Motif 93 (n=145)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NC98 | CCDC88B | S600 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6NJT0 | UNCX | S449 | ochoa | Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) | Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). {ECO:0000250}. |
| A7KAX9 | ARHGAP32 | S1203 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A7KAX9 | ARHGAP32 | Y1612 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8MYZ6 | FOXO6 | S215 | ochoa | Forkhead box protein O6 | Transcriptional activator. {ECO:0000250}. |
| O00221 | NFKBIE | S183 | ochoa | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}. |
| O14526 | FCHO1 | S479 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14686 | KMT2D | S2414 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15085 | ARHGEF11 | S150 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15117 | FYB1 | S391 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15417 | TNRC18 | S1033 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15530 | PDPK1 | S64 | ochoa|psp | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| O43189 | PHF1 | S446 | ochoa | PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) | Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}. |
| O43426 | SYNJ1 | S1053 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43432 | EIF4G3 | S305 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O75151 | PHF2 | S905 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75376 | NCOR1 | S918 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94885 | SASH1 | S486 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94967 | WDR47 | S536 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O94979 | SEC31A | S934 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95677 | EYA4 | S139 | ochoa | Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}. |
| O96017 | CHEK2 | S73 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P10276 | RARA | S74 | psp | Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) | Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
| P10276 | RARA | S77 | psp | Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) | Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
| P13378 | HOXD8 | S181 | ochoa | Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P13631 | RARG | S79 | psp | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}. |
| P20749 | BCL3 | S402 | psp | B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}. |
| P20749 | BCL3 | S406 | psp | B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}. |
| P24928 | POLR2A | S1845 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P25054 | APC | S1774 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P31629 | HIVEP2 | S2059 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P32519 | ELF1 | S541 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P35548 | MSX2 | S123 | ochoa | Homeobox protein MSX-2 (Homeobox protein Hox-8) | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
| P43268 | ETV4 | S140 | ochoa | ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) | Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}. |
| P46108 | CRK | S74 | ochoa | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P46734 | MAP2K3 | S31 | ochoa | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P48436 | SOX9 | S228 | ochoa | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P48436 | SOX9 | S231 | ochoa | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P49756 | RBM25 | S642 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P50549 | ETV1 | S191 | ochoa|psp | ETS translocation variant 1 (Ets-related protein 81) | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}. |
| P51116 | FXR2 | S525 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51610 | HCFC1 | S1490 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| Q02078 | MEF2A | S192 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q03164 | KMT2A | S2151 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q06413 | MEF2C | S387 | psp | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q13495 | MAMLD1 | S450 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13671 | RIN1 | S258 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14766 | LTBP1 | S539 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15596 | NCOA2 | S469 | ochoa|psp | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15942 | ZYX | S202 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16799 | RTN1 | S327 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2KHM9 | KIAA0753 | S190 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
| Q2TAL5 | SMTNL2 | S269 | ochoa | Smoothelin-like protein 2 | None |
| Q3KQU3 | MAP7D1 | S576 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3MIN7 | RGL3 | S555 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q3MIN7 | RGL3 | S569 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q5JST6 | EFHC2 | S382 | ochoa | EF-hand domain-containing family member C2 | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}. |
| Q5SRE5 | NUP188 | S1708 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5SYE7 | NHSL1 | S930 | ochoa | NHS-like protein 1 | None |
| Q5VT06 | CEP350 | S2830 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT52 | RPRD2 | S473 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | S714 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q68EM7 | ARHGAP17 | S676 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6A1A2 | PDPK2P | S37 | ochoa | Putative 3-phosphoinositide-dependent protein kinase 2 (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase 2 pseudogene) | Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). {ECO:0000250}. |
| Q6K0P9 | PYHIN1 | S176 | ochoa | Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X) | Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}. |
| Q6NUJ5 | PWWP2B | S43 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6P1L5 | FAM117B | S136 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P9B9 | INTS5 | S279 | ochoa | Integrator complex subunit 5 (Int5) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q6VMQ6 | ATF7IP | S293 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZS17 | RIPOR1 | S401 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q70E73 | RAPH1 | S965 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7Z2Z1 | TICRR | S1125 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z422 | SZRD1 | S51 | ochoa | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | None |
| Q7Z6J0 | SH3RF1 | S127 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q7Z6Z7 | HUWE1 | S2735 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86SQ0 | PHLDB2 | S545 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86TC9 | MYPN | S561 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86UU1 | PHLDB1 | S381 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UW9 | DTX2 | S217 | ochoa | Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Q86UX7 | FERMT3 | S484 | ochoa|psp | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86VM9 | ZC3H18 | S791 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VZ6 | JAZF1 | S105 | ochoa | Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802) | Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}. |
| Q86X51 | EZHIP | S447 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86XN7 | PROSER1 | S269 | ochoa | Proline and serine-rich protein 1 | Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs). {ECO:0000269|PubMed:34667079}. |
| Q8IUC6 | TICAM1 | S343 | ochoa | TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta) | Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:35215908}. |
| Q8IW93 | ARHGEF19 | S101 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IWZ8 | SUGP1 | S338 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IY63 | AMOTL1 | S892 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IYN6 | UBALD2 | S116 | ochoa | UBA-like domain-containing protein 2 | None |
| Q8IYT8 | ULK2 | S771 | ochoa | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. |
| Q8IZD0 | SAMD14 | S108 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8IZD0 | SAMD14 | S279 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8IZD2 | KMT2E | S1444 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8IZP0 | ABI1 | S267 | psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N3L3 | TXLNB | S38 | ochoa | Beta-taxilin (Muscle-derived protein 77) (hMDP77) | Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}. |
| Q8N9N5 | BANP | T352 | psp | Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein) | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (By similarity). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest (By similarity). Plays a role in the regulation of alternative splicing (PubMed:26080397). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (PubMed:26080397). {ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625, ECO:0000269|PubMed:26080397}. |
| Q8NEA6 | GLIS3 | S580 | ochoa | Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) | Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}. |
| Q8NEM7 | SUPT20H | S487 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NEM7 | SUPT20H | S492 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NEN0 | ARMC2 | S93 | ochoa | Armadillo repeat-containing protein 2 | Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity). {ECO:0000250|UniProtKB:Q3URY6}. |
| Q8NEZ4 | KMT2C | S2937 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NEZ4 | KMT2C | S4300 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8WYL5 | SSH1 | S57 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92622 | RUBCN | S248 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q92817 | EVPL | S361 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
| Q92993 | KAT5 | S155 | ochoa | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}. |
| Q969S8 | HDAC10 | S373 | ochoa | Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}. |
| Q96F05 | C11orf24 | S278 | ochoa | Uncharacterized protein C11orf24 (Protein DM4E3) | None |
| Q96I24 | FUBP3 | S528 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96LJ8 | UBXN10 | S65 | ochoa | UBX domain-containing protein 10 (UBX domain-containing protein 3) | VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662). {ECO:0000269|PubMed:26389662}. |
| Q96N21 | TEPSIN | S412 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96RN5 | MED15 | S502 | ochoa | Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}. |
| Q99081 | TCF12 | Y277 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99990 | VGLL1 | S84 | psp | Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000269|PubMed:10518497}. |
| Q9BUJ2 | HNRNPUL1 | S751 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}. |
| Q9BWE0 | REPIN1 | S329 | ochoa | DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) | Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}. |
| Q9BX66 | SORBS1 | S242 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BZ71 | PITPNM3 | S504 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9C0D5 | TANC1 | S1497 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9GZU3 | TMEM39B | S53 | ochoa | Transmembrane protein 39B | May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}. |
| Q9H5Z6 | FAM124B | S294 | ochoa | Protein FAM124B | None |
| Q9H9D4 | ZNF408 | S311 | ochoa | Zinc finger protein 408 (PR domain zinc finger protein 17) | May be involved in transcriptional regulation. |
| Q9HCD6 | TANC2 | S1490 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NYL2 | MAP3K20 | S718 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P2F8 | SIPA1L2 | S1520 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UET6 | FTSJ1 | S258 | ochoa | tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) | Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). Requisite for faithful cytoplasmic translation (PubMed:32393790). Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Promotes translation efficiency of the UUU codon (PubMed:32558197). Plays a role in neurogenesis (PubMed:36720500). Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis (PubMed:33771871, PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:36720500). May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). {ECO:0000269|PubMed:25404562, ECO:0000269|PubMed:26310293, ECO:0000269|PubMed:32198346, ECO:0000269|PubMed:32393790, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36720500}. |
| Q9UGJ0 | PRKAG2 | S71 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
| Q9UGU5 | HMGXB4 | S497 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UJY5 | GGA1 | S480 | psp | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}. |
| Q9ULD9 | ZNF608 | S627 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULH1 | ASAP1 | S785 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULL0 | KIAA1210 | S1086 | ochoa | Acrosomal protein KIAA1210 | None |
| Q9ULU4 | ZMYND8 | S24 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULU4 | ZMYND8 | S797 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULV3 | CIZ1 | S878 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UPU9 | SAMD4A | S671 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9UQ35 | SRRM2 | S783 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2664 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQQ2 | SH2B3 | S520 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y4B5 | MTCL1 | S306 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y5V3 | MAGED1 | S322 | ochoa | Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}. |
| P35408 | PTGER4 | S460 | ELM | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P35658 | NUP214 | S661 | Sugiyama | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}. |
| Q96L34 | MARK4 | S429 | Sugiyama | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
| Q9P0L2 | MARK1 | S624 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3247509 | Chromatin modifying enzymes | 0.000021 | 4.687 |
| R-HSA-4839726 | Chromatin organization | 0.000034 | 4.462 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000311 | 3.508 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.000668 | 3.175 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.000668 | 3.175 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000595 | 3.226 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.000973 | 3.012 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.008903 | 2.050 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.002134 | 2.671 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.004306 | 2.366 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.004645 | 2.333 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.004645 | 2.333 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.005370 | 2.270 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.005370 | 2.270 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.005756 | 2.240 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.006578 | 2.182 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.008422 | 2.075 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.008925 | 2.049 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.008422 | 2.075 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.004736 | 2.325 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.007136 | 2.147 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.007466 | 2.127 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.003599 | 2.444 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.005756 | 2.240 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.006033 | 2.219 |
| R-HSA-9733709 | Cardiogenesis | 0.005370 | 2.270 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.006159 | 2.211 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.003745 | 2.427 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.008925 | 2.049 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.008925 | 2.049 |
| R-HSA-525793 | Myogenesis | 0.003104 | 2.508 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.007466 | 2.127 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.007935 | 2.100 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.006749 | 2.171 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.008692 | 2.061 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.008422 | 2.075 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.006848 | 2.164 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.005128 | 2.290 |
| R-HSA-212436 | Generic Transcription Pathway | 0.006680 | 2.175 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.009446 | 2.025 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.017727 | 1.751 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.018557 | 1.731 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.022743 | 1.643 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.015491 | 1.810 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.014929 | 1.826 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.020206 | 1.695 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.023625 | 1.627 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.023625 | 1.627 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.023625 | 1.627 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.023625 | 1.627 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.012314 | 1.910 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.012442 | 1.905 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.021480 | 1.668 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.015491 | 1.810 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.022743 | 1.643 |
| R-HSA-191859 | snRNP Assembly | 0.022743 | 1.643 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.023625 | 1.627 |
| R-HSA-3214847 | HATs acetylate histones | 0.017594 | 1.755 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.012941 | 1.888 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.021033 | 1.677 |
| R-HSA-198753 | ERK/MAPK targets | 0.023069 | 1.637 |
| R-HSA-450294 | MAP kinase activation | 0.024526 | 1.610 |
| R-HSA-211000 | Gene Silencing by RNA | 0.022680 | 1.644 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.023294 | 1.633 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.022505 | 1.648 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.023919 | 1.621 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.024554 | 1.610 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.024554 | 1.610 |
| R-HSA-9707616 | Heme signaling | 0.025445 | 1.594 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.025445 | 1.594 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.025854 | 1.587 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.026473 | 1.577 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.026519 | 1.576 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.037737 | 1.423 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.037737 | 1.423 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.037737 | 1.423 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.036760 | 1.435 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.030315 | 1.518 |
| R-HSA-9839394 | TGFBR3 expression | 0.031863 | 1.497 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.031344 | 1.504 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.033757 | 1.472 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.036760 | 1.435 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.033941 | 1.469 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.028207 | 1.550 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.033757 | 1.472 |
| R-HSA-448424 | Interleukin-17 signaling | 0.033456 | 1.476 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.040261 | 1.395 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.039694 | 1.401 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.035641 | 1.448 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.028577 | 1.544 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.041755 | 1.379 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.042624 | 1.370 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.043734 | 1.359 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.043734 | 1.359 |
| R-HSA-9909396 | Circadian clock | 0.044678 | 1.350 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.045993 | 1.337 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.047632 | 1.322 |
| R-HSA-354192 | Integrin signaling | 0.048170 | 1.317 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.052250 | 1.282 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.052632 | 1.279 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.054280 | 1.265 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.054280 | 1.265 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.069057 | 1.161 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.071923 | 1.143 |
| R-HSA-165158 | Activation of AKT2 | 0.060691 | 1.217 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.056343 | 1.249 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.060691 | 1.217 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.060691 | 1.217 |
| R-HSA-162587 | HIV Life Cycle | 0.073004 | 1.137 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.062733 | 1.203 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.070652 | 1.151 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.070978 | 1.149 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.057399 | 1.241 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.057235 | 1.242 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.064391 | 1.191 |
| R-HSA-166520 | Signaling by NTRKs | 0.062733 | 1.203 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.061348 | 1.212 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.069490 | 1.158 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.075086 | 1.124 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.075086 | 1.124 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.075086 | 1.124 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.085568 | 1.068 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.093714 | 1.028 |
| R-HSA-8875656 | MET receptor recycling | 0.093714 | 1.028 |
| R-HSA-170984 | ARMS-mediated activation | 0.101788 | 0.992 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.101788 | 0.992 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.109791 | 0.959 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.109791 | 0.959 |
| R-HSA-4839744 | Signaling by APC mutants | 0.117722 | 0.929 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.117722 | 0.929 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.117722 | 0.929 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.117722 | 0.929 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.125584 | 0.901 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.125584 | 0.901 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.125584 | 0.901 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.133376 | 0.875 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.133376 | 0.875 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.133376 | 0.875 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.133376 | 0.875 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.133376 | 0.875 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.133376 | 0.875 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.156341 | 0.806 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.156341 | 0.806 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.156341 | 0.806 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.193280 | 0.714 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.193280 | 0.714 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.193280 | 0.714 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.200473 | 0.698 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.200473 | 0.698 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.200473 | 0.698 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.200473 | 0.698 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.221671 | 0.654 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.228612 | 0.641 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.228612 | 0.641 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.151581 | 0.819 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.183103 | 0.737 |
| R-HSA-1989781 | PPARA activates gene expression | 0.202423 | 0.694 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.207005 | 0.684 |
| R-HSA-72172 | mRNA Splicing | 0.142168 | 0.847 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.124853 | 0.904 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.207602 | 0.683 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.125584 | 0.901 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.171314 | 0.766 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.200473 | 0.698 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.101788 | 0.992 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.171314 | 0.766 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.133376 | 0.875 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.197865 | 0.704 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.214668 | 0.668 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.109791 | 0.959 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.125584 | 0.901 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.125584 | 0.901 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.193280 | 0.714 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.167211 | 0.777 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.199206 | 0.701 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.156341 | 0.806 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.109719 | 0.960 |
| R-HSA-9843745 | Adipogenesis | 0.145515 | 0.837 |
| R-HSA-157118 | Signaling by NOTCH | 0.204626 | 0.689 |
| R-HSA-1483226 | Synthesis of PI | 0.117722 | 0.929 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.125584 | 0.901 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.125584 | 0.901 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.178701 | 0.748 |
| R-HSA-162906 | HIV Infection | 0.181161 | 0.742 |
| R-HSA-169893 | Prolonged ERK activation events | 0.163861 | 0.786 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.118409 | 0.927 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.156341 | 0.806 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.101788 | 0.992 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.193280 | 0.714 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.200473 | 0.698 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.120296 | 0.920 |
| R-HSA-444257 | RSK activation | 0.093714 | 1.028 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.101788 | 0.992 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.156341 | 0.806 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.163861 | 0.786 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.228612 | 0.641 |
| R-HSA-9609690 | HCMV Early Events | 0.127930 | 0.893 |
| R-HSA-9613354 | Lipophagy | 0.101788 | 0.992 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.117722 | 0.929 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.133376 | 0.875 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.133376 | 0.875 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.133376 | 0.875 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.141099 | 0.850 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.148754 | 0.828 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.163861 | 0.786 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.142353 | 0.847 |
| R-HSA-9609646 | HCMV Infection | 0.223255 | 0.651 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.156341 | 0.806 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.124295 | 0.906 |
| R-HSA-2028269 | Signaling by Hippo | 0.178701 | 0.748 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.084801 | 1.072 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.108513 | 0.965 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.101788 | 0.992 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.148754 | 0.828 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.186308 | 0.730 |
| R-HSA-8939211 | ESR-mediated signaling | 0.199131 | 0.701 |
| R-HSA-1266738 | Developmental Biology | 0.225727 | 0.646 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.117722 | 0.929 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.163861 | 0.786 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.130251 | 0.885 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.158146 | 0.801 |
| R-HSA-9610379 | HCMV Late Events | 0.207005 | 0.684 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.212208 | 0.673 |
| R-HSA-168255 | Influenza Infection | 0.102829 | 0.988 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.109887 | 0.959 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.141099 | 0.850 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.148754 | 0.828 |
| R-HSA-200425 | Carnitine shuttle | 0.228612 | 0.641 |
| R-HSA-194138 | Signaling by VEGF | 0.131232 | 0.882 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.127247 | 0.895 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.186023 | 0.730 |
| R-HSA-70171 | Glycolysis | 0.078309 | 1.106 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.186023 | 0.730 |
| R-HSA-162582 | Signal Transduction | 0.182667 | 0.738 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.076690 | 1.115 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.082153 | 1.085 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.081592 | 1.088 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.200473 | 0.698 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.179906 | 0.745 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.076607 | 1.116 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.182933 | 0.738 |
| R-HSA-68875 | Mitotic Prophase | 0.119413 | 0.923 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.117483 | 0.930 |
| R-HSA-72306 | tRNA processing | 0.090565 | 1.043 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.109091 | 0.962 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.116280 | 0.934 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.117483 | 0.930 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.123307 | 0.909 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.178701 | 0.748 |
| R-HSA-70326 | Glucose metabolism | 0.113661 | 0.944 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.123307 | 0.909 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.195971 | 0.708 |
| R-HSA-1500931 | Cell-Cell communication | 0.183738 | 0.736 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.173291 | 0.761 |
| R-HSA-3371556 | Cellular response to heat stress | 0.121354 | 0.916 |
| R-HSA-73887 | Death Receptor Signaling | 0.200141 | 0.699 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.101210 | 0.995 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.208949 | 0.680 |
| R-HSA-109581 | Apoptosis | 0.218562 | 0.660 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.228571 | 0.641 |
| R-HSA-5619102 | SLC transporter disorders | 0.230250 | 0.638 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.234643 | 0.630 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.242311 | 0.616 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.242311 | 0.616 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.242311 | 0.616 |
| R-HSA-3214842 | HDMs demethylate histones | 0.242311 | 0.616 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.242311 | 0.616 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.242311 | 0.616 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.244426 | 0.612 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.246803 | 0.608 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.246803 | 0.608 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.249070 | 0.604 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.249070 | 0.604 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.249070 | 0.604 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.251612 | 0.599 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.255768 | 0.592 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.255768 | 0.592 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.255768 | 0.592 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.255768 | 0.592 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.255768 | 0.592 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.255768 | 0.592 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.262408 | 0.581 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.262408 | 0.581 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.262408 | 0.581 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.262408 | 0.581 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.262408 | 0.581 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.268114 | 0.572 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.268988 | 0.570 |
| R-HSA-72086 | mRNA Capping | 0.268988 | 0.570 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.269310 | 0.570 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.275510 | 0.560 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.275510 | 0.560 |
| R-HSA-446728 | Cell junction organization | 0.277475 | 0.557 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.281975 | 0.550 |
| R-HSA-186763 | Downstream signal transduction | 0.281975 | 0.550 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.288382 | 0.540 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.288382 | 0.540 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.288382 | 0.540 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.294732 | 0.531 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.294732 | 0.531 |
| R-HSA-9930044 | Nuclear RNA decay | 0.294732 | 0.531 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.294732 | 0.531 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.294732 | 0.531 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.294732 | 0.531 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.294732 | 0.531 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.294732 | 0.531 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.294732 | 0.531 |
| R-HSA-202403 | TCR signaling | 0.297791 | 0.526 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.301026 | 0.521 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.301026 | 0.521 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.302245 | 0.520 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.307265 | 0.512 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.307265 | 0.512 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.307265 | 0.512 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.307265 | 0.512 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.307265 | 0.512 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.307265 | 0.512 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.311982 | 0.506 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.313448 | 0.504 |
| R-HSA-187687 | Signalling to ERKs | 0.313448 | 0.504 |
| R-HSA-195721 | Signaling by WNT | 0.317440 | 0.498 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.319576 | 0.495 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.319576 | 0.495 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.319576 | 0.495 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.325650 | 0.487 |
| R-HSA-5357801 | Programmed Cell Death | 0.326603 | 0.486 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.327286 | 0.485 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.330546 | 0.481 |
| R-HSA-8875878 | MET promotes cell motility | 0.331670 | 0.479 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.331670 | 0.479 |
| R-HSA-1566948 | Elastic fibre formation | 0.331670 | 0.479 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.333801 | 0.477 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.337636 | 0.472 |
| R-HSA-69541 | Stabilization of p53 | 0.337636 | 0.472 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.343550 | 0.464 |
| R-HSA-167169 | HIV Transcription Elongation | 0.343550 | 0.464 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.343550 | 0.464 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.343550 | 0.464 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.343550 | 0.464 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.343550 | 0.464 |
| R-HSA-5260271 | Diseases of Immune System | 0.343550 | 0.464 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.343550 | 0.464 |
| R-HSA-202433 | Generation of second messenger molecules | 0.343550 | 0.464 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.349411 | 0.457 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.349411 | 0.457 |
| R-HSA-9607240 | FLT3 Signaling | 0.349411 | 0.457 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.355221 | 0.450 |
| R-HSA-167161 | HIV Transcription Initiation | 0.355221 | 0.450 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.355221 | 0.450 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.355221 | 0.450 |
| R-HSA-8953854 | Metabolism of RNA | 0.358018 | 0.446 |
| R-HSA-418990 | Adherens junctions interactions | 0.358258 | 0.446 |
| R-HSA-165159 | MTOR signalling | 0.360979 | 0.443 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.360979 | 0.443 |
| R-HSA-69481 | G2/M Checkpoints | 0.362875 | 0.440 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.366685 | 0.436 |
| R-HSA-8854214 | TBC/RABGAPs | 0.366685 | 0.436 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.366685 | 0.436 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.366685 | 0.436 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.377947 | 0.423 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.377947 | 0.423 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.377947 | 0.423 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.383504 | 0.416 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.383504 | 0.416 |
| R-HSA-9675135 | Diseases of DNA repair | 0.383504 | 0.416 |
| R-HSA-75153 | Apoptotic execution phase | 0.383504 | 0.416 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.389011 | 0.410 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.394469 | 0.404 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.394469 | 0.404 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.394469 | 0.404 |
| R-HSA-9766229 | Degradation of CDH1 | 0.399878 | 0.398 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.399878 | 0.398 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.399878 | 0.398 |
| R-HSA-109704 | PI3K Cascade | 0.405240 | 0.392 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.405240 | 0.392 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.407111 | 0.390 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.410216 | 0.387 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.410216 | 0.387 |
| R-HSA-9664407 | Parasite infection | 0.410216 | 0.387 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.410554 | 0.387 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.413314 | 0.384 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.415821 | 0.381 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.415821 | 0.381 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.415821 | 0.381 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.420371 | 0.376 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.421041 | 0.376 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.421041 | 0.376 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.422558 | 0.374 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.427902 | 0.369 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.431343 | 0.365 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.436426 | 0.360 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.436426 | 0.360 |
| R-HSA-421270 | Cell-cell junction organization | 0.437326 | 0.359 |
| R-HSA-112399 | IRS-mediated signalling | 0.441463 | 0.355 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.441463 | 0.355 |
| R-HSA-73894 | DNA Repair | 0.442269 | 0.354 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.446456 | 0.350 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.446456 | 0.350 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.449834 | 0.347 |
| R-HSA-186712 | Regulation of beta-cell development | 0.451404 | 0.345 |
| R-HSA-2262752 | Cellular responses to stress | 0.452146 | 0.345 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.456308 | 0.341 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.461169 | 0.336 |
| R-HSA-211976 | Endogenous sterols | 0.461169 | 0.336 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.461169 | 0.336 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.461169 | 0.336 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.465987 | 0.332 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.465987 | 0.332 |
| R-HSA-186797 | Signaling by PDGF | 0.465987 | 0.332 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.470762 | 0.327 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.470762 | 0.327 |
| R-HSA-373755 | Semaphorin interactions | 0.470762 | 0.327 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.470762 | 0.327 |
| R-HSA-8848021 | Signaling by PTK6 | 0.470762 | 0.327 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.472179 | 0.326 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.475494 | 0.323 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.475494 | 0.323 |
| R-HSA-1640170 | Cell Cycle | 0.478357 | 0.320 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.480185 | 0.319 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.484834 | 0.314 |
| R-HSA-1280218 | Adaptive Immune System | 0.485973 | 0.313 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.489138 | 0.311 |
| R-HSA-913531 | Interferon Signaling | 0.489138 | 0.311 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.489441 | 0.310 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.489441 | 0.310 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.490290 | 0.310 |
| R-HSA-167172 | Transcription of the HIV genome | 0.494008 | 0.306 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.503020 | 0.298 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.503020 | 0.298 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.503020 | 0.298 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.503020 | 0.298 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.503020 | 0.298 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.503020 | 0.298 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.507466 | 0.295 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.507466 | 0.295 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.508151 | 0.294 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.511872 | 0.291 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.516096 | 0.287 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.516239 | 0.287 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.520568 | 0.284 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.520568 | 0.284 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.520568 | 0.284 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.520568 | 0.284 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.524858 | 0.280 |
| R-HSA-5689603 | UCH proteinases | 0.529110 | 0.276 |
| R-HSA-2559583 | Cellular Senescence | 0.532504 | 0.274 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.533324 | 0.273 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.537501 | 0.270 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.541640 | 0.266 |
| R-HSA-6806834 | Signaling by MET | 0.545743 | 0.263 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.545743 | 0.263 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.545743 | 0.263 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.549809 | 0.260 |
| R-HSA-977225 | Amyloid fiber formation | 0.549809 | 0.260 |
| R-HSA-199991 | Membrane Trafficking | 0.554869 | 0.256 |
| R-HSA-5617833 | Cilium Assembly | 0.559005 | 0.253 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.565716 | 0.247 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.569605 | 0.244 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.569605 | 0.244 |
| R-HSA-9663891 | Selective autophagy | 0.581065 | 0.236 |
| R-HSA-202424 | Downstream TCR signaling | 0.588536 | 0.230 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.588536 | 0.230 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.592222 | 0.228 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.599495 | 0.222 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.599495 | 0.222 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.615853 | 0.211 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.617120 | 0.210 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.617120 | 0.210 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.620551 | 0.207 |
| R-HSA-157579 | Telomere Maintenance | 0.620551 | 0.207 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.623952 | 0.205 |
| R-HSA-190236 | Signaling by FGFR | 0.623952 | 0.205 |
| R-HSA-68882 | Mitotic Anaphase | 0.625152 | 0.204 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.627323 | 0.203 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.627323 | 0.203 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.627450 | 0.202 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.633974 | 0.198 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.637256 | 0.196 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.637256 | 0.196 |
| R-HSA-1483255 | PI Metabolism | 0.637256 | 0.196 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.643731 | 0.191 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.643731 | 0.191 |
| R-HSA-9833110 | RSV-host interactions | 0.646926 | 0.189 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.650092 | 0.187 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.650709 | 0.187 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.653230 | 0.185 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.656339 | 0.183 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.656339 | 0.183 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.665504 | 0.177 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.674426 | 0.171 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.677347 | 0.169 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.677347 | 0.169 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.680242 | 0.167 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.683111 | 0.166 |
| R-HSA-5693538 | Homology Directed Repair | 0.694335 | 0.158 |
| R-HSA-68886 | M Phase | 0.701516 | 0.154 |
| R-HSA-73886 | Chromosome Maintenance | 0.702493 | 0.153 |
| R-HSA-5688426 | Deubiquitination | 0.706860 | 0.151 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.707811 | 0.150 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.710435 | 0.148 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.712491 | 0.147 |
| R-HSA-114608 | Platelet degranulation | 0.720697 | 0.142 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.721677 | 0.142 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.730615 | 0.136 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.737794 | 0.132 |
| R-HSA-163685 | Integration of energy metabolism | 0.747093 | 0.127 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.749366 | 0.125 |
| R-HSA-9658195 | Leishmania infection | 0.752730 | 0.123 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.752730 | 0.123 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.756110 | 0.121 |
| R-HSA-1632852 | Macroautophagy | 0.758257 | 0.120 |
| R-HSA-9679506 | SARS-CoV Infections | 0.760672 | 0.119 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.766835 | 0.115 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.773070 | 0.112 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.773503 | 0.112 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.774793 | 0.111 |
| R-HSA-1483257 | Phospholipid metabolism | 0.774793 | 0.111 |
| R-HSA-9758941 | Gastrulation | 0.777134 | 0.110 |
| R-HSA-9612973 | Autophagy | 0.790797 | 0.102 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.794546 | 0.100 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.801467 | 0.096 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.810606 | 0.091 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.813839 | 0.089 |
| R-HSA-418555 | G alpha (s) signalling events | 0.818983 | 0.087 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.818983 | 0.087 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.825419 | 0.083 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.825419 | 0.083 |
| R-HSA-449147 | Signaling by Interleukins | 0.833364 | 0.079 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.836802 | 0.077 |
| R-HSA-168256 | Immune System | 0.837739 | 0.077 |
| R-HSA-69275 | G2/M Transition | 0.841970 | 0.075 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.842407 | 0.074 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.844807 | 0.073 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.863300 | 0.064 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.864534 | 0.063 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.864534 | 0.063 |
| R-HSA-6805567 | Keratinization | 0.869359 | 0.061 |
| R-HSA-397014 | Muscle contraction | 0.876280 | 0.057 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.877398 | 0.057 |
| R-HSA-9824446 | Viral Infection Pathways | 0.894511 | 0.048 |
| R-HSA-168249 | Innate Immune System | 0.922736 | 0.035 |
| R-HSA-388396 | GPCR downstream signalling | 0.928741 | 0.032 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.932106 | 0.031 |
| R-HSA-109582 | Hemostasis | 0.932915 | 0.030 |
| R-HSA-112316 | Neuronal System | 0.935047 | 0.029 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.938583 | 0.028 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.942381 | 0.026 |
| R-HSA-5663205 | Infectious disease | 0.949193 | 0.023 |
| R-HSA-8957322 | Metabolism of steroids | 0.955378 | 0.020 |
| R-HSA-372790 | Signaling by GPCR | 0.957300 | 0.019 |
| R-HSA-1474244 | Extracellular matrix organization | 0.958143 | 0.019 |
| R-HSA-422475 | Axon guidance | 0.963869 | 0.016 |
| R-HSA-1643685 | Disease | 0.964797 | 0.016 |
| R-HSA-597592 | Post-translational protein modification | 0.969942 | 0.013 |
| R-HSA-9675108 | Nervous system development | 0.972906 | 0.012 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.975840 | 0.011 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.976711 | 0.010 |
| R-HSA-8978868 | Fatty acid metabolism | 0.979332 | 0.009 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.981993 | 0.008 |
| R-HSA-6798695 | Neutrophil degranulation | 0.986953 | 0.006 |
| R-HSA-211859 | Biological oxidations | 0.992908 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.994162 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 0.996155 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.999088 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.863 | 0.695 | 1 | 0.909 |
HIPK2 |
0.863 | 0.717 | 1 | 0.899 |
CDK18 |
0.863 | 0.733 | 1 | 0.936 |
CDK19 |
0.860 | 0.720 | 1 | 0.939 |
CDK7 |
0.857 | 0.718 | 1 | 0.935 |
CDK8 |
0.855 | 0.707 | 1 | 0.931 |
CDK17 |
0.855 | 0.720 | 1 | 0.937 |
CLK3 |
0.853 | 0.517 | 1 | 0.777 |
HIPK4 |
0.853 | 0.576 | 1 | 0.753 |
CDK1 |
0.852 | 0.693 | 1 | 0.934 |
DYRK2 |
0.849 | 0.671 | 1 | 0.869 |
JNK2 |
0.849 | 0.733 | 1 | 0.937 |
P38G |
0.849 | 0.721 | 1 | 0.935 |
CDK16 |
0.847 | 0.692 | 1 | 0.936 |
P38D |
0.847 | 0.730 | 1 | 0.939 |
CDK3 |
0.847 | 0.624 | 1 | 0.939 |
P38B |
0.846 | 0.727 | 1 | 0.901 |
CDK13 |
0.846 | 0.677 | 1 | 0.936 |
CDK5 |
0.845 | 0.664 | 1 | 0.922 |
ERK1 |
0.845 | 0.704 | 1 | 0.909 |
CDK12 |
0.843 | 0.677 | 1 | 0.938 |
CDK10 |
0.842 | 0.645 | 1 | 0.932 |
HIPK1 |
0.842 | 0.635 | 1 | 0.868 |
CDK14 |
0.842 | 0.686 | 1 | 0.929 |
DYRK4 |
0.841 | 0.660 | 1 | 0.918 |
JNK3 |
0.840 | 0.705 | 1 | 0.932 |
CDK9 |
0.837 | 0.657 | 1 | 0.931 |
P38A |
0.837 | 0.696 | 1 | 0.882 |
DYRK1B |
0.835 | 0.635 | 1 | 0.911 |
NLK |
0.834 | 0.604 | 1 | 0.793 |
DYRK1A |
0.831 | 0.560 | 1 | 0.878 |
SRPK1 |
0.831 | 0.335 | -3 | 0.782 |
HIPK3 |
0.831 | 0.610 | 1 | 0.840 |
ERK2 |
0.827 | 0.658 | 1 | 0.898 |
ICK |
0.826 | 0.418 | -3 | 0.857 |
MAK |
0.826 | 0.536 | -2 | 0.889 |
CLK2 |
0.825 | 0.395 | -3 | 0.785 |
MTOR |
0.824 | 0.255 | 1 | 0.617 |
ERK5 |
0.823 | 0.352 | 1 | 0.686 |
CDK6 |
0.822 | 0.629 | 1 | 0.931 |
DYRK3 |
0.821 | 0.494 | 1 | 0.833 |
CDK4 |
0.821 | 0.648 | 1 | 0.942 |
SRPK2 |
0.820 | 0.274 | -3 | 0.711 |
JNK1 |
0.820 | 0.628 | 1 | 0.940 |
CLK1 |
0.819 | 0.378 | -3 | 0.783 |
CLK4 |
0.819 | 0.359 | -3 | 0.795 |
CDK2 |
0.817 | 0.481 | 1 | 0.878 |
CDKL5 |
0.817 | 0.218 | -3 | 0.817 |
CDKL1 |
0.815 | 0.197 | -3 | 0.820 |
CDC7 |
0.815 | 0.037 | 1 | 0.507 |
COT |
0.814 | -0.032 | 2 | 0.725 |
PRKD1 |
0.814 | 0.133 | -3 | 0.865 |
NDR2 |
0.813 | 0.065 | -3 | 0.865 |
PIM3 |
0.811 | 0.059 | -3 | 0.862 |
PRKD2 |
0.810 | 0.119 | -3 | 0.822 |
MOS |
0.810 | 0.088 | 1 | 0.545 |
MOK |
0.810 | 0.473 | 1 | 0.766 |
PRP4 |
0.809 | 0.437 | -3 | 0.808 |
SRPK3 |
0.806 | 0.222 | -3 | 0.745 |
CHAK2 |
0.806 | 0.093 | -1 | 0.823 |
AURC |
0.806 | 0.100 | -2 | 0.683 |
RSK2 |
0.804 | 0.055 | -3 | 0.806 |
ATR |
0.803 | 0.015 | 1 | 0.522 |
PRPK |
0.803 | -0.059 | -1 | 0.831 |
NDR1 |
0.802 | 0.004 | -3 | 0.862 |
P90RSK |
0.802 | 0.056 | -3 | 0.807 |
TBK1 |
0.802 | -0.084 | 1 | 0.453 |
PIM1 |
0.800 | 0.075 | -3 | 0.816 |
SKMLCK |
0.799 | 0.024 | -2 | 0.868 |
RAF1 |
0.799 | -0.120 | 1 | 0.508 |
MST4 |
0.799 | -0.010 | 2 | 0.728 |
CAMK1B |
0.798 | -0.008 | -3 | 0.867 |
IKKB |
0.798 | -0.112 | -2 | 0.720 |
RSK3 |
0.798 | 0.033 | -3 | 0.804 |
IKKE |
0.798 | -0.104 | 1 | 0.456 |
PDHK4 |
0.797 | -0.154 | 1 | 0.555 |
MAPKAPK3 |
0.797 | 0.029 | -3 | 0.824 |
PKN3 |
0.796 | -0.025 | -3 | 0.856 |
PKCD |
0.796 | 0.017 | 2 | 0.640 |
MAPKAPK2 |
0.796 | 0.046 | -3 | 0.785 |
NIK |
0.795 | -0.015 | -3 | 0.880 |
NUAK2 |
0.795 | 0.006 | -3 | 0.868 |
PKACG |
0.795 | 0.023 | -2 | 0.745 |
BMPR2 |
0.794 | -0.131 | -2 | 0.848 |
CAMLCK |
0.794 | 0.025 | -2 | 0.855 |
DAPK2 |
0.794 | 0.021 | -3 | 0.873 |
PKACB |
0.794 | 0.087 | -2 | 0.684 |
MLK2 |
0.793 | -0.010 | 2 | 0.702 |
MPSK1 |
0.793 | 0.177 | 1 | 0.520 |
GCN2 |
0.793 | -0.198 | 2 | 0.661 |
PKN2 |
0.793 | -0.045 | -3 | 0.862 |
P70S6KB |
0.793 | 0.025 | -3 | 0.820 |
LATS2 |
0.792 | -0.014 | -5 | 0.686 |
IKKA |
0.792 | -0.040 | -2 | 0.707 |
WNK1 |
0.792 | -0.083 | -2 | 0.890 |
NEK6 |
0.791 | -0.059 | -2 | 0.810 |
GRK1 |
0.791 | 0.001 | -2 | 0.779 |
AMPKA1 |
0.791 | -0.012 | -3 | 0.879 |
TGFBR2 |
0.791 | -0.077 | -2 | 0.731 |
PRKD3 |
0.791 | 0.057 | -3 | 0.784 |
PAK6 |
0.791 | 0.051 | -2 | 0.741 |
RSK4 |
0.791 | 0.060 | -3 | 0.780 |
ERK7 |
0.790 | 0.196 | 2 | 0.426 |
MLK3 |
0.790 | -0.020 | 2 | 0.600 |
CAMK2D |
0.790 | -0.051 | -3 | 0.864 |
AMPKA2 |
0.790 | 0.017 | -3 | 0.855 |
AKT2 |
0.790 | 0.079 | -3 | 0.732 |
PDHK1 |
0.790 | -0.167 | 1 | 0.534 |
ULK2 |
0.789 | -0.204 | 2 | 0.648 |
PRKX |
0.789 | 0.096 | -3 | 0.739 |
GRK7 |
0.789 | 0.063 | 1 | 0.494 |
MNK2 |
0.789 | 0.011 | -2 | 0.801 |
GSK3A |
0.788 | 0.203 | 4 | 0.464 |
RIPK3 |
0.788 | -0.133 | 3 | 0.701 |
PKCA |
0.788 | 0.012 | 2 | 0.588 |
PAK1 |
0.788 | 0.001 | -2 | 0.816 |
GRK5 |
0.787 | -0.128 | -3 | 0.826 |
DSTYK |
0.787 | -0.185 | 2 | 0.729 |
MARK4 |
0.787 | -0.070 | 4 | 0.737 |
PHKG1 |
0.787 | -0.023 | -3 | 0.856 |
LATS1 |
0.787 | 0.047 | -3 | 0.871 |
PKCB |
0.786 | -0.019 | 2 | 0.595 |
MLK1 |
0.786 | -0.159 | 2 | 0.661 |
MASTL |
0.785 | -0.152 | -2 | 0.804 |
CAMK2G |
0.785 | -0.155 | 2 | 0.649 |
PAK3 |
0.785 | -0.024 | -2 | 0.807 |
MNK1 |
0.785 | 0.016 | -2 | 0.807 |
AURB |
0.785 | 0.036 | -2 | 0.675 |
PKCZ |
0.784 | -0.019 | 2 | 0.645 |
PKCG |
0.784 | -0.026 | 2 | 0.590 |
PKG2 |
0.784 | 0.034 | -2 | 0.689 |
DLK |
0.783 | -0.159 | 1 | 0.500 |
IRE1 |
0.782 | -0.108 | 1 | 0.454 |
MSK2 |
0.782 | -0.011 | -3 | 0.778 |
CAMK2A |
0.782 | -0.005 | 2 | 0.647 |
BCKDK |
0.782 | -0.156 | -1 | 0.790 |
NEK7 |
0.782 | -0.210 | -3 | 0.805 |
MSK1 |
0.782 | 0.021 | -3 | 0.788 |
TSSK1 |
0.782 | -0.042 | -3 | 0.895 |
DNAPK |
0.781 | -0.011 | 1 | 0.468 |
PIM2 |
0.781 | 0.062 | -3 | 0.782 |
QSK |
0.781 | -0.016 | 4 | 0.721 |
NIM1 |
0.780 | -0.088 | 3 | 0.723 |
SGK3 |
0.780 | 0.025 | -3 | 0.815 |
WNK3 |
0.779 | -0.248 | 1 | 0.486 |
VRK2 |
0.779 | 0.014 | 1 | 0.572 |
NEK9 |
0.779 | -0.190 | 2 | 0.696 |
CAMK4 |
0.778 | -0.089 | -3 | 0.847 |
CAMK2B |
0.778 | -0.055 | 2 | 0.629 |
CHAK1 |
0.778 | -0.087 | 2 | 0.712 |
BMPR1B |
0.778 | -0.033 | 1 | 0.462 |
ULK1 |
0.778 | -0.210 | -3 | 0.782 |
BUB1 |
0.778 | 0.175 | -5 | 0.785 |
SMG1 |
0.778 | -0.046 | 1 | 0.489 |
NUAK1 |
0.777 | -0.036 | -3 | 0.820 |
RIPK1 |
0.777 | -0.202 | 1 | 0.454 |
AKT1 |
0.777 | 0.054 | -3 | 0.758 |
YSK4 |
0.777 | -0.126 | 1 | 0.476 |
PINK1 |
0.776 | 0.117 | 1 | 0.656 |
PAK2 |
0.776 | -0.038 | -2 | 0.800 |
PKR |
0.776 | -0.099 | 1 | 0.500 |
TSSK2 |
0.776 | -0.103 | -5 | 0.802 |
MELK |
0.776 | -0.065 | -3 | 0.839 |
IRE2 |
0.775 | -0.098 | 2 | 0.592 |
TAO3 |
0.775 | 0.027 | 1 | 0.514 |
MST3 |
0.775 | -0.016 | 2 | 0.712 |
ANKRD3 |
0.775 | -0.202 | 1 | 0.504 |
ALK4 |
0.775 | -0.072 | -2 | 0.759 |
SIK |
0.775 | -0.026 | -3 | 0.792 |
MLK4 |
0.775 | -0.100 | 2 | 0.582 |
DCAMKL1 |
0.775 | -0.014 | -3 | 0.831 |
PKACA |
0.774 | 0.053 | -2 | 0.636 |
GRK6 |
0.774 | -0.164 | 1 | 0.494 |
HUNK |
0.774 | -0.248 | 2 | 0.675 |
AURA |
0.774 | 0.008 | -2 | 0.647 |
TLK2 |
0.774 | -0.065 | 1 | 0.477 |
GSK3B |
0.774 | 0.068 | 4 | 0.461 |
PKCH |
0.774 | -0.068 | 2 | 0.570 |
MEK1 |
0.774 | -0.145 | 2 | 0.714 |
QIK |
0.773 | -0.115 | -3 | 0.851 |
CHK1 |
0.773 | -0.012 | -3 | 0.865 |
PAK5 |
0.772 | 0.017 | -2 | 0.684 |
LKB1 |
0.772 | 0.098 | -3 | 0.840 |
TTBK2 |
0.772 | -0.211 | 2 | 0.575 |
GRK4 |
0.771 | -0.178 | -2 | 0.788 |
ATM |
0.771 | -0.096 | 1 | 0.471 |
BRSK2 |
0.771 | -0.085 | -3 | 0.846 |
NEK2 |
0.771 | -0.139 | 2 | 0.685 |
PASK |
0.771 | 0.017 | -3 | 0.874 |
TGFBR1 |
0.770 | -0.083 | -2 | 0.724 |
AKT3 |
0.770 | 0.073 | -3 | 0.685 |
MYLK4 |
0.770 | -0.028 | -2 | 0.780 |
PKCT |
0.770 | -0.040 | 2 | 0.585 |
PAK4 |
0.769 | 0.021 | -2 | 0.689 |
ACVR2B |
0.768 | -0.079 | -2 | 0.728 |
BRSK1 |
0.768 | -0.075 | -3 | 0.828 |
GCK |
0.767 | 0.026 | 1 | 0.508 |
MARK3 |
0.767 | -0.070 | 4 | 0.665 |
PKCI |
0.767 | -0.034 | 2 | 0.603 |
MEK5 |
0.767 | -0.154 | 2 | 0.695 |
P70S6K |
0.767 | -0.005 | -3 | 0.745 |
ACVR2A |
0.766 | -0.096 | -2 | 0.718 |
MAPKAPK5 |
0.766 | -0.071 | -3 | 0.760 |
DRAK1 |
0.766 | -0.144 | 1 | 0.443 |
ZAK |
0.765 | -0.150 | 1 | 0.464 |
PKCE |
0.765 | 0.002 | 2 | 0.579 |
SBK |
0.765 | 0.131 | -3 | 0.630 |
FAM20C |
0.765 | -0.080 | 2 | 0.461 |
IRAK4 |
0.765 | -0.132 | 1 | 0.441 |
MEKK2 |
0.764 | -0.117 | 2 | 0.666 |
PLK4 |
0.764 | -0.141 | 2 | 0.505 |
PBK |
0.763 | 0.054 | 1 | 0.495 |
NEK5 |
0.763 | -0.122 | 1 | 0.478 |
MEKK1 |
0.763 | -0.166 | 1 | 0.488 |
DCAMKL2 |
0.763 | -0.055 | -3 | 0.841 |
MARK2 |
0.763 | -0.099 | 4 | 0.632 |
SGK1 |
0.762 | 0.068 | -3 | 0.666 |
PHKG2 |
0.762 | -0.088 | -3 | 0.829 |
PERK |
0.762 | -0.156 | -2 | 0.790 |
PLK1 |
0.762 | -0.193 | -2 | 0.749 |
HPK1 |
0.762 | -0.004 | 1 | 0.499 |
CAMK1G |
0.762 | -0.072 | -3 | 0.787 |
TNIK |
0.762 | 0.022 | 3 | 0.845 |
GAK |
0.761 | -0.025 | 1 | 0.545 |
KHS1 |
0.761 | 0.039 | 1 | 0.487 |
CK1E |
0.761 | -0.032 | -3 | 0.526 |
HGK |
0.761 | -0.013 | 3 | 0.842 |
WNK4 |
0.761 | -0.147 | -2 | 0.887 |
TAO2 |
0.761 | -0.052 | 2 | 0.702 |
PDK1 |
0.761 | -0.039 | 1 | 0.495 |
MAP3K15 |
0.760 | -0.035 | 1 | 0.469 |
NEK11 |
0.760 | -0.112 | 1 | 0.499 |
KHS2 |
0.760 | 0.041 | 1 | 0.506 |
SMMLCK |
0.760 | -0.035 | -3 | 0.836 |
BRAF |
0.760 | -0.143 | -4 | 0.830 |
ALK2 |
0.760 | -0.122 | -2 | 0.741 |
MEKK6 |
0.759 | -0.069 | 1 | 0.480 |
LOK |
0.759 | -0.011 | -2 | 0.769 |
MRCKA |
0.759 | 0.035 | -3 | 0.792 |
DAPK3 |
0.759 | -0.001 | -3 | 0.830 |
ROCK2 |
0.758 | 0.046 | -3 | 0.830 |
MEKK3 |
0.758 | -0.209 | 1 | 0.483 |
SLK |
0.758 | -0.006 | -2 | 0.707 |
SNRK |
0.757 | -0.200 | 2 | 0.549 |
PKN1 |
0.757 | -0.028 | -3 | 0.770 |
GRK2 |
0.757 | -0.112 | -2 | 0.668 |
MRCKB |
0.757 | 0.032 | -3 | 0.777 |
CK1D |
0.757 | -0.001 | -3 | 0.475 |
MINK |
0.757 | -0.055 | 1 | 0.477 |
MARK1 |
0.756 | -0.123 | 4 | 0.686 |
SSTK |
0.756 | -0.097 | 4 | 0.716 |
CAMK1D |
0.756 | -0.019 | -3 | 0.736 |
BMPR1A |
0.756 | -0.078 | 1 | 0.451 |
HRI |
0.755 | -0.212 | -2 | 0.803 |
CAMKK2 |
0.754 | -0.078 | -2 | 0.771 |
CHK2 |
0.754 | 0.008 | -3 | 0.694 |
NEK4 |
0.753 | -0.113 | 1 | 0.462 |
LRRK2 |
0.753 | -0.045 | 2 | 0.699 |
CRIK |
0.752 | 0.073 | -3 | 0.759 |
NEK8 |
0.752 | -0.175 | 2 | 0.670 |
PLK3 |
0.752 | -0.189 | 2 | 0.621 |
CAMKK1 |
0.752 | -0.165 | -2 | 0.768 |
CK1G1 |
0.751 | -0.070 | -3 | 0.499 |
DAPK1 |
0.750 | -0.019 | -3 | 0.811 |
MST2 |
0.750 | -0.123 | 1 | 0.492 |
TLK1 |
0.750 | -0.182 | -2 | 0.757 |
DMPK1 |
0.750 | 0.058 | -3 | 0.799 |
NEK1 |
0.749 | -0.097 | 1 | 0.453 |
CK1A2 |
0.748 | -0.036 | -3 | 0.477 |
TAK1 |
0.748 | -0.150 | 1 | 0.494 |
TTBK1 |
0.747 | -0.195 | 2 | 0.503 |
CAMK1A |
0.746 | -0.006 | -3 | 0.708 |
HASPIN |
0.746 | 0.004 | -1 | 0.687 |
YSK1 |
0.745 | -0.096 | 2 | 0.676 |
EEF2K |
0.745 | -0.114 | 3 | 0.781 |
PDHK3_TYR |
0.744 | 0.191 | 4 | 0.818 |
MST1 |
0.743 | -0.121 | 1 | 0.478 |
IRAK1 |
0.743 | -0.270 | -1 | 0.765 |
PKG1 |
0.743 | -0.011 | -2 | 0.609 |
LIMK2_TYR |
0.742 | 0.215 | -3 | 0.892 |
VRK1 |
0.742 | -0.190 | 2 | 0.691 |
ROCK1 |
0.741 | 0.011 | -3 | 0.795 |
GRK3 |
0.740 | -0.118 | -2 | 0.618 |
CK2A2 |
0.739 | -0.090 | 1 | 0.421 |
BIKE |
0.738 | -0.004 | 1 | 0.484 |
TESK1_TYR |
0.738 | 0.110 | 3 | 0.849 |
STK33 |
0.738 | -0.164 | 2 | 0.506 |
MEK2 |
0.738 | -0.204 | 2 | 0.692 |
PDHK4_TYR |
0.737 | 0.107 | 2 | 0.756 |
MYO3B |
0.737 | -0.035 | 2 | 0.701 |
OSR1 |
0.737 | -0.062 | 2 | 0.685 |
TAO1 |
0.736 | -0.063 | 1 | 0.455 |
NEK3 |
0.735 | -0.120 | 1 | 0.454 |
ASK1 |
0.734 | -0.098 | 1 | 0.467 |
PKMYT1_TYR |
0.734 | 0.123 | 3 | 0.816 |
MAP2K4_TYR |
0.733 | 0.085 | -1 | 0.841 |
AAK1 |
0.733 | 0.042 | 1 | 0.442 |
CK2A1 |
0.732 | -0.091 | 1 | 0.408 |
MYO3A |
0.732 | -0.069 | 1 | 0.477 |
RIPK2 |
0.731 | -0.267 | 1 | 0.438 |
MAP2K6_TYR |
0.730 | 0.025 | -1 | 0.846 |
PLK2 |
0.730 | -0.114 | -3 | 0.755 |
MAP2K7_TYR |
0.729 | -0.076 | 2 | 0.721 |
TTK |
0.729 | -0.096 | -2 | 0.767 |
YANK3 |
0.727 | -0.072 | 2 | 0.330 |
BMPR2_TYR |
0.726 | -0.011 | -1 | 0.823 |
PDHK1_TYR |
0.725 | -0.035 | -1 | 0.831 |
PINK1_TYR |
0.724 | -0.149 | 1 | 0.533 |
NEK10_TYR |
0.723 | 0.003 | 1 | 0.455 |
LIMK1_TYR |
0.722 | -0.036 | 2 | 0.715 |
RET |
0.721 | -0.086 | 1 | 0.491 |
CK1A |
0.721 | -0.040 | -3 | 0.379 |
MST1R |
0.719 | -0.079 | 3 | 0.788 |
ALPHAK3 |
0.718 | -0.105 | -1 | 0.705 |
JAK2 |
0.717 | -0.083 | 1 | 0.492 |
CSF1R |
0.717 | -0.072 | 3 | 0.762 |
ROS1 |
0.715 | -0.114 | 3 | 0.746 |
TYK2 |
0.715 | -0.177 | 1 | 0.481 |
TYRO3 |
0.715 | -0.148 | 3 | 0.774 |
TNK1 |
0.714 | -0.028 | 3 | 0.754 |
TNK2 |
0.714 | -0.050 | 3 | 0.732 |
JAK1 |
0.713 | -0.025 | 1 | 0.452 |
TXK |
0.713 | -0.045 | 1 | 0.466 |
STLK3 |
0.713 | -0.185 | 1 | 0.448 |
EPHB4 |
0.712 | -0.109 | -1 | 0.754 |
ABL2 |
0.712 | -0.058 | -1 | 0.732 |
TNNI3K_TYR |
0.712 | -0.031 | 1 | 0.475 |
EPHA6 |
0.711 | -0.128 | -1 | 0.767 |
JAK3 |
0.711 | -0.122 | 1 | 0.477 |
LCK |
0.710 | -0.049 | -1 | 0.778 |
DDR1 |
0.709 | -0.178 | 4 | 0.742 |
ABL1 |
0.709 | -0.078 | -1 | 0.729 |
FGR |
0.707 | -0.148 | 1 | 0.478 |
YES1 |
0.707 | -0.127 | -1 | 0.798 |
ITK |
0.706 | -0.126 | -1 | 0.768 |
FGFR2 |
0.704 | -0.114 | 3 | 0.751 |
TEK |
0.704 | -0.079 | 3 | 0.704 |
HCK |
0.704 | -0.148 | -1 | 0.779 |
KDR |
0.703 | -0.110 | 3 | 0.712 |
KIT |
0.703 | -0.136 | 3 | 0.760 |
BLK |
0.703 | -0.071 | -1 | 0.764 |
FER |
0.702 | -0.206 | 1 | 0.494 |
FGFR1 |
0.702 | -0.099 | 3 | 0.725 |
INSRR |
0.701 | -0.178 | 3 | 0.709 |
MET |
0.701 | -0.099 | 3 | 0.767 |
EPHA4 |
0.701 | -0.123 | 2 | 0.631 |
PDGFRB |
0.701 | -0.207 | 3 | 0.769 |
SRMS |
0.700 | -0.186 | 1 | 0.469 |
AXL |
0.699 | -0.169 | 3 | 0.748 |
EPHB1 |
0.699 | -0.180 | 1 | 0.467 |
PDGFRA |
0.699 | -0.187 | 3 | 0.766 |
FLT3 |
0.698 | -0.207 | 3 | 0.762 |
WEE1_TYR |
0.698 | -0.128 | -1 | 0.727 |
EPHB3 |
0.696 | -0.175 | -1 | 0.737 |
MERTK |
0.696 | -0.166 | 3 | 0.743 |
BMX |
0.695 | -0.125 | -1 | 0.661 |
DDR2 |
0.694 | -0.069 | 3 | 0.693 |
FYN |
0.694 | -0.098 | -1 | 0.759 |
EPHB2 |
0.693 | -0.182 | -1 | 0.725 |
PTK6 |
0.692 | -0.185 | -1 | 0.707 |
BTK |
0.692 | -0.238 | -1 | 0.742 |
YANK2 |
0.692 | -0.098 | 2 | 0.334 |
FGFR3 |
0.692 | -0.137 | 3 | 0.720 |
FLT1 |
0.691 | -0.160 | -1 | 0.748 |
ALK |
0.691 | -0.181 | 3 | 0.679 |
TEC |
0.691 | -0.180 | -1 | 0.681 |
EPHA1 |
0.689 | -0.174 | 3 | 0.749 |
CK1G3 |
0.689 | -0.072 | -3 | 0.332 |
ERBB2 |
0.688 | -0.198 | 1 | 0.466 |
PTK2B |
0.688 | -0.120 | -1 | 0.721 |
EPHA7 |
0.688 | -0.162 | 2 | 0.626 |
FRK |
0.686 | -0.184 | -1 | 0.757 |
LYN |
0.686 | -0.162 | 3 | 0.673 |
EPHA3 |
0.686 | -0.187 | 2 | 0.605 |
INSR |
0.685 | -0.207 | 3 | 0.699 |
NTRK1 |
0.685 | -0.255 | -1 | 0.755 |
LTK |
0.685 | -0.213 | 3 | 0.696 |
FLT4 |
0.684 | -0.217 | 3 | 0.697 |
NTRK3 |
0.684 | -0.167 | -1 | 0.704 |
NTRK2 |
0.683 | -0.250 | 3 | 0.708 |
SRC |
0.683 | -0.149 | -1 | 0.746 |
PTK2 |
0.681 | -0.079 | -1 | 0.721 |
MATK |
0.680 | -0.145 | -1 | 0.645 |
EPHA8 |
0.680 | -0.151 | -1 | 0.711 |
EGFR |
0.679 | -0.147 | 1 | 0.403 |
CSK |
0.679 | -0.178 | 2 | 0.631 |
EPHA5 |
0.678 | -0.189 | 2 | 0.608 |
FGFR4 |
0.676 | -0.148 | -1 | 0.680 |
SYK |
0.676 | -0.099 | -1 | 0.685 |
MUSK |
0.674 | -0.170 | 1 | 0.395 |
ZAP70 |
0.672 | -0.034 | -1 | 0.632 |
EPHA2 |
0.671 | -0.160 | -1 | 0.673 |
ERBB4 |
0.668 | -0.125 | 1 | 0.412 |
CK1G2 |
0.667 | -0.081 | -3 | 0.423 |
IGF1R |
0.664 | -0.212 | 3 | 0.633 |
FES |
0.653 | -0.202 | -1 | 0.643 |