 0.108 1 0.852
KHS1KHS1 0.768 0.152 1 0.841
MOKMOK 0.767 0.045 1 0.656
TNIKTNIK 0.767 0.068 3 0.858
CAMKK1CAMKK1 0.767 -0.142 -2 0.734
GCKGCK 0.766 0.076 1 0.849
HGKHGK 0.766 0.008 3 0.861
MINKMINK 0.765 0.008 1 0.850
LRRK2LRRK2 0.765 0.003 2 0.862
VRK1VRK1 0.765 -0.015 2 0.870
EEF2KEEF2K 0.765 -0.026 3 0.809
SLKSLK 0.765 0.082 -2 0.692
KHS2KHS2 0.764 0.146 1 0.852
PBKPBK 0.763 0.067 1 0.733
CAMKK2CAMKK2 0.763 -0.124 -2 0.742
GRK3GRK3 0.763 -0.081 -2 0.604
GSK3BGSK3B 0.763 -0.058 4 0.354
CDK4CDK4 0.763 0.000 1 0.552
NEK3NEK3 0.763 -0.052 1 0.800
YSK1YSK1 0.762 0.021 2 0.828
ERK7ERK7 0.762 -0.019 2 0.536
STK33STK33 0.761 -0.068 2 0.687
CDK6CDK6 0.759 -0.016 1 0.580
PLK2PLK2 0.759 -0.051 -3 0.524
HASPINHASPIN 0.759 0.081 -1 0.699
MST1MST1 0.759 -0.039 1 0.840
PDHK3_TYRPDHK3_TYR 0.759 0.149 4 0.830
MEK2MEK2 0.758 -0.133 2 0.835
MST2MST2 0.757 -0.127 1 0.851
TAK1TAK1 0.757 -0.102 1 0.842
LIMK2_TYRLIMK2_TYR 0.756 0.179 -3 0.646
GSK3AGSK3A 0.753 -0.066 4 0.369
TAO1TAO1 0.753 0.083 1 0.776
TESK1_TYRTESK1_TYR 0.752 0.051 3 0.879
TTKTTK 0.752 -0.007 -2 0.794
PKMYT1_TYRPKMYT1_TYR 0.751 -0.006 3 0.880
EPHA6EPHA6 0.751 0.054 -1 0.819
ROS1ROS1 0.750 0.059 3 0.850
RETRET 0.750 0.056 1 0.825
BIKEBIKE 0.750 0.036 1 0.691
JNK1JNK1 0.749 -0.054 1 0.551
TYRO3TYRO3 0.749 0.031 3 0.860
MST1RMST1R 0.749 0.030 3 0.876
EPHB4EPHB4 0.748 0.030 -1 0.821
JAK2JAK2 0.748 0.020 1 0.831
TYK2TYK2 0.748 0.021 1 0.827
CK2A2CK2A2 0.747 -0.044 1 0.672
MAP2K7_TYRMAP2K7_TYR 0.747 -0.068 2 0.867
ASK1ASK1 0.747 -0.037 1 0.798
TNK2TNK2 0.745 0.082 3 0.847
MYO3BMYO3B 0.745 -0.019 2 0.826
TNK1TNK1 0.744 0.112 3 0.845
PINK1_TYRPINK1_TYR 0.744 -0.057 1 0.822
MAP2K4_TYRMAP2K4_TYR 0.744 -0.090 -1 0.823
CSF1RCSF1R 0.744 -0.017 3 0.875
ABL2ABL2 0.744 0.010 -1 0.779
DDR1DDR1 0.743 0.046 4 0.753
LIMK1_TYRLIMK1_TYR 0.743 -0.042 2 0.869
AXLAXL 0.743 0.074 3 0.851
ABL1ABL1 0.742 0.002 -1 0.775
JAK1JAK1 0.742 0.041 1 0.797
OSR1OSR1 0.741 -0.085 2 0.827
PDHK4_TYRPDHK4_TYR 0.741 -0.042 2 0.865
MYO3AMYO3A 0.741 -0.020 1 0.820
BMPR2_TYRBMPR2_TYR 0.740 -0.089 -1 0.798
YANK3YANK3 0.740 -0.042 2 0.456
EPHB1EPHB1 0.739 -0.001 1 0.853
MAP2K6_TYRMAP2K6_TYR 0.739 -0.125 -1 0.815
PDGFRBPDGFRB 0.739 -0.007 3 0.873
AAK1AAK1 0.739 0.064 1 0.585
YES1YES1 0.739 -0.016 -1 0.833
EPHB3EPHB3 0.738 -0.001 -1 0.806
TNNI3K_TYRTNNI3K_TYR 0.738 0.027 1 0.816
MERTKMERTK 0.738 0.040 3 0.847
PDHK1_TYRPDHK1_TYR 0.738 -0.138 -1 0.834
DDR2DDR2 0.737 0.122 3 0.813
KDRKDR 0.737 0.015 3 0.846
HCKHCK 0.736 -0.047 -1 0.803
TXKTXK 0.736 0.006 1 0.830
ITKITK 0.736 -0.019 -1 0.780
ALKALK 0.736 0.013 3 0.810
CK2A1CK2A1 0.736 -0.063 1 0.658
INSRRINSRR 0.736 -0.024 3 0.815
FGRFGR 0.736 -0.059 1 0.833
EPHB2EPHB2 0.736 -0.012 -1 0.802
JAK3JAK3 0.735 -0.061 1 0.801
EPHA4EPHA4 0.735 -0.018 2 0.767
SRMSSRMS 0.735 -0.027 1 0.849
FLT3FLT3 0.735 -0.031 3 0.862
LTKLTK 0.735 0.019 3 0.825
EPHA1EPHA1 0.735 0.027 3 0.846
LCKLCK 0.734 -0.029 -1 0.801
TEKTEK 0.734 -0.035 3 0.813
TECTEC 0.734 -0.006 -1 0.747
FERFER 0.734 -0.082 1 0.845
NEK10_TYRNEK10_TYR 0.734 0.019 1 0.727
FGFR1FGFR1 0.734 -0.021 3 0.836
PDGFRAPDGFRA 0.734 -0.041 3 0.877
FGFR2FGFR2 0.733 -0.028 3 0.841
KITKIT 0.733 -0.066 3 0.866
EPHA7EPHA7 0.731 -0.003 2 0.782
PTK2BPTK2B 0.731 0.032 -1 0.776
BLKBLK 0.731 -0.021 -1 0.800
ALPHAK3ALPHAK3 0.730 -0.099 -1 0.739
BMXBMX 0.730 -0.021 -1 0.715
CK1ACK1A 0.730 -0.112 -3 0.266
BTKBTK 0.729 -0.079 -1 0.761
WEE1_TYRWEE1_TYR 0.727 -0.038 -1 0.735
NTRK1NTRK1 0.727 -0.068 -1 0.777
FRKFRK 0.727 -0.050 -1 0.810
STLK3STLK3 0.726 -0.142 1 0.800
METMET 0.726 -0.074 3 0.861
NTRK2NTRK2 0.726 -0.067 3 0.838
INSRINSR 0.725 -0.057 3 0.797
EPHA3EPHA3 0.724 -0.058 2 0.757
FLT4FLT4 0.722 -0.064 3 0.822
LYNLYN 0.722 -0.080 3 0.807
FYNFYN 0.722 -0.052 -1 0.776
PTK6PTK6 0.720 -0.135 -1 0.739
NTRK3NTRK3 0.719 -0.079 -1 0.736
FGFR3FGFR3 0.719 -0.069 3 0.819
ERBB2ERBB2 0.719 -0.123 1 0.779
EPHA5EPHA5 0.717 -0.040 2 0.750
FLT1FLT1 0.716 -0.111 -1 0.785
MATKMATK 0.715 -0.085 -1 0.703
EPHA8EPHA8 0.715 -0.069 -1 0.774
CSKCSK 0.715 -0.072 2 0.793
SRCSRC 0.714 -0.079 -1 0.785
CK1G3CK1G3 0.710 -0.115 -3 0.231
MUSKMUSK 0.709 -0.086 1 0.671
EPHA2EPHA2 0.709 -0.050 -1 0.746
IGF1RIGF1R 0.709 -0.070 3 0.740
FGFR4FGFR4 0.708 -0.081 -1 0.750
EGFREGFR 0.708 -0.091 1 0.693
PTK2PTK2 0.707 -0.029 -1 0.729
YANK2YANK2 0.701 -0.081 2 0.465
FESFES 0.699 -0.082 -1 0.698
SYKSYK 0.698 -0.093 -1 0.721
ERBB4ERBB4 0.696 -0.083 1 0.704
CK1G2CK1G2 0.684 -0.126 -3 0.300
ZAP70ZAP70 0.674 -0.110 -1 0.637